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SERSQYHHGGLRDAILTEAATLVAERGVGAVSVRELARRAGVSHNAYGHHFTDRRGLFTALAAQGFMLLA EALREARGNFLDGARAYVRFAIGHPGHYAVMFDWSLIDRTDSDLAAAHAAASMELARGASLLQDPKAVAD RHGAELAAWSLIHGFSMLWLNGVLPSDPGECTDPIATAERVALMLFET*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_1249 | - | - | 100% (189) | transcriptional regulatory protein |
| M. marinum M | MMAR_4906 | - | 7e-60 | 63.98% (186) | transcriptional regulator |
| M. marinum M | MMAR_4304 | - | 3e-08 | 32.52% (163) | TetR family transcriptional regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0672c | - | 3e-09 | 29.50% (200) | TetR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_1618 | - | 3e-56 | 59.78% (184) | TetR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv0653c | - | 3e-09 | 29.50% (200) | TetR family transcriptional regulator |
| M. leprae Br4923 | MLBr_01733 | - | 3e-05 | 33.70% (92) | putative TetR-family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_0499 | - | 2e-45 | 53.04% (181) | TetR family transcriptional regulator |
| M. avium 104 | MAV_0728 | - | 4e-58 | 61.96% (184) | TetR-family protein transcriptional regulator |
| M. smegmatis MC2 155 | MSMEG_5838 | - | 7e-61 | 62.64% (182) | TetR-family protein transcriptional regulator |
| M. thermoresistible (build 8) | TH_4347 | - | 2e-08 | 31.07% (177) | PUTATIVE transcriptional regulator, TetR family |
| M. ulcerans Agy99 | MUL_2639 | - | 1e-106 | 99.47% (189) | transcriptional regulatory protein |
| M. vanbaalenii PYR-1 | Mvan_5135 | - | 2e-55 | 60.43% (187) | TetR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0672c|M.bovis_AF2122/97 --------------------------------------------------
Rv0653c|M.tuberculosis_H37Rv --------------------------------------------------
TH_4347|M.thermoresistible__bu --------------------------------------------------
MMAR_1249|M.marinum_M ------------------------------------------------MS
MUL_2639|M.ulcerans_Agy99 ------------------------------------------------MS
Mflv_1618|M.gilvum_PYR-GCK -------------------------------------------------M
Mvan_5135|M.vanbaalenii_PYR-1 ------------------------------------------------MS
MSMEG_5838|M.smegmatis_MC2_155 --------------------------------------------------
MAV_0728|M.avium_104 -------------------------------------------------M
MAB_0499|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_01733|M.leprae_Br4923 MTRRSIHTRKPLKWSGCAGQHVRSGKVFDVGRISLSYPSMKPGVKIDARS
Mb0672c|M.bovis_AF2122/97 ---MTSQTGVRDELLHAGVRLLDDHGPDALQTRKVAAAAGTSTMAVYTHF
Rv0653c|M.tuberculosis_H37Rv ---MTSQTGVRDELLHAGVRLLDDHGPDALQTRKVAAAAGTSTMAVYTHF
TH_4347|M.thermoresistible__bu ----VTADDIREKLVDAGVRLLERDGVQALSARNLAAEAGTSTMAVYTRF
MMAR_1249|M.marinum_M ERSQYHHGGLRDAILTEAATLVAERGVGAVSVRELARRAGVSHNAYGHHF
MUL_2639|M.ulcerans_Agy99 ERSQYHHGGLRDAILTEAATLVAERGVGAVSVRELARRAGVSHNAYGHHF
Mflv_1618|M.gilvum_PYR-GCK TRGSYHHGDLKAVILAQAATLVAERGADGVSLRELARAAGVSHAAPAHHF
Mvan_5135|M.vanbaalenii_PYR-1 SRGTYHHGDLRATILARAADLVAERGADGVSLRELARAAGVSHAAPAHHF
MSMEG_5838|M.smegmatis_MC2_155 --MAYHHGDLKAVILQHAATLVAERGADGISLRELARTAGVSHAAPAHHF
MAV_0728|M.avium_104 TRHSYHHGDLPAVILAEAARLVAERGAERVSLRELARCAGVSHAAPAHHF
MAB_0499|M.abscessus_ATCC_1997 --MSYHHGDLRAAILTSAADMVARRGATELSLRELAREAGVSHAAPAHHF
MLBr_01733|M.leprae_Br4923 ERWREHRKKVRGEIVDAAFRALDRLGP-EVSVREIAEEAGTAKPKIYRHF
: :: . : * :. *::* **.: :*
Mb0672c|M.bovis_AF2122/97 GGMRGLIAAIAEEGLRQFDVALT-VPQTA--DPVADLLAIGTAYRRYAIE
Rv0653c|M.tuberculosis_H37Rv GGMRGLIAAIAEEGLRQFDVALT-VPQTA--DPVADLLAIGTAYRRYAIE
TH_4347|M.thermoresistible__bu GGMPGVLEAVAGEIFARFADALTQIPQTG--DPVADFLLMGAAYREYALT
MMAR_1249|M.marinum_M TDRRGLFTALAAQGFMLLAEALR--------EARGNFLDGARAYVRFAIG
MUL_2639|M.ulcerans_Agy99 TDRRGLFTALAAQGFMLLAEALR--------EARGNFLDGARAYVRFAIG
Mflv_1618|M.gilvum_PYR-GCK TDRRGVFTALATQGWRMLAAALG--------ESRPEFLDAALAYVRFAVD
Mvan_5135|M.vanbaalenii_PYR-1 TDRRGLFTALATEGFRSLAEELS--------RARPEFLDAALAYVRFALA
MSMEG_5838|M.smegmatis_MC2_155 TDRRGLFTALATEGYQLLADALK--------DVRGQFIDAAKAYVRFALD
MAV_0728|M.avium_104 TDRRGLFTALATQGFELLTRALA--------DARGDFADAALAYVQFALD
MAB_0499|M.abscessus_ATCC_1997 GDRRGLFTALAADGFTRLADALD--------GAHPDFHAAALAYVEFALA
MLBr_01733|M.leprae_Br4923 TDKSDLFEAIGIRLRDMLWAAIFPAIDLATDSAREIIRRSVDEYVSLVDK
. .:: *:. : : : * .
Mb0672c|M.bovis_AF2122/97 RPHMYRLMFGSTSAHGIN-VPARDVLTLKVAEIEHQHPSFAHVVRAVHRC
Rv0653c|M.tuberculosis_H37Rv RPHMYRLMFGSTSAHGIN-VPARDVLTLKVAEIEHQHPSFAHVVRAVHRC
TH_4347|M.thermoresistible__bu HPQRYLLMFGTATPASIAGSRADLTATGEVSDRTEWAASFEALRTMVRRM
MMAR_1249|M.marinum_M HPGHYAVMFDWSLIDRTD--------SDLAAAHAAASMELARGASLLQDP
MUL_2639|M.ulcerans_Agy99 HPGHYAVMFDWSLIDRTD--------SDLAAAHAAASMELARSASLLQDP
Mflv_1618|M.gilvum_PYR-GCK HPGHYEVMFDRSLVDPDN--------PELVAAQTEAGAELAAGVGTLDDA
Mvan_5135|M.vanbaalenii_PYR-1 NPGHYEVMFDKSLYHADD--------PALVDAETAAGSELAAGVGTLDDP
MSMEG_5838|M.smegmatis_MC2_155 HPGHYAVMFDKSLYDDTD--------PGLVAAASAAGAELNRGVGTLDDP
MAV_0728|M.avium_104 HPGHYQVMFNRSLLDASD--------GGLAAAEGAAGAELSRGVATLRDP
MAB_0499|M.abscessus_ATCC_1997 NPGHYSVMFEPALLDLAD--------GRLAEARDRAAAALDSGIATLTPQ
MLBr_01733|M.leprae_Br4923 HPNVLRVFIQGRFSAQSEAT-----VRTLDEGREITLTMAEMFNNELREM
.* ::: :
Mb0672c|M.bovis_AF2122/97 LLAGRFATALGADDDTAIVATAAQFWSQIHGFVMLELAGFYGDRGAA-VE
Rv0653c|M.tuberculosis_H37Rv LLAGRFATALGADDDTAIVATAAQFWSQIHGFVMLELAGFYGDRGAA-VE
TH_4347|M.thermoresistible__bu IAAGRIR-------DDGEAAIAGRLWSLIHGEVMLELAGFFGAEGHG-LT
MMAR_1249|M.marinum_M KAV------------ADRHGAELAAWSLIHGFSMLWLNGVLPSDPGE-CT
MUL_2639|M.ulcerans_Agy99 KAV------------ADRHGAELAAWSLIHGFSMLWLNGVLPSDPGE-CT
Mflv_1618|M.gilvum_PYR-GCK RAR------------EDPQAAGLAAWSLVHGFAMLWLNEAIDTDA-----
Mvan_5135|M.vanbaalenii_PYR-1 RAK------------DDPQAAALAAWSLVHGFALLWLNGAVNTTG-----
MSMEG_5838|M.smegmatis_MC2_155 KAK------------DDPAGAALAAWSMVHGFSLLWLNDAIDTDR-----
MAV_0728|M.avium_104 HAR------------ADPGGAELAAWSLVHGFATLWLNDAVDAAVR--AA
MAB_0499|M.abscessus_ATCC_1997 QTS------------ADRITAARAAWSLVHGFVSLWTTGALADSRD--DA
MLBr_01733|M.leprae_Br4923 ELN-----------RAASELAAFAAFGSVASATEWWLGPEPDSPRRMPRE
:. : .
Mb0672c|M.bovis_AF2122/97 PVLAAMTVNLLVALGDSPERAQCSLRAEQTQKNTLGRAT---
Rv0653c|M.tuberculosis_H37Rv PVLAAMTVNLLVALGDSPERAQCSLRAEQTQKNTLGRAT---
TH_4347|M.thermoresistible__bu KILTPMTVDMLVGLGDDRARVEASL---TTAAEAHGR-----
MMAR_1249|M.marinum_M DPIATAERVALMLFET--------------------------
MUL_2639|M.ulcerans_Agy99 DPIATAERVALMLFET--------------------------
Mflv_1618|M.gilvum_PYR-GCK DAVVTARRVARMLFTPGPVGDAGRG-----------------
Mvan_5135|M.vanbaalenii_PYR-1 DPMATVRRVAGMLFGGEPVTCPT-------------------
MSMEG_5838|M.smegmatis_MC2_155 DPIATVERLGAILFDG--------------------------
MAV_0728|M.avium_104 DPMDTVRRIATMLFAG--------------------------
MAB_0499|M.abscessus_ATCC_1997 DPLRIASQIAYVLFPEAG------------------------
MLBr_01733|M.leprae_Br4923 QFVAHLTIIMMAVIVGTAETLGISMNPDRPIHDAVPLDRSAS
: :