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TSPIWMAAPPEVHSALLSSGPGLGPLQAAAAAWAGLGEKLALAAVDISFVLGEVSWQWEGAGAESYVAEN IRYKAWLAEAALVCAEAAAALEAAAAAYSGALAEMPTLTELAENHTVHEVLVAMNFFGVNVAPIALNEAD YVRMWIQAAGVMGVYQACSTAALAAVPPAAPAPVLVNPGIDAPAVAVSHLDMLADNDDSGHAGFGSFIDT ASVLSDASYSTAFGSMFDQSSIGVDCVTVDAHHIGAAYYVHYWQYQFLPQFGALLNENPSLAVGLLSMVQ AAAAGAVAPATISPAAGAGVSLSASLPLAITQHLGDVPISVGDQGSYRDVLRGPDEVSGVGQAARPSSVH DTSGVEPMPLETGSQHAGTSGFAGTTASKAVVQPAGLALFGGDEYGRGAASPLLPSLWQTNCFAPVGENR MVELALS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_3002 | - | - | 100% (428) | PPE family protein |
| M. marinum M | MMAR_2806 | - | 2e-80 | 41.69% (427) | PPE family protein |
| M. marinum M | MMAR_5277 | - | 5e-66 | 39.95% (433) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3047c | PPE47 | 4e-64 | 37.28% (464) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0325 | - | 1e-54 | 50.46% (218) | PPE protein |
| M. tuberculosis H37Rv | Rv3018c | PPE46 | 6e-64 | 36.81% (451) | PPE family protein |
| M. leprae Br4923 | MLBr_01828 | PPE | 1e-43 | 50.56% (178) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_0047 | - | 3e-54 | 49.54% (218) | PPE family protein |
| M. avium 104 | MAV_4867 | - | 2e-61 | 36.02% (483) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 2e-58 | 54.13% (218) | PPE family protein |
| M. thermoresistible (build 8) | TH_3569 | - | 2e-53 | 51.83% (218) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_2245 | - | 0.0 | 97.43% (428) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 2e-58 | 54.13% (218) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3047c|M.bovis_AF2122/97 ------------MT---APVWLASPPEVHSALLSAGPGPGSLQAAAAGWS
Rv3018c|M.tuberculosis_H37Rv ------------MT---APVWLASPPEVHSALLSAGPGPGSLQAAAAGWS
Mflv_0325|M.gilvum_PYR-GCK --MTSPVASLAPVT---SPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQ
Mvan_0415|M.vanbaalenii_PYR-1 ------------MS---SPVWMALPPEVHSALLSSGPGPGSMLAAAATWQ
MSMEG_0619|M.smegmatis_MC2_155 ------------MT---APIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQ
TH_3569|M.thermoresistible__bu -----------MMT---APIWMALPPEVHSALLSSGPGPGSLLAAASAWH
MAB_0047|M.abscessus_ATCC_1997 ------------MS---APIWMASPPEVHSALLSAGPGPGALLAAAAQWQ
MAV_4867|M.avium_104 ------------MTSPFGPIWMASPPEVHSALLSAGPGPGPLLAAAGAWT
MLBr_01828|M.leprae_Br4923 ------------MS---APIWMASPPEVHSALLSRGPGSGPLLVAAEAWR
MMAR_3002|M.marinum_M MT---------------SPIWMAAPPEVHSALLSSGPGLGPLQAAAAAWA
MUL_2245|M.ulcerans_Agy99 MT---------------SPIWMAAPPEVHSALLSSGPGLGPLQVAAAAWA
.*:*:* ******::** *** *.: .*. *
Mb3047c|M.bovis_AF2122/97 ALSAEYAAVAQELSAVVAAVGAGVWQGPSAELFVAAYVPYVAWLVQASAD
Rv3018c|M.tuberculosis_H37Rv ALSAEYAAVAQELSVVVAAVGAGVWQGPSAELFVAAYVPYVAWLVQASAD
Mflv_0325|M.gilvum_PYR-GCK SLSAEYASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAV
Mvan_0415|M.vanbaalenii_PYR-1 SLSAEYAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAA
MSMEG_0619|M.smegmatis_MC2_155 SLSAEYAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSAN
TH_3569|M.thermoresistible__bu ALSAEYASAAAELSSVLANVQAGSWEGPSAERYVAAHAPYLAWLTQQSAN
MAB_0047|M.abscessus_ATCC_1997 ALSTQYATAATELTELLGSTVAGSWQGPSAMQYAASHAPYLAWLTQQSAM
MAV_4867|M.avium_104 SLSAQYATAAAELSALLGEAQAGSWEGESAAQYAAAHLPYLAWLQQASAD
MLBr_01828|M.leprae_Br4923 SLSSVYAEMADELVALLVVVPVSSWDGSAAEAYVIAYLPYLGWLRQASVD
MMAR_3002|M.marinum_M GLGEKLALAAVDISFVLGEVSW-QWEGAGAESYVAENIRYKAWLAEAALV
MUL_2245|M.ulcerans_Agy99 GLGEKFALAAVDISFVLGEVSW-QWEGAGAESYVAENIRYKAWLAEAALV
.*. * * :: :: . *:* .: :. * ** : :
Mb3047c|M.bovis_AF2122/97 SAAAAGEHEAAAAGYVCALAEMPTLPELAANHLTHAVLVATNFFGINTIP
Rv3018c|M.tuberculosis_H37Rv SAAAAGEHEAAAAGYVCALAEMPTLPELAANHLTHAVLVATNFFGINTIP
Mflv_0325|M.gilvum_PYR-GCK SAATAVQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIP
Mvan_0415|M.vanbaalenii_PYR-1 GAAAAAQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIP
MSMEG_0619|M.smegmatis_MC2_155 SAAAAVQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIP
TH_3569|M.thermoresistible__bu SAATAGRHETAAAAYSTALATMPTMAELTLNKTTHAVLVATNFLGINTIP
MAB_0047|M.abscessus_ATCC_1997 SATNAVLHETSAAAYTTALAAMPTLAELAANHMIHGVLLATNFFGINTIP
MAV_4867|M.avium_104 SAGAAAQQEVAATAYTTALAAMPTLAELAANHTIHGVLLATNFFGINTIP
MLBr_01828|M.leprae_Br4923 SAVMAAHYETMATAYITTLAMMPTLAELAANRTAHTVLVTTNFFGINTIP
MMAR_3002|M.marinum_M CAEAAAALEAAAAAYSGALAEMPTLTELAENHTVHEVLVAMNFFGVNVAP
MUL_2245|M.ulcerans_Agy99 CDEAAAALEAAAAAYSGALAEMPTLTELAENHTVHEVSVAMNFFGVNVAP
* :. *:.* :** ***:.**: *: * * : **:*:*. *
Mb3047c|M.bovis_AF2122/97 IALNEADYVRMWVQAATVMSAYEAVVGAALVATPHTGPAPVIVKPGANEA
Rv3018c|M.tuberculosis_H37Rv IALNEADYVRMWVQAATVMSAYEAVVGAALVATPHTGPAPVIVKPGANEA
Mflv_0325|M.gilvum_PYR-GCK IALNEADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLPGVGEA
Mvan_0415|M.vanbaalenii_PYR-1 IAMTEADYVRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPGVGEA
MSMEG_0619|M.smegmatis_MC2_155 IALNEADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPGVGEA
TH_3569|M.thermoresistible__bu IALNEADYVRMWIQAATSMSTYQAVAGTAVMSAPASSPAPLLLAPGVSEA
MAB_0047|M.abscessus_ATCC_1997 IALNEADYIRMWIQAATTMGVYQGVSSAALAATTPTQPSPMIMAPG-GEM
MAV_4867|M.avium_104 IAVNEADYARMWVQAATTMGTYQAVAGSALAAAPRTAPAPSIVKPG-GEA
MLBr_01828|M.leprae_Br4923 IARNEIDYVRMWVEAAIAMGTYQEVSTVVVDSAPEAIAAPQIMASDALEA
MMAR_3002|M.marinum_M IALNEADYVRMWIQAAGVMGVYQACSTAALAAVPPAAPAPVLVNPGIDAP
MUL_2245|M.ulcerans_Agy99 IALNEADYVRMWIQAAGVMGVYQACSTAALAAVPPAAPAPVLVNPGIDAP
** .* ** ***::** *..*: .: :.. : .:* :: ..
Mb3047c|M.bovis_AF2122/97 S-----------NAVAA------ATITPFPFGELAK--------------
Rv3018c|M.tuberculosis_H37Rv S-----------NAVAA------ATITPFPWHEIVQ--------------
Mflv_0325|M.gilvum_PYR-GCK GRAAADMSAFAAQPMAA------QAGAAFDVSNIIADIIRLYGEVLRFLF
Mvan_0415|M.vanbaalenii_PYR-1 GRAAADVTAFAAQAQAA------EAGSALDLSNIIADLIRAYGELLRFLF
MSMEG_0619|M.smegmatis_MC2_155 GSASASVQQMSAQATAA------ESGSSLDLSSIISDLLNQYLQGVPGGQ
TH_3569|M.thermoresistible__bu ADAMATTQQIGSQATAA------DSGTALNLSDLIANLLQYYQDYLDQLF
MAB_0047|M.abscessus_ATCC_1997 SRMSADMMSMAAQPQAA------ESGSALDSSNNIMDQLMR---------
MAV_4867|M.avium_104 N-------NLAANAAQN------SSG---DWWQNFIQQLSQ---------
MLBr_01828|M.leprae_Br4923 SSDQPSPTAPSQSPQVQNWLQWLQKIGYTDFYNTLVQPLITSLTNHPFFQ
MMAR_3002|M.marinum_M AVAVSHLDMLADNDDSG-------HAGFGSFIDTAS--------------
MUL_2245|M.ulcerans_Agy99 AVAVSHLDMLADNDDSG-------HAGFGSFIDTAS--------------
. .
Mb3047c|M.bovis_AF2122/97 -----------------------------------------FLEMAAQAF
Rv3018c|M.tuberculosis_H37Rv -----------------------------------------FLEETFAAY
Mflv_0325|M.gilvum_PYR-GCK EPIFNF----------------------------LRDPIGNTFALITDFL
Mvan_0415|M.vanbaalenii_PYR-1 EPIFDF----------------------------LRDPLGNTIKLITDFL
MSMEG_0619|M.smegmatis_MC2_155 -AILDF----------------------------LKDPLGNLGRLLTDFM
TH_3569|M.thermoresistible__bu GPIVDF----------------------------LRDPIGNLFQLIDDFL
MAB_0047|M.abscessus_ATCC_1997 -----F----------------------------MTNPLGTLQDMIEDFM
MAV_4867|M.avium_104 -----F----------------------------FQN----IQKMLQDFW
MLBr_01828|M.leprae_Br4923 GMFSGFDPWLPSLGNPLSFLSPFNIAFALGTPMDIGSYVGYLSQTFAFIG
MMAR_3002|M.marinum_M -------------------------------------------VLSDASY
MUL_2245|M.ulcerans_Agy99 -------------------------------------------VLSDASY
Mb3047c|M.bovis_AF2122/97 TEVGELIMKS---AEA-----WAVGFVELITGLVN--FEPWLVLTGMIDM
Rv3018c|M.tuberculosis_H37Rv DQYLSALLSE---LPA-----VAWVWFQLFVDILG--FNIIGFIITLASN
Mflv_0325|M.gilvum_PYR-GCK TNPVQALITW---GPF-----LLAVVYQAVSWVGA--SILYPSLFLLPLL
Mvan_0415|M.vanbaalenii_PYR-1 TNPAQALITW---GPF-----LAAVAYQAVSWVGA--SILYPSLLLLPLV
MSMEG_0619|M.smegmatis_MC2_155 TNPAGALATW---WPF-----LFGVAYQVFFNLVG--WPTWGMIFASPFL
TH_3569|M.thermoresistible__bu TNPAGALVTW---WPL-----LFAVAYQVFTNLVG--WPTWAMILASPVL
MAB_0047|M.abscessus_ATCC_1997 RNPVAAFFAW---FPL-----LFFIAYEAFFIPFG--FTFWGVLLSAPAW
MAV_4867|M.avium_104 ANLPAFLAAN---GPL-----LFFVAYQVFFNAVG--WPTWGAILTAPFL
MLBr_01828|M.leprae_Br4923 ADLAAAFASG---NPVTIGFTLLFTTIEAIGTIITDTIALVKTMIEQSFV
MMAR_3002|M.marinum_M STAFGSMFDQSSIG-------VDCVTVDAHHIGAAYYVHYWQYQFLPQFG
MUL_2245|M.ulcerans_Agy99 STAFGSMFDQPSIG-------VDCVTVDAHHIGAAYYVHYWQYQFLPQFG
: :
Mb3047c|M.bovis_AF2122/97 FFATVGFALGVFVLVPLLEFA-----------VVLELAILSIGWIISNIF
Rv3018c|M.tuberculosis_H37Rv AQLLTEFAINASYVAVGLLYA-----------IAGVIDIV-VEWVIGNLF
Mflv_0325|M.gilvum_PYR-GCK ATTLAIVAGVGQHLLSLLNTP-PAEEAAEEPAPAQSAPSRPDQQSFPATM
Mvan_0415|M.vanbaalenii_PYR-1 ATTLAIVLGVGAYLLENLPAP-AEDAPAEEPAASSPAPTRADQPSPAIAV
MSMEG_0619|M.smegmatis_MC2_155 IPALAALGITGLVLLIDHVLNNPVDVPAEDEAPQEVAAAPRTDQPLAVGI
TH_3569|M.thermoresistible__bu IPLAITLGVAGLVMIADQAQP-----PAEEAAPEEDVAAP----------
MAB_0047|M.abscessus_ATCC_1997 LPIVLGLALSALVPPAGIEEPGQEDEPGREPTRIE-RRSPQQDLQLAHVP
MAV_4867|M.avium_104 LPLLLGIGLSSLLAAPAEIAP-VAAPAAITPVLAS-NKPPTLPAAVALAP
MLBr_01828|M.leprae_Br4923 LLPMILPLLTAPLAVATAGAAGSFAGLSELAGLVGVAPPGLPSAPPVAAV
MMAR_3002|M.marinum_M ALLNENPSLAVGLLSMVQAAA-----------------------------
MUL_2245|M.ulcerans_Agy99 ALLNENPSLAVGLLSMVQAAA-----------------------------
Mb3047c|M.bovis_AF2122/97 GAIPVLAGPLLGALAAAV--VPGVAGVTGLAGLAAVPAVGAAAGAPAALV
Rv3018c|M.tuberculosis_H37Rv GVVPLLGGPLLGALAAAV--VPGVAGLAGVAGLAALPAVGAAAGAPAALV
Mflv_0325|M.gilvum_PYR-GCK SAPPPPSGAPIAANTVSA--GSPPAPGAPAAAAATFVPYVVAGRDPYEGF
Mvan_0415|M.vanbaalenii_PYR-1 SAPPPPSSAAATVGTVAT--GTAPAPGAPAAATASFVPYAVAGRDPGTGF
MSMEG_0619|M.smegmatis_MC2_155 SPAGVPGSAATAAAPAPA--PAGTTVAAPAPAAATFVPYAVANRDPGEGF
TH_3569|M.thermoresistible__bu ---------VRAEPQNPL--PLTXXX------------------------
MAB_0047|M.abscessus_ATCC_1997 SGSPTPGGSTTTTVTSGG--SAPPAP-APATATPAYMVYAVQEDPPAARF
MAV_4867|M.avium_104 S-VATPAGAPASTVAAGS--GAAAAP-GPAAAAGNFAYLVAFGGDPDTGV
MLBr_01828|M.leprae_Br4923 APVVPPSMPTLASIPTPTPMPAPAASTAPVVTPPGPPPVTAPPSVTGAGV
MMAR_3002|M.marinum_M -----AGAVAPATISPAAGAGVSLSASLPLAITQHLGDVPISVGDQGSYR
MUL_2245|M.ulcerans_Agy99 -----AGAVAPATVSLAVGAEASLSASLPLAITQHLGDVPISVGDQGSYR
Mb3047c|M.bovis_AF2122/97 GSVAPVSGGVVSPQARLVSAVEPAPASTSVS-------------------
Rv3018c|M.tuberculosis_H37Rv GSVAPVSGGVVSPQARLVSAVEPAPASTSVS-------------------
Mflv_0325|M.gilvum_PYR-GCK SPTVRDSTGAKAPAGTIPAAASGIAASAAERRKRRRRQKEEIKGRGYADA
Mvan_0415|M.vanbaalenii_PYR-1 SPTVRDSTSAKAPASGIPAAASGVAASAAERRKRRRRQKDEIAGRAYADA
MSMEG_0619|M.smegmatis_MC2_155 TPTLGNKSQVAAPASGVPAAASGVAASLASRRKRRRKKGAQIEERGYADA
TH_3569|M.thermoresistible__bu --------------------------------------------------
MAB_0047|M.abscessus_ATCC_1997 GPTLNEGSGAKAPAAGISAAAAAAAS-ARSRARRKRAARIKDPAPQFMDM
MAV_4867|M.avium_104 GPTLSGRGGAKAPAATIPAAGAAAPARAEARARRRRRAALHDYSDEFLDM
MLBr_01828|M.leprae_Br4923 ESFGYLVGRLPSTARGVVGTSVRQQSSAPDRIEAPDAAATPQEQARSRWR
MMAR_3002|M.marinum_M DVLRGPDEVSGVGQAARPSSVHDTSGVEPMP-------------------
MUL_2245|M.ulcerans_Agy99 DVLRGPDEVSGVGQAARPSSVHDTSGVEPMP-------------------
Mb3047c|M.bovis_AF2122/97 -------------------VLASDRGAGALGFVGTAGKES-VGQPAGLTV
Rv3018c|M.tuberculosis_H37Rv -------------------VLASDRGAGALGFVGTAGKES-VGQPAGLTV
Mflv_0325|M.gilvum_PYR-GCK YADYEELPDDGPPEQPAPRVTASTRGAGPMGFAGTVSRGD--EQAGGLTT
Mvan_0415|M.vanbaalenii_PYR-1 YADYEPEPDDEPPVRQEPRIAATERGAGPMGFAGTVSRDA--AQAGGLTT
MSMEG_0619|M.smegmatis_MC2_155 YMDYEE-PDEDPAPQPEPRVRASERGSDAMGFTGTVTRHD--VTAAGLTT
TH_3569|M.thermoresistible__bu --------------------------------------------------
MAB_0047|M.abscessus_ATCC_1997 NSSVAPDFSES-AARQTTGVGASARGAGRLGFAGTAPAAAGTTAAAGLVE
MAV_4867|M.avium_104 DSGFGVPPDYG-AEEELAAAVASGQGAGTLGFAGTQQRRK-AFQAAGLTK
MLBr_01828|M.leprae_Br4923 RRAKVTPFDSSGSPNPKAAPTASDQGAGTLGLAGTARQAS-SGPATGLVT
MMAR_3002|M.marinum_M -------------------LETGSQHAGTSGFAGTTASKA-VVQPAGLAL
MUL_2245|M.ulcerans_Agy99 -------------------LETGSQHAGTSGFAGTTVSKA-VVQPAGLAL
Mb3047c|M.bovis_AF2122/97 LAD----EFGDGAPVPMLPGSWGPDLVGV---------AGDGGLVSV
Rv3018c|M.tuberculosis_H37Rv LAD----EFGDGAPVPMLPGSWGPDLVGV---------AGDGGLVSV
Mflv_0325|M.gilvum_PYR-GCK LAG---DSFGGGPREPMLPGTWDPDATDDRHTDGRDGHDGHDGKEKP
Mvan_0415|M.vanbaalenii_PYR-1 LPG---DPFGGGPKAPMLPGTWDPDTEPD------ERHNHHDGKDSQ
MSMEG_0619|M.smegmatis_MC2_155 LTG---DTFDDRPVTPMLPGTWDGDENPA------PSPDDPEGGPRR
TH_3569|M.thermoresistible__bu -----------------------------------------------
MAB_0047|M.abscessus_ATCC_1997 RDSGTAEALDGARTVPMLPTSWGTDSEHGP------DRPAEGGSST-
MAV_4867|M.avium_104 LAD---DDFGGSPRMPMVPGTWEQDTQNG-------AHPTEPGKGG-
MLBr_01828|M.leprae_Br4923 LSN---GTFSDSPRAPMLPRTWGADPTFCYN---AADIGPAGGWDDE
MMAR_3002|M.marinum_M FGG---DEYGRGAASPLLPSLWQTNCFAPVG----ENRMVELALS--
MUL_2245|M.ulcerans_Agy99 FGG---DEYGRGAASPLLPSLWQTNCFAPVG----ENRMVELALS--