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M. marinum M MMAR_1771 (drrA)

annotation: daunorubicin-DIM-transport ATP-binding protein ABC transporter DrrA
coordinates: 2143027 - 2144022
length: 331

RNNDLAVEVRGVRKAFGDVVALNDISFEVGRGEVIGLLGPNGAGKTTMVDILSTLTRPDAGSAHVAGSDV
VAQPAGVRRSIMVTGQQVAVDDGLTGEQNLVLFGRLYGLRKSRARQRAQELLDQFGLTYAGKRLVRTYSG
GMRRRIDIACGLVVEPQVAFLDEPTTGLDPRSRQAIWDLVTSFKKLGIATLLTTQYLEEADALSDRIILI
DHGKIIADGTANELKHRAGDTFCEIVPRHLKDLDATVAALGSLLPEHNRAMVTSESDRITMPAPDGTRTL
IEAARRIDEANIELADIALRRPSLDDVFLSMTTDPSEAHALSHVASGAML*
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. marinum MMMAR_1771drrA-100% (331)daunorubicin-DIM-transport ATP-binding protein ABC transporter DrrA
M. marinum MMMAR_3263-8e-6946.96% (313) ATP-binding protein ABC transporter
M. marinum MMMAR_2263-8e-4636.19% (315) antibiotic ABC transporter ATP-binding protein

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb2961drrA1e-15383.38% (331) daunorubicin-DIM-transport ATP-binding protein ABC
M. gilvum PYR-GCKMflv_3389-1e-11866.14% (319) daunorubicin resistance ABC transporter ATPase subunit
M. tuberculosis H37RvRv2936drrA1e-15283.08% (331) daunorubicin-DIM-transport ATP-binding protein ABC
M. leprae Br4923MLBr_02352-1e-15081.63% (332) putative antibiotic resistance efflux protein
M. abscessus ATCC 19977MAB_2752-2e-3935.35% (297) ABC transporter ATP-binding protein
M. avium 104MAV_3250-5e-8854.55% (308) daunorubicin resistance ATP-binding protein DrrA
M. smegmatis MC2 155MSMEG_6509-3e-4640.32% (248) ABC-type drug export system, ATP-binding protein
M. thermoresistible (build 8)TH_2745-5e-3034.39% (221) PUTATIVE ABC transporter related
M. ulcerans Agy99MUL_2014drrA0.099.09% (331) daunorubicin-DIM-transport ATP-binding protein ABC
M. vanbaalenii PYR-1Mvan_3122-1e-12068.25% (315) daunorubicin resistance ABC transporter ATPase subunit

CLUSTAL 2.0.9 multiple sequence alignment


Mflv_3389|M.gilvum_PYR-GCK          ---------MPSTDKAVVVEGIKKSFG--AVTALRDVSFDVGRGEVLGLL
Mvan_3122|M.vanbaalenii_PYR-1       ---------MTRSDKAVVVAGIKKSFG--SVQALRDVSFEVERGEVLGLL
MMAR_1771|M.marinum_M               ---------MRNNDLAVEVRGVRKAFG--DVVALNDISFEVGRGEVIGLL
MUL_2014|M.ulcerans_Agy99           ---------MRNNDLAVEVRGVRKAFG--DVVALNDISFEVGRGEVIGLL
Mb2961|M.bovis_AF2122/97            ---------MRNDDMAVVVNGVRKTYGKGKIVALDDVSFKVRRGEVIGLL
Rv2936|M.tuberculosis_H37Rv         ---------MRNDDMAVVVNGVRKTYGKGKIVALDDVSFKVRRGEVIGLL
MLBr_02352|M.leprae_Br4923          ---------MRNNDKAVMVRGVRKTYGKGKIIALDDVSFDVDRGEVIGLL
MAV_3250|M.avium_104                -----------MSAPAIEVEGLTKKFG-GSTLALAGVDFSVPAGTVCGLL
MAB_2752|M.abscessus_ATCC_1997      ---------------------------------MDSLDLEVHAAQVFALL
MSMEG_6509|M.smegmatis_MC2_155      MTDHMPEPTLPDRTPAIDCDGLTHRYG--QFTAVEDLTLQVRAGETLGLL
TH_2745|M.thermoresistible__bu      ---MTTTSPRFDAEPAVEIHGLKKSFG--RTRAVDGLDLRVERGSVAGFL
                                                                     : .: : *  . . .:*

Mflv_3389|M.gilvum_PYR-GCK          GPNGAGKTTTVNILSTLIKPDSGRAMIAGHDVVTDPAGVRRALMLTGQHA
Mvan_3122|M.vanbaalenii_PYR-1       GPNGAGKTTTVNILSTLIKPDSGRALIAGHDVVTDPAGVRRALMLTGQHA
MMAR_1771|M.marinum_M               GPNGAGKTTMVDILSTLTRPDAGSAHVAGSDVVAQPAGVRRSIMVTGQQV
MUL_2014|M.ulcerans_Agy99           GPNGAGKTTMVDILSTLTRPDAGSAHVAGYDVVAQPAGVRRSIMVTGQQV
Mb2961|M.bovis_AF2122/97            GPNGAGKTTMVDILSTLTRPDAGSAIIAGYDVVSEPAGVRRSIMVTGQQV
Rv2936|M.tuberculosis_H37Rv         GPNGAGKTTMVDILSTLTRPDAGSAIIAGYDVVSEPAGVRRSIMVTGQQV
MLBr_02352|M.leprae_Br4923          GPNGAGKTTMVDILSTLTRPDRGLATVAGYDVVSEPAGVRRSIMVTGQQV
MAV_3250|M.avium_104                GHNGAGKTTTINILSTLIRPTSGRARVAGYDVVRQPAEVRASIGMAGQFT
MAB_2752|M.abscessus_ATCC_1997      GPNGAGKTTTVELCEGFLHPDEGTVEVLGMDPVAKNSAVRSRIGVMLQGG
MSMEG_6509|M.smegmatis_MC2_155      GPNGAGKTTAVRVLTTLTPVQQGRVRIFGLDTRAHTMDIRHNIGYVPQQL
TH_2745|M.thermoresistible__bu      GPNGSGKSTTIRVLLGLLRADGGTARLLGGDPWHDAVELHRRLAYVPGDV
                                    * **:**:* : :   :     * . : * *   .   ::  :       

Mflv_3389|M.gilvum_PYR-GCK          ALDDLLTGRENLLMFGRLQGLKKKVAKQRAQELLEQFDLVGAGDRAVGNY
Mvan_3122|M.vanbaalenii_PYR-1       ALDDLLTGRENLLMFGRLQGLKKKVAKQRAQELLEQFDLVQAADRPVGTY
MMAR_1771|M.marinum_M               AVDDGLTGEQNLVLFGRLYGLRKSRARQRAQELLDQFGLTYAGKRLVRTY
MUL_2014|M.ulcerans_Agy99           AVDDGLTGEQNLVLFGRLYGLRKSRARQRAQELLDQFGLTYAGKRLVRTY
Mb2961|M.bovis_AF2122/97            AVDDALSGEQNLVLFGRLWGLSKSAARKRAAELLEQFSLVHAGKRRVGTY
Rv2936|M.tuberculosis_H37Rv         AVDDALSGEQNLVLFGRLWGLSKSAARKRAAELLEQFSLVHAGKRRVGTY
MLBr_02352|M.leprae_Br4923          AVDDQLSGEQNLILFGRLYGLSKSVARVRTQELLEQFDLLHAGKRRVGTY
MAV_3250|M.avium_104                GMDPMLTGRENLVLFGRLRGLNRRRAKARADELLEQFNLVDAADRRLSTY
MAB_2752|M.abscessus_ATCC_1997      GAYPTARASEMLGLVASYS-----ANPLDPQWLLDTLGLTDAARTPYRRL
MSMEG_6509|M.smegmatis_MC2_155      SIEAALTGRQNVELFARLYDVPRSERADRVAAALEAMQLLDVADTVAGTY
TH_2745|M.thermoresistible__bu      TLWPNLTGGQAIDFLAGLR---DNFDTKRRDELIERFELD--PDKKARTY
                                           . : : :..                 :: : *           

Mflv_3389|M.gilvum_PYR-GCK          SGGMKRRIDIACGLVVRPEVVFLDEPTTGLDPRSRQAIWELVTDFK-EAG
Mvan_3122|M.vanbaalenii_PYR-1       SGGMKRRIDIACGLVVRPEVVFLDEPTTGLDPRSRQAIWELVTDFK-EAG
MMAR_1771|M.marinum_M               SGGMRRRIDIACGLVVEPQVAFLDEPTTGLDPRSRQAIWDLVTSFK-KLG
MUL_2014|M.ulcerans_Agy99           SGGMRRRIDIACGLVVEPQVAFLDEPTTGLDPRSRQAIWDLVTSFK-KLG
Mb2961|M.bovis_AF2122/97            SGGMRRRIDIACGLVVQPQVAFLDEPTTGLDPRSRQAIWDLVASFK-KLG
Rv2936|M.tuberculosis_H37Rv         SGGMRRRIDIACGLVVQPQVAFLDEPTTGLDPRSRQAIWDLVASFK-KLG
MLBr_02352|M.leprae_Br4923          SGGMRRRIDIACGLVVQPQVAFLDEPTTGLDPRSRQAIWDLVASFK-QIG
MAV_3250|M.avium_104                SGGMYRRVDLASALVVPPKVLFLDEPTTGLDPRSRRDVWALVSSLR-VQG
MAB_2752|M.abscessus_ATCC_1997      SGGQQQRLALACALVGRPELVFLDEPTAGMDAHARLVVWELIDCLR-RDG
MSMEG_6509|M.smegmatis_MC2_155      SGGMVRRLELAQALVNRPLLLILDEPTVGLDPIARDSVWTQVRAMQAEFG
TH_2745|M.thermoresistible__bu      SKGNRQKVALVAAFSTNAEIYILDEPTSGLDPLMDKAFQMCVREAA-DNG
                                    * *  ::: :. .:   . : :***** *:*.     .   :       *

Mflv_3389|M.gilvum_PYR-GCK          IATLLTTQYLEEADLLSDRIIVIDKGTVIAEGTADQLKERTGGTYCEIVP
Mvan_3122|M.vanbaalenii_PYR-1       IATLLTTQYLEEADLLSDRIIVIDKGTVIAEGTADELKERTGGTYCEIVP
MMAR_1771|M.marinum_M               IATLLTTQYLEEADALSDRIILIDHGKIIADGTANELKHRAGDTFCEIVP
MUL_2014|M.ulcerans_Agy99           IATLLTTQYLEEADALSDRIILIDHGKIIADGTANELKHRAGDTFCEIVP
Mb2961|M.bovis_AF2122/97            IATLLTTQYLEEADALSDRIILIDHGIIIAEGTANELKHRAGDTFCEIVP
Rv2936|M.tuberculosis_H37Rv         IATLLTTQYLEEADALSDRIILIDHGIIIAEGTANELKHRAGDTFCEIVP
MLBr_02352|M.leprae_Br4923          IATLLTTQYLEEADELSDRIILIDHGTVIAEGTASELKHRVGETFCEIVP
MAV_3250|M.avium_104                ISVLLTTQYLEEADVLSDSIVVIDHGRVIASGTSEELKRAVGTSYCQVTP
MAB_2752|M.abscessus_ATCC_1997      VSVVLTTHHMKEAEELADQLMIIDHGSVVAAGTPSELMQSGAENQLRFAA
MSMEG_6509|M.smegmatis_MC2_155      MTVLLTTHYMGEADALCDRVALMHHGRLQAVGSPDELKRAVSS-------
TH_2745|M.thermoresistible__bu      AAVLLSSHILAEVERLCDSVTIIRSGRTVRAGRLDELRHLMRTTVKVRTR
                                     :.:*::: : *.: *.* : ::  *     *  .:* .           

Mflv_3389|M.gilvum_PYR-GCK          RQLSQLREVARILGPLLPAAHRDALSDTSDRISMPAPDGPNTLMQALHLL
Mvan_3122|M.vanbaalenii_PYR-1       RNLADIPEVARVLGPLLPDANRAALTDTSDRISMPAPDGPNTLMQALHLL
MMAR_1771|M.marinum_M               RHLKDLDATVAALGSLLPEHNRAMVTSESDRITMPAPDGTRTLIEAARRI
MUL_2014|M.ulcerans_Agy99           RHLKDLDATVAALGSLLPEHNRAMVTSESDRITMPAPDGTRTLIEAARKI
Mb2961|M.bovis_AF2122/97            RDLKDLDAIVAALGSLLPEHHRAMLTPDSDRITMPAPDGIRMLVEAARRI
Rv2936|M.tuberculosis_H37Rv         RDLKDLDAIVAALGSLLPEHHRAMLTPDSDRITMPAPDGIRMLVEAARRI
MLBr_02352|M.leprae_Br4923          RDLKDLGTVVAALGSLLPERSRAMLTPTSDRITMPAPDGTQTLIEAARRI
MAV_3250|M.avium_104                ANPAELPQVAAALTGLEG----IEIDSDTGSVSVFAPDGVATLVEVFRRV
MAB_2752|M.abscessus_ATCC_1997      PPRLDLTLLTSALP-----EGYKATEVTPGEYRVEGVVDPQVLATVTAWC
MSMEG_6509|M.smegmatis_MC2_155      -----------------------QASDDAGETTLEDVFRHYAGSDLEGGA
TH_2745|M.thermoresistible__bu      APIDALRTAP--------YIHEFSTDDGLHTFSVDRTDLDRTMTELT---
                                                                     :                

Mflv_3389|M.gilvum_PYR-GCK          SEADIELSDIALRRPSLDEVFLALTGDHPKARDESEDPLVAADAYA
Mvan_3122|M.vanbaalenii_PYR-1       SEANIELMDIALRRPSLDEVFLALTGDHPRTRDGEADAVVAADAYA
MMAR_1771|M.marinum_M               DEANIELADIALRRPSLDDVFLSMTTDPSEAH--ALSHVASGAML-
MUL_2014|M.ulcerans_Agy99           DEANIELADIALRRPSLDDVFLSMTTDPSEAH--VLSHVASGAML-
Mb2961|M.bovis_AF2122/97            DEARIELADIALRRPSLDDVFLAMTTDPTES----LTHLVSGSAR-
Rv2936|M.tuberculosis_H37Rv         DEARIELADIALRRPSLDHVFLAMTTDPTES----LTHLVSGSAR-
MLBr_02352|M.leprae_Br4923          DEVSVELADIALRRPSLDDVFLSMTTDPSES----LSHLAAGAMR-
MAV_3250|M.avium_104                DALGLELADISLRKPSLDEAFLHLT-----------ERTVARS---
MAB_2752|M.abscessus_ATCC_1997      ARMDVLTTDLRVEKRSLEDVFLDLTGRELR----------------
MSMEG_6509|M.smegmatis_MC2_155      DPRRSGLGEVRSTRRTARRVS-------------------------
TH_2745|M.thermoresistible__bu      ---TLGIEELTVTPASLEDLFLREYQEVPR----------------
                                            ::     :