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MAMDYGMLPPEVTSALMYAGPGSSSMVAAASAWNALAAELNSTAQGYLTVITQLSSEEWMGPASATMAQA VEPYMTWMSVTAGQAEHAATQAQSAAAAFETAFAAVVPPPLIATNRAELTQALQTNMFGLNNGVIAQLEA QYAEMWAQDASAMYNYAASSALATKIESFTEAPTIANPAASTTQGAAVSAAQATSAASTQSTVQSFLSQI TSQLGQLASPSGTQSFVSQLGASNPILTEIWFLLTGQTVLPNNLGTFMQGYSNYASFFYNTEGLPYFSVG MGNFGVQMAKTLGLITQPAAAAAAALPKVPGLGGALGAIGSAGSQVAAGLGSGAHVGHLAVPASWPGASV AEAVRPTVQAVSEPITSPEAANVIGGMPVGATGAGRGVGSGPRYGFKPTVMARPLPAG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_2671 | - | - | 100% (408) | PPE family protein, PPE26 |
| M. marinum M | MMAR_1904 | - | 6e-99 | 47.43% (409) | PPE family protein |
| M. marinum M | MMAR_2516 | - | 7e-95 | 48.07% (414) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1817 | PPE26 | 1e-113 | 55.66% (415) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0325 | - | 3e-25 | 32.41% (216) | PPE protein |
| M. tuberculosis H37Rv | Rv1789 | PPE26 | 1e-113 | 55.66% (415) | PPE family protein |
| M. leprae Br4923 | MLBr_01182 | - | 9e-45 | 31.46% (426) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_4783 | - | 2e-28 | 27.65% (405) | PPE family protein |
| M. avium 104 | MAV_2926 | - | 1e-112 | 53.49% (415) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 1e-29 | 29.83% (409) | PPE family protein |
| M. thermoresistible (build 8) | TH_3113 | - | 4e-32 | 29.30% (413) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_3087 | - | 0.0 | 99.26% (406) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 5e-29 | 29.11% (395) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_2671|M.marinum_M -----------MAMDYGMLPPEVTSALMYAGPGSSSMVAAASAWNALAAE
MUL_3087|M.ulcerans_Agy99 -------------MDYGMLPPEVTSALMYAGPGSSSMVAAASAWNALAAE
Mb1817|M.bovis_AF2122/97 -------------MDFGALPPEVNSVRMYAGPGSAPMVAAASAWNGLAAE
Rv1789|M.tuberculosis_H37Rv -------------MDFGALPPEVNSVRMYAGPGSAPMVAAASAWNGLAAE
MAV_2926|M.avium_104 -----------MMLDYGTFPPEFNSARIYSGPGSGSLVAAASAWSSLAAE
MLBr_01182|M.leprae_Br4923 ------------MFDFAALSPETNSTRMYLGPGSSPILTAAAAWVVLAKE
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE
MSMEG_0619|M.smegmatis_MC2_155 ----------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAE
MAB_4783|M.abscessus_ATCC_1997 ----------MTAPVWMAAPPEVHSALLSSGPGPGSLFAAADAWRSLSTE
TH_3113|M.thermoresistible__bu ----------------MALPPEVHSTLLRTGPGPGALSAAADAWRMLSDE
.** * : ***...: :*. :* *: *
MMAR_2671|M.marinum_M LNSTAQGYLTVITQLSSEEWMGPASATMAQAVEPYMTWMSVTAGQAEHAA
MUL_3087|M.ulcerans_Agy99 LNSTAQGYLTVITQLSSEEWMGPASATMAQAVEPFMTWMSVTAGQAEHAA
Mb1817|M.bovis_AF2122/97 LSSAATGYETVITQLSSEGWLGPASAAMAEAVAPYVAWMSAAAAQAEQAA
Rv1789|M.tuberculosis_H37Rv LSSAATGYETVITQLSSEGWLGPASAAMAEAVAPYVAWMSAAAAQAEQAA
MAV_2926|M.avium_104 LNAAALSYDKVVTALASEEWLGSASASMASAVAPYVGWMSTTAAQAEEAA
MLBr_01182|M.leprae_Br4923 LTAAAQGLQSAVEALLTT-FEGESAAALAERVTPYEKWLTQNAASAELTA
Mflv_0325|M.gilvum_PYR-GCK YASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA
Mvan_0415|M.vanbaalenii_PYR-1 YAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA
MSMEG_0619|M.smegmatis_MC2_155 YAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAA
MAB_4783|M.abscessus_ATCC_1997 YSSAANELTTTLGSVRAGVWDGASAEQYQTAHVPYLSWLHETSAVSAGVA
TH_3113|M.thermoresistible__bu YRAAAVELAAVVSQTCATAWEGVGADAYAAAHGPYLFWLTDTAAAAAAAG
::* : : : * .: *: *: :. . ..
MMAR_2671|M.marinum_M TQAQSAAAAFETAFAAVVPPPLIATNRAELTQALQTNMFGLNNGVIAQLE
MUL_3087|M.ulcerans_Agy99 TQAQSAAAAFETAFAAVVPPPLIATNLAELTQALQTNMFGLNNGVIAQLE
Mb1817|M.bovis_AF2122/97 TQARAAAAAFEAAFAATVPPPLIAANRASLMQLISTNVFGQNTSAIAAAE
Rv1789|M.tuberculosis_H37Rv TQARAAAAAFEAAFAATVPPPLIAANRASLMQLISTNVFGQNTSAIAAAE
MAV_2926|M.avium_104 SQARAAAAAYEAALAASVPPPLIAANRMQVSQLQATNVLGQNTPLIAQLE
MLBr_01182|M.leprae_Br4923 TQLTVAANAYETAFTMTVPPLMVFVNRAQACLLIMSNIFGQNSTAIAEKE
Mflv_0325|M.gilvum_PYR-GCK VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE
Mvan_0415|M.vanbaalenii_PYR-1 AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE
MSMEG_0619|M.smegmatis_MC2_155 VQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNE
MAB_4783|M.abscessus_ATCC_1997 AQTETAATAYSEALATMPTLGELAANHATHGALVATNFFGINTIPIAVNE
TH_3113|M.thermoresistible__bu AQLEAAAAAHASALAAMPTMAELTANRTTHAALVATNFFGVNTIPIAVNE
* ** *. *:: . : * :*.:* *. ** *
MMAR_2671|M.marinum_M AQYAEMWAQDASAMYNYAASSALATKIES-FTEAPTIANPAASTTQGAAV
MUL_3087|M.ulcerans_Agy99 AQYAEMWAQDASAMYNYAASSALATKIES-FTEAPTIASPAASTTQGAAV
Mb1817|M.bovis_AF2122/97 AQYGEMWAQDSAAMYAYAGSSASASAVTP-FSTPPQIANPTAQGTQAAAV
Rv1789|M.tuberculosis_H37Rv AQYGEMWAQDSAAMYAYAGSSASASAVTP-FSTPPQIANPTAQGTQAAAV
MAV_2926|M.avium_104 AQYGEYWAQDAAAMYSYAGQSASASKVTP-FQKAPQVTNPSGQAAQSAAV
MLBr_01182|M.leprae_Br4923 AEYTEMWIQDAAAMTSYQASVLEAVGATK-AFTAPPLGVNEVGLAQEVVE
Mflv_0325|M.gilvum_PYR-GCK ADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLPGVGEAGRAAA
Mvan_0415|M.vanbaalenii_PYR-1 ADYVRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPGVGEAGRAAA
MSMEG_0619|M.smegmatis_MC2_155 ADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPGVGEAGSASA
MAB_4783|M.abscessus_ATCC_1997 ADYIRMWIQAATVMSTYQAVSESSVSAAPPTSPAPPVLSPDSGAAART--
TH_3113|M.thermoresistible__bu ADYARMWIQAATTMATYEAVASAAVSATPRTVAPPPILGAGTGESATAAI
*:* . * * ::.* * . : .* : : .
MMAR_2671|M.marinum_M SAAQATSAASTQSTVQSFLSQITSQLGQLASPSGTQSFVSQLG-ASNPIL
MUL_3087|M.ulcerans_Agy99 SAAQATSAASTQSTVQSFLSQITSQLGQLASPSGTQSFVSQLG-ASNPIL
Mb1817|M.bovis_AF2122/97 ATAAGTAQST--------LTEMITGL-----PNALQSLTSPLLQSSNGPL
Rv1789|M.tuberculosis_H37Rv ATAAGTAQST--------LTEMITGL-----PNALQSLTSPLLQSSNGPL
MAV_2926|M.avium_104 STATANSTSTNTTKALQSLAQPASSS-----TTATKAATTAASTTSTDPL
MLBr_01182|M.leprae_Br4923 EVVEEVVEEVVEAEQAISQAALDQAVNEGMEATVVPQVDQQVNVDVATPQ
Mflv_0325|M.gilvum_PYR-GCK DMSAFAAQPMAAQAGAAFDVSNIIADIIRLYGEVLRFLFEPIFNFLRDPI
Mvan_0415|M.vanbaalenii_PYR-1 DVTAFAAQAQAAEAGSALDLSNIIADLIRAYGELLRFLFEPIFDFLRDPL
MSMEG_0619|M.smegmatis_MC2_155 SVQQMSAQATAAESGSSLDLSSIISDLLNQYLQGVPGG-QAILDFLKDPL
MAB_4783|M.abscessus_ATCC_1997 -----AAQDATKPPPIVPDPNDPIEMLLKNS-QHFLGMYRALKGLITDPV
TH_3113|M.thermoresistible__bu TGAHVTAELRAAESRTLLDEINELIDRLFAP----LFPPGFADALPDGLL
MMAR_2671|M.marinum_M TEIWFLLTGQT-VLPNNLGTFMQGYSNYASFFY-----------------
MUL_3087|M.ulcerans_Agy99 TEIWFLLTGQT-VLPNNLGTFMQGYSNYASFFY-----------------
Mb1817|M.bovis_AF2122/97 SWLWQILFGTP-NFPTSISALLTDLQPYASFFY-----------------
Rv1789|M.tuberculosis_H37Rv SWLWQILFGTP-NFPTSISALLTDLQPYASFFY-----------------
MAV_2926|M.avium_104 SEIWFLLTGQT-TLPTSLGSAVNGYSPFASLFY-----------------
MLBr_01182|M.leprae_Br4923 TAVPDSSSAAAPQLWGGFAQHLSPINDTLSMIN-----------------
Mflv_0325|M.gilvum_PYR-GCK GNTFALITDFLTNPVQALITWGPFLLAVVYQA----VSWVGASILYPSLF
Mvan_0415|M.vanbaalenii_PYR-1 GNTIKLITDFLTNPAQALITWGPFLAAVAYQA----VSWVGASILYPSLL
MSMEG_0619|M.smegmatis_MC2_155 GNLGRLLTDFMTNPAGALATWWPFLFGVAYQVFFNLVGWPTWGMIFASPF
MAB_4783|M.abscessus_ATCC_1997 GTIVRIIIDFSTNPAAAIVTWTPLFYVFAYAA-----TFAVMGTPIYAAI
TH_3113|M.thermoresistible__bu GTLLAPLLPGATGDGPPMATIMSFLLMGLSNP---AYLFPVLVYLLFTGV
:
MMAR_2671|M.marinum_M ------------------------------NTEGLPYFSVGMGNFGVQMA
MUL_3087|M.ulcerans_Agy99 ------------------------------NTEGLPYFSVGMGNFGVQMA
Mb1817|M.bovis_AF2122/97 ------------------------------NTEGLPYFSIGMGNNFIQAA
Rv1789|M.tuberculosis_H37Rv ------------------------------NTEGLPYFSIGMGNNFIQSA
MAV_2926|M.avium_104 ------------------------------NTEGLPYFSTGMANTFTQIA
MLBr_01182|M.leprae_Br4923 ------------------------------NHAGMANAGLSLVNGMGSAM
Mflv_0325|M.gilvum_PYR-GCK LLPLLATT--LAIVAGVGQHLLSLLNTPPAEEAAEEPAPAQSAPSRPDQQ
Mvan_0415|M.vanbaalenii_PYR-1 LLPLVATT--LAIVLGVGAYLLENLPAPAEDAPAEEPAASSPAPTRADQP
MSMEG_0619|M.smegmatis_MC2_155 LIPALAALGITGLVLLIDHVLNNPVDVPAEDEAPQEVAAAP----RTDQP
MAB_4783|M.abscessus_ATCC_1997 MGPAAGISIPLAITLAS---LSQMPEAPPVDAPAETVPARIDQPHAVAMG
TH_3113|M.thermoresistible__bu VHTTVAVSGMLAQLVPLMPALLPVAVAALGGLAGVWAGLSGLAGLAGLTA
MMAR_2671|M.marinum_M KTLGLITQPAAAAAAALP-KVPGLGGALGAIGSAGSQVAAG----LGSGA
MUL_3087|M.ulcerans_Agy99 KTLGLITQPAAAAAAALP-KVPGLGGALGAIGSAGSQVAAG----LGSGA
Mb1817|M.bovis_AF2122/97 KTLGLIGSAAPAAVAAAGDAAKGLPGLGGMLG--GGPVAAG----LGNAA
Rv1789|M.tuberculosis_H37Rv KTLGLIGSAAPAAVAAAGDAAKGLPGLGGMLG--GGPVAAG----LGNAA
MAV_2926|M.avium_104 KSVGAIGGAAPAAAKAL----PGLGGLGGMLG--GGAAAAHPVAALGGAG
MLBr_01182|M.leprae_Br4923 KSLAPTTTKAAESAFKAMGSAVQSTGRGLLGSSSGGHVTAQ----LGRAA
Mflv_0325|M.gilvum_PYR-GCK SFPATMSAPPPPSGAPIAANTVSAGSPPAPGAPAAAAATFVPYVVAGRDP
Mvan_0415|M.vanbaalenii_PYR-1 SPAIAVSAPPPPSSAAATVGTVATGTAPAPGAPAAATASFVPYAVAGRDP
MSMEG_0619|M.smegmatis_MC2_155 -LAVGISPAGVPGSAATAAAPAPAPAGTTVAAPAPAAATFVPYAVANRDP
MAB_4783|M.abscessus_ATCC_1997 GAPAPTASTAAP--TPTTTSPATPGSAPAP-TPPPAGAEGLGYAVRGDGP
TH_3113|M.thermoresistible__bu VPAADGGASAAPVPAGGPSLPSGSSAPPAPTGSAAPTTGTAPGGAGSPPP
. .
MMAR_2671|M.marinum_M HVG-HLAVPASWPG-ASVAEAVRPTVQAVSEPITSPEAA----NVIGG--
MUL_3087|M.ulcerans_Agy99 HVG-HLAVPASWPG-ASVAEAVRPTVQAVSEPITSPEAA----NVIGG--
Mb1817|M.bovis_AF2122/97 SVG-KLSVPPVWSGPLPGSVTPGAAPLPVSTVSAAPEAA--PGSLLGG--
Rv1789|M.tuberculosis_H37Rv SVG-KLSVPPVWSGPLPGSVTPGAAPLPVSTVSAAPEAA--PGSLLGG--
MAV_2926|M.avium_104 SIGGKLSVPVAWSG-APATPALGHA-IPVSSISAAPEAAGGPGNLLGG--
MLBr_01182|M.leprae_Br4923 SIG-SLRVPQTWTTASQPVTAATRALSPARVAVATESES---APLLGGGL
Mflv_0325|M.gilvum_PYR-GCK YEGFSPTVRDSTGAKAPAGTIPAAASGIAASAAERRKRRRRQKEEIKG--
Mvan_0415|M.vanbaalenii_PYR-1 GTGFSPTVRDSTSAKAPASGIPAAASGVAASAAERRKRRRRQKDEIAG--
MSMEG_0619|M.smegmatis_MC2_155 GEGFTPTLGNKSQVAAPASGVPAAASGVAASLASRRKRRRKKGAQIEE--
MAB_4783|M.abscessus_ATCC_1997 GFGFGPTIGASTGATAHAPSSAVSAAAALACNPATGKSRRRRRRTIDD--
TH_3113|M.thermoresistible__bu AGHSVPPAPHSAPPVGTSGPPYLIAAQPAPGVARRSAGARRAASIVEP--
: :
MMAR_2671|M.marinum_M ----MPVGATGAGRGVGSGPRYGFKPTVMARPLPAG--------------
MUL_3087|M.ulcerans_Agy99 ----MPVGATGAGRGVGSGPRYGFKPTVMARPLPAG--------------
Mb1817|M.bovis_AF2122/97 ----LPLAGAGGAG---AGPRYGFRPTVMARPPFAG--------------
Rv1789|M.tuberculosis_H37Rv ----LPLAGAGGAG---AGPRYGFRPTVMARPPFAG--------------
MAV_2926|M.avium_104 ----MPLAGAGAGGHGAAGPKYGFRPTVMARPPFAG--------------
MLBr_01182|M.leprae_Br4923 PMAPMVPGGGSGTGGVNTALRLQPRAFVMPRNPAAG--------------
Mflv_0325|M.gilvum_PYR-GCK --RGYADAYADYEELPDDGPPEQPAPRVTASTRGAGPMGFAGTVSRG-DE
Mvan_0415|M.vanbaalenii_PYR-1 --RAYADAYADYEPEPDDEPPVRQEPRIAATERGAGPMGFAGTVSRD-AA
MSMEG_0619|M.smegmatis_MC2_155 --RGYADAYMDYEE-PDEDPAPQPEPRVRASERGSDAMGFTGTVTRH-DV
MAB_4783|M.abscessus_ATCC_1997 --RGYRHEYATMDDHTPTGP--QDPVTAVASGTGAGRLGFAGVHTATTAV
TH_3113|M.thermoresistible__bu --AGSAAAAAAARESAPIRRRRGQKDGLHGHRHEHQQPASMSAATAP---
MMAR_2671|M.marinum_M --------------------------------------------------
MUL_3087|M.ulcerans_Agy99 --------------------------------------------------
Mb1817|M.bovis_AF2122/97 --------------------------------------------------
Rv1789|M.tuberculosis_H37Rv --------------------------------------------------
MAV_2926|M.avium_104 --------------------------------------------------
MLBr_01182|M.leprae_Br4923 --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK QAGGLTTLAGDSFGGGPREPMLPGTWDPDATDDRHTDGRDGHDGHDGKEK
Mvan_0415|M.vanbaalenii_PYR-1 QAGGLTTLPGDPFGGGPKAPMLPGTWDPDTEPD------ERHNHHDGKDS
MSMEG_0619|M.smegmatis_MC2_155 TAAGLTTLTGDTFDDRPVTPMLPGTWDGDENPAP------SPDDPEGGPR
MAB_4783|M.abscessus_ATCC_1997 EATGLSTLDGDAEN--RTIPMLPGTWDVTDDDR-----------------
TH_3113|M.thermoresistible__bu SAAGIRVLGGAGRISRTRGSVPHAEITPGDPTEPSSPTDRAHRPAEPN--
MMAR_2671|M.marinum_M -
MUL_3087|M.ulcerans_Agy99 -
Mb1817|M.bovis_AF2122/97 -
Rv1789|M.tuberculosis_H37Rv -
MAV_2926|M.avium_104 -
MLBr_01182|M.leprae_Br4923 -
Mflv_0325|M.gilvum_PYR-GCK P
Mvan_0415|M.vanbaalenii_PYR-1 Q
MSMEG_0619|M.smegmatis_MC2_155 R
MAB_4783|M.abscessus_ATCC_1997 -
TH_3113|M.thermoresistible__bu -