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MDLRIAGRTALVTASSQGLGRACASALIAEGVSVVINGRETDKLERAAAEIGALATHGASCRFVTADLTT DTGVQAIFDQVDQLDILVTNNRGPRPADIIGVTDDDLAESLRLHYYVPIHLVQRYLPGMRDRRFGRIVNI TSEMVESPVAGMIASAGARSALTTAMKGVQHDSVADNVTINQLLPMLIDSPRQLQMAQLLSESSGVAFEE IRRRQASVTSAKRLGRPEEVGAACAFLCSEQAGYISGVSLPVNGGGPVMGGGA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_3383 | - | - | 100% (263) | FabG-like dehydrogenase |
| M. marinum M | MMAR_4715 | - | 8e-21 | 29.84% (248) | 3-oxoacyl- |
| M. marinum M | MMAR_0629 | - | 5e-18 | 27.24% (257) | dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1570 | - | 3e-19 | 28.87% (194) | fatty acyl-CoA reductase |
| M. gilvum PYR-GCK | Mflv_0296 | - | 2e-28 | 33.58% (268) | short-chain dehydrogenase/reductase SDR |
| M. tuberculosis H37Rv | Rv1543 | - | 3e-19 | 28.87% (194) | fatty acyl-CoA reductase |
| M. leprae Br4923 | MLBr_01807 | fabG1 | 6e-15 | 25.40% (252) | 3-oxoacyl- |
| M. abscessus ATCC 19977 | MAB_2032 | - | 2e-20 | 28.52% (256) | 3-oxoacyl- |
| M. avium 104 | MAV_2549 | - | 1e-25 | 33.33% (264) | short-chain dehydrogenase/reductase SDR |
| M. smegmatis MC2 155 | MSMEG_1157 | - | 1e-34 | 35.52% (259) | short chain dehydrogenase |
| M. thermoresistible (build 8) | TH_3893 | - | 3e-21 | 25.56% (266) | PUTATIVE putative short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_0315 | fabG2 | 5e-20 | 29.55% (247) | 3-oxoacyl- |
| M. vanbaalenii PYR-1 | Mvan_0045 | - | 2e-25 | 31.42% (261) | short-chain dehydrogenase/reductase SDR |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_3383|M.marinum_M ----------------------------------------------MDLR
MSMEG_1157|M.smegmatis_MC2_155 ----------------------------------------------MDLK
MAV_2549|M.avium_104 ----------------------------------------------MHYG
MLBr_01807|M.leprae_Br4923 --------------------------------MTDAAAKVSAAPGRGKPA
MUL_0315|M.ulcerans_Agy99 -----------------------------------------MRPD-SSPS
Mvan_0045|M.vanbaalenii_PYR-1 ----------------------------------------------MSTD
Mflv_0296|M.gilvum_PYR-GCK ----------------------------------------------MDMG
TH_3893|M.thermoresistible__bu ----------------------------------------------MDFD
MAB_2032|M.abscessus_ATCC_1997 ---------------------------------------------MSGKE
Mb1570|M.bovis_AF2122/97 MNLGDLTNFVEKPLAAVSNIVNTPNSAGRYRPFYLRNLLDAVQGRNLNDA
Rv1543|M.tuberculosis_H37Rv MNLGDLTNFVEKPLAAVSNIVNTPNSAGRYRPFYLRNLLDAVQGRNLNDA
MMAR_3383|M.marinum_M IAGRTALVTASSQGLGRACASALIAEGVSVVINGRETDKLERAAAEIGAL
MSMEG_1157|M.smegmatis_MC2_155 IKDRVALVLASTAGLGAATARALAAEGAHVVITGRNAERAERLAASLPSA
MAV_2549|M.avium_104 IDGRSALVVGGSKGIGFEVAKLLAAEGARVAILARTKTDVDAAVEAIRTE
MLBr_01807|M.leprae_Br4923 FVSRSILVTGGNRGIGLAVARRLVADGHRVAVTHRAS-------VVPDWF
MUL_0315|M.ulcerans_Agy99 WCTITSVVTGGASGIGLAIARRLSADGTDVATLDLK---------TPDGG
Mvan_0045|M.vanbaalenii_PYR-1 LRGRVALVTGAARGMGAAHARRLAAAGATVAVNDREDSDALTALATEIGG
Mflv_0296|M.gilvum_PYR-GCK LSGKRALVTGSSSGLGRAIAESLAAEGASVVVHGRDE-VRTGAVADGIRA
TH_3893|M.thermoresistible__bu LNGKRALVTGSSSGIGAGIVETLAAEGVSVVVHGRNA-ERAEAVADRIRA
MAB_2032|M.abscessus_ATCC_1997 FEGQVALVTGASRGIGRSIALALAEHGADIALHYGNSKPAAEEVAEKISA
Mb1570|M.bovis_AF2122/97 VKGKVVLITGGSSGIGAAAAKKIAEAGGTVVLVARTLENLENVANDIRAI
Rv1543|M.tuberculosis_H37Rv VKGKVVLITGGSSGIGAAAAKKIAEAGGTVVLVARTLENLENVANDIRAI
:: .. *:* . : * :.
MMAR_3383|M.marinum_M AT--HGASC-R-FVTADLTTDTGVQAIFDQVDQLDILVTNNRGPRPA---
MSMEG_1157|M.smegmatis_MC2_155 TA--VPVD-----LTEPRAVEHLLTATREAYGEPDIVVLNGPGPKPG---
MAV_2549|M.avium_104 GG--TAIGVTA-DVADDGQLTDAVREIAARHGAPLIVVGQAKYQRPG---
MLBr_01807|M.leprae_Br4923 FG--VECD-----VTDNDAIGAAFKAVEEHQGPVEVLVANAGITSDM---
MUL_0315|M.ulcerans_Agy99 LA--FSAD-----VTNRSQVDAALAAIRQRLGPVTILVNAAGLDGFK---
Mvan_0045|M.vanbaalenii_PYR-1 LT--APGD-----VSDPKSCRALATHVAATTGRLDVLVANHAYMTMA---
Mflv_0296|M.gilvum_PYR-GCK RG--GDAWAAVGDLATEGGAGAVAAAAG----EVDILVNNAGVYDG---L
TH_3893|M.thermoresistible__bu DG--GTAATAVGDLATEDGAAQVADTAAAAFSGIDILVNNAGGSSETGIQ
MAB_2032|M.abscessus_ATCC_1997 LG--RRVLLCQGDIADPAVPELLADTVHAEFGRIDVLVNNAGTHGAG---
Mb1570|M.bovis_AF2122/97 RGNGGTAHVYPCDLSDMDAIAVMADQVLGDLGGVDILINNAGRSIRR---
Rv1543|M.tuberculosis_H37Rv RGNGGTAHVYPCDLSDMDAIAVMADQVLGDLGGVDILINNAGRSIRR---
:: :::
MMAR_3383|M.marinum_M DIIGVTDDDLA---ESLRLHYYVPIHLVQRYLPGMRDRRFGRIVNITSEM
MSMEG_1157|M.smegmatis_MC2_155 AAADLDAEDID---TIGDLLLKTHVRLVKAVLPHMRAQGWGRILAIGSSG
MAV_2549|M.avium_104 DFADITDVNVYR--ESFELHTMSQILLLHAVLPAMQDAGWGRFVHIGSAT
MLBr_01807|M.leprae_Br4923 LIMRMSEEQFQ---KVIDVNLTGVFRVAKLASRNMIKQRFGRYIFMGSVV
MUL_0315|M.ulcerans_Agy99 RFSNITFEDWQ---RVIDVNLNGVFHTIQAVLPDMVAAGWGRIVNISSSS
Mvan_0045|M.vanbaalenii_PYR-1 PLLEHADDDWW---KVVDTNLGGTFFLVQSVLPHMRRTGAGRIVVIASEW
Mflv_0296|M.gilvum_PYR-GCK AWSDLAPRQWQ---SIYEVNVVSGVRMIEYLVPGMRQRGWGRIIQIGGGL
TH_3893|M.thermoresistible__bu SWFALPVSEWG---VTYQRNVMSAGYLIHALVPAMKESGWGRIIQIASAA
MAB_2032|M.abscessus_ATCC_1997 LLLDIAPDYLE---ETVATNLLGPIRMTKAVVAHMLGQRYGRIINISSVA
Mb1570|M.bovis_AF2122/97 -SLELSYDRIHDYQRTMQLNYLGAVQLILKFIPGMRERHFGHIVNVSSVG
Rv1543|M.tuberculosis_H37Rv -SLELSYDRIHDYQRTMQLNYLGAVQLILKFIPGMRERHFGHIVNVSSVG
* *: : : .
MMAR_3383|M.marinum_M VESPVA--GMIASAGARSALTTAMKGVQHDSVADNVTINQLLPMLIDSPR
MSMEG_1157|M.smegmatis_MC2_155 VQAPIP--MLAASNIGRAGLAAYLKTLASEVAADGVTVNLQLPGRIATDR
MAV_2549|M.avium_104 AKEPAGNIHHAVANTSRPSTIGLLKTVSDEYAQFGITVNTVAPGWIETEN
MLBr_01807|M.leprae_Br4923 GLSGVP--GQANYAASKSGLIGMARSLARELGSRSITANVVAPGFIDTE-
MUL_0315|M.ulcerans_Agy99 THSGTP--YMTHYVAAKSAVNGLTKALALEYGPSGITVNAVPPGFIDTP-
Mvan_0045|M.vanbaalenii_PYR-1 GVTGWP--EATAYAAAKSGLISLVKTLGRELAREHIIVNAVAPGVIDTP-
Mflv_0296|M.gilvum_PYR-GCK ALQPAA--DQPHYNATLAARHNLTVSLARELAGTGVTSNTVAPGAILTEP
TH_3893|M.thermoresistible__bu GIIPTS--GQPDYGPSKAAMINMSMGLSKALAGTGITVNTVMPGMIMTEG
MAB_2032|M.abscessus_ATCC_1997 ADKPDS--GQSTYAATKGGLESFTKAIAVEFASRNIISNAVAPGVVYTDM
Mb1570|M.bovis_AF2122/97 VQTRAP--RFGAYIASKAALDSLCDALQAETVHDNVRFTTVHMALVRTPM
Rv1543|M.tuberculosis_H37Rv VQTRAP--RFGAYIASKAALDSLCDALQAETVHDNVRFTTVHMALVRTPM
. : : . : :
MMAR_3383|M.marinum_M QLQMAQLLSESSGVA--------FEEIRRRQASVTSAKRLGRPEEVGAAC
MSMEG_1157|M.smegmatis_MC2_155 VAALDEAAAQRQGRS--------PDEVRAASEASIPAGRYGTPDEFGALA
MAV_2549|M.avium_104 ALAYLEQHLGASTDQ--------ERREFMLREARVPAARMGKPSEIASLI
MLBr_01807|M.leprae_Br4923 ---MTRAMDSK---------------YQEAALQAIPLGRIGAVEEIAGAV
MUL_0315|M.ulcerans_Agy99 ---MLRNAAAQGHL-----------GDIEQNIARTPVRRIGKPEDIAAAC
Mvan_0045|M.vanbaalenii_PYR-1 ---QLQVDADAAGVG--------LDDIHRRYAEAIPLGRIGSADEVAVAV
Mflv_0296|M.gilvum_PYR-GCK VREMTYRVAAQRGWGPTWE-DVEKAAATTWFPN--DIGRFGRPEEVAAAV
TH_3893|M.thermoresistible__bu LRDFLRTFADHRGWG---D-DLDKAADYILKGTGQTVHRIGQVSDVAYAV
MAB_2032|M.abscessus_ATCC_1997 AEITRTHVPAT----------FERLKAQILAKD------FAKPEIVADAV
Mb1570|M.bovis_AF2122/97 ISPTTIYDKFPTLTPDQAAGVITDAIVHRPRRASSPFGQFAAVADAVNPA
Rv1543|M.tuberculosis_H37Rv ISPTTIYDKFPTLTPDQAAGVITDAIVHRPRRASSPFGQFAAVADAVNPA
.
MMAR_3383|M.marinum_M AFLCSEQAGY-ISGVSLPVNGGGPVMGGGA-----------------
MSMEG_1157|M.smegmatis_MC2_155 AFLCSSAASY-ITGTAVRCDGG---MLAHL-----------------
MAV_2549|M.avium_104 AYLCSEPAGY-LTGSWIEVDGG---LHRSAF----------------
MLBr_01807|M.leprae_Br4923 SFLASEDAGY-ISGAVIPVDGG---LGMGH-----------------
MUL_0315|M.ulcerans_Agy99 AFLVSEEAGY-ITGQILGVNGG---RNT-------------------
Mvan_0045|M.vanbaalenii_PYR-1 ELLSDFDLEA-VVGQVISCNGG---STRTRA----------------
Mflv_0296|M.gilvum_PYR-GCK AFLAGVHAGY-ISGADLRVDGG---AIRSVA----------------
TH_3893|M.thermoresistible__bu AFLASPRADF-LNGINLHLDGG---ATQSIY----------------
MAB_2032|M.abscessus_ATCC_1997 LYLASPHNTY-ITGEVLHIDGG---YKMK------------------
Mb1570|M.bovis_AF2122/97 VMDRVRNRAFNMFGDSSAAKGSESQTDTSELDKRSETFVRATRGIHW
Rv1543|M.tuberculosis_H37Rv VMDRVRNRAFNMFGDSSAAKGSESQTDTSELDKRSETFVRATRGIHW
: * .*.