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MTHAIRPVDFDNLKTMTYEVTDRVARITFNRPEKGNAIVADTPLELSALVERADLDPAVHVILVSGRGEG FCAGFDLSAYAEGSSSSGAEGGYRGTVLDGKAQAVNHLPNQPWDPMIDYQMMSRFVRGFSSLMHADKPTV VKIHGYCVAGGTDIALHADQVIAAADAKIGYPPTRVWGVPAAGLWAHRLGDQRAKRLLFTGDCITGAQAA EWGLAVEAPDPKDLDERTERLVERIAALPVNQLIMIKLALNSALLQQGVVNSRMLSTVFDGVARHTPEGH AFVADAVEHGFRDAVKHRDEPFGDYGRRASSV
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_1002 | echA4 | - | 100% (312) | enoyl-CoA hydratase, EchA4 |
| M. marinum M | MMAR_0778 | echA2 | 8e-45 | 35.23% (298) | enoyl-CoA hydratase EchA2 |
| M. marinum M | MMAR_4020 | echA4_2 | 5e-23 | 28.67% (286) | enoyl-CoA hydratase, EchA4_2 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0692 | echA4 | 1e-171 | 92.63% (312) | enoyl-CoA hydratase |
| M. gilvum PYR-GCK | Mflv_4357 | - | 8e-22 | 29.37% (286) | enoyl-CoA hydratase/isomerase |
| M. tuberculosis H37Rv | Rv0673 | echA4 | 1e-171 | 92.63% (312) | enoyl-CoA hydratase |
| M. leprae Br4923 | MLBr_02402 | - | 7e-15 | 24.12% (257) | enoyl-CoA hydratase |
| M. abscessus ATCC 19977 | MAB_3859c | - | 1e-141 | 76.82% (302) | enoyl-CoA hydratase |
| M. avium 104 | MAV_4499 | - | 1e-169 | 91.67% (312) | enoyl-CoA hydratase |
| M. smegmatis MC2 155 | MSMEG_1388 | - | 1e-162 | 88.46% (312) | enoyl-CoA hydratase |
| M. thermoresistible (build 8) | TH_2027 | echA13 | 7e-23 | 30.16% (252) | POSSIBLE ENOYL-CoA HYDRATASE ECHA13 (ENOYL HYDRASE) |
| M. ulcerans Agy99 | MUL_0754 | echA4 | 1e-179 | 98.72% (312) | enoyl-CoA hydratase |
| M. vanbaalenii PYR-1 | Mvan_1270 | - | 1e-151 | 85.43% (302) | enoyl-CoA hydratase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_1002|M.marinum_M MTHAIRPVDFDNLKTMTYEVTDRVARITFNRPEKGNAIVADTPLELSALV
MUL_0754|M.ulcerans_Agy99 MTHAIRPVDFDNLKTMTYEVTDRVARITFNRPEKGNAIVADTPLELSALV
Mb0692|M.bovis_AF2122/97 MTHAIRPVDFDNLKTMTYEVTGRIARITFNRPEKGNAIIADTPLELSALV
Rv0673|M.tuberculosis_H37Rv MTHAIRPVDFDNLKTMTYEVTGRIARITFNRPEKGNAIIADTPLELSALV
MAV_4499|M.avium_104 MTHAIRPVDFDNLKTMTYEVTDRVARITFNRPEKGNAIVADTPLELSALV
MSMEG_1388|M.smegmatis_MC2_155 MTHAIRPVDFDNLKTMTYEVTDRVARITFNRPEKGNAIVADTPLELSALV
Mvan_1270|M.vanbaalenii_PYR-1 MT--------ETLKTMTYEVTGRVARITFNRPETGNAIIADTPLELAALV
MAB_3859c|M.abscessus_ATCC_199 --------MVDTLKTMTYEVTDRVARITFNRPEQGNAIIADTPLELAALV
Mflv_4357|M.gilvum_PYR-GCK -----MTTTDDDRVLFDVDRDTRIATITLNNPKQRNSYDAAMRNLLARHL
MLBr_02402|M.leprae_Br4923 ----------MKYDTILVDGYQRVGIITLNRPQALNALNSQMMNEITNAA
TH_2027|M.thermoresistible__bu MQMTERTGAEYSYVTYEVLDEGRIARIMMNRPRQRNAQNRGLLVELDDAF
*:. * :*.*. *: :
MMAR_1002|M.marinum_M ERADLDPAVHVILVSGRGEGFCAGFDLSAYAEGSSSSGAEGGYRGTVLDG
MUL_0754|M.ulcerans_Agy99 ERADLDPAVQVILVSGRGEGFCAGFDLSAYAEGSSSSGAEGGYRGTVLDG
Mb0692|M.bovis_AF2122/97 ERADLDPGVHVILVSGRGEGFCAGFDLSAYAEGSSSTGGGGAYQGTVLDG
Rv0673|M.tuberculosis_H37Rv ERADLDPGVHVILVSGRGEGFCAGFDLSAYAEGSSSTGGGGAYQGTVLDG
MAV_4499|M.avium_104 ERADLDPNVHVILVSGRGAGFCAGFDLSAYADRTGSAGGTGAYAGTVLDG
MSMEG_1388|M.smegmatis_MC2_155 ERADLDPDVHVILVSGRGEGFCAGFDLSAYAEGSSSAGGGSPYEGTVLSG
Mvan_1270|M.vanbaalenii_PYR-1 ERADLDPSVHVILVSGRGEGFCAGFDLGAYAEGSSTAGTDR--RGTVLDG
MAB_3859c|M.abscessus_ATCC_199 ERADLDPQVHVILVSGRGDGFCGGFDLSAYAEANDE--GSVRYSGTALDG
Mflv_4357|M.gilvum_PYR-GCK DEVAEDDDITVVLLRGAEGVFSTGADMNN---------AYGWYGPEDPAG
MLBr_02402|M.leprae_Br4923 KELDIDPDVGAILITGSPKVFAAGADIKEMAS------------------
TH_2027|M.thermoresistible__bu MRAERDDDVRVVILGGIGPMFSSGHDLGSSDD--------RAERSGGPAG
. * : .::: * *. * *:
MMAR_1002|M.marinum_M KAQAVNHLPNQPWDPMIDYQMMSRFVRGFSSLMHADKPTVVKIHGYCVAG
MUL_0754|M.ulcerans_Agy99 KAQAVNHLPNQPWDPMIDYQMMSRFVRGFSSLTHADKPTVVKIHGYCVAG
Mb0692|M.bovis_AF2122/97 KTQAVNHLPNQPWDPMIDYQMMSRFVRGFASLMHADKPTVVKIHGYCVAG
Rv0673|M.tuberculosis_H37Rv KTQAVNHLPNQPWDPMIDYQMMSRFVRGFASLMHADKPTVVKIHGYCVAG
MAV_4499|M.avium_104 KTQAVNHLPDQPWDPMIDYQMMSRFVRGFSSLMHADKPTVVKIHGYCVAG
MSMEG_1388|M.smegmatis_MC2_155 KTQALNHLPDEPWDPMVDYQMMSRFVRGFASLMHCDKPTVVKIHGYCVAG
Mvan_1270|M.vanbaalenii_PYR-1 KTQAINHRADQPWDPMIDYQMMSRFVRGFSSLMRCDKPTVVKIHGYCVAG
MAB_3859c|M.abscessus_ATCC_199 QVQLRNHLPNINWDPMLDYQMMSRFTRGFSSLLHANKPTVVKVHGYCVAG
Mflv_4357|M.gilvum_PYR-GCK AGKPRKSRPSQRRRLTVDRKSFGFYHN----LMGFPKVTVGEISGYALGG
MLBr_02402|M.leprae_Br4923 --------------LTFTDAFDADFFSAWGKLAAVRTPMIAAVAGYALGG
TH_2027|M.thermoresistible__bu HPTYLFNGGSRQGTEQRMLQEWHYYFENARRWRNLKKITIAETHGPVLAA
: . : * :..
MMAR_1002|M.marinum_M GTDIALHADQVIAAADAKIGYPPTRVWG---VPAAGLWAH--RLGDQRAK
MUL_0754|M.ulcerans_Agy99 GTDIALHADQVIAAADAKIGYPPTRVWG---VPAAGLWAH--RLGDQRAK
Mb0692|M.bovis_AF2122/97 GTDIALHADQVIAAADAKIGYPPTRVWG---VPAAGLWAH--RLGDQRAK
Rv0673|M.tuberculosis_H37Rv GTDIALHADQVIAAADAKIGYPPTRVWG---VPAAGLWAH--RLGDQRAK
MAV_4499|M.avium_104 GTDIALHADQVIAAADAKIGYPPTRVWG---VPAAGLWAH--RLGDQRAK
MSMEG_1388|M.smegmatis_MC2_155 GTDIALHADQVIAAADAKIGYPPMRVWG---VPAAGLWAH--RLGDQRAK
Mvan_1270|M.vanbaalenii_PYR-1 GTDIALHADQVIAAADAKIGYPPTRVWG---VPAAGMWAH--RLGDQRAK
MAB_3859c|M.abscessus_ATCC_199 GTDIALHADQLIVAADAKIGYPPTRVWG---VPATGLWAH--KLGDQRAK
Mflv_4357|M.gilvum_PYR-GCK GFEMALMTDISVIARDTRIGMPATRFLGPA-LGSLHLFFH--RLGPVQAR
MLBr_02402|M.leprae_Br4923 GCELAMMCDLLIAADTAKFGQPEIKLGVLPGMGGSQRLTR--AIGKAKAM
TH_2027|M.thermoresistible__bu GLMIAWTCDLIVATPTTTFADVVGTRIG---MCGVEYFAHPWELGPRRAK
* :* * : : : :. : . : :* :*
MMAR_1002|M.marinum_M RLLFTGDCITGAQAAEWGLAVEAPDPKDLDERTERLVERIAALPVNQLIM
MUL_0754|M.ulcerans_Agy99 RLLFTGDCITGAQAAEWGLAVEAPDPKDLDERTERLVERIAALPVNQLIM
Mb0692|M.bovis_AF2122/97 RLLFTGDCITGAQAAEWGLAVEAPEPADLDERTERLVARIAALPVNQLIM
Rv0673|M.tuberculosis_H37Rv RLLFTGDCITGAQAAEWGLAVEAPEPADLDERTERLVARIAALPVNQLIM
MAV_4499|M.avium_104 RLLFTGDCITGAQAAEWGLAVEAPDPADLDERTERLVQRIAAVPVNQLIM
MSMEG_1388|M.smegmatis_MC2_155 RLLFTGDCITGAQAAEWGLAVEAPDPADLDARTERLVERIAAMPVNQLIM
Mvan_1270|M.vanbaalenii_PYR-1 RLLLTGDCLTGAQAAEWGLAVEAPDPADLDERTERLVERIAAVPVNQLIM
MAB_3859c|M.abscessus_ATCC_199 RLLLTGDCLSGRQAYDWGLAVEAPEPDELDERTERLVERIAAMPLNQLMM
Mflv_4357|M.gilvum_PYR-GCK RLLLTGDIIRAADVEHLGVFTETCDADAVTARARYWAEKAAKMPADGVVI
MLBr_02402|M.leprae_Br4923 DLILTGRTIDAAEAERSGLVSRVVLADDLLPEAKAVATTISQMSRSATRM
TH_2027|M.thermoresistible__bu ELLLTGDSLDAHTAHQWGMVSRIFPDDELQKRTMELAQRIAGLPTVTALL
*::** : . . *: . : .: . : :. :
MMAR_1002|M.marinum_M IKLALNSALLQQGVVNSRMLSTVFDGVAR---HTPEGHAFVADAVEHGFR
MUL_0754|M.ulcerans_Agy99 IKLALNSALLQQGGVNSRMLSTVFDGVAR---HTPEGHAFVADAVEHGFR
Mb0692|M.bovis_AF2122/97 VKLALNSALLQQGVATSRMVSTVFDGAAR---HTPEGHAFVADAVEHGFR
Rv0673|M.tuberculosis_H37Rv VKLALNSALLQQGVATSRMVSTVFDGAAR---HTPEGHAFVADAVEHGFR
MAV_4499|M.avium_104 VKLALNSALLQQGVATSRMVSTVFDGVAR---HTPEGHAFVADAVKHGFR
MSMEG_1388|M.smegmatis_MC2_155 AKLACNTALLNQGVATSQMVSTVFDGIAR---HTPEGHAFVATAREHGFR
Mvan_1270|M.vanbaalenii_PYR-1 VKLAMNSALYNQGVATSAMISTVFDGIAR---HTPEGHAFVAQAREHGFR
MAB_3859c|M.abscessus_ATCC_199 IKLACNSVLINQGIANSAMIGTVFDGISR---HTPEAHAFTADAIANGYR
Mflv_4357|M.gilvum_PYR-GCK AKEAFRLVEQSQAYQGEEVASYLFHAYGTNLQFADGEFNFVKTRAQHGTK
MLBr_02402|M.leprae_Br4923 AKEAVNRSFESTLAEGLLHERRLFH------------STFVTDDQSEGMA
TH_2027|M.thermoresistible__bu IKEAVNQSVDNMGFYNALNACFSLHQINH-----AHWAEVTGGESHLGTP
* * . . :. .. *
MMAR_1002|M.marinum_M DAVKHRDEPFGDYGRRASSV-
MUL_0754|M.ulcerans_Agy99 DAVNHRDEPFGDYGRRASSV-
Mb0692|M.bovis_AF2122/97 DAVRRRDEPFGDYGRQASRV-
Rv0673|M.tuberculosis_H37Rv DAVRRRDEPFGDYGRQASRV-
MAV_4499|M.avium_104 EAVRHRDEPFGDHGRQASQV-
MSMEG_1388|M.smegmatis_MC2_155 EAVRRRDEPMGDHGRRASDV-
Mvan_1270|M.vanbaalenii_PYR-1 EAVRGRDEPFGDYGRTTSGV-
MAB_3859c|M.abscessus_ATCC_199 QAVRHRDEPFGDYGRKPTEL-
Mflv_4357|M.gilvum_PYR-GCK EAFRLRDEHFHVPEP------
MLBr_02402|M.leprae_Br4923 AFIEKRAPQFTHR--------
TH_2027|M.thermoresistible__bu EFGVPRWQDAGPILPRPMSEA
*