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TTLAHTAALVTGASSGIGAATATALAAEGAAVALLARRADRLAELQAEIECSGGTALVVPADVTDAERVA AAVQRTVAEFGRLDILVNNAGLMQSGPATEASLRDWDRMVAVNVQGVLYATRAALPHLVDAAADSPRGVA DLVTISSTAGWVARPNTAVYSLTKFGVNAFSEGIRQEVLGKRVRVGVVGPGTVDTEIFGHLSEPSREAFE RQTAGMVMLRPQDIADAVLFMVTRDRRVAVNHMLVRAAEQTW*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_2980 | - | - | 100% (253) | clavaldehyde dehydrogenase |
| M. avium 104 | MAV_4667 | - | 2e-32 | 38.93% (244) | oxidoreductase |
| M. avium 104 | MAV_2700 | - | 4e-31 | 38.30% (235) | short chain dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0494c | - | 3e-33 | 38.58% (254) | putative short-chain type oxidoreductase |
| M. gilvum PYR-GCK | Mflv_0088 | - | 9e-31 | 37.90% (248) | short-chain dehydrogenase/reductase SDR |
| M. tuberculosis H37Rv | Rv0484c | - | 3e-33 | 38.58% (254) | short-chain type oxidoreductase |
| M. leprae Br4923 | MLBr_01094 | - | 5e-24 | 33.16% (196) | short chain alcohol dehydrogenase |
| M. abscessus ATCC 19977 | MAB_4060 | - | 2e-33 | 39.34% (244) | putative short chain dehydrogenase/reductase |
| M. marinum M | MMAR_0810 | - | 4e-31 | 37.05% (251) | short-chain type oxidoreductase |
| M. smegmatis MC2 155 | MSMEG_5569 | - | 7e-67 | 55.02% (249) | clavaldehyde dehydrogenase |
| M. thermoresistible (build 8) | TH_4266 | - | 2e-30 | 34.60% (237) | PUTATIVE short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_4554 | - | 1e-31 | 37.05% (251) | short-chain type oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_3063 | - | 2e-37 | 37.34% (241) | short-chain dehydrogenase/reductase SDR |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_2980|M.avium_104 --MT-TLAHTAALVTGASSGIGAATATALAAEGAAVALLARRADRLAELQ
MSMEG_5569|M.smegmatis_MC2_155 --MSPKLTGTVALVTGASSGIGAATARHLAEHGATVALVARRKDRLVTLV
Mvan_3063|M.vanbaalenii_PYR-1 -MVNDPIDGMVVAITGASSGIGEATARLLGTRGARLVLGARRADRLHTLG
Mb0494c|M.bovis_AF2122/97 -MTTIGTRKRVAVVTGASSGIGEATARTLAAQGFHVVAVARRADRITALA
Rv0484c|M.tuberculosis_H37Rv -MTTIGTRKRVAVVTGASSGIGEATARTLAAQGFHVVAVARRADRITALA
MMAR_0810|M.marinum_M -MTTTDAGNRVAVVTGASSGIGEATARTLAAQGFHVVAVARRADRITALT
MUL_4554|M.ulcerans_Agy99 -MTTTDAGNRVAVVTGASSGIGEATARTLAAQGFHVVAVARRADRITALT
MAB_4060|M.abscessus_ATCC_1997 -MTNPTFDGRVAVVTGASSGIGAATAKSLAALGFHVVVAARREDRVKSLA
Mflv_0088|M.gilvum_PYR-GCK -MTTPSDARRVAVVTGASAGIGEAIARTLAAQGFHVICVARREGPIKALA
MLBr_01094|M.leprae_Br4923 ---MEGFAGKVAVVTGAGSGIGQALAIELARSGAKLAISDVDGEGLAQTE
TH_4266|M.thermoresistible__bu VDDRFSMAGRVAVITGGGTGIGRASALVLAEYGADIVLAGRRPEPLKKTA
.. :**..:*** * * *. * : :
MAV_2980|M.avium_104 AEIECSGGTALVVPADVTDAERVAAAVQRTVAEFGRLDILVNNAG-LMQS
MSMEG_5569|M.smegmatis_MC2_155 ADIERDGGAATAVEADVSDRAQADAAVAETVQRFGRLDIVVNNAG-LMLL
Mvan_3063|M.vanbaalenii_PYR-1 GELRAAGAEVATVTTDVTAAGDLERLVGTAVADFGRLDVLVSNAG-ISAI
Mb0494c|M.bovis_AF2122/97 NQIGG-----TAIVADVTDDAAVEALARA----LSRVDVLVNNAGGAKGL
Rv0484c|M.tuberculosis_H37Rv NQIGG-----TAIVADVTDDAAVEALARA----LSRVDVLVNNAGGAKGL
MMAR_0810|M.marinum_M DQIGG-----TPIVADVTDGAAVAALADG----LSRVDVLVNNAGGAKGL
MUL_4554|M.ulcerans_Agy99 DQIGG-----TPIVADVTDGAAVAALADG----LSRVDVLVNNAGGAKEL
MAB_4060|M.abscessus_ATCC_1997 GEIGG-----TAFVLDVTDADSVAALTQS----LDRVDVLVNNAGGAWGL
Mflv_0088|M.gilvum_PYR-GCK AEIDG-----TAIVADVTDPTAVAALAGR----LDRVDVLVNNAGGARGL
MLBr_01094|M.leprae_Br4923 GQLKAIGASARTDRLDVTEREAFLTYADVVHENFGKVNQIYNNAG-IAFT
TH_4266|M.thermoresistible__bu AEIEALGRRALAVPTDVTAPDECRALVDATVGEFGRLDVLVNNAG-GGAT
:: **: . :.::: : .***
MAV_2980|M.avium_104 GPATEASLRDWDRMVAVNVQGVLYATRAALPHLVDAAADSPRGVADLVTI
MSMEG_5569|M.smegmatis_MC2_155 GPVAGADAQDWDRMIAVNVSGLLNTTHAALPHLLAAAEDGPREVADIVNV
Mvan_3063|M.vanbaalenii_PYR-1 GPLADADVTGWDAMIDVNLRGVLHGIAAAMPVFRQQGHG------HFVTT
Mb0494c|M.bovis_AF2122/97 QFVADADLEHWRWMWDTNVLGTLRVTRALLPKLIDSGDG------LIVTV
Rv0484c|M.tuberculosis_H37Rv QFVADADLEHWRWMWDTNVLGTLRVTRALLPKLIDSGDG------LIVTV
MMAR_0810|M.marinum_M EPVADADLEHWRWMWETNVLGTLRVTRALLPKLIASGDG------LIVTV
MUL_4554|M.ulcerans_Agy99 EPVADADLEHWRWMWETNVLGTLRVTRALLPKLIASGDG------LIVTV
MAB_4060|M.abscessus_ATCC_1997 EPVLEADLEHWRWMWETNVVGTLQVTRALLPKLIDSGDG------LIVTV
Mflv_0088|M.gilvum_PYR-GCK ESISDADVENWRWMWEANVMGTLHVTRALLPKLIDSGDG------LIVTI
MLBr_01094|M.leprae_Br4923 GDVEVSHFKDIERVMDVDYWGVVNGTKAFLPYLISSGDG------HVINI
TH_4266|M.thermoresistible__bu KPLMKWTDDEWHEVLNLNLSSAWYLSRAAAKPMIDQGRG------AIVNI
: : . * : . . .:.
MAV_2980|M.avium_104 SSTAGWVARPNTAVYSLTKFGVNAFSEGIRQEV--LGKRVRVGVVGPGTV
MSMEG_5569|M.smegmatis_MC2_155 SSVAGRNASEGYGVYSLTKFGVNGFTESLRQEV--TRRHVRVGVIEPGGV
Mvan_3063|M.vanbaalenii_PYR-1 VSTAGLKIVPTMGVYAATKNAVRTMMEALRQES--TDGVIRTTSISPGYV
Mb0494c|M.bovis_AF2122/97 TSIAALEVYDGGAGYTAAKHAQGALHRTLRGEL--LGKPVRLTEIAPGAV
Rv0484c|M.tuberculosis_H37Rv TSIAAIEVYDGGAGYTAAKHAQGALHRTLRGEL--LGKPVRLTEIAPGAV
MMAR_0810|M.marinum_M TSIAALEIYDGGAGYTAAKHAQGALHRTLRGEL--LGLPVRLTEIAPGAV
MUL_4554|M.ulcerans_Agy99 TSIAALEIYDGGAGYTAAKHAQGALHRTLRGEL--LGLPVRLTEIAPGAV
MAB_4060|M.abscessus_ATCC_1997 TSIAALDVYDGGSGYTSAKHAQAALHRTLRGEL--LGKPVRLTEVAPGAV
Mflv_0088|M.gilvum_PYR-GCK TSIAAVEIYDNGGGYTSAKHAQGVLHRTLRSEL--LGKPVRLTEVAPGMV
MLBr_01094|M.leprae_Br4923 SSVFGLFSVPGQAAYNSAKFAVRGFTEALREEMALAGRPVNVTTVYPGGI
TH_4266|M.thermoresistible__bu SSGAGLLAMPQAPVYAAAKAGLNNLTGSMAAAW--TRKGVRVNCIACGAI
* . * :* . : : :. : * :
MAV_2980|M.avium_104 DTEIFGHLSEPSRE----AFERQTAGMVMLRPQDIADAVLFMVTRD----
MSMEG_5569|M.smegmatis_MC2_155 NTELGSHNSSAIQAR---IIEPFNASVEALAPEDVAESIGYMVTRP----
Mvan_3063|M.vanbaalenii_PYR-1 NTELDRSITDVALR----NAVRADMDAFGLAPEAVARAIVFAIEQP----
Mb0494c|M.bovis_AF2122/97 ETEFSLVRFDGDQQ----RADAVYAGMTPLVAADVAEVIGFVATRP----
Rv0484c|M.tuberculosis_H37Rv ETEFSLVRFDGDQQ----RADAVYAGMTPLVAADVAEVIGFVATRP----
MMAR_0810|M.marinum_M ETEFSLVRFDGDEQ----RADAVYSGMTPLVAADIAEVIGFVASRP----
MUL_4554|M.ulcerans_Agy99 ETEFSLVRFDGDEQ----RADAVYSGMTPLVAADIAEVIGFVASRP----
MAB_4060|M.abscessus_ATCC_1997 ETEFSVVRFDGDQD----RADAVYRGITPLVAEDVAEIIAFVASRP----
Mflv_0088|M.gilvum_PYR-GCK KTDFSLNRFDGDAE----RAEKVYEGVTPLVAEDIAEVVGFVASRP----
MLBr_01094|M.leprae_Br4923 KTAIARNATAAEGLDVSKIASRFDTWVAHTSPQHAARIILKAVRKKKARV
TH_4266|M.thermoresistible__bu RTPGLEADAKRQGFDID-MIGQTNGSGRIAEPDEIGYGVLFFASDAS---
* . . :
MAV_2980|M.avium_104 ---RRVAVNHMLVRAAEQTW-----------------
MSMEG_5569|M.smegmatis_MC2_155 ---RHAAIGELWIMPTEQLV-----------------
Mvan_3063|M.vanbaalenii_PYR-1 ---PEVEIGDLTIRPAVQG------------------
Mb0494c|M.bovis_AF2122/97 ---SHVNLDQIVIRPRDQAS--ASRRATHPVR-----
Rv0484c|M.tuberculosis_H37Rv ---SHVNLDQIVIRPRDQAS--ASRRATHPVR-----
MMAR_0810|M.marinum_M ---PHVNLDQIIIRPRDQAS--ATRRANHQV------
MUL_4554|M.ulcerans_Agy99 ---PHVNLDQIIIRPRDQAS--ATRRANHQV------
MAB_4060|M.abscessus_ATCC_1997 ---PHVNLDQIVVKPRDQAS--STRRATRQ-------
Mflv_0088|M.gilvum_PYR-GCK ---SHVDLDLIVVRPRDQVSGASGSRFHRQS------
MLBr_01094|M.leprae_Br4923 LVGPDAKVANVVVRFSGGAGYQRLFAQVASRLILNQR
TH_4266|M.thermoresistible__bu ---SYCSGQTLYMHGGPGPAGV---------------
: :