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MIALPALEGVEHRHVDVAEGVRIHVADAGPADGPAVMLVHGFPQNWWEWRDLIGPLAADGNRVLCPDLRG AGWSSAPRSRYTKTEMADDLAAVLDGLGVAKVKLVAHDWGGPVAFIMMLRHPEKVTGFFGVNTVAPWVKR DLGMLRNMWRFWYQIPMSLPVIGPRVISDPKGRYFRLLTGWVGGGFRVPDDDVRLYLDCMREPGHAEAGS RWYRTFQTREMLRWLRGEYNDARVDVPVRWLHGTGDPVITPDLLDGYAERASDFEVELVDGVGHWIVEQR PELVLDRVRAFLAAGTEQRD
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv0134 | ephF | - | 100% (300) | POSSIBLE EPOXIDE HYDROLASE EPHF (EPOXIDE HYDRATASE) (ARENE-OXIDE HYDRATASE) |
| M. tuberculosis H37Rv | Rv3617 | ephA | 1e-25 | 30.22% (321) | epoxide hydrolase EphA |
| M. tuberculosis H37Rv | Rv1938 | ephB | 7e-21 | 41.88% (117) | epoxide hydrolase EphB |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1973 | ephB | 6e-21 | 41.88% (117) | epoxide hydrolase EphB |
| M. gilvum PYR-GCK | Mflv_1960 | - | 1e-42 | 36.47% (266) | alpha/beta hydrolase fold |
| M. leprae Br4923 | MLBr_00862 | ephD | 1e-20 | 33.69% (187) | short chain dehydrogenase |
| M. abscessus ATCC 19977 | MAB_4522c | - | 1e-52 | 37.46% (291) | epoxide hydrolase EphF |
| M. marinum M | MMAR_0342 | ephF | 1e-144 | 78.38% (296) | epoxide hydrolase EphF |
| M. avium 104 | MAV_5163 | - | 1e-144 | 79.05% (296) | hydrolase, alpha/beta fold family protein |
| M. smegmatis MC2 155 | MSMEG_6719 | - | 4e-27 | 31.93% (285) | epoxide hydrolase |
| M. thermoresistible (build 8) | TH_2421 | - | 6e-49 | 40.15% (274) | PUTATIVE alpha/beta hydrolase fold |
| M. ulcerans Agy99 | MUL_4778 | ephF | 1e-144 | 78.38% (296) | epoxide hydrolase EphF |
| M. vanbaalenii PYR-1 | Mvan_4764 | - | 4e-42 | 34.31% (306) | alpha/beta hydrolase fold |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_0342|M.marinum_M --MSTLPALDGVEHRFVDLDGGITIHVADAGPAD--GPAVMLVHGFPENW
MUL_4778|M.ulcerans_Agy99 --MSTLPALDGVEHRFVDLDGGITIHVADAGPAD--GPAVMLVHGFPENW
Rv0134|M.tuberculosis_H37Rv --MIALPALEGVEHRHVDVAEGVRIHVADAGPAD--GPAVMLVHGFPQNW
MAV_5163|M.avium_104 --MVTMPELDGVEHRYVDLGDDVTIHVADAGPAS--GPAVMLVHGFPQNW
Mflv_1960|M.gilvum_PYR-GCK ----------------MTVRG-VDFHITEAGPED--GRPVLALHGWPQHH
Mvan_4764|M.vanbaalenii_PYR-1 -MTDQPPPIDGVRRHFVTARG-VNFHVTEAGPED--GRPVLALHGWPQHH
TH_2421|M.thermoresistible__bu -----------VRRSFVEARG-VRFHVTESGPAD--GRPVLALHGWPQHH
MAB_4522c|M.abscessus_ATCC_199 MTQRSMPVLDGVEHQYVQAGD-VKIHVAVAGPQD--GRAVVLLHGWPENW
Mb1973|M.bovis_AF2122/97 ---------MSQVHRILNCRG-TRIHAVADSPPDQQGPLVVLLHGFPESW
MSMEG_6719|M.smegmatis_MC2_155 ---MTTSGSVALRHVRQQVRPDVSLHAVIAGSGP----AVFLLHGWPQTW
MLBr_00862|M.leprae_Br4923 --MPATQSIHKVPHQFVESPDGVRLAIYQSGQPE--GPAIVLVHGFPDSH
: . :. :**:*:
MMAR_0342|M.marinum_M WEWHELIGPLAAD----------GYRVLCPDLRGAGWSS--APRSRYTKK
MUL_4778|M.ulcerans_Agy99 WEWHELIGPLAAD----------GYRVLCPDLRGAGWSS--APRSRYTKK
Rv0134|M.tuberculosis_H37Rv WEWRDLIGPLAAD----------GNRVLCPDLRGAGWSS--APRSRYTKT
MAV_5163|M.avium_104 WEWRALIGPLAAD----------GYRVLCPDLRGAGWSS--APRSSYRKD
Mflv_1960|M.gilvum_PYR-GCK WAYRDLLGDPP-----------PGLRIIAPDLPGYGWSG--PPPHRWAKE
Mvan_4764|M.vanbaalenii_PYR-1 WVYRSLLADPPTSAGASSRLPEPGLRIIAPDLPGYGWSG--PAPHKWAKE
TH_2421|M.thermoresistible__bu WAYRDLLADPP-----------AGLRIIAPDLPGYGWSG--PAPHRWAKE
MAB_4522c|M.abscessus_ATCC_199 WMWHKVIPALAA----------AGYRVHAMDLRGAGWSE--VAPAGYEKE
Mb1973|M.bovis_AF2122/97 YSWRHQIPALAG----------AGYRVVAIDQRGYGRSSKYRVQKAYRIK
MSMEG_6719|M.smegmatis_MC2_155 QEWLPILEDLAR-----------HHTVVAVDLKGAGGSS--KPLLGYDKV
MLBr_00862|M.leprae_Br4923 VLWDGVVPLLAKR-----------FRIVRYDNRGVGQSSVPKPVSAYTMT
: : . : * * * * :
MMAR_0342|M.marinum_M EMADDLAGVLDRLGIAS-VRLVAHDWG--GPVAFIMMLRYPAKVTGFFGM
MUL_4778|M.ulcerans_Agy99 EMADDLAGVLDRLGIAS-VRLVAHDWG--GPVAFIMMLRYPAKVTGFFGM
Rv0134|M.tuberculosis_H37Rv EMADDLAAVLDGLGVAK-VKLVAHDWG--GPVAFIMMLRHPEKVTGFFGV
MAV_5163|M.avium_104 EMADDLAGVLDRLGVRS-VDLVAHDWG--GPVAFIMMLRHPEKVTGFFGV
Mflv_1960|M.gilvum_PYR-GCK DVVTDLVALVDALGLDR-FLLVGHDWG--GYIGHLLALRIPERIDAYLAL
Mvan_4764|M.vanbaalenii_PYR-1 DVVSDLVALMDAMGLDR-VLLIGHDWG--GYIGHLLAMRVPERIDGYLAL
TH_2421|M.thermoresistible__bu DVASDLLALMDELGLGR-TLLIGHDWG--GYIGFLMILRAPERFDGYIPL
MAB_4522c|M.abscessus_ATCC_199 QFASDVLAAADALGLES-FDLVGHDWG--GWTAQLVALKAQSRIRRLVVL
Mb1973|M.bovis_AF2122/97 ELVGDVVGVLDSYGAEQ-AFVVGHDWG--APVAWTFAWLHPDRCAGVVGI
MSMEG_6719|M.smegmatis_MC2_155 TMAEELDILREKLGFDT-VQVVGHDIG--GMLAYAWAATHRDTVTRLAVF
MLBr_00862|M.leprae_Br4923 RFADDFAAVIDELSPDRPVHVLAHDWGSVGVWEYLSRSGASDRVASFTSV
.. :. : . ::.** * . .
MMAR_0342|M.marinum_M NTAAP--------------WFPRDLG-MVRDIWRFWYQIPIMLPVIGPRV
MUL_4778|M.ulcerans_Agy99 NTAAP--------------WFPRDLG-MVRDIWRFWYQIPILLPVIGPRV
Rv0134|M.tuberculosis_H37Rv NTVAP--------------WVKRDLG-MLRNMWRFWYQIPMSLPVIGPRV
MAV_5163|M.avium_104 NTSAP--------------FVKRSLS-TIRNVWRFWYQIPISLPVIGPRV
Mflv_1960|M.gilvum_PYR-GCK NIAHP--------------WVPPKV------MAPHLWRFLLYQPVVASAG
Mvan_4764|M.vanbaalenii_PYR-1 NIAHP--------------WVPPKV------MAPHLWRFLQYQPLVAFAG
TH_2421|M.thermoresistible__bu NIAHP--------------WVSTGT------VLKHIWRFS-YQPPMAAFG
MAB_4522c|M.abscessus_ATCC_199 NIPPV--------------WQQPGR------VARYAHKLA-YQLVVGAPV
Mb1973|M.bovis_AF2122/97 SVPFAGRGVIGLPGSPFGERRPSDYH-LELAGPGRVWYQDYFAVQDGIIT
MSMEG_6719|M.smegmatis_MC2_155 DVPIP----------------GASLW-DGILTDPLAWHFAFHQCRDVPEF
MLBr_00862|M.leprae_Br4923 SGPSQDQLVDYILSGLRRPWRPRTFARAVSQLFRLTYMVLFSIPVLVPMV
.
MMAR_0342|M.marinum_M IADPKARYFRVLTSWVGGGFTIADED------------------VRMYVE
MUL_4778|M.ulcerans_Agy99 IADPKARYFRVLTSWVGGGFTIADED------------------VRMYVE
Rv0134|M.tuberculosis_H37Rv ISDPKGRYFRLLTGWVGGGFRVPDDD------------------VRLYLD
MAV_5163|M.avium_104 ISTPDSRFVRLLGSWVGGGYTLPEED------------------VRLYLE
Mflv_1960|M.gilvum_PYR-GCK VPLQTRTRYLEKVVFRAAAPKLDAAT------------------VGTYAE
Mvan_4764|M.vanbaalenii_PYR-1 VPLQRHTSFLKR-AYKLAAPKLDPQT------------------VRVYSE
TH_2421|M.thermoresistible__bu VPLQQRTRVLERVVFGKGS-ALDAET------------------AKVYAD
MAB_4522c|M.abscessus_ATCC_199 VGPLSHLSPTLWWFIRRSG--MPKES------------------VDFFRS
Mb1973|M.bovis_AF2122/97 EIEEDLRGWLLGLTYTVSGEGMMAATKAAV-------------DAGVDLE
MSMEG_6719|M.smegmatis_MC2_155 LIAGRERGYVEYFLRGRTANQDAFTD---A-------------AVDHYAH
MLBr_00862|M.leprae_Br4923 LWIALSSATIRRTMVDNISTDQIHHSATLARDAAHSVKTYPANYFRAFSG
.
MMAR_0342|M.marinum_M RMRQPGHAVAG---------------------------SRWYRTFQSSEA
MUL_4778|M.ulcerans_Agy99 RMRQPGHAVAG---------------------------SRWYRTFQSSEA
Rv0134|M.tuberculosis_H37Rv CMREPGHAEAG---------------------------SRWYRTFQTREM
MAV_5163|M.avium_104 CMRQPGHAEAG---------------------------SRWYRSFQTREM
Mflv_1960|M.gilvum_PYR-GCK RFRDPVVARTA---------------------------RDTYRTFLTREI
Mvan_4764|M.vanbaalenii_PYR-1 RFRDPVVARTA---------------------------RDTYRTFLLREA
TH_2421|M.thermoresistible__bu RFRDPVCARAG---------------------------RDTYRTFLVREM
MAB_4522c|M.abscessus_ATCC_199 CFRDRDRRVAG---------------------------SKIYRSMVGKEF
Mb1973|M.bovis_AF2122/97 SMDPIDVIRAGPLCMAEG-----------ARLKDAFVYPETMPAWFTEAD
MSMEG_6719|M.smegmatis_MC2_155 ALAQPGAVRST---------------------------LEWYRAFAQDAD
MLBr_00862|M.leprae_Br4923 RRRGKGVPVVNVPVQLIVNTMDRYVRPYGYDATARWVPRLWRRDIKAGHF
MMAR_0342|M.marinum_M LPWMRGEYADARVDVPVRWLHGTE-------------DPVLTPQLLRG--
MUL_4778|M.ulcerans_Agy99 LPWMRGEYADARVDVPVRWLHGTD-------------DPVLTPQLLRG--
Rv0134|M.tuberculosis_H37Rv LRWLRGEYNDARVDVPVRWLHGTG-------------DPVITPDLLDG--
MAV_5163|M.avium_104 LSWMRGEYDGARVHVPVRWLSGTE-------------DPVLTPDLLDG--
Mflv_1960|M.gilvum_PYR-GCK PKGVRDG-ERRWSTVPTRVLFGRS-------------DTAIHPDLAAA--
Mvan_4764|M.vanbaalenii_PYR-1 PAAIRNG-ERRRSKVPTRALFGRD-------------DAAIHPSLAAA--
TH_2421|M.thermoresistible__bu PAAARNP-EKRRATVPIRALFGTR-------------DLAIHPSLAAP--
MAB_4522c|M.abscessus_ATCC_199 ANLARGPYDDQKLTMPVRVLFGLD-------------DVAVHPSLLDG--
Mb1973|M.bovis_AF2122/97 LDFYTGEFERSGFGGPLSFYHNIDNDWHDLADQQG--KPLTPPALFIGGQ
MSMEG_6719|M.smegmatis_MC2_155 D---NRKLAREPLTVPVLALGGEH---------------RWGPKMVDV--
MLBr_00862|M.leprae_Br4923 SPMSHPQVMAAAVHDLADLVDGKQPSRALLRAQVGRSRDTFGDTLVSVTG
. :
MMAR_0342|M.marinum_M ------------------------YEDHISDFEVEFVDGVG----HWIVE
MUL_4778|M.ulcerans_Agy99 ------------------------YEDHISDFEVEFVDGVG----HWIVE
Rv0134|M.tuberculosis_H37Rv ------------------------YAERASDFEVELVDGVG----HWIVE
MAV_5163|M.avium_104 ------------------------YAERIDDFQLELVDGVG----HWIVD
Mflv_1960|M.gilvum_PYR-GCK ------------------------ETARADDYTI-DVVDGG----HFILD
Mvan_4764|M.vanbaalenii_PYR-1 ------------------------ETARADDYTI-DVVDGG----HFILD
TH_2421|M.thermoresistible__bu ------------------------ETALADDYTL-ETVDCS----HFIVD
MAB_4522c|M.abscessus_ATCC_199 ------------------------FKDHADDLNITEVPNCG----HFIVD
Mb1973|M.bovis_AF2122/97 YDVGT---------IWGAQAIERAHEVMPNYRGTHMIADVG----HWIQQ
MSMEG_6719|M.smegmatis_MC2_155 ------------------------LREFATDVRGGSIPDCG----HWVVE
MLBr_00862|M.leprae_Br4923 AGSGIGRETALALARRGAEVVVSDIDEAAAKNTAAQIVASGGVAYAYALD
. : :
MMAR_0342|M.marinum_M QRPDLVLDRLRAFLRIET--------------------------------
MUL_4778|M.ulcerans_Agy99 QRPDLVLDRLRAFLRIET--------------------------------
Rv0134|M.tuberculosis_H37Rv QRPELVLDRVRAFLAAGTEQRD----------------------------
MAV_5163|M.avium_104 QRPDLVLDRVRAFLRRET--------------------------------
Mflv_1960|M.gilvum_PYR-GCK EQPDLVRAKLIAVADEFPERPVR---------------------------
Mvan_4764|M.vanbaalenii_PYR-1 EQPELVRAKLIALAEEFPAR------------------------------
TH_2421|M.thermoresistible__bu ERPDLVRARLVALAEETA--------------------------------
MAB_4522c|M.abscessus_ATCC_199 EQPELVVKWLSEVLAEPAP-------------------------------
Mb1973|M.bovis_AF2122/97 EAPEETNRLLLDFLGGLRP-------------------------------
MSMEG_6719|M.smegmatis_MC2_155 ERPDVVLAELEAFLQR----------------------------------
MLBr_00862|M.leprae_Br4923 VSDAAAVEAFAEQVSAKHGVPDIVVNNAGIGQAGRFLDTPPEEFDRVLAV
. .
MMAR_0342|M.marinum_M --------------------------------------------------
MUL_4778|M.ulcerans_Agy99 --------------------------------------------------
Rv0134|M.tuberculosis_H37Rv --------------------------------------------------
MAV_5163|M.avium_104 --------------------------------------------------
Mflv_1960|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4764|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_2421|M.thermoresistible__bu --------------------------------------------------
MAB_4522c|M.abscessus_ATCC_199 --------------------------------------------------
Mb1973|M.bovis_AF2122/97 --------------------------------------------------
MSMEG_6719|M.smegmatis_MC2_155 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 NLGGVVNCCRAFGQRLVERGTGGHIVNVSSMAAYAPLQSLSAYCTSKAAT
MMAR_0342|M.marinum_M --------------------------------------------------
MUL_4778|M.ulcerans_Agy99 --------------------------------------------------
Rv0134|M.tuberculosis_H37Rv --------------------------------------------------
MAV_5163|M.avium_104 --------------------------------------------------
Mflv_1960|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4764|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_2421|M.thermoresistible__bu --------------------------------------------------
MAB_4522c|M.abscessus_ATCC_199 --------------------------------------------------
Mb1973|M.bovis_AF2122/97 --------------------------------------------------
MSMEG_6719|M.smegmatis_MC2_155 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 YMFSDCLRAELDAVGVGLTTICPGVIDTNIIQSTRIDTPTAKQERVRDRR
MMAR_0342|M.marinum_M --------------------------------------------------
MUL_4778|M.ulcerans_Agy99 --------------------------------------------------
Rv0134|M.tuberculosis_H37Rv --------------------------------------------------
MAV_5163|M.avium_104 --------------------------------------------------
Mflv_1960|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4764|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_2421|M.thermoresistible__bu --------------------------------------------------
MAB_4522c|M.abscessus_ATCC_199 --------------------------------------------------
Mb1973|M.bovis_AF2122/97 --------------------------------------------------
MSMEG_6719|M.smegmatis_MC2_155 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 GQLDMMFRLRRYGPDKVADTILSAIKKNKPIRPVAPEAYALYGISRVLPQ
MMAR_0342|M.marinum_M -----------
MUL_4778|M.ulcerans_Agy99 -----------
Rv0134|M.tuberculosis_H37Rv -----------
MAV_5163|M.avium_104 -----------
Mflv_1960|M.gilvum_PYR-GCK -----------
Mvan_4764|M.vanbaalenii_PYR-1 -----------
TH_2421|M.thermoresistible__bu -----------
MAB_4522c|M.abscessus_ATCC_199 -----------
Mb1973|M.bovis_AF2122/97 -----------
MSMEG_6719|M.smegmatis_MC2_155 -----------
MLBr_00862|M.leprae_Br4923 VLRSTARIRVI