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MARPEPFVHITPDEQLDDLRRRLRATRWNDAPEDAVWSIGADSGYLRELVDYWVDEFDWRQRELELNALP RFRASLDGLGIHFVHARAVEGSPAPVPLILTHGWPDSFWRYAKVLALLTDPASHGGDPADAFDVVVPDLP GFGYSDRPRIPALNAAEVAALWSRLMTALGYPRYGAVGGDIGSSVSRFLALDFPEQVVAVHRMDAGLPAG TAELGDLSEDERRWIKEATRWVGAEGAYAAMHRTKPQTAAVGLTDSPAGLAAWIVEKMRAWSDCGGDVES VFSKDDLLTNVTVYWMTATISSSMRMYRANAAIPVEQYARRVEVPTGYSLFRGDIVRPPHAWLHRTSNAV YITEPPRGGHFAPYEQPELYAEELRNFFRPYRNHT
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_0182 | - | - | 100% (385) | epoxide hydrolase 1 |
| M. smegmatis MC2 155 | MSMEG_6858 | - | 2e-82 | 43.80% (379) | epoxide hydrolase 1 |
| M. smegmatis MC2 155 | MSMEG_5658 | - | 1e-76 | 39.84% (379) | epoxide hydrolase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1864c | - | 8e-06 | 29.81% (104) | haloalkane dehalogenase |
| M. gilvum PYR-GCK | Mflv_0644 | - | 4e-79 | 40.74% (378) | epocide hydrolase domain-containing protein |
| M. tuberculosis H37Rv | Rv0134 | ephF | 5e-08 | 28.38% (148) | epoxide hydrolase EphF |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4300 | - | 1e-07 | 30.48% (105) | putative hydrolase, alpha/beta fold |
| M. marinum M | MMAR_3314 | - | 2e-80 | 41.53% (378) | hydrolase |
| M. avium 104 | MAV_2202 | - | 6e-82 | 43.01% (379) | epoxide hydrolase |
| M. thermoresistible (build 8) | TH_2132 | - | 1e-37 | 45.91% (159) | epoxide hydrolase 1 |
| M. ulcerans Agy99 | MUL_4778 | ephF | 1e-08 | 27.89% (147) | epoxide hydrolase EphF |
| M. vanbaalenii PYR-1 | Mvan_0521 | - | 5e-79 | 40.74% (378) | epocide hydrolase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_3314|M.marinum_M ------MRPFRIDVPDDVIDDLKARLTRTRWPEAECVDDWSQGIPLSYTR
MAV_2202|M.avium_104 ------MKPFRIDVPDDVLDDLRARLARTRWPEAECVDDWSQGMPLAYTR
Mflv_0644|M.gilvum_PYR-GCK ---MRAVRPFSIHVADDVLDDLRTRLSRTRWPEAECVPDWTQGIPLGYTR
Mvan_0521|M.vanbaalenii_PYR-1 MSAVRAVRPFSIHVADDVLDDLRTRLSRTRWPEAECVPDWTQGIPLGYTR
TH_2132|M.thermoresistible__bu ---MPSVKPFRIAVPDDDLDDLRHRLARTRWPDRECVDDWGQGVPLDYVR
MSMEG_0182|M.smegmatis_MC2_155 ---MARPEPFVHITPDEQLDDLRRRLRATRWNDAPEDAVWSIGADSGYLR
Rv0134|M.tuberculosis_H37Rv --------------------------------------------------
MUL_4778|M.ulcerans_Agy99 --------------------------------------------------
Mb1864c|M.bovis_AF2122/97 --------------------------------------------------
MAB_4300|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_3314|M.marinum_M DLAAYWANEYDWRAREAALNRFDQFITEIDGLDLHFIHQRSP--HQDAFP
MAV_2202|M.avium_104 ELADYWANDYDWRAREAALNRFDQFVTEIDGLDIHFIHQRSP--HADAFP
Mflv_0644|M.gilvum_PYR-GCK ELAAYWADGYDWRSREAALNRFDQFVVEIHGVDIHFIHQRSP--HQEAFP
Mvan_0521|M.vanbaalenii_PYR-1 ELAAYWADGYDWRSREAALNRFDQFVVEIHGVDIHFIHQRSP--HQEAFP
TH_2132|M.thermoresistible__bu DLAGYWADGYDWRAREAALNRFDQFITELDGLDIHFIHQRSP--HPDAFP
MSMEG_0182|M.smegmatis_MC2_155 ELVDYWVDEFDWRQRELELNALPRFRASLDGLGIHFVHARAVEGSPAPVP
Rv0134|M.tuberculosis_H37Rv ------------MIALPALEGVEHRHVDVAEGVRIHVADAGP---ADGPA
MUL_4778|M.ulcerans_Agy99 ------------MSTLPALDGVEHRFVDLDGGITIHVADAGP---ADGPA
Mb1864c|M.bovis_AF2122/97 --------MSIDFTPDPQLYPFESRWFDSSRGRIHYVDEGTG------PP
MAB_4300|M.abscessus_ATCC_1997 ------------MDAELEEWKAAGHYFDYLGFDIFYRVEGSG------PP
. . .
MMAR_3314|M.marinum_M LLITHGWPGSVVEFHKVIEPLTNPTAHGGRAEDAFHVVCPSLPGYGFSGK
MAV_2202|M.avium_104 LLITHGWPGSIVEFHKVIEPLTNPAS--GRGEDAFHVVCPSLPGYGFSGK
Mflv_0644|M.gilvum_PYR-GCK LVITHGWPGSIVEFHNVIEPLTNPTAHGGRAEDAFHVVCPALPGYGFSGK
Mvan_0521|M.vanbaalenii_PYR-1 LVITHGWPGSIVEFHNVIEPLTNPTAHGGRAEDAFHVVCPALPGYGFSGK
TH_2132|M.thermoresistible__bu LLITHGWPGSIVEFHKVIGPLTDPTAHGGTAADAFHVVCPSLPGYGFSGK
MSMEG_0182|M.smegmatis_MC2_155 LILTHGWPDSFWRYAKVLALLTDPASHGGDPADAFDVVVPDLPGFGYSDR
Rv0134|M.tuberculosis_H37Rv VMLVHGFPQNWWEWRDLIGPLA---------ADGNRVLCPDLRGAGWSSA
MUL_4778|M.ulcerans_Agy99 VMLVHGFPENWWEWHELIGPLA---------ADGYRVLCPDLRGAGWSSA
Mb1864c|M.bovis_AF2122/97 ILLCHGNPTWSFLYRDIIVALR----------DRFRCVAPDYLGFGLSER
MAB_4300|M.abscessus_ATCC_1997 LLLIHGYPFNSWDWALIWPTLV----------ERFTVIAPDMIGMGFSDK
::: ** * : : * : : * * * *
MMAR_3314|M.marinum_M PSSTGWGVDRIARAWETLMQNLGYQRYGAQGGDWGAAVTTQIGRNGGRCV
MAV_2202|M.avium_104 PTRAGWGVERIARAWETLMLRLGYQRYGAQGGDWGAAVTTQIGRNRGHCV
Mflv_0644|M.gilvum_PYR-GCK PTNAGWGVGKIAQAWETLMLRLGYQRYGAQGGDWGAAITTQMGRNRGHCA
Mvan_0521|M.vanbaalenii_PYR-1 PTNAGWGVGKIAQAWETLMLRLGYQRYGAQGGDWGAAITTQMGRNRGHCA
TH_2132|M.thermoresistible__bu PTTTGWGVGRIATXXX----------------------------------
MSMEG_0182|M.smegmatis_MC2_155 PRIPALNAAEVAALWSRLMTALGYPRYGAVGGDIGSSVSRFLALDFPEQV
Rv0134|M.tuberculosis_H37Rv PR-SRYTKTEMADDLAAVLDGLGVAKVKLVAHDWGGPVAFIMMLRHPEKV
MUL_4778|M.ulcerans_Agy99 PR-SRYTKKEMADDLAGVLDRLGIASVRLVAHDWGGPVAFIMMLRYPAKV
Mb1864c|M.bovis_AF2122/97 PSGFGYQIDEHARVIGEFVDHLGLDRYLSMGQDWGGPISMAVAVERADRV
MAB_4300|M.abscessus_ATCC_1997 PVQYGYSVLDHADMHEALLSYLGIERFHLLTHDLGNSVGQEMLARFEFEQ
* *
MMAR_3314|M.marinum_M AIHLNMPIAMPT-RTALTNPTAAEQEVLAALAYHRKWGTGYFKQQSTRPQ
MAV_2202|M.avium_104 AIHLNMPIGRPG-QEALTNPTEQERAALAALANHRKRGTGYSKQQSTRPQ
Mflv_0644|M.gilvum_PYR-GCK AIHLNMPIAYPP-AGGITDPTEEEQLALAALTTYQRWETGYSEQQSTRPQ
Mvan_0521|M.vanbaalenii_PYR-1 AIHLNMPIAYPP-AGGITDPTEEEQLALAALTTYQRWETGYSEQQSTRPQ
TH_2132|M.thermoresistible__bu -------------AARAPRPT--------SIRPWRRRCTG-----TTTP-
MSMEG_0182|M.smegmatis_MC2_155 VAVHRMDAGLPAGTAELGDLSEDERRWIKEATRWVGAEGAYAAMHRTKPQ
Rv0134|M.tuberculosis_H37Rv TGFFGVNTVAPWVKRDLGMLRNMWRFWYQIPMSLPVIGPRVISDPKGRYF
MUL_4778|M.ulcerans_Agy99 TGFFGMNTAAPWFPRDLGMVRDIWRFWYQIPILLPVIGPRVIADPKARYF
Mb1864c|M.bovis_AF2122/97 RGVVLGNTWFWP--ADTLAMKAFSRVMSSPPVQYAILRRNFFVERLIPAG
MAB_4300|M.abscessus_ATCC_1997 QSRGRVPIDSVTWLNGGLFIEAYRPRIAQTLMSRTPLGDLVSRFQGTPVT
MMAR_3314|M.marinum_M TVGYGLTDSPVGQLAWIVEKFWAWMDCAGNPENVLTRDELLDNVMMYWVN
MAV_2202|M.avium_104 TLGYGLADSPVGQLAWIVEKFWDWADCDGHPENALSRDELLDNVMVYWVT
Mflv_0644|M.gilvum_PYR-GCK TVGYGLADSPVGQMAWIVEKFAAWMDCDGHPENVLSRDELLDNVMMYWAT
Mvan_0521|M.vanbaalenii_PYR-1 TVGYGLADSPVGQMAWIVEKFAAWMDCDGHPENVLSRDELLDNVMMYWAT
TH_2132|M.thermoresistible__bu --------------------------------------------------
MSMEG_0182|M.smegmatis_MC2_155 TAAVGLTDSPAGLAAWIVEKMRAWSDCGGDVESVFSKDDLLTNVTVYWMT
Rv0134|M.tuberculosis_H37Rv RLLTGWVG---GGFRVPDDDVRLYLDCMREPGHAEAG-------SRWYRT
MUL_4778|M.ulcerans_Agy99 RVLTSWVG---GGFTIADEDVRMYVERMRQPGHAVAG-------SRWYRT
Mb1864c|M.bovis_AF2122/97 TEHR-PSSAVMAHYRAVQPNAAARRGVAEMPKQILAARPLLARLAREVPA
MAB_4300|M.abscessus_ATCC_1997 ---RRIMDAAVSEMFGPDTKPSPRLLSLFQQVLEYNDGARVTHQVGRFIN
MMAR_3314|M.marinum_M AAAASSARLYWE--SFKVWGQTERVELPTGVASFPKEVLRAPRAWCEPNY
MAV_2202|M.avium_104 NTAASSARLYWE--SFSAWGGGDRVELPTGVAAFPGELLKAPRSWCEPAY
Mflv_0644|M.gilvum_PYR-GCK NSGSSSARLYWE--SFKTLDATTRVELPTGIAAFPKEVLRAPRSWCEPIY
Mvan_0521|M.vanbaalenii_PYR-1 NSGSSSARLYWE--SFKTLDATTRVELPTGIAAFPKEVLRAPRSWCEPIY
TH_2132|M.thermoresistible__bu --------------------------------------------------
MSMEG_0182|M.smegmatis_MC2_155 ATISSSMRMYRANAAIPVEQYARRVEVPTGYSLFRGDIVRPPHAWLHRTS
Rv0134|M.tuberculosis_H37Rv FQTREMLRWLRG------EYNDARVDVPVRWLHGTGDPVITPDLLDGYAE
MUL_4778|M.ulcerans_Agy99 FQSSEALPWMRG------EYADARVDVPVRWLHGTDDPVLTPQLLRGYED
Mb1864c|M.bovis_AF2122/97 TLGTKPTLLIWG---------------------MKDVAFRPKTIIPRLSA
MAB_4300|M.abscessus_ATCC_1997 DRYDNRSRWVRA---------MRETAVPMRMIDGPIDPNSGLHMAERYLE
MMAR_3314|M.marinum_M NITHWTTMPRG---GHFAAFEQPELFVGDVRAFFATVR----
MAV_2202|M.avium_104 NITHWTDMPRG---GHFAAFEQPELFVEDLRVFFATVR----
Mflv_0644|M.gilvum_PYR-GCK NITHWTTMPRG---GHFAALEQPRLFVDDIRAFFESVR----
Mvan_0521|M.vanbaalenii_PYR-1 NITHWTTMPRG---GHFAALEQPRLFVDDIRAFFESVR----
TH_2132|M.thermoresistible__bu ------------------------------------------
MSMEG_0182|M.smegmatis_MC2_155 NAVYITEPPRG---GHFAPYEQPELYAEELRNFFRPYRNHT-
Rv0134|M.tuberculosis_H37Rv RASDFEVELVDG-VGHWIVEQRPELVLDRVRAFLAAGTEQRD
MUL_4778|M.ulcerans_Agy99 HISDFEVEFVDG-VGHWIVEQRPDLVLDRLRAFLRIET----
Mb1864c|M.bovis_AF2122/97 TFPDHVLVELPN-AKHFIQEDAPDRIAAAIIERFG-------
MAB_4300|M.abscessus_ATCC_1997 VIHDPDVVLLDDNIGHWPQIEAPEAVLTHFLEHIDRITP---