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SATVHTVDPALVNMMEAVFAQYRTSHPPTEASRRDPALWQRLEQLGLARLTGAEDSGGSGASWYEAAELL AAAVRNAVRIPLAEHDLLACWLLDSHDMGADAAVRTVCLLDADGVATEVPWASRADRIVVIRQSAGEYRL ADVDAQTLTITPGANMIGEPRNTVRADHLDLRGVPTAGAVVSTLKFKSALVRAIQVCAALDQILHLSVEH VSSRVQFGRPLAKFHAVQNLIADIAAETALARAATEAALTKAVTSQWSAQNLDFLVAVARSCVGHVVSVV VRNAHQVHGAIGTTEEHRLHEFTRAALAWRSEFGSVHYWDEQVTKAALHAGGSGLWGLITG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_2756 | - | - | 100% (342) | acyl-CoA dehydrogenase |
| M. ulcerans Agy99 | MUL_4129 | fadE33 | 4e-16 | 30.50% (282) | acyl-CoA dehydrogenase FadE33 |
| M. ulcerans Agy99 | MUL_4128 | fadE32 | 1e-15 | 27.49% (291) | acyl-CoA dehydrogenase FadE32 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3594 | fadE33 | 8e-15 | 29.29% (280) | acyl-CoA dehydrogenase FADE33 |
| M. gilvum PYR-GCK | Mflv_5167 | - | 1e-118 | 64.58% (336) | acyl-CoA dehydrogenase domain-containing protein |
| M. tuberculosis H37Rv | Rv3564 | fadE33 | 8e-15 | 29.29% (280) | acyl-CoA dehydrogenase FADE33 |
| M. leprae Br4923 | MLBr_00737 | fadE25 | 3e-07 | 25.81% (155) | putative acyl-CoA dehydrogenase |
| M. abscessus ATCC 19977 | MAB_0594c | - | 8e-14 | 27.85% (298) | acyl-CoA dehydrogenase FadE |
| M. marinum M | MMAR_3512 | - | 0.0 | 97.95% (342) | acyl-CoA dehydrogenase |
| M. avium 104 | MAV_1813 | - | 3e-45 | 35.99% (314) | putative acyl-CoA dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_2878 | - | 1e-121 | 66.96% (336) | putative acyl-CoA dehydrogenase |
| M. thermoresistible (build 8) | TH_3909 | - | 2e-44 | 35.22% (318) | PUTATIVE acyl-CoA dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_3918 | - | 1e-117 | 64.99% (337) | acyl-CoA dehydrogenase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3594|M.bovis_AF2122/97 ---------MTPPEERQMLRETVASLVAKHAGPAAVR-AAMASDRGYDES
Rv3564|M.tuberculosis_H37Rv ---------MTPPEERQMLRETVASLVAKHAGPAAVR-AAMASDRGYDES
MUL_2756|M.ulcerans_Agy99 -------MSATVHTVDPALVNMMEAVFAQYRTSHPPT-----EASRRDPA
MMAR_3512|M.marinum_M -------MSATVHTVDPALVDMMEAVFAQYRTSHPPT-----EASRRDPA
MSMEG_2878|M.smegmatis_MC2_155 ------------MTVDAELVAMMNAVFADHRTAHGPT-----AG----PE
Mvan_3918|M.vanbaalenii_PYR-1 ---------MTAPQVDPALAEMMDAVFAEHGRDG---------------D
Mflv_5167|M.gilvum_PYR-GCK --------MTGPTSVDPDLVEMLDAVFADHREQLGAQR----PAATWDAG
MAV_1813|M.avium_104 -MSALAGGVFASGTVEDDGAELRQLVDDIGRRSFDAKLGRRRVPDEFDAD
TH_3909|M.thermoresistible__bu ------------------------------------------VPEQFDTN
MAB_0594c|M.abscessus_ATCC_199 -------MKFDLDTQQRDFAASIDAALSVADVPAAAR-AWAAGNHGPGLA
MLBr_00737|M.leprae_Br4923 MVGWSGNPLFDLFKLPEEHNELRATIRALAEKEIAPHAADVDQRARFPEE
Mb3594|M.bovis_AF2122/97 LWRLLCEQVGAAALVIPEELGGAGGELADAAIVVQELGRALVPSPLLGTT
Rv3564|M.tuberculosis_H37Rv LWRLLCEQVGAAALVIPEELGGAGGELADAAIVVQELGRALVPSPLLGTT
MUL_2756|M.ulcerans_Agy99 LWQRLEQ-LGLARLTGAEDSGGSGASWYEAAELLAAAVRNAVRIPLAEHD
MMAR_3512|M.marinum_M LWQRLEQ-LGLARLTGAEDSGGSGASWYEAAELLAAAVRNAVRIPLAEHD
MSMEG_2878|M.smegmatis_MC2_155 LWDQLRA-LGLARLTGAEESGGSGAGWHEAAELMAAAVRSGVRVGLPEHD
Mvan_3918|M.vanbaalenii_PYR-1 LWSRLDG-LGLVRLTGAEESGGSGAGWHEAAELLSAAVRHGVRMPLAEND
Mflv_5167|M.gilvum_PYR-GCK LWDRLGQ-LGLTRLTGSEESGGSGAGWREGAELLRAAVQNGVQVPLAEHD
MAV_1813|M.avium_104 LWRNLED-TGLARLTS---TPDLDAGPHELAIVLYGLARHAGAVPLAETD
TH_3909|M.thermoresistible__bu LWHHLQE-SGLTRLTS---SGDVEAGPNELAVVLAGIAQHSGAIPLAETD
MAB_0594c|M.abscessus_ATCC_199 VWSTLAE-LGVTALAVSEKYDGIGAHPVDLVVALEGLGKWAVPGPVVESV
MLBr_00737|M.leprae_Br4923 ALAALNA-SGFNAIHVPEEYGGQGADSVAACIVIEEVARVDASASLIPAV
* * : . . : : :
Mb3594|M.bovis_AF2122/97 ----------------------------LAELALLAAAKPDAQALTELAQ
Rv3564|M.tuberculosis_H37Rv ----------------------------LAELALLAAAKPDAQALTELAQ
MUL_2756|M.ulcerans_Agy99 ----------------------------LLACWLLDSHDMGADAAVRTVC
MMAR_3512|M.marinum_M ----------------------------LLACWLLDAHDMGADAAVRTVC
MSMEG_2878|M.smegmatis_MC2_155 ----------------------------LLACWLLEVAGIAVDDNTRTVA
Mvan_3918|M.vanbaalenii_PYR-1 ----------------------------LLASWVLDAAGIGYDAALRTVC
Mflv_5167|M.gilvum_PYR-GCK ----------------------------LLACWLLESAGLPVDDARRTVC
MAV_1813|M.avium_104 ----------------------------ALAGWLGREAGIELPNGPLTVA
TH_3909|M.thermoresistible__bu ----------------------------ALAGWLGQRADVDLPVGPLTVA
MAB_0594c|M.abscessus_ATCC_199 ----------------------------AVAPVLLSSHEDGAEPSTRLAS
MLBr_00737|M.leprae_Br4923 NKLGTMGLILRGSEELKKQVLPSLAAEGAMASYALSEREAGSDAASMRTR
.
Mb3594|M.bovis_AF2122/97 GSAIG-----ALVLDPDYVVNGDIADIVVAATS-------GQLTRWTRFS
Rv3564|M.tuberculosis_H37Rv GSAIG-----ALVLDPDYVVNGDIADIVVAATS-------GQLTRWTRFS
MUL_2756|M.ulcerans_Agy99 LLDA-------DGVATEVPWASRADRIVVIRQS-------AGEYRLADVD
MMAR_3512|M.marinum_M LLDA-------DGVATEVPWASHADRIVVIRQS-------AGEYHLADVD
MSMEG_2878|M.smegmatis_MC2_155 LLDE-------SGTATAVPWASTAQRIVLVWRTQ------TGEHRVADVD
Mvan_3918|M.vanbaalenii_PYR-1 LLDE-------RGNADAVPWASHADRIVVVWPR-------GGGYLAADVV
Mflv_5167|M.gilvum_PYR-GCK VLD--------DGVAHGVPWASEADRIVVVWRT-------NGTAQVADVA
MAV_1813|M.avium_104 IADSDLAGGRLTGTAMDVPWSGAATAVLLAARG-------RDGSRVCVLD
TH_3909|M.thermoresistible__bu VADAEETAGYVRGIAPDVPWARSSAAVLLVART-------ADRTLVGTVD
MAB_0594c|M.abscessus_ATCC_199 GELIAT-----VAAPPIAPRALDADIAGLVLIAD------DIGIREAQAG
MLBr_00737|M.leprae_Br4923 AKADGDD-WILNGFKCWITNGGKSTWYTVMAVTDPDKGANGISAFIVHKD
:
Mb3594|M.bovis_AF2122/97 AQPVATMDPTR---RLARLQSEETEPLCPDPG------IADT--------
Rv3564|M.tuberculosis_H37Rv AQPVATMDPTR---RLARLQSEETEPLCPDPG------IADT--------
MUL_2756|M.ulcerans_Agy99 AQTLTITPGAN---MIGEPRNTVRADHLDLRG------VPTAGAVVSTLK
MMAR_3512|M.marinum_M AQTLTITPGAN---MIGEPRNTVRADHLDLRG------VPTTGAVVSTLK
MSMEG_2878|M.smegmatis_MC2_155 AAAVRITAGAN---MIGEPRDTVSAD-VPADG------ATVSEATVTTLH
Mvan_3918|M.vanbaalenii_PYR-1 ADSVTIAPGVN---MIGEPRDDVTADVGALRG------IDIGTELVAQLA
Mflv_5167|M.gilvum_PYR-GCK AGDLAVTSGAN---LAGEPRDTVAADPAALTG------TTVPNALIDQLL
MAV_1813|M.avium_104 GGETSADDGYN---LAGEPRGRLTFDVAADEL------TPVDDAVADELS
TH_3909|M.thermoresistible__bu NATSDLADGHN---LAGEPRSRLTFDIPVEKL------AAVDSTLGVELW
MAB_0594c|M.abscessus_ATCC_199 AQHESIDATRR---VFDVQPKEAGISLDTSRA------IDFG--------
MLBr_00737|M.leprae_Br4923 DEGFSIGPKEKKLGIKGSPTTELYFDKCRIPGDRIIGEPGTGFKTALATL
.
Mb3594|M.bovis_AF2122/97 --AAILLAAEQIGAAERCLQLTVEYAKSRVQFGRPIGSFQALKHRMADLY
Rv3564|M.tuberculosis_H37Rv --AAILLAAEQIGAAERCLQLTVEYAKSRVQFGRPIGSFQALKHRMADLY
MUL_2756|M.ulcerans_Agy99 FKSALVRAIQVCAALDQILHLSVEHVSSRVQFGRPLAKFHAVQNLIADIA
MMAR_3512|M.marinum_M FKSALVRAIQVCAALDQILHLSVEHVSSRVQFGRPLAKFQAVQNLIADIA
MSMEG_2878|M.smegmatis_MC2_155 LKAALVRAVQVCAAMDTILELAVEHSSSRIQFGRPLAKFQAIQHMISDIA
Mvan_3918|M.vanbaalenii_PYR-1 LKSALTRAIQVCAALDRALELSIEHTTSREQFGRPLAKFQAVQHLISDIA
Mflv_5167|M.gilvum_PYR-GCK LRGALVRGLQVCAALDRIVALSIAHTTDRTQFGRPLAKFQSVQNLVSDSA
MAV_1813|M.avium_104 RRGGWCRCIQIVGALDAAAALTVAHTRERVQFGRPLSAFQAVQQSLAGMA
TH_3909|M.thermoresistible__bu VRGAWCRCVQTIGTLDAVVAMSVNHTAERIQFGRTLSRFQSVQHGLAAMA
MAB_0594c|M.abscessus_ATCC_199 ---VLAISAQLIGAGQALLDRAVAYAKQRSQFGRPIGSYQAVKHKLADVH
MLBr_00737|M.leprae_Br4923 DHTRPTIGAQAVGIAQGALDAAIVYTKDRKQFGESISTFQSIQFMLADMA
: . : :: : .* ***..:. ::::: ::
Mb3594|M.bovis_AF2122/97 VTIAAARAVVADACHAPTPTN---------AATARLAASEALSTAAAEGI
Rv3564|M.tuberculosis_H37Rv VTIAAARAVVADACHAPTPTN---------AATARLAASEALSTAAAEGI
MUL_2756|M.ulcerans_Agy99 AETALARAATEAALTKAVTSQWSAQNLDFLVAVARSCVGHVVSVVVRNAH
MMAR_3512|M.marinum_M AETALARAATEAALTKAVTSQWSAQNLDFLVAVARSCVGHAVSVVVRNAH
MSMEG_2878|M.smegmatis_MC2_155 AEATLARTATEAALTAAVDTTWSAPHLEFLVAVARSCCGHAASVVVRNAH
Mvan_3918|M.vanbaalenii_PYR-1 AEAALARSATEAALAAAVASDWSSPQLEFLVAAARSCAGHAASVVVRNAH
Mflv_5167|M.gilvum_PYR-GCK AEAALARAATEAALTEAVRTGWSGTNLEFLVAVARSCTGHATSVVVRNAH
MAV_1813|M.avium_104 GEIERARAAVELAVAAAAEHGFGSPHTDYAVTVAKVAVGRAVIPVTTTAH
TH_3909|M.thermoresistible__bu GEIERARAAASLAVAAAADNGFESARTEFAVTAARAAVGRAVTPVTTIAH
MAB_0594c|M.abscessus_ATCC_199 IALELARPLVYGAALSLADQSPTAAR---DASAAKVAAAKAAYLAARSAL
MLBr_00737|M.leprae_Br4923 MKVEAARLIVYAAAARAERGE---PDLGFISAASKCFASDIAMEVTTDAV
** . * :.:: . .. .
Mb3594|M.bovis_AF2122/97 QLHGGIAITWEHDMHLYFKRAHGSAQLLESPREVLRRLESEVWESP----
Rv3564|M.tuberculosis_H37Rv QLHGGIAITWEHDMHLYFKRAHGSAQLLESPREVLRRLESEVWESP----
MUL_2756|M.ulcerans_Agy99 QVHGAIGTTEEHRLHEFTRAALAWRSEFGSVHYWDEQVTKAALHAGGSGL
MMAR_3512|M.marinum_M QVHGAIGTTEEHRLHEFTRAALAWRSEFGSVHYWDEQVTKAALHAGGSGL
MSMEG_2878|M.smegmatis_MC2_155 QVFGAIGTTAEHRLHEYTRAALAWRGEFGSVRSWDERVTTAALQAGGAGL
Mvan_3918|M.vanbaalenii_PYR-1 QVHGAIGTTSEHRLHEYTRAALAWRSEFGSVRHWDARLTDMAMQAGPHRL
Mflv_5167|M.gilvum_PYR-GCK QVHGAIGTTREHRLHEFTQPALAWRSEFGSVHYWDELLTTAALAAGRDGL
MAV_1813|M.avium_104 QLHGAIGVTSEHPLWLFTLRAQSWADDYGTTAHHARRLGRMALAAGDP--
TH_3909|M.thermoresistible__bu QLHGAIGVTTEHPLWSATMRARSWAGEFGTTNGYARRLGRMALQAHDP--
MAB_0594c|M.abscessus_ATCC_199 QTHGAIGFTAEYDLSLWILKVRALTSAWGTSEWHRARVLEAL--------
MLBr_00737|M.leprae_Br4923 QLFGGAGYTSDFPVERFMRDAKITQIYEGTNQIQRVVMSRALLR------
* .*. . * :. : . : :
Mb3594|M.bovis_AF2122/97 ----------------
Rv3564|M.tuberculosis_H37Rv ----------------
MUL_2756|M.ulcerans_Agy99 WGLITG----------
MMAR_3512|M.marinum_M WGLITG----------
MSMEG_2878|M.smegmatis_MC2_155 WELITS----------
Mvan_3918|M.vanbaalenii_PYR-1 WELICP----------
Mflv_5167|M.gilvum_PYR-GCK WPLITA----------
MAV_1813|M.avium_104 WDLVIGNLTRPKTVDK
TH_3909|M.thermoresistible__bu WDLVIGNI--------
MAB_0594c|M.abscessus_ATCC_199 ----------------
MLBr_00737|M.leprae_Br4923 ----------------