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TIHTHLQSISTTLGEIAVHDVPAAGGADAPTLVMLHGGGPGASGLSNYEQNIPALSRTFRILLPDQPGFG GSYRPTGADLDERSITEITVDALFQVLDDLAVGSFHLLGNSLGGAAAIRMAQLRPERVTRLVLMAPGGGW LPFGPTPTEGQKEMFRYFNGEGPTEKKMAAFIRAMVFDHKQFGRDVVSRRYQASLDEGHIEFYHHYNAAF AKRNGMDPLWRDLHTITAPTLLLWGRDDRTITLEGAQMMLKHISDVQLHVFGRCGHWVQLERQAEFDRLV ADFLGEPA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_4366c | - | - | 100% (289) | putative hydrolase, alpha/beta fold |
| M. abscessus ATCC 19977 | MAB_3810 | - | 1e-35 | 30.66% (287) | putative hydrolase, alpha/beta fold |
| M. abscessus ATCC 19977 | MAB_0679c | - | 1e-11 | 25.25% (297) | hydrolase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3600c | bphD | 2e-49 | 39.49% (276) | 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD |
| M. gilvum PYR-GCK | Mflv_1464 | - | 6e-50 | 40.68% (263) | alpha/beta hydrolase fold |
| M. tuberculosis H37Rv | Rv3569c | bphD | 2e-49 | 39.49% (276) | 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD |
| M. leprae Br4923 | - | - | - | - | - |
| M. marinum M | MMAR_5064 | bphD | 8e-52 | 40.15% (274) | 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD |
| M. avium 104 | MAV_0592 | - | 6e-50 | 40.47% (257) | 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase |
| M. smegmatis MC2 155 | MSMEG_6037 | - | 7e-51 | 41.67% (276) | 2-hydroxy-6-ketonona-2,4-dienedioic acid hydrolase |
| M. thermoresistible (build 8) | TH_1741 | - | 5e-50 | 40.82% (267) | 2-HYDROXY-6-OXO-6-PHENYLHEXA-2,4-DIENOATE HYDROLASE BPHD |
| M. ulcerans Agy99 | MUL_4140 | bphD | 7e-52 | 40.15% (274) | 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD |
| M. vanbaalenii PYR-1 | Mvan_5307 | - | 4e-51 | 40.91% (264) | alpha/beta hydrolase fold |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3600c|M.bovis_AF2122/97 -------MTATEELTFESTSRFAEVDVD-GPLKLHYHEAGV---GNDQTV
Rv3569c|M.tuberculosis_H37Rv -------MTATEELTFESTSRFAEVDVD-GPLKLHYHEAGV---GNDQTV
MAV_0592|M.avium_104 -------MTATEELTFESTSRFAEVDVD-GPLKLHYHEAGLSFKGTGRTV
MMAR_5064|M.marinum_M ---MTVTQSKTAEHTFESTSRYAEVDVD-GPLKLHYHEAGV---GNDQTV
MUL_4140|M.ulcerans_Agy99 ---MTVTQSKTAEHTFESTSRYAEVDVD-GPLKLHYHEAGV---GNDQTV
Mflv_1464|M.gilvum_PYR-GCK MTSFAAEAAQQQEITFESTSRYAQVR---EDMRLHYHEAGV---GNPKTV
Mvan_5307|M.vanbaalenii_PYR-1 MTSFAAEAAQQQEITFESTSRFAQVR---EDMRLHYHEAGD---PESPTV
TH_1741|M.thermoresistible__bu MTSYIQEAENQVEITFESTSRYAEVKAGDRDMRLHYHEAGI---GHAQKV
MSMEG_6037|M.smegmatis_MC2_155 ------MVTATQEITFESTSRFADVQAGELAMRLHYHEAGD---PSAQTI
MAB_4366c|M.abscessus_ATCC_199 -------MTIHTHLQSISTT-LGEIAVH------DVPAAGG---ADAPTL
. **: .:: . ** .:
Mb3600c|M.bovis_AF2122/97 VLLHGGGPGAASWTNFSRNIAVLARHFHVLAVDQPGYGHSDKRA----EH
Rv3569c|M.tuberculosis_H37Rv VLLHGGGPGAASWTNFSRNIAVLARHFHVLAVDQPGYGHSDKRA----EH
MAV_0592|M.avium_104 VLLHGGGPGAASWTNFGRNIPVLARHFHVLAVDQPGYGLSDKRA----EH
MMAR_5064|M.marinum_M VLLHGGGPGASSWSNFARNIEVLAQQFHVLAVDQPGYGHSDKRA----EH
MUL_4140|M.ulcerans_Agy99 VLLHGGGPGASSWSNFARNIEVLAQQFHVLAVDQPGYGHSDKRA----EH
Mflv_1464|M.gilvum_PYR-GCK VLLHGGGPGASSWSNFGRNIPVLAKHFHVLAVDQPGYGHSDKHT----EH
Mvan_5307|M.vanbaalenii_PYR-1 VLLHGGGPGASSWSNFGKNIPVLAEHFHVLAVDQPGYGHSDKHT----EH
TH_1741|M.thermoresistible__bu VLLHGGGPGASSWSNFGRNIAVLARHFHVIAVDQPGYGHSDKHT----EH
MSMEG_6037|M.smegmatis_MC2_155 VLLHGGGPGAASWSNFGRNIAVLAEHFHVLAVDQPGYGLSDKHT----EH
MAB_4366c|M.abscessus_ATCC_199 VMLHGGGPGASGLSNYEQNIPALSRTFRILLPDQPGFGGSYRPTGADLDE
*:********:. :*: :** .*:. *::: ****:* * : : :.
Mb3600c|M.bovis_AF2122/97 GQFNRYAAMALKGLFDQLGLG-RVPLVGNSLGGGTAVRFALDYPARAGRL
Rv3569c|M.tuberculosis_H37Rv GQFNRYAAMALKGLFDQLGLG-RVPLVGNSLGGGTAVRFALDYPARAGRL
MAV_0592|M.avium_104 GQFNRYAARALNGLFEQLELG-RVPLVGNSLGGGTAVRFALDYPDKAGRL
MMAR_5064|M.marinum_M GQFNHYAARALKELFDQLGLG-RVPLVGNSLGGGTAVRFALDYPDRAGRL
MUL_4140|M.ulcerans_Agy99 GQFNHYAARALKELFDQLGLG-RVLLVGNSLGGGTAVRFALDYPDRAGRL
Mflv_1464|M.gilvum_PYR-GCK EQYNRYSATALLNLFDHLGIE-KAALVGNSLGGGTAVRFALDNGKRAGKL
Mvan_5307|M.vanbaalenii_PYR-1 EQYNRYSATALLNLFDYLGIE-RAALVGNSLGGGTAVRFALDNGKRAGKL
TH_1741|M.thermoresistible__bu EQYNRYSATALLALFDHLGIE-RADLVGNSLGGGTAVRFALDHPKRAGRL
MSMEG_6037|M.smegmatis_MC2_155 EQYNRYSAKAVRGLLDHLGVEGRVPLLGNSLGGGTAVRFALDYPDRAGKL
MAB_4366c|M.abscessus_ATCC_199 RSITEITVDALFQVLDDLAVG-SFHLLGNSLGGAAAIRMAQLRPERVTRL
. .. :. *: ::: * : *:******.:*:*:* :. :*
Mb3600c|M.bovis_AF2122/97 VLMGPGGLSINLFAPDPTEGVKRLSKFS--VAPTRENLEAFLRVMVYDKN
Rv3569c|M.tuberculosis_H37Rv VLMGPGGLSINLFAPDPTEGVKRLSKFS--VAPTRENLEAFLRVMVYDKN
MAV_0592|M.avium_104 VLMGPGGLSINLFAPDPTEGVKRLGKFS--AEPTRENLEAFLRVMVYDQK
MMAR_5064|M.marinum_M VLMGPGGLSINLFAPDPTEGVKRLGKFS--VAPTRENLEAFLRVMVYDQK
MUL_4140|M.ulcerans_Agy99 VLMGPGGLSINLFAPDPTEGVKRLGKFS--VAPTRENLEAFLRVMVYDQK
Mflv_1464|M.gilvum_PYR-GCK VLMGPGGLSVNLFSPDPTEGVKLLGRFA--AEPTRENIEKFLRIMVFDQA
Mvan_5307|M.vanbaalenii_PYR-1 VLMGPGGLSVNLFSPDPTEGVKLLGKFA--AEPTRENIEKFLRIMVFDQN
TH_1741|M.thermoresistible__bu VLMGPGGLSVNMFAPDPTEGVKLLARFN--AEPTRENLEAFLRIMVYDQS
MSMEG_6037|M.smegmatis_MC2_155 VLMGPGGLSVNLFAPDPTEGVKALAKFN--VEPTRENLEAFLRIMVFDQK
MAB_4366c|M.abscessus_ATCC_199 VLMAPGGGWL-PFGPTPTEGQKEMFRYFNGEGPTEKKMAAFIRAMVFDHK
***.*** : *.* **** * : :: **.::: *:* **:*:
Mb3600c|M.bovis_AF2122/97 LITPELVDQRFALASTPESLTATRAMGKSFAGADFEAGMMWREVYRLRQP
Rv3569c|M.tuberculosis_H37Rv LITPELVDQRFALASTPESLTATRAMGKSFAGADFEAGMMWREVYRLRQP
MAV_0592|M.avium_104 LITDELIDERFALASTPESLAATRAMGMSFAGADFELGMMWREVHRLRQP
MMAR_5064|M.marinum_M LITPELVDQRFELARTPESLAATRAMGKSFAAADFELGMMWREVYKLRQP
MUL_4140|M.ulcerans_Agy99 LITPELVDQRFELARTPESLAATRAMGKSFAAADFELGMMWREVYKLRQP
Mflv_1464|M.gilvum_PYR-GCK MITPELVEERFQIASTPESLAATKAMGKSFAGADFELGMMWRDVYKLRQR
Mvan_5307|M.vanbaalenii_PYR-1 MITPELVEERFQIASTPESLAATKAMGKSFAGADFELGMMWRDVYKLRQR
TH_1741|M.thermoresistible__bu LITEELIDERFAIAATPESLAATRAMGKSFMGPDFELGMMWRDAYKLRQR
MSMEG_6037|M.smegmatis_MC2_155 LITPELVEERFAIASTPESLAATRAMGKSFAGADFELGMMWREVYKLRQP
MAB_4366c|M.abscessus_ATCC_199 QFGRDVVSRRYQASLDEGHIEFYHHYNAAFAKRN-GMDPLWRDLHTITAP
: :::..*: : : : . :* : . :**: : :
Mb3600c|M.bovis_AF2122/97 VLLIWGREDRVNPLDGALVALKTIPRAQLHVFGQCGHWVQVEKFDEFNKL
Rv3569c|M.tuberculosis_H37Rv VLLIWGREDRVNPLDGALVALKTIPRAQLHVFGQCGHWVQVEKFDEFNKL
MAV_0592|M.avium_104 VLLIWGREDRVNPLDGALVALKTIARAQLHVFGQCGHWAQVEKFDEFNKL
MMAR_5064|M.marinum_M VLLIWGREDRVNPLDGALVALKTIPRAQLHVFGQCGHWAQVEKFDEFNRL
MUL_4140|M.ulcerans_Agy99 VLLIWGREDRVNPLDGALVALKTIPRAQLHVFGQCGHWAQVEKFDEFNRL
Mflv_1464|M.gilvum_PYR-GCK VLLIWGREDRVNPLDGALVALKQIPRVQLHVFGQCGHWAQLEKFDEFNKL
Mvan_5307|M.vanbaalenii_PYR-1 VLLIWGREDRVNPLDGALVALKQIPRVQLHVFGQCGHWAQLEKFDEFNKL
TH_1741|M.thermoresistible__bu VLLIWGREDRVNPLDGALVALKQIPRVQLHVFGQCGHWAQVEKFDEFNRL
MSMEG_6037|M.smegmatis_MC2_155 VLLIWGREDRVNPLDGALVAVKQIPRVQLHVFGQCGHWAQVEKFDEFNKL
MAB_4366c|M.abscessus_ATCC_199 TLLLWGRDDRTITLEGAQMMLKHISDVQLHVFGRCGHWVQLERQAEFDRL
.**:***:**. .*:** : :* *. .******:****.*:*: **::*
Mb3600c|M.bovis_AF2122/97 TIEFLGGGR-----
Rv3569c|M.tuberculosis_H37Rv TIEFLGGGR-----
MAV_0592|M.avium_104 TIDFLGGA------
MMAR_5064|M.marinum_M TIDFLGGAR-----
MUL_4140|M.ulcerans_Agy99 TIDFLGGAR-----
Mflv_1464|M.gilvum_PYR-GCK TIDFLTN-------
Mvan_5307|M.vanbaalenii_PYR-1 TIDFLGGG------
TH_1741|M.thermoresistible__bu TIDFLEDGAKEAKS
MSMEG_6037|M.smegmatis_MC2_155 TIDFLGG-------
MAB_4366c|M.abscessus_ATCC_199 VADFLGEPA-----
. :**