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TSPVWMGSPPEVHSALLSSGPGAASLQVSASAWTSLGAAYSSAADELTAVVVVGETETWEGMGAASYAAA HQPYVAWLMRNGAEAEAMAAEHEAMAAAYCAALAAMPTMGELAENHLTHGVLLGTNFFGINTVPIAVNEA DYARMWVQAATAMSAYDAASTVFAARAPQTTPAPRLIRSLGDDAPNVLPQAANVLGSWSDFWEEFVYNFF DIFTYAWDSIALLGMDIGEYLGDPIGFLIAGVIGFFGGFAYGAVSDAVAGLLVAHSVSEAVAISLALASV LALDFAVTAMVLSAVAVPLAAAIAVPIALPIALPLGIDAYVRGSSDLGVGVADAGLRSVSASSLTQNIDT PTQLGGLAGVQSVPGPNDAVAGIDQDSVRHGLAGSVGVGDVQSWGFVGTSGSVRGEPSGLSMLGAESGGL RVPVLPSSWDLS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_4606 | - | - | 100% (433) | PPE family protein |
| M. marinum M | MMAR_5277 | - | 5e-69 | 38.24% (442) | PPE family protein |
| M. marinum M | MMAR_0787 | - | 2e-68 | 38.81% (438) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3043c | PPE46 | 3e-67 | 38.16% (435) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0325 | - | 3e-57 | 39.81% (314) | PPE protein |
| M. tuberculosis H37Rv | Rv3018c | PPE46 | 2e-67 | 37.99% (437) | PPE family protein |
| M. leprae Br4923 | MLBr_01828 | PPE | 8e-55 | 33.89% (419) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_4783 | - | 8e-60 | 38.26% (413) | PPE family protein |
| M. avium 104 | MAV_4867 | - | 1e-66 | 37.05% (475) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 3e-59 | 38.33% (360) | PPE family protein |
| M. thermoresistible (build 8) | TH_3569 | - | 8e-58 | 41.61% (310) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_4456 | - | 0.0 | 98.85% (433) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 1e-59 | 35.90% (429) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTS---PVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSL
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSS---PVWMALPPEVHSALLSSGPGPGSMLAAAATWQSL
MSMEG_0619|M.smegmatis_MC2_155 ----------MTA---PIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSL
TH_3569|M.thermoresistible__bu ---------MMTA---PIWMALPPEVHSALLSSGPGPGSLLAAASAWHAL
MAB_4783|M.abscessus_ATCC_1997 ----------MTA---PVWMAAPPEVHSALLSSGPGPGSLFAAADAWRSL
MAV_4867|M.avium_104 ----------MTSPFGPIWMASPPEVHSALLSAGPGPGPLLAAAGAWTSL
Mb3043c|M.bovis_AF2122/97 ----------MSSHRTPVWLASPPEVHSALLSAGPGPGSLQAAAAGWSAL
Rv3018c|M.tuberculosis_H37Rv -------------MTAPVWLASPPEVHSALLSAGPGPGSLQAAAAGWSAL
MLBr_01828|M.leprae_Br4923 ----------MSA---PIWMASPPEVHSALLSRGPGSGPLLVAAEAWRSL
MMAR_4606|M.marinum_M ----------MTS---PVWMGSPPEVHSALLSSGPGAASLQVSASAWTSL
MUL_4456|M.ulcerans_Agy99 ----------MTS---PVWMGSPPEVHSALLSSGPGAASLQVSASAWTSL
*:*:. ******::** ***...: .:. * :*
Mflv_0325|M.gilvum_PYR-GCK SAEYASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSA
Mvan_0415|M.vanbaalenii_PYR-1 SAEYAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGA
MSMEG_0619|M.smegmatis_MC2_155 SAEYAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSA
TH_3569|M.thermoresistible__bu SAEYASAAAELSSVLANVQAGSWEGPSAERYVAAHAPYLAWLTQQSANSA
MAB_4783|M.abscessus_ATCC_1997 STEYSSAANELTTTLGSVRAGVWDGASAEQYQTAHVPYLSWLHETSAVSA
MAV_4867|M.avium_104 SAQYATAAAELSALLGEAQAGSWEGESAAQYAAAHLPYLAWLQQASADSA
Mb3043c|M.bovis_AF2122/97 SAEYAAVAQELSAVVAAVGAGVWQGPSAELFVAAYVPYVAWLVQASADSA
Rv3018c|M.tuberculosis_H37Rv SAEYAAVAQELSVVVAAVGAGVWQGPSAELFVAAYVPYVAWLVQASADSA
MLBr_01828|M.leprae_Br4923 SSVYAEMADELVALLVVVPVSSWDGSAAEAYVIAYLPYLGWLRQASVDSA
MMAR_4606|M.marinum_M GAAYSSAADELTAVVVVGETETWEGMGAASYAAAHQPYVAWLMRNGAEAE
MUL_4456|M.ulcerans_Agy99 GAAYSSAADELTAVVVVGETETWEGMGAASYAAAHQPYVAWLMRNGAEAE
.: *: * ** : *:* .: : *: **: ** . .. .
Mflv_0325|M.gilvum_PYR-GCK ATAVQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIA
Mvan_0415|M.vanbaalenii_PYR-1 AAAAQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIA
MSMEG_0619|M.smegmatis_MC2_155 AAAVQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIA
TH_3569|M.thermoresistible__bu ATAGRHETAAAAYSTALATMPTMAELTLNKTTHAVLVATNFLGINTIPIA
MAB_4783|M.abscessus_ATCC_1997 GVAAQTETAATAYSEALATMPTLGELAANHATHGALVATNFFGINTIPIA
MAV_4867|M.avium_104 GAAAQQEVAATAYTTALAAMPTLAELAANHTIHGVLLATNFFGINTIPIA
Mb3043c|M.bovis_AF2122/97 AAAGEHEAAAAGYVCALAEMPTLPELAANHLTHAVLVATNFFGINTIPIA
Rv3018c|M.tuberculosis_H37Rv AAAGEHEAAAAGYVCALAEMPTLPELAANHLTHAVLVATNFFGINTIPIA
MLBr_01828|M.leprae_Br4923 VMAAHYETMATAYITTLAMMPTLAELAANRTAHTVLVTTNFFGINTIPIA
MMAR_4606|M.marinum_M AMAAEHEAMAAAYCAALAAMPTMGELAENHLTHGVLLGTNFFGINTVPIA
MUL_4456|M.ulcerans_Agy99 AMAAEHEAMAAAYCAALAAMPTMGELAENHLTHGVLLGTNFLGINTVPIA
* . :. *:.* :** ***: **: *: * .*: ***:****:***
Mflv_0325|M.gilvum_PYR-GCK LNEADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLPGVGEAGR
Mvan_0415|M.vanbaalenii_PYR-1 MTEADYVRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPGVGEAGR
MSMEG_0619|M.smegmatis_MC2_155 LNEADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPGVGEAGS
TH_3569|M.thermoresistible__bu LNEADYVRMWIQAATSMSTYQAVAGTAVMSAPASSPAPLLLAPGVSEAAD
MAB_4783|M.abscessus_ATCC_1997 VNEADYIRMWIQAATVMSTYQAVSESSVSAAPPTSPAPPVLSPDSGAAAR
MAV_4867|M.avium_104 VNEADYARMWVQAATTMGTYQAVAGSALAAAPRTAPAPSIVKPG-GEANN
Mb3043c|M.bovis_AF2122/97 LNEADYVRMWVQAATVMSAYEAVVGAALVATPHTGPAPVIVKPGANEASN
Rv3018c|M.tuberculosis_H37Rv LNEADYVRMWVQAATVMSAYEAVVGAALVATPHTGPAPVIVKPGANEASN
MLBr_01828|M.leprae_Br4923 RNEIDYVRMWVEAAIAMGTYQEVSTVVVDSAPEAIAAPQIMASDALEASS
MMAR_4606|M.marinum_M VNEADYARMWVQAATAMSAYDAASTVFAARAPQTTPAPRLIRSLGDDAPN
MUL_4456|M.ulcerans_Agy99 VNEADYERMWVQAATTMSAYDAASTVFAARAPQTTPAPRLIRSLGDDAPN
.* ** ***::** *.:*: . :* : .** :: . *
Mflv_0325|M.gilvum_PYR-GCK AAADMSAFAA--------------------QPMAAQAGAAFDVSNIIADI
Mvan_0415|M.vanbaalenii_PYR-1 AAADVTAFAA--------------------QAQAAEAGSALDLSNIIADL
MSMEG_0619|M.smegmatis_MC2_155 ASASVQQMSA--------------------QATAAESGSSLDLSSIISDL
TH_3569|M.thermoresistible__bu AMATTQQIGS--------------------QATAADSGTALNLSDLIANL
MAB_4783|M.abscessus_ATCC_1997 TAA---------------------------QDATKPPPIVPDPNDPIEML
MAV_4867|M.avium_104 LAAN-----------------------------AAQNSS----GDWWQNF
Mb3043c|M.bovis_AF2122/97 AVA----------------------------AATITPFPWHEIVQFLEET
Rv3018c|M.tuberculosis_H37Rv AVA----------------------------AATITPFPWHEIVQFLEET
MLBr_01828|M.leprae_Br4923 DQPSPTAPSQSPQVQNWLQWLQKIGYTDFYNTLVQPLITSLTNHPFFQGM
MMAR_4606|M.marinum_M VLP-------------------------------QAANVLGSWSDFWEEF
MUL_4456|M.ulcerans_Agy99 VLP-------------------------------QAANVLGSWSDFWEEF
.
Mflv_0325|M.gilvum_PYR-GCK IRLYGEVLRFLFEPIFNF--------------LRDPIGNTFALITDFLTN
Mvan_0415|M.vanbaalenii_PYR-1 IRAYGELLRFLFEPIFDF--------------LRDPLGNTIKLITDFLTN
MSMEG_0619|M.smegmatis_MC2_155 LNQYLQGVPGGQ-AILDF--------------LKDPLGNLGRLLTDFMTN
TH_3569|M.thermoresistible__bu LQYYQDYLDQLFGPIVDF--------------LRDPIGNLFQLIDDFLTN
MAB_4783|M.abscessus_ATCC_1997 LKNSQHFL-GMYRALKGL--------------ITDPVGTIVRIIIDFSTN
MAV_4867|M.avium_104 IQQLSQFF-----------------------------QNIQKMLQDFWAN
Mb3043c|M.bovis_AF2122/97 FAAYDQYLSALLSELPAV--------------AWVWFQLFVDILGFNIIG
Rv3018c|M.tuberculosis_H37Rv FAAYDQYLSALLSELPAV--------------AWVWFQLFVDILGFNIIG
MLBr_01828|M.leprae_Br4923 FSGFDPWLPSLGNPLSFLSPFNIAFALGTPMDIGSYVGYLSQTFAFIGAD
MMAR_4606|M.marinum_M VYNFFDIFTYAWDSIALLG----------------------MDIGEYLGD
MUL_4456|M.ulcerans_Agy99 VYNFFDIFTYAWDSIALLG----------------------MDIGEYLGD
. . : .
Mflv_0325|M.gilvum_PYR-GCK PVQALITWGP-FLLAVVYQAVSWVGASILYPSLFLLPLLATTLAIVAGVG
Mvan_0415|M.vanbaalenii_PYR-1 PAQALITWGP-FLAAVAYQAVSWVGASILYPSLLLLPLVATTLAIVLGVG
MSMEG_0619|M.smegmatis_MC2_155 PAGALATWWP-FLFGVAYQVFFNLVGWPTWGMIFASPFLIPALAALGITG
TH_3569|M.thermoresistible__bu PAGALVTWWP-LLFAVAYQVFTNLVGWPTWAMILASPVLIPLAITLGVAG
MAB_4783|M.abscessus_ATCC_1997 PAAAIVTWTP-LFYVFAYAATFAVMGTPIYAAIMGP---AAGISIPLAIT
MAV_4867|M.avium_104 LPAFLAANGP-LLFFVAYQVFFNAVGWPTWGAILTAP---FLLPLLLGIG
Mb3043c|M.bovis_AF2122/97 FIITLASNAQ-LLTEFAINASYVAVG--LLYAIAGVIDIVVEWVIGNLFG
Rv3018c|M.tuberculosis_H37Rv FIITLASNAQ-LLTEFAINASYVAVG--LLYAIAGVIDIVVEWVIGNLFG
MLBr_01828|M.leprae_Br4923 LAAAFASGNP-VTIGFTLLFTTIEAIGTIITDTIALVKTMIEQSFVLLPM
MMAR_4606|M.marinum_M PIGFLIAGVIGFFGGFAYGAVSDAVAGLLVAHSVSEAVAISLALASVLAL
MUL_4456|M.ulcerans_Agy99 PIGFLIAGVIGFFGGFAYGAVSDAVAGLLVAHSVSEAVAISLALASVLAL
: : . ..
Mflv_0325|M.gilvum_PYR-GCK QHLLSLLNTP-PAEEAAEEPAPAQSAPSRPDQQSFPATMSAPPPPSGAPI
Mvan_0415|M.vanbaalenii_PYR-1 AYLLENLPAP-AEDAPAEEPAASSPAPTRADQPSPAIAVSAPPPPSSAAA
MSMEG_0619|M.smegmatis_MC2_155 LVLLIDHVLNNPVDVPAEDEAPQEVAAAPRTDQPLAVGISPAGVPGSAAT
TH_3569|M.thermoresistible__bu LVMIADQAQP-----PAEEAAPEEDVAAP-------------------VR
MAB_4783|M.abscessus_ATCC_1997 LASLSQMPEAPPVDAPAETVPARIDQPHAVAMGGAPAPTASTAAP--TPT
MAV_4867|M.avium_104 LSSLLAAPAEIAPVAAPAAITPVLASNKPPTLPAAVALAPSVATPAGAPA
Mb3043c|M.bovis_AF2122/97 VVPLLGGPLLG---ALAAAVVPG------------------------VAG
Rv3018c|M.tuberculosis_H37Rv VVPLLGGPLLG---ALAAAVVPG------------------------VAG
MLBr_01828|M.leprae_Br4923 ILPLLTAPLAVATAGAAGSFAGLSELAGLVGVAPPGLPSAPPVAAVAPVV
MMAR_4606|M.marinum_M DFAVTAMVLSAVAVPLAAAIAVPIALP--------------------IAL
MUL_4456|M.ulcerans_Agy99 DFAVTAMVLSAVAVPLAAAIAVPIALP--------------------IAL
: .
Mflv_0325|M.gilvum_PYR-GCK AANTVSAGSPPAPGAPAAAAATFVPYVVAGRDPYEGFSPTVRDSTGA---
Mvan_0415|M.vanbaalenii_PYR-1 TVGTVATGTAPAPGAPAAATASFVPYAVAGRDPGTGFSPTVRDSTSA---
MSMEG_0619|M.smegmatis_MC2_155 AAAPAPAPAGTTVAAPAPAAATFVPYAVANRDPGEGFTPTLGNKSQV---
TH_3569|M.thermoresistible__bu AEPQNPLPLTXXX-------------------------------------
MAB_4783|M.abscessus_ATCC_1997 TTSPATPGSAPAP-TPPPAGAEGLGYAVRGDGPGFGFGPTIGASTGA---
MAV_4867|M.avium_104 STVAAGSGAAAAP-GPAAAAGNFAYLVAFGGDPDTGVGPTLSGRGGA---
Mb3043c|M.bovis_AF2122/97 LAGVAGLAAVPAVGAAAGAPAALVGSVAP-------------VSGGV---
Rv3018c|M.tuberculosis_H37Rv LAGVAGLAALPAVGAAAGAPAALVGSVAP-------------VSGGV---
MLBr_01828|M.leprae_Br4923 PPSMPTLASIPTPTPMPAPAASTAPVVTPPGPPPVTAPPSVTGAGVESFG
MMAR_4606|M.marinum_M PLGIDAYVRGSSDLGVGVADAGLRSVSASSLTQNIDTPTQLGGLAGV---
MUL_4456|M.ulcerans_Agy99 PLGIDAYVRGSSDLGVGVADAGLRSVSVSSLTQNIDTPTQLGGLAGV---
Mflv_0325|M.gilvum_PYR-GCK ------KAPAGTIPAAASGIAASAAERRKRRRRQKEEIKGRGYADAYADY
Mvan_0415|M.vanbaalenii_PYR-1 ------KAPASGIPAAASGVAASAAERRKRRRRQKDEIAGRAYADAYADY
MSMEG_0619|M.smegmatis_MC2_155 ------AAPASGVPAAASGVAASLASRRKRRRKKGAQIEERGYADAYMDY
TH_3569|M.thermoresistible__bu --------------------------------------------------
MAB_4783|M.abscessus_ATCC_1997 ------TAHAPSSAVSAAAALACNPATGKSRRRRRRTIDDRGYRHEYATM
MAV_4867|M.avium_104 ------KAPAATIPAAGAAAPARAEARARRRRRAALHDYSDEFLDMDSGF
Mb3043c|M.bovis_AF2122/97 ------VSPQARLVSAVEPAPASTSVS-----------------------
Rv3018c|M.tuberculosis_H37Rv ------VSPQARLVSAVEPAPASTSVS-----------------------
MLBr_01828|M.leprae_Br4923 YLVGRLPSTARGVVGTSVRQQSSAPDRIEAPDAAATPQEQARSRWRRRAK
MMAR_4606|M.marinum_M ----------QSVPGPNDAVAGIDQDSVRHG-------------------
MUL_4456|M.ulcerans_Agy99 ----------QSVPGPNDAVAGSDQDSVRHG-------------------
Mflv_0325|M.gilvum_PYR-GCK EELPDDGPPEQPAPRVTASTRGAGPMGFAGTVSRG-DEQAGGLTTLAGDS
Mvan_0415|M.vanbaalenii_PYR-1 EPEPDDEPPVRQEPRIAATERGAGPMGFAGTVSRD-AAQAGGLTTLPGDP
MSMEG_0619|M.smegmatis_MC2_155 EE-PDEDPAPQPEPRVRASERGSDAMGFTGTVTRH-DVTAAGLTTLTGDT
TH_3569|M.thermoresistible__bu --------------------------------------------------
MAB_4783|M.abscessus_ATCC_1997 DDHTPTGP--QDPVTAVASGTGAGRLGFAGVHTATTAVEATGLSTLDGDA
MAV_4867|M.avium_104 GVPPDYGAEEELAA-AVASGQGAGTLGFAGTQQRRKAFQAAGLTKLADDD
Mb3043c|M.bovis_AF2122/97 ---------------VLASDRGAGALGFVGTAGKESVGQPAGLTVLA-DE
Rv3018c|M.tuberculosis_H37Rv ---------------VLASDRGAGALGFVGTAGKESVGQPAGLTVLA-DE
MLBr_01828|M.leprae_Br4923 VTPFDSSGSPNPKAAPTASDQGAGTLGLAGTARQASSGPATGLVTLSNGT
MMAR_4606|M.marinum_M ----------------LAGSVGVGDVQSWGFVGTSGSVRGEPSGLSMLGA
MUL_4456|M.ulcerans_Agy99 ----------------LAGSVGVGDVQSWGFVGTSGSVRGEPSGLSMLGA
Mflv_0325|M.gilvum_PYR-GCK FGGGPREPMLPGTWDPDATDDRHTDGRDGHDGHDGKEKP
Mvan_0415|M.vanbaalenii_PYR-1 FGGGPKAPMLPGTWDPDTEPD------ERHNHHDGKDSQ
MSMEG_0619|M.smegmatis_MC2_155 FDDRPVTPMLPGTWDGDENPA------PSPDDPEGGPRR
TH_3569|M.thermoresistible__bu ---------------------------------------
MAB_4783|M.abscessus_ATCC_1997 EN--RTIPMLPGTWDVTDDDR------------------
MAV_4867|M.avium_104 FGGSPRMPMVPGTWEQDTQNG-------AHPTEPGKGG-
Mb3043c|M.bovis_AF2122/97 FGDGAPVPMLPGSWGPDLVGV---------AGDGGLVSV
Rv3018c|M.tuberculosis_H37Rv FGDGAPVPMLPGSWGPDLVGV---------AGDGGLVSV
MLBr_01828|M.leprae_Br4923 FSDSPRAPMLPRTWGADPTFCYN---AADIGPAGGWDDE
MMAR_4606|M.marinum_M ESGGLRVPVLPSSWDLS----------------------
MUL_4456|M.ulcerans_Agy99 ESGGLRVPVLPSSWDLSWSK-------------------