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NETVGALSARRKAIILVSCCLSLLIVSMDATIVNVAIPSIRSDLGASPSQLQWVIDVYTLVLASLLLLAG ATGDRFGRRRTFHLGLTVFAVASLLCSVAPNIETLIAARLLQAIGGSMLNPVAMSIITQVFTGRVERARA IGVWGSVVGISMALGPLVGGALIEYVDWRAVFWINLPICALAILLTAIFVRESKSSTMRDVDPVGQGLGV AFLFGVVFVLIEGPGMGWTDPRTLAVAATALVAFLAFLRYESRRHDPFIDLRFFRSVPFASATLVAVCAF AAYGAFLFMMSLYLQSERGYSAMFTGLIYLPIAIGALIFSPLSGRMVGRFGSRPSLVSAGVLITAATVML AQMTATTPVWLLLVIFAVFGIGFALVNAPITTAAVSGMPLDRAGAASAVASTSRQVGVSIGVALCGSVAG TALAGTGVDFAAASRPLWLICTALGVVIVAIGIVSTSPWALRSAERLAPLIGQHHRPAEVAHAR*
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. smegmatis MC2 155 | MSMEG_5670 | - | - | 100% (485) | efflux membrane protein |
M. smegmatis MC2 155 | MSMEG_3405 | - | 7e-62 | 33.73% (415) | methylenomycin A resistance protein |
M. smegmatis MC2 155 | MSMEG_1427 | - | 3e-59 | 32.30% (421) | transmembrane efflux protein |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb2361c | - | 1e-74 | 35.56% (419) | integral membrane transport protein |
M. gilvum PYR-GCK | Mflv_1730 | - | 0.0 | 74.48% (478) | EmrB/QacA family drug resistance transporter |
M. tuberculosis H37Rv | Rv2333c | - | 5e-74 | 35.56% (419) | integral membrane transport protein |
M. leprae Br4923 | MLBr_01562 | - | 1e-53 | 32.67% (401) | putative transmembrane efflux protein |
M. abscessus ATCC 19977 | MAB_0945 | - | 0.0 | 70.34% (472) | EmrB/QacA family drug resistance transporter |
M. marinum M | MMAR_1146 | - | 8e-80 | 35.73% (445) | integral membrane transport protein |
M. avium 104 | MAV_1387 | - | 1e-56 | 31.84% (468) | drug transporter |
M. thermoresistible (build 8) | TH_2682 | - | 4e-60 | 32.85% (417) | PUTATIVE transmembrane efflux protein |
M. ulcerans Agy99 | MUL_0911 | - | 2e-80 | 35.57% (447) | integral membrane transport protein |
M. vanbaalenii PYR-1 | Mvan_5021 | - | 0.0 | 73.43% (478) | EmrB/QacA family drug resistance transporter |
CLUSTAL 2.0.9 multiple sequence alignment Mflv_1730|M.gilvum_PYR-GCK -------------------------------------------------M Mvan_5021|M.vanbaalenii_PYR-1 -------------------------------------------------M MSMEG_5670|M.smegmatis_MC2_155 ------------------------------------------MNETVGAL MAB_0945|M.abscessus_ATCC_1997 ------------------------------------------MEAAVGAL Mb2361c|M.bovis_AF2122/97 -------------------------------------------------- Rv2333c|M.tuberculosis_H37Rv -------------------------------------------------- MMAR_1146|M.marinum_M --------------------------------------------MRIQPV MUL_0911|M.ulcerans_Agy99 --------------------------------------------MRIQPV TH_2682|M.thermoresistible__bu -------------------------------MVDALSQPGQDIGASVAAL MAV_1387|M.avium_104 -------------------------------------------------- MLBr_01562|M.leprae_Br4923 MVTLYDHERAVHNWTAARSDRPAPSRLTQQVEPASERTSKYPTLLPSGRF Mflv_1730|M.gilvum_PYR-GCK TPRRKAIILVSCCLSLLIVSMDATIVNVAIPSIRADLSASPAQMQWVVDI Mvan_5021|M.vanbaalenii_PYR-1 TPRRKAIILVSCCLSLLIVSMDATIVNVAIPSIRDDLSATPAQMQWVVDV MSMEG_5670|M.smegmatis_MC2_155 SARRKAIILVSCCLSLLIVSMDATIVNVAIPSIRSDLGASPSQLQWVIDV MAB_0945|M.abscessus_ATCC_1997 SERRKIVILGSCCLSLLIVSMDSTIVNVALPTIRADFGATTSQLQWVIDI Mb2361c|M.bovis_AF2122/97 MNRTQLLTLIATGLGLFMIFLDALIVNVALPDIQRSFAVGEDGLQWVVAS Rv2333c|M.tuberculosis_H37Rv MNRTQLLTLIATGLGLFMIFLDALIVNVALPDIQRSFAVGEDGLQWVVAS MMAR_1146|M.marinum_M FRDHPIPALAVICLSVFVISVDATIVNVALPTLSRQLGADTAQLQWIVDA MUL_0911|M.ulcerans_Agy99 FRDHPILALAVICLSVFVISVDATIVNVALPTLSRELGADTAQLQWIVDA TH_2682|M.thermoresistible__bu STRARVWLLTVACMGVALVISSMVALNAALPDIAVETAATQSQLTWVVDG MAV_1387|M.avium_104 -----------MMIGFFMIMVDSTIVAIANPTIMADLHIGYDTVVWVTSA MLBr_01562|M.leprae_Br4923 PSGRFIAAVIVIGGMQLLATMDSTVAIVALPKIQNELSLSDAGRSWGITA : . * * : . * Mflv_1730|M.gilvum_PYR-GCK YTLVLASLLMLSGATGDRFGRRRLFQIGLTVFALGSLACSLAPTIDTLIG Mvan_5021|M.vanbaalenii_PYR-1 YTLVLASLLMLSGATGDRFGRRRVFQIGLAVFALGSLACSLAPTIDALIG MSMEG_5670|M.smegmatis_MC2_155 YTLVLASLLLLAGATGDRFGRRRTFHLGLTVFAVASLLCSVAPNIETLIA MAB_0945|M.abscessus_ATCC_1997 YTLGLASLLMLSGAAGDRLGRRKVFHLGLSIFAIGSLLCSVAPTVGLLIA Mb2361c|M.bovis_AF2122/97 YSLGMAVFIMSAATLADLYGRRRWYLIGVSLFTLGSIACGLAPSIAVLTT Rv2333c|M.tuberculosis_H37Rv YSLGMAVFIMSAATLADLDGRRRWYLIGVSLFTLGSIACGLAPSIAVLTT MMAR_1146|M.marinum_M YTLVMSGLLLSAGSLSDRYGRRGWLSAGLILFALTSALAAQVNSADTLIA MUL_0911|M.ulcerans_Agy99 YTLVMSGLLLSAGSLSDRYGRRGWLSAGLILFALTSALAAQVNSADTLVA TH_2682|M.thermoresistible__bu YTLVLACLLLPAGAIGDRYGRRGAMLVGLGLFTVASAAPLVLDGPLTLIL MAV_1387|M.avium_104 YLLGYAVVLLVAGRLGDRFGTKNLYLIGLAVFTVASVWCGLAGSAAMLIA MLBr_01562|M.leprae_Br4923 YVLTFGGLMLLGGRLGDTIGRKRTFIVGVALFTISSVLCAVAWDEVTLVI * * . .:: .. .* * : *: :*:: * * Mflv_1730|M.gilvum_PYR-GCK ARFLQGVGGSMLNPVALSIISQIFTKPVERARALGIWGGVTGISMAAGPI Mvan_5021|M.vanbaalenii_PYR-1 ARLLQGIGGSMLNPVALSIISQIFTQPVERARALGIWGGVTGISMAAGPI MSMEG_5670|M.smegmatis_MC2_155 ARLLQAIGGSMLNPVAMSIITQVFTGRVERARAIGVWGSVVGISMALGPL MAB_0945|M.abscessus_ATCC_1997 ARLLQAVGGSMLNPVALSIISQVFTGRVERARALGFWGAVVGISMALGPI Mb2361c|M.bovis_AF2122/97 ARGAQGLGAAAVSVTSLALVSAAFPEAKEKARAIGIWTAIASIGTTTGPT Rv2333c|M.tuberculosis_H37Rv ARGAQGLGAAAVSVTSLALVSAAFPEAKEKARAIGIWTAIASIGTTTGPT MMAR_1146|M.marinum_M ARAAMGVGAAVIFPTTLGLITNIFTDPVPRAKAIGLWTAMVGVGVAVGPI MUL_0911|M.ulcerans_Agy99 ARAAMGVGAAVIFPTTLGLITNIFTDPVPRAKAIGLWTAMVGVGVAVGPI TH_2682|M.thermoresistible__bu SRMVAGVGAAFVMPATLSLLTAAYPR-AQRNKAVGIWAAVAGSGAVVGFL MAV_1387|M.avium_104 ARVVQGVGAGVMTPQTLSTITRIFPA-ERRGVAVSVWSATAGAASLAGPL MLBr_01562|M.leprae_Br4923 ARLLQGIGSAIASPTGLALVATTFSKGSARNTATAVFAAMTAIGSVMGLV :* .:*.. :. :: :. : * ..: . .. . * Mflv_1730|M.gilvum_PYR-GCK VGGLLIETVGWRSVFWINLPICAAAIILTAVFVPESKSQTMRNVDPIGQG Mvan_5021|M.vanbaalenii_PYR-1 VGGLLIDTIGWRSVFWINLPICAAAILLTAIFVPESKSQTMRNVDPIGQG MSMEG_5670|M.smegmatis_MC2_155 VGGALIEYVDWRAVFWINLPICALAILLTAIFVRESKSSTMRDVDPVGQG MAB_0945|M.abscessus_ATCC_1997 VGGLLIQWVGWRAVFWINLPVCVLAFVLTAVFVPETKSATMRDIDPVGQA Mb2361c|M.bovis_AF2122/97 LGGLLVDQWGWRSIFYVNLPMGALVLFLTLCYVEESCNERARRFDLSGQL Rv2333c|M.tuberculosis_H37Rv LGGLLVDQWGWRSIFYVNLPMGALVLFLTLCYVEESCNERARRFDLSGQL MMAR_1146|M.marinum_M TGGWLLEHFSWGSIFLVNVPIAVAAMAGAILFVPTSRDPAAPRVDVPGLM MUL_0911|M.ulcerans_Agy99 TGGWLLEHFSWGSIFLVNVPIAVAAMAGAILFVPTSRDPAAPRVDVPGLM TH_2682|M.thermoresistible__bu GTGVLLHFWSWPSIFWA-FTVSGAGLFVLACTVASSRDHRATPLDWPGAV MAV_1387|M.avium_104 AGGVLVDGLGWQWIFFVNVPIGVLGLVLAYWLVPVLPTQSHR-FDLVGVG MLBr_01562|M.leprae_Br4923 VGGALTEVS-WRLAFLVNVPIGLVMIYLARTALHETHKERMK-LDAAGAI * * . * * ..: : : .* * Mflv_1730|M.gilvum_PYR-GCK LGILFLFGTVFTLIEGPVLGWTNPRVLAIAAVAVVALIAFLRFESRRHDP Mvan_5021|M.vanbaalenii_PYR-1 LAIMFLFGTVFTLIEGPVLGWTNPRVVVAAVVVALALVAFLRFESRRHDP MSMEG_5670|M.smegmatis_MC2_155 LGVAFLFGVVFVLIEGPGMGWTDPRTLAVAATALVAFLAFLRYESRRHDP MAB_0945|M.abscessus_ATCC_1997 LAVLFLFGIVFALIEGPSLGWATPGLIVVLAVALAAFAVFLRYESRRRHP Mb2361c|M.bovis_AF2122/97 LFIVAVGALVYAVIEGPQIGWTSVQTIVMLWTAAVGCALFVWLERRSSNP Rv2333c|M.tuberculosis_H37Rv LFIVAVGALVYAVIEGPQIGWTSVQTIVMLWTAAVGCALFVWLERRSSNP MMAR_1146|M.marinum_M LSAVGITALVYTIIEAPNWGWTSTRASGGFIAAAIVLVGFALWERRSSHP MUL_0911|M.ulcerans_Agy99 LSAVGITALVYTIIEAPNWGWTSTRASGGFIAAAIVLVGFALWERRSSHP TH_2682|M.thermoresistible__bu LIGGAVAVFVYGVLEAPVHGWTHPVVYGSMAAGVALALAFAVVELRSAHP MAV_1387|M.avium_104 LSGVGMLLIVFGLQQGQAAHWQPWIWALIVAGVGFVTVFVFWQSVNVREP MLBr_01562|M.leprae_Br4923 LATLACTAAVFAFSMGPEKGWISLTTIGSGLVALVAAIAFAVVERTAENP * *: . . * . . .* Mflv_1730|M.gilvum_PYR-GCK FLDLRFFRSIPFTTATINAISAFAAWGAFLFMMSLYLQGERGFSAMQTGL Mvan_5021|M.vanbaalenii_PYR-1 FLDLRFFRSIPFTTATVIAISAFAAWGAFLFLMSLYLQGERGFSAMHTGL MSMEG_5670|M.smegmatis_MC2_155 FIDLRFFRSVPFASATLVAVCAFAAYGAFLFMMSLYLQSERGYSAMFTGL MAB_0945|M.abscessus_ATCC_1997 FIDLRFFRSIPFASATLTAICACMAWSAFLFTMSLYLQGQRHFSAMHTGL Mb2361c|M.bovis_AF2122/97 MMDLTLFRDTSYALAIATICTVFFAVYGMLLLTTQFLQNVRGYTPSVTGL Rv2333c|M.tuberculosis_H37Rv MMDLTLFRDTSYALAIATICTVFFAVYGMLLLTTQFLQNVRGYTPSVTGL MMAR_1146|M.marinum_M MLDVSVFANRRFSGGSLAVTAGFLTLFGFIFVITQYFQFIKDYTALQTGV MUL_0911|M.ulcerans_Agy99 MLDVSVFANRRFSGGSLAVTAGFLTLFGFIFVITQYFQFIKDYTALQTGV TH_2682|M.thermoresistible__bu LLDIRLFAKPDFTTGAVGVTFFFLANFGFFFVSMQYMQLMLGYSALQTAF MAV_1387|M.avium_104 LIPLVIFSDRDFSLCNIGVAIISFAATAMMLPLTFYAQAVCGLSPTRSAL MLBr_01562|M.leprae_Br4923 VVPFDLFRDRNRLVTFIAIFLAGGVIFSLTVSIGLYIQDILGYSALRAGI .: . .* . . .: . : * :. :.. Mflv_1730|M.gilvum_PYR-GCK IYLPIALGALFCSPLSGRLVGRYGARPSLVAAGILITTAATLLTLLT-AT Mvan_5021|M.vanbaalenii_PYR-1 IYLPIAIGALLFSPLSGRLVGRYGARPSLVIAGVTITAAATMLTFLT-AT MSMEG_5670|M.smegmatis_MC2_155 IYLPIAIGALIFSPLSGRMVGRFGSRPSLVSAGVLITAATVMLAQMT-AT MAB_0945|M.abscessus_ATCC_1997 IYLPIAVGALVFSPISGRMVGRFGARPSLLAAGTLFLTASLLLTRVS-EA Mb2361c|M.bovis_AF2122/97 MILPFSAAVAIVSPLVGHLVGRIGARVPILAGLCMLMLGLLMLIFSE-HR Rv2333c|M.tuberculosis_H37Rv MILPFSAAVAIVSPLVGHLVGRIGARVPILAGLCMLMLGLLMLIFSE-HR MMAR_1146|M.marinum_M RLLPVALSIALAAILGPRLVERVGTTAVVAAGLAVFAAALAWASTAD-AT MUL_0911|M.ulcerans_Agy99 RLLPVAFSIALAAILGPRLVERVGTTAVVAAGLAVFAAALAWASTAD-AT TH_2682|M.thermoresistible__bu ALTPLTIPLLLLSVTTQWYLPRLGLRAVISTGLLLIAAGLFYARTLE-IA MAV_1387|M.avium_104 LIAPMAIANGVFAPFVGKIVDRYHPRPVLGFGFSLLAIALTWLTFEMSPA MLBr_01562|M.leprae_Br4923 GFIPFVIAMGIGLGVSSQLVSRFSPRVLTIGGGWLLMVAMLYGWAFMNRG *. . : * . : . Mflv_1730|M.gilvum_PYR-GCK TPVWHLLIVFAVFG-VGFSMVNAPITNAAVSGMPLDRAGAASAVTSTSRQ Mvan_5021|M.vanbaalenii_PYR-1 TPVWSLLMVFAVFG-IGFSMVNAPVTNAAVSGMPLDRAGAASAVTSTSRQ MSMEG_5670|M.smegmatis_MC2_155 TPVWLLLVIFAVFG-IGFALVNAPITTAAVSGMPLDRAGAASAVASTSRQ MAB_0945|M.abscessus_ATCC_1997 TPIWELLVTFAIFG-AGFAMVNAPITNAAVSGMPLDRAGAASAVTSTSRQ Mb2361c|M.bovis_AF2122/97 S-SALVLVGLGLCG-SGVALCLTPITTVAMTAVPAERAGMASGIMSAQRA Rv2333c|M.tuberculosis_H37Rv S-SALVLVGLGLCG-SGVALCLTPITTVAMTAVPAERAGMASGIMSAQRA MMAR_1146|M.marinum_M TPYTQIALQMLLLG-GGLGLTTAPATEAIMGSLPADRAGVGSAVNDTTRE MUL_0911|M.ulcerans_Agy99 TPYTQITLQMLLLG-GGLGLTTAPATEAIMGSLPADRAGVGSAVNDTTRE TH_2682|M.thermoresistible__bu SPYLDLAVPLLIMS-TGIGLCTAPSTSAIMGAVPDEKHGVASAVNDTTRE MAV_1387|M.avium_104 TPIWRLVLPFFAMG-VGMAFVWSPLTATATRNLSAQLAGAGSAVYNSVRQ MLBr_01562|M.leprae_Br4923 VPYFPNLLAPIVVGGIGIGMAVVPLTLSAIAGVGFDRIGPVSAIALMLQS : . *..: * * : : * *.: : Mflv_1730|M.gilvum_PYR-GCK VGVSIG------------------------VALCGSVAGAAMAGSGTDFA Mvan_5021|M.vanbaalenii_PYR-1 VGVSIG------------------------VALCGSLAGSAMATGGADFA MSMEG_5670|M.smegmatis_MC2_155 VGVSIG------------------------VALCGSVAGTALAGTGVDFA MAB_0945|M.abscessus_ATCC_1997 VGVSIG------------------------VALCGSIG------------ Mb2361c|M.bovis_AF2122/97 IGSTIG------------------------FAVLGSVLAAWLSATLEPHL Rv2333c|M.tuberculosis_H37Rv IGSTIG------------------------FAVLGSVLAAWLSATLEPHL MMAR_1146|M.marinum_M LGGTLG------------------------VAIAGSVFASVYSGQLGSAS MUL_0911|M.ulcerans_Agy99 LGGTLG------------------------VAIAGSVFASVYSGQLGSAS TH_2682|M.thermoresistible__bu IGAALG------------------------IAVAGSVLAAEYGDRLR--P MAV_1387|M.avium_104 LGAVLGSAGMAAFMTWRIGAEMPGQPGGGGEDSAGPVLPEFLRGPFAAAM MLBr_01562|M.leprae_Br4923 LGGPLV------------------------LAVIQAVITSRTLYLGGTTG :* : .: Mflv_1730|M.gilvum_PYR-GCK TAARPLWFVCIALGLVILAVGFFSTSQRAVRSAER--------------- Mvan_5021|M.vanbaalenii_PYR-1 AAARPLWFVCMALGLVILGLGLFATSQRALRSAER--------------- MSMEG_5670|M.smegmatis_MC2_155 AASRPLWLICTALGVVIVAIGIVSTSPWALRSAER--------------- MAB_0945|M.abscessus_ATCC_1997 --TPALWFMCAGLGLLIATLGIVSTSPAAVRSAQR--------------- Mb2361c|M.bovis_AF2122/97 ERAVPDPVQRHVLAEIIIDSANPRAHVGGIVPRRHIEHRDPVAIAEEDFI Rv2333c|M.tuberculosis_H37Rv ERAVPDPVQRHVLAEIIIDSANPRAHVGGIVPRRHIEHRDPVAIAEEDFI MMAR_1146|M.marinum_M TLATLPSDVRSAMKGSMAVAHKVIDQLPAGPAAGVRDAVN------HAFL MUL_0911|M.ulcerans_Agy99 ALATLPSDVRSAMKGSMAVAHKVIDQLPAGPAAGVRDAVN------HAFL TH_2682|M.thermoresistible__bu HLGALPEPVRQAASNSLAEALEAARQLGP-QGARLAEFAQ------SAFL MAV_1387|M.avium_104 SQSVLLPAFIALFGIVAALFLVGFRPWAHRDGGTDAFGPDDYGGDYHDDY MLBr_01562|M.leprae_Br4923 PVKFMNDAQLRALDHGYTYGLLWVAGAVVIVGVAALFIG----------- Mflv_1730|M.gilvum_PYR-GCK ----LAPLVAGAPDPVNGAHVR---------------------------- Mvan_5021|M.vanbaalenii_PYR-1 ----LAPLVSGAPEPVGGAHVR---------------------------- MSMEG_5670|M.smegmatis_MC2_155 ----LAPLIGQHHRPAEVAHAR---------------------------- MAB_0945|M.abscessus_ATCC_1997 ----LAPLIEGT-TAREMSRVG---------------------------- Mb2361c|M.bovis_AF2122/97 EGIRVALLVATATLAVVFLAGWRWFPRDVQT----------------AGS Rv2333c|M.tuberculosis_H37Rv EGIRVALLVATATLAVVFLAGWRWFPRDVHT----------------AGS MMAR_1146|M.marinum_M DGLQVATLVCAGIALAAAIVVGWLLPAR-------------------AGQ MUL_0911|M.ulcerans_Agy99 DGLQVATLVCAGIALAAAIVVGWLLPAR-------------------AGQ TH_2682|M.thermoresistible__bu EAMHVSLIVLGALCALAAAFVAVWAPGRDGRQYGFVERWTSRWSGEEAGG MAV_1387|M.avium_104 DDDDAYVELILVREPEPEAQQRAGQPRRPQPTPAPPADVRRRDPVESRRS MLBr_01562|M.leprae_Br4923 ---YTPEQVAYAQEVKEAVDAGEL-------------------------- : Mflv_1730|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_5021|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_5670|M.smegmatis_MC2_155 -------------------------------------------------- MAB_0945|M.abscessus_ATCC_1997 -------------------------------------------------- Mb2361c|M.bovis_AF2122/97 DAKR--EAAYSDDRRVRG-------------------------------- Rv2333c|M.tuberculosis_H37Rv DLSERLPTAMTVECAVSHMPGATWCRLWPA-------------------- MMAR_1146|M.marinum_M PTPAQTEPALAQA------------------------------------- MUL_0911|M.ulcerans_Agy99 PTPAQTEPALAQV------------------------------------- TH_2682|M.thermoresistible__bu AVAEHDDGGVRAATGDGWEHGTVDDP------------------------ MAV_1387|M.avium_104 VLDERPAQVQPIGFAHNGSHVDGGKRLRQVAVRRAPKPGPPADRFTRPPR MLBr_01562|M.leprae_Br4923 -------------------------------------------------- Mflv_1730|M.gilvum_PYR-GCK ---------------------------------------- Mvan_5021|M.vanbaalenii_PYR-1 ---------------------------------------- MSMEG_5670|M.smegmatis_MC2_155 ---------------------------------------- MAB_0945|M.abscessus_ATCC_1997 ---------------------------------------- Mb2361c|M.bovis_AF2122/97 ---------------------------------------- Rv2333c|M.tuberculosis_H37Rv ---------------------------------------- MMAR_1146|M.marinum_M ---------------------------------------- MUL_0911|M.ulcerans_Agy99 ---------------------------------------- TH_2682|M.thermoresistible__bu ---------------------------------------- MAV_1387|M.avium_104 RHHPGPAGHHLGEGESLRGQHHRPDPDDDPTGYGRHSSGN MLBr_01562|M.leprae_Br4923 ----------------------------------------