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TSPLWMASPPEVHSSLLSTGPGPGGILVAAAGWLSLGALFEATAAEVDHQICEAIRLWQGRAADDYVAAH TPYVVWLDHAAIVCQRAGAALQMMVAAYGDALAEMPTMAELQENHAVHGVLVATNFFGLNGVPIAVNEAD YVRMWIQAAGVMGVYESCTSAALLEVRPTCPSPVLVNPGVEGVGNATSWSGFADSDEFSVSSFNDGVLGL DVAVAGELCEFDPFDGLDLDGCQLVSVSTTQGFGAAMDVTAAPGSPLSGAALAPTGHICAGVPLATSTPL GVTRHVGDLQMMAARDNSDRAVVDAPHEILVSDSRGGTAQSGASGSVRPGVGSASVVQAASPGRPVSELA GGRGAGTVGFAGVSATGTKVRPAGLSATGGGEFGSGAGVPVLPATWPLQVVGSTSGSGVSPPAL*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_2932 | - | - | 100% (415) | PPE family protein |
| M. ulcerans Agy99 | MUL_2245 | - | 2e-76 | 40.42% (428) | PPE family protein |
| M. ulcerans Agy99 | MUL_0492 | - | 3e-58 | 36.71% (414) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3047c | PPE47 | 1e-62 | 36.34% (443) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0325 | - | 4e-48 | 48.73% (197) | PPE protein |
| M. tuberculosis H37Rv | Rv3018c | PPE46 | 1e-61 | 35.32% (453) | PPE family protein |
| M. leprae Br4923 | MLBr_01828 | PPE | 5e-40 | 47.88% (165) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_0669 | - | 3e-55 | 32.26% (465) | PPE-family protein |
| M. marinum M | MMAR_2806 | - | 0.0 | 98.31% (415) | PPE family protein |
| M. avium 104 | MAV_2429 | - | 1e-54 | 36.88% (404) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 1e-52 | 52.36% (191) | PPE family protein |
| M. thermoresistible (build 8) | TH_3569 | - | 4e-48 | 48.40% (188) | PUTATIVE PPE protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 9e-52 | 35.29% (425) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE
MSMEG_0619|M.smegmatis_MC2_155 ----------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAE
TH_3569|M.thermoresistible__bu ---------MMTAPIWMALPPEVHSALLSSGPGPGSLLAAASAWHALSAE
MAV_2429|M.avium_104 ----------MTAPVWIAFPPEVHSTLLSSGPGPAPLLAAATAWSSMSTE
MLBr_01828|M.leprae_Br4923 ----------MSAPIWMASPPEVHSALLSRGPGSGPLLVAAEAWRSLSSV
MAB_0669|M.abscessus_ATCC_1997 ----------MTAPIWMAEPPEVHSALLSAGPGPGAVLAAAVQWQEIGNN
Mb3047c|M.bovis_AF2122/97 ----------MTAPVWLASPPEVHSALLSAGPGPGSLQAAAAGWSALSAE
Rv3018c|M.tuberculosis_H37Rv ----------MTAPVWLASPPEVHSALLSAGPGPGSLQAAAAGWSALSAE
MUL_2932|M.ulcerans_Agy99 ----------MTSPLWMASPPEVHSSLLSTGPGPGGILVAAAGWLSLGAL
MMAR_2806|M.marinum_M ----------MTSPLWMASPPEVHSSLLSTGPGPGGILVAAAGWLSLGAL
:::*:*:* ******::** ***.. : .*. * :.
Mflv_0325|M.gilvum_PYR-GCK YASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA
Mvan_0415|M.vanbaalenii_PYR-1 YAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA
MSMEG_0619|M.smegmatis_MC2_155 YAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAA
TH_3569|M.thermoresistible__bu YASAAAELSSVLANVQAGSWEGPSAERYVAAHAPYLAWLTQQSANSAATA
MAV_2429|M.avium_104 YAAAAAELDGLLAAAHAGAWEGPSAEQYVAAHAPYQAWLLESAAKSSTAA
MLBr_01828|M.leprae_Br4923 YAEMADELVALLVVVPVSSWDGSAAEAYVIAYLPYLGWLRQASVDSAVMA
MAB_0669|M.abscessus_ATCC_1997 YANTAVELAQVLAGVRAGSWQGPSASEYVAAHLPYLAWLEQAAAESSVIA
Mb3047c|M.bovis_AF2122/97 YAAVAQELSAVVAAVGAGVWQGPSAELFVAAYVPYVAWLVQASADSAAAA
Rv3018c|M.tuberculosis_H37Rv YAAVAQELSVVVAAVGAGVWQGPSAELFVAAYVPYVAWLVQASADSAAAA
MUL_2932|M.ulcerans_Agy99 FEATAAEVDHQICEAIR-LWQGRAADDYVAAHTPYVVWLDHAAIVCQRAG
MMAR_2806|M.marinum_M FEATAAEVDHQICEAIR-LWQGRAADDYVAAHTPYVVWLDHAAIVCQRAG
: * *: : . *:* ::. :* *: ** ** . : .
Mflv_0325|M.gilvum_PYR-GCK VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE
Mvan_0415|M.vanbaalenii_PYR-1 AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE
MSMEG_0619|M.smegmatis_MC2_155 VQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNE
TH_3569|M.thermoresistible__bu GRHETAAAAYSTALATMPTMAELTLNKTTHAVLVATNFLGINTIPIALNE
MAV_2429|M.avium_104 SLHETAAGAYTAALAAMPTLGELATNHAVHGALVATNFFGINTIPIAVNE
MLBr_01828|M.leprae_Br4923 AHYETMATAYITTLAMMPTLAELAANRTAHTVLVTTNFFGINTIPIARNE
MAB_0669|M.abscessus_ATCC_1997 AQHETTAAAYNSALAAMPTLAELAANHITHGVLVGTNFFGINTIPIALNE
Mb3047c|M.bovis_AF2122/97 GEHEAAAAGYVCALAEMPTLPELAANHLTHAVLVATNFFGINTIPIALNE
Rv3018c|M.tuberculosis_H37Rv GEHEAAAAGYVCALAEMPTLPELAANHLTHAVLVATNFFGINTIPIALNE
MUL_2932|M.ulcerans_Agy99 AALQMMVAAYGDALAEMPTMAELQENHAVHGVLVATNFFGLNGVPIAVNE
MMAR_2806|M.marinum_M AALQMMVAAYSDALAEMPTMAELQENHAVHGVLVATNFFGLNGVPIAVNE
: . .* :** ***: ** *: * .** ***:*:* :*** .*
Mflv_0325|M.gilvum_PYR-GCK ADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLPGVGEAGRAAA
Mvan_0415|M.vanbaalenii_PYR-1 ADYVRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPGVGEAGRAAA
MSMEG_0619|M.smegmatis_MC2_155 ADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPGVGEAGSASA
TH_3569|M.thermoresistible__bu ADYVRMWIQAATSMSTYQAVAGTAVMSAPASSPAPLLLAPGVSEAADAMA
MAV_2429|M.avium_104 ADYARMWVQAATTMSTYQAVSQSALAAVPPTTPAPTIVAPGT-EAGTATA
MLBr_01828|M.leprae_Br4923 IDYVRMWVEAAIAMGTYQEVSTVVVDSAPEAIAAPQIMASDALEASSDQP
MAB_0669|M.abscessus_ATCC_1997 ADYVRMWVQAAATMSAYQATTEAMTSAIPPTQQPPAILSPGGEARSDQSD
Mb3047c|M.bovis_AF2122/97 ADYVRMWVQAATVMSAYEAVVGAALVATPHTGPAPVIVKPGANEASNAVA
Rv3018c|M.tuberculosis_H37Rv ADYVRMWVQAATVMSAYEAVVGAALVATPHTGPAPVIVKPGANEASNAVA
MUL_2932|M.ulcerans_Agy99 ADYVRMWIQAAGVMGVYESCTSAALLEVRPTCPSPVLVNPGVEGVGNATS
MMAR_2806|M.marinum_M ADYVRMWIQAAGVMGVYESCTSAALLEVPPTSPSPVLVNPGVEGVGNATS
**.***::** *..*: : .* :: .. .
Mflv_0325|M.gilvum_PYR-GCK DMSAFAAQPMAAQA--------GAAFDVSNIIADIIRLY--GEVLR---F
Mvan_0415|M.vanbaalenii_PYR-1 DVTAFAAQAQAAEA--------GSALDLSNIIADLIRAY--GELLR---F
MSMEG_0619|M.smegmatis_MC2_155 SVQQMSAQATAAES--------GSSLDLSSIISDLLNQY--LQGVP---G
TH_3569|M.thermoresistible__bu TTQQIGSQATAADS--------GTALNLSDLIANLLQYY--QDYLD---Q
MAV_2429|M.avium_104 AAVQSAAAAPATDS--------GSNLNHADTSSTQQQASTAAQSYP---S
MLBr_01828|M.leprae_Br4923 SPTAPSQSP-QVQNWLQWLQKIGYTDFYNTLVQPLITSLTNHPFFQGMFS
MAB_0669|M.abscessus_ATCC_1997 VPGSPDQIMKMLQGFQQWFEKMGFNPATSAVLAVIMLFLYDLLWYP----
Mb3047c|M.bovis_AF2122/97 AATIT-------------------PFPFGELAKFLEMAAQAFTEVG----
Rv3018c|M.tuberculosis_H37Rv AATIT-------------------PFPWHEIVQFLEETFAAYDQYL----
MUL_2932|M.ulcerans_Agy99 WSGFADSDEFSVSS---------FNDGVLGLDVAVAGELCEFDPFDG---
MMAR_2806|M.marinum_M WSGFADSDEFSVSS---------FNDGVLGLD--VAGELCEFDPFDG---
Mflv_0325|M.gilvum_PYR-GCK LFEPIFNFLRDPIGNTFALITDFLTN------PVQALITWGPFLLAVVYQ
Mvan_0415|M.vanbaalenii_PYR-1 LFEPIFDFLRDPLGNTIKLITDFLTN------PAQALITWGPFLAAVAYQ
MSMEG_0619|M.smegmatis_MC2_155 GQ-AILDFLKDPLGNLGRLLTDFMTN------PAGALATWWPFLFGVAYQ
TH_3569|M.thermoresistible__bu LFGPIVDFLRDPIGNLFQLIDDFLTN------PAGALVTWWPLLFAVAYQ
MAV_2429|M.avium_104 WQDQLTAWLKQYTQNFAWPVSKDLNPGGWPFPPVPFVNGLASFFGQLGFS
MLBr_01828|M.leprae_Br4923 GFDPWLPSLGNPLSFLSPFNIAFALGTPMDIGSYVGYLSQTFAFIGADLA
MAB_0669|M.abscessus_ATCC_1997 ----------YYASYLLPFLIPALSG----LSGLAALMHLRPAAPGPVPA
Mb3047c|M.bovis_AF2122/97 ------ELIMKSAEAWAVGFVELITG----------LVNFEPWLVLTGMI
Rv3018c|M.tuberculosis_H37Rv ------SALLSELPAVAWVWFQLFVD----------ILGFNIIGFIITLA
MUL_2932|M.ulcerans_Agy99 ----------LDLDGCQLVSVSTTQG------------------FGAAMD
MMAR_2806|M.marinum_M ----------LDLDGCQLVSVSTTQG------------------FGAAMD
Mflv_0325|M.gilvum_PYR-GCK -AVSWVGA------------SILYPSLFLLPLLATTLAIVAGVGQHLLSL
Mvan_0415|M.vanbaalenii_PYR-1 -AVSWVGA------------SILYPSLLLLPLVATTLAIVLGVGAYLLEN
MSMEG_0619|M.smegmatis_MC2_155 -VFFNLVG------------WPTWGMIFASPFLIPALAALGITGLVLLID
TH_3569|M.thermoresistible__bu -VFTNLVG------------WPTWAMILASPVLIPLAITLGVAGLVMIAD
MAV_2429|M.avium_104 PALSTALG------------WAIFHTLMIFWPFMQAAIQMAVVLAPVVVA
MLBr_01828|M.leprae_Br4923 AAFASGNPVTIGFTLLFTTIEAIGTIITDTIALVKTMIEQSFVLLPMILP
MAB_0669|M.abscessus_ATCC_1997 AALSPGD---------------------RPIRRPTQHVEPNLAALP----
Mb3047c|M.bovis_AF2122/97 DMFFATVG------------FALGVFVLVPLLEFAVVLELAILSIGWIIS
Rv3018c|M.tuberculosis_H37Rv SNAQLLTE------------FAINASYVAVGLLYAIAGVIDIV-VEWVIG
MUL_2932|M.ulcerans_Agy99 VTAAPGSPLSG--------AALAPTGHICAGVPLATSTPLGVT-------
MMAR_2806|M.marinum_M VTAAPGSPLSG--------AALAPTGHICAGVPLATSTPLGVT-------
Mflv_0325|M.gilvum_PYR-GCK LNTP-PAEEAAEEPAPAQSAPSRPDQQSFPATMSAPPPPSGAPIAANTVS
Mvan_0415|M.vanbaalenii_PYR-1 LPAP-AEDAPAEEPAASSPAPTRADQPSPAIAVSAPPPPSSAAATVGTVA
MSMEG_0619|M.smegmatis_MC2_155 HVLNNPVDVPAEDEAPQEVAAAPRTDQPLAVGISPAGVPGSAATAAAPAP
TH_3569|M.thermoresistible__bu QAQP-----PAEEAAPEEDVAAP-------------------VRAEPQNP
MAV_2429|M.avium_104 AIGAAAAGGAAAAVTAISVAAPLSMAAPVPVAAAPAPVATVPAPTIAGAP
MLBr_01828|M.leprae_Br4923 LLTAPLAVATAGAAGSFAGLSELAGLVGVAPPGLPSAPPVAAVAPVVPPS
MAB_0669|M.abscessus_ATCC_1997 ---------------------------------LPTSSVVPSGGSSVPVS
Mb3047c|M.bovis_AF2122/97 NIFG--------------------------------------AIPVLAGP
Rv3018c|M.tuberculosis_H37Rv NLFG--------------------------------------VVPLLGGP
MUL_2932|M.ulcerans_Agy99 --------------------------------------------------
MMAR_2806|M.marinum_M --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK AGS---PPAPGAPAAAAATFVPYVVAGRDPYEGFSPTVRD----------
Mvan_0415|M.vanbaalenii_PYR-1 TGT---APAPGAPAAATASFVPYAVAGRDPGTGFSPTVRD----------
MSMEG_0619|M.smegmatis_MC2_155 APA---GTTVAAPAPAAATFVPYAVANRDPGEGFTPTLGN----------
TH_3569|M.thermoresistible__bu LPL---TXXX----------------------------------------
MAV_2429|M.avium_104 AGVSHVPTTASAPAPTMAGSAGGGPVGGGPGVGFGPTATDGIGAGMSDAL
MLBr_01828|M.leprae_Br4923 MPTLASIPTPTPMPAPAASTAPVVTPPGPPPVTAPPSVTG----------
MAB_0669|M.abscessus_ATCC_1997 TPT-APAHTVSSVPAPSAAISYAIPGLVPPGVSFGPKSTE----------
Mb3047c|M.bovis_AF2122/97 LLG----ALAAAVVPGVAGVTGLAGLAAVPAVGAAAGAPA----------
Rv3018c|M.tuberculosis_H37Rv LLG----ALAAAVVPGVAGLAGVAGLAALPAVGAAAGAPA----------
MUL_2932|M.ulcerans_Agy99 -------RHVGDLQMMAARDNSDRAVVDAPHEILVSDSRG----------
MMAR_2806|M.marinum_M -------RHVGDLQMMAARDNSDRTVVDAPHEILVSDSRG----------
Mflv_0325|M.gilvum_PYR-GCK --------------------STGAKAPAGTIPAAASGIAASAAERRKRRR
Mvan_0415|M.vanbaalenii_PYR-1 --------------------STSAKAPASGIPAAASGVAASAAERRKRRR
MSMEG_0619|M.smegmatis_MC2_155 --------------------KSQVAAPASGVPAAASGVAASLASRRKRRR
TH_3569|M.thermoresistible__bu --------------------------------------------------
MAV_2429|M.avium_104 YAVGLSGLSARGSASSRARRKSEEPAPDDLDAPAAAAAAAAGSKKARARR
MLBr_01828|M.leprae_Br4923 ------------------AGVESFGYLVGRLPSTARGVVGTSVRQQSSAP
MAB_0669|M.abscessus_ATCC_1997 ------------------KSSESAVDTVAAV-AAARGAVAAQARRRLRGK
Mb3047c|M.bovis_AF2122/97 -------------------------ALVGSVAPVSGGVVSPQARLVSAVE
Rv3018c|M.tuberculosis_H37Rv -------------------------ALVGSVAPVSGGVVSPQARLVSAVE
MUL_2932|M.ulcerans_Agy99 ----------------------------GTAQSGASGSVRPGVGSASVVQ
MMAR_2806|M.marinum_M ----------------------------GTAQSGASGSVRPGVGSASVVQ
Mflv_0325|M.gilvum_PYR-GCK RQKEEIKGRGYADAYA-------DYEELPDDGPPEQPAPRVTASTRGAGP
Mvan_0415|M.vanbaalenii_PYR-1 RQKDEIAGRAYADAYA-------DYEPEPDDEPPVRQEPRIAATERGAGP
MSMEG_0619|M.smegmatis_MC2_155 KKGAQIEERGYADAYM-------DYEE-PDEDPAPQPEPRVRASERGSDA
TH_3569|M.thermoresistible__bu --------------------------------------------------
MAV_2429|M.avium_104 RRRGTATDRAYRYEYM-------DLDTDSGPEDG-GPDDGPVASEASAGQ
MLBr_01828|M.leprae_Br4923 DRIEAPDAAATPQEQARSRWRRRAKVTPFDSSGSPNPKAAPTASDQGAGT
MAB_0669|M.abscessus_ATCC_1997 NKAEAGGRRHEYLEET-------AGMGATATADVP----AYAATGRGTGP
Mb3047c|M.bovis_AF2122/97 PAPASTSVS-------------------------------VLASDRGAGA
Rv3018c|M.tuberculosis_H37Rv PAPASTSVS-------------------------------VLASDRGAGA
MUL_2932|M.ulcerans_Agy99 AASPGRPVS-------------------------------ELAGGRGAGT
MMAR_2806|M.marinum_M AASDGRPVS-------------------------------ELAGGRGAGT
Mflv_0325|M.gilvum_PYR-GCK MGFAGTVSRGDEQ-AGGLTTLAGDSFGGGPREPMLPGTWDPDATDDRHTD
Mvan_0415|M.vanbaalenii_PYR-1 MGFAGTVSRDAAQ-AGGLTTLPGDPFGGGPKAPMLPGTWDPDTEPD----
MSMEG_0619|M.smegmatis_MC2_155 MGFTGTVTRHDVT-AAGLTTLTGDTFDDRPVTPMLPGTWDGDENPA----
TH_3569|M.thermoresistible__bu --------------------------------------------------
MAV_2429|M.avium_104 LGFAGAATKSDAARPAGLATLTRDGSSEGPGVPMMPSTWDRD--------
MLBr_01828|M.leprae_Br4923 LGLAGTARQASSGPATGLVTLSNGTFSDSPRAPMLPRTWGADPTFCYNAA
MAB_0669|M.abscessus_ATCC_1997 LGFAGTAPAAASTHVAATVRLSSD--EARQVIPMLPSTWDAD--------
Mb3047c|M.bovis_AF2122/97 LGFVGTAGKESVGQPAGLTVLADEFGDGAP-VPMLPGSWGPDLVG-----
Rv3018c|M.tuberculosis_H37Rv LGFVGTAGKESVGQPAGLTVLADEFGDGAP-VPMLPGSWGPDLVG-----
MUL_2932|M.ulcerans_Agy99 VGFAGVSATGTKVRPAGLSATGGGEFGSGAGVPVLPATWPLQVVGS----
MMAR_2806|M.marinum_M VGFAGVSATGTKVRPAGLSATGGGEFGSGAGVPVLPATWPLQVVGS----
Mflv_0325|M.gilvum_PYR-GCK GRDGHDGHDGKEKP--
Mvan_0415|M.vanbaalenii_PYR-1 --ERHNHHDGKDSQ--
MSMEG_0619|M.smegmatis_MC2_155 --PSPDDPEGGPRR--
TH_3569|M.thermoresistible__bu ----------------
MAV_2429|M.avium_104 ----------------
MLBr_01828|M.leprae_Br4923 DIGPAGGWDDE-----
MAB_0669|M.abscessus_ATCC_1997 ------GGDQN-----
Mb3047c|M.bovis_AF2122/97 -----VAGDGGLVSV-
Rv3018c|M.tuberculosis_H37Rv -----VAGDGGLVSV-
MUL_2932|M.ulcerans_Agy99 -----TSGSGVSPPAL
MMAR_2806|M.marinum_M -----TSGSGVSPPAL