For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
TPRRKAIILVSCCLSLLIVSMDATIVNVAIPSIRDDLSATPAQMQWVVDVYTLVLASLLMLSGATGDRFG RRRVFQIGLAVFALGSLACSLAPTIDALIGARLLQGIGGSMLNPVALSIISQIFTQPVERARALGIWGGV TGISMAAGPIVGGLLIDTIGWRSVFWINLPICAAAILLTAIFVPESKSQTMRNVDPIGQGLAIMFLFGTV FTLIEGPVLGWTNPRVVVAAVVVALALVAFLRFESRRHDPFLDLRFFRSIPFTTATVIAISAFAAWGAFL FLMSLYLQGERGFSAMHTGLIYLPIAIGALLFSPLSGRLVGRYGARPSLVIAGVTITAAATMLTFLTATT PVWSLLMVFAVFGIGFSMVNAPVTNAAVSGMPLDRAGAASAVTSTSRQVGVSIGVALCGSLAGSAMATGG ADFAAAARPLWFVCMALGLVILGLGLFATSQRALRSAERLAPLVSGAPEPVGGAHVR*
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. vanbaalenii PYR-1 | Mvan_5021 | - | - | 100% (478) | EmrB/QacA family drug resistance transporter |
M. vanbaalenii PYR-1 | Mvan_0523 | - | 0.0 | 66.81% (467) | EmrB/QacA family drug resistance transporter |
M. vanbaalenii PYR-1 | Mvan_1284 | - | 4e-62 | 33.10% (423) | major facilitator superfamily transporter |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb2361c | - | 1e-75 | 35.94% (409) | integral membrane transport protein |
M. gilvum PYR-GCK | Mflv_1730 | - | 0.0 | 88.49% (478) | EmrB/QacA family drug resistance transporter |
M. tuberculosis H37Rv | Rv2333c | - | 6e-75 | 35.94% (409) | integral membrane transport protein |
M. leprae Br4923 | MLBr_01562 | - | 4e-50 | 30.73% (397) | putative transmembrane efflux protein |
M. abscessus ATCC 19977 | MAB_0945 | - | 0.0 | 67.45% (467) | EmrB/QacA family drug resistance transporter |
M. marinum M | MMAR_1146 | - | 2e-80 | 38.08% (407) | integral membrane transport protein |
M. avium 104 | MAV_1387 | - | 4e-58 | 34.01% (397) | drug transporter |
M. smegmatis MC2 155 | MSMEG_5670 | - | 0.0 | 73.43% (478) | efflux membrane protein |
M. thermoresistible (build 8) | TH_3965 | - | 4e-58 | 34.20% (424) | PUTATIVE drug transporter |
M. ulcerans Agy99 | MUL_0911 | - | 6e-81 | 36.72% (433) | integral membrane transport protein |
CLUSTAL 2.0.9 multiple sequence alignment Mvan_5021|M.vanbaalenii_PYR-1 -------------------------------------------------M Mflv_1730|M.gilvum_PYR-GCK -------------------------------------------------M MSMEG_5670|M.smegmatis_MC2_155 ------------------------------------------MNETVGAL MAB_0945|M.abscessus_ATCC_1997 ------------------------------------------MEAAVGAL MAV_1387|M.avium_104 -------------------------------------------------- TH_3965|M.thermoresistible__bu ----------------------------VTSVDAGRSTMSEVFTAYAPRS Mb2361c|M.bovis_AF2122/97 -------------------------------------------------- Rv2333c|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_1146|M.marinum_M --------------------------------------------MRIQPV MUL_0911|M.ulcerans_Agy99 --------------------------------------------MRIQPV MLBr_01562|M.leprae_Br4923 MVTLYDHERAVHNWTAARSDRPAPSRLTQQVEPASERTSKYPTLLPSGRF Mvan_5021|M.vanbaalenii_PYR-1 TPRRKAIILVSCCLSLLIVSMDATIVNVAIPSIRDDLSATPAQMQWVVDV Mflv_1730|M.gilvum_PYR-GCK TPRRKAIILVSCCLSLLIVSMDATIVNVAIPSIRADLSASPAQMQWVVDI MSMEG_5670|M.smegmatis_MC2_155 SARRKAIILVSCCLSLLIVSMDATIVNVAIPSIRSDLGASPSQLQWVIDV MAB_0945|M.abscessus_ATCC_1997 SERRKIVILGSCCLSLLIVSMDSTIVNVALPTIRADFGATTSQLQWVIDI MAV_1387|M.avium_104 -----------MMIGFFMIMVDSTIVAIANPTIMADLHIGYDTVVWVTSA TH_3965|M.thermoresistible__bu AAANPWHALWAMLIGFFMILVDATIVPVANLEIMADLGADYTAVIWVTSA Mb2361c|M.bovis_AF2122/97 MNRTQLLTLIATGLGLFMIFLDALIVNVALPDIQRSFAVGEDGLQWVVAS Rv2333c|M.tuberculosis_H37Rv MNRTQLLTLIATGLGLFMIFLDALIVNVALPDIQRSFAVGEDGLQWVVAS MMAR_1146|M.marinum_M FRDHPIPALAVICLSVFVISVDATIVNVALPTLSRQLGADTAQLQWIVDA MUL_0911|M.ulcerans_Agy99 FRDHPILALAVICLSVFVISVDATIVNVALPTLSRELGADTAQLQWIVDA MLBr_01562|M.leprae_Br4923 PSGRFIAAVIVIGGMQLLATMDSTVAIVALPKIQNELSLSDAGRSWGITA :: :*: :. :* : .: * Mvan_5021|M.vanbaalenii_PYR-1 YTLVLASLLMLSGATGDRFGRRRVFQIGLAVFALGSLACSLAPTIDALIG Mflv_1730|M.gilvum_PYR-GCK YTLVLASLLMLSGATGDRFGRRRLFQIGLTVFALGSLACSLAPTIDTLIG MSMEG_5670|M.smegmatis_MC2_155 YTLVLASLLLLAGATGDRFGRRRTFHLGLTVFAVASLLCSVAPNIETLIA MAB_0945|M.abscessus_ATCC_1997 YTLGLASLLMLSGAAGDRLGRRKVFHLGLSIFAIGSLLCSVAPTVGLLIA MAV_1387|M.avium_104 YLLGYAVVLLVAGRLGDRFGTKNLYLIGLAVFTVASVWCGLAGSAAMLIA TH_3965|M.thermoresistible__bu YLLAYAVPLLIAGRLGDRFGPRTMYLIGLAIFTAASLWCGLAGTIGMLIA Mb2361c|M.bovis_AF2122/97 YSLGMAVFIMSAATLADLYGRRRWYLIGVSLFTLGSIACGLAPSIAVLTT Rv2333c|M.tuberculosis_H37Rv YSLGMAVFIMSAATLADLDGRRRWYLIGVSLFTLGSIACGLAPSIAVLTT MMAR_1146|M.marinum_M YTLVMSGLLLSAGSLSDRYGRRGWLSAGLILFALTSALAAQVNSADTLIA MUL_0911|M.ulcerans_Agy99 YTLVMSGLLLSAGSLSDRYGRRGWLSAGLILFALTSALAAQVNSADTLVA MLBr_01562|M.leprae_Br4923 YVLTFGGLMLLGGRLGDTIGRKRTFIVGVALFTISSVLCAVAWDEVTLVI * * . :: .. .* * : *: :*: * .. . * Mvan_5021|M.vanbaalenii_PYR-1 ARLLQGIGGSMLNPVALSIISQIFTQPVERARALGIWGGVTGISMAAGPI Mflv_1730|M.gilvum_PYR-GCK ARFLQGVGGSMLNPVALSIISQIFTKPVERARALGIWGGVTGISMAAGPI MSMEG_5670|M.smegmatis_MC2_155 ARLLQAIGGSMLNPVAMSIITQVFTGRVERARAIGVWGSVVGISMALGPL MAB_0945|M.abscessus_ATCC_1997 ARLLQAVGGSMLNPVALSIISQVFTGRVERARALGFWGAVVGISMALGPI MAV_1387|M.avium_104 ARVVQGVGAGVMTPQTLSTITRIFPAERR-GVAVSVWSATAGAASLAGPL TH_3965|M.thermoresistible__bu ARVLQGLGAALLTPQTLSMITRIFPADRR-GVPMGVWGATAGVATLIGPL Mb2361c|M.bovis_AF2122/97 ARGAQGLGAAAVSVTSLALVSAAFPEAKEKARAIGIWTAIASIGTTTGPT Rv2333c|M.tuberculosis_H37Rv ARGAQGLGAAAVSVTSLALVSAAFPEAKEKARAIGIWTAIASIGTTTGPT MMAR_1146|M.marinum_M ARAAMGVGAAVIFPTTLGLITNIFTDPVPRAKAIGLWTAMVGVGVAVGPI MUL_0911|M.ulcerans_Agy99 ARAAMGVGAAVIFPTTLGLITNIFTDPVPRAKAIGLWTAMVGVGVAVGPI MLBr_01562|M.leprae_Br4923 ARLLQGIGSAIASPTGLALVATTFSKGSARNTATAVFAAMTAIGSVMGLV ** .:*.. :. :: *. . ..: . .. . * Mvan_5021|M.vanbaalenii_PYR-1 VGGLLIDTIGWRSVFWINLPICAAAILLTAIFVPESKSQTMRNVDPIGQG Mflv_1730|M.gilvum_PYR-GCK VGGLLIETVGWRSVFWINLPICAAAIILTAVFVPESKSQTMRNVDPIGQG MSMEG_5670|M.smegmatis_MC2_155 VGGALIEYVDWRAVFWINLPICALAILLTAIFVRESKSSTMRDVDPVGQG MAB_0945|M.abscessus_ATCC_1997 VGGLLIQWVGWRAVFWINLPVCVLAFVLTAVFVPETKSATMRDIDPVGQA MAV_1387|M.avium_104 AGGVLVDGLGWQWIFFVNVPIGVLGLVLAYWLVPVLP-TQSHRFDLVGVG TH_3965|M.thermoresistible__bu AGGVLVDGLGWQWIFIVNVPIGIAGLVLGARLMPRLP-RQDQGFDVLGMV Mb2361c|M.bovis_AF2122/97 LGGLLVDQWGWRSIFYVNLPMGALVLFLTLCYVEESCNERARRFDLSGQL Rv2333c|M.tuberculosis_H37Rv LGGLLVDQWGWRSIFYVNLPMGALVLFLTLCYVEESCNERARRFDLSGQL MMAR_1146|M.marinum_M TGGWLLEHFSWGSIFLVNVPIAVAAMAGAILFVPTSRDPAAPRVDVPGLM MUL_0911|M.ulcerans_Agy99 TGGWLLEHFSWGSIFLVNVPIAVAAMAGAILFVPTSRDPAAPRVDVPGLM MLBr_01562|M.leprae_Br4923 VGGALTEVS-WRLAFLVNVPIGLVMIYLARTALHETHKERMK-LDAAGAI ** * : * * :*:*: : : .* * Mvan_5021|M.vanbaalenii_PYR-1 LAIMFLFGTVFTLIEGPVLGWTNPRVVVAAVVVALALVAFLRFESRRHDP Mflv_1730|M.gilvum_PYR-GCK LGILFLFGTVFTLIEGPVLGWTNPRVLAIAAVAVVALIAFLRFESRRHDP MSMEG_5670|M.smegmatis_MC2_155 LGVAFLFGVVFVLIEGPGMGWTDPRTLAVAATALVAFLAFLRYESRRHDP MAB_0945|M.abscessus_ATCC_1997 LAVLFLFGIVFALIEGPSLGWATPGLIVVLAVALAAFAVFLRYESRRRHP MAV_1387|M.avium_104 LSGVGMLLIVFGLQQGQAAHWQPWIWALIVAGVGFVTVFVFWQSVNVREP TH_3965|M.thermoresistible__bu LSAVGLFLIVFALQEAQTHRWAPWIWGTLAGGAGVMAMFVIWQSANRRHP Mb2361c|M.bovis_AF2122/97 LFIVAVGALVYAVIEGPQIGWTSVQTIVMLWTAAVGCALFVWLERRSSNP Rv2333c|M.tuberculosis_H37Rv LFIVAVGALVYAVIEGPQIGWTSVQTIVMLWTAAVGCALFVWLERRSSNP MMAR_1146|M.marinum_M LSAVGITALVYTIIEAPNWGWTSTRASGGFIAAAIVLVGFALWERRSSHP MUL_0911|M.ulcerans_Agy99 LSAVGITALVYTIIEAPNWGWTSTRASGGFIAAAIVLVGFALWERRSSHP MLBr_01562|M.leprae_Br4923 LATLACTAAVFAFSMGPEKGWISLTTIGSGLVALVAAIAFAVVERTAENP * *: . . * . . . .* Mvan_5021|M.vanbaalenii_PYR-1 FLDLRFFRSIPFTTATVIAISAFAAWGAFLFLMSLYLQGERGFSAMHTGL Mflv_1730|M.gilvum_PYR-GCK FLDLRFFRSIPFTTATINAISAFAAWGAFLFMMSLYLQGERGFSAMQTGL MSMEG_5670|M.smegmatis_MC2_155 FIDLRFFRSVPFASATLVAVCAFAAYGAFLFMMSLYLQSERGYSAMFTGL MAB_0945|M.abscessus_ATCC_1997 FIDLRFFRSIPFASATLTAICACMAWSAFLFTMSLYLQGQRHFSAMHTGL MAV_1387|M.avium_104 LIPLVIFSDRDFSLCNIGVAIISFAATAMMLPLTFYAQAVCGLSPTRSAL TH_3965|M.thermoresistible__bu LVPLQIFADRNFMLANVGVATIGFVVTAMVLPAMFFAQAVCGLSPTGSAL Mb2361c|M.bovis_AF2122/97 MMDLTLFRDTSYALAIATICTVFFAVYGMLLLTTQFLQNVRGYTPSVTGL Rv2333c|M.tuberculosis_H37Rv MMDLTLFRDTSYALAIATICTVFFAVYGMLLLTTQFLQNVRGYTPSVTGL MMAR_1146|M.marinum_M MLDVSVFANRRFSGGSLAVTAGFLTLFGFIFVITQYFQFIKDYTALQTGV MUL_0911|M.ulcerans_Agy99 MLDVSVFANRRFSGGSLAVTAGFLTLFGFIFVITQYFQFIKDYTALQTGV MLBr_01562|M.leprae_Br4923 VVPFDLFRDRNRLVTFIAIFLAGGVIFSLTVSIGLYIQDILGYSALRAGI .: . .* . . .: . : * :. :.: Mvan_5021|M.vanbaalenii_PYR-1 IYLPIAIGALLFSPLSGRLVGRYGARPSLVIAG-VTITAAATMLTFLTAT Mflv_1730|M.gilvum_PYR-GCK IYLPIALGALFCSPLSGRLVGRYGARPSLVAAG-ILITTAATLLTLLTAT MSMEG_5670|M.smegmatis_MC2_155 IYLPIAIGALIFSPLSGRMVGRFGSRPSLVSAG-VLITAATVMLAQMTAT MAB_0945|M.abscessus_ATCC_1997 IYLPIAVGALVFSPISGRMVGRFGARPSLLAAG-TLFLTASLLLTRVSEA MAV_1387|M.avium_104 LIAPMAIANGVFAPFVGKIVDRYHPRPVLGFGFSLLAIALTWLTFEMSPA TH_3965|M.thermoresistible__bu LIAPMAVASGVLAPMAGRIVDRSHPTPVVGFGFSVVAVGLTWLAVEMAPT Mb2361c|M.bovis_AF2122/97 MILPFSAAVAIVSPLVGHLVGRIGARVPILAGLCMLMLGLLMLIFSEHRS Rv2333c|M.tuberculosis_H37Rv MILPFSAAVAIVSPLVGHLVGRIGARVPILAGLCMLMLGLLMLIFSEHRS MMAR_1146|M.marinum_M RLLPVALSIALAAILGPRLVERVGTTAVVAAGLAVFAAALAWAS-TADAT MUL_0911|M.ulcerans_Agy99 RLLPVAFSIALAAILGPRLVERVGTTAVVAAGLAVFAAALAWAS-TADAT MLBr_01562|M.leprae_Br4923 GFIPFVIAMGIGLGVSSQLVSRFSPRVLTIGGGWLLMVAMLYGWAFMNRG *. . . . ::* * . . Mvan_5021|M.vanbaalenii_PYR-1 TPVWS-LLMVFAVFGIGFSMVNAPVTNAAVSGMPLDRAGAASAVTSTSRQ Mflv_1730|M.gilvum_PYR-GCK TPVWH-LLIVFAVFGVGFSMVNAPITNAAVSGMPLDRAGAASAVTSTSRQ MSMEG_5670|M.smegmatis_MC2_155 TPVWL-LLVIFAVFGIGFALVNAPITTAAVSGMPLDRAGAASAVASTSRQ MAB_0945|M.abscessus_ATCC_1997 TPIWE-LLVTFAIFGAGFAMVNAPITNAAVSGMPLDRAGAASAVTSTSRQ MAV_1387|M.avium_104 TPIWR-LVLPFFAMGVGMAFVWSPLTATATRNLSAQLAGAGSAVYNSVRQ TH_3965|M.thermoresistible__bu TPIWR-LVLPFVAVGVGMAFIWSPLATTATRQLPLHLSGAGSGVYNTTRQ Mb2361c|M.bovis_AF2122/97 SALVL-VGLGLCGS--GVALCLTPITTVAMTAVPAERAGMASGIMSAQRA Rv2333c|M.tuberculosis_H37Rv SALVL-VGLGLCGS--GVALCLTPITTVAMTAVPAERAGMASGIMSAQRA MMAR_1146|M.marinum_M TPYTQ-IALQMLLLGGGLGLTTAPATEAIMGSLPADRAGVGSAVNDTTRE MUL_0911|M.ulcerans_Agy99 TPYTQ-ITLQMLLLGGGLGLTTAPATEAIMGSLPADRAGVGSAVNDTTRE MLBr_01562|M.leprae_Br4923 VPYFPNLLAPIVVGGIGIGMAVVPLTLSAIAGVGFDRIGPVSAIALMLQS . : : *..: * : : . * *.: : Mvan_5021|M.vanbaalenii_PYR-1 VGVSIGVALCGSLAGS------AMATGGADFAAAARPLWFVCMALGLVIL Mflv_1730|M.gilvum_PYR-GCK VGVSIGVALCGSVAGA------AMAGSGTDFATAARPLWFVCIALGLVIL MSMEG_5670|M.smegmatis_MC2_155 VGVSIGVALCGSVAGT------ALAGTGVDFAAASRPLWLICTALGVVIV MAB_0945|M.abscessus_ATCC_1997 VGVSIGVALCGSIG--------------------TPALWFMCAGLGLLIA MAV_1387|M.avium_104 LGAVLGSAGMAAFMTW------RIGAEMP-GQPGGGGEDSAGPVLPEFLR TH_3965|M.thermoresistible__bu IGSVLGSAGMAAFLTG------RLSAELP-FGATAVPAGEQTRVLPEFLH Mb2361c|M.bovis_AF2122/97 IGSTIGFAVLGSVLAA------WLSATLEPHLERAVPDPVQRHVLAEIII Rv2333c|M.tuberculosis_H37Rv IGSTIGFAVLGSVLAA------WLSATLEPHLERAVPDPVQRHVLAEIII MMAR_1146|M.marinum_M LGGTLGVAIAGSVFAS------VYSGQLGSASTLATLPSDVRSAMKGSMA MUL_0911|M.ulcerans_Agy99 LGGTLGVAIAGSVFAS------VYSGQLGSASALATLPSDVRSAMKGSMA MLBr_01562|M.leprae_Br4923 LGGPLVLAVIQAVITSRTLYLGGTTGPVKFMNDAQLRALDHGYTYGLLWV :* : * :. Mvan_5021|M.vanbaalenii_PYR-1 GLGLFATSQRALRSAERLAPLVSGAPEPVGGAHVR--------------- Mflv_1730|M.gilvum_PYR-GCK AVGFFSTSQRAVRSAERLAPLVAGAPDPVNGAHVR--------------- MSMEG_5670|M.smegmatis_MC2_155 AIGIVSTSPWALRSAERLAPLIGQHHRPAEVAHAR--------------- MAB_0945|M.abscessus_ATCC_1997 TLGIVSTSPAAVRSAQRLAPLIEGT-TAREMSRVG--------------- MAV_1387|M.avium_104 GPFAAAMSQSVLLPAFIALFGIVAALFLVGFRPWAHRDGGTDAFGPDDYG TH_3965|M.thermoresistible__bu APYAAAMAQSMLLPAFVALFGVLAAIFLAGIVLSTPQP---------DAD Mb2361c|M.bovis_AF2122/97 DSANPRAHVGGIVPRRHIEHRDPVAIAEEDFIEG--------------IR Rv2333c|M.tuberculosis_H37Rv DSANPRAHVGGIVPRRHIEHRDPVAIAEEDFIEG--------------IR MMAR_1146|M.marinum_M VAHKVIDQLPAGPAAGVRDAVNHAFLDGLQVATLVCAG------------ MUL_0911|M.ulcerans_Agy99 VAHKVIDQLPAGPAAGVRDAVNHAFLDGLQVATLVCAG------------ MLBr_01562|M.leprae_Br4923 AGAVVIVGVAALFIGYTPEQVAYAQEVKEAVDAGEL-------------- Mvan_5021|M.vanbaalenii_PYR-1 -------------------------------------------------- Mflv_1730|M.gilvum_PYR-GCK -------------------------------------------------- MSMEG_5670|M.smegmatis_MC2_155 -------------------------------------------------- MAB_0945|M.abscessus_ATCC_1997 -------------------------------------------------- MAV_1387|M.avium_104 GDYHDDYDDDDAYVELILVREPEPEAQQRAGQPRRPQPTPAPPADVRRRD TH_3965|M.thermoresistible__bu AQYLDEHDD---YLVIELAR-----------------PDPNPRTDIAVTA Mb2361c|M.bovis_AF2122/97 VALLVATAT---LAVVFLAG-------------WRWFPRDVQTAGSDAKR Rv2333c|M.tuberculosis_H37Rv VALLVATAT---LAVVFLAG-------------WRWFPRDVHTAGSDLSE MMAR_1146|M.marinum_M ----------IALAAAIVVG----------------WLLPARAGQPTPAQ MUL_0911|M.ulcerans_Agy99 ----------IALAAAIVVG----------------WLLPARAGQPTPAQ MLBr_01562|M.leprae_Br4923 -------------------------------------------------- Mvan_5021|M.vanbaalenii_PYR-1 -------------------------------------------------- Mflv_1730|M.gilvum_PYR-GCK -------------------------------------------------- MSMEG_5670|M.smegmatis_MC2_155 -------------------------------------------------- MAB_0945|M.abscessus_ATCC_1997 -------------------------------------------------- MAV_1387|M.avium_104 PVESRRSVLDERPAQVQPIGFAHNGSHVDGGKRLRQVAVRRAPKPGPPAD TH_3965|M.thermoresistible__bu VIPALRPTLRP--------------------------TLR--PSLGPPGG Mb2361c|M.bovis_AF2122/97 --EAAYSDDRR--------------------------------VRG---- Rv2333c|M.tuberculosis_H37Rv RLPTAMTVECA--------------------------------VSHMPGA MMAR_1146|M.marinum_M TEPALAQA------------------------------------------ MUL_0911|M.ulcerans_Agy99 TEPALAQV------------------------------------------ MLBr_01562|M.leprae_Br4923 -------------------------------------------------- Mvan_5021|M.vanbaalenii_PYR-1 ----------------------------------------------- Mflv_1730|M.gilvum_PYR-GCK ----------------------------------------------- MSMEG_5670|M.smegmatis_MC2_155 ----------------------------------------------- MAB_0945|M.abscessus_ATCC_1997 ----------------------------------------------- MAV_1387|M.avium_104 RFTRPPRRHHPGPAGHHLGEGESLRGQHHRPDPDDDPTGYGRHSSGN TH_3965|M.thermoresistible__bu PVVQP-------------NNTAALR---------------------- Mb2361c|M.bovis_AF2122/97 ----------------------------------------------- Rv2333c|M.tuberculosis_H37Rv TWCRLWPA--------------------------------------- MMAR_1146|M.marinum_M ----------------------------------------------- MUL_0911|M.ulcerans_Agy99 ----------------------------------------------- MLBr_01562|M.leprae_Br4923 -----------------------------------------------