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MSATVHTVDPALVDMMEAVFAQYRTSHPPTEASRRDPALWQRLEQLGLARLTGAEDSGGSGASWYEAAEL LAAAVRNAVRIPLAEHDLLACWLLDAHDMGADAAVRTVCLLDADGVATEVPWASHADRIVVIRQSAGEYH LADVDAQTLTITPGANMIGEPRNTVRADHLDLRGVPTTGAVVSTLKFKSALVRAIQVCAALDQILHLSVE HVSSRVQFGRPLAKFQAVQNLIADIAAETALARAATEAALTKAVTSQWSAQNLDFLVAVARSCVGHAVSV VVRNAHQVHGAIGTTEEHRLHEFTRAALAWRSEFGSVHYWDEQVTKAALHAGGSGLWGLITG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_3512 | - | - | 100% (342) | acyl-CoA dehydrogenase |
| M. marinum M | MMAR_5053 | fadE33 | 4e-17 | 31.27% (275) | acyl-CoA dehydrogenase FadE33 |
| M. marinum M | MMAR_5052 | fadE32 | 1e-16 | 28.62% (297) | acyl-CoA dehydrogenase FadE32 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1968c | fadE18 | 7e-16 | 28.40% (324) | acyl-CoA dehydrogenase FADE18 |
| M. gilvum PYR-GCK | Mflv_5167 | - | 1e-119 | 64.88% (336) | acyl-CoA dehydrogenase domain-containing protein |
| M. tuberculosis H37Rv | Rv1933c | fadE18 | 7e-16 | 28.40% (324) | acyl-CoA dehydrogenase FADE18 |
| M. leprae Br4923 | MLBr_00737 | fadE25 | 3e-07 | 25.64% (156) | putative acyl-CoA dehydrogenase |
| M. abscessus ATCC 19977 | MAB_0594c | - | 3e-14 | 25.91% (301) | acyl-CoA dehydrogenase FadE |
| M. avium 104 | MAV_1813 | - | 1e-45 | 36.31% (314) | putative acyl-CoA dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_2878 | - | 1e-122 | 67.26% (336) | putative acyl-CoA dehydrogenase |
| M. thermoresistible (build 8) | TH_3909 | - | 3e-45 | 35.85% (318) | PUTATIVE acyl-CoA dehydrogenase |
| M. ulcerans Agy99 | MUL_2756 | - | 0.0 | 97.95% (342) | acyl-CoA dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_3918 | - | 1e-120 | 66.17% (337) | acyl-CoA dehydrogenase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1968c|M.bovis_AF2122/97 -------MDFRYSTEQDDFRASLRGFLGRG---APVREMAA-ADGSDRRL
Rv1933c|M.tuberculosis_H37Rv -------MDFRYSTEQDDFRASLRGFLGRG---APVREMAA-ADGSDRRL
MAB_0594c|M.abscessus_ATCC_199 -------MKFDLDTQQRDFAASIDAALSVADVPAAARAWAA-GNHGPGLA
MMAR_3512|M.marinum_M -------MSATVHTVDPALVDMMEAVFAQYRTSHPPT-----EASRRDPA
MUL_2756|M.ulcerans_Agy99 -------MSATVHTVDPALVNMMEAVFAQYRTSHPPT-----EASRRDPA
MSMEG_2878|M.smegmatis_MC2_155 ------------MTVDAELVAMMNAVFADHRTAHGPT-----AG----PE
Mvan_3918|M.vanbaalenii_PYR-1 ---------MTAPQVDPALAEMMDAVFAEHGRDG---------------D
Mflv_5167|M.gilvum_PYR-GCK --------MTGPTSVDPDLVEMLDAVFADHREQLGAQR----PAATWDAG
MAV_1813|M.avium_104 -MSALAGGVFASGTVEDDGAELRQLVDDIGRRSFDAKLGRRRVPDEFDAD
TH_3909|M.thermoresistible__bu ------------------------------------------VPEQFDTN
MLBr_00737|M.leprae_Br4923 MVGWSGNPLFDLFKLPEEHNELRATIRALAEKEIAPHAADVDQRARFPEE
Mb1968c|M.bovis_AF2122/97 WQRLCTELELPALHVPPEHGGLGATLVETAIAFAELGRALTPIPFAATV-
Rv1933c|M.tuberculosis_H37Rv WQRLCTELELPALHVPPEHGGLGATLVETAIAFAELGRALTPIPFAATV-
MAB_0594c|M.abscessus_ATCC_199 VWSTLAELGVTALAVSEKYDGIGAHPVDLVVALEGLGKWAVPGPVVESV-
MMAR_3512|M.marinum_M LWQRLEQLGLARLTGAEDSGGSGASWYEAAELLAAAVRNAVRIPLAEHD-
MUL_2756|M.ulcerans_Agy99 LWQRLEQLGLARLTGAEDSGGSGASWYEAAELLAAAVRNAVRIPLAEHD-
MSMEG_2878|M.smegmatis_MC2_155 LWDQLRALGLARLTGAEESGGSGAGWHEAAELMAAAVRSGVRVGLPEHD-
Mvan_3918|M.vanbaalenii_PYR-1 LWSRLDGLGLVRLTGAEESGGSGAGWHEAAELLSAAVRHGVRMPLAEND-
Mflv_5167|M.gilvum_PYR-GCK LWDRLGQLGLTRLTGSEESGGSGAGWREGAELLRAAVQNGVQVPLAEHD-
MAV_1813|M.avium_104 LWRNLEDTGLARLTSTPD---LDAGPHELAIVLYGLARHAGAVPLAETD-
TH_3909|M.thermoresistible__bu LWHHLQESGLTRLTSSGD---VEAGPNELAVVLAGIAQHSGAIPLAETD-
MLBr_00737|M.leprae_Br4923 ALAALNASGFNAIHVPEEYGGQGADSVAACIVIEEVARVDASASLIPAVN
. : . . * : : .
Mb1968c|M.bovis_AF2122/97 -FAIEAILRMGDDEQRKRLLAGLLTGARIGTIAVSGHDVASATTVRAVRR
Rv1933c|M.tuberculosis_H37Rv -FAIEAILRMGDDEQRKRLLAGLLTGARIGTIAVSGHDVASATTVRAVRR
MAB_0594c|M.abscessus_ATCC_199 -AVAPVLLSSHEDG--AEPSTRLASGELIATVAAP---------------
MMAR_3512|M.marinum_M -LLACWLLDAHDMGADAAVRTVCLLDA-------DGVATEVP--------
MUL_2756|M.ulcerans_Agy99 -LLACWLLDSHDMGADAAVRTVCLLDA-------DGVATEVP--------
MSMEG_2878|M.smegmatis_MC2_155 -LLACWLLEVAGIAVDDNTRTVALLDE-------SGTATAVP--------
Mvan_3918|M.vanbaalenii_PYR-1 -LLASWVLDAAGIGYDAALRTVCLLDE-------RGNADAVP--------
Mflv_5167|M.gilvum_PYR-GCK -LLACWLLESAGLPVDDARRTVCVLD--------DGVAHGVP--------
MAV_1813|M.avium_104 -ALAGWLGREAGIELPNGPLTVAIADSDLAGGRLTGTAMDVP--------
TH_3909|M.thermoresistible__bu -ALAGWLGQRADVDLPVGPLTVAVADAEETAGYVRGIAPDVP--------
MLBr_00737|M.leprae_Br4923 KLGTMGLILRGSEELKKQVLPSLAAEGAMASYALSEREAGSDAASMRTRA
: .
Mb1968c|M.bovis_AF2122/97 DGRPALTGEC------TPVLHGHVADLFVVPAVADGSIVLHVVAADAPGV
Rv1933c|M.tuberculosis_H37Rv DGRPALTGEC------TPVLHGHVADLFVVPAVADGSIVLHVVAADAPGV
MAB_0594c|M.abscessus_ATCC_199 ---------------------------PIAPRALDADIAGLVLIADDIGI
MMAR_3512|M.marinum_M -----------------------WASHADRIVVIRQS-AGEYHLADVDAQ
MUL_2756|M.ulcerans_Agy99 -----------------------WASRADRIVVIRQS-AGEYRLADVDAQ
MSMEG_2878|M.smegmatis_MC2_155 -----------------------WASTAQRIVLVWRTQTGEHRVADVDAA
Mvan_3918|M.vanbaalenii_PYR-1 -----------------------WASHADRIVVVWPR-GGGYLAADVVAD
Mflv_5167|M.gilvum_PYR-GCK -----------------------WASEADRIVVVWRT-NGTAQVADVAAG
MAV_1813|M.avium_104 -----------------------WSGAATAVLLAARG-RDGSRVCVLDGG
TH_3909|M.thermoresistible__bu -----------------------WARSSAAVLLVART-ADRTLVGTVDNA
MLBr_00737|M.leprae_Br4923 KADGDDWILNGFKCWITNGGKSTWYTVMAVTDPDKGANGISAFIVHKDDE
Mb1968c|M.bovis_AF2122/97 TVTPLPSFD---ITRPVATLRLAGSPAEPLTAGTPDDME------RVLDV
Rv1933c|M.tuberculosis_H37Rv TVTPLPSFD---ITRPVATLRLAGSPAEPLTAGTPDDME------RVLDV
MAB_0594c|M.abscessus_ATCC_199 REAQAGAQH---ESIDATRRVFDVQPKE---AGISLDTS------RAIDF
MMAR_3512|M.marinum_M TLTITPGAN---MIGEPRNTVRADHLDLRGVPTTGAVVS------TLKFK
MUL_2756|M.ulcerans_Agy99 TLTITPGAN---MIGEPRNTVRADHLDLRGVPTAGAVVS------TLKFK
MSMEG_2878|M.smegmatis_MC2_155 AVRITAGAN---MIGEPRDTVSAD-VPADGATVSEATVT------TLHLK
Mvan_3918|M.vanbaalenii_PYR-1 SVTIAPGVN---MIGEPRDDVTADVGALRGIDIGTELVA------QLALK
Mflv_5167|M.gilvum_PYR-GCK DLAVTSGAN---LAGEPRDTVAADPAALTGTTVPNALID------QLLLR
MAV_1813|M.avium_104 ETSADDGYN---LAGEPRGRLTFDVAADELTPVDDAVAD------ELSRR
TH_3909|M.thermoresistible__bu TSDLADGHN---LAGEPRSRLTFDIPVEKLAAVDSTLGV------ELWVR
MLBr_00737|M.leprae_Br4923 GFSIGPKEKKLGIKGSPTTELYFDKCRIPGDRIIGEPGTGFKTALATLDH
.
Mb1968c|M.bovis_AF2122/97 ARVLLAAEMLGGAEACLDLAVQYAGRRTQFDRPIGSFQAVKHACADMMIE
Rv1933c|M.tuberculosis_H37Rv ARVLLAAEMLGGAEACLDLAVQYAGRRTQFDRPIGSFQAVKHACADMMIE
MAB_0594c|M.abscessus_ATCC_199 GVLAISAQLIGAGQALLDRAVAYAKQRSQFGRPIGSYQAVKHKLADVHIA
MMAR_3512|M.marinum_M SALVRAIQVCAALDQILHLSVEHVSSRVQFGRPLAKFQAVQNLIADIAAE
MUL_2756|M.ulcerans_Agy99 SALVRAIQVCAALDQILHLSVEHVSSRVQFGRPLAKFHAVQNLIADIAAE
MSMEG_2878|M.smegmatis_MC2_155 AALVRAVQVCAAMDTILELAVEHSSSRIQFGRPLAKFQAIQHMISDIAAE
Mvan_3918|M.vanbaalenii_PYR-1 SALTRAIQVCAALDRALELSIEHTTSREQFGRPLAKFQAVQHLISDIAAE
Mflv_5167|M.gilvum_PYR-GCK GALVRGLQVCAALDRIVALSIAHTTDRTQFGRPLAKFQSVQNLVSDSAAE
MAV_1813|M.avium_104 GGWCRCIQIVGALDAAAALTVAHTRERVQFGRPLSAFQAVQQSLAGMAGE
TH_3909|M.thermoresistible__bu GAWCRCVQTIGTLDAVVAMSVNHTAERIQFGRTLSRFQSVQHGLAAMAGE
MLBr_00737|M.leprae_Br4923 TRPTIGAQAVGIAQGALDAAIVYTKDRKQFGESISTFQSIQFMLADMAMK
: . : :: : * **...:. ::::: :
Mb1968c|M.bovis_AF2122/97 IDATRATVMFAAMSAAN----GDELQTVAPLAKAQTAETFVLCAGSALQI
Rv1933c|M.tuberculosis_H37Rv IDATRATVMFAAMSAAN----GDELQTVAPLAKAQTAETFVLCAGSALQI
MAB_0594c|M.abscessus_ATCC_199 LELARPLVYGAALSLADQ---SPTAARDASAAKVAAAKAAYLAARSALQT
MMAR_3512|M.marinum_M TALARAATEAALTKAVTSQWSAQNLDFLVAVARSCVGHAVSVVVRNAHQV
MUL_2756|M.ulcerans_Agy99 TALARAATEAALTKAVTSQWSAQNLDFLVAVARSCVGHVVSVVVRNAHQV
MSMEG_2878|M.smegmatis_MC2_155 ATLARTATEAALTAAVDTTWSAPHLEFLVAVARSCCGHAASVVVRNAHQV
Mvan_3918|M.vanbaalenii_PYR-1 AALARSATEAALAAAVASDWSSPQLEFLVAAARSCAGHAASVVVRNAHQV
Mflv_5167|M.gilvum_PYR-GCK AALARAATEAALTEAVRTGWSGTNLEFLVAVARSCTGHATSVVVRNAHQV
MAV_1813|M.avium_104 IERARAAVELAVAAAAEHGFGSPHTDYAVTVAKVAVGRAVIPVTTTAHQL
TH_3909|M.thermoresistible__bu IERARAAASLAVAAAADNGFESARTEFAVTAARAAVGRAVTPVTTIAHQL
MLBr_00737|M.leprae_Br4923 VEAARLIVYAAAARAERG---EPDLGFISAASKCFASDIAMEVTTDAVQL
:* . * . :: . . * *
Mb1968c|M.bovis_AF2122/97 HGAIAFTWEHDLHLYYRRAKTTEALFGSSARNRALLAERAGLVKA-----
Rv1933c|M.tuberculosis_H37Rv HGAIAFTWEHDLHLYYRRAKTTEALFGSSARNRALLAERAGLVKA-----
MAB_0594c|M.abscessus_ATCC_199 HGAIGFTAEYDLSLWILKVRALTSAWGTSEWHRARVLEAL----------
MMAR_3512|M.marinum_M HGAIGTTEEHRLHEFTRAALAWRSEFGSVHYWDEQVTKAALHAGGSGLWG
MUL_2756|M.ulcerans_Agy99 HGAIGTTEEHRLHEFTRAALAWRSEFGSVHYWDEQVTKAALHAGGSGLWG
MSMEG_2878|M.smegmatis_MC2_155 FGAIGTTAEHRLHEYTRAALAWRGEFGSVRSWDERVTTAALQAGGAGLWE
Mvan_3918|M.vanbaalenii_PYR-1 HGAIGTTSEHRLHEYTRAALAWRSEFGSVRHWDARLTDMAMQAGPHRLWE
Mflv_5167|M.gilvum_PYR-GCK HGAIGTTREHRLHEFTQPALAWRSEFGSVHYWDELLTTAALAAGRDGLWP
MAV_1813|M.avium_104 HGAIGVTSEHPLWLFTLRAQSWADDYGTTAHHARRLGRMALAAGDP--WD
TH_3909|M.thermoresistible__bu HGAIGVTTEHPLWSATMRARSWAGEFGTTNGYARRLGRMALQAHDP--WD
MLBr_00737|M.leprae_Br4923 FGGAGYTSDFPVERFMRDAKITQIYEGTNQIQRVVMSRALLR--------
.*. . * :. : . *: :
Mb1968c|M.bovis_AF2122/97 --------------
Rv1933c|M.tuberculosis_H37Rv --------------
MAB_0594c|M.abscessus_ATCC_199 --------------
MMAR_3512|M.marinum_M LITG----------
MUL_2756|M.ulcerans_Agy99 LITG----------
MSMEG_2878|M.smegmatis_MC2_155 LITS----------
Mvan_3918|M.vanbaalenii_PYR-1 LICP----------
Mflv_5167|M.gilvum_PYR-GCK LITA----------
MAV_1813|M.avium_104 LVIGNLTRPKTVDK
TH_3909|M.thermoresistible__bu LVIGNI--------
MLBr_00737|M.leprae_Br4923 --------------