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MTPADEFAQQKVALTGVSETALLTLNARAAEARRRDPIIEDPMAVRLVDSIDFDFAKFGPTRQDIALRAL AFDTRALAYLNKHPSATVVALAEGLQTSFWRLDSALPGKKFRWLTVDLPPIIDIRKRLLPNSPRVSVCAQ SALDYGWMDSVDTSGGVFITAEGLLMYLEPDQALDLIAQCAKRFPGAQMLFDLPPRWFSLFTRLGMRTSI RYKIPPMPFSLSVAQAADLVNTIPGIRAVRDVQLPAGRGLMFNAALSTVYRLPALDSLRPCLTLLEFG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_4300 | omt_2 | - | 100% (278) | O-methyltransferase Omt_2 |
| M. marinum M | MMAR_2733 | omt | 3e-91 | 61.13% (265) | O-methyltransferase Omt |
| M. marinum M | MMAR_0262 | omt_1 | 2e-72 | 54.14% (266) | O-methyltransferase Omt_1 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1184c | omt | 1e-122 | 78.52% (270) | O-methyltransferase |
| M. gilvum PYR-GCK | Mflv_5259 | - | 3e-95 | 63.53% (266) | O-methyltransferase domain-containing protein |
| M. tuberculosis H37Rv | Rv1153c | omt | 1e-122 | 78.89% (270) | O-methyltransferase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0668c | - | 2e-78 | 56.23% (265) | O-methyltransferase OmT |
| M. avium 104 | MAV_2991 | - | 2e-25 | 33.80% (213) | tetracenomycin polyketide synthesis O-methyltransferase TcmP |
| M. smegmatis MC2 155 | MSMEG_5173 | - | 4e-99 | 64.36% (275) | O-methyltransferase, putative |
| M. thermoresistible (build 8) | TH_0460 | omt | 1e-101 | 66.91% (269) | PROBABLE O-METHYLTRANSFERASE OMT |
| M. ulcerans Agy99 | MUL_3020 | omt | 4e-88 | 59.85% (264) | O-methyltransferase Omt |
| M. vanbaalenii PYR-1 | Mvan_0979 | - | 4e-95 | 61.80% (267) | O-methyltransferase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_5259|M.gilvum_PYR-GCK ------------MLAGVSETALLTLNGRAYQARHPNAILDDPMAIRVVDS
Mvan_0979|M.vanbaalenii_PYR-1 -MDQDGKIDAG-ALAGVSETALLTLNGRAYQARHPNAIIDDPMAIRLVDA
MUL_3020|M.ulcerans_Agy99 MGHSDNNVNAG-MLGGVSETALLTLNGRAHQAAKPNPIIDDPMAIKLVES
Mb1184c|M.bovis_AF2122/97 MS-AHKPAKQRVALTGVSETALLTLNARAAEARRRDTIIDDPMAVALVES
Rv1153c|M.tuberculosis_H37Rv MS-AHKPAKQRVALTGVSETALLTLNARAAEARRRDAIIDDPMAVALVES
MMAR_4300|M.marinum_M MTPADEFAQQKVALTGVSETALLTLNARAAEARRRDPIIEDPMAVRLVDS
MSMEG_5173|M.smegmatis_MC2_155 MT-TDATARTRVSLTGVSETALLTLQVRANEARRPDGLIKDPMAVQLVDS
TH_0460|M.thermoresistible__bu VS-SGPLAKP--ELTGVSETALLTLLVRATEARRPDGIIDDPMAVRLVDS
MAB_0668c|M.abscessus_ATCC_199 -----MSGIDVRHLDGVSETALLTLHQRATEAARTDGILDDPMAISLHAS
MAV_2991|M.avium_104 MTATEKVDFSSVAWGSVEWTNLVTLYLRACESRSRQPILGDTAAAEAVDR
.*. * *:** ** :: : :: *. *
Mflv_5259|M.gilvum_PYR-GCK IDFDFDKFGRRKG-----QEMALRSLAFDRAATAYLAKHPKATVVALAEG
Mvan_0979|M.vanbaalenii_PYR-1 IDFDFDKFGRRKG-----QEMALRSLAFDRAATRYLSRHPAATVVALAEG
MUL_3020|M.ulcerans_Agy99 NDFDFEKFGRR-G-----QEMALRSLAVDRCEIAYLTKHPGATVVAHAEG
Mb1184c|M.bovis_AF2122/97 IDFGFAKFGPTG------QGFALRARAFDMAAQHYLDQHPAATVVALAEG
Rv1153c|M.tuberculosis_H37Rv IDFDFAKFGPTG------QGFALRARAFDMAAQHYLDQHPAATVVALAEG
MMAR_4300|M.marinum_M IDFDFAKFGPTR------QDIALRALAFDTRALAYLNKHPSATVVALAEG
MSMEG_5173|M.smegmatis_MC2_155 IDFDFAKFGHSHR-----QDMALRSLIFDRATSDYLRDHPKATVVALAEG
TH_0460|M.thermoresistible__bu IDFDFAKFGPSRR-----QDMALRAKAFDTATRRYLRAHPKATVVALAEG
MAB_0668c|M.abscessus_ATCC_199 VDYDFAHFGRTH------QATALRALIFDKATREYLDYHPCATVVALAEG
MAV_2991|M.avium_104 IRYDFKRIHRMSLPASNQYLVALRAVQFDDWCAEFLARHPDAVVLHLGCG
:.* :: ***: .* :* ** *.*: . *
Mflv_5259|M.gilvum_PYR-GCK LQTSFWRLDAALPTAEFRWLTVDFEPIIELRRRLLPESARITTLAQSALD
Mvan_0979|M.vanbaalenii_PYR-1 LQTSFWRLDAAIPDSRFRWVSIDLEPVIALRRRLLPDSPRITTLAQSALD
MUL_3020|M.ulcerans_Agy99 FQTGFWRVSNALPDTQFRWVSLDLEPVMELRRRLLPDSARVTNLAQSALD
Mb1184c|M.bovis_AF2122/97 LQTSFWRLDVAIPGGQFRWLTVDLPPIVDLRTRLLPSSPRVSVCAQSALD
Rv1153c|M.tuberculosis_H37Rv LQTSFWRLDVAIPGGQFRWLTVDLPPIVDLRTRLLPSSPRVSVCAQSALD
MMAR_4300|M.marinum_M LQTSFWRLDSALPGKKFRWLTVDLPPIIDIRKRLLPNSPRVSVCAQSALD
MSMEG_5173|M.smegmatis_MC2_155 LQTSFYRLNEAGVGDQFCWLTVDLPPMVEIRNKLLPPSDRVRTCAQSALD
TH_0460|M.thermoresistible__bu LQTSFFRLNAADVGDEFRWVTVDLAPVIELRRQLLPADDRVTMLAQSALD
MAB_0668c|M.abscessus_ATCC_199 LQTSFWRVD----NGRLTWLSVDLEPIVRLRQRLLPRSERLSHCAQSALD
MAV_2991|M.avium_104 LDGRAFRVSVP---PSLSWFDVDQPSVIGLRRRLYDDTENYRMIGSSVTE
:: :*:. : *. :* .:: :* :* . ..*. :
Mflv_5259|M.gilvum_PYR-GCK YSWMDAVDTTHGVFITAEGLLMYLQPEESMGLITECAARFPGAQMIFDLP
Mvan_0979|M.vanbaalenii_PYR-1 YSWMDAVDTTDGVFITAEGLLMYLQPDEAMDLITACASRFPGGQMIFDLP
MUL_3020|M.ulcerans_Agy99 YTWMDKVDSCAAVFITAEGLLMYPQPNQAMELISQCAKRFAGGQMFFDLP
Mb1184c|M.bovis_AF2122/97 YSWMDSVDPAGGVFITAEGLLMYLQPEQALGLIAQCAQTFPGGQMLFDLP
Rv1153c|M.tuberculosis_H37Rv YSWMDSVDPAGGVFITAEGLLMYLQPEQALGLIAQCAQTFPGGQMLFDLP
MMAR_4300|M.marinum_M YGWMDSVDTSGGVFITAEGLLMYLEPDQALDLIAQCAKRFPGAQMLFDLP
MSMEG_5173|M.smegmatis_MC2_155 YSWMDQVDDSEGVFITAEGLLMYLQPEESMGLIKECARRFPGGQMIFDLP
TH_0460|M.thermoresistible__bu YSWMDRIDTSEGVFITAEGLLMYLQPDEAMGLIRECARRFPGGQMMFDLP
MAB_0668c|M.abscessus_ATCC_199 YSWMDRVDDSAGVLITAEGLFQYLERDLVFDLISVCAQRFPGGRLIFDSV
MAV_2991|M.avium_104 LQWLDEVPAGRPTLMVAEGLLMYLREDEVRRLLQRLIDRFPGGEMHFDTL
*:* : .::.****: * . : *: *.*..: **
Mflv_5259|M.gilvum_PYR-GCK PVMVKKFAPKGVRSSSRYRVPPMPFSLSAAELADLVHTVPGVRAVHDLPM
Mvan_0979|M.vanbaalenii_PYR-1 PTMVKKIAPKGMRSSARYRVPPMPFSLSPAQLAELVHTVPGVTAVHDLPM
MUL_3020|M.ulcerans_Agy99 PTIVKRVAPKGMRASRRYRVPPMPFSLSVNQLARLVDTVPGIRAVHDVPM
Mb1184c|M.bovis_AF2122/97 PRWFAGWSRLGLRTSLRYKVPRMPFSMSVAQAADLVNKVPGVVAVRDLRV
Rv1153c|M.tuberculosis_H37Rv PRWFAGWSRLGLRTSLRYKVPRMPFSMSVAQAADLVNKVPGVVAVRDLRV
MMAR_4300|M.marinum_M PRWFSLFTRLGMRTSIRYKIPPMPFSLSVAQAADLVNTIPGIRAVRDVQL
MSMEG_5173|M.smegmatis_MC2_155 PSWFAAWARKGMRTSRRYRVPPMPFSLSPAEVADLVNTVPGVRVVHDLPF
TH_0460|M.thermoresistible__bu PSFFAWLTRRGFRTSLRYKVPPMPFTLSPEQAADLVNTVPGVQAVHDVPI
MAB_0668c|M.abscessus_ATCC_199 PKFLSTHSQRGIRLSEQYVVPPMPFSFTANQYDELR-AIPGIRSVRELRM
MAV_2991|M.avium_104 SALAPLLSKVFTRG---------IITWGIRDARRIADWNPRLRFLEQSPA
. : * :: : : * : :.:
Mflv_5259|M.gilvum_PYR-GCK PQGRGFFFEKVFPAFWGLKATKNYRGAYTLLEFG-------
Mvan_0979|M.vanbaalenii_PYR-1 PRGRGFLFERVFPAFWQFKPTRNYRGAYTLLEFG-------
MUL_3020|M.ulcerans_Agy99 PEGRGLFFRTLYPALWRFPPIKPFRGAYVLLEFD-------
Mb1184c|M.bovis_AF2122/97 PPGRGLWVNMALSTVYRLPVFDPLRPCLTLLEFSRPARG--
Rv1153c|M.tuberculosis_H37Rv PPGRGLWVNMALSTVYRLPVFDPLRPCLTLLEFSRPARG--
MMAR_4300|M.marinum_M PAGRGLMFNAALSTVYRLPALDSLRPCLTLLEFG-------
MSMEG_5173|M.smegmatis_MC2_155 PPARGKFMRTVVWGVQRLPLFDPIRPVMALLEFG-------
TH_0460|M.thermoresistible__bu PRGRGVLVNTLIWAAQRTPLFDNVRGTYTLLEFGPPNSAST
MAB_0668c|M.abscessus_ATCC_199 PAGRGKVLRWAAPLLYALPGLDRWRAPHTVVEFG-------
MAV_2991|M.avium_104 LAGYQRIPSTVVRSIYRLTWLTGGRGYDVLNRFEY------
. * .: .*