For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
NRTQLLTLIATGLGLFMIFLDALIVNVALPDIQRSFAVGEDGLQWVVASYSLGMAVFIMSAATLADLDGR RRWYLIGVSLFTLGSIACGLAPSIAVLTTARGAQGLGAAAVSVTSLALVSAAFPEAKEKARAIGIWTAIA SIGTTTGPTLGGLLVDQWGWRSIFYVNLPMGALVLFLTLCYVEESCNERARRFDLSGQLLFIVAVGALVY AVIEGPQIGWTSVQTIVMLWTAAVGCALFVWLERRSSNPMMDLTLFRDTSYALAIATICTVFFAVYGMLL LTTQFLQNVRGYTPSVTGLMILPFSAAVAIVSPLVGHLVGRIGARVPILAGLCMLMLGLLMLIFSEHRSS ALVLVGLGLCGSGVALCLTPITTVAMTAVPAERAGMASGIMSAQRAIGSTIGFAVLGSVLAAWLSATLEP HLERAVPDPVQRHVLAEIIIDSANPRAHVGGIVPRRHIEHRDPVAIAEEDFIEGIRVALLVATATLAVVF LAGWRWFPRDVHTAGSDLSERLPTAMTVECAVSHMPGATWCRLWPA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv2333c | - | - | 100% (537) | PROBABLE CONSERVED INTEGRAL MEMBRANE TRANSPORT PROTEIN |
| M. tuberculosis H37Rv | Rv2459 | - | e-113 | 44.05% (504) | integral membrane transport protein |
| M. tuberculosis H37Rv | Rv3239c | - | 8e-58 | 34.59% (425) | transmembrane transport protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2361c | - | 0.0 | 99.61% (508) | integral membrane transport protein |
| M. gilvum PYR-GCK | Mflv_1730 | - | 2e-75 | 35.73% (417) | EmrB/QacA family drug resistance transporter |
| M. leprae Br4923 | MLBr_01562 | - | 2e-50 | 28.67% (422) | putative transmembrane efflux protein |
| M. abscessus ATCC 19977 | MAB_0945 | - | 1e-74 | 36.19% (409) | EmrB/QacA family drug resistance transporter |
| M. marinum M | MMAR_3642 | - | 0.0 | 83.60% (500) | integral membrane transport protein |
| M. avium 104 | MAV_1387 | - | 6e-55 | 31.95% (410) | drug transporter |
| M. smegmatis MC2 155 | MSMEG_5670 | - | 9e-74 | 35.56% (419) | efflux membrane protein |
| M. thermoresistible (build 8) | TH_2682 | - | 1e-63 | 33.87% (499) | PUTATIVE transmembrane efflux protein |
| M. ulcerans Agy99 | MUL_1468 | - | 1e-134 | 80.95% (294) | integral membrane transport protein |
| M. vanbaalenii PYR-1 | Mvan_5021 | - | 1e-74 | 35.94% (409) | EmrB/QacA family drug resistance transporter |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1730|M.gilvum_PYR-GCK -------------------------------------------------M
Mvan_5021|M.vanbaalenii_PYR-1 -------------------------------------------------M
MSMEG_5670|M.smegmatis_MC2_155 ------------------------------------------MNETVGAL
MAB_0945|M.abscessus_ATCC_1997 ------------------------------------------MEAAVGAL
Rv2333c|M.tuberculosis_H37Rv --------------------------------------------------
Mb2361c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_3642|M.marinum_M --------------------------------------------------
MUL_1468|M.ulcerans_Agy99 --------------------------------------------------
TH_2682|M.thermoresistible__bu -------------------------------MVDALSQPGQDIGASVAAL
MAV_1387|M.avium_104 --------------------------------------------------
MLBr_01562|M.leprae_Br4923 MVTLYDHERAVHNWTAARSDRPAPSRLTQQVEPASERTSKYPTLLPSGRF
Mflv_1730|M.gilvum_PYR-GCK TPRRKAIILVSCCLSLLIVSMDATIVNVAIPSIRADLSASPAQMQWVVDI
Mvan_5021|M.vanbaalenii_PYR-1 TPRRKAIILVSCCLSLLIVSMDATIVNVAIPSIRDDLSATPAQMQWVVDV
MSMEG_5670|M.smegmatis_MC2_155 SARRKAIILVSCCLSLLIVSMDATIVNVAIPSIRSDLGASPSQLQWVIDV
MAB_0945|M.abscessus_ATCC_1997 SERRKIVILGSCCLSLLIVSMDSTIVNVALPTIRADFGATTSQLQWVIDI
Rv2333c|M.tuberculosis_H37Rv MNRTQLLTLIATGLGLFMIFLDALIVNVALPDIQRSFAVGEDGLQWVVAS
Mb2361c|M.bovis_AF2122/97 MNRTQLLTLIATGLGLFMIFLDALIVNVALPDIQRSFAVGEDGLQWVVAS
MMAR_3642|M.marinum_M MNRTQLLTIFATGLGLFMIFLDAFIVNVALPDIQNTFGVGEDGLQWVVAA
MUL_1468|M.ulcerans_Agy99 MNRTQLLTIFATGLGLFMIFLDAFIVNVALPDIQNTFGVGEDGLQWVVAA
TH_2682|M.thermoresistible__bu STRARVWLLTVACMGVALVISSMVALNAALPDIAVETAATQSQLTWVVDG
MAV_1387|M.avium_104 -----------MMIGFFMIMVDSTIVAIANPTIMADLHIGYDTVVWVTSA
MLBr_01562|M.leprae_Br4923 PSGRFIAAVIVIGGMQLLATMDSTVAIVALPKIQNELSLSDAGRSWGITA
: . * * * *
Mflv_1730|M.gilvum_PYR-GCK YTLVLASLLMLSGATGDRFGRRRLFQIGLTVFALGSLACSLAPTIDTLIG
Mvan_5021|M.vanbaalenii_PYR-1 YTLVLASLLMLSGATGDRFGRRRVFQIGLAVFALGSLACSLAPTIDALIG
MSMEG_5670|M.smegmatis_MC2_155 YTLVLASLLLLAGATGDRFGRRRTFHLGLTVFAVASLLCSVAPNIETLIA
MAB_0945|M.abscessus_ATCC_1997 YTLGLASLLMLSGAAGDRLGRRKVFHLGLSIFAIGSLLCSVAPTVGLLIA
Rv2333c|M.tuberculosis_H37Rv YSLGMAVFIMSAATLADLDGRRRWYLIGVSLFTLGSIACGLAPSIAVLTT
Mb2361c|M.bovis_AF2122/97 YSLGMAVFIMSAATLADLYGRRRWYLIGVSLFTLGSIACGLAPSIAVLTT
MMAR_3642|M.marinum_M YSLGMAVFIMSAATLADRYGRRRWYLMGIALFTLGSIACGLAPSIAMLTA
MUL_1468|M.ulcerans_Agy99 YSLGMAVFIMSAATLADRYGRRRWYLMGIVLFTLGSIACGLAPSIAMLTA
TH_2682|M.thermoresistible__bu YTLVLACLLLPAGAIGDRYGRRGAMLVGLGLFTVASAAPLVLDGPLTLIL
MAV_1387|M.avium_104 YLLGYAVVLLVAGRLGDRFGTKNLYLIGLAVFTVASVWCGLAGSAAMLIA
MLBr_01562|M.leprae_Br4923 YVLTFGGLMLLGGRLGDTIGRKRTFIVGVALFTISSVLCAVAWDEVTLVI
* * . .:: .. .* * : :*: :*::.* : *
Mflv_1730|M.gilvum_PYR-GCK ARFLQGVGGSMLNPVALSIISQIFTKPVERARALGIWGGVTGISMAAGPI
Mvan_5021|M.vanbaalenii_PYR-1 ARLLQGIGGSMLNPVALSIISQIFTQPVERARALGIWGGVTGISMAAGPI
MSMEG_5670|M.smegmatis_MC2_155 ARLLQAIGGSMLNPVAMSIITQVFTGRVERARAIGVWGSVVGISMALGPL
MAB_0945|M.abscessus_ATCC_1997 ARLLQAVGGSMLNPVALSIISQVFTGRVERARALGFWGAVVGISMALGPI
Rv2333c|M.tuberculosis_H37Rv ARGAQGLGAAAVSVTSLALVSAAFPEAKEKARAIGIWTAIASIGTTTGPT
Mb2361c|M.bovis_AF2122/97 ARGAQGLGAAAVSVTSLALVSAAFPEAKEKARAIGIWTAIASIGTTTGPT
MMAR_3642|M.marinum_M ARGIQGFGAATVSVTSLALVSAAFPNPKEKARAIGIWTAVASVGTATGPT
MUL_1468|M.ulcerans_Agy99 ARGVQGFGAATVSVTSLALVSAAFPNPKEKARAIGIWTAVASVGTATGPT
TH_2682|M.thermoresistible__bu SRMVAGVGAAFVMPATLSLLTAAYPRAQ-RNKAVGIWAAVAGSGAVVGFL
MAV_1387|M.avium_104 ARVVQGVGAGVMTPQTLSTITRIFPAER-RGVAVSVWSATAGAASLAGPL
MLBr_01562|M.leprae_Br4923 ARLLQGIGSAIASPTGLALVATTFSKGSARNTATAVFAAMTAIGSVMGLV
:* ..*.. :: :: :. : * ..: . .. . *
Mflv_1730|M.gilvum_PYR-GCK VGGLLIETVGWRSVFWINLPICAAAIILTAVFVPESKSQTMRNVDPIGQG
Mvan_5021|M.vanbaalenii_PYR-1 VGGLLIDTIGWRSVFWINLPICAAAILLTAIFVPESKSQTMRNVDPIGQG
MSMEG_5670|M.smegmatis_MC2_155 VGGALIEYVDWRAVFWINLPICALAILLTAIFVRESKSSTMRDVDPVGQG
MAB_0945|M.abscessus_ATCC_1997 VGGLLIQWVGWRAVFWINLPVCVLAFVLTAVFVPETKSATMRDIDPVGQA
Rv2333c|M.tuberculosis_H37Rv LGGLLVDQWGWRSIFYVNLPMGALVLFLTLCYVEESCNERARRFDLSGQL
Mb2361c|M.bovis_AF2122/97 LGGLLVDQWGWRSIFYVNLPMGALVLFLTLCYVEESCNERARRFDLSGQL
MMAR_3642|M.marinum_M LGGLLVDTWGWRSIFYVNVPMGVFVILLTVGFVAESRNARAGRLDLSGQA
MUL_1468|M.ulcerans_Agy99 LGGLLVDTWGWRSIFYVNVPMGVFVILLTVGFVAESRNARAGQLDLSGQA
TH_2682|M.thermoresistible__bu GTGVLLHFWSWPSIFWAFTVSGAG-LFVLACTVASSRDHRATPLDWPGAV
MAV_1387|M.avium_104 AGGVLVDGLGWQWIFFVNVPIGVLGLVLAYWLVPVLPTQSHR-FDLVGVG
MLBr_01562|M.leprae_Br4923 VGGALTEVS-WRLAFLVNVPIGLVMIYLARTALHETHKERMK-LDAAGAI
* * . * * : : : .* *
Mflv_1730|M.gilvum_PYR-GCK LGILFLFGTVFTLIEGPVLGWTNPRVLAIAAVAVVALIAFLRFESRRHDP
Mvan_5021|M.vanbaalenii_PYR-1 LAIMFLFGTVFTLIEGPVLGWTNPRVVVAAVVVALALVAFLRFESRRHDP
MSMEG_5670|M.smegmatis_MC2_155 LGVAFLFGVVFVLIEGPGMGWTDPRTLAVAATALVAFLAFLRYESRRHDP
MAB_0945|M.abscessus_ATCC_1997 LAVLFLFGIVFALIEGPSLGWATPGLIVVLAVALAAFAVFLRYESRRRHP
Rv2333c|M.tuberculosis_H37Rv LFIVAVGALVYAVIEGPQIGWTSVQTIVMLWTAAVGCALFVWLERRSSNP
Mb2361c|M.bovis_AF2122/97 LFIVAVGALVYAVIEGPQIGWTSVQTIVMLWTAAVGCALFVWLERRSSNP
MMAR_3642|M.marinum_M LFIVTVGAFVYAVIEGPQIGWTSPLILTLLMTAAVGCALFLWLEGRSADP
MUL_1468|M.ulcerans_Agy99 LFIVTVGAFVYAVIEGPQIGWTSPLILTLLMTAIVGCALFLWLEGRSADP
TH_2682|M.thermoresistible__bu LIGGAVAVFVYGVLEAPVHGWTHPVVYGSMAAGVALALAFAVVELRSAHP
MAV_1387|M.avium_104 LSGVGMLLIVFGLQQGQAAHWQPWIWALIVAGVGFVTVFVFWQSVNVREP
MLBr_01562|M.leprae_Br4923 LATLACTAAVFAFSMGPEKGWISLTTIGSGLVALVAAIAFAVVERTAENP
* *: . . * . . .*
Mflv_1730|M.gilvum_PYR-GCK FLDLRFFRSIPFTTATINAISAFAAWGAFLFMMSLYLQGERGFSAMQTGL
Mvan_5021|M.vanbaalenii_PYR-1 FLDLRFFRSIPFTTATVIAISAFAAWGAFLFLMSLYLQGERGFSAMHTGL
MSMEG_5670|M.smegmatis_MC2_155 FIDLRFFRSVPFASATLVAVCAFAAYGAFLFMMSLYLQSERGYSAMFTGL
MAB_0945|M.abscessus_ATCC_1997 FIDLRFFRSIPFASATLTAICACMAWSAFLFTMSLYLQGQRHFSAMHTGL
Rv2333c|M.tuberculosis_H37Rv MMDLTLFRDTSYALAIATICTVFFAVYGMLLLTTQFLQNVRGYTPSVTGL
Mb2361c|M.bovis_AF2122/97 MMDLTLFRDTSYALAIATICTVFFAVYGMLLLTTQFLQNVRGYTPSVTGL
MMAR_3642|M.marinum_M MMDLTLFRDSSYALSIGTICTVFFAVYGMLLLTTQFLQNVRGYTPGATGL
MUL_1468|M.ulcerans_Agy99 MMDLTLFRDSSYALSIGTICTVFFAVYGMLLLTTQFLHNVRGYTQGSG--
TH_2682|M.thermoresistible__bu LLDIRLFAKPDFTTGAVGVTFFFLANFGFFFVSMQYMQLMLGYSALQTAF
MAV_1387|M.avium_104 LIPLVIFSDRDFSLCNIGVAIISFAATAMMLPLTFYAQAVCGLSPTRSAL
MLBr_01562|M.leprae_Br4923 VVPFDLFRDRNRLVTFIAIFLAGGVIFSLTVSIGLYIQDILGYSALRAGI
.: : :* . . .: . : : :
Mflv_1730|M.gilvum_PYR-GCK IYLPIALGALFCSPLSGRLVGRYGARPSLVAAGILITTAATLLTLLTA-T
Mvan_5021|M.vanbaalenii_PYR-1 IYLPIAIGALLFSPLSGRLVGRYGARPSLVIAGVTITAAATMLTFLTA-T
MSMEG_5670|M.smegmatis_MC2_155 IYLPIAIGALIFSPLSGRMVGRFGSRPSLVSAGVLITAATVMLAQMTA-T
MAB_0945|M.abscessus_ATCC_1997 IYLPIAVGALVFSPISGRMVGRFGARPSLLAAGTLFLTASLLLTRVSE-A
Rv2333c|M.tuberculosis_H37Rv MILPFSAAVAIVSPLVGHLVGRIGARVPILAGLCMLMLGLLMLIFSEH-R
Mb2361c|M.bovis_AF2122/97 MILPFSAAVAIVSPLVGHLVGRIGARVPILAGLCMLMLGLLMLIFSEH-R
MMAR_3642|M.marinum_M MILPFSAGVAVVSPLVGSLVARVGARVLILIGLGLLMLGLLTLIASEH-R
MUL_1468|M.ulcerans_Agy99 ----------VVD-------------------------------------
TH_2682|M.thermoresistible__bu ALTPLTIPLLLLSVTTQWYLPRLGLRAVISTGLLLIAAGLFYARTLEI-A
MAV_1387|M.avium_104 LIAPMAIANGVFAPFVGKIVDRYHPRPVLGFGFSLLAIALTWLTFEMSPA
MLBr_01562|M.leprae_Br4923 GFIPFVIAMGIGLGVSSQLVSRFSPRVLTIGGGWLLMVAMLYGWAFMNRG
.
Mflv_1730|M.gilvum_PYR-GCK TPVWH-LLIVFAVFGVGFSMVNAPITNAAVSGMPLDRAGAASAVTSTSRQ
Mvan_5021|M.vanbaalenii_PYR-1 TPVWS-LLMVFAVFGIGFSMVNAPVTNAAVSGMPLDRAGAASAVTSTSRQ
MSMEG_5670|M.smegmatis_MC2_155 TPVWL-LLVIFAVFGIGFALVNAPITTAAVSGMPLDRAGAASAVASTSRQ
MAB_0945|M.abscessus_ATCC_1997 TPIWE-LLVTFAIFGAGFAMVNAPITNAAVSGMPLDRAGAASAVTSTSRQ
Rv2333c|M.tuberculosis_H37Rv SSALV-LVG-LGLCGSGVALCLTPITTVAMTAVPAERAGMASGIMSAQRA
Mb2361c|M.bovis_AF2122/97 SSALV-LVG-LGLCGSGVALCLTPITTVAMTAVPAERAGMASGIMSAQRA
MMAR_3642|M.marinum_M SWALV-LVG-LGFCGTGVALCLTPITTVAMTAVPPERAGMASGIMSAQRA
MUL_1468|M.ulcerans_Agy99 --------------------------------------------------
TH_2682|M.thermoresistible__bu SPYLD-LAVPLLIMSTGIGLCTAPSTSAIMGAVPDEKHGVASAVNDTTRE
MAV_1387|M.avium_104 TPIWR-LVLPFFAMGVGMAFVWSPLTATATRNLSAQLAGAGSAVYNSVRQ
MLBr_01562|M.leprae_Br4923 VPYFPNLLAPIVVGGIGIGMAVVPLTLSAIAGVGFDRIGPVSAIALMLQS
Mflv_1730|M.gilvum_PYR-GCK VGVSIGVA--------LCGSVAGAAMAGSGTDFATAARPLWFVCIALGLV
Mvan_5021|M.vanbaalenii_PYR-1 VGVSIGVA--------LCGSLAGSAMATGGADFAAAARPLWFVCMALGLV
MSMEG_5670|M.smegmatis_MC2_155 VGVSIGVA--------LCGSVAGTALAGTGVDFAAASRPLWLICTALGVV
MAB_0945|M.abscessus_ATCC_1997 VGVSIGVA--------LCGSIG--------------TPALWFMCAGLGLL
Rv2333c|M.tuberculosis_H37Rv IGSTIGFA--------VLGSVLAAWLSATLEPHLERAVPDPVQRHVLAEI
Mb2361c|M.bovis_AF2122/97 IGSTIGFA--------VLGSVLAAWLSATLEPHLERAVPDPVQRHVLAEI
MMAR_3642|M.marinum_M IGSTIGFA--------VLGSVLAAWLSATLEPHLEPAVPDPVQRHTIAEV
MUL_1468|M.ulcerans_Agy99 --------------------------------------------------
TH_2682|M.thermoresistible__bu IGAALGIA--------VAGSVLAAEYGDRLRPHLG-ALPEPVR--QAASN
MAV_1387|M.avium_104 LGAVLGSAGMAAFMTWRIGAEMPGQPGGGGEDSAGPVLPEFLRGPFAAAM
MLBr_01562|M.leprae_Br4923 LGGPLVLAVIQ---AVITSRTLYLGGTTGPVKFMNDAQLRALDHGYTYGL
Mflv_1730|M.gilvum_PYR-GCK ILAVG---------------------------------------------
Mvan_5021|M.vanbaalenii_PYR-1 ILGLG---------------------------------------------
MSMEG_5670|M.smegmatis_MC2_155 IVAIG---------------------------------------------
MAB_0945|M.abscessus_ATCC_1997 IATLG---------------------------------------------
Rv2333c|M.tuberculosis_H37Rv IIDSANPRAHVGG-------------------------------------
Mb2361c|M.bovis_AF2122/97 IIDSANPRAHVGG-------------------------------------
MMAR_3642|M.marinum_M IIDSANPRAHVGG-------------------------------------
MUL_1468|M.ulcerans_Agy99 --------------------------------------------------
TH_2682|M.thermoresistible__bu SLAEALEAARQLG-------------------------------------
MAV_1387|M.avium_104 SQSVLLPAFIALFGIVAALFLVGFRPWAHRDGGTDAFGPDDYGGDYHDDY
MLBr_01562|M.leprae_Br4923 LWVAG---------------------------------------------
Mflv_1730|M.gilvum_PYR-GCK --------FFSTSQRAVRSAERLAPLVAGAPDPVNGAHVR----------
Mvan_5021|M.vanbaalenii_PYR-1 --------LFATSQRALRSAERLAPLVSGAPEPVGGAHVR----------
MSMEG_5670|M.smegmatis_MC2_155 --------IVSTSPWALRSAERLAPLIGQHHRPAEVAHAR----------
MAB_0945|M.abscessus_ATCC_1997 --------IVSTSPAAVRSAQRLAPLIEGT-TAREMSRVG----------
Rv2333c|M.tuberculosis_H37Rv ---IVPRRHIEHRDPVAIAEEDFIEGIRVALLVATATLAVVFLAGWR---
Mb2361c|M.bovis_AF2122/97 ---IVPRRHIEHRDPVAIAEEDFIEGIRVALLVATATLAVVFLAGWR---
MMAR_3642|M.marinum_M ---IVPRREIVHRDPVAIAEEDFIEGIRVAFFIATASLGFVFLAGWR---
MUL_1468|M.ulcerans_Agy99 --------------------------------------------------
TH_2682|M.thermoresistible__bu ---PQGARLAEFAQSAFLEAMHVSLIVLGALCALAAAFVAVWAPGRDGRQ
MAV_1387|M.avium_104 DDDDAYVELILVREPEPEAQQRAGQPRRPQPTPAPPADVRRRDPVESRRS
MLBr_01562|M.leprae_Br4923 --------AVVIVGVAALFIGYTPEQVAYAQEVKEAVDAGEL--------
Mflv_1730|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5021|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_5670|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0945|M.abscessus_ATCC_1997 --------------------------------------------------
Rv2333c|M.tuberculosis_H37Rv -WFPRDVHTAGSDLSERLPTAMTVECAVSHMPGATWCRLWPA--------
Mb2361c|M.bovis_AF2122/97 -WFPRDVQTAGSDAKR--EAAYSDDRRVRG--------------------
MMAR_3642|M.marinum_M -WFPRGGAGMLGDAEREADAVGL---------------------------
MUL_1468|M.ulcerans_Agy99 --------------------------------------------------
TH_2682|M.thermoresistible__bu YGFVERWTSRWSGEEAGGAVAEHDDGGVRAATGDGWEHGTVDDP------
MAV_1387|M.avium_104 VLDERPAQVQPIGFAHNGSHVDGGKRLRQVAVRRAPKPGPPADRFTRPPR
MLBr_01562|M.leprae_Br4923 --------------------------------------------------
Mflv_1730|M.gilvum_PYR-GCK ----------------------------------------
Mvan_5021|M.vanbaalenii_PYR-1 ----------------------------------------
MSMEG_5670|M.smegmatis_MC2_155 ----------------------------------------
MAB_0945|M.abscessus_ATCC_1997 ----------------------------------------
Rv2333c|M.tuberculosis_H37Rv ----------------------------------------
Mb2361c|M.bovis_AF2122/97 ----------------------------------------
MMAR_3642|M.marinum_M ----------------------------------------
MUL_1468|M.ulcerans_Agy99 ----------------------------------------
TH_2682|M.thermoresistible__bu ----------------------------------------
MAV_1387|M.avium_104 RHHPGPAGHHLGEGESLRGQHHRPDPDDDPTGYGRHSSGN
MLBr_01562|M.leprae_Br4923 ----------------------------------------