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MRYSGRRVLITGGGSGIGQACALRILAEGGRVAAADISGDGLADTVQKAGDLATNLMTVVMDVGDEPSVS SGVAEAIAALGGLDTLVNAAGILRSAHLADTTLADFEQVLRINLIGTFLVTRESLAALRDGRGPAVVNFS STSAHFAHPYMAAYAASKGGVLAMTHAWALEFAKAGIRFNCVQPGSISSGMTDGTGASRQSVGPGLPEDA DYALFGKVAPMLPLDDGAIFAAPDAVAGVVAMLGSSDAYFITGTEVRIDGGSHM
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4541 | - | - | 100% (264) | short-chain dehydrogenase/reductase SDR |
| M. gilvum PYR-GCK | Mflv_4104 | - | 7e-34 | 35.91% (259) | short-chain dehydrogenase/reductase SDR |
| M. gilvum PYR-GCK | Mflv_4369 | fabG | 4e-31 | 32.57% (261) | 3-ketoacyl-(acyl-carrier-protein) reductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1976 | - | 3e-33 | 35.00% (260) | short-chain type dehydrogenase/reductase |
| M. tuberculosis H37Rv | Rv1941 | - | 3e-33 | 35.00% (260) | short-chain type dehydrogenase/reductase |
| M. leprae Br4923 | MLBr_01740 | - | 2e-20 | 32.12% (193) | short chain dehydrogenase |
| M. abscessus ATCC 19977 | MAB_4680c | - | 1e-28 | 33.72% (258) | putative short-chain dehydrogenase/reductase |
| M. marinum M | MMAR_4967 | - | 1e-73 | 55.06% (267) | short-chain type dehydrogenase/reductase |
| M. avium 104 | MAV_0672 | - | 1e-76 | 56.93% (267) | oxidoreductase |
| M. smegmatis MC2 155 | MSMEG_2852 | - | 1e-124 | 84.03% (263) | 3-oxoacyl- |
| M. thermoresistible (build 8) | TH_2959 | - | 1e-120 | 82.89% (263) | PUTATIVE short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_4041 | - | 9e-75 | 55.43% (267) | short-chain type dehydrogenase/reductase |
| M. vanbaalenii PYR-1 | Mvan_2848 | - | 1e-129 | 88.59% (263) | short-chain dehydrogenase/reductase SDR |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1976|M.bovis_AF2122/97 ---------MNHPDLAGKVAIVTGAGAGIGLAVARRLADEGCHVLCADID
Rv1941|M.tuberculosis_H37Rv ---------MNHPDLAGKVAIVTGAGAGIGLAVARRLADEGCHVLCADID
Mflv_4541|M.gilvum_PYR-GCK ------------MRYSGRRVLITGGGSGIGQACALRILAEGGRVAAADIS
Mvan_2848|M.vanbaalenii_PYR-1 MSATPTGSSPQLTRYAGRRVLITGGGSGIGQACVLRILAEGGRVVAADIS
MSMEG_2852|M.smegmatis_MC2_155 MPDLQAESPIAPSRYAGRRVLITGGGSGIGQACVLRILAEGAQVVAADIS
TH_2959|M.thermoresistible__bu -------VSDLSARYAARRVLITGGGSGIGQACVLRILAEGGRVAAADIS
MMAR_4967|M.marinum_M -----------MTRLVGQRILVTGAGSGIGQATVLRLLDEGATVVGADID
MUL_4041|M.ulcerans_Agy99 -----------MTRLVGQRILVTGAGSGIGQATVLRLLDEGATVVGADID
MAV_0672|M.avium_104 -----------MKRLEGKRILVTGAASGIGQATALRLLDEGAAVAASDVA
MAB_4680c|M.abscessus_ATCC_199 -------MNGNSALLQGKNVIVTGGARGLGAAFSRHIVSQGGRVVIADVL
MLBr_01740|M.leprae_Br4923 -------MVKTAQYFVGKRCFVTGAASGIGRATALRLAAYGAELYLTDRH
.: ::**.. *:* * :: * : :*
Mb1976|M.bovis_AF2122/97 GDAADAAATKIGCGAA-----ACRVDVSDEQQIIAMVDACVAAFGGVDKL
Rv1941|M.tuberculosis_H37Rv GDAADAAATKIGCGAA-----ACRVDVSDEQQIIAMVDACVAAFGGVDKL
Mflv_4541|M.gilvum_PYR-GCK GDGLADTVQKAGDLAT--NLMTVVMDVGDEPSVSSGVAEAIAALGGLDTL
Mvan_2848|M.vanbaalenii_PYR-1 ADGLADTAEKAGALGT--GLSTVVMDVGDEQSVSAGLAEALNTLGGLDTL
MSMEG_2852|M.smegmatis_MC2_155 PEGLDDTTGKAGEFSS--RLTTVTLDVGDEDSVRAGVAAAVAELGGLDTL
TH_2959|M.thermoresistible__bu PSGLRDTVNQAGAAAE--RLTTVTMDVADEQSVRHGVGQAITALGGLDAL
MMAR_4967|M.marinum_M AAGLSRTQARTAEAGTGARLTTCQIDVADEKSVVDGVGAAVQALGGLDAL
MUL_4041|M.ulcerans_Agy99 ADGLSRTQARTAEAGTGARLTTCQIDVADEKSVVDGVGAAVQALGGLDAL
MAV_0672|M.avium_104 VDGLERTRDRAAQAGTAERLVTVTMDVGREDAVVDGVRVAVEQLGGLDSL
MAB_4680c|M.abscessus_ATCC_199 DGDGRQLAAELGDAAR-----FTHLDVTDAEQWRELIDTTLAGFGTITGL
MLBr_01740|M.leprae_Br4923 CDGLAQTVSEARALGAQ-VPEYRALDISDYDEVAAFGADIHARHPSMDIV
. . :*: : :
Mb1976|M.bovis_AF2122/97 VANAGVVHLASLIDTTVEDFDRVIAINLRGAWLCTKHAAPRMIERG-GGA
Rv1941|M.tuberculosis_H37Rv VANAGVVHLASLIDTTVEDFDRVIAINLRGAWLCTKHAAPRMIERG-GGA
Mflv_4541|M.gilvum_PYR-GCK VNAAGILRSAHLADTTLADFEQVLRINLIGTFLVTRESLAALRDGR-GPA
Mvan_2848|M.vanbaalenii_PYR-1 VNAAGILRSAHLAQTTLADFEQVLRINLIGTFLVTREAVTALHQGD-GSA
MSMEG_2852|M.smegmatis_MC2_155 VNAAGILRSSHLAQTSLADFEQVLRINLTGTFLVTREAIGALLEGH-RPA
TH_2959|M.thermoresistible__bu VNAAGILRSAHLVQTTLADFEQVIRINLTGTFLVTRECIPALLDGN-GPA
MMAR_4967|M.marinum_M VNAAGMLRAAHTHQTSIQQWNQIIAVNLTGTFLVVREALPALLDNQ-RST
MUL_4041|M.ulcerans_Agy99 VNAAGMLRAAHTHQTSIQQWNQIIAVNLTGTFLVVREALPALLDNQ-RST
MAV_0672|M.avium_104 VNAAGMLRAAHTHQTSLQLWNQIIGVNLTGTFLVVREALPALLDNA-RSA
MAB_4680c|M.abscessus_ATCC_199 VNNAGISSAAMVADEPLEHFRKVIEINLVGVFIGMQAVIPAMRAHG-CGS
MLBr_01740|M.leprae_Br4923 MNIAGVSVWGTVDRLTHDQWSNVVAINLMGPIHIIETFVPAILAAGRGGH
: **: . . : .:: :** * . :
Mb1976|M.bovis_AF2122/97 IVNLSSLAGQVAVGGTGAYGMSKAGIIQLSRITAAELRSSGIRSNTLLPA
Rv1941|M.tuberculosis_H37Rv IVNLSSLAGQVAVGGTGAYGMSKAGIIQLSRITAAELRSSGIRSNTLLPA
Mflv_4541|M.gilvum_PYR-GCK VVNFSSTSAHFAHPYMAAYAASKGGVLAMTHAWALEFAKAGIRFNCVQPG
Mvan_2848|M.vanbaalenii_PYR-1 VVNFSSTSAQFAHPYMAAYAASKGGVLAMTHAWALEFAKAGIRFNCVQPG
MSMEG_2852|M.smegmatis_MC2_155 VVNFSSTSAHFAHPYMAAYAASKGGVLAMTHAWALEFAKAGIRFNSVQPG
TH_2959|M.thermoresistible__bu VVNFSSTSAHFAHPYMAAYAASKGGVLAMTHTWAAEFAKAGIRFNAVQPG
MMAR_4967|M.marinum_M VVNFSSTSAAFAHPYMAAYAASKGGVQAFTHSLALEYARDGLRAVCVAPG
MUL_4041|M.ulcerans_Agy99 VVNFSSTSAAFAHPYMAAYAASKGGVQAFTHSLALEYARDGLRAVCVAPG
MAV_0672|M.avium_104 VVNFSSTSASFAHPYMAAYAASKGGIQAFTHSLALEYARRGLRAVCVAPG
MAB_4680c|M.abscessus_ATCC_199 IVNISSAAGLVGLALTSGYGASKWGVRGLSKVAAIELGRERIRVNSVHPG
MLBr_01740|M.leprae_Br4923 LVNVSSAAGLVALPWHAAYSASKYGLRGLSEVLRFDLARYRIGVSVVVPG
:**.** :. .. ..*. ** *: ::. : : : *.
Mb1976|M.bovis_AF2122/97 FVDTPMQQTAMAMFDG---ALGAGGARSMIARLQ-----------GRMAA
Rv1941|M.tuberculosis_H37Rv FVDTPMQQTAMAMFDG---ALGAGGARSMIARLQ-----------GRMAA
Mflv_4541|M.gilvum_PYR-GCK SISSGMTDGTGASRQSVGPGLPEDADYALFGKVAPMLP---LDDGAIFAA
Mvan_2848|M.vanbaalenii_PYR-1 SISSGMTDGTGASRQSIGPGLPEDADYTLFAKVAPMLP---LDGGAIFAA
MSMEG_2852|M.smegmatis_MC2_155 SISSGMTDGTGASRQSIGPGLPEDADFSLFGKVAPMLP---LDGGAIFAR
TH_2959|M.thermoresistible__bu SISSGMTDGSGVSRQSVGPGLPEDADLALFAKVAPALP---LGDGTIFAD
MMAR_4967|M.marinum_M SIKSGITDATGG-------YIPADANWSLFTRLMPILPTTETSSGAGMAD
MUL_4041|M.ulcerans_Agy99 SIKSGITDATGG-------YIPADANWSLFTRLMPILPTTETSSGAGMAD
MAV_0672|M.avium_104 SIKSGITDATGG-------YIPEDADWSLFSRLLPVLPTTVESSGTGMAE
MAB_4680c|M.abscessus_ATCC_199 VIYTPMTAKEGFR---------EGEGNMPIAAMG------------RVGN
MLBr_01740|M.leprae_Br4923 AVRTPLVDTIEIAG--------VDRQDPRFSRWVDRFR------GHAVSA
: : : . : ..
Mb1976|M.bovis_AF2122/97 PEEMAGIVVFLLSDDASMITGTTQIADGGTIAALW---------------
Rv1941|M.tuberculosis_H37Rv PEEMAGIVVFLLSDDASMITGTTQIADGGTIAALW---------------
Mflv_4541|M.gilvum_PYR-GCK PDAVAGVVAMLGSSDAYFITGTEVRIDGGSHM------------------
Mvan_2848|M.vanbaalenii_PYR-1 PDAVAGVVAMLGSRDAYFITGTEVRIDGGSHM------------------
MSMEG_2852|M.smegmatis_MC2_155 PDAVAGVVAMLGSADAYFITGTEVRIDGGSHM------------------
TH_2959|M.thermoresistible__bu PDAVAGVVAMLGSDDAFFITGTEVRIDGGAHM------------------
MMAR_4967|M.marinum_M PSVVAGVIAMLVSEDGAFITGTEIRIDGGTHA------------------
MUL_4041|M.ulcerans_Agy99 PSVVAGVIAMLVSEDGAFITGTEIRIDGGTHA------------------
MAV_0672|M.avium_104 PTAVAGVIAMLVSDDGAFITGTEIRIDGGTHA------------------
MAB_4680c|M.abscessus_ATCC_199 ADEVAGAVAYLLSDAASYVTGAELAVDGGWTAGPTLTTITGQ--------
MLBr_01740|M.leprae_Br4923 ERAAEKILAGVAKNRYLIYTSHDIRVLYGFKRLAWWPYGVVMKQVNVVFT
:. : . *. *
Mb1976|M.bovis_AF2122/97 ----------------------------------
Rv1941|M.tuberculosis_H37Rv ----------------------------------
Mflv_4541|M.gilvum_PYR-GCK ----------------------------------
Mvan_2848|M.vanbaalenii_PYR-1 ----------------------------------
MSMEG_2852|M.smegmatis_MC2_155 ----------------------------------
TH_2959|M.thermoresistible__bu ----------------------------------
MMAR_4967|M.marinum_M ----------------------------------
MUL_4041|M.ulcerans_Agy99 ----------------------------------
MAV_0672|M.avium_104 ----------------------------------
MAB_4680c|M.abscessus_ATCC_199 ----------------------------------
MLBr_01740|M.leprae_Br4923 RALRPSPATMRCVEPIKVGVYSQPRSGEGGKSGN