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DYAALPPEINSARMYSGPGSTSMQTAATAWDALATELYSAASCYSSITAGLAGKWQGPAATAMAQAAAPY AAWLSTTAAQAELASAQARAAVSAHAGAFAATVPPPVIAANRAHLAALIATNLLGQNSPAIATTEANYEQ MWAQDAAAMYGYAGACASATRLTPFTSPPPITDPVGLARQGVAATQSTGASAAAPSLEAVLAASQVITTL PGTLAGLATAPIMTSLNSAFTSLSTSLSKLSSLAVPLNFAMYALNFLDKGIGFTKAATGSLTAAATGAVK AVESGAQSLGSVSLGITGSGAALSAAMGRGMTVGALSVPHSWITAPATSAVAANLPSSLSSVGTLDSGTA GMPFMPLTGMAGRSANGPAASRFELRSTVVPRSPAAG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_1847 | - | - | 100% (388) | PPE family protein |
| M. marinum M | MMAR_1849 | - | 5e-81 | 44.65% (430) | PPE family protein |
| M. marinum M | MMAR_1461 | - | 3e-75 | 42.79% (423) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1836 | PPE31 | 6e-80 | 44.85% (408) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0325 | - | 1e-29 | 36.89% (206) | PPE protein |
| M. tuberculosis H37Rv | Rv1807 | PPE31 | 2e-79 | 44.61% (408) | PPE family protein |
| M. leprae Br4923 | MLBr_01182 | - | 2e-55 | 35.08% (419) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_4783 | - | 2e-31 | 28.89% (360) | PPE family protein |
| M. avium 104 | MAV_3356 | - | 2e-76 | 45.21% (407) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 3e-29 | 34.43% (212) | PPE family protein |
| M. thermoresistible (build 8) | TH_3113 | - | 4e-36 | 30.91% (440) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_2096 | - | 0.0 | 98.97% (388) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 1e-35 | 32.27% (375) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1836|M.bovis_AF2122/97 -------------MDFATLPPEINSARMYSGAGSAPMLAAASAWHGLSAE
Rv1807|M.tuberculosis_H37Rv -------------LDFATLPPEINSARMYSGAGSAPMLAAASAWHGLSAE
MMAR_1847|M.marinum_M -------------MDYAALPPEINSARMYSGPGSTSMQTAATAWDALATE
MUL_2096|M.ulcerans_Agy99 -------------MDYAALPPEINSARMYAGPGSTSMQTAATAWDALATE
MAV_3356|M.avium_104 -------------MDFGSLPPEINSGRIYSGPGSAPLLAAAAAWHGLAAE
MLBr_01182|M.leprae_Br4923 ------------MFDFAALSPETNSTRMYLGPGSSPILTAAAAWVVLAKE
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE
MSMEG_0619|M.smegmatis_MC2_155 ----------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAE
MAB_4783|M.abscessus_ATCC_1997 ----------MTAPVWMAAPPEVHSALLSSGPGPGSLFAAADAWRSLSTE
TH_3113|M.thermoresistible__bu ----------------MALPPEVHSTLLRTGPGPGALSAAADAWRMLSDE
: .** :* : *.*. .: :*. :* *: *
Mb1836|M.bovis_AF2122/97 LRASALSYSSVLSTLTGEEWHGPASASMTAAAAPYVAWMSVTAVRAEQAG
Rv1807|M.tuberculosis_H37Rv LRASALSYSSVLSTLTGEEWHGPASASMTAAAAPYVAWMSVTAVRAEQAG
MMAR_1847|M.marinum_M LYSAASCYSSITAGLA-GKWQGPAATAMAQAAAPYAAWLSTTAAQAELAS
MUL_2096|M.ulcerans_Agy99 LYSAASCYSSITAGLA-GKWQGPAATAMAQAAAPYAAWLSTTAAQAELAS
MAV_3356|M.avium_104 MHSAAASYGSAIAELR-TLWHGPSSTAMAAAAAPFIAWLDGTAVQAEQTA
MLBr_01182|M.leprae_Br4923 LTAAAQGLQSAVEALL-TTFEGESAAALAERVTPYEKWLTQNAASAELTA
Mflv_0325|M.gilvum_PYR-GCK YASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA
Mvan_0415|M.vanbaalenii_PYR-1 YAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA
MSMEG_0619|M.smegmatis_MC2_155 YAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAA
MAB_4783|M.abscessus_ATCC_1997 YSSAANELTTTLGSVRAGVWDGASAEQYQTAHVPYLSWLHETSAVSAGVA
TH_3113|M.thermoresistible__bu YRAAAVELAAVVSQTCATAWEGVGADAYAAAHGPYLFWLTDTAAAAAAAG
::* : :.* .: *: *: :. . ..
Mb1836|M.bovis_AF2122/97 AQAEAAAAAYEAAFAATVPPPVIEANRAQLMALIATNVLGQNAPAIAATE
Rv1807|M.tuberculosis_H37Rv AQAEAAAAAYEAAFAATVPPPVIEANRAQLMALIATNVLGQNAPAIAATE
MMAR_1847|M.marinum_M AQARAAVSAHAGAFAATVPPPVIAANRAHLAALIATNLLGQNSPAIATTE
MUL_2096|M.ulcerans_Agy99 AQARAAVSAHAGAFAATVPPPVIAANRAHLAALIATNLLGQNSPAIATTE
MAV_3356|M.avium_104 AQATAAAAAYDSVFAATVPPPVIAANRALLASLIATNVLGQNTPAIAATE
MLBr_01182|M.leprae_Br4923 TQLTVAANAYETAFTMTVPPLMVFVNRAQACLLIMSNIFGQNSTAIAEKE
Mflv_0325|M.gilvum_PYR-GCK VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE
Mvan_0415|M.vanbaalenii_PYR-1 AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE
MSMEG_0619|M.smegmatis_MC2_155 VQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNE
MAB_4783|M.abscessus_ATCC_1997 AQTETAATAYSEALATMPTLGELAANHATHGALVATNFFGINTIPIAVNE
TH_3113|M.thermoresistible__bu AQLEAAAAAHASALAAMPTMAELTANRTTHAALVATNFFGVNTIPIAVNE
.* .*. *: .:: . : *:: *: :*.:* *: .** .*
Mb1836|M.bovis_AF2122/97 AQYAEMWSQDAMAMYGYAGASAAAT-QLTPFTEPVQTTNASGLAAQSAAI
Rv1807|M.tuberculosis_H37Rv AQYAEMWSQDAMAMYGYAGASAAAT-QLTPFTEPVQTTNASGLAAQSAAI
MMAR_1847|M.marinum_M ANYEQMWAQDAAAMYGYAGACASAT-RLTPFTSPPPITDPVGLARQGVAA
MUL_2096|M.ulcerans_Agy99 ANYEQMWAQDAAAMYGYAGACASAT-RLTPFTSPPPITDPVGLARQGVAA
MAV_3356|M.avium_104 AHYAEMWAQDAAAMYAYAGASAVAT-RLTPFGAPPQTADANAAADQSAAA
MLBr_01182|M.leprae_Br4923 AEYTEMWIQDAAAMTSYQASVLEAVGATKAFTAPPLGVNEVGLAQEVVEE
Mflv_0325|M.gilvum_PYR-GCK ADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLPGVGEAGRAAA
Mvan_0415|M.vanbaalenii_PYR-1 ADYVRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPGVGEAGRAAA
MSMEG_0619|M.smegmatis_MC2_155 ADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPGVGEAGSASA
MAB_4783|M.abscessus_ATCC_1997 ADYIRMWIQAATVMSTYQAVSESSVSAAPPTSPAPPVLSPDSGAAART--
TH_3113|M.thermoresistible__bu ADYARMWIQAATTMATYEAVASAAVSATPRTVAPPPILGAGTGESATAAI
*.* .** * * .* * . : . .
Mb1836|M.bovis_AF2122/97 A---HATGASAG----------------------------AQQTTLSQLI
Rv1807|M.tuberculosis_H37Rv A---HATGASAG----------------------------AQQTTLSQLI
MMAR_1847|M.marinum_M T---QSTGAS------------------------------AAAPSLEAVL
MUL_2096|M.ulcerans_Agy99 T---QSTGAS------------------------------AAAPSLEAVL
MAV_3356|M.avium_104 ASALQSSTASSVES--------------------------ALSQAVSQVP
MLBr_01182|M.leprae_Br4923 VVEEVVEEVVEAEQ--------------------------AISQAALDQA
Mflv_0325|M.gilvum_PYR-GCK DMSAFAAQPMAAQAGAAFDVSNIIADIIRLYGEVLRFLFEPIFNFLRDPI
Mvan_0415|M.vanbaalenii_PYR-1 DVTAFAAQAQAAEAGSALDLSNIIADLIRAYGELLRFLFEPIFDFLRDPL
MSMEG_0619|M.smegmatis_MC2_155 SVQQMSAQATAAESGSSLDLSSIISDLLNQYLQGVPGG-QAILDFLKDPL
MAB_4783|M.abscessus_ATCC_1997 -----AAQDATKPPPIVPDPNDPIEMLLKNS-QHFLGMYRALKGLITDPV
TH_3113|M.thermoresistible__bu TGAHVTAELRAAESRTLLDEINELIDRLFAP----LFPPGFADALPDGLL
Mb1836|M.bovis_AF2122/97 AAIPSVLQGLSSSTAATSASGPSGLLGILGSG------------------
Rv1807|M.tuberculosis_H37Rv AAIPSVLQGLSSSTAATFASGPSGLLGIVGSG------------------
MMAR_1847|M.marinum_M AASQVITT--LPGTLAGLATAP-----IMTSL------------------
MUL_2096|M.ulcerans_Agy99 AASQVITT--LPGTLAGLVTAP-----IMTSL------------------
MAV_3356|M.avium_104 VAAQVNAT--AVTAAAQLPLSLTDITGILKTF------------------
MLBr_01182|M.leprae_Br4923 VNEGMEATVVPQVDQQVNVDVATPQTAVPDSS------------------
Mflv_0325|M.gilvum_PYR-GCK GNTFALITDFLTNPVQALITWGPFLLAVVYQA----VSWVGASILYPSLF
Mvan_0415|M.vanbaalenii_PYR-1 GNTIKLITDFLTNPAQALITWGPFLAAVAYQA----VSWVGASILYPSLL
MSMEG_0619|M.smegmatis_MC2_155 GNLGRLLTDFMTNPAGALATWWPFLFGVAYQVFFNLVGWPTWGMIFASPF
MAB_4783|M.abscessus_ATCC_1997 GTIVRIIIDFSTNPAAAIVTWTPLFYVFAYAA-----TFAVMGTPIYAAI
TH_3113|M.thermoresistible__bu GTLLAPLLPGATGDGPPMATIMSFLLMGLSNP---AYLFPVLVYLLFTGV
Mb1836|M.bovis_AF2122/97 ------------------------SSWLDKLWALLDPNSN-----FWNTI
Rv1807|M.tuberculosis_H37Rv ------------------------SSWLDKLWALLDPNSN-----FWNTI
MMAR_1847|M.marinum_M ------------------------NSAFTSLSTSLSKLSS-----LAVPL
MUL_2096|M.ulcerans_Agy99 ------------------------NSAFTSLSTSLSKLSS-----LAVPL
MAV_3356|M.avium_104 ------------------------NSVMGTISGPYTPLGV-----ANLAK
MLBr_01182|M.leprae_Br4923 ------------------------SAAAPQLWGGFAQHLSPINDTLSMIN
Mflv_0325|M.gilvum_PYR-GCK LLPLLATT--LAIVAGVGQHLLSLLNTPPAEEAAEEPAPAQSAPSRPDQQ
Mvan_0415|M.vanbaalenii_PYR-1 LLPLVATT--LAIVLGVGAYLLENLPAPAEDAPAEEPAASSPAPTRADQP
MSMEG_0619|M.smegmatis_MC2_155 LIPALAALGITGLVLLIDHVLNNPVDVPAEDEAPQEVAAAP----RTDQP
MAB_4783|M.abscessus_ATCC_1997 MGPAAGISIPLAITLAS---LSQMPEAPPVDAPAETVPARIDQPHAVAMG
TH_3113|M.thermoresistible__bu VHTTVAVSGMLAQLVPLMPALLPVAVAALGGLAGVWAGLSGLAGLAGLTA
Mb1836|M.bovis_AF2122/97 ASSGLFLPSNTIAPFLGLLGGVAAADAAGDVLGEATSGGLGGALVAPLGS
Rv1807|M.tuberculosis_H37Rv ASSGLFLPSNTIAPFLGLLGGVAAADAAGDVLGEATSGGLGGALVAPLGS
MMAR_1847|M.marinum_M NFAMYALNFLDKGIGFTKAATGSLTAAATGAVKAVESGAQSLGSVS-LGI
MUL_2096|M.ulcerans_Agy99 NFAMYALNFLDKGIGFTKAATGSLTAAATGAVKAVESGAQSLGSVS-LGI
MAV_3356|M.avium_104 NWYQIALSIPSVGTGIQGIGPLLHPKALTGVLAPLLRSDLLTGSTA-LSS
MLBr_01182|M.leprae_Br4923 NHAGMANAGLSLVNGMGSAMKSLAPTTTKAAESAFKAMGSAVQSTGRGLL
Mflv_0325|M.gilvum_PYR-GCK SFPATMSAPPPPSGAPIAANTVSAGSPPAPGAPAAAAATFVPYVVAGRDP
Mvan_0415|M.vanbaalenii_PYR-1 SPAIAVSAPPPPSSAAATVGTVATGTAPAPGAPAAATASFVPYAVAGRDP
MSMEG_0619|M.smegmatis_MC2_155 -LAVGISPAGVPGSAATAAAPAPAPAGTTVAAPAPAAATFVPYAVANRDP
MAB_4783|M.abscessus_ATCC_1997 GAPAPTASTAAP--TPTTTSPATPGSAPAP-TPPPAGAEGLGYAVRGDGP
TH_3113|M.thermoresistible__bu VPAADGGASAAPVPAGGPSLPSGSSAPPAPTGSAAPTTGTAPGGAGSPPP
.
Mb1836|M.bovis_AF2122/97 AGGLGGTVAAGLGNAATVGTLSVPPSWTAAAPLASPLGSALGGTPMVAPP
Rv1807|M.tuberculosis_H37Rv AGGLGGTVAAGLGNAATVGTLSVPPSWTAAAPLASPLGSALGGTPMVAPP
MMAR_1847|M.marinum_M TGSGA-ALSAAMGRGMTVGALSVPHSWITA-PATSAVAANLPSSLSSVG-
MUL_2096|M.ulcerans_Agy99 TGSGA-ALSAPMGRGMTVGALSVPHSWITA-PATSAVAANLPSSFSSVG-
MAV_3356|M.avium_104 AGT----VSASAGRAGLVGALSVPANWASAVPAVRTVAAELPETMLDAAP
MLBr_01182|M.leprae_Br4923 GSSSGGHVTAQLGRAASIGSLRVPQTWTTASQPVTAATRALSPARVAVAT
Mflv_0325|M.gilvum_PYR-GCK YEGFSPTVRDSTGAKAPAGTIPAAASGIAASAAERRKRRRRQKEEIKGRG
Mvan_0415|M.vanbaalenii_PYR-1 GTGFSPTVRDSTSAKAPASGIPAAASGVAASAAERRKRRRRQKDEIAGRA
MSMEG_0619|M.smegmatis_MC2_155 GEGFTPTLGNKSQVAAPASGVPAAASGVAASLASRRKRRRKKGAQIEERG
MAB_4783|M.abscessus_ATCC_1997 GFGFGPTIGASTGATAHAPSSAVSAAAALACNPATGKSRRRRRRTIDDRG
TH_3113|M.thermoresistible__bu AGHSVPPAPHSAPPVGTSGPPYLIAAQPAPGVARRSAGARRAASIVEPAG
.
Mb1836|M.bovis_AF2122/97 PAVAAGMP--GMP----FGTMGGQGFG-RAVPQYGFRPNFVAR--PPAAG
Rv1807|M.tuberculosis_H37Rv PAVAAGMP--GMP----FGTMGGQGFG-RAVPQYGFRPNFVAR--PPAAG
MMAR_1847|M.marinum_M -TLDSGTA--GMP-FMPLTGMAGRSANGPAASRFELRSTVVPR--SPAAG
MUL_2096|M.ulcerans_Agy99 -TLDSGTA--GMP-FMPLTGMAGRSANGPAASRFELRSTVVPR--SPAAG
MAV_3356|M.avium_104 AMAVNGQQ--GMFGPTALSSLAGRAVGGTATRAVAGSTVRVPG--AVAVD
MLBr_01182|M.leprae_Br4923 ESESAPLLGGGLPMAPMVPGGGSGTGGVNTALRLQPRAFVMPR--NPAAG
Mflv_0325|M.gilvum_PYR-GCK YADAYADYEELPDDGPPEQPAPRVTASTRGAGPMGFAGTVSRG-DEQAGG
Mvan_0415|M.vanbaalenii_PYR-1 YADAYADYEPEPDDEPPVRQEPRIAATERGAGPMGFAGTVSRD-AAQAGG
MSMEG_0619|M.smegmatis_MC2_155 YADAYMDYEE-PDEDPAPQPEPRVRASERGSDAMGFTGTVTRH-DVTAAG
MAB_4783|M.abscessus_ATCC_1997 YRHEYATMDDHTPTGP--QDPVTAVASGTGAGRLGFAGVHTATTAVEATG
TH_3113|M.thermoresistible__bu SAAAAAAARESAPIRRRRGQKDGLHGHRHEHQQPASMSAATAP---SAAG
* .
Mb1836|M.bovis_AF2122/97 -----------------------------------------------
Rv1807|M.tuberculosis_H37Rv -----------------------------------------------
MMAR_1847|M.marinum_M -----------------------------------------------
MUL_2096|M.ulcerans_Agy99 -----------------------------------------------
MAV_3356|M.avium_104 DLATTSTVIVIPPNAK-------------------------------
MLBr_01182|M.leprae_Br4923 -----------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK LTTLAGDSFGGGPREPMLPGTWDPDATDDRHTDGRDGHDGHDGKEKP
Mvan_0415|M.vanbaalenii_PYR-1 LTTLPGDPFGGGPKAPMLPGTWDPDTEPD------ERHNHHDGKDSQ
MSMEG_0619|M.smegmatis_MC2_155 LTTLTGDTFDDRPVTPMLPGTWDGDENPAP------SPDDPEGGPRR
MAB_4783|M.abscessus_ATCC_1997 LSTLDGDAEN--RTIPMLPGTWDVTDDDR------------------
TH_3113|M.thermoresistible__bu IRVLGGAGRISRTRGSVPHAEITPGDPTEPSSPTDRAHRPAEPN---