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MNRTQLLTIFATGLGLFMIFLDAFIVNVALPDIQNTFGVGEDGLQWVVAAYSLGMAVFIMSAATLADRYG RRRWYLMGIVLFTLGSIACGLAPSIAMLTAARGVQGFGAATVSVTSLALVSAAFPNPKEKARAIGIWTAV ASVGTATGPTLGGLLVDTWGWRSIFYVNVPMGVFVILLTVGFVAESRNARAGQLDLSGQALFIVTVGAFV YAVIEGPQIGWTSPLILTLLMTAIVGCALFLWLEGRSADPMMDLTLFRDSSYALSIGTICTVFFAVYGML LLTTQFLHNVRGYTQGSGVVD
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_1468 | - | - | 100% (301) | integral membrane transport protein |
| M. ulcerans Agy99 | MUL_3729 | - | 2e-71 | 47.60% (292) | integral membrane transport protein |
| M. ulcerans Agy99 | MUL_0911 | - | 6e-54 | 38.62% (290) | integral membrane transport protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2361c | - | 1e-136 | 81.29% (294) | integral membrane transport protein |
| M. gilvum PYR-GCK | Mflv_1730 | - | 1e-58 | 37.67% (292) | EmrB/QacA family drug resistance transporter |
| M. tuberculosis H37Rv | Rv2333c | - | 1e-135 | 80.95% (294) | integral membrane transport protein |
| M. leprae Br4923 | MLBr_01562 | - | 9e-36 | 29.93% (274) | putative transmembrane efflux protein |
| M. abscessus ATCC 19977 | MAB_0945 | - | 9e-56 | 35.62% (292) | EmrB/QacA family drug resistance transporter |
| M. marinum M | MMAR_3642 | - | 1e-164 | 97.64% (297) | integral membrane transport protein |
| M. avium 104 | MAV_1387 | - | 9e-43 | 34.64% (280) | drug transporter |
| M. smegmatis MC2 155 | MSMEG_5670 | - | 3e-55 | 36.18% (293) | efflux membrane protein |
| M. thermoresistible (build 8) | TH_2858 | - | 5e-42 | 32.76% (293) | PUTATIVE major facilitator superfamily MFS_1 |
| M. vanbaalenii PYR-1 | Mvan_5021 | - | 4e-58 | 37.67% (292) | EmrB/QacA family drug resistance transporter |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_1468|M.ulcerans_Agy99 --------------------------------------------------
MMAR_3642|M.marinum_M --------------------------------------------------
Mb2361c|M.bovis_AF2122/97 --------------------------------------------------
Rv2333c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_1730|M.gilvum_PYR-GCK -------------------------------------------------M
Mvan_5021|M.vanbaalenii_PYR-1 -------------------------------------------------M
MSMEG_5670|M.smegmatis_MC2_155 ------------------------------------------MNETVGAL
MAB_0945|M.abscessus_ATCC_1997 ------------------------------------------MEAAVGAL
MLBr_01562|M.leprae_Br4923 MVTLYDHERAVHNWTAARSDRPAPSRLTQQVEPASERTSKYPTLLPSGRF
TH_2858|M.thermoresistible__bu ----------------------------------MEGANKLPTWLPSR--
MAV_1387|M.avium_104 --------------------------------------------------
MUL_1468|M.ulcerans_Agy99 MNRTQLLTIFATGLGLFMIFLDAFIVNVALPDIQNTFGVGEDGLQWVVAA
MMAR_3642|M.marinum_M MNRTQLLTIFATGLGLFMIFLDAFIVNVALPDIQNTFGVGEDGLQWVVAA
Mb2361c|M.bovis_AF2122/97 MNRTQLLTLIATGLGLFMIFLDALIVNVALPDIQRSFAVGEDGLQWVVAS
Rv2333c|M.tuberculosis_H37Rv MNRTQLLTLIATGLGLFMIFLDALIVNVALPDIQRSFAVGEDGLQWVVAS
Mflv_1730|M.gilvum_PYR-GCK TPRRKAIILVSCCLSLLIVSMDATIVNVAIPSIRADLSASPAQMQWVVDI
Mvan_5021|M.vanbaalenii_PYR-1 TPRRKAIILVSCCLSLLIVSMDATIVNVAIPSIRDDLSATPAQMQWVVDV
MSMEG_5670|M.smegmatis_MC2_155 SARRKAIILVSCCLSLLIVSMDATIVNVAIPSIRSDLGASPSQLQWVIDV
MAB_0945|M.abscessus_ATCC_1997 SERRKIVILGSCCLSLLIVSMDSTIVNVALPTIRADFGATTSQLQWVIDI
MLBr_01562|M.leprae_Br4923 PSGRFIAAVIVIGGMQLLATMDSTVAIVALPKIQNELSLSDAGRSWGITA
TH_2858|M.thermoresistible__bu ---RFIAAVFAIGGMQLLATMDSTIAIVALPRIQDELNLTDAGRSWVITA
MAV_1387|M.avium_104 -----------MMIGFFMIMVDSTIVAIANPTIMADLHIGYDTVVWVTSA
:: :*: :. :* * * : *
MUL_1468|M.ulcerans_Agy99 YSLGMAVFIMSAATLADRYGRRRWYLMGIVLFTLGSIACGLAPSIAMLTA
MMAR_3642|M.marinum_M YSLGMAVFIMSAATLADRYGRRRWYLMGIALFTLGSIACGLAPSIAMLTA
Mb2361c|M.bovis_AF2122/97 YSLGMAVFIMSAATLADLYGRRRWYLIGVSLFTLGSIACGLAPSIAVLTT
Rv2333c|M.tuberculosis_H37Rv YSLGMAVFIMSAATLADLDGRRRWYLIGVSLFTLGSIACGLAPSIAVLTT
Mflv_1730|M.gilvum_PYR-GCK YTLVLASLLMLSGATGDRFGRRRLFQIGLTVFALGSLACSLAPTIDTLIG
Mvan_5021|M.vanbaalenii_PYR-1 YTLVLASLLMLSGATGDRFGRRRVFQIGLAVFALGSLACSLAPTIDALIG
MSMEG_5670|M.smegmatis_MC2_155 YTLVLASLLLLAGATGDRFGRRRTFHLGLTVFAVASLLCSVAPNIETLIA
MAB_0945|M.abscessus_ATCC_1997 YTLGLASLLMLSGAAGDRLGRRKVFHLGLSIFAIGSLLCSVAPTVGLLIA
MLBr_01562|M.leprae_Br4923 YVLTFGGLMLLGGRLGDTIGRKRTFIVGVALFTISSVLCAVAWDEVTLVI
TH_2858|M.thermoresistible__bu YVLTFGGLMLLGGRLGDTIGRKRTFIVGVTLFTIASVLCGIAWDEATLVI
MAV_1387|M.avium_104 YLLGYAVVLLVAGRLGDRFGTKNLYLIGLAVFTVASVWCGLAGSAAMLIA
* * . .:: .. .* * :. : :*: :*::.*: *.:* *
MUL_1468|M.ulcerans_Agy99 ARGVQGFGAATVSVTSLALVSAAFPNPKEKARAIGIWTAVASVGTATGPT
MMAR_3642|M.marinum_M ARGIQGFGAATVSVTSLALVSAAFPNPKEKARAIGIWTAVASVGTATGPT
Mb2361c|M.bovis_AF2122/97 ARGAQGLGAAAVSVTSLALVSAAFPEAKEKARAIGIWTAIASIGTTTGPT
Rv2333c|M.tuberculosis_H37Rv ARGAQGLGAAAVSVTSLALVSAAFPEAKEKARAIGIWTAIASIGTTTGPT
Mflv_1730|M.gilvum_PYR-GCK ARFLQGVGGSMLNPVALSIISQIFTKPVERARALGIWGGVTGISMAAGPI
Mvan_5021|M.vanbaalenii_PYR-1 ARLLQGIGGSMLNPVALSIISQIFTQPVERARALGIWGGVTGISMAAGPI
MSMEG_5670|M.smegmatis_MC2_155 ARLLQAIGGSMLNPVAMSIITQVFTGRVERARAIGVWGSVVGISMALGPL
MAB_0945|M.abscessus_ATCC_1997 ARLLQAVGGSMLNPVALSIISQVFTGRVERARALGFWGAVVGISMALGPI
MLBr_01562|M.leprae_Br4923 ARLLQGIGSAIASPTGLALVATTFSKGSARNTATAVFAAMTAIGSVMGLV
TH_2858|M.thermoresistible__bu ARLLQGVGAAIASPTGLALVATTFPKGPARNAATAVFAAMTGVGSVMGLV
MAV_1387|M.avium_104 ARVVQGVGAGVMTPQTLSTITRIFP-AERRGVAVSVWSATAGAASLAGPL
** *..*.. . :: :: *. : * ..: . .. . *
MUL_1468|M.ulcerans_Agy99 LGGLLVDTWGWRSIFYVNVPMGVFVILLTVGFVAESRNARAGQLDLSGQA
MMAR_3642|M.marinum_M LGGLLVDTWGWRSIFYVNVPMGVFVILLTVGFVAESRNARAGRLDLSGQA
Mb2361c|M.bovis_AF2122/97 LGGLLVDQWGWRSIFYVNLPMGALVLFLTLCYVEESCNERARRFDLSGQL
Rv2333c|M.tuberculosis_H37Rv LGGLLVDQWGWRSIFYVNLPMGALVLFLTLCYVEESCNERARRFDLSGQL
Mflv_1730|M.gilvum_PYR-GCK VGGLLIETVGWRSVFWINLPICAAAIILTAVFVPESKSQTMRNVDPIGQG
Mvan_5021|M.vanbaalenii_PYR-1 VGGLLIDTIGWRSVFWINLPICAAAILLTAIFVPESKSQTMRNVDPIGQG
MSMEG_5670|M.smegmatis_MC2_155 VGGALIEYVDWRAVFWINLPICALAILLTAIFVRESKSSTMRDVDPVGQG
MAB_0945|M.abscessus_ATCC_1997 VGGLLIQWVGWRAVFWINLPVCVLAFVLTAVFVPETKSATMRDIDPVGQA
MLBr_01562|M.leprae_Br4923 VGGALTEVS-WRLAFLVNVPIGLVMIYLARTALHETHKERMK-LDAAGAI
TH_2858|M.thermoresistible__bu VGGALTEVS-WRLAFLVNVPIGLLVIYLARRTLRETHRERLK-LDAAGAI
MAV_1387|M.avium_104 AGGVLVDGLGWQWIFFVNVPIGVLGLVLAYWLVPVLPTQSHR-FDLVGVG
** * : *: * :*:*: : *: : .* *
MUL_1468|M.ulcerans_Agy99 LFIVTVGAFVYAVIEGPQIGWTSPLILTLLMTAIVGCALFLWLEGRSADP
MMAR_3642|M.marinum_M LFIVTVGAFVYAVIEGPQIGWTSPLILTLLMTAAVGCALFLWLEGRSADP
Mb2361c|M.bovis_AF2122/97 LFIVAVGALVYAVIEGPQIGWTSVQTIVMLWTAAVGCALFVWLERRSSNP
Rv2333c|M.tuberculosis_H37Rv LFIVAVGALVYAVIEGPQIGWTSVQTIVMLWTAAVGCALFVWLERRSSNP
Mflv_1730|M.gilvum_PYR-GCK LGILFLFGTVFTLIEGPVLGWTNPRVLAIAAVAVVALIAFLRFESRRHDP
Mvan_5021|M.vanbaalenii_PYR-1 LAIMFLFGTVFTLIEGPVLGWTNPRVVVAAVVVALALVAFLRFESRRHDP
MSMEG_5670|M.smegmatis_MC2_155 LGVAFLFGVVFVLIEGPGMGWTDPRTLAVAATALVAFLAFLRYESRRHDP
MAB_0945|M.abscessus_ATCC_1997 LAVLFLFGIVFALIEGPSLGWATPGLIVVLAVALAAFAVFLRYESRRRHP
MLBr_01562|M.leprae_Br4923 LATLACTAAVFAFSMGPEKGWISLTTIGSGLVALVAAIAFAVVERTAENP
TH_2858|M.thermoresistible__bu LATLGCTAAVFAFSMGPERGWASVITIATGAAALVFLLAFLYVERTADNP
MAV_1387|M.avium_104 LSGVGMLLIVFGLQQGQAAHWQPWIWALIVAGVGFVTVFVFWQSVNVREP
* *: . * * . . . .*
MUL_1468|M.ulcerans_Agy99 MMDLTLFRDSSYALSIGTICTVFFAVYGMLLLTTQFLHNVRGYTQGSG--
MMAR_3642|M.marinum_M MMDLTLFRDSSYALSIGTICTVFFAVYGMLLLTTQFLQNVRGYTPGATGL
Mb2361c|M.bovis_AF2122/97 MMDLTLFRDTSYALAIATICTVFFAVYGMLLLTTQFLQNVRGYTPSVTGL
Rv2333c|M.tuberculosis_H37Rv MMDLTLFRDTSYALAIATICTVFFAVYGMLLLTTQFLQNVRGYTPSVTGL
Mflv_1730|M.gilvum_PYR-GCK FLDLRFFRSIPFTTATINAISAFAAWGAFLFMMSLYLQGERGFSAMQTGL
Mvan_5021|M.vanbaalenii_PYR-1 FLDLRFFRSIPFTTATVIAISAFAAWGAFLFLMSLYLQGERGFSAMHTGL
MSMEG_5670|M.smegmatis_MC2_155 FIDLRFFRSVPFASATLVAVCAFAAYGAFLFMMSLYLQSERGYSAMFTGL
MAB_0945|M.abscessus_ATCC_1997 FIDLRFFRSIPFASATLTAICACMAWSAFLFTMSLYLQGQRHFSAMHTGL
MLBr_01562|M.leprae_Br4923 VVPFDLFRDRNRLVTFIAIFLAGGVIFSLTVSIGLYIQDILGYSALRAGI
TH_2858|M.thermoresistible__bu VVPFSLFRDRNRVATFGAIFLAGGVMFTLTVLIGLYVQDIMGYSPLRAGI
MAV_1387|M.avium_104 LIPLVIFSDRDFSLCNIGVAIISFAATAMMLPLTFYAQAVCGLSPTRSAL
.: : :* . . : . : : :
MUL_1468|M.ulcerans_Agy99 ----------VVD-------------------------------------
MMAR_3642|M.marinum_M MILPFSAGVAVVSPLVGSLVARVGAR-VLILIGLGLLMLGLLTLIASEHR
Mb2361c|M.bovis_AF2122/97 MILPFSAAVAIVSPLVGHLVGRIGAR-VPILAGLCMLMLGLLMLIFSEHR
Rv2333c|M.tuberculosis_H37Rv MILPFSAAVAIVSPLVGHLVGRIGAR-VPILAGLCMLMLGLLMLIFSEHR
Mflv_1730|M.gilvum_PYR-GCK IYLPIALGALFCSPLSGRLVGRYGARPSLVAAGILITTAATLLTLLTATT
Mvan_5021|M.vanbaalenii_PYR-1 IYLPIAIGALLFSPLSGRLVGRYGARPSLVIAGVTITAAATMLTFLTATT
MSMEG_5670|M.smegmatis_MC2_155 IYLPIAIGALIFSPLSGRMVGRFGSRPSLVSAGVLITAATVMLAQMTATT
MAB_0945|M.abscessus_ATCC_1997 IYLPIAVGALVFSPISGRMVGRFGARPSLLAAGTLFLTASLLLTRVSEAT
MLBr_01562|M.leprae_Br4923 GFIPFVIAMGIGLGVSSQLVSRFSPRVLTIGGGWLLMVAMLYGWAFMNRG
TH_2858|M.thermoresistible__bu GFIPFVIALGIGLAASSQLVRLFPPRVLVFGGGVLVLGAMLYG-STLHAD
MAV_1387|M.avium_104 LIAPMAIANGVFAPFVGKIVDRYHPR-PVLGFGFSLLAIALTWLTFEMSP
.
MUL_1468|M.ulcerans_Agy99 --------------------------------------------------
MMAR_3642|M.marinum_M S--WALVLVGLGFCGTGVALCLTPITTVAMTAVPPERAGMASGIMSAQRA
Mb2361c|M.bovis_AF2122/97 S--SALVLVGLGLCGSGVALCLTPITTVAMTAVPAERAGMASGIMSAQRA
Rv2333c|M.tuberculosis_H37Rv S--SALVLVGLGLCGSGVALCLTPITTVAMTAVPAERAGMASGIMSAQRA
Mflv_1730|M.gilvum_PYR-GCK P--VWHLLIVFAVFGVGFSMVNAPITNAAVSGMPLDRAGAASAVTSTSRQ
Mvan_5021|M.vanbaalenii_PYR-1 P--VWSLLMVFAVFGIGFSMVNAPVTNAAVSGMPLDRAGAASAVTSTSRQ
MSMEG_5670|M.smegmatis_MC2_155 P--VWLLLVIFAVFGIGFALVNAPITTAAVSGMPLDRAGAASAVASTSRQ
MAB_0945|M.abscessus_ATCC_1997 P--IWELLVTFAIFGAGFAMVNAPITNAAVSGMPLDRAGAASAVTSTSRQ
MLBr_01562|M.leprae_Br4923 VPYFPNLLAPIVVGGIGIGMAVVPLTLSAIAGVGFDRIGPVSAIALMLQS
TH_2858|M.thermoresistible__bu IPYFPNLVVPIVVGGIGIGVIVVPLTVSAIAGVGFDQIGPVSAIALMLQN
MAV_1387|M.avium_104 ATPIWRLVLPFFAMGVGMAFVWSPLTATATRNLSAQLAGAGSAVYNSVRQ
MUL_1468|M.ulcerans_Agy99 --------------------------------------------------
MMAR_3642|M.marinum_M IGSTIGFAVLGSVLAAWL-------SATLEPHLEPAVPDPVQRHTIAE--
Mb2361c|M.bovis_AF2122/97 IGSTIGFAVLGSVLAAWL-------SATLEPHLERAVPDPVQRHVLAE--
Rv2333c|M.tuberculosis_H37Rv IGSTIGFAVLGSVLAAWL-------SATLEPHLERAVPDPVQRHVLAE--
Mflv_1730|M.gilvum_PYR-GCK VGVSIGVALCGSVAGAAM-------AGSGTDFATAARPLWFVCIALGL--
Mvan_5021|M.vanbaalenii_PYR-1 VGVSIGVALCGSLAGSAM-------ATGGADFAAAARPLWFVCMALGL--
MSMEG_5670|M.smegmatis_MC2_155 VGVSIGVALCGSVAGTAL-------AGTGVDFAAASRPLWLICTALGV--
MAB_0945|M.abscessus_ATCC_1997 VGVSIGVALCGSIG---------------------TPALWFMCAGLGL--
MLBr_01562|M.leprae_Br4923 LGGPLVLAVIQAVITSRT-------LYLGGTTGPVKFMNDAQLRALDHGY
TH_2858|M.thermoresistible__bu LGGPLVLAVVQAVITSRT-------LYLGGTTGPVQNMDTAQLHALDQGY
MAV_1387|M.avium_104 LGAVLGSAGMAAFMTWRIGAEMPGQPGGGGEDSAGPVLPEFLRGPFAAAM
MUL_1468|M.ulcerans_Agy99 --------------------------------------------------
MMAR_3642|M.marinum_M ---VIIDSANPRAHVGGIVPRR----------------------------
Mb2361c|M.bovis_AF2122/97 ---IIIDSANPRAHVGGIVPRR----------------------------
Rv2333c|M.tuberculosis_H37Rv ---IIIDSANPRAHVGGIVPRR----------------------------
Mflv_1730|M.gilvum_PYR-GCK ---VILAVG---FFSTSQRAVR----------------------------
Mvan_5021|M.vanbaalenii_PYR-1 ---VILGLG---LFATSQRALR----------------------------
MSMEG_5670|M.smegmatis_MC2_155 ---VIVAIG---IVSTSPWALR----------------------------
MAB_0945|M.abscessus_ATCC_1997 ---LIATLG---IVSTSPAAVR----------------------------
MLBr_01562|M.leprae_Br4923 TYGLLWVAGAVVIVGVAALFIG----------------------------
TH_2858|M.thermoresistible__bu TYGLLWVAAVAVLVGGAALFIG----------------------------
MAV_1387|M.avium_104 SQSVLLPAFIALFGIVAALFLVGFRPWAHRDGGTDAFGPDDYGGDYHDDY
MUL_1468|M.ulcerans_Agy99 --------------------------------------------------
MMAR_3642|M.marinum_M -----------------------------EIVHRDPVAIAEEDFIEGIRV
Mb2361c|M.bovis_AF2122/97 -----------------------------HIEHRDPVAIAEEDFIEGIRV
Rv2333c|M.tuberculosis_H37Rv -----------------------------HIEHRDPVAIAEEDFIEGIRV
Mflv_1730|M.gilvum_PYR-GCK -----------------------------SAERLAPLVAGAPDPVNGAHV
Mvan_5021|M.vanbaalenii_PYR-1 -----------------------------SAERLAPLVSGAPEPVGGAHV
MSMEG_5670|M.smegmatis_MC2_155 -----------------------------SAERLAPLIGQHHRPAEVAHA
MAB_0945|M.abscessus_ATCC_1997 -----------------------------SAQRLAPLIEGT-TAREMSRV
MLBr_01562|M.leprae_Br4923 -----------------------------YTPEQVAYAQEVKEAVDAGEL
TH_2858|M.thermoresistible__bu -----------------------------YTAKQVAHAQEVKDAIDAGEL
MAV_1387|M.avium_104 DDDDAYVELILVREPEPEAQQRAGQPRRPQPTPAPPADVRRRDPVESRRS
MUL_1468|M.ulcerans_Agy99 --------------------------------------------------
MMAR_3642|M.marinum_M AFFIATASLGFVFLAGWRWFPRGGAGMLGDAEREADAVGL----------
Mb2361c|M.bovis_AF2122/97 ALLVATATLAVVFLAGWRWFPRDVQTAGSDAKR--EAAYSDDRRVRG---
Rv2333c|M.tuberculosis_H37Rv ALLVATATLAVVFLAGWRWFPRDVHTAGSDLSERLPTAMTVECAVSHMPG
Mflv_1730|M.gilvum_PYR-GCK R-------------------------------------------------
Mvan_5021|M.vanbaalenii_PYR-1 R-------------------------------------------------
MSMEG_5670|M.smegmatis_MC2_155 R-------------------------------------------------
MAB_0945|M.abscessus_ATCC_1997 G-------------------------------------------------
MLBr_01562|M.leprae_Br4923 --------------------------------------------------
TH_2858|M.thermoresistible__bu --------------------------------------------------
MAV_1387|M.avium_104 VLDERPAQVQPIGFAHNGSHVDGGKRLRQVAVRRAPKPGPPADRFTRPPR
MUL_1468|M.ulcerans_Agy99 ----------------------------------------
MMAR_3642|M.marinum_M ----------------------------------------
Mb2361c|M.bovis_AF2122/97 ----------------------------------------
Rv2333c|M.tuberculosis_H37Rv ATWCRLWPA-------------------------------
Mflv_1730|M.gilvum_PYR-GCK ----------------------------------------
Mvan_5021|M.vanbaalenii_PYR-1 ----------------------------------------
MSMEG_5670|M.smegmatis_MC2_155 ----------------------------------------
MAB_0945|M.abscessus_ATCC_1997 ----------------------------------------
MLBr_01562|M.leprae_Br4923 ----------------------------------------
TH_2858|M.thermoresistible__bu ----------------------------------------
MAV_1387|M.avium_104 RHHPGPAGHHLGEGESLRGQHHRPDPDDDPTGYGRHSSGN