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MEAAVGALSERRKIVILGSCCLSLLIVSMDSTIVNVALPTIRADFGATTSQLQWVIDIYTLGLASLLMLS GAAGDRLGRRKVFHLGLSIFAIGSLLCSVAPTVGLLIAARLLQAVGGSMLNPVALSIISQVFTGRVERAR ALGFWGAVVGISMALGPIVGGLLIQWVGWRAVFWINLPVCVLAFVLTAVFVPETKSATMRDIDPVGQALA VLFLFGIVFALIEGPSLGWATPGLIVVLAVALAAFAVFLRYESRRRHPFIDLRFFRSIPFASATLTAICA CMAWSAFLFTMSLYLQGQRHFSAMHTGLIYLPIAVGALVFSPISGRMVGRFGARPSLLAAGTLFLTASLL LTRVSEATPIWELLVTFAIFGAGFAMVNAPITNAAVSGMPLDRAGAASAVTSTSRQVGVSIGVALCGSIG TPALWFMCAGLGLLIATLGIVSTSPAAVRSAQRLAPLIEGTTAREMSRVG
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. abscessus ATCC 19977 | MAB_0945 | - | - | 100% (470) | EmrB/QacA family drug resistance transporter |
M. abscessus ATCC 19977 | MAB_1396 | - | 4e-67 | 36.04% (419) | EmrB/QacA family drug resistance transporter |
M. abscessus ATCC 19977 | MAB_1935 | - | 1e-60 | 33.42% (404) | putative drug resistance transporter |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb2361c | - | 5e-75 | 36.19% (409) | integral membrane transport protein |
M. gilvum PYR-GCK | Mflv_1730 | - | 0.0 | 68.95% (467) | EmrB/QacA family drug resistance transporter |
M. tuberculosis H37Rv | Rv2333c | - | 1e-74 | 36.19% (409) | integral membrane transport protein |
M. leprae Br4923 | MLBr_01562 | - | 5e-48 | 30.10% (402) | putative transmembrane efflux protein |
M. marinum M | MMAR_3642 | - | 1e-76 | 36.59% (410) | integral membrane transport protein |
M. avium 104 | MAV_1387 | - | 9e-59 | 33.16% (395) | drug transporter |
M. smegmatis MC2 155 | MSMEG_5670 | - | 0.0 | 70.34% (472) | efflux membrane protein |
M. thermoresistible (build 8) | TH_3965 | - | 2e-60 | 33.83% (405) | PUTATIVE drug transporter |
M. ulcerans Agy99 | MUL_0911 | - | 1e-76 | 34.23% (444) | integral membrane transport protein |
M. vanbaalenii PYR-1 | Mvan_5021 | - | 0.0 | 67.45% (467) | EmrB/QacA family drug resistance transporter |
CLUSTAL 2.0.9 multiple sequence alignment Mflv_1730|M.gilvum_PYR-GCK -------------------------------------------------M Mvan_5021|M.vanbaalenii_PYR-1 -------------------------------------------------M MSMEG_5670|M.smegmatis_MC2_155 ------------------------------------------MNETVGAL MAB_0945|M.abscessus_ATCC_1997 ------------------------------------------MEAAVGAL MAV_1387|M.avium_104 -------------------------------------------------- TH_3965|M.thermoresistible__bu ----------------------------VTSVDAGRSTMSEVFTAYAPRS Mb2361c|M.bovis_AF2122/97 -------------------------------------------------- Rv2333c|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_3642|M.marinum_M -------------------------------------------------- MUL_0911|M.ulcerans_Agy99 --------------------------------------------MRIQPV MLBr_01562|M.leprae_Br4923 MVTLYDHERAVHNWTAARSDRPAPSRLTQQVEPASERTSKYPTLLPSGRF Mflv_1730|M.gilvum_PYR-GCK TPRRKAIILVSCCLSLLIVSMDATIVNVAIPSIRADLSASPAQMQWVVDI Mvan_5021|M.vanbaalenii_PYR-1 TPRRKAIILVSCCLSLLIVSMDATIVNVAIPSIRDDLSATPAQMQWVVDV MSMEG_5670|M.smegmatis_MC2_155 SARRKAIILVSCCLSLLIVSMDATIVNVAIPSIRSDLGASPSQLQWVIDV MAB_0945|M.abscessus_ATCC_1997 SERRKIVILGSCCLSLLIVSMDSTIVNVALPTIRADFGATTSQLQWVIDI MAV_1387|M.avium_104 -----------MMIGFFMIMVDSTIVAIANPTIMADLHIGYDTVVWVTSA TH_3965|M.thermoresistible__bu AAANPWHALWAMLIGFFMILVDATIVPVANLEIMADLGADYTAVIWVTSA Mb2361c|M.bovis_AF2122/97 MNRTQLLTLIATGLGLFMIFLDALIVNVALPDIQRSFAVGEDGLQWVVAS Rv2333c|M.tuberculosis_H37Rv MNRTQLLTLIATGLGLFMIFLDALIVNVALPDIQRSFAVGEDGLQWVVAS MMAR_3642|M.marinum_M MNRTQLLTIFATGLGLFMIFLDAFIVNVALPDIQNTFGVGEDGLQWVVAA MUL_0911|M.ulcerans_Agy99 FRDHPILALAVICLSVFVISVDATIVNVALPTLSRELGADTAQLQWIVDA MLBr_01562|M.leprae_Br4923 PSGRFIAAVIVIGGMQLLATMDSTVAIVALPKIQNELSLSDAGRSWGITA :: :*: :. :* : : * Mflv_1730|M.gilvum_PYR-GCK YTLVLASLLMLSGATGDRFGRRRLFQIGLTVFALGSLACSLAPTIDTLIG Mvan_5021|M.vanbaalenii_PYR-1 YTLVLASLLMLSGATGDRFGRRRVFQIGLAVFALGSLACSLAPTIDALIG MSMEG_5670|M.smegmatis_MC2_155 YTLVLASLLLLAGATGDRFGRRRTFHLGLTVFAVASLLCSVAPNIETLIA MAB_0945|M.abscessus_ATCC_1997 YTLGLASLLMLSGAAGDRLGRRKVFHLGLSIFAIGSLLCSVAPTVGLLIA MAV_1387|M.avium_104 YLLGYAVVLLVAGRLGDRFGTKNLYLIGLAVFTVASVWCGLAGSAAMLIA TH_3965|M.thermoresistible__bu YLLAYAVPLLIAGRLGDRFGPRTMYLIGLAIFTAASLWCGLAGTIGMLIA Mb2361c|M.bovis_AF2122/97 YSLGMAVFIMSAATLADLYGRRRWYLIGVSLFTLGSIACGLAPSIAVLTT Rv2333c|M.tuberculosis_H37Rv YSLGMAVFIMSAATLADLDGRRRWYLIGVSLFTLGSIACGLAPSIAVLTT MMAR_3642|M.marinum_M YSLGMAVFIMSAATLADRYGRRRWYLMGIALFTLGSIACGLAPSIAMLTA MUL_0911|M.ulcerans_Agy99 YTLVMSGLLLSAGSLSDRYGRRGWLSAGLILFALTSALAAQVNSADTLVA MLBr_01562|M.leprae_Br4923 YVLTFGGLMLLGGRLGDTIGRKRTFIVGVALFTISSVLCAVAWDEVTLVI * * . :: .. .* * : *: :*: * .. . * Mflv_1730|M.gilvum_PYR-GCK ARFLQGVGGSMLNPVALSIISQIFTKPVERARALGIWGGVTGISMAAGPI Mvan_5021|M.vanbaalenii_PYR-1 ARLLQGIGGSMLNPVALSIISQIFTQPVERARALGIWGGVTGISMAAGPI MSMEG_5670|M.smegmatis_MC2_155 ARLLQAIGGSMLNPVAMSIITQVFTGRVERARAIGVWGSVVGISMALGPL MAB_0945|M.abscessus_ATCC_1997 ARLLQAVGGSMLNPVALSIISQVFTGRVERARALGFWGAVVGISMALGPI MAV_1387|M.avium_104 ARVVQGVGAGVMTPQTLSTITRIFP-AERRGVAVSVWSATAGAASLAGPL TH_3965|M.thermoresistible__bu ARVLQGLGAALLTPQTLSMITRIFP-ADRRGVPMGVWGATAGVATLIGPL Mb2361c|M.bovis_AF2122/97 ARGAQGLGAAAVSVTSLALVSAAFPEAKEKARAIGIWTAIASIGTTTGPT Rv2333c|M.tuberculosis_H37Rv ARGAQGLGAAAVSVTSLALVSAAFPEAKEKARAIGIWTAIASIGTTTGPT MMAR_3642|M.marinum_M ARGIQGFGAATVSVTSLALVSAAFPNPKEKARAIGIWTAVASVGTATGPT MUL_0911|M.ulcerans_Agy99 ARAAMGVGAAVIFPTTLGLITNIFTDPVPRAKAIGLWTAMVGVGVAVGPI MLBr_01562|M.leprae_Br4923 ARLLQGIGSAIASPTGLALVATTFSKGSARNTATAVFAAMTAIGSVMGLV ** ..*.. :. :: *. : . ..: . .. . * Mflv_1730|M.gilvum_PYR-GCK VGGLLIETVGWRSVFWINLPICAAAIILTAVFVPESKSQTMRNVDPIGQG Mvan_5021|M.vanbaalenii_PYR-1 VGGLLIDTIGWRSVFWINLPICAAAILLTAIFVPESKSQTMRNVDPIGQG MSMEG_5670|M.smegmatis_MC2_155 VGGALIEYVDWRAVFWINLPICALAILLTAIFVRESKSSTMRDVDPVGQG MAB_0945|M.abscessus_ATCC_1997 VGGLLIQWVGWRAVFWINLPVCVLAFVLTAVFVPETKSATMRDIDPVGQA MAV_1387|M.avium_104 AGGVLVDGLGWQWIFFVNVPIGVLGLVLAYWLVP-VLPTQSHRFDLVGVG TH_3965|M.thermoresistible__bu AGGVLVDGLGWQWIFIVNVPIGIAGLVLGARLMP-RLPRQDQGFDVLGMV Mb2361c|M.bovis_AF2122/97 LGGLLVDQWGWRSIFYVNLPMGALVLFLTLCYVEESCNERARRFDLSGQL Rv2333c|M.tuberculosis_H37Rv LGGLLVDQWGWRSIFYVNLPMGALVLFLTLCYVEESCNERARRFDLSGQL MMAR_3642|M.marinum_M LGGLLVDTWGWRSIFYVNVPMGVFVILLTVGFVAESRNARAGRLDLSGQA MUL_0911|M.ulcerans_Agy99 TGGWLLEHFSWGSIFLVNVPIAVAAMAGAILFVPTSRDPAAPRVDVPGLM MLBr_01562|M.leprae_Br4923 VGGALTEVS-WRLAFLVNVPIGLVMIYLARTALHETHKERMK-LDAAGAI ** * : * * :*:*: : : .* * Mflv_1730|M.gilvum_PYR-GCK LGILFLFGTVFTLIEGPVLGWTNPRVLAIAAVAVVALIAFLRFESRRHDP Mvan_5021|M.vanbaalenii_PYR-1 LAIMFLFGTVFTLIEGPVLGWTNPRVVVAAVVVALALVAFLRFESRRHDP MSMEG_5670|M.smegmatis_MC2_155 LGVAFLFGVVFVLIEGPGMGWTDPRTLAVAATALVAFLAFLRYESRRHDP MAB_0945|M.abscessus_ATCC_1997 LAVLFLFGIVFALIEGPSLGWATPGLIVVLAVALAAFAVFLRYESRRRHP MAV_1387|M.avium_104 LSGVGMLLIVFGLQQGQAAHWQPWIWALIVAGVGFVTVFVFWQSVNVREP TH_3965|M.thermoresistible__bu LSAVGLFLIVFALQEAQTHRWAPWIWGTLAGGAGVMAMFVIWQSANRRHP Mb2361c|M.bovis_AF2122/97 LFIVAVGALVYAVIEGPQIGWTSVQTIVMLWTAAVGCALFVWLERRSSNP Rv2333c|M.tuberculosis_H37Rv LFIVAVGALVYAVIEGPQIGWTSVQTIVMLWTAAVGCALFVWLERRSSNP MMAR_3642|M.marinum_M LFIVTVGAFVYAVIEGPQIGWTSPLILTLLMTAAVGCALFLWLEGRSADP MUL_0911|M.ulcerans_Agy99 LSAVGITALVYTIIEAPNWGWTSTRASGGFIAAAIVLVGFALWERRSSHP MLBr_01562|M.leprae_Br4923 LATLACTAAVFAFSMGPEKGWISLTTIGSGLVALVAAIAFAVVERTAENP * *: . . * . . . .* Mflv_1730|M.gilvum_PYR-GCK FLDLRFFRSIPFTTATINAISAFAAWGAFLFMMSLYLQGERGFSAMQTGL Mvan_5021|M.vanbaalenii_PYR-1 FLDLRFFRSIPFTTATVIAISAFAAWGAFLFLMSLYLQGERGFSAMHTGL MSMEG_5670|M.smegmatis_MC2_155 FIDLRFFRSVPFASATLVAVCAFAAYGAFLFMMSLYLQSERGYSAMFTGL MAB_0945|M.abscessus_ATCC_1997 FIDLRFFRSIPFASATLTAICACMAWSAFLFTMSLYLQGQRHFSAMHTGL MAV_1387|M.avium_104 LIPLVIFSDRDFSLCNIGVAIISFAATAMMLPLTFYAQAVCGLSPTRSAL TH_3965|M.thermoresistible__bu LVPLQIFADRNFMLANVGVATIGFVVTAMVLPAMFFAQAVCGLSPTGSAL Mb2361c|M.bovis_AF2122/97 MMDLTLFRDTSYALAIATICTVFFAVYGMLLLTTQFLQNVRGYTPSVTGL Rv2333c|M.tuberculosis_H37Rv MMDLTLFRDTSYALAIATICTVFFAVYGMLLLTTQFLQNVRGYTPSVTGL MMAR_3642|M.marinum_M MMDLTLFRDSSYALSIGTICTVFFAVYGMLLLTTQFLQNVRGYTPGATGL MUL_0911|M.ulcerans_Agy99 MLDVSVFANRRFSGGSLAVTAGFLTLFGFIFVITQYFQFIKDYTALQTGV MLBr_01562|M.leprae_Br4923 VVPFDLFRDRNRLVTFIAIFLAGGVIFSLTVSIGLYIQDILGYSALRAGI .: . .* . . .: . : * :. :.: Mflv_1730|M.gilvum_PYR-GCK IYLPIALGALFCSPLSGRLVGRYGARPSLVAAG-ILITTAATLLTLLTAT Mvan_5021|M.vanbaalenii_PYR-1 IYLPIAIGALLFSPLSGRLVGRYGARPSLVIAG-VTITAAATMLTFLTAT MSMEG_5670|M.smegmatis_MC2_155 IYLPIAIGALIFSPLSGRMVGRFGSRPSLVSAG-VLITAATVMLAQMTAT MAB_0945|M.abscessus_ATCC_1997 IYLPIAVGALVFSPISGRMVGRFGARPSLLAAG-TLFLTASLLLTRVSEA MAV_1387|M.avium_104 LIAPMAIANGVFAPFVGKIVDRYHPRPVLGFGFSLLAIALTWLTFEMSPA TH_3965|M.thermoresistible__bu LIAPMAVASGVLAPMAGRIVDRSHPTPVVGFGFSVVAVGLTWLAVEMAPT Mb2361c|M.bovis_AF2122/97 MILPFSAAVAIVSPLVGHLVGRIGARVPILAGLCMLMLGLLMLIFSEHRS Rv2333c|M.tuberculosis_H37Rv MILPFSAAVAIVSPLVGHLVGRIGARVPILAGLCMLMLGLLMLIFSEHRS MMAR_3642|M.marinum_M MILPFSAGVAVVSPLVGSLVARVGARVLILIGLGLLMLGLLTLIASEHRS MUL_0911|M.ulcerans_Agy99 RLLPVAFSIALAAILGPRLVERVGTTAVVAAGLAVFAAALAWAS-TADAT MLBr_01562|M.leprae_Br4923 GFIPFVIAMGIGLGVSSQLVSRFSPRVLTIGGGWLLMVAMLYGWAFMNRG *. . . . :* * . . Mflv_1730|M.gilvum_PYR-GCK TPVWH-LLIVFAVFGVGFSMVNAPITNAAVSGMPLDRAGAASAVTSTSRQ Mvan_5021|M.vanbaalenii_PYR-1 TPVWS-LLMVFAVFGIGFSMVNAPVTNAAVSGMPLDRAGAASAVTSTSRQ MSMEG_5670|M.smegmatis_MC2_155 TPVWL-LLVIFAVFGIGFALVNAPITTAAVSGMPLDRAGAASAVASTSRQ MAB_0945|M.abscessus_ATCC_1997 TPIWE-LLVTFAIFGAGFAMVNAPITNAAVSGMPLDRAGAASAVTSTSRQ MAV_1387|M.avium_104 TPIWR-LVLPFFAMGVGMAFVWSPLTATATRNLSAQLAGAGSAVYNSVRQ TH_3965|M.thermoresistible__bu TPIWR-LVLPFVAVGVGMAFIWSPLATTATRQLPLHLSGAGSGVYNTTRQ Mb2361c|M.bovis_AF2122/97 SALVL-VGLGLCGS--GVALCLTPITTVAMTAVPAERAGMASGIMSAQRA Rv2333c|M.tuberculosis_H37Rv SALVL-VGLGLCGS--GVALCLTPITTVAMTAVPAERAGMASGIMSAQRA MMAR_3642|M.marinum_M WALVL-VGLGFCGT--GVALCLTPITTVAMTAVPPERAGMASGIMSAQRA MUL_0911|M.ulcerans_Agy99 TPYTQ-ITLQMLLLGGGLGLTTAPATEAIMGSLPADRAGVGSAVNDTTRE MLBr_01562|M.leprae_Br4923 VPYFPNLLAPIVVGGIGIGMAVVPLTLSAIAGVGFDRIGPVSAIALMLQS . : : *..: * : : . * *.: : Mflv_1730|M.gilvum_PYR-GCK VGVSIGVALCGSVAGA------AMAGSGTDFATAARPLWFVCIALGLVIL Mvan_5021|M.vanbaalenii_PYR-1 VGVSIGVALCGSLAGS------AMATGGADFAAAARPLWFVCMALGLVIL MSMEG_5670|M.smegmatis_MC2_155 VGVSIGVALCGSVAGT------ALAGTGVDFAAASRPLWLICTALGVVIV MAB_0945|M.abscessus_ATCC_1997 VGVSIGVALCGSIG--------------------TPALWFMCAGLGLLIA MAV_1387|M.avium_104 LGAVLGSAGMAAFMTW------RIGAEMP-GQPGGGGEDSAGPVLPEFLR TH_3965|M.thermoresistible__bu IGSVLGSAGMAAFLTG------RLSAELP-FGATAVPAGEQTRVLPEFLH Mb2361c|M.bovis_AF2122/97 IGSTIGFAVLGSVLAA------WLSATLEPHLERAVPDPVQRHVLAEIII Rv2333c|M.tuberculosis_H37Rv IGSTIGFAVLGSVLAA------WLSATLEPHLERAVPDPVQRHVLAEIII MMAR_3642|M.marinum_M IGSTIGFAVLGSVLAA------WLSATLEPHLEPAVPDPVQRHTIAEVII MUL_0911|M.ulcerans_Agy99 LGGTLGVAIAGSVFAS------VYSGQLGSASALATLPSDVRSAMKGSMA MLBr_01562|M.leprae_Br4923 LGGPLVLAVIQAVITSRTLYLGGTTGPVKFMNDAQLRALDHGYTYGLLWV :* : * :. Mflv_1730|M.gilvum_PYR-GCK AVGFFSTSQRAVRSAERLAPLVAGAPDPVNGAHVR--------------- Mvan_5021|M.vanbaalenii_PYR-1 GLGLFATSQRALRSAERLAPLVSGAPEPVGGAHVR--------------- MSMEG_5670|M.smegmatis_MC2_155 AIGIVSTSPWALRSAERLAPLIGQHHRPAEVAHAR--------------- MAB_0945|M.abscessus_ATCC_1997 TLGIVSTSPAAVRSAQRLAPLIEGT-TAREMSRVG--------------- MAV_1387|M.avium_104 GPFAAAMSQSVLLPAFIALFGIVAALFLVGFRPWAHRDGGTDAFGPDDYG TH_3965|M.thermoresistible__bu APYAAAMAQSMLLPAFVALFGVLAAIFLAGIVLSTPQP---------DAD Mb2361c|M.bovis_AF2122/97 DSANPRAHVGGIVPRRHIEHRDPVAIAEEDFIEG---------------- Rv2333c|M.tuberculosis_H37Rv DSANPRAHVGGIVPRRHIEHRDPVAIAEEDFIEG---------------- MMAR_3642|M.marinum_M DSANPRAHVGGIVPRREIVHRDPVAIAEEDFIEG---------------- MUL_0911|M.ulcerans_Agy99 VAHKVIDQLPAGPAAGVRDAVNHAFLDGLQVATLVCAG------------ MLBr_01562|M.leprae_Br4923 AGAVVIVGVAALFIGYTPEQVAYAQEVKEAVDAGEL-------------- Mflv_1730|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_5021|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_5670|M.smegmatis_MC2_155 -------------------------------------------------- MAB_0945|M.abscessus_ATCC_1997 -------------------------------------------------- MAV_1387|M.avium_104 GDYHDDYDDDDAYVELILVREPEPEAQQRAGQPRRPQPTPAPPADVRRRD TH_3965|M.thermoresistible__bu AQYLDEHDD---YLVIELAR-----------------PDPNPRTDIAVTA Mb2361c|M.bovis_AF2122/97 -------------------------------------------IRVALLV Rv2333c|M.tuberculosis_H37Rv -------------------------------------------IRVALLV MMAR_3642|M.marinum_M -------------------------------------------IRVAFFI MUL_0911|M.ulcerans_Agy99 ---------------------------------------------IALAA MLBr_01562|M.leprae_Br4923 -------------------------------------------------- Mflv_1730|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_5021|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_5670|M.smegmatis_MC2_155 -------------------------------------------------- MAB_0945|M.abscessus_ATCC_1997 -------------------------------------------------- MAV_1387|M.avium_104 PVESRRSVLDERPAQVQPIGFAHNGSHVDGGKRLRQVAVRRAPKPGPPAD TH_3965|M.thermoresistible__bu VIPALRPTLRP--------------------------TLR--PSLGPPGG Mb2361c|M.bovis_AF2122/97 ATATLAVVFLAG--------------------------WRWFPRDVQTAG Rv2333c|M.tuberculosis_H37Rv ATATLAVVFLAG--------------------------WRWFPRDVHTAG MMAR_3642|M.marinum_M ATASLGFVFLAG--------------------------WRWFPRGGAGML MUL_0911|M.ulcerans_Agy99 AIVVG---------------------------------WLLPARAGQPTP MLBr_01562|M.leprae_Br4923 -------------------------------------------------- Mflv_1730|M.gilvum_PYR-GCK ----------------------------------------------- Mvan_5021|M.vanbaalenii_PYR-1 ----------------------------------------------- MSMEG_5670|M.smegmatis_MC2_155 ----------------------------------------------- MAB_0945|M.abscessus_ATCC_1997 ----------------------------------------------- MAV_1387|M.avium_104 RFTRPPRRHHPGPAGHHLGEGESLRGQHHRPDPDDDPTGYGRHSSGN TH_3965|M.thermoresistible__bu PVVQP-------------NNTAALR---------------------- Mb2361c|M.bovis_AF2122/97 SDAKR--EAAYSDDRRVRG---------------------------- Rv2333c|M.tuberculosis_H37Rv SDLSERLPTAMTVECAVSHMPGATWCRLWPA---------------- MMAR_3642|M.marinum_M GDAER--------EADAVGL--------------------------- MUL_0911|M.ulcerans_Agy99 AQTEPALAQV------------------------------------- MLBr_01562|M.leprae_Br4923 -----------------------------------------------