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TRLVGQRILVTGAGSGIGQATVLRLLDEGATVVGADIDAAGLSRTQARTAEAGTGARLTTCQIDVADEKS VVDGVGAAVQALGGLDALVNAAGMLRAAHTHQTSIQQWNQIIAVNLTGTFLVVREALPALLDNQRSTVVN FSSTSAAFAHPYMAAYAASKGGVQAFTHSLALEYARDGLRAVCVAPGSIKSGITDATGGYIPADANWSLF TRLMPILPTTETSSGAGMADPSVVAGVIAMLVSEDGAFITGTEIRIDGGTHA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_4967 | - | - | 100% (263) | short-chain type dehydrogenase/reductase |
| M. marinum M | MMAR_3470 | - | 2e-31 | 34.38% (256) | short chain membrane-associated dehydrogenase |
| M. marinum M | MMAR_2869 | - | 1e-29 | 32.22% (270) | short-chain type dehydrogenase/reductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1976 | - | 6e-34 | 33.33% (264) | short-chain type dehydrogenase/reductase |
| M. gilvum PYR-GCK | Mflv_4541 | - | 9e-74 | 55.06% (267) | short-chain dehydrogenase/reductase SDR |
| M. tuberculosis H37Rv | Rv1941 | - | 6e-34 | 33.33% (264) | short-chain type dehydrogenase/reductase |
| M. leprae Br4923 | MLBr_01740 | - | 4e-21 | 32.82% (195) | short chain dehydrogenase |
| M. abscessus ATCC 19977 | MAB_0296 | - | 3e-26 | 32.14% (252) | putative 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase |
| M. avium 104 | MAV_0672 | - | 1e-116 | 79.85% (263) | oxidoreductase |
| M. smegmatis MC2 155 | MSMEG_2852 | - | 1e-77 | 58.21% (268) | 3-oxoacyl- |
| M. thermoresistible (build 8) | TH_2959 | - | 2e-76 | 57.84% (268) | PUTATIVE short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_4041 | - | 1e-144 | 99.62% (263) | short-chain type dehydrogenase/reductase |
| M. vanbaalenii PYR-1 | Mvan_2848 | - | 5e-77 | 56.51% (269) | short-chain dehydrogenase/reductase SDR |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1976|M.bovis_AF2122/97 ---------MNHPDLAGKVAIVTGAGAGIGLAVARRLADEGCHVLCADID
Rv1941|M.tuberculosis_H37Rv ---------MNHPDLAGKVAIVTGAGAGIGLAVARRLADEGCHVLCADID
MMAR_4967|M.marinum_M -----------MTRLVGQRILVTGAGSGIGQATVLRLLDEGATVVGADID
MUL_4041|M.ulcerans_Agy99 -----------MTRLVGQRILVTGAGSGIGQATVLRLLDEGATVVGADID
MAV_0672|M.avium_104 -----------MKRLEGKRILVTGAASGIGQATALRLLDEGAAVAASDVA
Mflv_4541|M.gilvum_PYR-GCK ------------MRYSGRRVLITGGGSGIGQACALRILAEGGRVAAADIS
Mvan_2848|M.vanbaalenii_PYR-1 MSATPTGSSPQLTRYAGRRVLITGGGSGIGQACVLRILAEGGRVVAADIS
MSMEG_2852|M.smegmatis_MC2_155 MPDLQAESPIAPSRYAGRRVLITGGGSGIGQACVLRILAEGAQVVAADIS
TH_2959|M.thermoresistible__bu -------VSDLSARYAARRVLITGGGSGIGQACVLRILAEGGRVAAADIS
MAB_0296|M.abscessus_ATCC_1997 -----------------MVAVVTGAGGGVGSRVVTTLARRHERVVAVDID
MLBr_01740|M.leprae_Br4923 -------MVKTAQYFVGKRCFVTGAASGIGRATALRLAAYGAELYLTDRH
.:**...*:* . : : *
Mb1976|M.bovis_AF2122/97 GDAADAAATKIGCGAA-----ACRVDVSDEQQIIAMVDACVAAFGGVDKL
Rv1941|M.tuberculosis_H37Rv GDAADAAATKIGCGAA-----ACRVDVSDEQQIIAMVDACVAAFGGVDKL
MMAR_4967|M.marinum_M AAGLSRTQARTAEAGTGARLTTCQIDVADEKSVVDGVGAAVQALGGLDAL
MUL_4041|M.ulcerans_Agy99 ADGLSRTQARTAEAGTGARLTTCQIDVADEKSVVDGVGAAVQALGGLDAL
MAV_0672|M.avium_104 VDGLERTRDRAAQAGTAERLVTVTMDVGREDAVVDGVRVAVEQLGGLDSL
Mflv_4541|M.gilvum_PYR-GCK GDGLADTVQKAGDLAT--NLMTVVMDVGDEPSVSSGVAEAIAALGGLDTL
Mvan_2848|M.vanbaalenii_PYR-1 ADGLADTAEKAGALGT--GLSTVVMDVGDEQSVSAGLAEALNTLGGLDTL
MSMEG_2852|M.smegmatis_MC2_155 PEGLDDTTGKAGEFSS--RLTTVTLDVGDEDSVRAGVAAAVAELGGLDTL
TH_2959|M.thermoresistible__bu PSGLRDTVNQAGAAAE--RLTTVTMDVADEQSVRHGVGQAITALGGLDAL
MAB_0296|M.abscessus_ATCC_1997 EVAIKQLVEYAADEGLD--VIGQILDITDDTAVAVGVSDIESRVGPITAL
MLBr_01740|M.leprae_Br4923 CDGLAQTVSEARALGAQ-VPEYRALDISDYDEVAAFGADIHARHPSMDIV
. . :*: : : :
Mb1976|M.bovis_AF2122/97 VANAGVVHLASLIDTTVEDFDRVIAINLRGAWLCTKHAAPRMIER-GGGA
Rv1941|M.tuberculosis_H37Rv VANAGVVHLASLIDTTVEDFDRVIAINLRGAWLCTKHAAPRMIER-GGGA
MMAR_4967|M.marinum_M VNAAGMLRAAHTHQTSIQQWNQIIAVNLTGTFLVVREALPALLDN-QRST
MUL_4041|M.ulcerans_Agy99 VNAAGMLRAAHTHQTSIQQWNQIIAVNLTGTFLVVREALPALLDN-QRST
MAV_0672|M.avium_104 VNAAGMLRAAHTHQTSLQLWNQIIGVNLTGTFLVVREALPALLDN-ARSA
Mflv_4541|M.gilvum_PYR-GCK VNAAGILRSAHLADTTLADFEQVLRINLIGTFLVTRESLAALRDG-RGPA
Mvan_2848|M.vanbaalenii_PYR-1 VNAAGILRSAHLAQTTLADFEQVLRINLIGTFLVTREAVTALHQG-DGSA
MSMEG_2852|M.smegmatis_MC2_155 VNAAGILRSSHLAQTSLADFEQVLRINLTGTFLVTREAIGALLEG-HRPA
TH_2959|M.thermoresistible__bu VNAAGILRSAHLVQTTLADFEQVIRINLTGTFLVTRECIPALLDG-NGPA
MAB_0296|M.abscessus_ATCC_1997 VNGAGVLRTGAAVEFSDADWARTFDVNVRAPFVLSREVARRMIPR-RAGS
MLBr_01740|M.leprae_Br4923 MNIAGVSVWGTVDRLTHDQWSNVVAINLMGPIHIIETFVPAILAAGRGGH
: **: . : : . . :*: .. . :
Mb1976|M.bovis_AF2122/97 IVNLSSLAGQVAVGGTGAYGMSKAGIIQLSRITAAELRSSGIRSNTLLPA
Rv1941|M.tuberculosis_H37Rv IVNLSSLAGQVAVGGTGAYGMSKAGIIQLSRITAAELRSSGIRSNTLLPA
MMAR_4967|M.marinum_M VVNFSSTSAAFAHPYMAAYAASKGGVQAFTHSLALEYARDGLRAVCVAPG
MUL_4041|M.ulcerans_Agy99 VVNFSSTSAAFAHPYMAAYAASKGGVQAFTHSLALEYARDGLRAVCVAPG
MAV_0672|M.avium_104 VVNFSSTSASFAHPYMAAYAASKGGIQAFTHSLALEYARRGLRAVCVAPG
Mflv_4541|M.gilvum_PYR-GCK VVNFSSTSAHFAHPYMAAYAASKGGVLAMTHAWALEFAKAGIRFNCVQPG
Mvan_2848|M.vanbaalenii_PYR-1 VVNFSSTSAQFAHPYMAAYAASKGGVLAMTHAWALEFAKAGIRFNCVQPG
MSMEG_2852|M.smegmatis_MC2_155 VVNFSSTSAHFAHPYMAAYAASKGGVLAMTHAWALEFAKAGIRFNSVQPG
TH_2959|M.thermoresistible__bu VVNFSSTSAHFAHPYMAAYAASKGGVLAMTHTWAAEFAKAGIRFNAVQPG
MAB_0296|M.abscessus_ATCC_1997 VVTVASNAALVARKGMTAYAASKAAANAFTKSLGLELAEYGIRCNVVAPG
MLBr_01740|M.leprae_Br4923 LVNVSSAAGLVALPWHAAYSASKYGLRGLSEVLRFDLARYRIGVSVVVPG
:*..:* :. .* **. ** . ::. : : : *.
Mb1976|M.bovis_AF2122/97 FVDTPMQQTAMAM---------------FDG---ALGAGGARSMIARLQ-
Rv1941|M.tuberculosis_H37Rv FVDTPMQQTAMAM---------------FDG---ALGAGGARSMIARLQ-
MMAR_4967|M.marinum_M SIKSGITDATGG----------------------YIPADANWSLFTRLMP
MUL_4041|M.ulcerans_Agy99 SIKSGITDATGG----------------------YIPADANWSLFTRLMP
MAV_0672|M.avium_104 SIKSGITDATGG----------------------YIPEDADWSLFSRLLP
Mflv_4541|M.gilvum_PYR-GCK SISSGMTDGTGAS---------------RQSVGPGLPEDADYALFGKVAP
Mvan_2848|M.vanbaalenii_PYR-1 SISSGMTDGTGAS---------------RQSIGPGLPEDADYTLFAKVAP
MSMEG_2852|M.smegmatis_MC2_155 SISSGMTDGTGAS---------------RQSIGPGLPEDADFSLFGKVAP
TH_2959|M.thermoresistible__bu SISSGMTDGSGVS---------------RQSVGPGLPEDADLALFAKVAP
MAB_0296|M.abscessus_ATCC_1997 STDTPMLRAMLGD---------------------SSDAGLVAGSLGDYKP
MLBr_01740|M.leprae_Br4923 AVRTPLVDTIEIAGVDRQDPRFSRWVDRFRGHAVSAERAAEKILAGVAKN
: :
Mb1976|M.bovis_AF2122/97 ----------GRMAAPEEMAGIVVFLLSDDASMITGTTQIADGGTIAALW
Rv1941|M.tuberculosis_H37Rv ----------GRMAAPEEMAGIVVFLLSDDASMITGTTQIADGGTIAALW
MMAR_4967|M.marinum_M ILPTTETSSGAGMADPSVVAGVIAMLVSEDGAFITGTEIRIDGGTHA---
MUL_4041|M.ulcerans_Agy99 ILPTTETSSGAGMADPSVVAGVIAMLVSEDGAFITGTEIRIDGGTHA---
MAV_0672|M.avium_104 VLPTTVESSGTGMAEPTAVAGVIAMLVSDDGAFITGTEIRIDGGTHA---
Mflv_4541|M.gilvum_PYR-GCK MLP---LDDGAIFAAPDAVAGVVAMLGSSDAYFITGTEVRIDGGSHM---
Mvan_2848|M.vanbaalenii_PYR-1 MLP---LDGGAIFAAPDAVAGVVAMLGSRDAYFITGTEVRIDGGSHM---
MSMEG_2852|M.smegmatis_MC2_155 MLP---LDGGAIFARPDAVAGVVAMLGSADAYFITGTEVRIDGGSHM---
TH_2959|M.thermoresistible__bu ALP---LGDGTIFADPDAVAGVVAMLGSDDAFFITGTEVRIDGGAHM---
MAB_0296|M.abscessus_ATCC_1997 GIP------LGRVAQPQHIADAVAFLLSDQAAHITMHTLVVDGGATLGV-
MLBr_01740|M.leprae_Br4923 RYLIYTSHDIRVLYGFKRLAWWPYGVVMKQVNVVFTRALRPSPATMRCVE
. :* : : : . .:
Mb1976|M.bovis_AF2122/97 --------------------
Rv1941|M.tuberculosis_H37Rv --------------------
MMAR_4967|M.marinum_M --------------------
MUL_4041|M.ulcerans_Agy99 --------------------
MAV_0672|M.avium_104 --------------------
Mflv_4541|M.gilvum_PYR-GCK --------------------
Mvan_2848|M.vanbaalenii_PYR-1 --------------------
MSMEG_2852|M.smegmatis_MC2_155 --------------------
TH_2959|M.thermoresistible__bu --------------------
MAB_0296|M.abscessus_ATCC_1997 --------------------
MLBr_01740|M.leprae_Br4923 PIKVGVYSQPRSGEGGKSGN