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TSPVWMGSPPEVHSALLSSGPGAASLQVSASAWTSLGAAYSSAADELTAVVVVGETETWEGMGAASYAAA HQPYVAWLMRNGAEAEAMAAEHEAMAAAYCAALAAMPTMGELAENHLTHGVLLGTNFLGINTVPIAVNEA DYERMWVQAATTMSAYDAASTVFAARAPQTTPAPRLIRSLGDDAPNVLPQAANVLGSWSDFWEEFVYNFF DIFTYAWDSIALLGMDIGEYLGDPIGFLIAGVIGFFGGFAYGAVSDAVAGLLVAHSVSEAVAISLALASV LALDFAVTAMVLSAVAVPLAAAIAVPIALPIALPLGIDAYVRGSSDLGVGVADAGLRSVSVSSLTQNIDT PTQLGGLAGVQSVPGPNDAVAGSDQDSVRHGLAGSVGVGDVQSWGFVGTSGSVRGEPSGLSMLGAESGGL RVPVLPSSWDLSWSK*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_4456 | - | - | 100% (436) | PPE family protein |
| M. ulcerans Agy99 | MUL_1208 | - | 4e-61 | 33.79% (506) | PPE family protein |
| M. ulcerans Agy99 | MUL_1202 | - | 8e-61 | 35.21% (514) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3047c | PPE47 | 7e-67 | 37.59% (439) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0325 | - | 5e-58 | 40.45% (314) | PPE protein |
| M. tuberculosis H37Rv | Rv3018c | PPE46 | 6e-67 | 37.99% (437) | PPE family protein |
| M. leprae Br4923 | MLBr_01828 | PPE | 1e-53 | 33.80% (426) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_4783 | - | 5e-59 | 36.87% (415) | PPE family protein |
| M. marinum M | MMAR_4606 | - | 0.0 | 98.85% (433) | PPE family protein |
| M. avium 104 | MAV_4867 | - | 3e-65 | 36.61% (478) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 1e-58 | 38.81% (353) | PPE family protein |
| M. thermoresistible (build 8) | TH_3569 | - | 5e-58 | 41.94% (310) | PUTATIVE PPE protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 2e-59 | 36.13% (429) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTS---PVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSL
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSS---PVWMALPPEVHSALLSSGPGPGSMLAAAATWQSL
MSMEG_0619|M.smegmatis_MC2_155 ----------MTA---PIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSL
TH_3569|M.thermoresistible__bu ---------MMTA---PIWMALPPEVHSALLSSGPGPGSLLAAASAWHAL
MAB_4783|M.abscessus_ATCC_1997 ----------MTA---PVWMAAPPEVHSALLSSGPGPGSLFAAADAWRSL
MAV_4867|M.avium_104 ----------MTSPFGPIWMASPPEVHSALLSAGPGPGPLLAAAGAWTSL
Mb3047c|M.bovis_AF2122/97 ----------MTA---PVWLASPPEVHSALLSAGPGPGSLQAAAAGWSAL
Rv3018c|M.tuberculosis_H37Rv ----------MTA---PVWLASPPEVHSALLSAGPGPGSLQAAAAGWSAL
MLBr_01828|M.leprae_Br4923 ----------MSA---PIWMASPPEVHSALLSRGPGSGPLLVAAEAWRSL
MUL_4456|M.ulcerans_Agy99 ----------MTS---PVWMGSPPEVHSALLSSGPGAASLQVSASAWTSL
MMAR_4606|M.marinum_M ----------MTS---PVWMGSPPEVHSALLSSGPGAASLQVSASAWTSL
::: *:*:. ******::** ***...: .:. * :*
Mflv_0325|M.gilvum_PYR-GCK SAEYASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSA
Mvan_0415|M.vanbaalenii_PYR-1 SAEYAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGA
MSMEG_0619|M.smegmatis_MC2_155 SAEYAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSA
TH_3569|M.thermoresistible__bu SAEYASAAAELSSVLANVQAGSWEGPSAERYVAAHAPYLAWLTQQSANSA
MAB_4783|M.abscessus_ATCC_1997 STEYSSAANELTTTLGSVRAGVWDGASAEQYQTAHVPYLSWLHETSAVSA
MAV_4867|M.avium_104 SAQYATAAAELSALLGEAQAGSWEGESAAQYAAAHLPYLAWLQQASADSA
Mb3047c|M.bovis_AF2122/97 SAEYAAVAQELSAVVAAVGAGVWQGPSAELFVAAYVPYVAWLVQASADSA
Rv3018c|M.tuberculosis_H37Rv SAEYAAVAQELSVVVAAVGAGVWQGPSAELFVAAYVPYVAWLVQASADSA
MLBr_01828|M.leprae_Br4923 SSVYAEMADELVALLVVVPVSSWDGSAAEAYVIAYLPYLGWLRQASVDSA
MUL_4456|M.ulcerans_Agy99 GAAYSSAADELTAVVVVGETETWEGMGAASYAAAHQPYVAWLMRNGAEAE
MMAR_4606|M.marinum_M GAAYSSAADELTAVVVVGETETWEGMGAASYAAAHQPYVAWLMRNGAEAE
.: *: * ** : *:* .: : *: **: ** . .. .
Mflv_0325|M.gilvum_PYR-GCK ATAVQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIA
Mvan_0415|M.vanbaalenii_PYR-1 AAAAQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIA
MSMEG_0619|M.smegmatis_MC2_155 AAAVQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIA
TH_3569|M.thermoresistible__bu ATAGRHETAAAAYSTALATMPTMAELTLNKTTHAVLVATNFLGINTIPIA
MAB_4783|M.abscessus_ATCC_1997 GVAAQTETAATAYSEALATMPTLGELAANHATHGALVATNFFGINTIPIA
MAV_4867|M.avium_104 GAAAQQEVAATAYTTALAAMPTLAELAANHTIHGVLLATNFFGINTIPIA
Mb3047c|M.bovis_AF2122/97 AAAGEHEAAAAGYVCALAEMPTLPELAANHLTHAVLVATNFFGINTIPIA
Rv3018c|M.tuberculosis_H37Rv AAAGEHEAAAAGYVCALAEMPTLPELAANHLTHAVLVATNFFGINTIPIA
MLBr_01828|M.leprae_Br4923 VMAAHYETMATAYITTLAMMPTLAELAANRTAHTVLVTTNFFGINTIPIA
MUL_4456|M.ulcerans_Agy99 AMAAEHEAMAAAYCAALAAMPTMGELAENHLTHGVLLGTNFLGINTVPIA
MMAR_4606|M.marinum_M AMAAEHEAMAAAYCAALAAMPTMGELAENHLTHGVLLGTNFFGINTVPIA
* . :. *:.* :** ***: **: *: * .*: ***:****:***
Mflv_0325|M.gilvum_PYR-GCK LNEADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLPGVGEAGR
Mvan_0415|M.vanbaalenii_PYR-1 MTEADYVRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPGVGEAGR
MSMEG_0619|M.smegmatis_MC2_155 LNEADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPGVGEAGS
TH_3569|M.thermoresistible__bu LNEADYVRMWIQAATSMSTYQAVAGTAVMSAPASSPAPLLLAPGVSEAAD
MAB_4783|M.abscessus_ATCC_1997 VNEADYIRMWIQAATVMSTYQAVSESSVSAAPPTSPAPPVLSPDSGAAAR
MAV_4867|M.avium_104 VNEADYARMWVQAATTMGTYQAVAGSALAAAPRTAPAPSIVKPG-GEANN
Mb3047c|M.bovis_AF2122/97 LNEADYVRMWVQAATVMSAYEAVVGAALVATPHTGPAPVIVKPGANEASN
Rv3018c|M.tuberculosis_H37Rv LNEADYVRMWVQAATVMSAYEAVVGAALVATPHTGPAPVIVKPGANEASN
MLBr_01828|M.leprae_Br4923 RNEIDYVRMWVEAAIAMGTYQEVSTVVVDSAPEAIAAPQIMASDALEASS
MUL_4456|M.ulcerans_Agy99 VNEADYERMWVQAATTMSAYDAASTVFAARAPQTTPAPRLIRSLGDDAPN
MMAR_4606|M.marinum_M VNEADYARMWVQAATAMSAYDAASTVFAARAPQTTPAPRLIRSLGDDAPN
.* ** ***::** *.:*: . :* : .** :: . *
Mflv_0325|M.gilvum_PYR-GCK AAADMSAFAA--------------------QPMAAQAGAAFDVSNIIADI
Mvan_0415|M.vanbaalenii_PYR-1 AAADVTAFAA--------------------QAQAAEAGSALDLSNIIADL
MSMEG_0619|M.smegmatis_MC2_155 ASASVQQMSA--------------------QATAAESGSSLDLSSIISDL
TH_3569|M.thermoresistible__bu AMATTQQIGS--------------------QATAADSGTALNLSDLIANL
MAB_4783|M.abscessus_ATCC_1997 TAA---------------------------QDATKPPPIVPDPNDPIEML
MAV_4867|M.avium_104 LAAN-----------------------------AAQNSS----GDWWQNF
Mb3047c|M.bovis_AF2122/97 AVA----------------------------AATITPFPFGELAKFLEMA
Rv3018c|M.tuberculosis_H37Rv AVA----------------------------AATITPFPWHEIVQFLEET
MLBr_01828|M.leprae_Br4923 DQPSPTAPSQSPQVQNWLQWLQKIGYTDFYNTLVQPLITSLTNHPFFQGM
MUL_4456|M.ulcerans_Agy99 VLP-------------------------------QAANVLGSWSDFWEEF
MMAR_4606|M.marinum_M VLP-------------------------------QAANVLGSWSDFWEEF
.
Mflv_0325|M.gilvum_PYR-GCK IRLYGEVLRFLFEPIFNF--------------LRDPIGNTFALITDFLTN
Mvan_0415|M.vanbaalenii_PYR-1 IRAYGELLRFLFEPIFDF--------------LRDPLGNTIKLITDFLTN
MSMEG_0619|M.smegmatis_MC2_155 LNQYLQGVPGGQ-AILDF--------------LKDPLGNLGRLLTDFMTN
TH_3569|M.thermoresistible__bu LQYYQDYLDQLFGPIVDF--------------LRDPIGNLFQLIDDFLTN
MAB_4783|M.abscessus_ATCC_1997 LKNSQHFL-GMYRALKGL--------------ITDPVGTIVRIIIDFSTN
MAV_4867|M.avium_104 IQQLSQFF-----------------------------QNIQKMLQDFWAN
Mb3047c|M.bovis_AF2122/97 AQAFTEVG--------------------------ELIMKSAEAWAVGFVE
Rv3018c|M.tuberculosis_H37Rv FAAYDQYL--------------------------SALLSELPAVAWVWFQ
MLBr_01828|M.leprae_Br4923 FSGFDPWLPSLGNPLSFLSPFNIAFALGTPMDIGSYVGYLSQTFAFIGAD
MUL_4456|M.ulcerans_Agy99 VYNFFDIFTY----------------------AWDSIALLGMDIGEYLGD
MMAR_4606|M.marinum_M VYNFFDIFTY----------------------AWDSIALLGMDIGEYLGD
:
Mflv_0325|M.gilvum_PYR-GCK PVQALITWGP-FLLAVVYQAVSWVGASILYPSLFLLPLLATTLAIVAGVG
Mvan_0415|M.vanbaalenii_PYR-1 PAQALITWGP-FLAAVAYQAVSWVGASILYPSLLLLPLVATTLAIVLGVG
MSMEG_0619|M.smegmatis_MC2_155 PAGALATWWP-FLFGVAYQVFFNLVGWPTWGMIFASPFLIPALAALGITG
TH_3569|M.thermoresistible__bu PAGALVTWWP-LLFAVAYQVFTNLVGWPTWAMILASPVLIPLAITLGVAG
MAB_4783|M.abscessus_ATCC_1997 PAAAIVTWTP-LFYVFAYAATFAVMGTPIYAAIMGP---AAGISIPLAIT
MAV_4867|M.avium_104 LPAFLAANGP-LLFFVAYQVFFNAVGWPTWGAILTAP---FLLPLLLGIG
Mb3047c|M.bovis_AF2122/97 LITGLVNFEP-WLVLTGMIDMFFATVGFALGVFVLVPLLEFAVVLELAIL
Rv3018c|M.tuberculosis_H37Rv LFVDILGFNI-IGFIITLASNAQLLTEFAINASYVAVGLLYAIAGVIDIV
MLBr_01828|M.leprae_Br4923 LAAAFASGNP-VTIGFTLLFTTIEAIGTIITDTIALVKTMIEQSFVLLPM
MUL_4456|M.ulcerans_Agy99 PIGFLIAGVIGFFGGFAYGAVSDAVAGLLVAHSVSEAVAISLALASVLAL
MMAR_4606|M.marinum_M PIGFLIAGVIGFFGGFAYGAVSDAVAGLLVAHSVSEAVAISLALASVLAL
:
Mflv_0325|M.gilvum_PYR-GCK QHLLSLLNTP-PAEEAAEEPAPAQSAPSRPDQQSFPATMSAPPPPSGAPI
Mvan_0415|M.vanbaalenii_PYR-1 AYLLENLPAP-AEDAPAEEPAASSPAPTRADQPSPAIAVSAPPPPSSAAA
MSMEG_0619|M.smegmatis_MC2_155 LVLLIDHVLNNPVDVPAEDEAPQEVAAAPRTDQPLAVGISPAGVPGSAAT
TH_3569|M.thermoresistible__bu LVMIADQAQP-----PAEEAAPEEDVAAP-------------------VR
MAB_4783|M.abscessus_ATCC_1997 LASLSQMPEAPPVDAPAETVPARIDQPHAVAMGGAPAPTASTAAP--TPT
MAV_4867|M.avium_104 LSSLLAAPAEIAPVAAPAAITPVLASNKPPTLPAAVALAPSVATPAGAPA
Mb3047c|M.bovis_AF2122/97 SIGWIISNIFGAIPVLAGPLLGALAAAVVPG----------------VAG
Rv3018c|M.tuberculosis_H37Rv -VEWVIGNLFGVVPLLGGPLLGALAAAVVPG----------------VAG
MLBr_01828|M.leprae_Br4923 ILPLLTAPLAVATAGAAGSFAGLSELAGLVGVAPPGLPSAPPVAAVAPVV
MUL_4456|M.ulcerans_Agy99 DFAVTAMVLSAVAVPLAAAIAVPIALPIALPLG-------------IDAY
MMAR_4606|M.marinum_M DFAVTAMVLSAVAVPLAAAIAVPIALPIALPLG-------------IDAY
Mflv_0325|M.gilvum_PYR-GCK AANTVSAGSPPAPGAPAAAAATFVPYVVAGRDPYEGFSPTVR--------
Mvan_0415|M.vanbaalenii_PYR-1 TVGTVATGTAPAPGAPAAATASFVPYAVAGRDPGTGFSPTVR--------
MSMEG_0619|M.smegmatis_MC2_155 AAAPAPAPAGTTVAAPAPAAATFVPYAVANRDPGEGFTPTLG--------
TH_3569|M.thermoresistible__bu AEPQNPLPLTXXX-------------------------------------
MAB_4783|M.abscessus_ATCC_1997 TTSPATPGSAPAP-TPPPAGAEGLGYAVRGDGPGFGFGPTIG--------
MAV_4867|M.avium_104 STVAAGSGAAAAP-GPAAAAGNFAYLVAFGGDPDTGVGPTLS--------
Mb3047c|M.bovis_AF2122/97 VTGLAGLAAVPAVGAAAGAPAALVGSVAP---------------------
Rv3018c|M.tuberculosis_H37Rv LAGVAGLAALPAVGAAAGAPAALVGSVAP---------------------
MLBr_01828|M.leprae_Br4923 PPSMPTLASIPTPTPMPAPAASTAPVVTPPGPPPVTAPPSVTGAGVESFG
MUL_4456|M.ulcerans_Agy99 VRGSSDLGVGVADAGLRSVSVSSLTQNIDTP-------------------
MMAR_4606|M.marinum_M VRGSSDLGVGVADAGLRSVSASSLTQNIDTP-------------------
Mflv_0325|M.gilvum_PYR-GCK -DSTGAKAPAGTIPAAASGIAASAAERRKRRRRQKEEIKGRGYADAYADY
Mvan_0415|M.vanbaalenii_PYR-1 -DSTSAKAPASGIPAAASGVAASAAERRKRRRRQKDEIAGRAYADAYADY
MSMEG_0619|M.smegmatis_MC2_155 -NKSQVAAPASGVPAAASGVAASLASRRKRRRKKGAQIEERGYADAYMDY
TH_3569|M.thermoresistible__bu --------------------------------------------------
MAB_4783|M.abscessus_ATCC_1997 -ASTGATAHAPSSAVSAAAALACNPATGKSRRRRRRTIDDRGYRHEYATM
MAV_4867|M.avium_104 -GRGGAKAPAATIPAAGAAAPARAEARARRRRRAALHDYSDEFLDMDSGF
Mb3047c|M.bovis_AF2122/97 -VSGGVVSPQARLVSAVEPAPASTSVS-----------------------
Rv3018c|M.tuberculosis_H37Rv -VSGGVVSPQARLVSAVEPAPASTSVS-----------------------
MLBr_01828|M.leprae_Br4923 YLVGRLPSTARGVVGTSVRQQSSAPDRIEAPDAAATPQEQARSRWRRRAK
MUL_4456|M.ulcerans_Agy99 -TQLGGLAGVQSVPGPNDAVAGSDQDSVRHG-------------------
MMAR_4606|M.marinum_M -TQLGGLAGVQSVPGPNDAVAGIDQDSVRHG-------------------
Mflv_0325|M.gilvum_PYR-GCK EELPDDGPPEQPAPRVTASTRGAGPMGFAGTVSRG-DEQAGGLTTLAGDS
Mvan_0415|M.vanbaalenii_PYR-1 EPEPDDEPPVRQEPRIAATERGAGPMGFAGTVSRD-AAQAGGLTTLPGDP
MSMEG_0619|M.smegmatis_MC2_155 EE-PDEDPAPQPEPRVRASERGSDAMGFTGTVTRH-DVTAAGLTTLTGDT
TH_3569|M.thermoresistible__bu --------------------------------------------------
MAB_4783|M.abscessus_ATCC_1997 DDHTPTGP--QDPVTAVASGTGAGRLGFAGVHTATTAVEATGLSTLDGDA
MAV_4867|M.avium_104 GVPPDYGAEEELAA-AVASGQGAGTLGFAGTQQRRKAFQAAGLTKLADDD
Mb3047c|M.bovis_AF2122/97 ---------------VLASDRGAGALGFVGTAGKESVGQPAGLTVLA-DE
Rv3018c|M.tuberculosis_H37Rv ---------------VLASDRGAGALGFVGTAGKESVGQPAGLTVLA-DE
MLBr_01828|M.leprae_Br4923 VTPFDSSGSPNPKAAPTASDQGAGTLGLAGTARQASSGPATGLVTLSNGT
MUL_4456|M.ulcerans_Agy99 ----------------LAGSVGVGDVQSWGFVGTSGSVRGEPSGLSMLGA
MMAR_4606|M.marinum_M ----------------LAGSVGVGDVQSWGFVGTSGSVRGEPSGLSMLGA
Mflv_0325|M.gilvum_PYR-GCK FGGGPREPMLPGTWDPDATDDRHTDGRDGHDGHDGKEKP
Mvan_0415|M.vanbaalenii_PYR-1 FGGGPKAPMLPGTWDPDTEPD------ERHNHHDGKDSQ
MSMEG_0619|M.smegmatis_MC2_155 FDDRPVTPMLPGTWDGDENPA------PSPDDPEGGPRR
TH_3569|M.thermoresistible__bu ---------------------------------------
MAB_4783|M.abscessus_ATCC_1997 EN--RTIPMLPGTWDVTDDDR------------------
MAV_4867|M.avium_104 FGGSPRMPMVPGTWEQDTQNG-------AHPTEPGKGG-
Mb3047c|M.bovis_AF2122/97 FGDGAPVPMLPGSWGPDLVGV---------AGDGGLVSV
Rv3018c|M.tuberculosis_H37Rv FGDGAPVPMLPGSWGPDLVGV---------AGDGGLVSV
MLBr_01828|M.leprae_Br4923 FSDSPRAPMLPRTWGADPTFCYN---AADIGPAGGWDDE
MUL_4456|M.ulcerans_Agy99 ESGGLRVPVLPSSWDLSWSK-------------------
MMAR_4606|M.marinum_M ESGGLRVPVLPSSWDLS----------------------