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SAHEHVHEDSVAGQVVTITGASSGIGEATARLLAARGASVVLGARRTDRLDRIVEEIRSTGGAAVAVAVD VTRRADVDNLVATAVREFGRLDVLVNNAGIATLGPLADGDTDTWSAVIDVNVRGVLHGIAAATPVFTCQG RGHVITVVSTAGLKIVPEMGVYAGTKNAVRTIMEALRQESTDGVIRTTSISPGYVRTELGGPPGGPAGNA ARATMDRIGLPPDAVARAIAFAIEQPHDVEIGDLTIRPTVQG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_3581 | - | - | 100% (253) | FabG protein |
| M. smegmatis MC2 155 | MSMEG_0258 | - | 1e-46 | 44.96% (238) | oxidoreductase, short chain dehydrogenase/reductase family |
| M. smegmatis MC2 155 | MSMEG_5569 | - | 1e-42 | 42.19% (256) | clavaldehyde dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0788c | - | 9e-31 | 33.47% (248) | short chain dehydrogenase |
| M. gilvum PYR-GCK | Mflv_3370 | - | 3e-32 | 38.62% (189) | short-chain dehydrogenase/reductase SDR |
| M. tuberculosis H37Rv | Rv0765c | - | 9e-31 | 33.47% (248) | short chain dehydrogenase |
| M. leprae Br4923 | MLBr_01094 | - | 7e-23 | 33.16% (193) | short chain alcohol dehydrogenase |
| M. abscessus ATCC 19977 | MAB_1215c | - | 4e-30 | 34.71% (242) | short chain dehydrogenase |
| M. marinum M | MMAR_0387 | fabG3 | 2e-31 | 42.86% (189) | 20-beta-hydroxysteroid dehydrogenase FabG3 |
| M. avium 104 | MAV_2980 | - | 1e-38 | 38.55% (249) | clavaldehyde dehydrogenase |
| M. thermoresistible (build 8) | TH_4266 | - | 1e-29 | 38.83% (188) | PUTATIVE short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_1037 | fabG3 | 3e-31 | 42.33% (189) | 20-beta-hydroxysteroid dehydrogenase FabG3 |
| M. vanbaalenii PYR-1 | Mvan_3063 | - | 3e-88 | 69.39% (245) | short-chain dehydrogenase/reductase SDR |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_0387|M.marinum_M --------MGRVDGKVALISGGARGMGASHARLLVQEGAKVVIGDILDEE
MUL_1037|M.ulcerans_Agy99 --------MGRVDGKVALISGGARGMGASHARLLVQEGAKVVIGDILDEE
TH_4266|M.thermoresistible__bu -----VDDRFSMAGRVAVITGGGTGIGRASALVLAEYGADIVLAGRRPEP
MSMEG_3581|M.smegmatis_MC2_155 MSAHEHVHEDSVAGQVVTITGASSGIGEATARLLAARGASVVLGARRTDR
Mvan_3063|M.vanbaalenii_PYR-1 ------MVNDPIDGMVVAITGASSGIGEATARLLGTRGARLVLGARRADR
Mb0788c|M.bovis_AF2122/97 ----MPRFEPHPARRTTVVAGASSGIGAATATELAGRGFPVALGARRMDK
Rv0765c|M.tuberculosis_H37Rv ----MPRFEPHPARRTTVVAGASSGIGAATATELAGRGFPVALGARRMDK
MAB_1215c|M.abscessus_ATCC_199 ----MPRFEPHPARRPSIIAGASSGIGAATAIELAGRGFPVALGARRVDK
MAV_2980|M.avium_104 --------MTTLAHTAALVTGASSGIGAATATALAAEGAAVALLARRADR
Mflv_3370|M.gilvum_PYR-GCK ---MASTDTAQLSGKVAFVTGGASGIGAALVAKLATAGTEVWIADRQIAP
MLBr_01094|M.leprae_Br4923 --------MEGFAGKVAVVTGAGSGIGQALAIELARSGAKLAISDVDGEG
::*.. *:* : . * * : :
MMAR_0387|M.marinum_M GKALAEEIGDAAR---YVHLDVTQPDQWEAAVATAVDEFGKLDVLVNNAG
MUL_1037|M.ulcerans_Agy99 GKALAEEIGDAAR---YVHLDVTQPDQWEAAVATAVDEFGKLDVLVNNVG
TH_4266|M.thermoresistible__bu LKKTAAEIEALGRRALAVPTDVTAPDECRALVDATVGEFGRLDVLVNNAG
MSMEG_3581|M.smegmatis_MC2_155 LDRIVEEIRSTGGAAVAVAVDVTRRADVDNLVATAVREFGRLDVLVNNAG
Mvan_3063|M.vanbaalenii_PYR-1 LHTLGGELRAAGAEVATVTTDVTAAGDLERLVGTAVADFGRLDVLVSNAG
Mb0788c|M.bovis_AF2122/97 LAELVDKIRADGGEAVAFPLDVTDPESVKSFVAQTVEALGEVELLVSSAG
Rv0765c|M.tuberculosis_H37Rv LAELVDKIRADGGEAVAFPLDVTDPESVKSFVAQTVEALGEVELLVSSAG
MAB_1215c|M.abscessus_ATCC_199 LTELVEKIRSDGGEAVAFPLDVTDADSVKSFVAESIDALGEIDLLVSGAG
MAV_2980|M.avium_104 LAELQAEIECSGGTALVVPADVTDAERVAAAVQRTVAEFGRLDILVNNAG
Mflv_3370|M.gilvum_PYR-GCK AEELAAQLRATGAVAHAVELDVRDPAAFAHAVHTAVDTSGRLDYLFNNAG
MLBr_01094|M.leprae_Br4923 LAQTEGQLKAIGASARTDRLDVTEREAFLTYADVVHENFGKVNQIYNNAG
:: . ** . *.:: : ...*
MMAR_0387|M.marinum_M IVALGQLKKFDLGKWQKVIDVNLTGTFLGMRAAVEPMTAAGS------GS
MUL_1037|M.ulcerans_Agy99 IVALGQLKKFDLGKWQKVIDVNLTGTFLGMRAAVEPMTAAGS------GS
TH_4266|M.thermoresistible__bu GGATKPLMKWTDDEWHEVLNLNLSSAWYLSRAAAKPMIDQGR------GA
MSMEG_3581|M.smegmatis_MC2_155 IATLGPLADGDTDTWSAVIDVNVRGVLHGIAAATPVFTCQGR------GH
Mvan_3063|M.vanbaalenii_PYR-1 ISAIGPLADADVTGWDAMIDVNLRGVLHGIAAAMPVFRQQGH------GH
Mb0788c|M.bovis_AF2122/97 DMLPGQLHEVSTEAFAEQVQIHLVGANRLATAVLPAMVARRR------GD
Rv0765c|M.tuberculosis_H37Rv DMLPGQLHEVSTEAFAEQVQIHLVGANRLATAVLPAMVARRR------GD
MAB_1215c|M.abscessus_ATCC_199 DMYPGRVHEMSAATFAAQIQVHLLGANQLATEVVPDMVSRRR------GD
MAV_2980|M.avium_104 LMQSGPATEASLRDWDRMVAVNVQGVLYATRAALPHLVDAAADSPRGVAD
Mflv_3370|M.gilvum_PYR-GCK IGIGGEVDTLTLDDWTDIIDVNLKGVIHGVHAAYPQMIRQGS------GH
MLBr_01094|M.leprae_Br4923 IAFTGDVEVSHFKDIERVMDVDYWGVVNGTKAFLPYLISSGD------GH
: :. .. : .
MMAR_0387|M.marinum_M IINVSSIEGLRGAPAVHPYVASKWAVRGLTKSAALELAPLN--IRVNSIH
MUL_1037|M.ulcerans_Agy99 IINVSSIEGLRGAPAVHPYVASKWAVRGLTKSAALELAPLN--IRVNSIH
TH_4266|M.thermoresistible__bu IVNISSGAGLLAMPQAPVYAAAKAGLNNLTGSMAAAWTRKG--VRVNCIA
MSMEG_3581|M.smegmatis_MC2_155 VITVVSTAGLKIVPEMGVYAGTKNAVRTIMEALRQESTDGV--IRTTSIS
Mvan_3063|M.vanbaalenii_PYR-1 FVTTVSTAGLKIVPTMGVYAATKNAVRTMMEALRQESTDGV--IRTTSIS
Mb0788c|M.bovis_AF2122/97 LIFVGSDVGLRQRPHMGAYGAAKAGLAAMVTNLQMELEGTG--VRASIVH
Rv0765c|M.tuberculosis_H37Rv LIFVGSDVGLRQRPHMGAYGAAKAGLAAMVTNLQMELEGTG--VRASIVH
MAB_1215c|M.abscessus_ATCC_199 VVFIGSDVALHQRPHMGAYGAAKAALLAMVNTMRMELEGTG--VRASIVH
MAV_2980|M.avium_104 LVTISSTAGWVARPNTAVYSLTKFGVNAFSEGIRQEVLGKR--VRVGVVG
Mflv_3370|M.gilvum_PYR-GCK IVNTASMAGLITTSAQGGYSATKHAVVALSKTMRVEAATHG--VRVSVLC
MLBr_01094|M.leprae_Br4923 VINISSVFGLFSVPGQAAYNSAKFAVRGFTEALREEMALAGRPVNVTTVY
.: * . . * :* .: : :.. :
MMAR_0387|M.marinum_M PGFIRTP-MTANLPD-----DMV-------------TIPLGRPAESREVS
MUL_1037|M.ulcerans_Agy99 PGFIRTP-MTANLPD-----DMV-------------TIPLGRPAESREVS
TH_4266|M.thermoresistible__bu CGAIRTPGLEADAKRQGFDIDMIGQ-----------TNGSGRIAEPDEIG
MSMEG_3581|M.smegmatis_MC2_155 PGYVRTELGGPPGGPAG-NAAR--------------ATMDRIGLPPDAVA
Mvan_3063|M.vanbaalenii_PYR-1 PGYVNTELDRSITDVALRNAVR--------------ADMDAFGLAPEAVA
Mb0788c|M.bovis_AF2122/97 PGPTLTGMGWQLSAEQV---GPMLADWA-----KWGQARHNYFLRPSDLA
Rv0765c|M.tuberculosis_H37Rv PGPTLTGMGWQLSAEQV---GPMLADWA-----KWGQARHNYFLRPSDLA
MAB_1215c|M.abscessus_ATCC_199 PGPTLTSMGWQLSAEQV---GPMLEDWK-----SWGQARHSYFLRPSDIA
MAV_2980|M.avium_104 PGTVDTEIFGHLSEPSR---EAFER-----------QTAGMVMLRPQDIA
Mflv_3370|M.gilvum_PYR-GCK PGVVRTPILTGGAFGRNKSVSREDQLKLGEALRPMDAGVFAQKALRGVLR
MLBr_01094|M.leprae_Br4923 PGGIKTAIARNATAAEGLDVSKIASRFDTWVAHTSPQHAARIILKAVRKK
* *
MMAR_0387|M.marinum_M TFVVFLASDDASYATGSEFVMDGGLVTDVPHKQF------------
MUL_1037|M.ulcerans_Agy99 TFVVFLASDDASYATGSEFVMDGGLVTDVPHKQF------------
TH_4266|M.thermoresistible__bu YGVLFFASDASSYCSGQTLYMHGGPGPAGV----------------
MSMEG_3581|M.smegmatis_MC2_155 RAIAFAIEQPHDVEIGDLTIRPTVQG--------------------
Mvan_3063|M.vanbaalenii_PYR-1 RAIVFAIEQPPEVEIGDLTIRPAVQG--------------------
Mb0788c|M.bovis_AF2122/97 RAIAFVAETPRGCVVVNMEIQPEAPLRDAPAHRQKLVLGEEGMPG-
Rv0765c|M.tuberculosis_H37Rv RAIAFVAETPRGCVVVNMEIQPEAPLRDAPAHRQKLVLGEEGMPG-
MAB_1215c|M.abscessus_ATCC_199 RAVTFVAETPRGAHIPEMEVQPEAPLKDAPADKQKLELGEEGMPS-
MAV_2980|M.avium_104 DAVLFMVTRDRRVAVNHMLVRAAEQTW-------------------
Mflv_3370|M.gilvum_PYR-GCK NEAIIVVPRWWKALWYLERLSPALSMRTAAVALKRTREVQSAVPLQ
MLBr_01094|M.leprae_Br4923 KARVLVGPDAKVANVVVRFSGGAGYQRLFAQVASRLILNQR-----
: