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NRTQLLTIFATGLGLFMIFLDAFIVNVALPDIQNTFGVGEDGLQWVVAAYSLGMAVFIMSAATLADRYGR RRWYLMGIALFTLGSIACGLAPSIAMLTAARGIQGFGAATVSVTSLALVSAAFPNPKEKARAIGIWTAVA SVGTATGPTLGGLLVDTWGWRSIFYVNVPMGVFVILLTVGFVAESRNARAGRLDLSGQALFIVTVGAFVY AVIEGPQIGWTSPLILTLLMTAAVGCALFLWLEGRSADPMMDLTLFRDSSYALSIGTICTVFFAVYGMLL LTTQFLQNVRGYTPGATGLMILPFSAGVAVVSPLVGSLVARVGARVLILIGLGLLMLGLLTLIASEHRSW ALVLVGLGFCGTGVALCLTPITTVAMTAVPPERAGMASGIMSAQRAIGSTIGFAVLGSVLAAWLSATLEP HLEPAVPDPVQRHTIAEVIIDSANPRAHVGGIVPRREIVHRDPVAIAEEDFIEGIRVAFFIATASLGFVF LAGWRWFPRGGAGMLGDAEREADAVGL*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_3642 | - | - | 100% (518) | integral membrane transport protein |
| M. marinum M | MMAR_3806 | - | e-117 | 45.24% (504) | integral membrane transport protein |
| M. marinum M | MMAR_1146 | - | 2e-72 | 34.26% (502) | integral membrane transport protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2361c | - | 0.0 | 82.65% (513) | integral membrane transport protein |
| M. gilvum PYR-GCK | Mflv_1730 | - | 3e-80 | 38.19% (419) | EmrB/QacA family drug resistance transporter |
| M. tuberculosis H37Rv | Rv2333c | - | 0.0 | 83.60% (500) | integral membrane transport protein |
| M. leprae Br4923 | MLBr_01562 | - | 2e-47 | 28.99% (407) | putative transmembrane efflux protein |
| M. abscessus ATCC 19977 | MAB_0945 | - | 1e-76 | 36.59% (410) | EmrB/QacA family drug resistance transporter |
| M. avium 104 | MAV_1387 | - | 3e-57 | 32.44% (410) | drug transporter |
| M. smegmatis MC2 155 | MSMEG_5670 | - | 2e-76 | 36.67% (420) | efflux membrane protein |
| M. thermoresistible (build 8) | TH_2682 | - | 4e-64 | 33.64% (538) | PUTATIVE transmembrane efflux protein |
| M. ulcerans Agy99 | MUL_1468 | - | 1e-164 | 97.64% (297) | integral membrane transport protein |
| M. vanbaalenii PYR-1 | Mvan_5021 | - | 1e-79 | 38.05% (410) | EmrB/QacA family drug resistance transporter |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1730|M.gilvum_PYR-GCK -------------------------------------------------M
Mvan_5021|M.vanbaalenii_PYR-1 -------------------------------------------------M
MSMEG_5670|M.smegmatis_MC2_155 ------------------------------------------MNETVGAL
MAB_0945|M.abscessus_ATCC_1997 ------------------------------------------MEAAVGAL
MMAR_3642|M.marinum_M --------------------------------------------------
MUL_1468|M.ulcerans_Agy99 --------------------------------------------------
Mb2361c|M.bovis_AF2122/97 --------------------------------------------------
Rv2333c|M.tuberculosis_H37Rv --------------------------------------------------
TH_2682|M.thermoresistible__bu -------------------------------MVDALSQPGQDIGASVAAL
MAV_1387|M.avium_104 --------------------------------------------------
MLBr_01562|M.leprae_Br4923 MVTLYDHERAVHNWTAARSDRPAPSRLTQQVEPASERTSKYPTLLPSGRF
Mflv_1730|M.gilvum_PYR-GCK TPRRKAIILVSCCLSLLIVSMDATIVNVAIPSIRADLSASPAQMQWVVDI
Mvan_5021|M.vanbaalenii_PYR-1 TPRRKAIILVSCCLSLLIVSMDATIVNVAIPSIRDDLSATPAQMQWVVDV
MSMEG_5670|M.smegmatis_MC2_155 SARRKAIILVSCCLSLLIVSMDATIVNVAIPSIRSDLGASPSQLQWVIDV
MAB_0945|M.abscessus_ATCC_1997 SERRKIVILGSCCLSLLIVSMDSTIVNVALPTIRADFGATTSQLQWVIDI
MMAR_3642|M.marinum_M MNRTQLLTIFATGLGLFMIFLDAFIVNVALPDIQNTFGVGEDGLQWVVAA
MUL_1468|M.ulcerans_Agy99 MNRTQLLTIFATGLGLFMIFLDAFIVNVALPDIQNTFGVGEDGLQWVVAA
Mb2361c|M.bovis_AF2122/97 MNRTQLLTLIATGLGLFMIFLDALIVNVALPDIQRSFAVGEDGLQWVVAS
Rv2333c|M.tuberculosis_H37Rv MNRTQLLTLIATGLGLFMIFLDALIVNVALPDIQRSFAVGEDGLQWVVAS
TH_2682|M.thermoresistible__bu STRARVWLLTVACMGVALVISSMVALNAALPDIAVETAATQSQLTWVVDG
MAV_1387|M.avium_104 -----------MMIGFFMIMVDSTIVAIANPTIMADLHIGYDTVVWVTSA
MLBr_01562|M.leprae_Br4923 PSGRFIAAVIVIGGMQLLATMDSTVAIVALPKIQNELSLSDAGRSWGITA
: . * * * *
Mflv_1730|M.gilvum_PYR-GCK YTLVLASLLMLSGATGDRFGRRRLFQIGLTVFALGSLACSLAPTIDTLIG
Mvan_5021|M.vanbaalenii_PYR-1 YTLVLASLLMLSGATGDRFGRRRVFQIGLAVFALGSLACSLAPTIDALIG
MSMEG_5670|M.smegmatis_MC2_155 YTLVLASLLLLAGATGDRFGRRRTFHLGLTVFAVASLLCSVAPNIETLIA
MAB_0945|M.abscessus_ATCC_1997 YTLGLASLLMLSGAAGDRLGRRKVFHLGLSIFAIGSLLCSVAPTVGLLIA
MMAR_3642|M.marinum_M YSLGMAVFIMSAATLADRYGRRRWYLMGIALFTLGSIACGLAPSIAMLTA
MUL_1468|M.ulcerans_Agy99 YSLGMAVFIMSAATLADRYGRRRWYLMGIVLFTLGSIACGLAPSIAMLTA
Mb2361c|M.bovis_AF2122/97 YSLGMAVFIMSAATLADLYGRRRWYLIGVSLFTLGSIACGLAPSIAVLTT
Rv2333c|M.tuberculosis_H37Rv YSLGMAVFIMSAATLADLDGRRRWYLIGVSLFTLGSIACGLAPSIAVLTT
TH_2682|M.thermoresistible__bu YTLVLACLLLPAGAIGDRYGRRGAMLVGLGLFTVASAAPLVLDGPLTLIL
MAV_1387|M.avium_104 YLLGYAVVLLVAGRLGDRFGTKNLYLIGLAVFTVASVWCGLAGSAAMLIA
MLBr_01562|M.leprae_Br4923 YVLTFGGLMLLGGRLGDTIGRKRTFIVGVALFTISSVLCAVAWDEVTLVI
* * . .:: .. .* * : :*: :*::.* : *
Mflv_1730|M.gilvum_PYR-GCK ARFLQGVGGSMLNPVALSIISQIFTKPVERARALGIWGGVTGISMAAGPI
Mvan_5021|M.vanbaalenii_PYR-1 ARLLQGIGGSMLNPVALSIISQIFTQPVERARALGIWGGVTGISMAAGPI
MSMEG_5670|M.smegmatis_MC2_155 ARLLQAIGGSMLNPVAMSIITQVFTGRVERARAIGVWGSVVGISMALGPL
MAB_0945|M.abscessus_ATCC_1997 ARLLQAVGGSMLNPVALSIISQVFTGRVERARALGFWGAVVGISMALGPI
MMAR_3642|M.marinum_M ARGIQGFGAATVSVTSLALVSAAFPNPKEKARAIGIWTAVASVGTATGPT
MUL_1468|M.ulcerans_Agy99 ARGVQGFGAATVSVTSLALVSAAFPNPKEKARAIGIWTAVASVGTATGPT
Mb2361c|M.bovis_AF2122/97 ARGAQGLGAAAVSVTSLALVSAAFPEAKEKARAIGIWTAIASIGTTTGPT
Rv2333c|M.tuberculosis_H37Rv ARGAQGLGAAAVSVTSLALVSAAFPEAKEKARAIGIWTAIASIGTTTGPT
TH_2682|M.thermoresistible__bu SRMVAGVGAAFVMPATLSLLTAAYPRAQ-RNKAVGIWAAVAGSGAVVGFL
MAV_1387|M.avium_104 ARVVQGVGAGVMTPQTLSTITRIFPAER-RGVAVSVWSATAGAASLAGPL
MLBr_01562|M.leprae_Br4923 ARLLQGIGSAIASPTGLALVATTFSKGSARNTATAVFAAMTAIGSVMGLV
:* ..*.. :: :: :. : * ..: . .. . *
Mflv_1730|M.gilvum_PYR-GCK VGGLLIETVGWRSVFWINLPICAAAIILTAVFVPESKSQTMRNVDPIGQG
Mvan_5021|M.vanbaalenii_PYR-1 VGGLLIDTIGWRSVFWINLPICAAAILLTAIFVPESKSQTMRNVDPIGQG
MSMEG_5670|M.smegmatis_MC2_155 VGGALIEYVDWRAVFWINLPICALAILLTAIFVRESKSSTMRDVDPVGQG
MAB_0945|M.abscessus_ATCC_1997 VGGLLIQWVGWRAVFWINLPVCVLAFVLTAVFVPETKSATMRDIDPVGQA
MMAR_3642|M.marinum_M LGGLLVDTWGWRSIFYVNVPMGVFVILLTVGFVAESRNARAGRLDLSGQA
MUL_1468|M.ulcerans_Agy99 LGGLLVDTWGWRSIFYVNVPMGVFVILLTVGFVAESRNARAGQLDLSGQA
Mb2361c|M.bovis_AF2122/97 LGGLLVDQWGWRSIFYVNLPMGALVLFLTLCYVEESCNERARRFDLSGQL
Rv2333c|M.tuberculosis_H37Rv LGGLLVDQWGWRSIFYVNLPMGALVLFLTLCYVEESCNERARRFDLSGQL
TH_2682|M.thermoresistible__bu GTGVLLHFWSWPSIFWAFTVSGAG-LFVLACTVASSRDHRATPLDWPGAV
MAV_1387|M.avium_104 AGGVLVDGLGWQWIFFVNVPIGVLGLVLAYWLVPVLPTQSHR-FDLVGVG
MLBr_01562|M.leprae_Br4923 VGGALTEVS-WRLAFLVNVPIGLVMIYLARTALHETHKERMK-LDAAGAI
* * . * * : : : .* *
Mflv_1730|M.gilvum_PYR-GCK LGILFLFGTVFTLIEGPVLGWTNPRVLAIAAVAVVALIAFLRFESRRHDP
Mvan_5021|M.vanbaalenii_PYR-1 LAIMFLFGTVFTLIEGPVLGWTNPRVVVAAVVVALALVAFLRFESRRHDP
MSMEG_5670|M.smegmatis_MC2_155 LGVAFLFGVVFVLIEGPGMGWTDPRTLAVAATALVAFLAFLRYESRRHDP
MAB_0945|M.abscessus_ATCC_1997 LAVLFLFGIVFALIEGPSLGWATPGLIVVLAVALAAFAVFLRYESRRRHP
MMAR_3642|M.marinum_M LFIVTVGAFVYAVIEGPQIGWTSPLILTLLMTAAVGCALFLWLEGRSADP
MUL_1468|M.ulcerans_Agy99 LFIVTVGAFVYAVIEGPQIGWTSPLILTLLMTAIVGCALFLWLEGRSADP
Mb2361c|M.bovis_AF2122/97 LFIVAVGALVYAVIEGPQIGWTSVQTIVMLWTAAVGCALFVWLERRSSNP
Rv2333c|M.tuberculosis_H37Rv LFIVAVGALVYAVIEGPQIGWTSVQTIVMLWTAAVGCALFVWLERRSSNP
TH_2682|M.thermoresistible__bu LIGGAVAVFVYGVLEAPVHGWTHPVVYGSMAAGVALALAFAVVELRSAHP
MAV_1387|M.avium_104 LSGVGMLLIVFGLQQGQAAHWQPWIWALIVAGVGFVTVFVFWQSVNVREP
MLBr_01562|M.leprae_Br4923 LATLACTAAVFAFSMGPEKGWISLTTIGSGLVALVAAIAFAVVERTAENP
* *: . . * . . .*
Mflv_1730|M.gilvum_PYR-GCK FLDLRFFRSIPFTTATINAISAFAAWGAFLFMMSLYLQGERGFSAMQTGL
Mvan_5021|M.vanbaalenii_PYR-1 FLDLRFFRSIPFTTATVIAISAFAAWGAFLFLMSLYLQGERGFSAMHTGL
MSMEG_5670|M.smegmatis_MC2_155 FIDLRFFRSVPFASATLVAVCAFAAYGAFLFMMSLYLQSERGYSAMFTGL
MAB_0945|M.abscessus_ATCC_1997 FIDLRFFRSIPFASATLTAICACMAWSAFLFTMSLYLQGQRHFSAMHTGL
MMAR_3642|M.marinum_M MMDLTLFRDSSYALSIGTICTVFFAVYGMLLLTTQFLQNVRGYTPGATGL
MUL_1468|M.ulcerans_Agy99 MMDLTLFRDSSYALSIGTICTVFFAVYGMLLLTTQFLHNVRGYTQGSG--
Mb2361c|M.bovis_AF2122/97 MMDLTLFRDTSYALAIATICTVFFAVYGMLLLTTQFLQNVRGYTPSVTGL
Rv2333c|M.tuberculosis_H37Rv MMDLTLFRDTSYALAIATICTVFFAVYGMLLLTTQFLQNVRGYTPSVTGL
TH_2682|M.thermoresistible__bu LLDIRLFAKPDFTTGAVGVTFFFLANFGFFFVSMQYMQLMLGYSALQTAF
MAV_1387|M.avium_104 LIPLVIFSDRDFSLCNIGVAIISFAATAMMLPLTFYAQAVCGLSPTRSAL
MLBr_01562|M.leprae_Br4923 VVPFDLFRDRNRLVTFIAIFLAGGVIFSLTVSIGLYIQDILGYSALRAGI
.: : :* . . .: . : : :
Mflv_1730|M.gilvum_PYR-GCK IYLPIALGALFCSPLSGRLVGRYGARPSLVAAGILITTAATLLTLLTA-T
Mvan_5021|M.vanbaalenii_PYR-1 IYLPIAIGALLFSPLSGRLVGRYGARPSLVIAGVTITAAATMLTFLTA-T
MSMEG_5670|M.smegmatis_MC2_155 IYLPIAIGALIFSPLSGRMVGRFGSRPSLVSAGVLITAATVMLAQMTA-T
MAB_0945|M.abscessus_ATCC_1997 IYLPIAVGALVFSPISGRMVGRFGARPSLLAAGTLFLTASLLLTRVSE-A
MMAR_3642|M.marinum_M MILPFSAGVAVVSPLVGSLVARVGARVLILIGLGLLMLGLLTLIASEH-R
MUL_1468|M.ulcerans_Agy99 ----------VVD-------------------------------------
Mb2361c|M.bovis_AF2122/97 MILPFSAAVAIVSPLVGHLVGRIGARVPILAGLCMLMLGLLMLIFSEH-R
Rv2333c|M.tuberculosis_H37Rv MILPFSAAVAIVSPLVGHLVGRIGARVPILAGLCMLMLGLLMLIFSEH-R
TH_2682|M.thermoresistible__bu ALTPLTIPLLLLSVTTQWYLPRLGLRAVISTGLLLIAAGLFYARTLEI-A
MAV_1387|M.avium_104 LIAPMAIANGVFAPFVGKIVDRYHPRPVLGFGFSLLAIALTWLTFEMSPA
MLBr_01562|M.leprae_Br4923 GFIPFVIAMGIGLGVSSQLVSRFSPRVLTIGGGWLLMVAMLYGWAFMNRG
.
Mflv_1730|M.gilvum_PYR-GCK TPVWH-LLIVFAVFGVGFSMVNAPITNAAVSGMPLDRAGAASAVTSTSRQ
Mvan_5021|M.vanbaalenii_PYR-1 TPVWS-LLMVFAVFGIGFSMVNAPVTNAAVSGMPLDRAGAASAVTSTSRQ
MSMEG_5670|M.smegmatis_MC2_155 TPVWL-LLVIFAVFGIGFALVNAPITTAAVSGMPLDRAGAASAVASTSRQ
MAB_0945|M.abscessus_ATCC_1997 TPIWE-LLVTFAIFGAGFAMVNAPITNAAVSGMPLDRAGAASAVTSTSRQ
MMAR_3642|M.marinum_M SWALV-LVG-LGFCGTGVALCLTPITTVAMTAVPPERAGMASGIMSAQRA
MUL_1468|M.ulcerans_Agy99 --------------------------------------------------
Mb2361c|M.bovis_AF2122/97 SSALV-LVG-LGLCGSGVALCLTPITTVAMTAVPAERAGMASGIMSAQRA
Rv2333c|M.tuberculosis_H37Rv SSALV-LVG-LGLCGSGVALCLTPITTVAMTAVPAERAGMASGIMSAQRA
TH_2682|M.thermoresistible__bu SPYLD-LAVPLLIMSTGIGLCTAPSTSAIMGAVPDEKHGVASAVNDTTRE
MAV_1387|M.avium_104 TPIWR-LVLPFFAMGVGMAFVWSPLTATATRNLSAQLAGAGSAVYNSVRQ
MLBr_01562|M.leprae_Br4923 VPYFPNLLAPIVVGGIGIGMAVVPLTLSAIAGVGFDRIGPVSAIALMLQS
Mflv_1730|M.gilvum_PYR-GCK VGVSIGVA--------LCGSVAGAAMAGSGTDFATAARPLWFVCIALGLV
Mvan_5021|M.vanbaalenii_PYR-1 VGVSIGVA--------LCGSLAGSAMATGGADFAAAARPLWFVCMALGLV
MSMEG_5670|M.smegmatis_MC2_155 VGVSIGVA--------LCGSVAGTALAGTGVDFAAASRPLWLICTALGVV
MAB_0945|M.abscessus_ATCC_1997 VGVSIGVA--------LCGSIG--------------TPALWFMCAGLGLL
MMAR_3642|M.marinum_M IGSTIGFA--------VLGSVLAAWLSATLEPHLEPAVPDPVQRHTIAEV
MUL_1468|M.ulcerans_Agy99 --------------------------------------------------
Mb2361c|M.bovis_AF2122/97 IGSTIGFA--------VLGSVLAAWLSATLEPHLERAVPDPVQRHVLAEI
Rv2333c|M.tuberculosis_H37Rv IGSTIGFA--------VLGSVLAAWLSATLEPHLERAVPDPVQRHVLAEI
TH_2682|M.thermoresistible__bu IGAALGIA--------VAGSVLAAEYGDRLRPHLG-ALPEPVR--QAASN
MAV_1387|M.avium_104 LGAVLGSAGMAAFMTWRIGAEMPGQPGGGGEDSAGPVLPEFLRGPFAAAM
MLBr_01562|M.leprae_Br4923 LGGPLVLAVIQ---AVITSRTLYLGGTTGPVKFMNDAQLRALDHGYTYGL
Mflv_1730|M.gilvum_PYR-GCK ILAVG---------------------------------------------
Mvan_5021|M.vanbaalenii_PYR-1 ILGLG---------------------------------------------
MSMEG_5670|M.smegmatis_MC2_155 IVAIG---------------------------------------------
MAB_0945|M.abscessus_ATCC_1997 IATLG---------------------------------------------
MMAR_3642|M.marinum_M IIDSANPRAHVGG-------------------------------------
MUL_1468|M.ulcerans_Agy99 --------------------------------------------------
Mb2361c|M.bovis_AF2122/97 IIDSANPRAHVGG-------------------------------------
Rv2333c|M.tuberculosis_H37Rv IIDSANPRAHVGG-------------------------------------
TH_2682|M.thermoresistible__bu SLAEALEAARQLG-------------------------------------
MAV_1387|M.avium_104 SQSVLLPAFIALFGIVAALFLVGFRPWAHRDGGTDAFGPDDYGGDYHDDY
MLBr_01562|M.leprae_Br4923 LWVAG---------------------------------------------
Mflv_1730|M.gilvum_PYR-GCK --------FFSTSQRAVRSAERLAPLVAGAPDPVNGAHVR----------
Mvan_5021|M.vanbaalenii_PYR-1 --------LFATSQRALRSAERLAPLVSGAPEPVGGAHVR----------
MSMEG_5670|M.smegmatis_MC2_155 --------IVSTSPWALRSAERLAPLIGQHHRPAEVAHAR----------
MAB_0945|M.abscessus_ATCC_1997 --------IVSTSPAAVRSAQRLAPLIEGT-TAREMSRVG----------
MMAR_3642|M.marinum_M ---IVPRREIVHRDPVAIAEEDFIEGIRVAFFIATASLGFVFLAGWR---
MUL_1468|M.ulcerans_Agy99 --------------------------------------------------
Mb2361c|M.bovis_AF2122/97 ---IVPRRHIEHRDPVAIAEEDFIEGIRVALLVATATLAVVFLAGWR---
Rv2333c|M.tuberculosis_H37Rv ---IVPRRHIEHRDPVAIAEEDFIEGIRVALLVATATLAVVFLAGWR---
TH_2682|M.thermoresistible__bu ---PQGARLAEFAQSAFLEAMHVSLIVLGALCALAAAFVAVWAPGRDGRQ
MAV_1387|M.avium_104 DDDDAYVELILVREPEPEAQQRAGQPRRPQPTPAPPADVRRRDPVESRRS
MLBr_01562|M.leprae_Br4923 --------AVVIVGVAALFIGYTPEQVAYAQEVKEAVDAGEL--------
Mflv_1730|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5021|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_5670|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0945|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_3642|M.marinum_M -WFPRGGAGMLGDAEREADAVGL---------------------------
MUL_1468|M.ulcerans_Agy99 --------------------------------------------------
Mb2361c|M.bovis_AF2122/97 -WFPRDVQTAGSDAKR--EAAYSDDRRVRG--------------------
Rv2333c|M.tuberculosis_H37Rv -WFPRDVHTAGSDLSERLPTAMTVECAVSHMPGATWCRLWPA--------
TH_2682|M.thermoresistible__bu YGFVERWTSRWSGEEAGGAVAEHDDGGVRAATGDGWEHGTVDDP------
MAV_1387|M.avium_104 VLDERPAQVQPIGFAHNGSHVDGGKRLRQVAVRRAPKPGPPADRFTRPPR
MLBr_01562|M.leprae_Br4923 --------------------------------------------------
Mflv_1730|M.gilvum_PYR-GCK ----------------------------------------
Mvan_5021|M.vanbaalenii_PYR-1 ----------------------------------------
MSMEG_5670|M.smegmatis_MC2_155 ----------------------------------------
MAB_0945|M.abscessus_ATCC_1997 ----------------------------------------
MMAR_3642|M.marinum_M ----------------------------------------
MUL_1468|M.ulcerans_Agy99 ----------------------------------------
Mb2361c|M.bovis_AF2122/97 ----------------------------------------
Rv2333c|M.tuberculosis_H37Rv ----------------------------------------
TH_2682|M.thermoresistible__bu ----------------------------------------
MAV_1387|M.avium_104 RHHPGPAGHHLGEGESLRGQHHRPDPDDDPTGYGRHSSGN
MLBr_01562|M.leprae_Br4923 ----------------------------------------