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MTASVWIAWPPEVLSGALWSGSGPGPLFTAAAAWGSLGAEYATAAEELAAELAGMQVGAWQGPGAESCMA AYLPYLQWLAQNSTVCGESAAQLEIVATAYISALAAMPTLTELAANHTTHAVLLGTNFFGINTIPIALNE ADYVRMWVQAATTMGVYDAISAVALGSAPHNSPAPVILKDREMGPAGSAGSTAALGGAEVIGSIWSWIVG MLVWVWQGILEVAYLGITVAFLFWEFFIPLLLSLLQGLLGLIGGLLSAIGGFLADWVPFLLGAVVALLWN YPLATLLLVLGSSALVPLGLGAAAAITLPVALPLGIGGYVNYRDQSAPDFSGAESDTGTDRITSHPLDSD SATTDDSVDANPVEMMAPRHIPAEVAQPSREVATVAGFADTAGSPATASARGWSTSTASGIPMVPSTWAT SAVGAGQQ
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_2650 | - | - | 100% (428) | PPE family protein |
| M. marinum M | MMAR_5277 | - | 1e-72 | 41.08% (443) | PPE family protein |
| M. marinum M | MMAR_3005 | - | 3e-70 | 40.94% (425) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3047c | PPE47 | 3e-64 | 37.90% (438) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0325 | - | 1e-64 | 40.55% (402) | PPE protein |
| M. tuberculosis H37Rv | Rv3018c | PPE46 | 8e-63 | 36.09% (435) | PPE family protein |
| M. leprae Br4923 | MLBr_01828 | PPE | 4e-50 | 49.04% (208) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_4783 | - | 6e-57 | 36.70% (436) | PPE family protein |
| M. avium 104 | MAV_4867 | - | 6e-63 | 40.88% (411) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 2e-65 | 38.65% (445) | PPE family protein |
| M. thermoresistible (build 8) | TH_3569 | - | 5e-62 | 41.14% (333) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_3127 | - | 0.0 | 99.07% (428) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 2e-64 | 40.32% (439) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_2650|M.marinum_M ----------MTA---SVWIAWPPEVLSGALWSGSGPGPLFTAAAAWGSL
MUL_3127|M.ulcerans_Agy99 ----------MTA---SVWIAWPPEVLSSALWSGSGPGPLFTAAAAWGSL
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTS---PVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSL
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSS---PVWMALPPEVHSALLSSGPGPGSMLAAAATWQSL
MSMEG_0619|M.smegmatis_MC2_155 ----------MTA---PIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSL
TH_3569|M.thermoresistible__bu ---------MMTA---PIWMALPPEVHSALLSSGPGPGSLLAAASAWHAL
MAB_4783|M.abscessus_ATCC_1997 ----------MTA---PVWMAAPPEVHSALLSSGPGPGSLFAAADAWRSL
MAV_4867|M.avium_104 ----------MTSPFGPIWMASPPEVHSALLSAGPGPGPLLAAAGAWTSL
Mb3047c|M.bovis_AF2122/97 ----------MTA---PVWLASPPEVHSALLSAGPGPGSLQAAAAGWSAL
Rv3018c|M.tuberculosis_H37Rv ----------MTA---PVWLASPPEVHSALLSAGPGPGSLQAAAAGWSAL
MLBr_01828|M.leprae_Br4923 ----------MSA---PIWMASPPEVHSALLSRGPGSGPLLVAAEAWRSL
::: .:*:* **** * * *.*.*.: .*. * :*
MMAR_2650|M.marinum_M GAEYATAAEELAAELAGMQVGAWQGPGAESCMAAYLPYLQWLAQNSTVCG
MUL_3127|M.ulcerans_Agy99 GAEYATAAEELAAELAGMQVGAWQGPGAESCMAAYLPYLQWLAQNSTVCG
Mflv_0325|M.gilvum_PYR-GCK SAEYASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSA
Mvan_0415|M.vanbaalenii_PYR-1 SAEYAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGA
MSMEG_0619|M.smegmatis_MC2_155 SAEYAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSA
TH_3569|M.thermoresistible__bu SAEYASAAAELSSVLANVQAGSWEGPSAERYVAAHAPYLAWLTQQSANSA
MAB_4783|M.abscessus_ATCC_1997 STEYSSAANELTTTLGSVRAGVWDGASAEQYQTAHVPYLSWLHETSAVSA
MAV_4867|M.avium_104 SAQYATAAAELSALLGEAQAGSWEGESAAQYAAAHLPYLAWLQQASADSA
Mb3047c|M.bovis_AF2122/97 SAEYAAVAQELSAVVAAVGAGVWQGPSAELFVAAYVPYVAWLVQASADSA
Rv3018c|M.tuberculosis_H37Rv SAEYAAVAQELSVVVAAVGAGVWQGPSAELFVAAYVPYVAWLVQASADSA
MLBr_01828|M.leprae_Br4923 SSVYAEMADELVALLVVVPVSSWDGSAAEAYVIAYLPYLGWLRQASVDSA
.: *: * ** : . *:* .: *: **: ** : *. .
MMAR_2650|M.marinum_M ESAAQLEIVATAYISALAAMPTLTELAANHTTHAVLLGTNFFGINTIPIA
MUL_3127|M.ulcerans_Agy99 ESAAQLEIVATAYISALAAMPTLTELAANHTTHAVLLGTNFFGINTIPIA
Mflv_0325|M.gilvum_PYR-GCK ATAVQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIA
Mvan_0415|M.vanbaalenii_PYR-1 AAAAQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIA
MSMEG_0619|M.smegmatis_MC2_155 AAAVQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIA
TH_3569|M.thermoresistible__bu ATAGRHETAAAAYSTALATMPTMAELTLNKTTHAVLVATNFLGINTIPIA
MAB_4783|M.abscessus_ATCC_1997 GVAAQTETAATAYSEALATMPTLGELAANHATHGALVATNFFGINTIPIA
MAV_4867|M.avium_104 GAAAQQEVAATAYTTALAAMPTLAELAANHTIHGVLLATNFFGINTIPIA
Mb3047c|M.bovis_AF2122/97 AAAGEHEAAAAGYVCALAEMPTLPELAANHLTHAVLVATNFFGINTIPIA
Rv3018c|M.tuberculosis_H37Rv AAAGEHEAAAAGYVCALAEMPTLPELAANHLTHAVLVATNFFGINTIPIA
MLBr_01828|M.leprae_Br4923 VMAAHYETMATAYITTLAMMPTLAELAANRTAHTVLVTTNFFGINTIPIA
* . : *:.* :** ***: **: *: * .*: ***:********
MMAR_2650|M.marinum_M LNEADYVRMWVQAATTMGVYDAISAVALGSAPHNSPAPVILKDREMGPAG
MUL_3127|M.ulcerans_Agy99 LNEADYVRMWVQAATTMGVYDAISAVALGSAPHNSPAPVILKDREMGPAG
Mflv_0325|M.gilvum_PYR-GCK LNEADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLPGVGEAGR
Mvan_0415|M.vanbaalenii_PYR-1 MTEADYVRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPGVGEAGR
MSMEG_0619|M.smegmatis_MC2_155 LNEADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPGVGEAGS
TH_3569|M.thermoresistible__bu LNEADYVRMWIQAATSMSTYQAVAGTAVMSAPASSPAPLLLAPGVSEAAD
MAB_4783|M.abscessus_ATCC_1997 VNEADYIRMWIQAATVMSTYQAVSESSVSAAPPTSPAPPVLSPDSGAAAR
MAV_4867|M.avium_104 VNEADYARMWVQAATTMGTYQAVAGSALAAAPRTAPAPSIVKPG-GEANN
Mb3047c|M.bovis_AF2122/97 LNEADYVRMWVQAATVMSAYEAVVGAALVATPHTGPAPVIVKPGANEASN
Rv3018c|M.tuberculosis_H37Rv LNEADYVRMWVQAATVMSAYEAVVGAALVATPHTGPAPVIVKPGANEASN
MLBr_01828|M.leprae_Br4923 RNEIDYVRMWVEAAIAMGTYQEVSTVVVDSAPEAIAAPQIMASDALEASS
.* ** ***::** *..*: : : ::* .** :: .
MMAR_2650|M.marinum_M SAG-----------------------------STAALGGAEVIGSIWSWI
MUL_3127|M.ulcerans_Agy99 SAG-----------------------------STAALGGAEVIGSIWSWI
Mflv_0325|M.gilvum_PYR-GCK AAADMSAFAA--------------------QPMAAQAGAAFDVSNIIADI
Mvan_0415|M.vanbaalenii_PYR-1 AAADVTAFAA--------------------QAQAAEAGSALDLSNIIADL
MSMEG_0619|M.smegmatis_MC2_155 ASASVQQMSA--------------------QATAAESGSSLDLSSIISDL
TH_3569|M.thermoresistible__bu AMATTQQIGS--------------------QATAADSGTALNLSDLIANL
MAB_4783|M.abscessus_ATCC_1997 TAA---------------------------QDATKPPPIVPDPNDPIEML
MAV_4867|M.avium_104 LAAN-----------------------------AAQNSS----GDWWQNF
Mb3047c|M.bovis_AF2122/97 AVA----------------------------AATITPFPFGELAKFLEMA
Rv3018c|M.tuberculosis_H37Rv AVA----------------------------AATITPFPWHEIVQFLEET
MLBr_01828|M.leprae_Br4923 DQPSPTAPSQSPQVQNWLQWLQKIGYTDFYNTLVQPLITSLTNHPFFQGM
.
MMAR_2650|M.marinum_M VG---------------------------------MLVWVWQGILEVAYL
MUL_3127|M.ulcerans_Agy99 VG---------------------------------MLVWVWQGILEVAYL
Mflv_0325|M.gilvum_PYR-GCK IRLYGEVLRFLFEPIFNF--------------LRDPIGNTFALITDFLTN
Mvan_0415|M.vanbaalenii_PYR-1 IRAYGELLRFLFEPIFDF--------------LRDPLGNTIKLITDFLTN
MSMEG_0619|M.smegmatis_MC2_155 LNQYLQGVPGGQ-AILDF--------------LKDPLGNLGRLLTDFMTN
TH_3569|M.thermoresistible__bu LQYYQDYLDQLFGPIVDF--------------LRDPIGNLFQLIDDFLTN
MAB_4783|M.abscessus_ATCC_1997 LKNSQHFL-GMYRALKGL--------------ITDPVGTIVRIIIDFSTN
MAV_4867|M.avium_104 IQQLSQFF-----------------------------QNIQKMLQDFWAN
Mb3047c|M.bovis_AF2122/97 AQAFTEVG--------------------------ELIMKSAEAWAVGFVE
Rv3018c|M.tuberculosis_H37Rv FAAYDQYL--------------------------SALLSELPAVAWVWFQ
MLBr_01828|M.leprae_Br4923 FSGFDPWLPSLGNPLSFLSPFNIAFALGTPMDIGSYVGYLSQTFAFIGAD
MMAR_2650|M.marinum_M GITVAFLFWEFFIPLLLSLLQGLLGLIGGLLSAIGGFLADWVPFLLGAVV
MUL_3127|M.ulcerans_Agy99 GVTVAFLFWEFFIPLLLSLLQGLLGLIGGLLSAIGGFLADWVPFLLGAVV
Mflv_0325|M.gilvum_PYR-GCK PVQALITWGPFLLAVVYQAVSWVGASILYPSLFLLPLLATTLAIVAGVGQ
Mvan_0415|M.vanbaalenii_PYR-1 PAQALITWGPFLAAVAYQAVSWVGASILYPSLLLLPLVATTLAIVLGVGA
MSMEG_0619|M.smegmatis_MC2_155 PAGALATWWPFLFGVAYQVFFNLVGWPTWGMIFASPFLIPALAALGITGL
TH_3569|M.thermoresistible__bu PAGALVTWWPLLFAVAYQVFTNLVGWPTWAMILASPVLIPLAITLGVAGL
MAB_4783|M.abscessus_ATCC_1997 PAAAIVTWTPLFYVFAYAATFAVMGTPIYAAIMGP---AAGISIPLAITL
MAV_4867|M.avium_104 LPAFLAANGPLLFFVAYQVFFNAVGWPTWGAILTAP---FLLPLLLGIGL
Mb3047c|M.bovis_AF2122/97 LITGLVNFEPWLVLTGMIDMFFATVGFALGVFVLVPLLEFAVVLELAILS
Rv3018c|M.tuberculosis_H37Rv LFVDILGFNIIGFIITLASNAQLLTEFAINASYVAVGLLYAIAGVIDIV-
MLBr_01828|M.leprae_Br4923 LAAAFASGNPVTIGFTLLFTTIEAIGTIITDTIALVKTMIEQSFVLLPMI
MMAR_2650|M.marinum_M ALLWNYPLATLLLVLGSSALVPLGLGAAAA-----------------ITL
MUL_3127|M.ulcerans_Agy99 ALLWNYPLATLLLVLGSSALVPLGLGAAAT-----------------ITL
Mflv_0325|M.gilvum_PYR-GCK HLLSLLNTP-PAEEAAEEPAPAQSAPSRPDQQSFPATMSAPPPPSGAPIA
Mvan_0415|M.vanbaalenii_PYR-1 YLLENLPAP-AEDAPAEEPAASSPAPTRADQPSPAIAVSAPPPPSSAAAT
MSMEG_0619|M.smegmatis_MC2_155 VLLIDHVLNNPVDVPAEDEAPQEVAAAPRTDQPLAVGISPAGVPGSAATA
TH_3569|M.thermoresistible__bu VMIADQAQP-----PAEEAAPEEDVAAP-------------------VRA
MAB_4783|M.abscessus_ATCC_1997 ASLSQMPEAPPVDAPAETVPARIDQPHAVAMGGAPAPTASTAAP--TPTT
MAV_4867|M.avium_104 SSLLAAPAEIAPVAAPAAITPVLASNKPPTLPAAVALAPSVATPAGAPAS
Mb3047c|M.bovis_AF2122/97 IGWIISNIFGAIPVLAGPLLGALAAAVVPG----------------VAGV
Rv3018c|M.tuberculosis_H37Rv VEWVIGNLFGVVPLLGGPLLGALAAAVVPG----------------VAGL
MLBr_01828|M.leprae_Br4923 LPLLTAPLAVATAGAAGSFAGLSELAGLVGVAPPGLPSAPPVAAVAPVVP
MMAR_2650|M.marinum_M PVALPLGIGGYVNYRDQSAPDFSGAESDTG-------TDRI---------
MUL_3127|M.ulcerans_Agy99 PVALPLGIGGYVNYREQSAPDFSGAESDTG-------TDRI---------
Mflv_0325|M.gilvum_PYR-GCK ANTVSAGSPPAPGAPAAAAATFVPYVVAGRDPYEGFSPTVR---------
Mvan_0415|M.vanbaalenii_PYR-1 VGTVATGTAPAPGAPAAATASFVPYAVAGRDPGTGFSPTVR---------
MSMEG_0619|M.smegmatis_MC2_155 AAPAPAPAGTTVAAPAPAAATFVPYAVANRDPGEGFTPTLG---------
TH_3569|M.thermoresistible__bu EPQNPLPLTXXX--------------------------------------
MAB_4783|M.abscessus_ATCC_1997 TSPATPGSAPAP-TPPPAGAEGLGYAVRGDGPGFGFGPTIG---------
MAV_4867|M.avium_104 TVAAGSGAAAAP-GPAAAAGNFAYLVAFGGDPDTGVGPTLS---------
Mb3047c|M.bovis_AF2122/97 TGLAGLAAVPAVGAAAGAPAALVGSVAP----------------------
Rv3018c|M.tuberculosis_H37Rv AGVAGLAALPAVGAAAGAPAALVGSVAP----------------------
MLBr_01828|M.leprae_Br4923 PSMPTLASIPTPTPMPAPAASTAPVVTPPGPPPVTAPPSVTGAGVESFGY
MMAR_2650|M.marinum_M TSHPLDSDSATTDDSVDANPVEMMAPR-----------------------
MUL_3127|M.ulcerans_Agy99 TSHPLDSDSATTDDSVDANPVEMMAPR-----------------------
Mflv_0325|M.gilvum_PYR-GCK DSTGAKAPAGTIPAAASGIAASAAERRKRRRRQKEEIKGRGYADAYADYE
Mvan_0415|M.vanbaalenii_PYR-1 DSTSAKAPASGIPAAASGVAASAAERRKRRRRQKDEIAGRAYADAYADYE
MSMEG_0619|M.smegmatis_MC2_155 NKSQVAAPASGVPAAASGVAASLASRRKRRRKKGAQIEERGYADAYMDYE
TH_3569|M.thermoresistible__bu --------------------------------------------------
MAB_4783|M.abscessus_ATCC_1997 ASTGATAHAPSSAVSAAAALACNPATGKSRRRRRRTIDDRGYRHEYATMD
MAV_4867|M.avium_104 GRGGAKAPAATIPAAGAAAPARAEARARRRRRAALHDYSDEFLDMDSGFG
Mb3047c|M.bovis_AF2122/97 VSGGVVSPQARLVSAVEPAPASTSVS------------------------
Rv3018c|M.tuberculosis_H37Rv VSGGVVSPQARLVSAVEPAPASTSVS------------------------
MLBr_01828|M.leprae_Br4923 LVGRLPSTARGVVGTSVRQQSSAPDRIEAPDAAATPQEQARSRWRRRAKV
MMAR_2650|M.marinum_M --------HIPAEVAQPSREVATVAGFADTAGSPATASARGWSTST----
MUL_3127|M.ulcerans_Agy99 --------HIPAEVAQPSREVATVAGFADTAGSPATASARGWSTST----
Mflv_0325|M.gilvum_PYR-GCK ELPDDGPPEQPAPRVTASTRGAGPMGFAGTVSRG-DEQAGGLTTLAGDSF
Mvan_0415|M.vanbaalenii_PYR-1 PEPDDEPPVRQEPRIAATERGAGPMGFAGTVSRD-AAQAGGLTTLPGDPF
MSMEG_0619|M.smegmatis_MC2_155 E-PDEDPAPQPEPRVRASERGSDAMGFTGTVTRH-DVTAAGLTTLTGDTF
TH_3569|M.thermoresistible__bu --------------------------------------------------
MAB_4783|M.abscessus_ATCC_1997 DHTPTGP--QDPVTAVASGTGAGRLGFAGVHTATTAVEATGLSTLDGDAE
MAV_4867|M.avium_104 VPPDYGAEEELAA-AVASGQGAGTLGFAGTQQRRKAFQAAGLTKLADDDF
Mb3047c|M.bovis_AF2122/97 --------------VLASDRGAGALGFVGTAGKESVGQPAGLTVLA-DEF
Rv3018c|M.tuberculosis_H37Rv --------------VLASDRGAGALGFVGTAGKESVGQPAGLTVLA-DEF
MLBr_01828|M.leprae_Br4923 TPFDSSGSPNPKAAPTASDQGAGTLGLAGTARQASSGPATGLVTLSNGTF
MMAR_2650|M.marinum_M --ASGIPMVPSTWATSAVGA-------------GQQ--
MUL_3127|M.ulcerans_Agy99 --ASGIPMVPSTWATSAVGA-------------GQQ--
Mflv_0325|M.gilvum_PYR-GCK GGGPREPMLPGTWDPDATDDRHTDGRDGHDGHDGKEKP
Mvan_0415|M.vanbaalenii_PYR-1 GGGPKAPMLPGTWDPDTEPD------ERHNHHDGKDSQ
MSMEG_0619|M.smegmatis_MC2_155 DDRPVTPMLPGTWDGDENPA------PSPDDPEGGPRR
TH_3569|M.thermoresistible__bu --------------------------------------
MAB_4783|M.abscessus_ATCC_1997 N--RTIPMLPGTWDVTDDDR------------------
MAV_4867|M.avium_104 GGSPRMPMVPGTWEQDTQNG-------AHPTEPGKGG-
Mb3047c|M.bovis_AF2122/97 GDGAPVPMLPGSWGPDLVGV---------AGDGGLVSV
Rv3018c|M.tuberculosis_H37Rv GDGAPVPMLPGSWGPDLVGV---------AGDGGLVSV
MLBr_01828|M.leprae_Br4923 SDSPRAPMLPRTWGADPTFCYN---AADIGPAGGWDDE