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VTAPQVDPALAEMMDAVFAEHGRDGDLWSRLDGLGLVRLTGAEESGGSGAGWHEAAELLSAAVRHGVRMP LAENDLLASWVLDAAGIGYDAALRTVCLLDERGNADAVPWASHADRIVVVWPRGGGYLAADVVADSVTIA PGVNMIGEPRDDVTADVGALRGIDIGTELVAQLALKSALTRAIQVCAALDRALELSIEHTTSREQFGRPL AKFQAVQHLISDIAAEAALARSATEAALAAAVASDWSSPQLEFLVAAARSCAGHAASVVVRNAHQVHGAI GTTSEHRLHEYTRAALAWRSEFGSVRHWDARLTDMAMQAGPHRLWELICP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_3918 | - | - | 100% (330) | acyl-CoA dehydrogenase domain-containing protein |
| M. vanbaalenii PYR-1 | Mvan_2875 | - | e-113 | 62.69% (335) | acyl-CoA dehydrogenase domain-containing protein |
| M. vanbaalenii PYR-1 | Mvan_5289 | - | 1e-18 | 30.42% (309) | acyl-CoA dehydrogenase domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3604c | fadE34 | 5e-20 | 27.83% (345) | acyl-CoA dehydrogenase FADE34 |
| M. gilvum PYR-GCK | Mflv_5167 | - | 1e-114 | 62.65% (340) | acyl-CoA dehydrogenase domain-containing protein |
| M. tuberculosis H37Rv | Rv3573c | fadE34 | 5e-20 | 27.83% (345) | acyl-CoA dehydrogenase FADE34 |
| M. leprae Br4923 | MLBr_00737 | fadE25 | 3e-11 | 25.84% (267) | putative acyl-CoA dehydrogenase |
| M. abscessus ATCC 19977 | MAB_0580 | - | 1e-16 | 27.36% (318) | acyl-CoA dehydrogenase FadE |
| M. marinum M | MMAR_3512 | - | 1e-120 | 66.17% (337) | acyl-CoA dehydrogenase |
| M. avium 104 | MAV_1813 | - | 2e-48 | 36.86% (312) | putative acyl-CoA dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_2878 | - | 1e-116 | 66.67% (330) | putative acyl-CoA dehydrogenase |
| M. thermoresistible (build 8) | TH_4629 | - | 2e-52 | 37.86% (309) | PUTATIVE putative acyl-CoA dehydrogenase |
| M. ulcerans Agy99 | MUL_2756 | - | 1e-118 | 64.99% (337) | acyl-CoA dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3604c|M.bovis_AF2122/97 ----------MVATVTDEQSAARELVRGWARTAASGAAATAAVRDMEYGF
Rv3573c|M.tuberculosis_H37Rv ----------MVATVTDEQSAARELVRGWARTAASGAAATAAVRDMEYGF
MAB_0580|M.abscessus_ATCC_1997 ---MSVPSGLRASGSSEVQEAARDAVRQWAR----SAAVIESVRKMES--
MMAR_3512|M.marinum_M ----------MSATVHTVDPALVDMME----------AVFAQYRTSH--P
MUL_2756|M.ulcerans_Agy99 ----------MSATVHTVDPALVNMME----------AVFAQYRTSH--P
MSMEG_2878|M.smegmatis_MC2_155 ---------------MTVDAELVAMMN----------AVFADHRTAH--G
Mflv_5167|M.gilvum_PYR-GCK -----------MTGPTSVDPDLVEMLD----------AVFADHREQLG-A
Mvan_3918|M.vanbaalenii_PYR-1 ------------MTAPQVDPALAEMMD----------AVFAEHGRDG---
MAV_1813|M.avium_104 -MSALAGGVFASGTVEDDGAELRQLVD----------DIGRRSFDAKLGR
TH_4629|M.thermoresistible__bu --------VFATDTA-DDYTDLRQLVD----------DIGRRSFDARIGT
MLBr_00737|M.leprae_Br4923 MVGWSGNPLFDLFKLPEEHNELRATIR----------ALAEKEIAPHAAD
:
Mb3604c|M.bovis_AF2122/97 EEGNADAWRPVFAGLAGLGLFGVAVPEDCGGAGGSIEDLCAMVDEAARAL
Rv3573c|M.tuberculosis_H37Rv EEGNADAWRPVFAGLAGLGLFGVAVPEDCGGAGGSIEDLCAMVDEAARAL
MAB_0580|M.abscessus_ATCC_1997 ---EPDGWGPAYVGLAELGIFGVAVPEAAGGSGAGFDDMIAMVDEAAASL
MMAR_3512|M.marinum_M PTEASRRDPALWQRLEQLGLARLTGAEDSGGSGASWYEAAELLAAAVRNA
MUL_2756|M.ulcerans_Agy99 PTEASRRDPALWQRLEQLGLARLTGAEDSGGSGASWYEAAELLAAAVRNA
MSMEG_2878|M.smegmatis_MC2_155 PTAG----PELWDQLRALGLARLTGAEESGGSGAGWHEAAELMAAAVRSG
Mflv_5167|M.gilvum_PYR-GCK QRPAATWDAGLWDRLGQLGLTRLTGSEESGGSGAGWREGAELLRAAVQNG
Mvan_3918|M.vanbaalenii_PYR-1 ---------DLWSRLDGLGLVRLTGAEESGGSGAGWHEAAELLSAAVRHG
MAV_1813|M.avium_104 RRVPDEFDADLWRNLEDTGLARLTSTPD---LDAGPHELAIVLYGLARHA
TH_4629|M.thermoresistible__bu RRVPDQFDDELWGNLSDTGLTRLTSDPD---LGAGPNELAVVLSGIARYA
MLBr_00737|M.leprae_Br4923 VDQRARFPEEALAALNASGFNAIHVPEEYGGQGADSVAACIVIEEVARVD
* *: : ... :: .
Mb3604c|M.bovis_AF2122/97 VPGPVATTAVATLVVSDP---------KLRSALASGERFAGVAIDGGVQV
Rv3573c|M.tuberculosis_H37Rv VPGPVATTAVATLVVSDP---------KLRSALASGERFAGVAIDGGVQV
MAB_0580|M.abscessus_ATCC_1997 VPGPVATSALVAVVLAADGH------EELVPPLAAGERTAGLALTGNLAI
MMAR_3512|M.marinum_M VRIPLAEHDLLACWLLDA------------HDMGADAAVRTVCLLDA---
MUL_2756|M.ulcerans_Agy99 VRIPLAEHDLLACWLLDS------------HDMGADAAVRTVCLLDA---
MSMEG_2878|M.smegmatis_MC2_155 VRVGLPEHDLLACWLLEV------------AGIAVDDNTRTVALLDE---
Mflv_5167|M.gilvum_PYR-GCK VQVPLAEHDLLACWLLES------------AGLPVDDARRTVCVLD----
Mvan_3918|M.vanbaalenii_PYR-1 VRMPLAENDLLASWVLDA------------AGIGYDAALRTVCLLDE---
MAV_1813|M.avium_104 GAVPLAETDALAGWLGRE------------AGIELPNGPLTVAIADSDLA
TH_4629|M.thermoresistible__bu GAVPLAETDALAGWLGRE------------AGLDLPDGPLTVAIAEHSGD
MLBr_00737|M.leprae_Br4923 ASASLIPAVNKLGTMGLILRGSEELKKQVLPSLAAEGAMASYALSEREAG
: : : .:
Mb3604c|M.bovis_AF2122/97 DPKTSTASGTVG------------RVLGGAP----GGVVLLPADGNWL--
Rv3573c|M.tuberculosis_H37Rv DPKTSTASGTVG------------RVLGGAP----GGVVLLPADGNWL--
MAB_0580|M.abscessus_ATCC_1997 ADG--LASGVLP------------AVLGGTA----DGVLLAPVPDGWV--
MMAR_3512|M.marinum_M ----DGVATEVP------------WASHADR----IVVIRQS-AGEYH--
MUL_2756|M.ulcerans_Agy99 ----DGVATEVP------------WASRADR----IVVIRQS-AGEYR--
MSMEG_2878|M.smegmatis_MC2_155 ----SGTATAVP------------WASTAQR----IVLVWRTQTGEHR--
Mflv_5167|M.gilvum_PYR-GCK ----DGVAHGVP------------WASEADR----IVVVWRT-NGTAQ--
Mvan_3918|M.vanbaalenii_PYR-1 ----RGNADAVP------------WASHADR----IVVVWPR-GGGYL--
MAV_1813|M.avium_104 GGRLTGTAMDVP------------WSGAATA----VLLAARG-RDGSR--
TH_4629|M.thermoresistible__bu G---PVKAVDVP------------WARAAAA----VLLAVRT-PDGAR--
MLBr_00737|M.leprae_Br4923 SDAASMRTRAKADGDDWILNGFKCWITNGGKSTWYTVMAVTDPDKGANGI
: . :
Mb3604c|M.bovis_AF2122/97 ---LVDTACDEVVVEPLR--ATDFSLPLARMVLTSAPVTVLEVSGE----
Rv3573c|M.tuberculosis_H37Rv ---LVDTACDEVVVEPLR--ATDFSLPLARMVLTSAPVTVLEVSGE----
MAB_0580|M.abscessus_ATCC_1997 ---LVDCAEAGVAVEAKK--ATDFSRPWVTVTLHGAAVRPVGLPAA----
MMAR_3512|M.marinum_M ---LADVDAQTLTITPG---ANMIGEPRNTVRADHLDLRGVPTTGA----
MUL_2756|M.ulcerans_Agy99 ---LADVDAQTLTITPG---ANMIGEPRNTVRADHLDLRGVPTAGA----
MSMEG_2878|M.smegmatis_MC2_155 ---VADVDAAAVRITAG---ANMIGEPRDTVSAD-VPADGATVSEA----
Mflv_5167|M.gilvum_PYR-GCK ---VADVAAGDLAVTSG---ANLAGEPRDTVAADPAALTGTTVPNA----
Mvan_3918|M.vanbaalenii_PYR-1 ---AADVVADSVTIAPG---VNMIGEPRDDVTADVGALRGIDIGTE----
MAV_1813|M.avium_104 ---VCVLDGGETSADDG---YNLAGEPRGRLTFDVAADELTPVDDA----
TH_4629|M.thermoresistible__bu ---IGITS--NPQVVDG---HNAAGEPRGRVTVDLGAVTLASVDDA----
MLBr_00737|M.leprae_Br4923 SAFIVHKDDEGFSIGPKEKKLGIKGSPTTELYFDKCRIPGDRIIGEPGTG
. * :
Mb3604c|M.bovis_AF2122/97 --RVEDLA---ATVLAAEAAGVARWTLDTAVAYAKVREQFGKPIGSFQAV
Rv3573c|M.tuberculosis_H37Rv --RVEDLA---ATVLAAEAAGVARWTLDTAVAYAKVREQFGKPIGSFQAV
MAB_0580|M.abscessus_ATCC_1997 --VIADLS---VVTLSAEAVGVARWALQTAVEYAKVREQFGKQIGSFQAI
MMAR_3512|M.marinum_M --VVSTLKFKSALVRAIQVCAALDQILHLSVEHVSSRVQFGRPLAKFQAV
MUL_2756|M.ulcerans_Agy99 --VVSTLKFKSALVRAIQVCAALDQILHLSVEHVSSRVQFGRPLAKFHAV
MSMEG_2878|M.smegmatis_MC2_155 --TVTTLHLKAALVRAVQVCAAMDTILELAVEHSSSRIQFGRPLAKFQAI
Mflv_5167|M.gilvum_PYR-GCK --LIDQLLLRGALVRGLQVCAALDRIVALSIAHTTDRTQFGRPLAKFQSV
Mvan_3918|M.vanbaalenii_PYR-1 --LVAQLALKSALTRAIQVCAALDRALELSIEHTTSREQFGRPLAKFQAV
MAV_1813|M.avium_104 --VADELSRRGGWCRCIQIVGALDAAAALTVAHTRERVQFGRPLSAFQAV
TH_4629|M.thermoresistible__bu --VLTELTLRGAWCRAVQIVGALDTAAAMTVRHTAEREQFGRSLSKFQAV
MLBr_00737|M.leprae_Br4923 FKTALATLDHTRPTIGAQAVGIAQGALDAAIVYTKDRKQFGESISTFQSI
: . :: : * ***. :. *:::
Mb3604c|M.bovis_AF2122/97 KHLCAQMLCRAEQADVAAADAARAAAD-----SDGTQLSIAAAVAASIGI
Rv3573c|M.tuberculosis_H37Rv KHLCAQMLCRAEQADVAAADAARAAAD-----SDGTQLSIAAAVAASIGI
MAB_0580|M.abscessus_ATCC_1997 KHMCAEMLCRVEQADVAVWDAAGCAQDVLANKGDSQQLSLAAAVAAAVAV
MMAR_3512|M.marinum_M QNLIADIAAETALARAATEAALTKAVTS---QWSAQNLDFLVAVARSCVG
MUL_2756|M.ulcerans_Agy99 QNLIADIAAETALARAATEAALTKAVTS---QWSAQNLDFLVAVARSCVG
MSMEG_2878|M.smegmatis_MC2_155 QHMISDIAAEATLARTATEAALTAAVDT---TWSAPHLEFLVAVARSCCG
Mflv_5167|M.gilvum_PYR-GCK QNLVSDSAAEAALARAATEAALTEAVRT---GWSGTNLEFLVAVARSCTG
Mvan_3918|M.vanbaalenii_PYR-1 QHLISDIAAEAALARSATEAALAAAVAS---DWSSPQLEFLVAAARSCAG
MAV_1813|M.avium_104 QQSLAGMAGEIERARAAVELAVAAAAEH---GFGSPHTDYAVTVAKVAVG
TH_4629|M.thermoresistible__bu QHALAGMAGEIERARAAASLAVAAAADY---GFAAPRTEFAITAARVTAG
MLBr_00737|M.leprae_Br4923 QFMLADMAMKVEAARLIVYAAAARAERG------EPDLGFISAASKCFAS
: : . * . * * :.:
Mb3604c|M.bovis_AF2122/97 DAAKANAKDCIQVLGGIGCTWEHDAHLYLRRAHGIGGFLGGSGRWLRRVT
Rv3573c|M.tuberculosis_H37Rv DAAKANAKDCIQVLGGIGCTWEHDAHLYLRRAHGIGGFLGGSGRWLRRVT
MAB_0580|M.abscessus_ATCC_1997 DAAVANTKDCIQILGGIGFTWEHDAHLYLRRAYALQSFVGKPAVWRRKAA
MMAR_3512|M.marinum_M HAVSVVVRNAHQVHGAIGTTEEHRLHEFTRAALAWRSEFGSVHYWDEQVT
MUL_2756|M.ulcerans_Agy99 HVVSVVVRNAHQVHGAIGTTEEHRLHEFTRAALAWRSEFGSVHYWDEQVT
MSMEG_2878|M.smegmatis_MC2_155 HAASVVVRNAHQVFGAIGTTAEHRLHEYTRAALAWRGEFGSVRSWDERVT
Mflv_5167|M.gilvum_PYR-GCK HATSVVVRNAHQVHGAIGTTREHRLHEFTQPALAWRSEFGSVHYWDELLT
Mvan_3918|M.vanbaalenii_PYR-1 HAASVVVRNAHQVHGAIGTTSEHRLHEYTRAALAWRSEFGSVRHWDARLT
MAV_1813|M.avium_104 RAVIPVTTTAHQLHGAIGVTSEHPLWLFTLRAQSWADDYGTTAHHARRLG
TH_4629|M.thermoresistible__bu RAVTAVTTSAHQLHGAIGVTAEHPLWSVTLRAQAWADEFGTTAGYARRLG
MLBr_00737|M.leprae_Br4923 DIAMEVTTDAVQLFGGAGYTSDFPVERFMRDAKITQIYEGTNQIQRVVMS
. . . *: *. * * :. * *
Mb3604c|M.bovis_AF2122/97 ALTQAGVRRRLGVDLAEVAGLRPEIAAAVAEVAALPEEKRQVALADTGLL
Rv3573c|M.tuberculosis_H37Rv ALTQAGVRRRLGVDLAEVAGLRPEIAAAVAEVAALPEEKRQVALADTGLL
MAB_0580|M.abscessus_ATCC_1997 ALTIGGIRRSLTIDLGEVESQRAEVAGQVAEIASAPKAEHQVRLAEAGFL
MMAR_3512|M.marinum_M --------------------------------------------------
MUL_2756|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_2878|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_5167|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3918|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_1813|M.avium_104 --------------------------------------------------
TH_4629|M.thermoresistible__bu --------------------------------------------------
MLBr_00737|M.leprae_Br4923 --------------------------------------------------
Mb3604c|M.bovis_AF2122/97 APHWPAPYGRGASPAEQLLIDQELAAAKVERPDLVIGWWAAPTILEHGTP
Rv3573c|M.tuberculosis_H37Rv APHWPAPYGRGASPAEQLLIDQELAAAKVERPDLVIGWWAAPTILEHGTP
MAB_0580|M.abscessus_ATCC_1997 APHWPAPYGLGAGAAQQLLIDQELHAAGVNRPDLVIGWWAAPTILEHGTP
MMAR_3512|M.marinum_M --------------------KAALHAGGSGLWGLITG-------------
MUL_2756|M.ulcerans_Agy99 --------------------KAALHAGGSGLWGLITG-------------
MSMEG_2878|M.smegmatis_MC2_155 --------------------TAALQAGGAGLWELITS-------------
Mflv_5167|M.gilvum_PYR-GCK --------------------TAALAAGRDGLWPLITA-------------
Mvan_3918|M.vanbaalenii_PYR-1 --------------------DMAMQAGPHRLWELICP-------------
MAV_1813|M.avium_104 --------------------RMALAAGDP--WDLVIGNLTRPKTVDK---
TH_4629|M.thermoresistible__bu --------------------RLALESANP--WDLVIGNV-----------
MLBr_00737|M.leprae_Br4923 --------------------RALLR-------------------------
:
Mb3604c|M.bovis_AF2122/97 EQIERFVPATMRGEFLWCQLFSEPGAGSDLASLRTKAVRADGGWLLTGQK
Rv3573c|M.tuberculosis_H37Rv EQIERFVPATMRGEFLWCQLFSEPGAGSDLASLRTKAVRADGGWLLTGQK
MAB_0580|M.abscessus_ATCC_1997 EQIAQFVAPTLRGEIEWCQLFSEPGAGSDLAALRTKATRVDGGWKLDGQK
MMAR_3512|M.marinum_M --------------------------------------------------
MUL_2756|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_2878|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_5167|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3918|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_1813|M.avium_104 --------------------------------------------------
TH_4629|M.thermoresistible__bu --------------------------------------------------
MLBr_00737|M.leprae_Br4923 --------------------------------------------------
Mb3604c|M.bovis_AF2122/97 VWTSAAHKARWGVCLARTDPDAPKHKGITYFLVDMTTPGIEIRPLREITG
Rv3573c|M.tuberculosis_H37Rv VWTSAAHKARWGVCLARTDPDAPKHKGITYFLVDMTTPGIEIRPLREITG
MAB_0580|M.abscessus_ATCC_1997 VWNSKAQIADWAICLARTNPDVPKHKGITYFLLDMKTPGITVRPLREITG
MMAR_3512|M.marinum_M --------------------------------------------------
MUL_2756|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_2878|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_5167|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3918|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_1813|M.avium_104 --------------------------------------------------
TH_4629|M.thermoresistible__bu --------------------------------------------------
MLBr_00737|M.leprae_Br4923 --------------------------------------------------
Mb3604c|M.bovis_AF2122/97 DSLFNEVFLDNVFVPDEMVVGAVNDGWRLARTTLANERVAMATGTALGNP
Rv3573c|M.tuberculosis_H37Rv DSLFNEVFLDNVFVPDEMVVGAVNDGWRLARTTLANERVAMATGTALGNP
MAB_0580|M.abscessus_ATCC_1997 EEMFNEVFLDGVIVPDENVVGSVDDGWRLARTTLANERVAMAGGGTLDEA
MMAR_3512|M.marinum_M --------------------------------------------------
MUL_2756|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_2878|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_5167|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3918|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_1813|M.avium_104 --------------------------------------------------
TH_4629|M.thermoresistible__bu --------------------------------------------------
MLBr_00737|M.leprae_Br4923 --------------------------------------------------
Mb3604c|M.bovis_AF2122/97 MEELLKVLGDMELDVAQQDRLGRLILLAQAGALLDRRIAELAVGGQDPGA
Rv3573c|M.tuberculosis_H37Rv MEELLKVLGDMELDVAQQDRLGRLILLAQAGALLDRRIAELAVGGQDPGA
MAB_0580|M.abscessus_ATCC_1997 MESLLALIGDTELDAAQLDTLGAFVCSAQTGALLDLRTALRAIGGQDPGA
MMAR_3512|M.marinum_M --------------------------------------------------
MUL_2756|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_2878|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_5167|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3918|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_1813|M.avium_104 --------------------------------------------------
TH_4629|M.thermoresistible__bu --------------------------------------------------
MLBr_00737|M.leprae_Br4923 --------------------------------------------------
Mb3604c|M.bovis_AF2122/97 QSSVRKLIGVRYRQALAEYLMEVSDGGGLVENRAVYDFLNTRCLTIAGGT
Rv3573c|M.tuberculosis_H37Rv QSSVRKLIGVRYRQALAEYLMEVSDGGGLVENRAVYDFLNTRCLTIAGGT
MAB_0580|M.abscessus_ATCC_1997 ASSVRKLVGVRHRQGLSEHILDYVDTHGAVESREMWLFMRDRCLSIAGGT
MMAR_3512|M.marinum_M --------------------------------------------------
MUL_2756|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_2878|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_5167|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3918|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_1813|M.avium_104 --------------------------------------------------
TH_4629|M.thermoresistible__bu --------------------------------------------------
MLBr_00737|M.leprae_Br4923 --------------------------------------------------
Mb3604c|M.bovis_AF2122/97 EQILLTVAAERLLGLPR
Rv3573c|M.tuberculosis_H37Rv EQILLTVAAERLLGLPR
MAB_0580|M.abscessus_ATCC_1997 TQILLSVAGERLLGLPR
MMAR_3512|M.marinum_M -----------------
MUL_2756|M.ulcerans_Agy99 -----------------
MSMEG_2878|M.smegmatis_MC2_155 -----------------
Mflv_5167|M.gilvum_PYR-GCK -----------------
Mvan_3918|M.vanbaalenii_PYR-1 -----------------
MAV_1813|M.avium_104 -----------------
TH_4629|M.thermoresistible__bu -----------------
MLBr_00737|M.leprae_Br4923 -----------------