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MTRRQRLTVAATGLGIFMVFVDVNIVNVALPSIQRVFHTGEQGLQWAVAGYSLGMAAMLMSCALLGDRYG RRRGFFVGLALFVASSVVCVLPINLGMFTAARVIQGLGASFISVLSLALLSHAFPDQRMKARAIADWMAI GMVGAASAPALGGLMVETLGWRSVFAVNVPLGAIVLVLTLIGVDESRDPDPTELDWVGQLTFVPGIAVLA YTIIEAPRFQQRSVIVLTSLLLIIVALLWTFIRHERRAPFPLIDLQLFTEPVYRSVLIVYFVVMSCFFGT LMVITQFFQNVRDLSPLHAGLMMLPVPAGFGMASLLAGAAVNKWGPRLPVVTCLAAMVTGLVLFVTAMGH VPALALMGLTVFGAGAGGSVTPLLHLGMTKVDDHRAGMAAGLLNLQRSMGGIFGVAFLGSILAAWLGATL PDSMEDDLPDPVVRSIVVDTIVDSANPHAHAAFIGPRHRITSAQETNIVSAADSDFMQGIRIALGCASVL LAAAFVLGLRRFPRPDSDESPDPDESQLAGSDLD
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_3806 | - | - | 100% (524) | integral membrane transport protein |
| M. marinum M | MMAR_3642 | - | e-117 | 45.24% (504) | integral membrane transport protein |
| M. marinum M | MMAR_1146 | - | 6e-60 | 30.54% (501) | integral membrane transport protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2486 | - | 0.0 | 77.78% (504) | integral membrane transport protein |
| M. gilvum PYR-GCK | Mflv_1730 | - | 7e-56 | 30.40% (421) | EmrB/QacA family drug resistance transporter |
| M. tuberculosis H37Rv | Rv2459 | - | 0.0 | 77.98% (504) | integral membrane transport protein |
| M. leprae Br4923 | MLBr_01562 | - | 5e-37 | 26.35% (406) | putative transmembrane efflux protein |
| M. abscessus ATCC 19977 | MAB_0945 | - | 2e-56 | 30.00% (410) | EmrB/QacA family drug resistance transporter |
| M. avium 104 | MAV_0729 | - | 1e-46 | 28.71% (411) | EmrB efflux protein |
| M. smegmatis MC2 155 | MSMEG_5670 | - | 9e-55 | 29.90% (418) | efflux membrane protein |
| M. thermoresistible (build 8) | TH_2682 | - | 2e-43 | 30.04% (496) | PUTATIVE transmembrane efflux protein |
| M. ulcerans Agy99 | MUL_3729 | - | 0.0 | 98.85% (524) | integral membrane transport protein |
| M. vanbaalenii PYR-1 | Mvan_5021 | - | 1e-57 | 31.14% (411) | EmrB/QacA family drug resistance transporter |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1730|M.gilvum_PYR-GCK -------------------------------------------------M
Mvan_5021|M.vanbaalenii_PYR-1 -------------------------------------------------M
MSMEG_5670|M.smegmatis_MC2_155 ------------------------------------------MNETVGAL
MAB_0945|M.abscessus_ATCC_1997 ------------------------------------------MEAAVGAL
MMAR_3806|M.marinum_M --------------------------------------------------
MUL_3729|M.ulcerans_Agy99 --------------------MSNPGEIGEPPTTSGSAEVPATAPATDNVV
Mb2486|M.bovis_AF2122/97 --------------------------------------------------
Rv2459|M.tuberculosis_H37Rv --------------------------------------------------
TH_2682|M.thermoresistible__bu -------------------------------MVDALSQPGQDIGASVAAL
MLBr_01562|M.leprae_Br4923 MVTLYDHERAVHNWTAARSDRPAPSRLTQQVEPASERTSKYPTLLPSGRF
MAV_0729|M.avium_104 ----------------MLSGAMEKTRSAAFSVPLATASGPSLRDDEYPDK
Mflv_1730|M.gilvum_PYR-GCK TPRRKAIILVSCCLSLLIVSMDATIVNVAIPSIRADLSASPAQMQWVVDI
Mvan_5021|M.vanbaalenii_PYR-1 TPRRKAIILVSCCLSLLIVSMDATIVNVAIPSIRDDLSATPAQMQWVVDV
MSMEG_5670|M.smegmatis_MC2_155 SARRKAIILVSCCLSLLIVSMDATIVNVAIPSIRSDLGASPSQLQWVIDV
MAB_0945|M.abscessus_ATCC_1997 SERRKIVILGSCCLSLLIVSMDSTIVNVALPTIRADFGATTSQLQWVIDI
MMAR_3806|M.marinum_M MTRRQRLTVAATGLGIFMVFVDVNIVNVALPSIQRVFHTGEQGLQWAVAG
MUL_3729|M.ulcerans_Agy99 MTRRQRLTVAATGLGIFMVFVDVNIVNVALPSIQRVFHTGEQGLQWAVAG
Mb2486|M.bovis_AF2122/97 MTPRQRLTVLATGLGIFMVFVDVNIVNVALPSIQKVFHTGEQGLQWAVAG
Rv2459|M.tuberculosis_H37Rv MTPRQRLTVLATGLGIFMVFVDVNIVNVALPSIQKVFHTGEQGLQWAVAG
TH_2682|M.thermoresistible__bu STRARVWLLTVACMGVALVISSMVALNAALPDIAVETAATQSQLTWVVDG
MLBr_01562|M.leprae_Br4923 PSGRFIAAVIVIGGMQLLATMDSTVAIVALPKIQNELSLSDAGRSWGITA
MAV_0729|M.avium_104 LDAALFRIAGVCGLACIMAVLDSTVVAVAQRTFIAQFGANQAIVSWTIAG
:. . .* : * :
Mflv_1730|M.gilvum_PYR-GCK YTLVLASLLMLSGATGDRFGRRRLFQIGLTVFALGSLACSLAPTIDTLIG
Mvan_5021|M.vanbaalenii_PYR-1 YTLVLASLLMLSGATGDRFGRRRVFQIGLAVFALGSLACSLAPTIDALIG
MSMEG_5670|M.smegmatis_MC2_155 YTLVLASLLLLAGATGDRFGRRRTFHLGLTVFAVASLLCSVAPNIETLIA
MAB_0945|M.abscessus_ATCC_1997 YTLGLASLLMLSGAAGDRLGRRKVFHLGLSIFAIGSLLCSVAPTVGLLIA
MMAR_3806|M.marinum_M YSLGMAAMLMSCALLGDRYGRRRGFFVGLALFVASSVVCVLPINLGMFTA
MUL_3729|M.ulcerans_Agy99 YSLGMAAMLMSCALLGDRYGRRRGFFVGLALFVASSVVCVLPINLGMFTA
Mb2486|M.bovis_AF2122/97 YSLGIAAVLMSCALLGDRYGRRRSFVFGVTLFVVSSIVCVLPVSLAVFTV
Rv2459|M.tuberculosis_H37Rv YSLGMAAVLMSCALLGDRYGRRRSFVFGVTLFVVSSIVCVLPVSLAVFTV
TH_2682|M.thermoresistible__bu YTLVLACLLLPAGAIGDRYGRRGAMLVGLGLFTVASAAPLVLDGPLTLIL
MLBr_01562|M.leprae_Br4923 YVLTFGGLMLLGGRLGDTIGRKRTFIVGVALFTISSVLCAVAWDEVTLVI
MAV_0729|M.avium_104 YMLAFATVIPITGWAADRFGTKRLFMGSVLIFTLGSLLCAVAPNILLLIL
* * :. :: . .* * : : .: :*. .* : :
Mflv_1730|M.gilvum_PYR-GCK ARFLQGVGGSMLNPVALSIISQIFTKPVERARALGIWGGVTGISMAAGPI
Mvan_5021|M.vanbaalenii_PYR-1 ARLLQGIGGSMLNPVALSIISQIFTQPVERARALGIWGGVTGISMAAGPI
MSMEG_5670|M.smegmatis_MC2_155 ARLLQAIGGSMLNPVAMSIITQVFTGRVERARAIGVWGSVVGISMALGPL
MAB_0945|M.abscessus_ATCC_1997 ARLLQAVGGSMLNPVALSIISQVFTGRVERARALGFWGAVVGISMALGPI
MMAR_3806|M.marinum_M ARVIQGLGASFISVLSLALLSHAFPDQRMKARAIADWMAIGMVGAASAPA
MUL_3729|M.ulcerans_Agy99 ARVIQGLDASFISVLSLALLSHAFPDQRMKARAIADWMAIGMVGAASAPA
Mb2486|M.bovis_AF2122/97 ARVIQGLGAAFISVLSLALLSHSFPNPRMKARAISNWMAIGMVGAASAPA
Rv2459|M.tuberculosis_H37Rv ARVIQGLGAAFISVLSLALLSHSFPNPRMKARAISNWMAIGMVGAASAPA
TH_2682|M.thermoresistible__bu SRMVAGVGAAFVMPATLSLLTAAYP-RAQRNKAVGIWAAVAGSGAVVGFL
MLBr_01562|M.leprae_Br4923 ARLLQGIGSAIASPTGLALVATTFSKGSARNTATAVFAAMTAIGSVMGLV
MAV_0729|M.avium_104 FRVVQGVGGGMLLPLSFVILTREAGPKRVG-RLMAVGGIPILLGPIGGPI
*.: .:...: : ::: . . .
Mflv_1730|M.gilvum_PYR-GCK VGGLLIETVGWRSVFWINLPICAAAIILTAVFVPESKSQTMRNVDPIGQG
Mvan_5021|M.vanbaalenii_PYR-1 VGGLLIDTIGWRSVFWINLPICAAAILLTAIFVPESKSQTMRNVDPIGQG
MSMEG_5670|M.smegmatis_MC2_155 VGGALIEYVDWRAVFWINLPICALAILLTAIFVRESKSSTMRDVDPVGQG
MAB_0945|M.abscessus_ATCC_1997 VGGLLIQWVGWRAVFWINLPVCVLAFVLTAVFVPETKSATMRDIDPVGQA
MMAR_3806|M.marinum_M LGGLMVETLGWRSVFAVNVPLGAIVLVLTLIGVDESRDPDPTELDWVGQL
MUL_3729|M.ulcerans_Agy99 LGGLMVETLGWRSVFAVSVPLGAIVLVLTLIGVDESRDPDPTELDWVGQL
Mb2486|M.bovis_AF2122/97 LGGLMVDGLGWRSVFLVNVPLGAIVWLLTLVGVDESQDPEPTQLDWVGQL
Rv2459|M.tuberculosis_H37Rv LGGLMVDGLGWRSVFLVNVPLGAIVWLLTLVGVDESQDPEPTQLDWVGQL
TH_2682|M.thermoresistible__bu GTGVLLHFWSWPSIFWA-FTVSGAGLFVLACTVASSRDHRATPLDWPGAV
MLBr_01562|M.leprae_Br4923 VGGALTEVS-WRLAFLVNVPIGLVMIYLARTALHETHKER-MKLDAAGAI
MAV_0729|M.avium_104 LGGWLIGAYGWKWIFLINLPIGLTAFALAALLFPKDRSAPSEALDITGAL
* : * * ..: : . . :. :* *
Mflv_1730|M.gilvum_PYR-GCK LGILFLFGTVFTLIEGPVLG-WTNPRVLAIAAVAVVALIAFLRFES-RRH
Mvan_5021|M.vanbaalenii_PYR-1 LAIMFLFGTVFTLIEGPVLG-WTNPRVVVAAVVVALALVAFLRFES-RRH
MSMEG_5670|M.smegmatis_MC2_155 LGVAFLFGVVFVLIEGPGMG-WTDPRTLAVAATALVAFLAFLRYES-RRH
MAB_0945|M.abscessus_ATCC_1997 LAVLFLFGIVFALIEGPSLG-WATPGLIVVLAVALAAFAVFLRYES-RRR
MMAR_3806|M.marinum_M TFVPGIAVLAYTIIEAPRFQQRSVIVLTSLLLIIVALLWTFIRHER-RAP
MUL_3729|M.ulcerans_Agy99 TFVPGIAVLAYTIIEAPRFQQRSVIVLTSLLLIIVALLRTFIRHER-RAP
Mb2486|M.bovis_AF2122/97 TLIPAVALIAYTIIEAPRFDRQSAGFVAALLLAAGVLLWLFVRHEH-RAA
Rv2459|M.tuberculosis_H37Rv TLIPAVALIAYTIIEAPRFDRQSAGFVAALLLAAGVLLWLFVRHEH-RAA
TH_2682|M.thermoresistible__bu LIGGAVAVFVYGVLEAPVHG-WTHPVVYGSMAAGVALALAFAVVEL-RSA
MLBr_01562|M.leprae_Br4923 LATLACTAAVFAFSMGPEKG-WISLTTIGSGLVALVAAIAFAVVER-TAE
MAV_0729|M.avium_104 LLSPGVAIFLCGVCSIPGRHTVADRYVLVPALVGLVLIAAFILHAWYRTE
. * *
Mflv_1730|M.gilvum_PYR-GCK DPFLDLRFFRSIPFTTATINAISAFAAWGAFLFMMSLYLQGERGFSAMQT
Mvan_5021|M.vanbaalenii_PYR-1 DPFLDLRFFRSIPFTTATVIAISAFAAWGAFLFLMSLYLQGERGFSAMHT
MSMEG_5670|M.smegmatis_MC2_155 DPFIDLRFFRSVPFASATLVAVCAFAAYGAFLFMMSLYLQSERGYSAMFT
MAB_0945|M.abscessus_ATCC_1997 HPFIDLRFFRSIPFASATLTAICACMAWSAFLFTMSLYLQGQRHFSAMHT
MMAR_3806|M.marinum_M FPLIDLQLFTEPVYRSVLIVYFVVMSCFFGTLMVITQFFQNVRDLSPLHA
MUL_3729|M.ulcerans_Agy99 FPLIDLQLFTEPVYRSVLIVYFVVMSCFFGTLMVITQFFQNVRDLSPLHA
Mb2486|M.bovis_AF2122/97 FPLVDLKLFAEPLYRSVLIVYFVVMSCFFGTLMVITQHFQNVRDLSPLHA
Rv2459|M.tuberculosis_H37Rv FPLVDLKLFAEPLYRSVLIVYFVVMSCFFGTLMVITQHFQNVRDLSPLHA
TH_2682|M.thermoresistible__bu HPLLDIRLFAKPDFTTGAVGVTFFFLANFGFFFVSMQYMQLMLGYSALQT
MLBr_01562|M.leprae_Br4923 NPVVPFDLFRDRNRLVTFIAIFLAGGVIFSLTVSIGLYIQDILGYSALRA
MAV_0729|M.avium_104 HPLIDLRLFRNPVVTQVNVTLLVFAAASVGVGLLVPSYFQIVGHETPMQS
*.: : :* . : . . .:* :.: :
Mflv_1730|M.gilvum_PYR-GCK GLIYLPIALGALFCSPLSGRLVGRYGARPSLVAAGILITTAATL-LTLLT
Mvan_5021|M.vanbaalenii_PYR-1 GLIYLPIAIGALLFSPLSGRLVGRYGARPSLVIAGVTITAAATM-LTFLT
MSMEG_5670|M.smegmatis_MC2_155 GLIYLPIAIGALIFSPLSGRMVGRFGSRPSLVSAGVLITAATVM-LAQMT
MAB_0945|M.abscessus_ATCC_1997 GLIYLPIAVGALVFSPISGRMVGRFGARPSLLAAGTLFLTASLL-LTRVS
MMAR_3806|M.marinum_M GLMMLPVPAGFGMASLLAGAAVNKWGPRLPVVTCLAAMVTGLVL-FVTAM
MUL_3729|M.ulcerans_Agy99 GLMMLPVPAGFGMASLLAGAAVNKWGPRLPVVTCLAAMVTGLVL-FVTAM
Mb2486|M.bovis_AF2122/97 GLMMLPVPAGFGVASLLAGRAVNKWGPQLPVLTCLAAMFIGLAI-FAISM
Rv2459|M.tuberculosis_H37Rv GLMMLPVPAGFGVASLLAGRAVNKWGPQLPVLTCLAAMFIGLAI-FAISM
TH_2682|M.thermoresistible__bu AFALTPLTIPLLLLSVTTQWYLPRLGLRAVISTGLLLIAAGLFY-ARTLE
MLBr_01562|M.leprae_Br4923 GIGFIPFVIAMGIGLGVSSQLVSRFSPRVLTIGGGWLLMVAMLYGWAFMN
MAV_0729|M.avium_104 GLHMLPIGVGAVLTMPLGGAVMDKHGPGKIVLTGLPLMAVGLAVFTYGVA
.: *. . : : . : .
Mflv_1730|M.gilvum_PYR-GCK ATTPVWH-LLIVFAVFGVGFSMVNAPITNAAVSGMPLDRAGAASAVTSTS
Mvan_5021|M.vanbaalenii_PYR-1 ATTPVWS-LLMVFAVFGIGFSMVNAPVTNAAVSGMPLDRAGAASAVTSTS
MSMEG_5670|M.smegmatis_MC2_155 ATTPVWL-LLVIFAVFGIGFALVNAPITTAAVSGMPLDRAGAASAVASTS
MAB_0945|M.abscessus_ATCC_1997 EATPIWE-LLVTFAIFGAGFAMVNAPITNAAVSGMPLDRAGAASAVTSTS
MMAR_3806|M.marinum_M GHVPALA-LMG-LTVFGAGAGGSVTPLLHLGMTKVDDHRAGMAAGLLNLQ
MUL_3729|M.ulcerans_Agy99 GHVPALA-LMG-LTVFGAGAGGSVTPLLHLGMTKVDDHRAGMAAGLLNLQ
Mb2486|M.bovis_AF2122/97 DHAHPVA-LVG-LTIFGAGAGGCATPLLHLGMTKVDDGRAGMAAGMLNLQ
Rv2459|M.tuberculosis_H37Rv DHAHPVA-LVG-LTIFGAGAGGCATPLLHLGMTKVDDGRAGMAAGMLNLQ
TH_2682|M.thermoresistible__bu IASPYLD-LAVPLLIMSTGIGLCTAPSTSAIMGAVPDEKHGVASAVNDTT
MLBr_01562|M.leprae_Br4923 RGVPYFPNLLAPIVVGGIGIGMAVVPLTLSAIAGVGFDRIGPVSAIALML
MAV_0729|M.avium_104 RQAAYSPVLVCGLAIMGLGIGLTTTPLSAALMQALAPHQVARGTTLISVN
* : : . * . .* : : : . : :
Mflv_1730|M.gilvum_PYR-GCK RQVGVSIGVALCGSVAGAAMAGSGTDFA----------TAARPLWFVCIA
Mvan_5021|M.vanbaalenii_PYR-1 RQVGVSIGVALCGSLAGSAMATGGADFA----------AAARPLWFVCMA
MSMEG_5670|M.smegmatis_MC2_155 RQVGVSIGVALCGSVAGTALAGTGVDFA----------AASRPLWLICTA
MAB_0945|M.abscessus_ATCC_1997 RQVGVSIGVALCGSIG------------------------TPALWFMCAG
MMAR_3806|M.marinum_M RSMGGIFGVAFLGSILAAWLGATLPDSM----------EDDLPDPVVRSI
MUL_3729|M.ulcerans_Agy99 RSMGGIFGVAFLGSILAAWLGATLPDSM----------EDDLPDPVVRSI
Mb2486|M.bovis_AF2122/97 RSLGGIFGVAFLGTIVAAWLGAALPNTM----------ADEIPDPIARAI
Rv2459|M.tuberculosis_H37Rv RSLGGIFGVAFLGTIVAAWLGAALPNTM----------ADEIPDPIARAI
TH_2682|M.thermoresistible__bu REIGAALGIAVAGSVLAAEYGDRLRPHLGALPEPVRQAASNSLAEALEAA
MLBr_01562|M.leprae_Br4923 QSLGGPLVLAVIQAVITSRTLYLGGTTG---------PVKFMNDAQLRAL
MAV_0729|M.avium_104 QQVGGSIGAALMAVILTNQFNRNPALMA----------ANEAAGMHPVTG
:.:* : *. :
Mflv_1730|M.gilvum_PYR-GCK LGLVILAVGFFSTSQRAVRSAERLAPLVAGAPDPVNGAHVR---------
Mvan_5021|M.vanbaalenii_PYR-1 LGLVILGLGLFATSQRALRSAERLAPLVSGAPEPVGGAHVR---------
MSMEG_5670|M.smegmatis_MC2_155 LGVVIVAIGIVSTSPWALRSAERLAPLIGQHHRPAEVAHAR---------
MAB_0945|M.abscessus_ATCC_1997 LGLLIATLGIVSTSPAAVRSAQRLAPLIEGT-TAREMSRVG---------
MMAR_3806|M.marinum_M VVDTIVDSANPHAHAAFIGPRHRITSAQETNIVSAADSDFMQGIRIALGC
MUL_3729|M.ulcerans_Agy99 VVDTIVDSANPHAHAAFIGPRHRITSAQETNIVSAADSDFMQGIRIALGC
Mb2486|M.bovis_AF2122/97 VVDVIVDSANPHAHAAFIGPGHRITAAQEDEIVLAADAVFVSGIKLALGG
Rv2459|M.tuberculosis_H37Rv VVDVIVDSANPHAHAAFIGPGHRITAAQEDEIVLAADAVFVSGIKLALGG
TH_2682|M.thermoresistible__bu RQLGPQGARLAEFAQSAFLEAMHVSLIVLGALCALAAAFVAVWAPGRDGR
MLBr_01562|M.leprae_Br4923 DHGYTYGLLWVAGAVVIVGVAALFIGYTPEQVAYAQEVKEAVDAGEL---
MAV_0729|M.avium_104 KRGLPVDPSTVPRPAMTPELAGHVSHHLSHAYTAVFVLAVVLVACTIIPA
.
Mflv_1730|M.gilvum_PYR-GCK ---------------------------------------------
Mvan_5021|M.vanbaalenii_PYR-1 ---------------------------------------------
MSMEG_5670|M.smegmatis_MC2_155 ---------------------------------------------
MAB_0945|M.abscessus_ATCC_1997 ---------------------------------------------
MMAR_3806|M.marinum_M ASVLLAAAFVLGLRRFPRPDSDESPDPDESQLAGSDLD-------
MUL_3729|M.ulcerans_Agy99 ASVLLAAAFVLGFRRFACPDSDESPDPDESQLAGSDLD-------
Mb2486|M.bovis_AF2122/97 AAVLLTGAFVLGWTRFPRTPAS-----------------------
Rv2459|M.tuberculosis_H37Rv AAVLLTGAFVLGWTRFPRTPAS-----------------------
TH_2682|M.thermoresistible__bu QYGFVERWTSRWSGEEAGGAVAEHDDGGVRAATGDGWEHGTVDDP
MLBr_01562|M.leprae_Br4923 ---------------------------------------------
MAV_0729|M.avium_104 SFLPRKPPSPPAGD-------------------------------