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MTGPTSVDPDLVEMLDAVFADHREQLGAQRPAATWDAGLWDRLGQLGLTRLTGSEESGGSGAGWREGAEL LRAAVQNGVQVPLAEHDLLACWLLESAGLPVDDARRTVCVLDDGVAHGVPWASEADRIVVVWRTNGTAQV ADVAAGDLAVTSGANLAGEPRDTVAADPAALTGTTVPNALIDQLLLRGALVRGLQVCAALDRIVALSIAH TTDRTQFGRPLAKFQSVQNLVSDSAAEAALARAATEAALTEAVRTGWSGTNLEFLVAVARSCTGHATSVV VRNAHQVHGAIGTTREHRLHEFTQPALAWRSEFGSVHYWDELLTTAALAAGRDGLWPLITA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_5167 | - | - | 100% (341) | acyl-CoA dehydrogenase domain-containing protein |
| M. gilvum PYR-GCK | Mflv_3793 | - | 2e-17 | 26.33% (319) | acyl-CoA dehydrogenase domain-containing protein |
| M. gilvum PYR-GCK | Mflv_2335 | - | 3e-14 | 25.62% (320) | acyl-CoA dehydrogenase domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1968c | fadE18 | 7e-11 | 28.57% (161) | acyl-CoA dehydrogenase FADE18 |
| M. tuberculosis H37Rv | Rv3061c | fadE22 | 4e-11 | 29.86% (345) | acyl-CoA dehydrogenase FADE22 |
| M. leprae Br4923 | MLBr_00737 | fadE25 | 2e-07 | 27.21% (147) | putative acyl-CoA dehydrogenase |
| M. abscessus ATCC 19977 | MAB_0580 | - | 8e-11 | 24.18% (306) | acyl-CoA dehydrogenase FadE |
| M. marinum M | MMAR_3512 | - | 1e-119 | 64.88% (336) | acyl-CoA dehydrogenase |
| M. avium 104 | MAV_1813 | - | 6e-51 | 37.77% (323) | putative acyl-CoA dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_2878 | - | 1e-115 | 64.20% (338) | putative acyl-CoA dehydrogenase |
| M. thermoresistible (build 8) | TH_4629 | - | 3e-50 | 38.44% (320) | PUTATIVE putative acyl-CoA dehydrogenase |
| M. ulcerans Agy99 | MUL_2756 | - | 1e-118 | 64.58% (336) | acyl-CoA dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_3918 | - | 1e-113 | 62.65% (340) | acyl-CoA dehydrogenase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Rv3061c|M.tuberculosis_H37Rv -------MGIALTDDHRELS-GVARAFLTSQKVRWAARASLDAAGDARPP
MAB_0580|M.abscessus_ATCC_1997 -MSVPSGLRASGSSEVQEAARDAVRQWARSAAVIESVRK-MESEPDGWGP
MMAR_3512|M.marinum_M -------MSATVHTVDPALVDMMEAVFAQYRTSHPPT-----EASRRDPA
MUL_2756|M.ulcerans_Agy99 -------MSATVHTVDPALVNMMEAVFAQYRTSHPPT-----EASRRDPA
MSMEG_2878|M.smegmatis_MC2_155 ------------MTVDAELVAMMNAVFADHRTAHGPT-----AG----PE
Mvan_3918|M.vanbaalenii_PYR-1 ---------MTAPQVDPALAEMMDAVFAEHGRDG---------------D
Mflv_5167|M.gilvum_PYR-GCK --------MTGPTSVDPDLVEMLDAVFADHREQLGAQR----PAATWDAG
MAV_1813|M.avium_104 -MSALAGGVFASGTVEDDGAELRQLVDDIGRRSFDAKLGRRRVPDEFDAD
TH_4629|M.thermoresistible__bu --------VFATDTA-DDYTDLRQLVDDIGRRSFDARIGTRRVPDQFDDE
Mb1968c|M.bovis_AF2122/97 -------MDFRYSTEQDDFRASLRGFLGRGAPVREMA-----AADGSDRR
MLBr_00737|M.leprae_Br4923 MVGWSGNPLFDLFKLPEEHNELRATIRALAEKEIAPHAADVDQRARFPEE
Rv3061c|M.tuberculosis_H37Rv FWQNLA-ELGWLGLHIDERHGGSGYGLSELVVVIEELGRAVAPGLFVPTV
MAB_0580|M.abscessus_ATCC_1997 AYVGLA-ELGIFGVAVPEAAGGSGAGFDDMIAMVDEAAASLVPGPVATSA
MMAR_3512|M.marinum_M LWQRLE-QLGLARLTGAEDSGGSGASWYEAAELLAAAVRNAVRIPLAEHD
MUL_2756|M.ulcerans_Agy99 LWQRLE-QLGLARLTGAEDSGGSGASWYEAAELLAAAVRNAVRIPLAEHD
MSMEG_2878|M.smegmatis_MC2_155 LWDQLR-ALGLARLTGAEESGGSGAGWHEAAELMAAAVRSGVRVGLPEHD
Mvan_3918|M.vanbaalenii_PYR-1 LWSRLD-GLGLVRLTGAEESGGSGAGWHEAAELLSAAVRHGVRMPLAEND
Mflv_5167|M.gilvum_PYR-GCK LWDRLG-QLGLTRLTGSEESGGSGAGWREGAELLRAAVQNGVQVPLAEHD
MAV_1813|M.avium_104 LWRNLE-DTGLARLTSTPD---LDAGPHELAIVLYGLARHAGAVPLAETD
TH_4629|M.thermoresistible__bu LWGNLS-DTGLTRLTSDPD---LGAGPNELAVVLSGIARYAGAVPLAETD
Mb1968c|M.bovis_AF2122/97 LWQRLCTELELPALHVPPEHGGLGATLVETAIAFAELGRALTPIPFAATV
MLBr_00737|M.leprae_Br4923 ALAALN-ASGFNAIHVPEEYGGQGADSVAACIVIEEVARVDASASLIPAV
* : . . .
Rv3061c|M.tuberculosis_H37Rv --IASAVVAKEGTDDQRARLLPALIDGTLTAGVGLDSQVQV---------
MAB_0580|M.abscessus_ATCC_1997 --LVAVVLAADG----HEELVPPLAAGERTAGLALTGNLAI---------
MMAR_3512|M.marinum_M --LLACWLLDAHD----------MGADAAVRTVCLLDA------------
MUL_2756|M.ulcerans_Agy99 --LLACWLLDSHD----------MGADAAVRTVCLLDA------------
MSMEG_2878|M.smegmatis_MC2_155 --LLACWLLEVAG----------IAVDDNTRTVALLDE------------
Mvan_3918|M.vanbaalenii_PYR-1 --LLASWVLDAAG----------IGYDAALRTVCLLDE------------
Mflv_5167|M.gilvum_PYR-GCK --LLACWLLESAG----------LPVDDARRTVCVLD-------------
MAV_1813|M.avium_104 --ALAGWLGREAG----------IELPNGPLTVAIADSDLA---------
TH_4629|M.thermoresistible__bu --ALAGWLGREAG----------LDLPDGPLTVAIAEHSGD---------
Mb1968c|M.bovis_AF2122/97 --FAIEAILRMGDDEQRKRLLAGLLTGARIGTIAVSGHDVASATTVRAVR
MLBr_00737|M.leprae_Br4923 NKLGTMGLILRGSEELKKQVLPSLAAEGAMASYALSEREAGSDAASMRTR
: : :
Rv3061c|M.tuberculosis_H37Rv --TDG----VADGEAGIVLGAGLAELLLVAAG-------DDVLVLERGRK
MAB_0580|M.abscessus_ATCC_1997 --ADG----LASGVLPAVLGGTADGVLLAPVP-------DGWVLVDCAEA
MMAR_3512|M.marinum_M ----------DGVATEVPWASHADRIVVIRQS-------AGEYHLADVDA
MUL_2756|M.ulcerans_Agy99 ----------DGVATEVPWASRADRIVVIRQS-------AGEYRLADVDA
MSMEG_2878|M.smegmatis_MC2_155 ----------SGTATAVPWASTAQRIVLVWRTQ------TGEHRVADVDA
Mvan_3918|M.vanbaalenii_PYR-1 ----------RGNADAVPWASHADRIVVVWPR-------GGGYLAADVVA
Mflv_5167|M.gilvum_PYR-GCK ----------DGVAHGVPWASEADRIVVVWRT-------NGTAQVADVAA
MAV_1813|M.avium_104 --GGR----LTGTAMDVPWSGAATAVLLAARG-------RDGSRVCVLDG
TH_4629|M.thermoresistible__bu --G-------PVKAVDVPWARAAAAVLLAVRT-------PDGARIGITS-
Mb1968c|M.bovis_AF2122/97 RDGRP----ALTGECTPVLHGHVADLFVVPAVA------DGSIVLHVVAA
MLBr_00737|M.leprae_Br4923 AKADGDDWILNGFKCWITNGGKSTWYTVMAVTDPDKGANGISAFIVHKDD
:
Rv3061c|M.tuberculosis_H37Rv GVSVDVPE---NFDPTRRSGRVRLDNVRVTTDDI------LLGAYESALA
MAB_0580|M.abscessus_ATCC_1997 GVAVEAKK---ATDFSRPWVTVTLHGAAVRPVG-------LPAAVIADLS
MMAR_3512|M.marinum_M QTLTITPG---ANMIGEPRNTVRADHLDLRGVPT------TGAVVSTLKF
MUL_2756|M.ulcerans_Agy99 QTLTITPG---ANMIGEPRNTVRADHLDLRGVPT------AGAVVSTLKF
MSMEG_2878|M.smegmatis_MC2_155 AAVRITAG---ANMIGEPRDTVSAD-VPADGATV------SEATVTTLHL
Mvan_3918|M.vanbaalenii_PYR-1 DSVTIAPG---VNMIGEPRDDVTADVGALRGIDI------GTELVAQLAL
Mflv_5167|M.gilvum_PYR-GCK GDLAVTSG---ANLAGEPRDTVAADPAALTGTTV------PNALIDQLLL
MAV_1813|M.avium_104 GETSADDG---YNLAGEPRGRLTFDVAADELTPV------DDAVADELSR
TH_4629|M.thermoresistible__bu -NPQVVDG---HNAAGEPRGRVTVDLGAVTLASV------DDAVLTELTL
Mb1968c|M.bovis_AF2122/97 DAPGVTVTPLPSFDITRPVATLRLAGSPAEPLTAG-----TPDDMERVLD
MLBr_00737|M.leprae_Br4923 EGFSIGPKEKKLGIKGSPTTELYFDKCRIPGDRIIGEPGTGFKTALATLD
:
Rv3061c|M.tuberculosis_H37Rv RARTLLAAEAVGGAADCVDSAVAYAKVRQQFGRTIATFQAVKHHCANMLV
MAB_0580|M.abscessus_ATCC_1997 --VVTLSAEAVGVARWALQTAVEYAKVREQFGKQIGSFQAIKHMCAEMLC
MMAR_3512|M.marinum_M KSALVRAIQVCAALDQILHLSVEHVSSRVQFGRPLAKFQAVQNLIADIAA
MUL_2756|M.ulcerans_Agy99 KSALVRAIQVCAALDQILHLSVEHVSSRVQFGRPLAKFHAVQNLIADIAA
MSMEG_2878|M.smegmatis_MC2_155 KAALVRAVQVCAAMDTILELAVEHSSSRIQFGRPLAKFQAIQHMISDIAA
Mvan_3918|M.vanbaalenii_PYR-1 KSALTRAIQVCAALDRALELSIEHTTSREQFGRPLAKFQAVQHLISDIAA
Mflv_5167|M.gilvum_PYR-GCK RGALVRGLQVCAALDRIVALSIAHTTDRTQFGRPLAKFQSVQNLVSDSAA
MAV_1813|M.avium_104 RGGWCRCIQIVGALDAAAALTVAHTRERVQFGRPLSAFQAVQQSLAGMAG
TH_4629|M.thermoresistible__bu RGAWCRAVQIVGALDTAAAMTVRHTAEREQFGRSLSKFQAVQHALAGMAG
Mb1968c|M.bovis_AF2122/97 VARVLLAAEMLGGAEACLDLAVQYAGRRTQFDRPIGSFQAVKHACADMMI
MLBr_00737|M.leprae_Br4923 HTRPTIGAQAVGIAQGALDAAIVYTKDRKQFGESISTFQSIQFMLADMAM
: . :: : * **.. :. *:::: :
Rv3061c|M.tuberculosis_H37Rv AAESAIAAVWDAARAAAE------DEEQFRLAAAVAAALAFPAYARNAEL
MAB_0580|M.abscessus_ATCC_1997 RVEQADVAVWDAAGCAQDVLANKGDSQQLSLAAAVAAAVAVDAAVANTKD
MMAR_3512|M.marinum_M ETALARAATEAALTKAVTS---QWSAQNLDFLVAVARSCVGHAVSVVVRN
MUL_2756|M.ulcerans_Agy99 ETALARAATEAALTKAVTS---QWSAQNLDFLVAVARSCVGHVVSVVVRN
MSMEG_2878|M.smegmatis_MC2_155 EATLARTATEAALTAAVDT---TWSAPHLEFLVAVARSCCGHAASVVVRN
Mvan_3918|M.vanbaalenii_PYR-1 EAALARSATEAALAAAVAS---DWSSPQLEFLVAAARSCAGHAASVVVRN
Mflv_5167|M.gilvum_PYR-GCK EAALARAATEAALTEAVRT---GWSGTNLEFLVAVARSCTGHATSVVVRN
MAV_1813|M.avium_104 EIERARAAVELAVAAAAEH---GFGSPHTDYAVTVAKVAVGRAVIPVTTT
TH_4629|M.thermoresistible__bu EIERARAAASLAVAAAADY---GFAAPRTEFAITAARVTAGRAVTAVTTS
Mb1968c|M.bovis_AF2122/97 EIDATRATVMFAAMSAANG-------DELQTVAPLAKAQTAETFVLCAGS
MLBr_00737|M.leprae_Br4923 KVEAARLIVYAAAARAERG------EPDLGFISAASKCFASDIAMEVTTD
: . * * . : .
Rv3061c|M.tuberculosis_H37Rv NIQVHGGIGFTWEHDAHLHLRRALVTVGLFGGDAPVR-DVFERTAAGVTR
MAB_0580|M.abscessus_ATCC_1997 CIQILGGIGFTWEHDAHLYLRRAYALQSFVGKPAVWRRKAAALTIGGIRR
MMAR_3512|M.marinum_M AHQVHGAIGTTEEHRLHEFTRAALAWRSEFG-------------------
MUL_2756|M.ulcerans_Agy99 AHQVHGAIGTTEEHRLHEFTRAALAWRSEFG-------------------
MSMEG_2878|M.smegmatis_MC2_155 AHQVFGAIGTTAEHRLHEYTRAALAWRGEFG-------------------
Mvan_3918|M.vanbaalenii_PYR-1 AHQVHGAIGTTSEHRLHEYTRAALAWRSEFG-------------------
Mflv_5167|M.gilvum_PYR-GCK AHQVHGAIGTTREHRLHEFTQPALAWRSEFG-------------------
MAV_1813|M.avium_104 AHQLHGAIGVTSEHPLWLFTLRAQSWADDYG-------------------
TH_4629|M.thermoresistible__bu AHQLHGAIGVTAEHPLWSVTLRAQAWADEFG-------------------
Mb1968c|M.bovis_AF2122/97 ALQIHGAIAFTWEHDLHLYYRRAKTTEALFG-------------------
MLBr_00737|M.leprae_Br4923 AVQLFGGAGYTSDFPVERFMRDAKITQIYEG-------------------
*: *. . * :. * *
Rv3061c|M.tuberculosis_H37Rv AISLDLPAQAEELRARIRSDAAEIAALEKDAQRDKLIETGYVMPHWPRPW
MAB_0580|M.abscessus_ATCC_1997 SLTIDL-GEVESQRAEVAGQVAEIASAPKAEHQVRLAEAGFLAPHWPAPY
MMAR_3512|M.marinum_M --------------------------------------------------
MUL_2756|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_2878|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_3918|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_5167|M.gilvum_PYR-GCK --------------------------------------------------
MAV_1813|M.avium_104 --------------------------------------------------
TH_4629|M.thermoresistible__bu --------------------------------------------------
Mb1968c|M.bovis_AF2122/97 --------------------------------------------------
MLBr_00737|M.leprae_Br4923 --------------------------------------------------
Rv3061c|M.tuberculosis_H37Rv GRAAGAVEQLVIEEEFSAAGIERPDYSITGWVILTLIQHGTPWQIERFVE
MAB_0580|M.abscessus_ATCC_1997 GLGAGAAQQLLIDQELHAAGVNRPDLVIGWWAAPTILEHGTPEQIAQFVA
MMAR_3512|M.marinum_M --SVHYWDEQVTKAALHAGGSGLWGLITG---------------------
MUL_2756|M.ulcerans_Agy99 --SVHYWDEQVTKAALHAGGSGLWGLITG---------------------
MSMEG_2878|M.smegmatis_MC2_155 --SVRSWDERVTTAALQAGGAGLWELITS---------------------
Mvan_3918|M.vanbaalenii_PYR-1 --SVRHWDARLTDMAMQAGPHRLWELICP---------------------
Mflv_5167|M.gilvum_PYR-GCK --SVHYWDELLTTAALAAGRDGLWPLITA---------------------
MAV_1813|M.avium_104 --TTAHHARRLGRMALAAGDP--WDLVIGNLTRPKTVDK-----------
TH_4629|M.thermoresistible__bu --TTAGYARRLGRLALESANP--WDLVIGNV-------------------
Mb1968c|M.bovis_AF2122/97 -SSARNRALLAERAGLVKA-------------------------------
MLBr_00737|M.leprae_Br4923 ---TNQIQRVVMSRALLR--------------------------------
. :
Rv3061c|M.tuberculosis_H37Rv KALRQQEIWCQLFSEPDAGSDAASVKTRATRVEGGWKINGQKVWTSGAQY
MAB_0580|M.abscessus_ATCC_1997 PTLRGEIEWCQLFSEPGAGSDLAALRTKATRVDGGWKLDGQKVWNSKAQI
MMAR_3512|M.marinum_M --------------------------------------------------
MUL_2756|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_2878|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_3918|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_5167|M.gilvum_PYR-GCK --------------------------------------------------
MAV_1813|M.avium_104 --------------------------------------------------
TH_4629|M.thermoresistible__bu --------------------------------------------------
Mb1968c|M.bovis_AF2122/97 --------------------------------------------------
MLBr_00737|M.leprae_Br4923 --------------------------------------------------
Rv3061c|M.tuberculosis_H37Rv CARGLATVRTDPDAPKHAGITTVIIDMLAPGVEVRPLRQITGDSEFNEVF
MAB_0580|M.abscessus_ATCC_1997 ADWAICLARTNPDVPKHKGITYFLLDMKTPGITVRPLREITGEEMFNEVF
MMAR_3512|M.marinum_M --------------------------------------------------
MUL_2756|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_2878|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_3918|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_5167|M.gilvum_PYR-GCK --------------------------------------------------
MAV_1813|M.avium_104 --------------------------------------------------
TH_4629|M.thermoresistible__bu --------------------------------------------------
Mb1968c|M.bovis_AF2122/97 --------------------------------------------------
MLBr_00737|M.leprae_Br4923 --------------------------------------------------
Rv3061c|M.tuberculosis_H37Rv FNDVFVPDEDVVGAPNSGWTVARATLGNERVSIGGSGSYYEAMAAKLVQL
MAB_0580|M.abscessus_ATCC_1997 LDGVIVPDENVVGSVDDGWRLARTTLANERVAMAGGGTLDEAMESLLALI
MMAR_3512|M.marinum_M --------------------------------------------------
MUL_2756|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_2878|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_3918|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_5167|M.gilvum_PYR-GCK --------------------------------------------------
MAV_1813|M.avium_104 --------------------------------------------------
TH_4629|M.thermoresistible__bu --------------------------------------------------
Mb1968c|M.bovis_AF2122/97 --------------------------------------------------
MLBr_00737|M.leprae_Br4923 --------------------------------------------------
Rv3061c|M.tuberculosis_H37Rv VQRRSDAFAGAPIRVGAFLAEDHALRLLNLRRAARSVEGAGPGPEGNITK
MAB_0580|M.abscessus_ATCC_1997 GDTELDAAQLD--TLGAFVCSAQTGALLDLRTALRAIGGQDPGAASSVRK
MMAR_3512|M.marinum_M --------------------------------------------------
MUL_2756|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_2878|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_3918|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_5167|M.gilvum_PYR-GCK --------------------------------------------------
MAV_1813|M.avium_104 --------------------------------------------------
TH_4629|M.thermoresistible__bu --------------------------------------------------
Mb1968c|M.bovis_AF2122/97 --------------------------------------------------
MLBr_00737|M.leprae_Br4923 --------------------------------------------------
Rv3061c|M.tuberculosis_H37Rv LKVAEHMIEGAAIAAALWGPEIALLDGPGRVIGR---TVMGARGMAIAGG
MAB_0580|M.abscessus_ATCC_1997 LVGVRHRQG-------LSEHILDYVDTHGAVESREMWLFMRDRCLSIAGG
MMAR_3512|M.marinum_M --------------------------------------------------
MUL_2756|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_2878|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_3918|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_5167|M.gilvum_PYR-GCK --------------------------------------------------
MAV_1813|M.avium_104 --------------------------------------------------
TH_4629|M.thermoresistible__bu --------------------------------------------------
Mb1968c|M.bovis_AF2122/97 --------------------------------------------------
MLBr_00737|M.leprae_Br4923 --------------------------------------------------
Rv3061c|M.tuberculosis_H37Rv TSEVTRNQIAERILGMPRDPLIS
MAB_0580|M.abscessus_ATCC_1997 TTQILLSVAGERLLGLPR-----
MMAR_3512|M.marinum_M -----------------------
MUL_2756|M.ulcerans_Agy99 -----------------------
MSMEG_2878|M.smegmatis_MC2_155 -----------------------
Mvan_3918|M.vanbaalenii_PYR-1 -----------------------
Mflv_5167|M.gilvum_PYR-GCK -----------------------
MAV_1813|M.avium_104 -----------------------
TH_4629|M.thermoresistible__bu -----------------------
Mb1968c|M.bovis_AF2122/97 -----------------------
MLBr_00737|M.leprae_Br4923 -----------------------