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AETLVELLEGLRDRGDHTLLVCDDERLTYADAEHRSARLADALIALGAGKGTHVGVLYPNGADFVVAMLA VARVGAVVVPFSTFLTEAELRVQLLDSDVSIMLSARSFRSHDYVGQISRVRADAPCLRHVVFEIPAAGDP ERRAGLEADVEGSDVLAIIYTSGSTGAPKGVVHTHSSLLAHQRDLNVLRGLTADDKLFCNSPFFWVGGLA FALLASMIAGATLVCSNSTDAGATFDLLEAEKPTITNGFVAGIAHLTRHPSFPHRNLSSIRRGNLYPLMA PDVRPADPDLRHNMLGSTESGSVVLLDPDDTDQPEHRRGSFGRPAPGFETKVLDSGELCIRGPYLMQGYY GRSREECFDTDGWFHTGDLVRVDDDGYFYFLGRAGAMIKTAGANVTPDEVQKALQHVLEGRDMRDVTVQV VGLPDQERGQLVAAVVATADPAAFDEAAVRAALRAQLSSYKVPRRFAVIHSDELPVKSSGKIDVAALREL FDD*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_2216 | - | - | 100% (494) | AMP-binding enzyme |
| M. smegmatis MC2 155 | MSMEG_2215 | - | 8e-80 | 36.71% (493) | AMP-binding enzyme |
| M. smegmatis MC2 155 | MSMEG_3468 | - | 2e-64 | 36.45% (524) | AMP-binding enzyme |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3591 | fadD3 | 6e-51 | 31.87% (502) | acyl-CoA synthetase |
| M. gilvum PYR-GCK | Mflv_4363 | - | 0.0 | 65.04% (512) | AMP-dependent synthetase and ligase |
| M. tuberculosis H37Rv | Rv3561 | fadD3 | 4e-51 | 31.87% (502) | acyl-CoA synthetase |
| M. leprae Br4923 | MLBr_02546 | fadD2 | 1e-26 | 25.49% (506) | acyl-CoA synthetase |
| M. abscessus ATCC 19977 | MAB_4377c | - | 2e-58 | 32.41% (503) | AMP-binding domain protein |
| M. marinum M | MMAR_4026 | fadD35_1 | 1e-167 | 56.21% (523) | fatty-acid-CoA ligase FadD35_1 |
| M. avium 104 | MAV_1579 | - | 0.0 | 63.87% (512) | putative acyl-CoA dehydrogenase |
| M. thermoresistible (build 8) | TH_3971 | - | 1e-88 | 37.57% (527) | PUTATIVE putative putative acyl-CoA dehydrogenase |
| M. ulcerans Agy99 | MUL_4126 | fadD3 | 3e-46 | 30.99% (497) | acyl-CoA synthetase |
| M. vanbaalenii PYR-1 | Mvan_1981 | - | 1e-174 | 61.24% (516) | AMP-dependent synthetase and ligase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3591|M.bovis_AF2122/97 --------------------------MINDL--------------RTVPA
Rv3561|M.tuberculosis_H37Rv --------------------------MINDL--------------RTVPA
MUL_4126|M.ulcerans_Agy99 --------------------------MTSDP--------------RTVPT
MAB_4377c|M.abscessus_ATCC_199 ----------------MKAYDAGATLSPIIE--------------ETIGE
MMAR_4026|M.marinum_M --------------------------MAADS--------------PTVAQ
MAV_1579|M.avium_104 --------------------------MPGDF--------------ATVGA
Mflv_4363|M.gilvum_PYR-GCK ---------------------------MSDP--------------CTVAE
Mvan_1981|M.vanbaalenii_PYR-1 --------------------------MTPDP--------------ATVAD
MSMEG_2216|M.smegmatis_MC2_155 --------------------------MAETL--------------VELLE
TH_3971|M.thermoresistible__bu --------------------------MTSTPSATRVFRYEPLPYDAVLPA
MLBr_02546|M.leprae_Br4923 MTKLRHYLERGAAEVHYLRSIFESGALGFEPPLTYAAMAVAMRKWGDLAM
:
Mb3591|M.bovis_AF2122/97 ALDRLVRQLPDHTALIAE-----DRRFTSTELRDAVYGAAAALIALGVEP
Rv3561|M.tuberculosis_H37Rv ALDRLVRQLPDHTALIAE-----DRRFTSTELRDAVYGAAAALIALGVEP
MUL_4126|M.ulcerans_Agy99 ALDRLVRRLPNHDALVTD-----ERSFTVSELNDEVYRAAAALIELGVKP
MAB_4377c|M.abscessus_ATCC_199 NFERIARAHPDVGALVDVSG---DRRWTYRELDAEINRVARGLMSLGVAA
MMAR_4026|M.marinum_M ILRRQARCRPDHPFLVCDS-----DRISYAQADLRSAELARGLIALGIGK
MAV_1579|M.avium_104 TLRHQARWRGDHPLLICDA-----ERISYAEADVRSAELARGLIALGAGK
Mflv_4363|M.gilvum_PYR-GCK VLRAQRRHG-DKPLLICDD-----ERLSYAEADERSAVLAARLTTLGVGK
Mvan_1981|M.vanbaalenii_PYR-1 VLRRQRLWA-DKPLLVCDR-----TRLSYGEADERSAVLAQRLVALGAGK
MSMEG_2216|M.smegmatis_MC2_155 GLRD----RGDHTLLVCDD-----ERLTYADAEHRSARLADALIALGAGK
TH_3971|M.thermoresistible__bu MLAAVTGAHSAGDLVVTVTGDGSVERITYGEAEDRSADMAARLLAAGVTK
MLBr_02546|M.leprae_Br4923 LPAMPARRSPHRAALIDEE-----GTLTYKELDRAAHALANGLIAKGVRG
:: : : * * *
Mb3591|M.bovis_AF2122/97 ADRVAIWSPNTWHWVVACLAIHHAGAAVVPLNTRYTATEATDILDRAGAP
Rv3561|M.tuberculosis_H37Rv ADRVAIWSPNTWHWVVACLAIHHAGAAVVPLNTRYTATEATDILDRAGAP
MUL_4126|M.ulcerans_Agy99 AARVGIWSPNTWHWVVACLAIHHVGAAMVPLNTRYTADEAADILARTEAP
MAB_4377c|M.abscessus_ATCC_199 GDRVGIWAPNCAEWVLVQYATAKIGAILVNINPAYRTHELAYALNQSGVR
MMAR_4026|M.marinum_M AAHVGLLYPNGSDFVIGMLAAARIGAVVIPISTFVTPRELHEQLVDSDTQ
MAV_1579|M.avium_104 GTHVGLLHPNGARFVVAMLAAARIGAVVVPFSTFVTVRELREQLLDSDVE
Mflv_4363|M.gilvum_PYR-GCK GSHVGILYPNGAQWVVAMLAAARIGAVVVPFSTFSTAVELRRQLRDSDVG
Mvan_1981|M.vanbaalenii_PYR-1 GTHVGLLYPNSAEFVVAMLAATRIGAVVVPFSTFGTAPEVRRQLVDSDVS
MSMEG_2216|M.smegmatis_MC2_155 GTHVGVLYPNGADFVVAMLAVARVGAVVVPFSTFLTEAELRVQLLDSDVS
TH_3971|M.thermoresistible__bu GVRVGILAPNGPDFVTAFLATARIGAVAVPINTFFQPPELEWVLRDADIH
MLBr_02546|M.leprae_Br4923 GDGIAILARNHRWFVIANYGCARVGARIILLNSEFSGPQIKEVSEREGAK
. :.: * :* . : ** : :.. :
Mb3591|M.bovis_AF2122/97 VLFAAGLFLGADRAAGLDRAALPALRHVVRVPVEADDGTWDEFIATGAGA
Rv3561|M.tuberculosis_H37Rv VLFAAGLFLGADRAAGLDRAALPALRHVVRVPVEADDGTWDEFIATGAGA
MUL_4126|M.ulcerans_Agy99 VLFAMGHFLGSDRVAGLDRKALPALRHIVRIPIEEPDGTWDEFIETGT-D
MAB_4377c|M.abscessus_ATCC_199 TLICAKAFKSSDYVA-MASQVMPDAPGLRDVVFIGTSDWTELVAGAERVT
MMAR_4026|M.marinum_M ILLSADTFRSHDYAGRLRQLLGDTGFDGEDRLFSRAIPQLR-TAWVSYRR
MAV_1579|M.avium_104 ILLSARSFRPHDYARRLSEAVSETDFDPGRRLFCTAAPQLRRVLFAPQTV
Mflv_4363|M.gilvum_PYR-GCK VLLATRAFRTHDYVRALGEAVGVPLDDG--PLLSAEVPVLRHVVFD---A
Mvan_1981|M.vanbaalenii_PYR-1 VLLAARSFRSHDYVQTLTDAVGARPTHG--PVFSTAAPVLRHVLFDDQDS
MSMEG_2216|M.smegmatis_MC2_155 IMLSARSFRSHDYVGQISRVR-------------ADAPCLRHVVFEIPAA
TH_3971|M.thermoresistible__bu TLLAVETLLGRDMFERIEAAAGEWQVVDG-QLRIERLPQLRNILPLGTAR
MLBr_02546|M.leprae_Br4923 VIIYDDEYT--KVVSKAEPALGKLRALGVNPDEEEPPGSTDETLAELIAR
:: .
Mb3591|M.bovis_AF2122/97 LDAV--------------------AARAAAVAPQDVSDILFTSGTTGRSK
Rv3561|M.tuberculosis_H37Rv LDAV--------------------AARAAAVAPQDVSDILFTSGTTGRSK
MUL_4126|M.ulcerans_Agy99 TGAV--------------------TARAAAVSPDDVSDILFTSGTTGRSK
MAB_4377c|M.abscessus_ATCC_199 ETAL--------------------RARMSQLSNTDPINIQYTSGTTGYPK
MMAR_4026|M.marinum_M GAPRRTRSIECVYRLSQTIDPTMLRALEDDVDGSDVLAIVYTSGTTSAPK
MAV_1579|M.avium_104 GAP------------GGGIDPALLAAMEDDVQACDPLAIVYTSGSTSTPK
Mflv_4363|M.gilvum_PYR-GCK ECG-------------GAAD---VSALEGDVDGSDVLAIIYTSGSTSDPK
Mvan_1981|M.vanbaalenii_PYR-1 DAR-------------GRVDDALLRAMEDDVDGCDPLAVIYTSGSTSAPK
MSMEG_2216|M.smegmatis_MC2_155 GDP------------------ERRAGLEADVEGSDVLAIIYTSGSTGAPK
TH_3971|M.thermoresistible__bu REWP--------SSWPDPVPENFRKACEATVRSADDLLVIYTSGSTSTPK
MLBr_02546|M.leprae_Br4923 SSS-----------------------APAPKVRKRASIIILTSGTTGTPK
: ***:*. .*
Mb3591|M.bovis_AF2122/97 GVLCAHRQSLSASASWAANGKITSDDRYLCINPFFHNFGYKAGILACLQT
Rv3561|M.tuberculosis_H37Rv GVLCAHRQSLSASASWAANGKITSDDRYLCINPFFHNFGYKAGILACLQT
MUL_4126|M.ulcerans_Agy99 GVLCAHRQSLSASASWAANGKITADDRHLCINPFFHNFGYKAGILACLQT
MAB_4377c|M.abscessus_ATCC_199 GATLSHRNVLNNGFFVAESIQLQAGDRLCIPVPFYHCFGMVMGNLGCTTH
MMAR_4026|M.marinum_M GVVHTHSALVRHQQNLNVIRGLGTDDKLFCNSPFCWIGGFAFGLLATLLA
MAV_1579|M.avium_104 GVVHTHGALLEHQRNLNGIRGLTADDRLFCNSPFFWIGGFAFGLLATLVA
Mflv_4363|M.gilvum_PYR-GCK GVVHTHTSLLAHQRGLNEIRGLTAEDRLFCNSPFFWIGGFAFGLLATLVA
Mvan_1981|M.vanbaalenii_PYR-1 GVVHTHAALLAHQRSLNEIRRLTADDRLFCNSPFFWIGGFAFGLLATLVA
MSMEG_2216|M.smegmatis_MC2_155 GVVHTHSSLLAHQRDLNVLRGLTADDKLFCNSPFFWVGGLAFALLASMIA
TH_3971|M.thermoresistible__bu GIIHTHGTTITHSRFIATAHDWDHNDRIYVPMVFFWVAGLVFGFLGPMQV
MLBr_02546|M.leprae_Br4923 GANRNTPASLAPLGGILSKVPFRAHEVTLLPAPMFHALGYLHATLAMFLG
* : : : * . *.
Mb3591|M.bovis_AF2122/97 GATLIPHVT-FDPLHALRAIERHRITVLPGPPTIYQSLLDHPA--RKDFD
Rv3561|M.tuberculosis_H37Rv GATLIPHVT-FDPLHALRAIERHRITVLPGPPTIYQSLLDHPA--RKDFD
MUL_4126|M.ulcerans_Agy99 GATLFPHLT-FDPLRTLQAIERHRITVLPGPPTIYQTLLDHPA--RDDYD
MAB_4377c|M.abscessus_ATCC_199 GATIVMPAPGFDPGRTLEAIERERCVGVYGVPTMFIAMLADPG--FAHRD
MMAR_4026|M.marinum_M GSTLV-CSNA-DAATTLDLLEREKPTMTNGFASTVARLANHPS--FGRRD
MAV_1579|M.avium_104 GSTLI-CSNATDAGATLDLLEAEKPTMTNGFSAGIAHLAEHPS--FADRD
Mflv_4363|M.gilvum_PYR-GCK GSTLI-CSTASDAGRTLDLLEAEKPTMTNGFVAGITHLTRHPS--FARRD
Mvan_1981|M.vanbaalenii_PYR-1 GATLI-CSNATDAADTLDLLEAEKPTVTNGFVAGITHLPRHPS--FARRD
MSMEG_2216|M.smegmatis_MC2_155 GATLV-CSNSTDAGATFDLLEAEKPTITNGFVAGIAHLTRHPS--FPHRN
TH_3971|M.thermoresistible__bu GAAIL-TEHKFDAGEVLRLLQSEKATYTTGFGHIGPALVNHPD--FASTD
MLBr_02546|M.leprae_Br4923 STLVL--RRRFKPATVLEDIEKHQATAMVVVPVMLSRILDTLENLETKSD
.: :. .. .: :: .: . : :
Mb3591|M.bovis_AF2122/97 LSSLRFAVTGAATVPVVLVERMQSELDIDIVLTAYGLTEANGMGTMCRPE
Rv3561|M.tuberculosis_H37Rv LSSLRFAVTGAATVPVVLVERMQSELDIDIVLTAYGLTEANGMGTMCRPE
MUL_4126|M.ulcerans_Agy99 LSSLRFAVTGAATVPVVLVERMQSELDIDIVLTAYGLTEANGMGTMCRAD
MAB_4377c|M.abscessus_ATCC_199 LSTLRTGIMAGSVCPVEVMKRCIDEMHMAGVAIAYGMTETSPVSCQTLFD
MMAR_4026|M.marinum_M LSSMRRGNLYPIMAPEARPV------DPELRHNMLGMTEAGSIVLISADE
MAV_1579|M.avium_104 LSSMRRGNLYPIMAVEARPA------DPELRHNMLGMTEAGGVVLIGDDE
Mflv_4363|M.gilvum_PYR-GCK LSSMRRGNLYSIMAPDVRPA------DPELRHNMLGMTEAGSVVLLSGDE
Mvan_1981|M.vanbaalenii_PYR-1 LSSMRRGNLYPIMAAGARPA------DAELRHNMLGMTETGSVVLLSGDD
MSMEG_2216|M.smegmatis_MC2_155 LSSIRRGNLYPLMAPDVRPA------DPDLRHNMLGSTESGSVVLLDPDD
TH_3971|M.thermoresistible__bu LSSLREGYQQVLLPPERRTP------DPSLRVAQLGMTETCSSHTWWPPH
MLBr_02546|M.leprae_Br4923 LSSLRVVFVSGSQLGAELATR----ALEELGPVIYNMYGSTEIAFATIAG
**::* . :
Mb3591|M.bovis_AF2122/97 DD-AVTVATTCGRPFADFELRIADD-----------GEVLLRGPNVMVGY
Rv3561|M.tuberculosis_H37Rv DD-AVTVATTCGRPFADFELRIADD-----------GEVLLRGPNVMVGY
MUL_4126|M.ulcerans_Agy99 DD-ALTVATTCGRPFADFELRIGPDT----------GEVLLRGPNVMLGY
MAB_4377c|M.abscessus_ATCC_199 DD-LDRRTATVGRAHPHIEIKIVDPNSGETVQRGQSGELCTRGYSVMLGY
MMAR_4026|M.marinum_M SDQPESRRGSFGKPAPGFDTIIIEPGTGEVANVGQVGELCIRGPFVMQGY
MAV_1579|M.avium_104 ADQPEHRRGSFGKPAPGFEARILDPDTGAAVAVGEVGELCIRGPYLMQRY
Mflv_4363|M.gilvum_PYR-GCK SDQPEARRGSYGFLAPGFDARVVDPDTGSDTDG-AVGELVLRGPHLMQRY
Mvan_1981|M.vanbaalenii_PYR-1 SDQPESRRGSFGFLAPGFQARVVDPDTGCDVAVSTPGVLLLRGPFLMQGY
MSMEG_2216|M.smegmatis_MC2_155 TDQPEHRRGSFGRPAPGFETKVLD-----------SGELCIRGPYLMQGY
TH_3971|M.thermoresistible__bu EELPEAKRGSLGVSAPGYEHKIVD-EAGNEVPNGVTGEICVRGTAMMRAM
MLBr_02546|M.leprae_Br4923 PKDLQINSATVGPVVKGVKVKILDDS-GKEVPRGQVGRIFVGNAFPFEGY
. : * . : * : . :
Mb3591|M.bovis_AF2122/97 LDDTEATAAAIDADGWLHTGDIGAVDQAGNLRINDRLKDMYICGGFNVYP
Rv3561|M.tuberculosis_H37Rv LDDTEATAAAIDADGWLHTGDIGAVDQAGNLRITDRLKDMYICGGFNVYP
MUL_4126|M.ulcerans_Agy99 LDDPRATAAAIDADGWLHTGDIGVLDEAGNLRITDRLKDMYICGGFNVYP
MAB_4377c|M.abscessus_ATCC_199 WNDEAHTREVLDTDGWMHTGDLAVMRDDGYCTIIGRLKDMVIRGGENIYP
MMAR_4026|M.marinum_M YK--RSREECFDADGWFHTGDLVRADQDGYMYFTGRLSSLIKTAGANVSP
MAV_1579|M.avium_104 HK--RSREECFDPDGWFHTGDLVRADADGYFYFAGRLGAMIKTAGANVSA
Mflv_4363|M.gilvum_PYR-GCK YG--RSREECFDADGWFHTGDLVRRDDDGVFYFVGRAGSMIKTAGANVAP
Mvan_1981|M.vanbaalenii_PYR-1 YG--RAREDCFDGDGWFDTGDLVRRDGDGVFYFIGRTGTMIKTAGANVAP
MSMEG_2216|M.smegmatis_MC2_155 YG--RSREECFDTDGWFHTGDLVRVDDDGYFYFLGRAGAMIKTAGANVTP
TH_3971|M.thermoresistible__bu VG--RHWFELVDRDGWLHTKDAGYRDDDGHLYFAGRLDEMIKTSGTNVAP
MLBr_02546|M.leprae_Br4923 TG----GGGKQIIDGLLSSGDVGYFDEHDLLYISGRDDEMIVSGGENVFP
** : : * . : .* : .* *: .
Mb3591|M.bovis_AF2122/97 AEVEQVLARMDG-----VADAAVIGVPDQRLGEVGRAFVVARPG-TGLDE
Rv3561|M.tuberculosis_H37Rv AEVEQVLARMDG-----VADAAVIGVPDQRLGEVGRAFVVARPG-TGLDE
MUL_4126|M.ulcerans_Agy99 AEVEQVLARLDG-----VADVAVIGIPDHRLGEVGRAFIVARPG-FNLDE
MAB_4377c|M.abscessus_ATCC_199 REIEEFLLTHPD-----IEDVHVVGVPDEKYGEELCAWVRMRPDRVVIDA
MMAR_4026|M.marinum_M AEVERAIAKLG-------MVAHVVGIPDPQRGQVVAAVLVVADGVGALDE
MAV_1579|M.avium_104 VEVEKAIAAVTG-----GATAYVVGIPDARRGQLVAAAVVWPDDRAALDP
Mflv_4363|M.gilvum_PYR-GCK AEVEKALSAALQAV-DAGVAVHVVGLPDPERGQIVAAVIATDNG-TVFDE
Mvan_1981|M.vanbaalenii_PYR-1 GEVEKAIIAVIP---DPDVVVHVVGLPDAERGQLVAAVIASD---TEVDV
MSMEG_2216|M.smegmatis_MC2_155 DEVQKALQHVLEGRDMRDVTVQVVGLPDQERGQLVAAVVATADP-AAFDE
TH_3971|M.thermoresistible__bu MEVEAALGKIEAVR-----IAYVVGVPDPEKGAIVSAAVVLNEG-YTATA
MLBr_02546|M.leprae_Br4923 AEVEDLISGHPE-----VVEATAIGVDDKEWGARLRAFVVKKQD-ATIDE
*:: : . .:*: * . * * :
Mb3591|M.bovis_AF2122/97 ASVIAYTREHLANFKTPR---SVRFVDVLPRNAAGKVSKPQLRELG----
Rv3561|M.tuberculosis_H37Rv ASVIAYTREHLANFKTPR---SVRFVDVLPRNAAGKVSKPQLRELG----
MUL_4126|M.ulcerans_Agy99 KSVIDYTREHLANFKAPR---SVRFVDTLPRNAGGKVVKPQLRELA----
MAB_4377c|M.abscessus_ATCC_199 VAIRAFASGRLAHYKIPR---YVHVVESFPMTVTGKVRKIEMRQQTIQIF
MMAR_4026|M.marinum_M LALRERLETELSAYKIPTRFATLPPSE-IPLLSSGKVDTHQLKKCFDA--
MAV_1579|M.avium_104 DALRERLKSELSAYKIPRRFASLRRAD-VPLLSSGKVDLRQLRKLFDA--
Mflv_4363|M.gilvum_PYR-GCK PAVKEALSTQVSAYKIPRRVLSLRHTE-IPTMSSGKIDLAALRRLFDD--
Mvan_1981|M.vanbaalenii_PYR-1 SGLQETLRSHLSAYKIPRRVATVRHAD-IPMLSSGKVDLSALRRLFGALR
MSMEG_2216|M.smegmatis_MC2_155 AAVRAALRAQLSSYKVPRRFAVIHSDE-LPVKSSGKIDVAALRELFDD--
TH_3971|M.thermoresistible__bu DDLVAECRSRLAAYKVPKKWAILSDADRLPYTTTNKIDKVRLTQLMASGE
MLBr_02546|M.leprae_Br4923 DAIKAYVRDHLARYKVPR---EVIFLEELPRNPTGKVLKRELRDFEVH--
: .:: :* * : : .* .*: :
Mb3591|M.bovis_AF2122/97 -----------
Rv3561|M.tuberculosis_H37Rv -----------
MUL_4126|M.ulcerans_Agy99 -----------
MAB_4377c|M.abscessus_ATCC_199 GLPEPGRTDEQ
MMAR_4026|M.marinum_M -----------
MAV_1579|M.avium_104 -----------
Mflv_4363|M.gilvum_PYR-GCK -----------
Mvan_1981|M.vanbaalenii_PYR-1 -----------
MSMEG_2216|M.smegmatis_MC2_155 -----------
TH_3971|M.thermoresistible__bu LC---------
MLBr_02546|M.leprae_Br4923 -----------