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TVDAELVAMMNAVFADHRTAHGPTAGPELWDQLRALGLARLTGAEESGGSGAGWHEAAELMAAAVRSGVR VGLPEHDLLACWLLEVAGIAVDDNTRTVALLDESGTATAVPWASTAQRIVLVWRTQTGEHRVADVDAAAV RITAGANMIGEPRDTVSADVPADGATVSEATVTTLHLKAALVRAVQVCAAMDTILELAVEHSSSRIQFGR PLAKFQAIQHMISDIAAEATLARTATEAALTAAVDTTWSAPHLEFLVAVARSCCGHAASVVVRNAHQVFG AIGTTAEHRLHEYTRAALAWRGEFGSVRSWDERVTTAALQAGGAGLWELITS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_2878 | - | - | 100% (333) | putative acyl-CoA dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_3393 | - | 3e-58 | 43.12% (320) | putative acyl-CoA dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_1905 | - | 2e-17 | 27.60% (337) | acyl-CoA dehydrogenase protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0277c | fadE6 | 2e-19 | 28.57% (322) | acyl-CoA dehydrogenase FADE6 |
| M. gilvum PYR-GCK | Mflv_5167 | - | 1e-115 | 64.20% (338) | acyl-CoA dehydrogenase domain-containing protein |
| M. tuberculosis H37Rv | Rv0271c | fadE6 | 2e-19 | 28.57% (322) | acyl-CoA dehydrogenase FADE6 |
| M. leprae Br4923 | MLBr_00737 | fadE25 | 4e-09 | 27.45% (153) | putative acyl-CoA dehydrogenase |
| M. abscessus ATCC 19977 | MAB_4336 | - | 2e-14 | 27.68% (336) | acyl-CoA dehydrogenase FadE |
| M. marinum M | MMAR_3512 | - | 1e-122 | 67.26% (336) | acyl-CoA dehydrogenase |
| M. avium 104 | MAV_2553 | - | 8e-48 | 37.82% (312) | acyl-CoA dehydrogenase, C- |
| M. thermoresistible (build 8) | TH_4629 | - | 6e-50 | 39.61% (308) | PUTATIVE putative acyl-CoA dehydrogenase |
| M. ulcerans Agy99 | MUL_2756 | - | 1e-121 | 66.96% (336) | acyl-CoA dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_2875 | - | 1e-116 | 62.83% (339) | acyl-CoA dehydrogenase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_3512|M.marinum_M ----------MSATVHTVDPALVDMMEAVFAQYRTSH----PPTEASRRD
MUL_2756|M.ulcerans_Agy99 ----------MSATVHTVDPALVNMMEAVFAQYRTSH----PPTEASRRD
MSMEG_2878|M.smegmatis_MC2_155 ---------------MTVDAELVAMMNAVFADHRTAH----GPTAG----
Mflv_5167|M.gilvum_PYR-GCK -----------MTGPTSVDPDLVEMLDAVFADHREQLG---AQRPAATWD
Mvan_2875|M.vanbaalenii_PYR-1 ------MTDVHADPGMAVDADLLEMMDAVLADYRQGH----PPAGVVRFD
MAV_2553|M.avium_104 -MSALAGGVFAVTGSQDDDAELRQLVDDLGRRSYDAGLG--RRGIPDQFD
TH_4629|M.thermoresistible__bu --------VFATD-TADDYTDLRQLVDDIGRRSFDARIG--TRRVPDQFD
Mb0277c|M.bovis_AF2122/97 ----------MSIAITPEHYELADSVRSLVARVAPSEVLHAALESPVENP
Rv0271c|M.tuberculosis_H37Rv ----------MSIAITPEHYELADSVRSLVARVAPSEVLHAALESPVENP
MAB_4336|M.abscessus_ATCC_1997 ----------MPIAINSEHVALADSAHAFVERVVPTELLHETLETPLPWP
MLBr_00737|M.leprae_Br4923 MVGWSGNPLFDLFKLPEEHNELRATIRALAEKEIAPHAA--DVDQRARFP
* .
MMAR_3512|M.marinum_M PALWQRLEQLGLARLTGAEDSGGSGASWYEAAELLAAAVRNAVRIPLAEH
MUL_2756|M.ulcerans_Agy99 PALWQRLEQLGLARLTGAEDSGGSGASWYEAAELLAAAVRNAVRIPLAEH
MSMEG_2878|M.smegmatis_MC2_155 PELWDQLRALGLARLTGAEESGGSGAGWHEAAELMAAAVRSGVRVGLPEH
Mflv_5167|M.gilvum_PYR-GCK AGLWDRLGQLGLTRLTGSEESGGSGAGWREGAELLRAAVQNGVQVPLAEH
Mvan_2875|M.vanbaalenii_PYR-1 AELWESLHQLGLVRLTGAPGSGGSGAGWAESAALISSATRHAVRVPLAEH
MAV_2553|M.avium_104 AELWRNLEDTGLTRLTSTPDMG---AGPHELAIALYGVSRHAGAVPLAET
TH_4629|M.thermoresistible__bu DELWGNLSDTGLTRLTSDPDLG---AGPNELAVVLSGIARYAGAVPLAET
Mb0277c|M.bovis_AF2122/97 PPYWQAAAEQGLQGVHLAESVGGQGFGILELAVVLAEFGYGAVPGPFVPS
Rv0271c|M.tuberculosis_H37Rv PPYWQAAAEQGLQGVHLAESVGGQGFGILELAVVLAEFGYGAVPGPFVPS
MAB_4336|M.abscessus_ATCC_1997 PPFWKSAADQGLTSVHLAESVGGQGFGALELAIVVAEFGRGAVPGPFVPS
MLBr_00737|M.leprae_Br4923 EEALAALNASGFNAIHVPEEYGGQGADSVAACIVIEEVARVDASASLIPA
*: : * . . : :
MMAR_3512|M.marinum_M D-----LLACWLLDAH-------DMGADAAVRTVCLLDA-----------
MUL_2756|M.ulcerans_Agy99 D-----LLACWLLDSH-------DMGADAAVRTVCLLDA-----------
MSMEG_2878|M.smegmatis_MC2_155 D-----LLACWLLEVA-------GIAVDDNTRTVALLDE-----------
Mflv_5167|M.gilvum_PYR-GCK D-----LLACWLLESA-------GLPVDDARRTVCVLD------------
Mvan_2875|M.vanbaalenii_PYR-1 D-----LLACWLLEAA-------GLPVDDAVRTVCVLDE-----------
MAV_2553|M.avium_104 D-----ALAGWLGQQA-------GIELPNGPLTVAVADAET---------
TH_4629|M.thermoresistible__bu D-----ALAGWLGREA-------GLDLPDGPLTVAIAEHSG---------
Mb0277c|M.bovis_AF2122/97 A-----IASALIAAHDPQAKVLAELATGAAIAAYALDSGLT---------
Rv0271c|M.tuberculosis_H37Rv A-----IASALIAAHDPQAKVLAELATGAAIAAYALDSGLT---------
MAB_4336|M.abscessus_ATCC_1997 V-----IASALISAHDPDHPLLSDLASGASIATFSSTSSFT---------
MLBr_00737|M.leprae_Br4923 VNKLGTMGLILRGSEELKKQVLPSLAAEGAMASYALSEREAGSDAASMRT
: : . .
MMAR_3512|M.marinum_M -----------DGVATEVPWASHADRIVVIRQS-AGEYH------LADVD
MUL_2756|M.ulcerans_Agy99 -----------DGVATEVPWASRADRIVVIRQS-AGEYR------LADVD
MSMEG_2878|M.smegmatis_MC2_155 -----------SGTATAVPWASTAQRIVLVWRTQTGEHR------VADVD
Mflv_5167|M.gilvum_PYR-GCK -----------DGVAHGVPWASEADRIVVVWRT-NGTAQ------VADVA
Mvan_2875|M.vanbaalenii_PYR-1 -----------AGTATAVPWAAYAGRVVAIWSD-GDSHR------VADID
MAV_2553|M.avium_104 -DGAR-----VTGTATGVPWARACAAALLAVTT-PAGLR------VGVID
TH_4629|M.thermoresistible__bu -DGP--------VKAVDVPWARAAAAVLLAVRT-PDGAR------IGITS
Mb0277c|M.bovis_AF2122/97 -ATRHGDVLVIRGEVRAVPAAAQASVLVLPVAIESRDEW------VVLRN
Rv0271c|M.tuberculosis_H37Rv -ATRHGDVLVIRGEVRAVPAAAQASVLVLPVAIESRDEW------VVLRN
MAB_4336|M.abscessus_ATCC_1997 -ATPAGDGLSVDGQARSVLSATSATYVVAPVAIDSDRRW------VVLSA
MLBr_00737|M.leprae_Br4923 RAKADGDDWILNGFKCWITNGGKSTWYTVMAVTDPDKGANGISAFIVHKD
: . . :
MMAR_3512|M.marinum_M AQTLTITPGA---NMIGEPRNTVRADHLDLRG--VPTTG----AVVSTLK
MUL_2756|M.ulcerans_Agy99 AQTLTITPGA---NMIGEPRNTVRADHLDLRG--VPTAG----AVVSTLK
MSMEG_2878|M.smegmatis_MC2_155 AAAVRITAGA---NMIGEPRDTVSAD-VPADG--ATVSE----ATVTTLH
Mflv_5167|M.gilvum_PYR-GCK AGDLAVTSGA---NLAGEPRDTVAADPAALTG--TTVPN----ALIDQLL
Mvan_2875|M.vanbaalenii_PYR-1 RGSLHIAPGT---NMIGEPRDTVTADISALAPHSTAIDA----DLVEQLR
MAV_2553|M.avium_104 VASGDLQEGH---NLAGEPRDSVPFDVSADQL--HAVDP----ALGAELT
TH_4629|M.thermoresistible__bu NPQ--VVDGH---NAAGEPRGRVTVDLGAVTL--ASVDD----AVLTELT
Mb0277c|M.bovis_AF2122/97 DQLEIEAVKS---LDPLRPIAHVRANAVDVSDD-ALLSN----LTMTTAH
Rv0271c|M.tuberculosis_H37Rv DQLEIEAVKS---LDPLRPIAHVRANAVDVSDD-ALLSN----LTMTTAH
MAB_4336|M.abscessus_ATCC_1997 DDVTLDSQQS---VDPLRPVAHVTATAVQVPAD-RVLSN----LTDARAT
MLBr_00737|M.leprae_Br4923 DEGFSIGPKEKKLGIKGSPTTELYFDKCRIPGDRIIGEPGTGFKTALATL
* :
MMAR_3512|M.marinum_M FKSALVRAIQVCAALDQILHLSVEHVSSRVQFGRPLAKFQAVQNLIADIA
MUL_2756|M.ulcerans_Agy99 FKSALVRAIQVCAALDQILHLSVEHVSSRVQFGRPLAKFHAVQNLIADIA
MSMEG_2878|M.smegmatis_MC2_155 LKAALVRAVQVCAAMDTILELAVEHSSSRIQFGRPLAKFQAIQHMISDIA
Mflv_5167|M.gilvum_PYR-GCK LRGALVRGLQVCAALDRIVALSIAHTTDRTQFGRPLAKFQSVQNLVSDSA
Mvan_2875|M.vanbaalenii_PYR-1 LKCALVRAIQVCSALDTILVLAVEHTTSRVQFGRSLSKFQAVQHMIADMA
MAV_2553|M.avium_104 RRGAWSRCVQTIGVLDAAAALSVEHTRQRVQFGRPLSAFQSVQQSLAGMA
TH_4629|M.thermoresistible__bu LRGAWCRAVQIVGALDTAAAMTVRHTAEREQFGRSLSKFQAVQHALAGMA
Mb0277c|M.bovis_AF2122/97 ALMSTLLSAEAVGVARWATDTASAYAKIREQFGRPIGQFQAIKHKCAEMI
Rv0271c|M.tuberculosis_H37Rv ALMSTLLSAEAVGVARWATDTASAYAKIREQFGRPIGQFQAIKHKCAEMI
MAB_4336|M.abscessus_ATCC_1997 SIISTIVSAEAVGVARWATDTASEYAKVREQFGRPIGQFQGIKHKCATMA
MLBr_00737|M.leprae_Br4923 DHTRPTIGAQAVGIAQGALDAAIVYTKDRKQFGESISTFQSIQFMLADMA
: . : : * ***..:. *:.:: :
MMAR_3512|M.marinum_M AETALARAATEAALTKAVTSQWSAQNLDFLVAVARSCVGHAVSVVVRNAH
MUL_2756|M.ulcerans_Agy99 AETALARAATEAALTKAVTSQWSAQNLDFLVAVARSCVGHVVSVVVRNAH
MSMEG_2878|M.smegmatis_MC2_155 AEATLARTATEAALTAAVDTTWSAPHLEFLVAVARSCCGHAASVVVRNAH
Mflv_5167|M.gilvum_PYR-GCK AEAALARAATEAALTEAVRTGWSGTNLEFLVAVARSCTGHATSVVVRNAH
Mvan_2875|M.vanbaalenii_PYR-1 GEAALASASTEAALAAAIASGWAADNLGFLVAVARSCTGHAASVVVRNAH
MAV_2553|M.avium_104 GEIERARAAAELAVAAASEHGFNSPHTDYAVTVAKVAVGRAVGPVTSVAH
TH_4629|M.thermoresistible__bu GEIERARAAASLAVAAAADYGFAAPRTEFAITAARVTAGRAVTAVTTSAH
Mb0277c|M.bovis_AF2122/97 ADTERATAAVWDAARALDDAGESSSDVEFAAAVAATLAPATAQRCTQDCI
Rv0271c|M.tuberculosis_H37Rv ADTERATAAVWDAARALDDAGESSSDVEFAAAVAATLAPATAQRCTQDCI
MAB_4336|M.abscessus_ATCC_1997 AVTERATAAVWDAARALDDADENPGVVEFAASVAATLAPAAAQQCAQDCI
MLBr_00737|M.leprae_Br4923 MKVEAARLIVYAAAARAERG---EPDLGFISAASKCFASDIAMEVTTDAV
* . * : :.: . . .
MMAR_3512|M.marinum_M QVHGAIGTTEEHRLHEFTRAALAWRSEFGSVHYWDEQVTKAALHAGGSGL
MUL_2756|M.ulcerans_Agy99 QVHGAIGTTEEHRLHEFTRAALAWRSEFGSVHYWDEQVTKAALHAGGSGL
MSMEG_2878|M.smegmatis_MC2_155 QVFGAIGTTAEHRLHEYTRAALAWRGEFGSVRSWDERVTTAALQAGGAGL
Mflv_5167|M.gilvum_PYR-GCK QVHGAIGTTREHRLHEFTQPALAWRSEFGSVHYWDELLTTAALAAGRDGL
Mvan_2875|M.vanbaalenii_PYR-1 QALGAIGTTIEHRLHEYTRAALTWRSEYGSVQHWDEVVTRNALDAGTRGL
MAV_2553|M.avium_104 QLHGAIGVTSEHPLWLFTLRAQSWTADYGTTANYARRLGRLVLAAEDP--
TH_4629|M.thermoresistible__bu QLHGAIGVTAEHPLWSVTLRAQAWADEFGTTAGYARRLGRLALESANP--
Mb0277c|M.bovis_AF2122/97 QVHGGIGFTWEHDTNVYYRRALMLAACFGRGSEYPQRVVDTATTAGMRPV
Rv0271c|M.tuberculosis_H37Rv QVHGGIGFTWEHDTNVYYRRALMLAACFGRGSEYPQRVVDTATTAGMRPV
MAB_4336|M.abscessus_ATCC_1997 QVHGGIGYTWEHDAHIYYRRALGLTAALGRSGGAPATVVRTAVEHGLRKV
MLBr_00737|M.leprae_Br4923 QLFGGAGYTSDFPVERFMRDAKITQIYEGTNQIQRVVMSRALLR------
* *. * * :. * * :
MMAR_3512|M.marinum_M WGLITG--------------------------------------------
MUL_2756|M.ulcerans_Agy99 WGLITG--------------------------------------------
MSMEG_2878|M.smegmatis_MC2_155 WELITS--------------------------------------------
Mflv_5167|M.gilvum_PYR-GCK WPLITA--------------------------------------------
Mvan_2875|M.vanbaalenii_PYR-1 WGLITG--------------------------------------------
MAV_2553|M.avium_104 WSLVTGDPPEVKTMVNKENW------------------------------
TH_4629|M.thermoresistible__bu WDLVIGNV------------------------------------------
Mb0277c|M.bovis_AF2122/97 DIDLDPSTEKLRAQIRAEVAALKAMPREPRTVAIAEGGWVLPYLPKPWGR
Rv0271c|M.tuberculosis_H37Rv DIDLDPSTEKLRAQIRAEVAALKAMPREPRTVAIAEGGWVLPYLPKPWGR
MAB_4336|M.abscessus_ATCC_1997 DIDLAPETEALRAEIRAEVAALKEIPSGKRNTAIAEGGWVLPYLPTPWGR
MLBr_00737|M.leprae_Br4923 --------------------------------------------------
MMAR_3512|M.marinum_M --------------------------------------------------
MUL_2756|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_2878|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_5167|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2875|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_2553|M.avium_104 --------------------------------------------------
TH_4629|M.thermoresistible__bu --------------------------------------------------
Mb0277c|M.bovis_AF2122/97 AASPVEQIIIAQEFTAGRVKRPQIAIATWIVPSIVAFGTDNQKQRLLPPT
Rv0271c|M.tuberculosis_H37Rv AASPVEQIIIAQEFTAGRVKRPQIAIATWIVPSIVAFGTDNQKQRLLPPT
MAB_4336|M.abscessus_ATCC_1997 AASPVEQVIISQEFLTGKVRRPQLGIATWLVPSIVAYGTEEQKQRFLPPT
MLBr_00737|M.leprae_Br4923 --------------------------------------------------
MMAR_3512|M.marinum_M --------------------------------------------------
MUL_2756|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_2878|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_5167|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2875|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_2553|M.avium_104 --------------------------------------------------
TH_4629|M.thermoresistible__bu --------------------------------------------------
Mb0277c|M.bovis_AF2122/97 FRGDIFWCQLFSEPGAGSDLASLATKATRVDGGWRITGQKIWTTGAQYSQ
Rv0271c|M.tuberculosis_H37Rv FRGDIFWCQLFSEPGAGSDLASLATKATRVDGGWRITGQKIWTTGAQYSQ
MAB_4336|M.abscessus_ATCC_1997 FRGEMMWCQLFSEPGAGSDLAGLSTKAVKVEGGWRLTGQKIWTSVAQFAD
MLBr_00737|M.leprae_Br4923 --------------------------------------------------
MMAR_3512|M.marinum_M --------------------------------------------------
MUL_2756|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_2878|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_5167|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2875|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_2553|M.avium_104 --------------------------------------------------
TH_4629|M.thermoresistible__bu --------------------------------------------------
Mb0277c|M.bovis_AF2122/97 WGALLARTDPSAPKHNGITYFLLDMKSEGVQVKPLRELTGKEFFNTVYLD
Rv0271c|M.tuberculosis_H37Rv WGALLARTDPSAPKHNGITYFLLDMKSEGVQVKPLRELTGKEFFNTVYLD
MAB_4336|M.abscessus_ATCC_1997 WGACLARTDPSAPKHNGITYFLVDMKSEGVTVRPLREMTGGALFNEVFID
MLBr_00737|M.leprae_Br4923 --------------------------------------------------
MMAR_3512|M.marinum_M --------------------------------------------------
MUL_2756|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_2878|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_5167|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2875|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_2553|M.avium_104 --------------------------------------------------
TH_4629|M.thermoresistible__bu --------------------------------------------------
Mb0277c|M.bovis_AF2122/97 DVFVPDELVLGEVNRGWEVSRNTLTAERVSIGGSDSTFLPTLGEFVDFVR
Rv0271c|M.tuberculosis_H37Rv DVFVPDELVLGEVNRGWEVSRNTLTAERVSIGGSDSTFLPTLGEFVDFVR
MAB_4336|M.abscessus_ATCC_1997 DVFVPDELVVGEVNRGWEVSRNTLTAERVSIGSSDLPFLASLDDLVAFVG
MLBr_00737|M.leprae_Br4923 --------------------------------------------------
MMAR_3512|M.marinum_M --------------------------------------------------
MUL_2756|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_2878|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_5167|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2875|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_2553|M.avium_104 --------------------------------------------------
TH_4629|M.thermoresistible__bu --------------------------------------------------
Mb0277c|M.bovis_AF2122/97 DYRFEGQFDQVARHRAGQLIAEGHATKLLNLRSTLLTLAGGDPMAPAAIS
Rv0271c|M.tuberculosis_H37Rv DYRFEGQFDQVARHRAGQLIAEGHATKLLNLRSTLLTLAGGDPMAPAAIS
MAB_4336|M.abscessus_ATCC_1997 THDLG----EVARDRAGQLIAEGHGVKLLNLRSTLLTLAGGDPMPSAAVS
MLBr_00737|M.leprae_Br4923 --------------------------------------------------
MMAR_3512|M.marinum_M --------------------------------------------------
MUL_2756|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_2878|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_5167|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2875|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_2553|M.avium_104 --------------------------------------------------
TH_4629|M.thermoresistible__bu --------------------------------------------------
Mb0277c|M.bovis_AF2122/97 KLLSMRTGQGYAEFAVSSFGTDAVIGDTERLPGKWGEYLLASRATTIYGG
Rv0271c|M.tuberculosis_H37Rv KLLSMRTGQGYAEFAVSSFGTDAVIGDTERLPGKWGEYLLASRATTIYGG
MAB_4336|M.abscessus_ATCC_1997 KLLGMRTGQGYAEFVVNHFGQDGAIGDSEQEQGRWADYLLASRATTIYGG
MLBr_00737|M.leprae_Br4923 --------------------------------------------------
MMAR_3512|M.marinum_M --------------------
MUL_2756|M.ulcerans_Agy99 --------------------
MSMEG_2878|M.smegmatis_MC2_155 --------------------
Mflv_5167|M.gilvum_PYR-GCK --------------------
Mvan_2875|M.vanbaalenii_PYR-1 --------------------
MAV_2553|M.avium_104 --------------------
TH_4629|M.thermoresistible__bu --------------------
Mb0277c|M.bovis_AF2122/97 TSEVQLNIIAERLLGLPRDP
Rv0271c|M.tuberculosis_H37Rv TSEVQLNIIAERLLGLPRDP
MAB_4336|M.abscessus_ATCC_1997 TSEVQLNIIAERLLGLPRDP
MLBr_00737|M.leprae_Br4923 --------------------