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MPVIDARHLDGISETALLTLHQRATEAARPDAIIDDPMAIALRNDIDYPYHHFGRTHQATALRALAFDNS TRDFLRTHPGATVVALAEGLQTSFWRLDNGELNWLSVDLAPIVRLREQLLPACDRLRYCAQSAFDYSWME QVDDTNGVLITAEGLFQYLRRDVVFELIAACAKRFPHGQLVFDSIPWLLSVYSRRRGFRLSEHYTAPPMP FWFTADHYDELRAIPGVRAVRELPAPAGRGRFLRWALPVAYRLPGLGRLRAPVTLVEFG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_0262 | omt_1 | - | 100% (269) | O-methyltransferase Omt_1 |
| M. marinum M | MMAR_4300 | omt_2 | 2e-72 | 54.14% (266) | O-methyltransferase Omt_2 |
| M. marinum M | MMAR_2733 | omt | 7e-66 | 48.15% (270) | O-methyltransferase Omt |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1184c | omt | 3e-69 | 53.96% (265) | O-methyltransferase |
| M. gilvum PYR-GCK | Mflv_2136 | - | 1e-66 | 52.04% (269) | O-methyltransferase domain-containing protein |
| M. tuberculosis H37Rv | Rv1153c | omt | 9e-70 | 54.34% (265) | O-methyltransferase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1292c | - | 1e-114 | 72.49% (269) | O-methyltransferase OMT |
| M. avium 104 | MAV_2991 | - | 1e-19 | 29.72% (249) | tetracenomycin polyketide synthesis O-methyltransferase TcmP |
| M. smegmatis MC2 155 | MSMEG_5173 | - | 9e-71 | 52.06% (267) | O-methyltransferase, putative |
| M. thermoresistible (build 8) | TH_0460 | omt | 3e-70 | 52.81% (267) | PROBABLE O-METHYLTRANSFERASE OMT |
| M. ulcerans Agy99 | MUL_4852 | omt_1 | 1e-155 | 98.14% (269) | O-methyltransferase Omt_1 |
| M. vanbaalenii PYR-1 | Mvan_0979 | - | 4e-67 | 50.37% (272) | O-methyltransferase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_0262|M.marinum_M -----MPVIDARHLDGISETALLTLHQRATEAARPDAIIDDPMAIALRND
MUL_4852|M.ulcerans_Agy99 -----MPVIDARHLDDISETALLTLHQRATEAARPDAIIDDPMAIALRND
MAB_1292c|M.abscessus_ATCC_199 --MAYMAAIDARHLDGVSETALITLNQRATEANRPDGVLEDPMAIVLRDS
Mb1184c|M.bovis_AF2122/97 -MSAHKPAKQRVALTGVSETALLTLNARAAEARRRDTIIDDPMAVALVES
Rv1153c|M.tuberculosis_H37Rv -MSAHKPAKQRVALTGVSETALLTLNARAAEARRRDAIIDDPMAVALVES
Mflv_2136|M.gilvum_PYR-GCK ---MSPTDKHSADLTGVSETALMTLLVRATEARRPDSLIDDPMAVKLVDS
MSMEG_5173|M.smegmatis_MC2_155 -MTTDATARTRVSLTGVSETALLTLQVRANEARRPDGLIKDPMAVQLVDS
TH_0460|M.thermoresistible__bu ---VSSGPLAKPELTGVSETALLTLLVRATEARRPDGIIDDPMAVRLVDS
Mvan_0979|M.vanbaalenii_PYR-1 --MDQDGKIDAGALAGVSETALLTLNGRAYQARHPNAIIDDPMAIRLVDA
MAV_2991|M.avium_104 MTATEKVDFSSVAWGSVEWTNLVTLYLRACESRSRQPILGDTAAAEAVDR
.:. * *:** ** :: : :: *. * :
MMAR_0262|M.marinum_M IDYPYHHFG-----RTH-QATALRALAFDNSTRDFLRTHPGATVVALAEG
MUL_4852|M.ulcerans_Agy99 IDYPYHHFG-----RTH-QATALRALAFDNSTRDFLQTRPGATVVALAEG
MAB_1292c|M.abscessus_ATCC_199 LDYDYHHFG-----RTH-QGIALRALTFDTVSNEYLAEHPRATVVALAEG
Mb1184c|M.bovis_AF2122/97 IDFGFAKFG-----PTG-QGFALRARAFDMAAQHYLDQHPAATVVALAEG
Rv1153c|M.tuberculosis_H37Rv IDFDFAKFG-----PTG-QGFALRARAFDMAAQHYLDQHPAATVVALAEG
Mflv_2136|M.gilvum_PYR-GCK LDFDRAKFG-----FVRRQDMAVRALVFDKWTRRYLVDHPRATVVALAEG
MSMEG_5173|M.smegmatis_MC2_155 IDFDFAKFG-----HSHRQDMALRSLIFDRATSDYLRDHPKATVVALAEG
TH_0460|M.thermoresistible__bu IDFDFAKFG-----PSRRQDMALRAKAFDTATRRYLRAHPKATVVALAEG
Mvan_0979|M.vanbaalenii_PYR-1 IDFDFDKFG-----RRKGQEMALRSLAFDRAATRYLSRHPAATVVALAEG
MAV_2991|M.avium_104 IRYDFKRIHRMSLPASNQYLVALRAVQFDDWCAEFLARHPDAVVLHLGCG
: : :: *:*: ** :* :* *.*: *. *
MMAR_0262|M.marinum_M LQTSFWRLD------NGELNWLSVDLAPIVRLREQLLPACDRLRYCAQSA
MUL_4852|M.ulcerans_Agy99 LQTSFWRLD------NGELNWLSVDLAPIVRLREQLLPACDRLRYCAQSA
MAB_1292c|M.abscessus_ATCC_199 LQTSFWRID------NGELNWLSVDLEPIVRLRRQLLPPSDRVRYVAQSA
Mb1184c|M.bovis_AF2122/97 LQTSFWRLD--VAIPGGQFRWLTVDLPPIVDLRTRLLPSSPRVSVCAQSA
Rv1153c|M.tuberculosis_H37Rv LQTSFWRLD--VAIPGGQFRWLTVDLPPIVDLRTRLLPSSPRVSVCAQSA
Mflv_2136|M.gilvum_PYR-GCK LQTSFYRLDSGPESVGHDFRWLTVDLPPMIDLRTKLLPPSDRVRTLAQSA
MSMEG_5173|M.smegmatis_MC2_155 LQTSFYRLN--EAGVGDQFCWLTVDLPPMVEIRNKLLPPSDRVRTCAQSA
TH_0460|M.thermoresistible__bu LQTSFFRLN--AADVGDEFRWVTVDLAPVIELRRQLLPADDRVTMLAQSA
Mvan_0979|M.vanbaalenii_PYR-1 LQTSFWRLD--AAIPDSRFRWVSIDLEPVIALRRRLLPDSPRITTLAQSA
MAV_2991|M.avium_104 LDGRAFRVS-----VPPSLSWFDVDQPSVIGLRRRLYDDTENYRMIGSSV
*: :*:. : *. :* .:: :* :* . ..*.
MMAR_0262|M.marinum_M FDYSWMEQVDDTNGVLITAEGLFQYLRRDVVFELIAACAKRFPHGQLVFD
MUL_4852|M.ulcerans_Agy99 FDYSWMEQVDDTNGVLITAEGLFQYLRRDVVFELIAACAKRVPHGQLVFD
MAB_1292c|M.abscessus_ATCC_199 LDHSWMDQVDDSNGVLITAEGLFMYLERDVVFDLIAACAKRFPGGWMVFD
Mb1184c|M.bovis_AF2122/97 LDYSWMDSVDPAGGVFITAEGLLMYLQPEQALGLIAQCAQTFPGGQMLFD
Rv1153c|M.tuberculosis_H37Rv LDYSWMDSVDPAGGVFITAEGLLMYLQPEQALGLIAQCAQTFPGGQMLFD
Mflv_2136|M.gilvum_PYR-GCK LDFSWMDQVDTSEGVFITAEGLLMYLQPAEAMSLITECAARFPGGQMIFD
MSMEG_5173|M.smegmatis_MC2_155 LDYSWMDQVDDSEGVFITAEGLLMYLQPEESMGLIKECARRFPGGQMIFD
TH_0460|M.thermoresistible__bu LDYSWMDRIDTSEGVFITAEGLLMYLQPDEAMGLIRECARRFPGGQMMFD
Mvan_0979|M.vanbaalenii_PYR-1 LDYSWMDAVDTTDGVFITAEGLLMYLQPDEAMDLITACASRFPGGQMIFD
MAV_2991|M.avium_104 TELQWLDEVPAGRPTLMVAEGLLMYLREDEVRRLLQRLIDRFPGGEMHFD
: .*:: : .::.****: **. *: .* * : **
MMAR_0262|M.marinum_M SIPWLLSVYSRRRGFRLSEHYTAPPMPFWFTADHYDELR-AIPGVRAVRE
MUL_4852|M.ulcerans_Agy99 SIPWLLSVYSRRRGFKLSEHYTAPPMPFWFTADHYDELR-AIPGVRAVRE
MAB_1292c|M.abscessus_ATCC_199 TIPWLMSVYSRRRGWRLSEHYTVPPMPFSFTAHQYGQLR-ALDGVSAVRE
Mb1184c|M.bovis_AF2122/97 LPPRWFAGWSR-LGLRTSLRYKVPRMPFSMSVAQAADLVNKVPGVVAVRD
Rv1153c|M.tuberculosis_H37Rv LPPRWFAGWSR-LGLRTSLRYKVPRMPFSMSVAQAADLVNKVPGVVAVRD
Mflv_2136|M.gilvum_PYR-GCK LPPSAFAFLVG-RGVRASLRYRVPPMPFSLTIAEAADLVNTVPGVRAVHD
MSMEG_5173|M.smegmatis_MC2_155 LPPSWFAAWAR-KGMRTSRRYRVPPMPFSLSPAEVADLVNTVPGVRVVHD
TH_0460|M.thermoresistible__bu LPPSFFAWLTR-RGFRTSLRYKVPPMPFTLSPEQAADLVNTVPGVQAVHD
Mvan_0979|M.vanbaalenii_PYR-1 LPPTMVKKIAP-KGMRSSARYRVPPMPFSLSPAQLAELVHTVPGVTAVHD
MAV_2991|M.avium_104 TLSALAPLLSK----------VFTRGIITWGIRDARRIADWNPRLRFLEQ
. . : . : : :.:
MMAR_0262|M.marinum_M LPAPAGRGRFLRWALPVAYRLPGLGRLRAPVTLVEFG-------
MUL_4852|M.ulcerans_Agy99 LPAPAGRGRFLRWALPVAYRLPGLGRLRAPVTLVEFG-------
MAB_1292c|M.abscessus_ATCC_199 VRMPAGRGTFLKLATPLFYNLPLSDRIRPAMTVVEFG-------
Mb1184c|M.bovis_AF2122/97 LRVPPGRGLWVNMALSTVYRLPVFDPLRPCLTLLEFSRPARG--
Rv1153c|M.tuberculosis_H37Rv LRVPPGRGLWVNMALSTVYRLPVFDPLRPCLTLLEFSRPARG--
Mflv_2136|M.gilvum_PYR-GCK LPAEHARGRLINALLWTAQRVPLLDPIRPMFTLLEFG-------
MSMEG_5173|M.smegmatis_MC2_155 LPFPPARGKFMRTVVWGVQRLPLFDPIRPVMALLEFG-------
TH_0460|M.thermoresistible__bu VPIPRGRGVLVNTLIWAAQRTPLFDNVRGTYTLLEFGPPNSAST
Mvan_0979|M.vanbaalenii_PYR-1 LPMPRGRGFLFERVFPAFWQFKPTRNYRGAYTLLEFG-------
MAV_2991|M.avium_104 SPALAGYQRIPSTVVRSIYRLTWLTGGRGYDVLNRFEY------
. . * .: .*