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NFAVLPPEINSVRMFSGAGSEPMLAAAAAWDGLSAELGEAAESFASVTSGLAGAGQAWQGAAASAMVAAA GPYASWLGAAAARAAGASASAKVVASAFEAARAAMVHPLAVAANRNGFVQLVMSNLFGQNAPAIAAAEGV YEQMWAADVAAMAGYHGGASAAAAQLSSWQGMVSGVLSGVPGVSGLVGGAAPAAAAVTTPLAGAAQAVAS QAASVVPAPLQGINLGFGNIGSLNLGSGNIGDGNLGSGNIGNINFGSGNIGGTNLGGGNQGDFNLGSGNI GNLNLGSGNFGSQNLGSGNIGSINFGVGNIGNTNIGSGNIGDTNFGSGNIGSLNFGSGNSGSNNIGFGNF GSSNFGFGNTGNNNIGFGLTGDGQFGIGGLNSGSGNIGLFNSGDNNIGFFNSGSGNLGFGNAGNSNTGFG NAGDVNTGFWNGGSINTGVGHAGATNFGFFDSGNYNAGSFNAGNSNTSFGNSGDVNTGFLNAGNINSGFG NAGNVNTGWANAGDINTGGFNGGVLNTGFFSATTHAGPNSGYFNVGTGNSGFGHNDPSGSGNSGLQNSGF GNSGYVNTSTTSTFGGNSGALDTGYGNAGFYNAAVQNAGFVIAGVNTSGILSSGTGSSGLLVFGDGLSGF FKNVL*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_3665 | - | - | 100% (636) | PPE family protein |
| M. marinum M | MMAR_3666 | - | 0.0 | 72.23% (641) | PPE family protein |
| M. marinum M | MMAR_4319 | - | 0.0 | 58.19% (641) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2377c | PPE40 | 0.0 | 66.25% (634) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_5091 | - | 1e-28 | 28.12% (633) | triple helix repeat-containing collagen |
| M. tuberculosis H37Rv | Rv2356c | PPE40 | 0.0 | 66.25% (634) | PPE family protein |
| M. leprae Br4923 | MLBr_01182 | - | 3e-28 | 39.77% (176) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_4284c | - | 1e-22 | 28.41% (535) | hypothetical protein MAB_4284c |
| M. avium 104 | MAV_4704 | - | 4e-48 | 50.24% (207) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0868 | - | 1e-24 | 26.32% (680) | hypothetical protein MSMEG_0868 |
| M. thermoresistible (build 8) | TH_3113 | - | 1e-23 | 41.25% (160) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_0964 | - | 0.0 | 57.41% (641) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_1264 | - | 3e-29 | 27.32% (626) | triple helix repeat-containing collagen |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2377c|M.bovis_AF2122/97 --------------------------------------------------
Rv2356c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_3665|M.marinum_M --------------------------------------------------
MUL_0964|M.ulcerans_Agy99 --------------------------------------------------
MAV_4704|M.avium_104 --------------------------------------------------
MLBr_01182|M.leprae_Br4923 --------------------------------------------------
TH_3113|M.thermoresistible__bu --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0868|M.smegmatis_MC2_155 MHERLRERAGGVRKTLSDFAEGAGLKPSDTDDTRSPLRKPKFPAALAPES
MAB_4284c|M.abscessus_ATCC_199 --------------------------------------------------
Mb2377c|M.bovis_AF2122/97 --------------------------------------------------
Rv2356c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_3665|M.marinum_M --------------------------------------------------
MUL_0964|M.ulcerans_Agy99 --------------------------------------------------
MAV_4704|M.avium_104 --------------------------------------------------
MLBr_01182|M.leprae_Br4923 --------------------------------------------------
TH_3113|M.thermoresistible__bu --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1264|M.vanbaalenii_PYR-1 -------------------MMFLAPPGGPGPISAAIQLTSTGSEATEP--
MSMEG_0868|M.smegmatis_MC2_155 PLPDLKPRWERPTTAPDSETPSITQPQGRDTAADPAEQQATSTNTTDQPT
MAB_4284c|M.abscessus_ATCC_199 --------------------------------------------------
Mb2377c|M.bovis_AF2122/97 --------------------------------------------------
Rv2356c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_3665|M.marinum_M --------------------------------------------------
MUL_0964|M.ulcerans_Agy99 --------------------------------------------------
MAV_4704|M.avium_104 --------------------------------------------------
MLBr_01182|M.leprae_Br4923 --------------------------------------------------
TH_3113|M.thermoresistible__bu --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK --------------------------------------MVTFGGGATPTP
Mvan_1264|M.vanbaalenii_PYR-1 ------------------------------------WYVVSFGGSGAPTP
MSMEG_0868|M.smegmatis_MC2_155 SDSLGAQPTAQVARQVQAPATDPAPAAPSLRPISGLLSVVTLGTTLIPNA
MAB_4284c|M.abscessus_ATCC_199 ------------------------------------MSIIDFILNLFRDP
Mb2377c|M.bovis_AF2122/97 --------------------------------------------------
Rv2356c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_3665|M.marinum_M --------------------------------------------------
MUL_0964|M.ulcerans_Agy99 --------------------------------------------------
MAV_4704|M.avium_104 --------------------------------------------------
MLBr_01182|M.leprae_Br4923 --------------------------------------------------
TH_3113|M.thermoresistible__bu --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK ----------------------------------------TSLGAAAVDL
Mvan_1264|M.vanbaalenii_PYR-1 ----------------------------------------NNLAASLVDL
MSMEG_0868|M.smegmatis_MC2_155 PTEPADMPGVWAVMAWARRQPMYSDPAMRTTVNPQAQLPVPTVASAVLDP
MAB_4284c|M.abscessus_ATCC_199 ----------------------------------------VEAASYVADP
Mb2377c|M.bovis_AF2122/97 -----------------------------------MVN--FSVLPPEINS
Rv2356c|M.tuberculosis_H37Rv -----------------------------------MVN--FSVLPPEINS
MMAR_3665|M.marinum_M ------------------------------------MN--FAVLPPEINS
MUL_0964|M.ulcerans_Agy99 ------------------------------------MN--FMMLPPEVNS
MAV_4704|M.avium_104 -----------------------------------MTNPHFAWLPPEVNS
MLBr_01182|M.leprae_Br4923 -----------------------------------MFD--FAALSPETNS
TH_3113|M.thermoresistible__bu -----------------------------------------MALPPEVHS
Mflv_5091|M.gilvum_PYR-GCK S------------------------GTSCG----------LICNGQDGTG
Mvan_1264|M.vanbaalenii_PYR-1 S------------------------GTSCG----------LICNGQDGTG
MSMEG_0868|M.smegmatis_MC2_155 TQIVNWLIYQPLHAAGQQFWVVSPIGSTLGGVINTISGQYLIGNGINGTA
MAB_4284c|M.abscessus_ATCC_199 -------------------------------------EAALANAGLSAVS
. .
Mb2377c|M.bovis_AF2122/97 GRMFFGAGSGPMLAAAAAWDGLAAELGLAA--ESFGLVTSGLAGGSGQAW
Rv2356c|M.tuberculosis_H37Rv GRMFFGAGSGPMLAAAAAWDGLAAELGLAA--ESFGLVTSGLAGGSGQAW
MMAR_3665|M.marinum_M VRMFSGAGSEPMLAAAAAWDGLSAELGEAA--ESFASVTSGLAG-AGQAW
MUL_0964|M.ulcerans_Agy99 ALMFTGAGSAPTLAAATAWDGLVAELGEAA--EAFSSVTSGLAS---GSW
MAV_4704|M.avium_104 ALIYSGPGPGPLLAAAAAWDGLAEELASSA--QSFSSVTSDLAS---GSW
MLBr_01182|M.leprae_Br4923 TRMYLGPGSSPILTAAAAWVVLAKELTAAA--QGLQSAVEALLT----TF
TH_3113|M.thermoresistible__bu TLLRTGPGPGALSAAADAWRMLSDEYRAAA--VELAAVVSQTCA---TAW
Mflv_5091|M.gilvum_PYR-GCK QN-----GGILFGNGGSGWNSDVVGMDGGN--GGNGGLFGGNGGNGGNGL
Mvan_1264|M.vanbaalenii_PYR-1 QN-----GGILFGNGGSGWNSEIAGVSGGN--GGNAGLFGGNGGNGGNGL
MSMEG_0868|M.smegmatis_MC2_155 DNPNGGTGGLLFGDGGHGYDGSAAGLAGGN--GGNAGLFG-NGGNGGVGW
MAB_4284c|M.abscessus_ATCC_199 AAQVGAVMPVVAESVASNYGYQSQWVNTGNPIHDLSGNLQNYYAAQPDGP
. : .
Mb2377c|M.bovis_AF2122/97 QGAAAAAMVVAAAPYAGWLAAAAARAGGAAVQAKAVAG-----AFEAARA
Rv2356c|M.tuberculosis_H37Rv QGAAAAAMVVAAAPYAGWLAAAAARAGGAAVQAKAVAG-----AFEAARA
MMAR_3665|M.marinum_M QGAAASAMVAAAGPYASWLGAAAARAAGASASAKVVAS-----AFEAARA
MUL_0964|M.ulcerans_Agy99 QGPAAAAMAAAAAPYAGWLSAAATRALGAATQAKAAAA-----VFESAQA
MAV_4704|M.avium_104 QGASSAAMMTVANQYVSWLSAAAAQAEEVSHQASAIAT-----AFEVALA
MLBr_01182|M.leprae_Br4923 EGESAAALAERVTPYEKWLTQNAASAELTATQLTVAAN-----AYETAFT
TH_3113|M.thermoresistible__bu EGVGADAYAAAHGPYLFWLTDTAAAAAAAGAQLEAAAA-----AHASALA
Mflv_5091|M.gilvum_PYR-GCK GGGNGGNGGNAGAFALFGNGGNGGNGGVGVVGATGAVG--APGVAGATGA
Mvan_1264|M.vanbaalenii_PYR-1 GSGDGGNGGDAGLFSLFGRGGNGGNGGVGIAGATGAVG--APGVAGATGA
MSMEG_0868|M.smegmatis_MC2_155 AGLDGGNGGSGG--LLMGIGGAGGAGGVGADGTSAHVDGGTGGTGGTGGG
MAB_4284c|M.abscessus_ATCC_199 SILSPSLLSPRDNDFLSHNDTDFASHNPIASGNQVMSP------SGNVDS
Mb2377c|M.bovis_AF2122/97 AMVDPVVVAANRSAFVQLVLSNVFGQNAPAIAAAEAT-------------
Rv2356c|M.tuberculosis_H37Rv AMVDPVVVAANRSAFVQLVLSNVFGQNAPAIAAAEAT-------------
MMAR_3665|M.marinum_M AMVHPLAVAANRNGFVQLVMSNLFGQNAPAIAAAEGV-------------
MUL_0964|M.ulcerans_Agy99 ATVHPELVLANRNQLVSLVLSNLFGQNAPAIAATEST-------------
MAV_4704|M.avium_104 ATVQPAVVAANRALVQALAATNWLGQNTPAIADIEAA-------------
MLBr_01182|M.leprae_Br4923 MTVPPLMVFVNRAQACLLIMSNIFGQNSTAIAEKEAE-------------
TH_3113|M.thermoresistible__bu AMPTMAELTANRTTHAALVATNFFGVNTIPIAVNEAD-------------
Mflv_5091|M.gilvum_PYR-GCK TGVTSGVVGGNGEDAVGYGATGAAGAAGAAGAAGAAG-------------
Mvan_1264|M.vanbaalenii_PYR-1 TGVTSNVTGGNGADAVGYGATGAAGAAGAAGAAGKAG-------------
MSMEG_0868|M.smegmatis_MC2_155 TGGTGGIGGTGGGLFGLLGHSGSTGAAGAAGNGGDGGNGGFGYVLIAGPN
MAB_4284c|M.abscessus_ATCC_199 FNRGPLLDLSFGDLQFGNRDTTAIGDGAVAVGGSNSG-------------
: * . .
Mb2377c|M.bovis_AF2122/97 --YEQMWAADVAAMVGYHGGAS-AAAALAPWQ------------------
Rv2356c|M.tuberculosis_H37Rv --YEQMWAADVAAMVGYHGGASAAAAALAPWQ------------------
MMAR_3665|M.marinum_M --YEQMWAADVAAMAGYHGGASAAAAQLSSWQGMVSG-------------
MUL_0964|M.ulcerans_Agy99 --YEELWAQDVAATVGYHGGASAVAAQLAPWQQ-----------------
MAV_4704|M.avium_104 --YEQMWASDVAAMFGYHADASAAVAKLPPWN------------------
MLBr_01182|M.leprae_Br4923 --YTEMWIQDAAAMTSYQASVLEAVGATKAFTAP----------------
TH_3113|M.thermoresistible__bu --YARMWIQAATTMATYEAVASAAVSATPRTVAP----------------
Mflv_5091|M.gilvum_PYR-GCK -AVGSAGAAGEAGETGTWG--NAGLPGKAGDAGGAG--------------
Mvan_1264|M.vanbaalenii_PYR-1 -AVGSAGTAGSAGAPGVWG--NAGLPGAAGAAGGAG--------------
MSMEG_0868|M.smegmatis_MC2_155 VTVGSETRGGTGGAGGTGGQSTAAGPGKGGGGGGGGGGAILIGANGGTVD
MAB_4284c|M.abscessus_ATCC_199 ---PIASGQGSTAVNGDVRDSNIINADHGSNVG-----------------
Mb2377c|M.bovis_AF2122/97 ---------------QAVPGLSGLLGGAA-----------------NAPA
Rv2356c|M.tuberculosis_H37Rv ---------------QAVPGLSGLLGGAA-----------------NAPA
MMAR_3665|M.marinum_M -------------VLSGVPGVSGLVGGAA-----------------PAAA
MUL_0964|M.ulcerans_Agy99 -------------AIQALPGRVAAMATTG-----------------PAAS
MAV_4704|M.avium_104 --------------------------------------------------
MLBr_01182|M.leprae_Br4923 --------------------------------------------------
TH_3113|M.thermoresistible__bu ------------------PPILGAGTGES-----------------ATAA
Mflv_5091|M.gilvum_PYR-GCK --AVGAAGAAG------TVGTAGATGGTG---------------TGANGG
Mvan_1264|M.vanbaalenii_PYR-1 --AIGTAGVAG------AAGTAGATGGTG---------------VGGNGG
MSMEG_0868|M.smegmatis_MC2_155 GHAIGGNGGNGGNGSTTAAGGNGGTGGTGRVIAEGTGSTAEGTATGGDGG
MAB_4284c|M.abscessus_ATCC_199 -----------------VDQSQTRVGGDYT----------------NVSG
Mb2377c|M.bovis_AF2122/97 AAAQ---GAAQGLAELT----------LNLGVGNIGSLNLGSGNIGGTNV
Rv2356c|M.tuberculosis_H37Rv AAAQ---GAAQGLAELT----------LNLGVGNIGSLNLGSGNIGGTNV
MMAR_3665|M.marinum_M AVTTPLAGAAQAVASQAASVVPAPLQGINLGFGNIGSLNLGSGNIGDGNL
MUL_0964|M.ulcerans_Agy99 AAAALASGPAAALDIGNNG------SGNFLSIGNIGNNNLGSGNTGSANL
MAV_4704|M.avium_104 --------------------------------------------------
MLBr_01182|M.leprae_Br4923 --------------------------------------------------
TH_3113|M.thermoresistible__bu ITGAHVTAELRAAESR--------------------------TLLDEINE
Mflv_5091|M.gilvum_PYR-GCK AGGVGGVGGTGAAG--------------AAGGAGGLGETGTTGGAGGVGG
Mvan_1264|M.vanbaalenii_PYR-1 AGQAGGIGGTGAAG--------------AAGQAGTAGETGVTGGVGGIGG
MSMEG_0868|M.smegmatis_MC2_155 HSTGTGIGGNGGIGSVYAYGNNGAVSGTATGGRGGDGIDGGTGGAGGMGE
MAB_4284c|M.abscessus_ATCC_199 HGSADIDKSVTVVDDHS--------------QRNTTNINDSFNTDRSTNI
Mb2377c|M.bovis_AF2122/97 GSGNVGGTNLGSGNYGSLNWGSGNTGTGNAG-------------------
Rv2356c|M.tuberculosis_H37Rv GSGNVGGTNLGSGNYGSLNWGSGNTGTGNAG-------------------
MMAR_3665|M.marinum_M GSGNIGNINFGSGNIGGTNLGGGNQGDFNLG-------------------
MUL_0964|M.ulcerans_Agy99 GGGNIGNGNLGSGNTGNVNLGNGNNGFFNFG-------------------
MAV_4704|M.avium_104 --------------------------------------------------
MLBr_01182|M.leprae_Br4923 --------------------------------------------------
TH_3113|M.thermoresistible__bu LIDRLFAPLFPPGFADALPDGLLGTLLAPLL-------------------
Mflv_5091|M.gilvum_PYR-GCK Q--GTAGGTGGVGGIGGAGSTGAVGGVGGKG----IQGGQG---------
Mvan_1264|M.vanbaalenii_PYR-1 Q--GTEGGTGGVGGVGGVGATGGAGGVGGKG----IQGGQG---------
MSMEG_0868|M.smegmatis_MC2_155 IYSGADGEATGISAGGDGGSATGADSLGGRGGTSWVQAGYGPTTGGKASG
MAB_4284c|M.abscessus_ATCC_199 GSGNTTNTEIGSHNQANIGTSTSAGGSAAVG-------------------
Mb2377c|M.bovis_AF2122/97 ------SGNTGDYNPGSGNFGSGNFGS-----------------------
Rv2356c|M.tuberculosis_H37Rv ------SGNTGDYNPGSGNFGSGNFGS-----------------------
MMAR_3665|M.marinum_M ------SGNIGNLNLGSGNFGSQNLGS-----------------------
MUL_0964|M.ulcerans_Agy99 ------NGNLGDTNFGSGNSGNLNLGS-----------------------
MAV_4704|M.avium_104 --------------------------------------------------
MLBr_01182|M.leprae_Br4923 --------------------------------------------------
TH_3113|M.thermoresistible__bu ------PGATGDGPPMATIMSFLLMGL-----------------------
Mflv_5091|M.gilvum_PYR-GCK ----LQGGKGGDGGAGGKGGDADSMGS------------------AGATG
Mvan_1264|M.vanbaalenii_PYR-1 ----LQGGQGGDGGTGGTGGDATSMGE------------------AGATG
MSMEG_0868|M.smegmatis_MC2_155 TAKAGHGGKASDGGKGGNGGDALVMAAGATGVATGNTAIGGNGGAASANG
MAB_4284c|M.abscessus_ATCC_199 -------GNAGLAGNAGLAGNAGLAGN-----------------------
Mb2377c|M.bovis_AF2122/97 --------------------------------------------------
Rv2356c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_3665|M.marinum_M --------------------------------------------------
MUL_0964|M.ulcerans_Agy99 --------------------------------------------------
MAV_4704|M.avium_104 --------------------------------------------------
MLBr_01182|M.leprae_Br4923 --------------------------------------------------
TH_3113|M.thermoresistible__bu --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK GKGGNGGNGGRGGLFG---------------KGGNAGNGAD---------
Mvan_1264|M.vanbaalenii_PYR-1 GKGGNGGNGGRGSLFG---------------RGGNAGNGGN---------
MSMEG_0868|M.smegmatis_MC2_155 AVGGNGGFTNIAAIHGSITDSSATSGHGGAAQGGNGGNGGNGWVQAYDPN
MAB_4284c|M.abscessus_ATCC_199 --------------------------------------------------
Mb2377c|M.bovis_AF2122/97 --------------GN-IGSLNVGSGN-FGTLNLANGNNGDVNFGGGNTG
Rv2356c|M.tuberculosis_H37Rv --------------GN-IGSLNVGSGN-FGTLNLANGNNGDVNFGGGNTG
MMAR_3665|M.marinum_M --------------GN-IGSINFGVGN-IGNTNIGSGNIGDTNFGSGNIG
MUL_0964|M.ulcerans_Agy99 --------------GNRFGSGNIGFGNRFGDGNFGSGNAGSYNFGTGNNG
MAV_4704|M.avium_104 --------------------------------------------------
MLBr_01182|M.leprae_Br4923 --------------------------------------------------
TH_3113|M.thermoresistible__bu --------------SN----------------------------------
Mflv_5091|M.gilvum_PYR-GCK -------------GGTGGAGGAGGTGG-TGGAGGTGG-------------
Mvan_1264|M.vanbaalenii_PYR-1 -------------GGTGGNGGNGGTGG-TGGNGGTGG-------------
MSMEG_0868|M.smegmatis_MC2_155 GPAGTTIDKGKAAGGNGGDGGFNGTGGATGGRGGDGAGASVWKANGQHST
MAB_4284c|M.abscessus_ATCC_199 -------------AGLAGNAGLAGNAG-----------------------
Mb2377c|M.bovis_AF2122/97 DFNFGGGNNGTLNFGFGNTGSGNFGFGNTGNNNIGIGLTGDGQIGIGGLN
Rv2356c|M.tuberculosis_H37Rv DFNFGGGNNGTLNFGFGNTGSGNFGFGNTGNNNIGIGLTGDGQIGIGGLN
MMAR_3665|M.marinum_M SLNFGSGNSGSNNIGFGNFGSSNFGFGNTGNNNIGFGLTGDGQFGIGGLN
MUL_0964|M.ulcerans_Agy99 SFNIGSGNNGDSNIGFGNLGTNNLGFGNNGSNNIGFGLSGSNQIGIGGLN
MAV_4704|M.avium_104 --------------------------------------------------
MLBr_01182|M.leprae_Br4923 -----------------PLGVNEVGLAQEVVEEVVEEVVEEVVEAEQAIS
TH_3113|M.thermoresistible__bu ---------------PAYLFPVLVYLLFTGVVHTTVAVSGMLAQLVPLMP
Mflv_5091|M.gilvum_PYR-GCK ----TGGTGGIGGAGSTGGTGGTGGTGGTGGTGGTG-GTGGTGGTGGTGG
Mvan_1264|M.vanbaalenii_PYR-1 ----TGGTGGIGGAGSTGGTGGTGGTGGTGGTGGTG-GTGGTGGTGGTGG
MSMEG_0868|M.smegmatis_MC2_155 GQTDTGGNGGRGGDGGTFVNAGANGNGGAGGAGGVSEGEGGTGGHGGDGG
MAB_4284c|M.abscessus_ATCC_199 ----LAGNAGLAGNAGLAGNAGLAGNAGLAGNAGLAGNAGLAGNAGLAGN
Mb2377c|M.bovis_AF2122/97 SGTGNIGFGNSGNNNIGFFNSGDGNIGFFNSGD---------GNTGFGNA
Rv2356c|M.tuberculosis_H37Rv SGTGNIGFGNSGNNNIGFFNSGDGNIGFFNSGD---------GNTGFGNA
MMAR_3665|M.marinum_M SGSGNIGLFNSGDNNIGFFNSGSGNLGFGNAGN---------SNTGFGNA
MUL_0964|M.ulcerans_Agy99 AGIGNMGFGNAGDNNVGFFNSGSNNIGFFNSGD---------GNFGFAHA
MAV_4704|M.avium_104 --------------------EVLQNLGFSNAST---------AVTRPAGS
MLBr_01182|M.leprae_Br4923 QAALDQAVNEGMEATVVPQVDQQVNVDVATPQT---------AVP--DSS
TH_3113|M.thermoresistible__bu ALLPVAVAALGGLAGVWAGLSGLAGLAGLTAVP---------AADGGASA
Mflv_5091|M.gilvum_PYR-GCK KGGTGGTGGAGGTG----GDGGTGGTGGTGGTG---------GTGGTGGT
Mvan_1264|M.vanbaalenii_PYR-1 KGGTGGTGGDGGTG----GTGGTGGTGGTGGTG---------GTGGTGGT
MSMEG_0868|M.smegmatis_MC2_155 RGGDGALGGNGGTGGVGLGNGGKGGNGGNGGNGGTYVDPSHTGAGGNGGN
MAB_4284c|M.abscessus_ATCC_199 AGLAGNAGLAGNAG--LAGNAGLAGNAGLAGNAG------LAGNAGLAGN
. .
Mb2377c|M.bovis_AF2122/97 GNIN--------------------------TGFWNAGNLNTG--------
Rv2356c|M.tuberculosis_H37Rv GNIN--------------------------TGFWNAGNLNTG--------
MMAR_3665|M.marinum_M GDVN--------------------------TGFWNGGSINTG--------
MUL_0964|M.ulcerans_Agy99 GSTN--------------------------TGFWNSGGTNTG--------
MAV_4704|M.avium_104 GAVA--------------------------RGYTSR--------------
MLBr_01182|M.leprae_Br4923 SAAA--------------------------PQLWGG--------------
TH_3113|M.thermoresistible__bu APVP--------------------------AGGPSLPS------------
Mflv_5091|M.gilvum_PYR-GCK GGAG-----------DGTGGTGGTGG----TGGQGGQGGQGG--------
Mvan_1264|M.vanbaalenii_PYR-1 GGAG-----------DGLGGTGGTGG----TGGFGGQGGQGG--------
MSMEG_0868|M.smegmatis_MC2_155 GGAGRIRVNNGTATGTATGGNGGNGGNGDADGHRGGKGGDGGEALIRATV
MAB_4284c|M.abscessus_ATCC_199 AGLAG-------------------------NAAVAGNAAVAG--------
.
Mb2377c|M.bovis_AF2122/97 --------------------------------------------------
Rv2356c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_3665|M.marinum_M --------------------------------------------------
MUL_0964|M.ulcerans_Agy99 --------------------------------------------------
MAV_4704|M.avium_104 --------------------------------------------------
MLBr_01182|M.leprae_Br4923 --------------------------------------------------
TH_3113|M.thermoresistible__bu --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK ---------TGGTGGQGG-LGGGGGTG-----------------------
Mvan_1264|M.vanbaalenii_PYR-1 ---------TGGTGGQGG-LGGVGGTG-----------------------
MSMEG_0868|M.smegmatis_MC2_155 IGSNASGTATGGDGGNGGTLGATNGTGGAATIVAYNVVQANPQASGTATD
MAB_4284c|M.abscessus_ATCC_199 --------------------------------------------------
Mb2377c|M.bovis_AF2122/97 -FGSAGNGNVGIFDGGNSNSGSFNVGFQNTGFGNSGAGNTGFFNAGDSNT
Rv2356c|M.tuberculosis_H37Rv -FGSAGNGNVGIFDGGNSNSGSFNVGFQNTGFGNSGAGNTGFFNAGDSNT
MMAR_3665|M.marinum_M -VGHAGATNFGFFDSGNYNAGSFNAGNSNTSFGNSGDVNTGFLNAGNINS
MUL_0964|M.ulcerans_Agy99 -FGNGGSLNFGFGNGGVENMGHGNAGSFNMGFGNGGGGNTGFYNSGTYNT
MAV_4704|M.avium_104 --------------------------------------IAGFLAPRAPQ-
MLBr_01182|M.leprae_Br4923 -------------------------------FAQHLSPINDTLSMINNHA
TH_3113|M.thermoresistible__bu --------------------------------GSSAPPAPTGSAAPTTGT
Mflv_5091|M.gilvum_PYR-GCK GQGGTGGTGGQGGTGGTGGTGGTG--------GTGGAGGDGGLGGLGGFG
Mvan_1264|M.vanbaalenii_PYR-1 GTGGTGGTGGQGGTGGTGGTGGTG--------GTGGAGGDGGLGGLGGFG
MSMEG_0868|M.smegmatis_MC2_155 GHGGSGINGGHGGNGGQGTIEANGPSAVASGIGAGGNGGDGIDGGLGGNG
MAB_4284c|M.abscessus_ATCC_199 ----NAAVAGNAAVGGVLNTGVSGAIGGSSHVGGAINESLGGSGSVGGST
Mb2377c|M.bovis_AF2122/97 GFANAGNVNTGFFNGGDINTGGFNGGNVNTGFGSALTQAGAN-------S
Rv2356c|M.tuberculosis_H37Rv GFANAGNVNTGFFNGGDINTGGFNGGNVNTGFGSALTQAGAN-------S
MMAR_3665|M.marinum_M GFGNAGNVNTGWANAGDINTGGFNGGVLNTGFFSATTHAGPN-------S
MUL_0964|M.ulcerans_Agy99 GFSNAAETNTGWENSGNVNTGGYNSGGLNTGIGSPDTQAGPN-------S
MAV_4704|M.avium_104 --------------------------------------------------
MLBr_01182|M.leprae_Br4923 GMANAGLSLVNGMGSAMKSLAPTTTKAAESAFKAMG-SAVQS-------T
TH_3113|M.thermoresistible__bu APGGAGSPPPAGHSVPPAPHSAPPVGTSGPPYLIAAQPAPGV-------A
Mflv_5091|M.gilvum_PYR-GCK GSGGTGGQGGLGGPGGSTGGAGGAGG--QAGTAGKGGLFG----GSGSAG
Mvan_1264|M.vanbaalenii_PYR-1 GVGGTGGQGGQGGPGGSTGGAGGAGG--QAGVAGKGGLFG----GSGSAG
MSMEG_0868|M.smegmatis_MC2_155 GDGVVNTTANAANPGSATGTATGGDGGKATGTASQGGNGGPSWVQSGYGS
MAB_4284c|M.abscessus_ATCC_199 AVGGGAHTGVGGGVSTGVGVGSHVGGGISESLGGSGSVGGST--------
Mb2377c|M.bovis_AF2122/97 GFGNLGTGNSGWGNSDPSGTGNSGFFNT-----GNGNSGFSNAGPAMLPG
Rv2356c|M.tuberculosis_H37Rv GFGNLGTGNSGWGNSDPSGTGNSGFFNT-----GNGNSGFSNAGPAMLPG
MMAR_3665|M.marinum_M GYFNVGTGNSGFGHNDPSGSGNSGLQNS-----GFGNSGYVNTSTTSTFG
MUL_0964|M.ulcerans_Agy99 GFGHSGSGNSGFFN---SGDGNSGFENSNTCVSANGHSGVRNSGDAT---
MAV_4704|M.avium_104 --------------------------------------------------
MLBr_01182|M.leprae_Br4923 GRGLLGSSSGGHVTAQLGRAASIGSLRVP---QTWTTASQPVTAATRALS
TH_3113|M.thermoresistible__bu RRSAGARRAASIVEPAGSAAAAAAARESAPIRRRRGQKDGLHGHRHEHQQ
Mflv_5091|M.gilvum_PYR-GCK KAGATGAAGASGGKGAQGATGAQGATG------AQGATG-ATGAAGKAGA
Mvan_1264|M.vanbaalenii_PYR-1 TAGVTGASGASGGKGAQGATGAQGATG------AQGATG-ATGASGAQGS
MSMEG_0868|M.smegmatis_MC2_155 TLGGNATGTATAGKGGEASNGGVAGNGGNALVMAAGTTGVATGNTATGGD
MAB_4284c|M.abscessus_ATCC_199 AVGGGAHTGVGGGVSTGVGVGSHVGGGIS---ESLGGSGSVGGSTAVGGG
Mb2377c|M.bovis_AF2122/97 FNSGFANIGSFNAG---------------IANSGNNLAGISNSGDDSSGA
Rv2356c|M.tuberculosis_H37Rv FNSGFANIGSFNAG---------------IANSGNNLAGISNSGDDSSGA
MMAR_3665|M.marinum_M GNSGALDTGYGNAG---------------FYNAAVQNAGFVIAGVNTSGI
MUL_0964|M.ulcerans_Agy99 -NVGFSNSGSNNTG---------------IFNTGTFNTGIANSGSDSSGL
MAV_4704|M.avium_104 --------------------------------------------------
MLBr_01182|M.leprae_Br4923 PARVAVATESESAP---------------LLGGGLPMAPMVPGGGSGTGG
TH_3113|M.thermoresistible__bu PASMSAATAPSAAG---------------IRVLGGAGRISRTRGSVPHAE
Mflv_5091|M.gilvum_PYR-GCK TGAAGAAGAAGSAG-----------TTGAQGSAGTNGA-NGANGSQGAAG
Mvan_1264|M.vanbaalenii_PYR-1 AGSAGSAGVAGSAG-----------TTGAQGSAGTNGA-NGANGSQGAAG
MSMEG_0868|M.smegmatis_MC2_155 GGAATTAGATGGAGGFSNIAAIHGAITDSTAISGHGGAGNGGNGGKGADG
MAB_4284c|M.abscessus_ATCC_199 AHTGVGGGVNTGVG-------------VGSHVGGGISESLGGSGSVGGST
Mb2377c|M.bovis_AF2122/97 VNSGSQNSGAFN---------AGVGLSGFFR-------------------
Rv2356c|M.tuberculosis_H37Rv VNSGSQNSGAFN---------AGVGLSGFFR-------------------
MMAR_3665|M.marinum_M LSSGTGSSGLLV---------FGDGLSGFFKNVL----------------
MUL_0964|M.ulcerans_Agy99 LISGTNSSGALN---------SGDDQSGFNN-------------------
MAV_4704|M.avium_104 --------------------------------------------------
MLBr_01182|M.leprae_Br4923 VNTALRLQPRAF---------VMPRNPAAG--------------------
TH_3113|M.thermoresistible__bu ITPGDPTEPSSP---------TDRAHRPAEPN------------------
Mflv_5091|M.gilvum_PYR-GCK KAGATGTTGATG--------AAGEDGDAGSGGSG-INGGAGGAGG-----
Mvan_1264|M.vanbaalenii_PYR-1 KAGATGTTGATG--------AAGDAGDPGSEAVD-INGGAGGAGG-----
MSMEG_0868|M.smegmatis_MC2_155 WVQAYDPAGPVGSKIANSSAVAGNGGDGGVNGTGGASGGDGGNGGNTSVW
MAB_4284c|M.abscessus_ATCC_199 AVGGGAHTSAIN---------DALGGSGSVGGSTAVGGG-----------
Mb2377c|M.bovis_AF2122/97 --------------------------------------------------
Rv2356c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_3665|M.marinum_M --------------------------------------------------
MUL_0964|M.ulcerans_Agy99 --------------------------------------------------
MAV_4704|M.avium_104 --------------------------------------------------
MLBr_01182|M.leprae_Br4923 --------------------------------------------------
TH_3113|M.thermoresistible__bu --------------------------------------------------
Mflv_5091|M.gilvum_PYR-GCK ------AGGEGGEGGDGGKGGAGAE--------GGAGGGGGAGGSGAGGA
Mvan_1264|M.vanbaalenii_PYR-1 ------AGGEGGEGGAGGAGGDGSE--------GGAGGSGGAGGSGTGGA
MSMEG_0868|M.smegmatis_MC2_155 KSGGQTADGEHNTGGNGGNGGDGSEPGPGGNGAGGAGGNGGTGGTTAGGS
MAB_4284c|M.abscessus_ATCC_199 ------------AHTSAINESMNSSINASHSSSMNESFGSSMGSHGAAGT
Mb2377c|M.bovis_AF2122/97 -----------------------------
Rv2356c|M.tuberculosis_H37Rv -----------------------------
MMAR_3665|M.marinum_M -----------------------------
MUL_0964|M.ulcerans_Agy99 -----------------------------
MAV_4704|M.avium_104 -----------------------------
MLBr_01182|M.leprae_Br4923 -----------------------------
TH_3113|M.thermoresistible__bu -----------------------------
Mflv_5091|M.gilvum_PYR-GCK G--GAGGSGGSGGSGGSGGSGGAAGDSDD
Mvan_1264|M.vanbaalenii_PYR-1 G--GAGGSGGSGGSGGAGGSGGAAGDSD-
MSMEG_0868|M.smegmatis_MC2_155 GNGGNGGNGGNGGADGTPGTAGTTGANNP
MAB_4284c|M.abscessus_ATCC_199 GFEAQGHAQGHASETAHTTLPGAEHH---