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MTASLDFATLPPEINSARMYSGPGSAPMLAAASAWKGLAAELRVTVLSYDSVLRALTGEEWYGPASASMA AAAAPYVAWMSTTAAQAEESAVQAAAAAAAYEAAFSATVAPTVITANRAQLMVLVATNVLGQNTPAIAAV EAQYCEMWAQDAMAMYGYAGSSAAATRLSEFLEPQHNTNPAGLLAQQSTLAQLMSAVPNVLQGLASSNTS ASAPSGLLSTLLSGNGQSWLATLWSEFGPNANIWNTIASTGFLLPSNMVTPFLGMLGTAAVADAAEDALG TTGSGALGGALSAPLGSVGGQAGLAAAGNAAIVGKLSVPPSWTGAAPLASPLGSALGGTPMVAPPPTAAA GMPGVPFGNMAGQPFGRALPQYGFRPTFVARPPAAG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_2683 | - | - | 100% (386) | PPE family protein, PPE31 |
| M. marinum M | MMAR_2681 | - | 1e-89 | 48.04% (433) | PPE family protein, PPE31_1 |
| M. marinum M | MMAR_1849 | - | 2e-89 | 48.47% (425) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1836 | PPE31 | 1e-157 | 71.32% (401) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0325 | - | 6e-27 | 29.52% (393) | PPE protein |
| M. tuberculosis H37Rv | Rv1807 | PPE31 | 1e-155 | 70.82% (401) | PPE family protein |
| M. leprae Br4923 | MLBr_01182 | - | 3e-43 | 31.03% (419) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_0809c | - | 1e-27 | 38.79% (165) | PPE family protein |
| M. avium 104 | MAV_2914 | - | 2e-82 | 46.04% (391) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 1e-33 | 31.63% (411) | PPE family protein |
| M. thermoresistible (build 8) | TH_3113 | - | 2e-35 | 29.29% (420) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_3074 | - | 0.0 | 98.70% (386) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 1e-29 | 29.74% (390) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE
MSMEG_0619|M.smegmatis_MC2_155 ----------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAE
MAB_0809c|M.abscessus_ATCC_199 ---------MLAAPVWMASPPEVHSALLSSGPGPGPLLAAAAEWSSLGAH
TH_3113|M.thermoresistible__bu ----------------MALPPEVHSTLLRTGPGPGALSAAADAWRMLSDE
MMAR_2683|M.marinum_M ---------MTASLDFATLPPEINSARMYSGPGSAPMLAAASAWKGLAAE
MUL_3074|M.ulcerans_Agy99 ---------MTASLDFATLPPEINSARMYSGPGSAPMLAAASAWKGLAAE
Mb1836|M.bovis_AF2122/97 -------------MDFATLPPEINSARMYSGAGSAPMLAAASAWHGLSAE
Rv1807|M.tuberculosis_H37Rv -------------LDFATLPPEINSARMYSGAGSAPMLAAASAWHGLSAE
MAV_2914|M.avium_104 ------------MIDFAALPPEINSARIYAGPGSAPMMSAAAAWNTMAAE
MLBr_01182|M.leprae_Br4923 ------------MFDFAALSPETNSTRMYLGPGSSPILTAAAAWVVLAKE
: .** :*: : *.*...: :*. * :. .
Mflv_0325|M.gilvum_PYR-GCK YASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA
Mvan_0415|M.vanbaalenii_PYR-1 YAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA
MSMEG_0619|M.smegmatis_MC2_155 YAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAA
MAB_0809c|M.abscessus_ATCC_199 YSATAQELRAILAATHASAWHGPSAETYVAAHTPYLEWLNQGALESNARA
TH_3113|M.thermoresistible__bu YRAAAVELAAVVSQTCATAWEGVGADAYAAAHGPYLFWLTDTAAAAAAAG
MMAR_2683|M.marinum_M LRVTVLSYDSVLRALTGEEWYGPASASMAAAAAPYVAWMSTTAAQAEESA
MUL_3074|M.ulcerans_Agy99 LRVTVLSYDSVLRALTGEEWYGPASASMAAAAAPYVAWMSTTAAQAEESA
Mb1836|M.bovis_AF2122/97 LRASALSYSSVLSTLTGEEWHGPASASMTAAAAPYVAWMSVTAVRAEQAG
Rv1807|M.tuberculosis_H37Rv LRASALSYSSVLSTLTGEEWHGPASASMTAAAAPYVAWMSVTAVRAEQAG
MAV_2914|M.avium_104 MRSAAASYGAVISELTSADWFGPSSMSMLAAVTPYLTWLTDTATRAEEAA
MLBr_01182|M.leprae_Br4923 LTAAAQGLQSAVEALL-TTFEGESAAALAERVTPYEKWLTQNAASAELTA
:. : : : * .: ** *: : . .
Mflv_0325|M.gilvum_PYR-GCK VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE
Mvan_0415|M.vanbaalenii_PYR-1 AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE
MSMEG_0619|M.smegmatis_MC2_155 VQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNE
MAB_0809c|M.abscessus_ATCC_199 VQHGAAAGAYSTALAVMPTLAELAANHATHAALVATNFFGINTIPILATE
TH_3113|M.thermoresistible__bu AQLEAAAAAHASALAAMPTMAELTANRTTHAALVATNFFGVNTIPIAVNE
MMAR_2683|M.marinum_M VQAAAAAAAYEAAFSATVAPTVITANRAQLMVLVATNVLGQNTPAIAAVE
MUL_3074|M.ulcerans_Agy99 VQAAAAAAAYEAAFSATVAPTVITANRAQLMVLVATNVLGQNTPTIAAVE
Mb1836|M.bovis_AF2122/97 AQAEAAAAAYEAAFAATVPPPVIEANRAQLMALIATNVLGQNAPAIAATE
Rv1807|M.tuberculosis_H37Rv AQAEAAAAAYEAAFAATVPPPVIEANRAQLMALIATNVLGQNAPAIAATE
MAV_2914|M.avium_104 AQANSAATAYEAAFAMTVPPAVVAANRAQLATLVATNVFGQNTPAIAATE
MLBr_01182|M.leprae_Br4923 TQLTVAANAYETAFTMTVPPLMVFVNRAQACLLIMSNIFGQNSTAIAEKE
.* ** *: :*:: . : *:: *: :*.:* *: .* *
Mflv_0325|M.gilvum_PYR-GCK ADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLPGVGEAGRAAA
Mvan_0415|M.vanbaalenii_PYR-1 ADYVRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPGVGEAGRAAA
MSMEG_0619|M.smegmatis_MC2_155 ADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPGVGEAGSASA
MAB_0809c|M.abscessus_ATCC_199 ADYVRMWVQAATTMATYQTASEVALASAPPSTPPPSILHD----------
TH_3113|M.thermoresistible__bu ADYARMWIQAATTMATYEAVASAAVSATPRTVAPPPILGAGTGESATAAI
MMAR_2683|M.marinum_M AQYCEMWAQDAMAMYGYAGSSAAAT-RLSEFLEPQHNTNPAGLLAQ----
MUL_3074|M.ulcerans_Agy99 AQYCEMWAQDAMAMYGYAGSSAAAT-RLSEFLAPQHNTNPAGLLAQ----
Mb1836|M.bovis_AF2122/97 AQYAEMWSQDAMAMYGYAGASAAAT-QLTPFTEPVQTTNASGLAAQSAAI
Rv1807|M.tuberculosis_H37Rv AQYAEMWSQDAMAMYGYAGASAAAT-QLTPFTEPVQTTNASGLAAQSAAI
MAV_2914|M.avium_104 AEYGQMWAQDAAAMNGYAVASTAAT-RLTPMTAPRSNTSPEGVAAQ----
MLBr_01182|M.leprae_Br4923 AEYTEMWIQDAAAMTSYQASVLEAVGATKAFTAPPLGVNEVGLAQEVVEE
*:* .** * * :* * * .
Mflv_0325|M.gilvum_PYR-GCK DMSAFAAQPMAAQAGAAFDVSNIIADIIRLYGEVLRFLFEPIFNFLR---
Mvan_0415|M.vanbaalenii_PYR-1 DVTAFAAQAQAAEAGSALDLSNIIADLIRAYGELLRFLFEPIFDFLR---
MSMEG_0619|M.smegmatis_MC2_155 SVQQMSAQATAAESGSSLDLSSIISDLLNQYLQGVPGG-QAILDFLK---
MAB_0809c|M.abscessus_ATCC_199 --HDHGHDDHDHEHGHDDDHG---------HGDLDPTDPEWWVHVAG---
TH_3113|M.thermoresistible__bu TGAHVTAELRAAESRTLLDEINELIDRLFAPLFPPGFADALPDGLLGTLL
MMAR_2683|M.marinum_M -----------QSTLAQLMSAVPNVLQGLASSN--TSASAPSGLLST---
MUL_3074|M.ulcerans_Agy99 -----------QSTLAQLMSAVPNVLQGLASSN--TSASAPSGLLST---
Mb1836|M.bovis_AF2122/97 AHATGASAGAQQTTLSQLIAAIPSVLQGLSSSTAATSASGPSGLLG----
Rv1807|M.tuberculosis_H37Rv AHATGASAGAQQTTLSQLIAAIPSVLQGLSSSTAATFASGPSGLLG----
MAV_2914|M.avium_104 -----------ATSVTNAAQAPAGTVQSTVSSS------GLAGLLS----
MLBr_01182|M.leprae_Br4923 VVEEVVEEVVEAEQAISQAALDQAVNEGMEATVVPQVDQQVNVDVATPQ-
.
Mflv_0325|M.gilvum_PYR-GCK -----------DPIGNTFALITDFLTNPVQALITWGPFLLAVVYQA----
Mvan_0415|M.vanbaalenii_PYR-1 -----------DPLGNTIKLITDFLTNPAQALITWGPFLAAVAYQA----
MSMEG_0619|M.smegmatis_MC2_155 -----------DPLGNLGRLLTDFMTNPAGALATWWPFLFGVAYQVFFNL
MAB_0809c|M.abscessus_ATCC_199 -----------EMVEHFELLLNNLLTDPAALLTNLPMVLADVAFHA----
TH_3113|M.thermoresistible__bu APLLPGATGDGPPMATIMSFLLMGLSNPAYLFPVLVYLLFTGVVHTTVAV
MMAR_2683|M.marinum_M ------------LLSGNGQSWLATLWSEFGPNANIWNTIASTG-------
MUL_3074|M.ulcerans_Agy99 ------------LLSGNGQSWLATLWSEFGPNANIWNTIASTG-------
Mb1836|M.bovis_AF2122/97 -------------ILGSGSSWLDKLWALLDPNSNFWNTIASSG-------
Rv1807|M.tuberculosis_H37Rv -------------IVGSGSSWLDKLWALLDPNSNFWNTIASSG-------
MAV_2914|M.avium_104 ---------------GSDNSAFGTFTNGNFFSTAVVNGSLAGG-------
MLBr_01182|M.leprae_Br4923 -----------TAVPDSSSAAAPQLWGGFAQHLSPINDTLSMINNH----
:
Mflv_0325|M.gilvum_PYR-GCK VSWVGASILYPSLFLLPLLATT---LAIVAGVG--QHLLSLLNTPPAEEA
Mvan_0415|M.vanbaalenii_PYR-1 VSWVGASILYPSLLLLPLVATT---LAIVLGVG--AYLLENLPAPAEDAP
MSMEG_0619|M.smegmatis_MC2_155 VGWPTWGMIFASPFLIPALAALGI-TGLVLLID--HVLNNPVDVPAEDEA
MAB_0809c|M.abscessus_ATCC_199 AQLASTIGQFAPALIQPALALAIANLGWAAGFAGLAGIQPSPEILAVEPG
TH_3113|M.thermoresistible__bu SGMLAQLVPLMPALLPVAVAALGGLAGVWAGLSGLAGLAGLTAVPAADGG
MMAR_2683|M.marinum_M -------FLLPSNMVTPFLGMLGTAAVADAAEDALGTTGSGALGGALSAP
MUL_3074|M.ulcerans_Agy99 -------FLLPSNMVTPFLGMLDTAAVADAAEDALRTTGSGALGGALSAP
Mb1836|M.bovis_AF2122/97 -------LFLPSNTIAPFLGLLGGVAAADAAGDVLGEATSGGLGGALVAP
Rv1807|M.tuberculosis_H37Rv -------LFLPSNTIAPFLGLLGGVAAADAAGDVLGEATSGGLGGALVAP
MAV_2914|M.avium_104 -------PFNPQFIISSVQGVLAAQHATTLGG--LGDFAADAEG-AATAD
MLBr_01182|M.leprae_Br4923 -------AGMANAGLSLVNGMGSAMKSLAPTTTKAAESAFKAMGSAVQST
: . .
Mflv_0325|M.gilvum_PYR-GCK AEEPAPAQSAPSRPDQQSFPATMSAPPPPSGAPIAANTVSAGSPPAPGAP
Mvan_0415|M.vanbaalenii_PYR-1 AEEPAASSPAPTRADQPSPAIAVSAPPPPSSAAATVGTVATGTAPAPGAP
MSMEG_0619|M.smegmatis_MC2_155 PQEVAAAP----RTDQP-LAVGISPAGVPGSAATAAAPAPAPAGTTVAAP
MAB_0809c|M.abscessus_ATCC_199 SVEDAPMAASAGTALAPSPPASAAAPAAPASAPAPTASGTAPAPPSP-PP
TH_3113|M.thermoresistible__bu ASAAPVPAGGPSLPSGSSAPPAPTGSAAPTTGTAPGGAGSPPPAGHSVPP
MMAR_2683|M.marinum_M LGSVGG--QAGLAAA--GNAAIVGKLSVPPSWTGAAPLASPLGSALGGTP
MUL_3074|M.ulcerans_Agy99 LGSVGG--QAGLAAA--GNAAIVGKLSVPPSWTGAAPLASPLGSALGGTP
Mb1836|M.bovis_AF2122/97 LGSAGG--LGGTVAAGLGNAATVGTLSVPPSWTAAAPLASPLGSALGGTP
Rv1807|M.tuberculosis_H37Rv LGSAGG--LGGTVAAGLGNAATVGTLSVPPSWTAAAPLASPLGSALGGTP
MAV_2914|M.avium_104 LAASTG--GSAPVAAGMGRAQLVGSLSVPQGWANAATINPGQAAVPATGV
MLBr_01182|M.leprae_Br4923 GRGLLGSSSGGHVTAQLGRAASIGSLRVPQTWTTASQPVTAATRALSPAR
. . * . . .
Mflv_0325|M.gilvum_PYR-GCK AAAAATFVPYVVAGRD-PYEGFSPTVRDSTGAKAPAGTIPAAASGIAASA
Mvan_0415|M.vanbaalenii_PYR-1 AAATASFVPYAVAGRD-PGTGFSPTVRDSTSAKAPASGIPAAASGVAASA
MSMEG_0619|M.smegmatis_MC2_155 APAAATFVPYAVANRD-PGEGFTPTLGNKSQVAAPASGVPAAASGVAASL
MAB_0809c|M.abscessus_ATCC_199 VGDPGFSFPYAVGGGPRLGTGLALAAQVRRGTSAAARSSAREQAAAAETA
TH_3113|M.thermoresistible__bu APHSAPPVGTSGPPYLIAAQPAPGVARRSAGARRAASIVEPAGSAAAAAA
MMAR_2683|M.marinum_M MVAPP-----PTAAAGMPGVPFGNMAGQP--FGRALPQYGFRPTFVARPP
MUL_3074|M.ulcerans_Agy99 MVAPP-----PTAAAGMPGMPFGNMAGQP--FGRALPQYGFRPTFVARPP
Mb1836|M.bovis_AF2122/97 MVAPP-----PAVAAGMPGMPFGTMGGQG--FGRAVPQYGFRPNFVARPP
Rv1807|M.tuberculosis_H37Rv MVAPP-----PAVAAGMPGMPFGTMGGQG--FGRAVPQYGFRPNFVARPP
MAV_2914|M.avium_104 TGLTD-----AASAAGGPGGVAGPVGGTGRRLRRAIPKYGFRPVVMPRPP
MLBr_01182|M.leprae_Br4923 VAVATESESAPLLGGGLPMAPMVPGGGSGTGGVNTALRLQPRAFVMPRNP
. . .
Mflv_0325|M.gilvum_PYR-GCK AERRKRRRRQKEEIKGRGYADAYADYEELPDDGPPEQPAPRVTASTRGAG
Mvan_0415|M.vanbaalenii_PYR-1 AERRKRRRRQKDEIAGRAYADAYADYEPEPDDEPPVRQEPRIAATERGAG
MSMEG_0619|M.smegmatis_MC2_155 ASRRKRRRKKGAQIEERGYADAYMDYEE-PDEDPAPQPEPRVRASERGSD
MAB_0809c|M.abscessus_ATCC_199 AARQARRRRDKGKQQGRG-----IEYMDMNATARCEEPAPDTTASHRGAG
TH_3113|M.thermoresistible__bu ARESAPIRRRRGQKDGLHG--------HRHEHQQPASMSAATAPSAAGIR
MMAR_2683|M.marinum_M AAG-----------------------------------------------
MUL_3074|M.ulcerans_Agy99 AAG-----------------------------------------------
Mb1836|M.bovis_AF2122/97 AAG-----------------------------------------------
Rv1807|M.tuberculosis_H37Rv AAG-----------------------------------------------
MAV_2914|M.avium_104 AAG-----------------------------------------------
MLBr_01182|M.leprae_Br4923 AAG-----------------------------------------------
*
Mflv_0325|M.gilvum_PYR-GCK PMGFAGTVSRGDEQAGGLTTLA-GDSFGGGPREPMLPGTWDPDATDDRHT
Mvan_0415|M.vanbaalenii_PYR-1 PMGFAGTVSRDAAQAGGLTTLP-GDPFGGGPKAPMLPGTWDPDTEPD---
MSMEG_0619|M.smegmatis_MC2_155 AMGFTGTVTRHDVTAAGLTTLT-GDTFDDRPVTPMLPGTWDGDENPAP--
MAB_0809c|M.abscessus_ATCC_199 TMGFAGTVIKTGATASGLAMLSRDDDLFEGVRAPMVPNTWDP--------
TH_3113|M.thermoresistible__bu VLGGAGRISRTRGSVPHAEITP-GDPTEPSSPTDRAHRPAEPN-------
MMAR_2683|M.marinum_M --------------------------------------------------
MUL_3074|M.ulcerans_Agy99 --------------------------------------------------
Mb1836|M.bovis_AF2122/97 --------------------------------------------------
Rv1807|M.tuberculosis_H37Rv --------------------------------------------------
MAV_2914|M.avium_104 --------------------------------------------------
MLBr_01182|M.leprae_Br4923 --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK DGRDGHDGHDGKEKP
Mvan_0415|M.vanbaalenii_PYR-1 ---ERHNHHDGKDSQ
MSMEG_0619|M.smegmatis_MC2_155 ----SPDDPEGGPRR
MAB_0809c|M.abscessus_ATCC_199 ----EHGRQD-----
TH_3113|M.thermoresistible__bu ---------------
MMAR_2683|M.marinum_M ---------------
MUL_3074|M.ulcerans_Agy99 ---------------
Mb1836|M.bovis_AF2122/97 ---------------
Rv1807|M.tuberculosis_H37Rv ---------------
MAV_2914|M.avium_104 ---------------
MLBr_01182|M.leprae_Br4923 ---------------