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TAIMWMASPPEVHSGLLSSGPGAGPMLASAAAWKSLSGEYASAAAELAGLVGAVPQVWWGPAEQSYAAAN ERYLAWLTQVSADYARQAALVDVVVAAYGAAVAAMPSLVELAANHTVHAVLSATNFFGVNTIPIAVNEMD YVRMWVQAAAVMGTYQMITQGELLAAPNIAPAPWILVPGGEAAAVVGPAASAAAATPPLAALIALIVAAI ETPSIATVLAALVAIVAFPVQAVVFFFSTLLGQFFSWIPVISLSYAQIIIGYFVGFLAAAPVLTSGAEIA VPVSVPLGVGRHLYDVQMANADLAEVERVAERSREVLVSAHHAIAPQPLSDSVSTVASVDVPAVAPSDQG AGPWGFVSTASKGIVAQPSGLTTLAGAEVGDGPAMPMLPATWGPALATVAG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_4914 | - | - | 100% (402) | PPE family protein |
| M. marinum M | MMAR_3006 | - | 1e-77 | 42.09% (411) | PPE family protein |
| M. marinum M | MMAR_3005 | - | 5e-72 | 42.96% (412) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3047c | PPE47 | 7e-71 | 41.99% (443) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0325 | - | 1e-59 | 40.00% (375) | PPE protein |
| M. tuberculosis H37Rv | Rv3018c | PPE46 | 2e-70 | 42.18% (441) | PPE family protein |
| M. leprae Br4923 | MLBr_01828 | PPE | 1e-50 | 40.85% (284) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_0047 | - | 3e-59 | 39.19% (370) | PPE family protein |
| M. avium 104 | MAV_4867 | - | 3e-62 | 41.69% (391) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 5e-58 | 55.67% (203) | PPE family protein |
| M. thermoresistible (build 8) | TH_3569 | - | 5e-57 | 42.76% (304) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_0492 | - | 0.0 | 99.00% (402) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 2e-63 | 42.08% (385) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_4914|M.marinum_M ----------MT---AIMWMASPPEVHSGLLSSGPGAGPMLASAAAWKSL
MUL_0492|M.ulcerans_Agy99 ----------MT---AIMWMASPPEVHSGLLSSGPGAGPMLASAAAWKSL
Mb3047c|M.bovis_AF2122/97 ----------MT---APVWLASPPEVHSALLSAGPGPGSLQAAAAGWSAL
Rv3018c|M.tuberculosis_H37Rv ----------MT---APVWLASPPEVHSALLSAGPGPGSLQAAAAGWSAL
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVT---SPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSL
Mvan_0415|M.vanbaalenii_PYR-1 ----------MS---SPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSL
MSMEG_0619|M.smegmatis_MC2_155 ----------MT---APIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSL
TH_3569|M.thermoresistible__bu ---------MMT---APIWMALPPEVHSALLSSGPGPGSLLAAASAWHAL
MAB_0047|M.abscessus_ATCC_1997 ----------MS---APIWMASPPEVHSALLSAGPGPGALLAAAAQWQAL
MAV_4867|M.avium_104 ----------MTSPFGPIWMASPPEVHSALLSAGPGPGPLLAAAGAWTSL
MLBr_01828|M.leprae_Br4923 ----------MS---APIWMASPPEVHSALLSRGPGSGPLLVAAEAWRSL
:: . :*:* ****** :** ***.*.: .:. * :*
MMAR_4914|M.marinum_M SGEYASAAAELAGLVGAVPQ-VWWGPAEQSYAAANERYLAWLTQVSADYA
MUL_0492|M.ulcerans_Agy99 SGEYASAAAELAGLVGAVPQ-VWWGPAEQSYAAANERYLAWLTQVSADYA
Mb3047c|M.bovis_AF2122/97 SAEYAAVAQELSAVVAAVGAGVWQGPSAELFVAAYVPYVAWLVQASADSA
Rv3018c|M.tuberculosis_H37Rv SAEYAAVAQELSVVVAAVGAGVWQGPSAELFVAAYVPYVAWLVQASADSA
Mflv_0325|M.gilvum_PYR-GCK SAEYASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSA
Mvan_0415|M.vanbaalenii_PYR-1 SAEYAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGA
MSMEG_0619|M.smegmatis_MC2_155 SAEYAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSA
TH_3569|M.thermoresistible__bu SAEYASAAAELSSVLANVQAGSWEGPSAERYVAAHAPYLAWLTQQSANSA
MAB_0047|M.abscessus_ATCC_1997 STQYATAATELTELLGSTVAGSWQGPSAMQYAASHAPYLAWLTQQSAMSA
MAV_4867|M.avium_104 SAQYATAAAELSALLGEAQAGSWEGESAAQYAAAHLPYLAWLQQASADSA
MLBr_01828|M.leprae_Br4923 SSVYAEMADELVALLVVVPVSSWDGSAAEAYVIAYLPYLGWLRQASVDSA
* ** * ** :: . * * : :. : *: ** * *. *
MMAR_4914|M.marinum_M RQAALVDVVVAAYGAAVAAMPSLVELAANHTVHAVLSATNFFGVNTIPIA
MUL_0492|M.ulcerans_Agy99 RQATLVDVVVAAYGAAVAAMPSLVELAANHTVHAVLSATNFFGVNTIPIA
Mb3047c|M.bovis_AF2122/97 AAAGEHEAAAAGYVCALAEMPTLPELAANHLTHAVLVATNFFGINTIPIA
Rv3018c|M.tuberculosis_H37Rv AAAGEHEAAAAGYVCALAEMPTLPELAANHLTHAVLVATNFFGINTIPIA
Mflv_0325|M.gilvum_PYR-GCK ATAVQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIA
Mvan_0415|M.vanbaalenii_PYR-1 AAAAQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIA
MSMEG_0619|M.smegmatis_MC2_155 AAAVQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIA
TH_3569|M.thermoresistible__bu ATAGRHETAAAAYSTALATMPTMAELTLNKTTHAVLVATNFLGINTIPIA
MAB_0047|M.abscessus_ATCC_1997 TNAVLHETSAAAYTTALAAMPTLAELAANHMIHGVLLATNFFGINTIPIA
MAV_4867|M.avium_104 GAAAQQEVAATAYTTALAAMPTLAELAANHTIHGVLLATNFFGINTIPIA
MLBr_01828|M.leprae_Br4923 VMAAHYETMATAYITTLAMMPTLAELAANRTAHTVLVTTNFFGINTIPIA
* :. .:.* ::* **:: **: *: * ** ***:*:******
MMAR_4914|M.marinum_M VNEMDYVRMWVQAAAVMGTYQMITQGELLAAPNIAPAPWILVPGGEAAA-
MUL_0492|M.ulcerans_Agy99 VNEMDYVRMWVQAAAVMGTYQMITQGELLAAPNIAPAPWILVLGGEAAA-
Mb3047c|M.bovis_AF2122/97 LNEADYVRMWVQAATVMSAYEAVVGAALVATPHTGPAPVIVKPGANEAS-
Rv3018c|M.tuberculosis_H37Rv LNEADYVRMWVQAATVMSAYEAVVGAALVATPHTGPAPVIVKPGANEAS-
Mflv_0325|M.gilvum_PYR-GCK LNEADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLPGVGEAGR
Mvan_0415|M.vanbaalenii_PYR-1 MTEADYVRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPGVGEAGR
MSMEG_0619|M.smegmatis_MC2_155 LNEADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPGVGEAGS
TH_3569|M.thermoresistible__bu LNEADYVRMWIQAATSMSTYQAVAGTAVMSAPASSPAPLLLAPGVSEAAD
MAB_0047|M.abscessus_ATCC_1997 LNEADYIRMWIQAATTMGVYQGVSSAALAATTPTQPSPMIMAPG-GEMSR
MAV_4867|M.avium_104 VNEADYARMWVQAATTMGTYQAVAGSALAAAPRTAPAPSIVKPG-GEAN-
MLBr_01828|M.leprae_Br4923 RNEIDYVRMWVEAAIAMGTYQEVSTVVVDSAPEAIAAPQIMASDALEASS
.* ** ***::** *..*: : : ::. .:* :: .
MMAR_4914|M.marinum_M --------VVGPAAS------AAAATPPLAALIALI--------------
MUL_0492|M.ulcerans_Agy99 --------VVGLAAS------AAAATPPLAALIALI--------------
Mb3047c|M.bovis_AF2122/97 ----------NAVAA------ATITPFPFGELAK----------------
Rv3018c|M.tuberculosis_H37Rv ----------NAVAA------ATITPFPWHEIVQ----------------
Mflv_0325|M.gilvum_PYR-GCK AAADMSAFAAQPMAA------QAGAAFDVSNIIADIIRLYGEVLRFLF--
Mvan_0415|M.vanbaalenii_PYR-1 AAADVTAFAAQAQAA------EAGSALDLSNIIADLIRAYGELLRFLF--
MSMEG_0619|M.smegmatis_MC2_155 ASASVQQMSAQATAA------ESGSSLDLSSIISDLLNQYLQGVPGGQ--
TH_3569|M.thermoresistible__bu AMATTQQIGSQATAA------DSGTALNLSDLIANLLQYYQDYLDQLF--
MAB_0047|M.abscessus_ATCC_1997 MSADMMSMAAQPQAA------ESGSALDSSNNIMDQLMR-----------
MAV_4867|M.avium_104 ------NLAANAAQN------SSG---DWWQNFIQQLSQ-----------
MLBr_01828|M.leprae_Br4923 DQPSPTAPSQSPQVQNWLQWLQKIGYTDFYNTLVQPLITSLTNHPFFQGM
MMAR_4914|M.marinum_M -------------VAAIETPS-----------IATVLAALVAIVAFPVQA
MUL_0492|M.ulcerans_Agy99 -------------VAAIETPS-----------IATVLAALVAIVAFPVQA
Mb3047c|M.bovis_AF2122/97 -------------FLEMAAQA-----------FTEVGELIMKSAEAWAVG
Rv3018c|M.tuberculosis_H37Rv -------------FLEETFAA-----------YDQYLSALLSELPAVAWV
Mflv_0325|M.gilvum_PYR-GCK EPIFNFLRDPIGNTFALITDF-----------LTNPVQALITWGPFLLAV
Mvan_0415|M.vanbaalenii_PYR-1 EPIFDFLRDPLGNTIKLITDF-----------LTNPAQALITWGPFLAAV
MSMEG_0619|M.smegmatis_MC2_155 -AILDFLKDPLGNLGRLLTDF-----------MTNPAGALATWWPFLFGV
TH_3569|M.thermoresistible__bu GPIVDFLRDPIGNLFQLIDDF-----------LTNPAGALVTWWPLLFAV
MAB_0047|M.abscessus_ATCC_1997 -----FMTNPLGTLQDMIEDF-----------MRNPVAAFFAWFPLLFFI
MAV_4867|M.avium_104 -----FFQN----IQKMLQDF-----------WANLPAFLAANGPLLFFV
MLBr_01828|M.leprae_Br4923 FSGFDPWLPSLGNPLSFLSPFNIAFALGTPMDIGSYVGYLSQTFAFIGAD
:
MMAR_4914|M.marinum_M VVFFFST----LLGQFFSWIPVISL-------------------SYAQII
MUL_0492|M.ulcerans_Agy99 VVFFFST----LLGQFFSWIPVISL-------------------SYAQII
Mb3047c|M.bovis_AF2122/97 FVELITG----LVNFEPWLVLTGMI-------------------DMFFAT
Rv3018c|M.tuberculosis_H37Rv WFQLFVD----ILGFNIIGFIITLA-------------------SNAQLL
Mflv_0325|M.gilvum_PYR-GCK VYQAVSW----VGASILYPSLFLLP-------------------LLATTL
Mvan_0415|M.vanbaalenii_PYR-1 AYQAVSW----VGASILYPSLLLLP-------------------LVATTL
MSMEG_0619|M.smegmatis_MC2_155 AYQVFFN----LVGWPTWGMIFASP-------------------FLIPAL
TH_3569|M.thermoresistible__bu AYQVFTN----LVGWPTWAMILASP-------------------VLIPLA
MAB_0047|M.abscessus_ATCC_1997 AYEAFFI----PFGFTFWGVLLSAP-------------------AWLPIV
MAV_4867|M.avium_104 AYQVFFN----AVGWPTWGAILTAP-------------------FLLPLL
MLBr_01828|M.leprae_Br4923 LAAAFASGNPVTIGFTLLFTTIEAIGTIITDTIALVKTMIEQSFVLLPMI
.
MMAR_4914|M.marinum_M IGYFVGFLAAAPVLTSG---------------------------------
MUL_0492|M.ulcerans_Agy99 IGYFVGFLAAAPVLTSG---------------------------------
Mb3047c|M.bovis_AF2122/97 VGFALGVFVLVPLLEFA-----------VVLELAILSIGWIISNIFGAIP
Rv3018c|M.tuberculosis_H37Rv TEFAINASYVAVGLLYA-----------IAGVIDIV-VEWVIGNLFGVVP
Mflv_0325|M.gilvum_PYR-GCK AIVAGVGQHLLSLLNTP-PAEEAAEEPAPAQSAPSRPDQQSFPATMSAPP
Mvan_0415|M.vanbaalenii_PYR-1 AIVLGVGAYLLENLPAP-AEDAPAEEPAASSPAPTRADQPSPAIAVSAPP
MSMEG_0619|M.smegmatis_MC2_155 AALGITGLVLLIDHVLNNPVDVPAEDEAPQEVAAAPRTDQPLAVGISPAG
TH_3569|M.thermoresistible__bu ITLGVAGLVMIADQAQP-----PAEEAAPEEDVAAP--------------
MAB_0047|M.abscessus_ATCC_1997 LGLALSALVPPAGIEEPGQEDEPGREPTRIE-RRSPQQDLQLAHVPSGSP
MAV_4867|M.avium_104 LGIGLSSLLAAPAEIAP-VAAPAAITPVLAS-NKPPTLPAAVALAPS-VA
MLBr_01828|M.leprae_Br4923 LPLLTAPLAVATAGAAG-SFAGLSELAGLVGVAPPGLPSAPPVAAVAPVV
MMAR_4914|M.marinum_M -------AEIAVPV--SVPLGVGRHLYDVQMANADLAEVERVAERSREVL
MUL_0492|M.ulcerans_Agy99 -------AEIAVPV--SVPLGVGRHLYDVQMANADVAEVERVAERSREVL
Mb3047c|M.bovis_AF2122/97 VLAGPLLGALAAAV--VPGVAGVTGLAGLAAVPAVGAAAGAPAALVGSVA
Rv3018c|M.tuberculosis_H37Rv LLGGPLLGALAAAV--VPGVAGLAGVAGLAALPAVGAAAGAPAALVGSVA
Mflv_0325|M.gilvum_PYR-GCK PPSGAPIAANTVSA--GSPPAPGAPAAAAATFVPYVVAGRDPYEGFSPTV
Mvan_0415|M.vanbaalenii_PYR-1 PPSSAAATVGTVAT--GTAPAPGAPAAATASFVPYAVAGRDPGTGFSPTV
MSMEG_0619|M.smegmatis_MC2_155 VPGSAATAAAPAPA--PAGTTVAAPAPAAATFVPYAVANRDPGEGFTPTL
TH_3569|M.thermoresistible__bu -----VRAEPQNPL--PLTXXX----------------------------
MAB_0047|M.abscessus_ATCC_1997 TPGGSTTTTVTSGG--SAPPAP-APATATPAYMVYAVQEDPPAARFGPTL
MAV_4867|M.avium_104 TPAGAPASTVAAGS--GAAAAP-GPAAAAGNFAYLVAFGGDPDTGVGPTL
MLBr_01828|M.leprae_Br4923 PPSMPTLASIPTPTPMPAPAASTAPVVTPPGPPPVTAPPSVTGAGVESFG
MMAR_4914|M.marinum_M VSAHHAIAPQPLSDSVSTVASVDVPA------------------------
MUL_0492|M.ulcerans_Agy99 VSAHHAIAPQPLSDSVSTVASVDVPA------------------------
Mb3047c|M.bovis_AF2122/97 PVSGGVVSPQARLVSAVEPAPASTSVS-----------------------
Rv3018c|M.tuberculosis_H37Rv PVSGGVVSPQARLVSAVEPAPASTSVS-----------------------
Mflv_0325|M.gilvum_PYR-GCK RDSTGAKAPAGTIPAAASGIAASAAERRKRRRRQKEEIKGRGYADAYADY
Mvan_0415|M.vanbaalenii_PYR-1 RDSTSAKAPASGIPAAASGVAASAAERRKRRRRQKDEIAGRAYADAYADY
MSMEG_0619|M.smegmatis_MC2_155 GNKSQVAAPASGVPAAASGVAASLASRRKRRRKKGAQIEERGYADAYMDY
TH_3569|M.thermoresistible__bu --------------------------------------------------
MAB_0047|M.abscessus_ATCC_1997 NEGSGAKAPAAGISAAAAAAAS-ARSRARRKRAARIKDPAPQFMDMNSSV
MAV_4867|M.avium_104 SGRGGAKAPAATIPAAGAAAPARAEARARRRRRAALHDYSDEFLDMDSGF
MLBr_01828|M.leprae_Br4923 YLVGRLPSTARGVVGTSVRQQSSAPDRIEAPDAAATPQEQARSRWRRRAK
MMAR_4914|M.marinum_M ---------------VAPSDQGAGPWGFVSTASKGI-VAQPSGLTTLAG-
MUL_0492|M.ulcerans_Agy99 ---------------VAPSDQGAGPWGFVSTASKGI-VAQPSGLTTLAG-
Mb3047c|M.bovis_AF2122/97 ---------------VLASDRGAGALGFVGTAGKES-VGQPAGLTVLAD-
Rv3018c|M.tuberculosis_H37Rv ---------------VLASDRGAGALGFVGTAGKES-VGQPAGLTVLAD-
Mflv_0325|M.gilvum_PYR-GCK EELPDDGPPEQPAPRVTASTRGAGPMGFAGTVSRGD--EQAGGLTTLAG-
Mvan_0415|M.vanbaalenii_PYR-1 EPEPDDEPPVRQEPRIAATERGAGPMGFAGTVSRDA--AQAGGLTTLPG-
MSMEG_0619|M.smegmatis_MC2_155 EE-PDEDPAPQPEPRVRASERGSDAMGFTGTVTRHD--VTAAGLTTLTG-
TH_3569|M.thermoresistible__bu --------------------------------------------------
MAB_0047|M.abscessus_ATCC_1997 APDFSES-AARQTTGVGASARGAGRLGFAGTAPAAAGTTAAAGLVERDSG
MAV_4867|M.avium_104 GVPPDYG-AEEELAAAVASGQGAGTLGFAGTQQRRK-AFQAAGLTKLAD-
MLBr_01828|M.leprae_Br4923 VTPFDSSGSPNPKAAPTASDQGAGTLGLAGTARQAS-SGPATGLVTLSN-
MMAR_4914|M.marinum_M --AEVGDGPAMPMLPATWGPALATV------------AG----
MUL_0492|M.ulcerans_Agy99 --AEVGDGPAMPMLPATWGPALATV------------AG----
Mb3047c|M.bovis_AF2122/97 ---EFGDGAPVPMLPGSWGPDLVGV---------AGDGGLVSV
Rv3018c|M.tuberculosis_H37Rv ---EFGDGAPVPMLPGSWGPDLVGV---------AGDGGLVSV
Mflv_0325|M.gilvum_PYR-GCK --DSFGGGPREPMLPGTWDPDATDDRHTDGRDGHDGHDGKEKP
Mvan_0415|M.vanbaalenii_PYR-1 --DPFGGGPKAPMLPGTWDPDTEPD------ERHNHHDGKDSQ
MSMEG_0619|M.smegmatis_MC2_155 --DTFDDRPVTPMLPGTWDGDENPA------PSPDDPEGGPRR
TH_3569|M.thermoresistible__bu -------------------------------------------
MAB_0047|M.abscessus_ATCC_1997 TAEALDGARTVPMLPTSWGTDSEHGP------DRPAEGGSST-
MAV_4867|M.avium_104 --DDFGGSPRMPMVPGTWEQDTQNG-------AHPTEPGKGG-
MLBr_01828|M.leprae_Br4923 --GTFSDSPRAPMLPRTWGADPTFCYN---AADIGPAGGWDDE