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M. marinum M MMAR_4320 (-)

annotation: PPE family protein
coordinates: 5318444 - 5321764
length: 1106

MNFMMLPPEINSARIFAGAGVGPTLAAAAAWDGLAADLASAAQSFSAITVGLVGEAWQGAAATAMAAAAR
PYASWLGTAAARAAVTAAQANAAAAVFEAAQAATAHPELVAANRNQLVSLVVSNLFGQNAPAIALTEAAY
DQLWAQDVAAMAGYHSGASAVAAQLAPWQQALRTLQNRVAGATTALPSSGPAAAAALPGAAAAVGFPVLH
IGNIGFANLSVGNIGDYNLGSGNTGSFNLGSGNIGDASLGSGNAGNANLGSGNQGFFNLGSGNTGNINFG
SGNRLGSLNFGFGNAVGDANFGWGNAGSSNLGLGNFGSLNWGSGNNGSTNFGSGNTGSLNLGSGNAGDSN
VGFGNFGSNNVGFGNNGNNNIGIGLNGDDLIGIGALNSGAGNLGFGNSGTNNIGFFNSGDNNIGFFNSGS
GNFGFENAGDINTGFWNGRDTNTGFGNSGLSNFGFGNSGVNNVGAGNGGSSNVGLGNAGLLNTGSFNSGN
FNTGDFNSGSMNTGYFNSSGHNTGLGNSGFTNTGFFNSGDLNTGMGSPEDQSVANSGFRNAGSGNSGFNN
TGSFSSGFFNSTNSNSGFLNAGGTVNSGINNSGNTNAGIGNLGDDNFGLFNNGTFNTGAGNSSGGAVFPY
TSGLFNSGNGSSGVFNAGDEQSGFFGTSGLVLTGTDGLAAATTSGLPALDLPAPNLGIGNAGVGNLGLGN
IGDYNLGSGNTGDANFGFGNIGQANLGSGNAGNTNLGSGNTGSTNFGSGNIGALNLGSGNHGDANLGFGN
FGNGNIGSGNHGAGNFGSGNTGSRNLGSGNAGSTNFGSGNHGNSNVGLGNFGNNNLGLGNNGSNNIGFGL
TGDNLVGIGALNSGAGNLGFGNTGDNNIGLFNSGDNNVGFFNSGDGNFGLANSGDTNTGLWNAGSTNTGF
GNAGSADFGFGNAGDRNMGFGNAGAANMGAGNSGSYNTGSFNSGTLNTGDFNGGDHNTGWGNSGNTNTGG
INSGDLNTGFGSSADQAVTNSGFGNNGSGNSGFNNTGDTNSGFHNANTSALFSGHSGLLNAGGSQSVGIN
NTGSFNTGLFNTGFRTAGIANSATNGLLTATSGVANSGNNSSGGFNANPDQSGFFN
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. marinum MMMAR_4320--100% (1106)PPE family protein
M. marinum MMMAR_4319-0.061.41% (666) PPE family protein
M. marinum MMMAR_1139-0.059.64% (659) PPE family protein

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb1166cPPE160.064.08% (657) PPE family protein
M. gilvum PYR-GCKMflv_5091-5e-4327.91% (842) triple helix repeat-containing collagen
M. tuberculosis H37RvRv1135cPPE160.064.08% (657) PPE family protein
M. leprae Br4923MLBr_01182-3e-2942.77% (166) PPE-family protein
M. abscessus ATCC 19977MAB_4284c-1e-2827.53% (603) hypothetical protein MAB_4284c
M. avium 104MAV_4704-2e-5151.22% (205) PPE family protein
M. smegmatis MC2 155MSMEG_0868-4e-4927.62% (927) hypothetical protein MSMEG_0868
M. thermoresistible (build 8)TH_3113-1e-2537.56% (197) PUTATIVE PPE protein
M. ulcerans Agy99MUL_0965-0.063.07% (907) PPE family protein
M. vanbaalenii PYR-1Mvan_1264-5e-4428.07% (798) triple helix repeat-containing collagen

CLUSTAL 2.0.9 multiple sequence alignment


MMAR_4320|M.marinum_M               --------------------------------------------------
MUL_0965|M.ulcerans_Agy99           --------------------------------------------------
Mb1166c|M.bovis_AF2122/97           --------------------------------------------------
Rv1135c|M.tuberculosis_H37Rv        --------------------------------------------------
MAV_4704|M.avium_104                --------------------------------------------------
MLBr_01182|M.leprae_Br4923          --------------------------------------------------
TH_3113|M.thermoresistible__bu      --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_0868|M.smegmatis_MC2_155      MHERLRERAGGVRKTLSDFAEGAGLKPSDTDDTRSPLRKPKFPAALAPES
MAB_4284c|M.abscessus_ATCC_199      --------------------------------------------------
                                                                                      

MMAR_4320|M.marinum_M               --------------------------------------------------
MUL_0965|M.ulcerans_Agy99           --------------------------------------------------
Mb1166c|M.bovis_AF2122/97           --------------------------------------------------
Rv1135c|M.tuberculosis_H37Rv        --------------------------------------------------
MAV_4704|M.avium_104                --------------------------------------------------
MLBr_01182|M.leprae_Br4923          --------------------------------------------------
TH_3113|M.thermoresistible__bu      --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1       -------------------MMFLAPPGGPGPISAAIQLTSTGSEATEP--
MSMEG_0868|M.smegmatis_MC2_155      PLPDLKPRWERPTTAPDSETPSITQPQGRDTAADPAEQQATSTNTTDQPT
MAB_4284c|M.abscessus_ATCC_199      --------------------------------------------------
                                                                                      

MMAR_4320|M.marinum_M               --------------------------------------------------
MUL_0965|M.ulcerans_Agy99           --------------------------------------------------
Mb1166c|M.bovis_AF2122/97           --------------------------------------------------
Rv1135c|M.tuberculosis_H37Rv        --------------------------------------------------
MAV_4704|M.avium_104                --------------------------------------------------
MLBr_01182|M.leprae_Br4923          --------------------------------------------------
TH_3113|M.thermoresistible__bu      --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK          --------------------------------------MVTFGGGATPTP
Mvan_1264|M.vanbaalenii_PYR-1       ------------------------------------WYVVSFGGSGAPTP
MSMEG_0868|M.smegmatis_MC2_155      SDSLGAQPTAQVARQVQAPATDPAPAAPSLRPISGLLSVVTLGTTLIPNA
MAB_4284c|M.abscessus_ATCC_199      ------------------------------------MSIIDFILNLFRDP
                                                                                      

MMAR_4320|M.marinum_M               --------------------------------------------------
MUL_0965|M.ulcerans_Agy99           --------------------------------------------------
Mb1166c|M.bovis_AF2122/97           --------------------------------------------------
Rv1135c|M.tuberculosis_H37Rv        --------------------------------------------------
MAV_4704|M.avium_104                --------------------------------------------------
MLBr_01182|M.leprae_Br4923          --------------------------------------------------
TH_3113|M.thermoresistible__bu      --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK          ----------------------------------------TSLGAAAVDL
Mvan_1264|M.vanbaalenii_PYR-1       ----------------------------------------NNLAASLVDL
MSMEG_0868|M.smegmatis_MC2_155      PTEPADMPGVWAVMAWARRQPMYSDPAMRTTVNPQAQLPVPTVASAVLDP
MAB_4284c|M.abscessus_ATCC_199      ----------------------------------------VEAASYVADP
                                                                                      

MMAR_4320|M.marinum_M               -----------------------------------MN---FMMLPPEINS
MUL_0965|M.ulcerans_Agy99           -----------------------------------MN---FIMLPPEINS
Mb1166c|M.bovis_AF2122/97           -----------------------------------MS---FLVLPPEVNS
Rv1135c|M.tuberculosis_H37Rv        -----------------------------------MS---FLVLPPEVNS
MAV_4704|M.avium_104                -----------------------------------MTNPHFAWLPPEVNS
MLBr_01182|M.leprae_Br4923          -------------------------------------MFDFAALSPETNS
TH_3113|M.thermoresistible__bu      -----------------------------------------MALPPEVHS
Mflv_5091|M.gilvum_PYR-GCK          S------------------------GTSCG----------LICNGQDGTG
Mvan_1264|M.vanbaalenii_PYR-1       S------------------------GTSCG----------LICNGQDGTG
MSMEG_0868|M.smegmatis_MC2_155      TQIVNWLIYQPLHAAGQQFWVVSPIGSTLGGVINTISGQYLIGNGINGTA
MAB_4284c|M.abscessus_ATCC_199      -------------------------------------EAALANAGLSAVS
                                                                                  .  .

MMAR_4320|M.marinum_M               ARIFAGAGVGPTLAAAAAWDGLAADLASAA--QSFSAITVGLVGEAWQGA
MUL_0965|M.ulcerans_Agy99           ARIFAGAGVGPTLAAAAAWDALAADLASAA--QSFAAITVGLVGEAWQGA
Mb1166c|M.bovis_AF2122/97           ALMFAGAGSGPTLAAAAAWDGLAAELGQAA--NSFSSATAALADTAWQGP
Rv1135c|M.tuberculosis_H37Rv        ALMFAGAGSGPTLAAAAAWDGLAAELGQAA--NSFSSATAALADTAWQGP
MAV_4704|M.avium_104                ALIYSGPGPGPLLAAAAAWDGLAEELASSA--QSFSSVTSDLASGSWQGA
MLBr_01182|M.leprae_Br4923          TRMYLGPGSSPILTAAAAWVVLAKELTAAA--QGLQSAVEALLT-TFEGE
TH_3113|M.thermoresistible__bu      TLLRTGPGPGALSAAADAWRMLSDEYRAAA--VELAAVVSQTCATAWEGV
Mflv_5091|M.gilvum_PYR-GCK          QN-----GGILFGNGGSGWNSDVVGMDGGN--GGNGGLFGGNGGNGGNGL
Mvan_1264|M.vanbaalenii_PYR-1       QN-----GGILFGNGGSGWNSEIAGVSGGN--GGNAGLFGGNGGNGGNGL
MSMEG_0868|M.smegmatis_MC2_155      DNPNGGTGGLLFGDGGHGYDGSAAGLAGGN--GGNAGLFG-NGGNGGVGW
MAB_4284c|M.abscessus_ATCC_199      AAQVGAVMPVVAESVASNYGYQSQWVNTGNPIHDLSGNLQNYYAAQPDGP
                                                   .  :         .       .           * 

MMAR_4320|M.marinum_M               AATAMAAAARPYASWLGTAAARAAVTAAQANAAAAVFEAAQAATAHPELV
MUL_0965|M.ulcerans_Agy99           AATAMAAAARPYASWLGTAAARAAVTAAQANAAAAVFEAAQAATAHPELV
Mb1166c|M.bovis_AF2122/97           AATAMAAAAAPYASWLSTAATRALSAAAQAKAAAAVYEAARAATVDPLLV
Rv1135c|M.tuberculosis_H37Rv        AATAMAAAAAPYASWLSTAATRALSAAAQAKAAAAVYEAARAATVDPLLV
MAV_4704|M.avium_104                SSAAMMTVANQYVSWLSAAAAQAEEVSHQASAIATAFEVALAATVQPAVV
MLBr_01182|M.leprae_Br4923          SAAALAERVTPYEKWLTQNAASAELTATQLTVAANAYETAFTMTVPPLMV
TH_3113|M.thermoresistible__bu      GADAYAAAHGPYLFWLTDTAAAAAAAGAQLEAAAAAHASALAAMPTMAEL
Mflv_5091|M.gilvum_PYR-GCK          GGGNGGNGGNAGAFALFGNGGNGGNGGVGVVGATGAVG--APGVAGATGA
Mvan_1264|M.vanbaalenii_PYR-1       GSGDGGNGGDAGLFSLFGRGGNGGNGGVGIAGATGAVG--APGVAGATGA
MSMEG_0868|M.smegmatis_MC2_155      AGLDGGNGGSGG--LLMGIGGAGGAGGVGADGTSAHVDGGTGGTGGTGGG
MAB_4284c|M.abscessus_ATCC_199      SILSPSLLSPRDNDFLSHNDTDFASHNPIASGNQVMSPSGNVDSFNRGPL
                                    .              *                                  

MMAR_4320|M.marinum_M               AANRNQLVSLVVSNLFGQNAPAIALTEAAYDQLWAQD-------------
MUL_0965|M.ulcerans_Agy99           AANRNQLVSLVVSNLFGQNAPAIASTEAAYDQLWAQD-------------
Mb1166c|M.bovis_AF2122/97           AANRHQLVSLVLSNLFGQNAPAIAATEAAYEQLWAAD-------------
Rv1135c|M.tuberculosis_H37Rv        AANRHQLVSLVLSNLFGQNAPAIAATEAAYEQLWAAD-------------
MAV_4704|M.avium_104                AANRALVQALAATNWLGQNTPAIADIEAAYEQMWASD-------------
MLBr_01182|M.leprae_Br4923          FVNRAQACLLIMSNIFGQNSTAIAEKEAEYTEMWIQD-------------
TH_3113|M.thermoresistible__bu      TANRTTHAALVATNFFGVNTIPIAVNEADYARMWIQA-------------
Mflv_5091|M.gilvum_PYR-GCK          TGVTSGVVGGNGEDAVGYGATGAAGAAGAAGAAGAAG-------------
Mvan_1264|M.vanbaalenii_PYR-1       TGVTSNVTGGNGADAVGYGATGAAGAAGAAGAAGKAG-------------
MSMEG_0868|M.smegmatis_MC2_155      TGGTGGIGGTGGGLFGLLGHSGSTGAAGAAGNGGDGGNGGFGYVLIAGPN
MAB_4284c|M.abscessus_ATCC_199      LDLSFGDLQFGNRDTTAIGDGAVAVGGSNSGPIASGQ-------------
                                                      .    :   .                      

MMAR_4320|M.marinum_M               VAAMAGYHSGASAVAAQLAPWQQALRTLQNRVAGATTAL--------PSS
MUL_0965|M.ulcerans_Agy99           VAAMAGYHSGASAVAAQLAPWQQALRTLQNRVAGATTAL--------PPP
Mb1166c|M.bovis_AF2122/97           VAAMVSYHSGASAVAAQLAPWAQAVRALPN--------------------
Rv1135c|M.tuberculosis_H37Rv        VAAMVSYHSGASAVAAQLAPWAQAVRALPN--------------------
MAV_4704|M.avium_104                VAAMFGYHADASAAVAKLPPWNEVLQ------------------------
MLBr_01182|M.leprae_Br4923          AAAMTSYQASVLEAVGATKAFTAPPLG-----------------------
TH_3113|M.thermoresistible__bu      ATTMATYEAVASAAVSATPRTVAPPPILGAG-------------------
Mflv_5091|M.gilvum_PYR-GCK          -AVGSAGAAGEAGETGTWG--NAGLPGKAGDAGGAG--------------
Mvan_1264|M.vanbaalenii_PYR-1       -AVGSAGTAGSAGAPGVWG--NAGLPGAAGAAGGAG--------------
MSMEG_0868|M.smegmatis_MC2_155      VTVGSETRGGTGGAGGTGGQSTAAGPGKGGGGGGGGGGAILIGANGGTVD
MAB_4284c|M.abscessus_ATCC_199      GSTAVNGDVRDSNIINADHGSNVGVDQSQTRVGGDYTN------------
                                     :.                                               

MMAR_4320|M.marinum_M               GPAAAAALPGAAAAVGFPVLHIGNIGFAN-------------LSVGNIGD
MUL_0965|M.ulcerans_Agy99           GPAAAAALPG-AAAVGFPVLHIGNIGFAN-------------LSVGNIGD
Mb1166c|M.bovis_AF2122/97           --PTAPALASGPAALAIPALGIGNTGIGNI------------FSIGNIGD
Rv1135c|M.tuberculosis_H37Rv        --PTAPALASGPAALAIPALGIGNTGIGNI------------FSIGNIGD
MAV_4704|M.avium_104                -----------------------NLGFSN---------------------
MLBr_01182|M.leprae_Br4923          ---------------------VNEVGLAQ-----------------EVVE
TH_3113|M.thermoresistible__bu      -------TGESATAAITGAHVTAELRAAES------------RTLLDEIN
Mflv_5091|M.gilvum_PYR-GCK          --AVGAAGAAG------TVGTAGATGGTG---------------TGANGG
Mvan_1264|M.vanbaalenii_PYR-1       --AIGTAGVAG------AAGTAGATGGTG---------------VGGNGG
MSMEG_0868|M.smegmatis_MC2_155      GHAIGGNGGNGGNGSTTAAGGNGGTGGTGRVIAEGTGSTAEGTATGGDGG
MAB_4284c|M.abscessus_ATCC_199      ---VSGHGSADIDKSVTVVDDHSQRNTTNIN-----------DSFNTDRS
                                                                                      

MMAR_4320|M.marinum_M               YNLGSGNTGSFNLG---------------SGNIGDASLGSGNAGNANLGS
MUL_0965|M.ulcerans_Agy99           YNLGSGNTGSFNLG---------------SGNIGDASLGSGNAG------
Mb1166c|M.bovis_AF2122/97           YNLGNGNTGNANLG---------------SGNTGQANLGSGNTG------
Rv1135c|M.tuberculosis_H37Rv        YNLGNGNTGNANLG---------------SGNTGQANLGSGNTG------
MAV_4704|M.avium_104                ----ASTAVTRPAG---------------SGAVARG-YTSRIAG------
MLBr_01182|M.leprae_Br4923          EVVEEVVEEVVEAE---------------QAISQAALDQAVNEG------
TH_3113|M.thermoresistible__bu      ELIDRLFAPLFPPG---------------FADALPDGLLGTLLAP-----
Mflv_5091|M.gilvum_PYR-GCK          AGGVGGVGGTGAAG--------------AAGGAGGLGETGTTGGAG----
Mvan_1264|M.vanbaalenii_PYR-1       AGQAGGIGGTGAAG--------------AAGQAGTAGETGVTGGVG----
MSMEG_0868|M.smegmatis_MC2_155      HSTGTGIGGNGGIGSVYAYGNNGAVSGTATGGRGGDGIDGGTGGAG----
MAB_4284c|M.abscessus_ATCC_199      TNIGSGNTTNTEIG------------SHNQANIGTSTSAGGSAAVG----
                                                                  .        .   .      

MMAR_4320|M.marinum_M               GNQGFFNLGSGNTGNINFGSGNRLGSLNFGFGNAVGDANFGWGNAGSSNL
MUL_0965|M.ulcerans_Agy99           --------------------------------------------------
Mb1166c|M.bovis_AF2122/97           --------------------------------------------------
Rv1135c|M.tuberculosis_H37Rv        --------------------------------------------------
MAV_4704|M.avium_104                --------------------------------------------------
MLBr_01182|M.leprae_Br4923          --------------------------------------------------
TH_3113|M.thermoresistible__bu      --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_0868|M.smegmatis_MC2_155      --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      --------------------------------------------------
                                                                                      

MMAR_4320|M.marinum_M               GLGNFGSLNWGSGNNGSTNFGSGNTGSLNLGSGNAGDSNVGFGNFGSNNV
MUL_0965|M.ulcerans_Agy99           ------------------------------------DSNVGFGNFGSNNV
Mb1166c|M.bovis_AF2122/97           --------------------------------------------------
Rv1135c|M.tuberculosis_H37Rv        --------------------------------------------------
MAV_4704|M.avium_104                --------------------------------------------------
MLBr_01182|M.leprae_Br4923          --------------------------------------------------
TH_3113|M.thermoresistible__bu      --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1       --------------------------------------------------
MSMEG_0868|M.smegmatis_MC2_155      --------------------------------------------------
MAB_4284c|M.abscessus_ATCC_199      --------------------------------------------------
                                                                                      

MMAR_4320|M.marinum_M               GFGNNGNNNIGIGLNGDDLIGIGALNSGAGNLGFGNSGTNNIGFFNSGDN
MUL_0965|M.ulcerans_Agy99           GIGNNGNNNIGIGLNGDDLIGIGALNSGAGNLGFGNSGTNNIGFFNSGDN
Mb1166c|M.bovis_AF2122/97           --------------------------------------------------
Rv1135c|M.tuberculosis_H37Rv        --------------------------------------------------
MAV_4704|M.avium_104                --------------------------------------------------
MLBr_01182|M.leprae_Br4923          --------------------------------------------------
TH_3113|M.thermoresistible__bu      --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK          -----------------------------------GVGGQ--GTAGGTGG
Mvan_1264|M.vanbaalenii_PYR-1       -----------------------------------GIGGQ--GTEGGTGG
MSMEG_0868|M.smegmatis_MC2_155      -----------------------------------GMGEIYSGADGEATG
MAB_4284c|M.abscessus_ATCC_199      --------------------------------------------------
                                                                                      

MMAR_4320|M.marinum_M               NIGFFNSGSGNFGFENAGDINTGFWNGRDTNTGFGNSGLSNFGFGNSGVN
MUL_0965|M.ulcerans_Agy99           NIGFFNSGSGNFGFENAGDINTGFWNGRDTNTGFGNSGLSNFGFGNSGVN
Mb1166c|M.bovis_AF2122/97           ---FFNFGSG-------------------------NTANTNFGSGNLGNL
Rv1135c|M.tuberculosis_H37Rv        ---FFNFGSG-------------------------NTANTNFGSGNLGNL
MAV_4704|M.avium_104                ---FLAPRAPQ---------------------------------------
MLBr_01182|M.leprae_Br4923          -----------------------------------------------MEA
TH_3113|M.thermoresistible__bu      ----------------------------------------------LLPG
Mflv_5091|M.gilvum_PYR-GCK          VGGIGGAGSTGAVGGVGGKG----IQGGQG-------------LQGGKGG
Mvan_1264|M.vanbaalenii_PYR-1       VGGVGGVGATGGAGGVGGKG----IQGGQG-------------LQGGQGG
MSMEG_0868|M.smegmatis_MC2_155      ISAGGDGGSATGADSLGGRGGTSWVQAGYGPTTGGKASGTAKAGHGGKAS
MAB_4284c|M.abscessus_ATCC_199      ----GNAGLAGNAGLAGNAG------------------------LAGNAG
                                                                                      

MMAR_4320|M.marinum_M               NVGAGNGGSSNVGLGN------------------AGLLNTGSFNSGNFNT
MUL_0965|M.ulcerans_Agy99           NVGAGNGGSSNVGLGN------------------AGLLNTGSFNSGKFNT
Mb1166c|M.bovis_AF2122/97           NLGSGNDGNGNFGLGN------------------IGDGNRGSGNVGSFNF
Rv1135c|M.tuberculosis_H37Rv        NLGSGNDGNGNFGLGN------------------IGDGNRGSGNVGSFNF
MAV_4704|M.avium_104                --------------------------------------------------
MLBr_01182|M.leprae_Br4923          TVVPQVDQQVNVDVAT------------------PQTAVPDSSSAAAPQL
TH_3113|M.thermoresistible__bu      ATGDGPPMATIMSFLL------------------MGLSNPAYLFPVLVYL
Mflv_5091|M.gilvum_PYR-GCK          DGGAGGKGGDADSMGS------------------AGATGGKGGNGGNGGR
Mvan_1264|M.vanbaalenii_PYR-1       DGGTGGTGGDATSMGE------------------AGATGGKGGNGGNGGR
MSMEG_0868|M.smegmatis_MC2_155      DGGKGGNGGDALVMAAGATGVATGNTAIGGNGGAASANGAVGGNGGFTNI
MAB_4284c|M.abscessus_ATCC_199      LAGNAGLAGNAGLAGN-------------------AGLAGNAGLAGNAGL
                                                                                      

MMAR_4320|M.marinum_M               GDFNS----------------GSMNTGYFNSSGHNTGLGNSGFTNTGFFN
MUL_0965|M.ulcerans_Agy99           GDFNS----------------GSMNTGYFNSSGHNTGLGNSGFTNTGFFN
Mb1166c|M.bovis_AF2122/97           GTANA----------------GSFNVGSAN--------------------
Rv1135c|M.tuberculosis_H37Rv        GTANA----------------GSFNVGSAN--------------------
MAV_4704|M.avium_104                --------------------------------------------------
MLBr_01182|M.leprae_Br4923          WGGFA----------------QHLSP------------------------
TH_3113|M.thermoresistible__bu      LFTGV----------------VHTTVAVSG--------------------
Mflv_5091|M.gilvum_PYR-GCK          GGLFG---------------KGGNAGNGAD--------------------
Mvan_1264|M.vanbaalenii_PYR-1       GSLFG---------------RGGNAGNGGN--------------------
MSMEG_0868|M.smegmatis_MC2_155      AAIHGSITDSSATSGHGGAAQGGNGGNGGNGWVQAYDPNGPAGTTIDKGK
MAB_4284c|M.abscessus_ATCC_199      AGNAG---------------LAGNAGLAGN--------------------
                                                                                      

MMAR_4320|M.marinum_M               SGDLNTGMGSPEDQSVANSGFRNAGSGNSGFNNTGSFSSGFFNSTNSNSG
MUL_0965|M.ulcerans_Agy99           SGDLNTGMGSPEDQSVANSGFRNAGSGNSGFNNTGSFSSGFFNSTNSNSE
Mb1166c|M.bovis_AF2122/97           -------HGSP---------------------------------------
Rv1135c|M.tuberculosis_H37Rv        -------HGSP---------------------------------------
MAV_4704|M.avium_104                --------------------------------------------------
MLBr_01182|M.leprae_Br4923          --------------------------------------------------
TH_3113|M.thermoresistible__bu      --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK          --GGTGGAGGAGGTGG-TGGAGGTGG-----------------TGGTGGI
Mvan_1264|M.vanbaalenii_PYR-1       --GGTGGNGGNGGTGG-TGGNGGTGG-----------------TGGTGGI
MSMEG_0868|M.smegmatis_MC2_155      AAGGNGGDGGFNGTGGATGGRGGDGAGASVWKANGQHSTGQTDTGGNGGR
MAB_4284c|M.abscessus_ATCC_199      -----------------------------------------------AGL
                                                                                      

MMAR_4320|M.marinum_M               FLNAGGTVNSGINNSGNTNAGIGNLGDDNFGLFNNGTFNTGAGNSSGGAV
MUL_0965|M.ulcerans_Agy99           FLNAGGTVNSGINNSGNTNAGIGNLGDDNFGLFNNGTFNTGAGNSSGGAV
Mb1166c|M.bovis_AF2122/97           --------NVGFANLGNNNLGIANLGNN----------------------
Rv1135c|M.tuberculosis_H37Rv        --------NVGFANLGNNNLGIANLGNN----------------------
MAV_4704|M.avium_104                --------------------------------------------------
MLBr_01182|M.leprae_Br4923          --------------------------------------------------
TH_3113|M.thermoresistible__bu      --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK          GGAGSTGGTGGTGGTGGTGGTGGTG-GTGGTGGTGGTGGKGGTGGTGGAG
Mvan_1264|M.vanbaalenii_PYR-1       GGAGSTGGTGGTGGTGGTGGTGGTG-GTGGTGGTGGTGGKGGTGGTGGDG
MSMEG_0868|M.smegmatis_MC2_155      GGDGGTFVNAGANGNGGAGGAGGVSEGEGGTGGHGGDGGRGGDGALGGNG
MAB_4284c|M.abscessus_ATCC_199      AGNAGLAGNAGLAGNAGLAGNAGLAGNAGLAGNAGLAGNAGLAGNAGLAG
                                                                                      

MMAR_4320|M.marinum_M               FPYTSGLFNSGNGSSGVFNAGDEQSGFFGTSGLVLTGTDGLAAATTSGLP
MUL_0965|M.ulcerans_Agy99           FPYTSGLFNSGNGSSGVFNAGDEQSGFFGTSGLVLTGTDGLAATTTSGLP
Mb1166c|M.bovis_AF2122/97           --------------------------------------------------
Rv1135c|M.tuberculosis_H37Rv        --------------------------------------------------
MAV_4704|M.avium_104                --------------------------------------------------
MLBr_01182|M.leprae_Br4923          --------------------------------------------------
TH_3113|M.thermoresistible__bu      --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK          GTG----GDGGTGGTGGTGGTG---------GTGGTGGTGGAG-------
Mvan_1264|M.vanbaalenii_PYR-1       GTG----GTGGTGGTGGTGGTG---------GTGGTGGTGGAG-------
MSMEG_0868|M.smegmatis_MC2_155      GTGGVGLGNGGKGGNGGNGGNGGTYVDPSHTGAGGNGGNGGAGRIRVNNG
MAB_4284c|M.abscessus_ATCC_199      NAG-----------------------------------------------
                                                                                      

MMAR_4320|M.marinum_M               ALDLPAPNLGIGNAGVGNLGLGNIGDYNLGSGNTGDANFGFGNIGQANLG
MUL_0965|M.ulcerans_Agy99           ALDLPAPNLGIGNAGVGNLGLGNIGDYNLGSGNTGDA-------------
Mb1166c|M.bovis_AF2122/97           -------NLGIANLGNNNIGIGLTGDNMIG--------------------
Rv1135c|M.tuberculosis_H37Rv        -------NLGIANLGNNNIGIGLTGDNMIG--------------------
MAV_4704|M.avium_104                --------------------------------------------------
MLBr_01182|M.leprae_Br4923          --------------------------------------------------
TH_3113|M.thermoresistible__bu      --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK          ----DGTGGTGGTGG----TGGQGGQGGQGG-----------------TG
Mvan_1264|M.vanbaalenii_PYR-1       ----DGLGGTGGTGG----TGGFGGQGGQGG-----------------TG
MSMEG_0868|M.smegmatis_MC2_155      TATGTATGGNGGNGGNGDADGHRGGKGGDGGEALIRATVIGSNASGTATG
MAB_4284c|M.abscessus_ATCC_199      ------LAGNAAVAGNAAVAGNAAVAGNAAVG------------------
                                                                                      

MMAR_4320|M.marinum_M               SGNAGNTNLGSGNTGSTNFGSGNIGALNLGSGNHGDANLGFGNFGNGNIG
MUL_0965|M.ulcerans_Agy99           -----------------NFGSGNIGALNLGSGNHGDANLGFG--------
Mb1166c|M.bovis_AF2122/97           -----------------------IGALNSGIG-----NLGFG--------
Rv1135c|M.tuberculosis_H37Rv        -----------------------IGALNSGIG-----NLGFG--------
MAV_4704|M.avium_104                --------------------------------------------------
MLBr_01182|M.leprae_Br4923          --------------------------------------------------
TH_3113|M.thermoresistible__bu      --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK          GTGGQGG-LGGGGGTG-----------------------GQGGTGGTGGQ
Mvan_1264|M.vanbaalenii_PYR-1       GTGGQGG-LGGVGGTG-----------------------GTGGTGGTGGQ
MSMEG_0868|M.smegmatis_MC2_155      GDGGNGGTLGATNGTGGAATIVAYNVVQANPQASGTATDGHGGSGINGGH
MAB_4284c|M.abscessus_ATCC_199      --------------------------------------------------
                                                                                      

MMAR_4320|M.marinum_M               SGNHGAGNFGSGNTGSRNLGSGNAGSTNFGSGNHGNSNVGLGNFGNNNLG
MUL_0965|M.ulcerans_Agy99           --------------------------------------------------
Mb1166c|M.bovis_AF2122/97           --------------------------------------------------
Rv1135c|M.tuberculosis_H37Rv        --------------------------------------------------
MAV_4704|M.avium_104                --------------------------------------------------
MLBr_01182|M.leprae_Br4923          --------------------------------------------------
TH_3113|M.thermoresistible__bu      --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK          GGTGGTGGTGGTG-------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1       GGTGGTGGTGGTG-------------------------------------
MSMEG_0868|M.smegmatis_MC2_155      GGNGGQGTIEANGPSAVASGI-----------------------------
MAB_4284c|M.abscessus_ATCC_199      --------------------------------------------------
                                                                                      

MMAR_4320|M.marinum_M               LGNNGSNNIGFGLTGDNLVGIGALNSGAGNLGFGNTGDNNIGLFNSGDNN
MUL_0965|M.ulcerans_Agy99           ----------------------------------NTGDNNIGLFNSGDNN
Mb1166c|M.bovis_AF2122/97           ----------------------------------NSGNNNIGLFNSGNNN
Rv1135c|M.tuberculosis_H37Rv        ----------------------------------NSGNNNIGLFNSGNNN
MAV_4704|M.avium_104                --------------------------------------------------
MLBr_01182|M.leprae_Br4923          ------------------------------------INDTLSMINN----
TH_3113|M.thermoresistible__bu      -----------------------------------MLAQLVPLMPALLPV
Mflv_5091|M.gilvum_PYR-GCK          ---------------------------GTGGAGGDGGLGGLGGFGGSGGT
Mvan_1264|M.vanbaalenii_PYR-1       ---------------------------GTGGAGGDGGLGGLGGFGGVGGT
MSMEG_0868|M.smegmatis_MC2_155      ---------------------------GAGGNGGDGIDGGLGGNGGDGVV
MAB_4284c|M.abscessus_ATCC_199      ------------------------------GVLNTGVSGAIGGSSHVGGA
                                                                                      

MMAR_4320|M.marinum_M               VGFFNSGDGNFGLANSGDTNTGLWNAGSTNTGFGNAGSADFGFGNAGDRN
MUL_0965|M.ulcerans_Agy99           VGFFNSGGANFGLANSGDTNTGLWNAGSTNTGFGNAGSADFGFGNAGDRN
Mb1166c|M.bovis_AF2122/97           IGFFNSGDSNFGFFNSGDTNTGFGNAGFTNTGFGNAGSGNFGFGNAGNNN
Rv1135c|M.tuberculosis_H37Rv        IGFFNSGDSNFGFFNSGDTNTGFGNAGFTNTGFGNAGSGNFGFGNAGNNN
MAV_4704|M.avium_104                --------------------------------------------------
MLBr_01182|M.leprae_Br4923          ----HAGMANAGLSLVNGMGSAMKSLAPTTTKAAESAFKAMGSAVQSTGR
TH_3113|M.thermoresistible__bu      AVAALGGLAGVWAGLSGLAGLAGLTAVPAADGGASAAPVPAGGPSLPSGS
Mflv_5091|M.gilvum_PYR-GCK          GGQGGLGGPGGSTGGAGGAGG--QAGTAGKGGLFG----GSGSAGKAGAT
Mvan_1264|M.vanbaalenii_PYR-1       GGQGGQGGPGGSTGGAGGAGG--QAGVAGKGGLFG----GSGSAGTAGVT
MSMEG_0868|M.smegmatis_MC2_155      NTTANAANPGSATGTATGGDGGKATGTASQGGNGGPSWVQSGYGSTLGGN
MAB_4284c|M.abscessus_ATCC_199      INESLGGSGSVGGSTAVGGGAHTGVGGGVSTGVGVGSHVGGGISESLGGS
                                                                                      

MMAR_4320|M.marinum_M               MGFGNAGAANMGAGNSGSYNTG-----------SFNSGTLNTGDFNGGDH
MUL_0965|M.ulcerans_Agy99           MGFGNAGAANMGAGNSGSYNTG-----------SFNSGTLNTGDFNGGDH
Mb1166c|M.bovis_AF2122/97           FGFGNSGFENMGVGNSGAYNTG-----------SFNSGTLNTGDLNSGDF
Rv1135c|M.tuberculosis_H37Rv        FGFGNSGFENMGVGNSGAYNTG-----------SFNSGTLNTGDLNSGDF
MAV_4704|M.avium_104                --------------------------------------------------
MLBr_01182|M.leprae_Br4923          GLLGSSSGGHVTAQLGRAASIG-----------SLRVPQTWTTASQPVTA
TH_3113|M.thermoresistible__bu      SAPPAPTGSAAPTTGTAPGGAG-----------SPPPAGHSVPPAPHSAP
Mflv_5091|M.gilvum_PYR-GCK          GAAGASGGKGAQGATGAQGATG------AQGATG-ATGAAGKAGATGAAG
Mvan_1264|M.vanbaalenii_PYR-1       GASGASGGKGAQGATGAQGATG------AQGATG-ATGASGAQGSAGSAG
MSMEG_0868|M.smegmatis_MC2_155      ATGTATAGKGGEASNGGVAGNGGNALVMAAGTTGVATGNTATGGDGGAAT
MAB_4284c|M.abscessus_ATCC_199      GSVGGSTAVGGGAHTGVGGGVS----------TGVGVGSHVGGGISESLG
                                                                                      

MMAR_4320|M.marinum_M               NTGWGNSGN-------------------TNTGGINSGDLNTGFGSSADQA
MUL_0965|M.ulcerans_Agy99           NTGWGNSGN-------------------TNTGGINSGDLNTGFGSSADQA
Mb1166c|M.bovis_AF2122/97           NTGWANSGD-------------------INTGGFHSGDLNTGFGSPVDQP
Rv1135c|M.tuberculosis_H37Rv        NTGWANSGD-------------------INTGGFHSGDLNTGFGSPVDQP
MAV_4704|M.avium_104                --------------------------------------------------
MLBr_01182|M.leprae_Br4923          ATRALSPAR-------------------VAVATESESAPLLGGGLPMAPM
TH_3113|M.thermoresistible__bu      PVGTSGPPY-------------------LIAAQPAPGVARRSAGARRAAS
Mflv_5091|M.gilvum_PYR-GCK          AAGAAGSAG-----------TTGAQGSAGTNGA-NGANGSQGAAGKAGAT
Mvan_1264|M.vanbaalenii_PYR-1       SAGVAGSAG-----------TTGAQGSAGTNGA-NGANGSQGAAGKAGAT
MSMEG_0868|M.smegmatis_MC2_155      TAGATGGAGGFSNIAAIHGAITDSTAISGHGGAGNGGNGGKGADGWVQAY
MAB_4284c|M.abscessus_ATCC_199      GSGSVGGST--------------AVGGGAHTGVGGGVNTGVGVGSHVGGG
                                                                                      

MMAR_4320|M.marinum_M               VTNSGFG---------NNGSGNSGFNNTGDTNSGFHNANTSALFSGHSGL
MUL_0965|M.ulcerans_Agy99           VTNSGFG---------NNGSGNSGFNNTGDTNSGFHNANTSALFSGHSGL
Mb1166c|M.bovis_AF2122/97           VMNSGFG---------NIGTGNSGFNNSGDANSGFQNTNTGAFFIGHSGL
Rv1135c|M.tuberculosis_H37Rv        VMNSGFG---------NIGTGNSGFNNSGDANSGFQNTNTGAFFIGHSGL
MAV_4704|M.avium_104                --------------------------------------------------
MLBr_01182|M.leprae_Br4923          VPGGGSG---------TGG-------------------------------
TH_3113|M.thermoresistible__bu      IVEPAGS---------AAAAAAARESAPIRRRRGQKDGLHG---------
Mflv_5091|M.gilvum_PYR-GCK          GTTGATG--------AAGEDGDAGSGGSG-INGGAGGAGG----------
Mvan_1264|M.vanbaalenii_PYR-1       GTTGATG--------AAGDAGDPGSEAVD-INGGAGGAGG----------
MSMEG_0868|M.smegmatis_MC2_155      DPAGPVGSKIANSSAVAGNGGDGGVNGTGGASGGDGGNGGNTSVWKSGGQ
MAB_4284c|M.abscessus_ATCC_199      ISESLGG---------SGSVGGSTAVGGGAHTSAINDALGGS--------
                                                                                      

MMAR_4320|M.marinum_M               LNAGGSQSVGINNTGS-FNTGLFNTGFRTAGIANSATNGLLTATSGVANS
MUL_0965|M.ulcerans_Agy99           LNAGGSQSVGINNTGS-FNTVLFNTGFRTAGIANSATNGLLTATSGVANS
Mb1166c|M.bovis_AF2122/97           LNSGGGQHVGISNSGTGFNTGLFNTGFNNTGIGNSATNAAFTTTSGVANS
Rv1135c|M.tuberculosis_H37Rv        LNSGGGQHVGISNSGTGFNTGLFNTGFNNTGIGNSATNAAFTTTSGVANS
MAV_4704|M.avium_104                --------------------------------------------------
MLBr_01182|M.leprae_Br4923          ------------------------------------VNTALRLQPRAFVM
TH_3113|M.thermoresistible__bu      HRHEHQQPASMSAATAPSAAGIRVLGGAGRISRTRGSVPHAEITPGDPTE
Mflv_5091|M.gilvum_PYR-GCK          -AGGEGGEGGDGGKGGAGAE--------GGAGGGGGAGGSGAGGAG--GA
Mvan_1264|M.vanbaalenii_PYR-1       -AGGEGGEGGAGGAGGDGSE--------GGAGGSGGAGGSGTGGAG--GA
MSMEG_0868|M.smegmatis_MC2_155      TADGEHNTGGNGGNGGDGSEPGPGGNGAGGAGGNGGTGGTTAGGSGNGGN
MAB_4284c|M.abscessus_ATCC_199      GSVGGSTAVGGGAHTSAINESMNSSINASHSSSMNESFGSSMGSHGAAGT
                                                                                      

MMAR_4320|M.marinum_M               GNNSSGGFNANPDQSGFFN-------
MUL_0965|M.ulcerans_Agy99           GNNSSGGFNANPDQSGFFN-------
Mb1166c|M.bovis_AF2122/97           GDNSSGGFNAGNDQSGFFDG------
Rv1135c|M.tuberculosis_H37Rv        GDNSSGGFNAGNDQSGFFDG------
MAV_4704|M.avium_104                --------------------------
MLBr_01182|M.leprae_Br4923          PRNPAAG-------------------
TH_3113|M.thermoresistible__bu      PSSPTDRAHRPAEPN-----------
Mflv_5091|M.gilvum_PYR-GCK          GGSGGSGGSGGSGGSGGAAGDSDD--
Mvan_1264|M.vanbaalenii_PYR-1       GGSGGSGGSGGAGGSGGAAGDSD---
MSMEG_0868|M.smegmatis_MC2_155      GGNGGNGGADGTPGTAGTTGANNP--
MAB_4284c|M.abscessus_ATCC_199      GFEAQGHAQGHASETAHTTLPGAEHH