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VSFWMWPPEVNSVLLLDGPGPGPMLEAAAAWDGIGTELSAAASAFGSVTSELAGQAWQGPASASMRAAAV RYLDWLGGTAAQAEQSATQARAAAVAYEAALATIVDPGLIVANRGQLVSLAFSNLFGQNAPAIAAAEAAY EQMWAQDVAAMGGYYSSASATVAALGPWARALENLPGEFARALDNGLVLVEQEIEQAATTLATEFTQVSN TLFTTIFGAPADPPFAASQTGTFTGTPSLITRFENTALLPLKPLLSVSGLDSQIAVPGNPLLALVASDIP PLSWFIGNSPPPLLNLLLGETVQYSTYDGMSVVQITPAHPTGDYVVAIHGGAFIFPPSFLHWINYSVMAH QTGATVQVPIYPLLQEGGTAGTVVPAMAGLISNQIMQHGAANVSVIGDSAGGNLALGAVEYMASQGSQVP SSMVLLSPWLDLGMTNPNIAFVQDPLLPFGPAQQIGKAWAGNLAVTDPMVSPLYGSLSGLPPTYVYAGSQ EILAPDVLVLQQEAAAIGAPFNFVLAHGQIHDWVLLTLDGPRYLAQINQELGIAA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_1547 | - | - | 100% (545) | PE-PGRS family protein |
| M. marinum M | MMAR_4319 | - | 3e-55 | 56.99% (186) | PPE family protein |
| M. marinum M | MMAR_4218 | - | 1e-54 | 58.76% (177) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3124c | PE_PGRS63 | 1e-139 | 57.69% (468) | PE-PGRS family protein |
| M. gilvum PYR-GCK | Mflv_4426 | - | 4e-61 | 35.25% (505) | alpha/beta hydrolase domain-containing protein |
| M. tuberculosis H37Rv | Rv3097c | lipY | 1e-138 | 57.48% (468) | triacylglycerol lipase |
| M. leprae Br4923 | MLBr_01182 | - | 3e-28 | 43.31% (157) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_0809c | - | 2e-27 | 38.79% (165) | PPE family protein |
| M. avium 104 | MAV_4704 | - | 1e-51 | 56.98% (172) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 5e-27 | 41.36% (162) | PPE family protein |
| M. thermoresistible (build 8) | TH_3113 | - | 5e-28 | 31.77% (384) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_0964 | - | 2e-54 | 56.45% (186) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_1822 | - | 4e-56 | 43.00% (293) | alpha/beta hydrolase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_4704|M.avium_104 -MTNPHFAWLPPEVNSALIYSGPGPGPLLAAAAAWDGLAEELASSAQSFS
MUL_0964|M.ulcerans_Agy99 -MN---FMMLPPEVNSALMFTGAGSAPTLAAATAWDGLVAELGEAAEAFS
MLBr_01182|M.leprae_Br4923 ---MFDFAALSPETNSTRMYLGPGSSPILTAAAAWVVLAKELTAAAQGLQ
MAB_0809c|M.abscessus_ATCC_199 MLAAPVWMASPPEVHSALLSSGPGPGPLLAAAAEWSSLGAHYSATAQELR
MSMEG_0619|M.smegmatis_MC2_155 -MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAEYAAAAAELT
TH_3113|M.thermoresistible__bu -------MALPPEVHSTLLRTGPGPGALSAAADAWRMLSDEYRAAAVELA
Mb3124c|M.bovis_AF2122/97 ------------MVSYVVALP------------------EVMSAAATDVA
Rv3097c|M.tuberculosis_H37Rv ------------MVSYVVALP------------------EVMSAAATDVA
MMAR_1547|M.marinum_M ----MSFWMWPPEVNSVLLLDGPGPGPMLEAAAAWDGIGTELSAAASAFG
Mflv_4426|M.gilvum_PYR-GCK ----MTERRIRPSIGRASAWAG------AWTVAVGAGAVIACSATAPAWA
Mvan_1822|M.vanbaalenii_PYR-1 ----MADRNK-----LVVARVG------GLAIAAGAGAVIACSAPAPAFA
.*
MAV_4704|M.avium_104 SVTSDLASGSWQGASSAAMMTVANQYVSWLSAAAAQAEEVSHQASAIATA
MUL_0964|M.ulcerans_Agy99 SVTSGLASGSWQGPAAAAMAAAAAPYAGWLSAAATRALGAATQAKAAAAV
MLBr_01182|M.leprae_Br4923 SAVEALLT-TFEGESAAALAERVTPYEKWLTQNAASAELTATQLTVAANA
MAB_0809c|M.abscessus_ATCC_199 AILAATHASAWHGPSAETYVAAHTPYLEWLNQGALESNARAVQHGAAAGA
MSMEG_0619|M.smegmatis_MC2_155 SVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAAVQHETAAAA
TH_3113|M.thermoresistible__bu AVVSQTCATAWEGVGADAYAAAHGPYLFWLTDTAAAAAAAGAQLEAAAAA
Mb3124c|M.bovis_AF2122/97 SIGSVVA-------------------------TASQGVAGATTTVLAAAE
Rv3097c|M.tuberculosis_H37Rv SIGSVVA-------------------------TASQGVAGATTTVLAAAE
MMAR_1547|M.marinum_M SVTSELAGQAWQGPASASMRAAAVRYLDWLGGTAAQAEQSATQARAAAVA
Mflv_4426|M.gilvum_PYR-GCK SEDDTSAEPRTAAAAPSKP-SQDRPSR-------ASAERRADTDTGADPS
Mvan_1822|M.vanbaalenii_PYR-1 SAEDVGSSANVSTSEPSRPQSTKAPSRQDNADESAASGTSDDNDLGDDRS
: .
MAV_4704|M.avium_104 FEVALAATVQPAVVAANRALVQALAATNWLGQNTPAIADIEAAYEQMWAS
MUL_0964|M.ulcerans_Agy99 FESAQAATVHPELVLANRNQLVSLVLSNLFGQNAPAIAATESTYEELWAQ
MLBr_01182|M.leprae_Br4923 YETAFTMTVPPLMVFVNRAQACLLIMSNIFGQNSTAIAEKEAEYTEMWIQ
MAB_0809c|M.abscessus_ATCC_199 YSTALAVMPTLAELAANHATHAALVATNFFGINTIPILATEADYVRMWVQ
MSMEG_0619|M.smegmatis_MC2_155 YSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNEADYVRMWIQ
TH_3113|M.thermoresistible__bu HASALAAMPTMAELTANRTTHAALVATNFFGVNTIPIAVNEADYARMWIQ
Mb3124c|M.bovis_AF2122/97 DEVSAA---------------IAALFS-AHGQDYQALSAQLAVFHERFVQ
Rv3097c|M.tuberculosis_H37Rv DEVSAA---------------IAALFS-GHGQDYQALSAQLAVFHERFVQ
MMAR_1547|M.marinum_M YEAALATIVDPGLIVANRGQLVSLAFSNLFGQNAPAIAAAEAAYEQMWAQ
Mflv_4426|M.gilvum_PYR-GCK ETRVSLRPS-------------RTRATDGDGGDPDTTTVELAVAD---EP
Mvan_1822|M.vanbaalenii_PYR-1 DESAASGTSDDN----DLGDDRSDEAEEPRHSDETVTDEEEAVADQEVAT
: :
MAV_4704|M.avium_104 DVAAMFGYHADASAAVAKLP----------PWNEVLQNLGFSNASTAVTR
MUL_0964|M.ulcerans_Agy99 DVAATVGYHGGASAVAAQLA----------PWQQAIQALPGRVAAMATTG
MLBr_01182|M.leprae_Br4923 DAAAMTSYQASVLEAVGATK----------AFTAPPLGVNEVGLAQEVVE
MAB_0809c|M.abscessus_ATCC_199 AATTMATYQTASEVALASAP----------PSTPPPSILH----DHDHGH
MSMEG_0619|M.smegmatis_MC2_155 AATTMSTYQAVSGAAVAAAP----------VSAPAPFLLKPGVGEAGSAS
TH_3113|M.thermoresistible__bu AATTMATYEAVASAAVSATP----------RTVAPPPILGAGTGESATAA
Mb3124c|M.bovis_AF2122/97 ALTGAAKGYAAAELANASL---------LQSEFASGIGNGFATIHQEIQR
Rv3097c|M.tuberculosis_H37Rv ALTGAAKGYAAAELANASL---------LQSEFASGIGNGFATIHQEIQR
MMAR_1547|M.marinum_M DVAAMGGYYSSASATVAALGPWARALENLPGEFARALDNGLVLVEQEIEQ
Mflv_4426|M.gilvum_PYR-GCK SDPGDVEEPA----------------------PESPVAAPALWSLVGSAR
Mvan_1822|M.vanbaalenii_PYR-1 PDLGPVDKPAGVPSVHTIDDGFAPAGGDHATPPAGPNLSPAAWTLLGSAR
MAV_4704|M.avium_104 PAGSGAVARG----------------------------------------
MUL_0964|M.ulcerans_Agy99 PAASAAAALASGPAAALDIGNNGSGNFLSIGNIGNNNLGSGNTGSANLGG
MLBr_01182|M.leprae_Br4923 EVVEEVVEEVVEA-------------------------------------
MAB_0809c|M.abscessus_ATCC_199 DDHDHEHGHDDDH-------------------------------------
MSMEG_0619|M.smegmatis_MC2_155 ASVQQMSAQATAA-------------------------------------
TH_3113|M.thermoresistible__bu ITGAHVTAELRAA-------------------------------------
Mb3124c|M.bovis_AF2122/97 APTALAAG------FTQV--------------------------------
Rv3097c|M.tuberculosis_H37Rv APTALAAG------FTQV--------------------------------
MMAR_1547|M.marinum_M AATTLATE------FTQVSNTLFTTIFGAP--------------------
Mflv_4426|M.gilvum_PYR-GCK PQDSGDTATAAVPG------------------------------------
Mvan_1822|M.vanbaalenii_PYR-1 RDTEAAAVPPSQPD------------------------------------
MAV_4704|M.avium_104 -------------------------------------YTSRIAGFLAPRA
MUL_0964|M.ulcerans_Agy99 GNIGNGNLGSGNTGNVNLGNGNNGFFNFGNGNLGDTNFGSGNSGNLNLGS
MLBr_01182|M.leprae_Br4923 -------------------------------------EQAISQAALDQAV
MAB_0809c|M.abscessus_ATCC_199 --------------------------------------GHG---DLDPTD
MSMEG_0619|M.smegmatis_MC2_155 --------------------------------------ESGSSLDLSSII
TH_3113|M.thermoresistible__bu --------------------------------------ESRTLLDEINEL
Mb3124c|M.bovis_AF2122/97 --------------------------------PPFAAAQAGIFTGTPSGA
Rv3097c|M.tuberculosis_H37Rv --------------------------------PPFAAAQAGIFTGTPSGA
MMAR_1547|M.marinum_M ------------------------------ADPPFAASQTGTFTGTPSLI
Mflv_4426|M.gilvum_PYR-GCK ------------------------------TATEAPPTADTTDTDTVPAA
Mvan_1822|M.vanbaalenii_PYR-1 ------------------------------TTSETVNTDAAAATDPATAV
MAV_4704|M.avium_104 PQ------------------------------------------------
MUL_0964|M.ulcerans_Agy99 GNRFGSGNIGFGNRFGDGNFGSGN--AGSYNFGTGNNGSFNIGSGNNGDS
MLBr_01182|M.leprae_Br4923 NEGMEATVVPQVDQQVNVDVATPQ--TAVP--------------------
MAB_0809c|M.abscessus_ATCC_199 P----EWWVHVAG------------------------EMVEHFELLLNNL
MSMEG_0619|M.smegmatis_MC2_155 SDLLNQYLQGVPGGQAILDFLK---------------DPLGNLGRLLTDF
TH_3113|M.thermoresistible__bu IDRLFAPLFPPGFADALPDGLLGTLLAPLLPGATGDGPPMATIMSFLLMG
Mb3124c|M.bovis_AF2122/97 AGFDIASLWPVKPLLSLSALETHFAIPNNPLLALIASDIPPLSWFLGNSP
Rv3097c|M.tuberculosis_H37Rv AGFDIASLWPVKPLLSLSALETHFAIPNNPLLALIASDIPPLSWFLGNSP
MMAR_1547|M.marinum_M TRFENTALLPLKPLLSVSGLDSQIAVPGNPLLALVASDIPPLSWFIGNSP
Mflv_4426|M.gilvum_PYR-GCK A---DAPVVDQPVYTGRPSFVQQVVIAGLNVLKVVLKPFGGLLAFTSLKI
Mvan_1822|M.vanbaalenii_PYR-1 ASLKDPLGEDESRYTGKPSFVHDVVTFGLYVLKAVLKPFGGLLAFTGLKV
MAV_4704|M.avium_104 --------------------------------------------------
MUL_0964|M.ulcerans_Agy99 NIGFGNLGTNNLGFGNNGSNNIGFGLSGSNQIGIGGLNAGIGNMGFGNAG
MLBr_01182|M.leprae_Br4923 ----------------DSSSAAAPQLWGGFAQHLSPINDTLSMINN----
MAB_0809c|M.abscessus_ATCC_199 LTDPAALLTNLPMVLADVAFHAAQLASTIGQFAPALIQPALALAIANLG-
MSMEG_0619|M.smegmatis_MC2_155 MTNPAGALATWWPFLFGVAYQVFFNLVGWPTWGMIFASPFLIPALAALG-
TH_3113|M.thermoresistible__bu LSNPAYLFPVLVYLLFTGVVHTTVAVSGMLAQLVPLMPALLPVAVAALGG
Mb3124c|M.bovis_AF2122/97 PPLLN------SLLGQTVQYTTYDGMSVVQITP-AHPTGEYVVAIHGGAF
Rv3097c|M.tuberculosis_H37Rv PPLLN------SLLGQTVQYTTYDGMSVVQITP-AHPTGEYVVAIHGGAF
MMAR_1547|M.marinum_M PPLLN------LLLGETVQYSTYDGMSVVQITP-AHPTGDYVVAIHGGAF
Mflv_4426|M.gilvum_PYR-GCK PFFTDGVPPFFLTPGLDVERTEFDGMKVWSLAPRRDQTDKVVVALHGGAY
Mvan_1822|M.vanbaalenii_PYR-1 PFFTDGIPPFFLTPGLDVERSEFEGMKVWTLTPRKNATEKTVVALHGGAY
MAV_4704|M.avium_104 --------------------------------------------------
MUL_0964|M.ulcerans_Agy99 DNNVGFFNSGSNNIGFFNSGDGNFGFAHAGSTNTGFWNSGGTNTGFGNGG
MLBr_01182|M.leprae_Br4923 ---------------------------HAGMANAGLSLVNGMGSAMKSLA
MAB_0809c|M.abscessus_ATCC_199 WAAGFAGLAGIQPSPEILAVEPGSVEDAPMAASAGTALAP-SPPASAAAP
MSMEG_0619|M.smegmatis_MC2_155 ITGLVLLIDHVLNNPVDVPAEDEAPQEVAAAPRTDQPLAVGISPAGVPGS
TH_3113|M.thermoresistible__bu LAGVWAGLSGLAG----LAGLTAVPAADGGASAAPVPAGGPSLPSGSSAP
Mb3124c|M.bovis_AF2122/97 ILPPSIFHWLNYSVTAYQTGATVQVPIYPLVQEGGTAGTVVPAMAGLIST
Rv3097c|M.tuberculosis_H37Rv ILPPSIFHWLNYSVTAYQTGATVQVPIYPLVQEGGTAGTVVPAMAGLIST
MMAR_1547|M.marinum_M IFPPSFLHWINYSVMAHQTGATVQVPIYPLLQEGGTAGTVVPAMAGLISN
Mflv_4426|M.gilvum_PYR-GCK VATASIFHWWTYADMARDTGATVVVPLQTLVPRGGTAATEVPRTADFLTE
Mvan_1822|M.vanbaalenii_PYR-1 VATASIFHWWTYADMARDTGATVIVPLQTLVPAGGTAASEVPRTANFISK
MAV_4704|M.avium_104 --------------------------------------------------
MUL_0964|M.ulcerans_Agy99 SLNFGFGNGGVENMGHGNAGSFNMGFGNGGGGNTGFYNSGTYNTGFSNAA
MLBr_01182|M.leprae_Br4923 PTTTKAAESAFKAMGSAVQSTGRGLLGSSSGGHVTAQLGRAASIGSLRVP
MAB_0809c|M.abscessus_ATCC_199 AAPASAPAPTASGTAPAPPSPPPVGDPGFSFPYAVGGGPRLGTGLALAAQ
MSMEG_0619|M.smegmatis_MC2_155 AATAAAPAPAPAGTTVAAPAPAAAT----FVPYAVANRD-PGEGFTPTLG
TH_3113|M.thermoresistible__bu PAPTGSAAPTTGTAPGGAGSPPPAGHSVPPAPHSAPPVGTSGPPYLIAAQ
Mb3124c|M.bovis_AF2122/97 QIAQHGVSNVSVVGDSAGGNLALAAAQYMVSQGNPVPSSMVLLSPWLDVG
Rv3097c|M.tuberculosis_H37Rv QIAQHGVSNVSVVGDSAGGNLALAAAQYMVSQGNPVPSSMVLLSPWLDVG
MMAR_1547|M.marinum_M QIMQHGAANVSVIGDSAGGNLALGAVEYMASQGSQVPSSMVLLSPWLDLG
Mflv_4426|M.gilvum_PYR-GCK MIDAHGAHNVSVFGDSAGGGLALAAVQELNRRSAATPSRLVLLAPWLDVS
Mvan_1822|M.vanbaalenii_PYR-1 VIEDHGADNVSVIGDSAGGGLALAAIQELARRNSRNPSRLVLISPWLDVS
MAV_4704|M.avium_104 --------------------------------------------------
MUL_0964|M.ulcerans_Agy99 ETNTGWENSGNVNTGGYNSGGLNTGIGSPDTQAGPNSGFGHSGSGNSGFF
MLBr_01182|M.leprae_Br4923 QT---WTTASQPVTAATRALSPARVAVATESESAPLLGG---GLPMAPMV
MAB_0809c|M.abscessus_ATCC_199 VRRGTSAAARSSAREQAAAAETAAARQARRRRDKGKQQGRGIEYMDMNAT
MSMEG_0619|M.smegmatis_MC2_155 NKSQVAAPASGVPAAASGVAASLASRRKRRRKKGAQIEERGYADAYMDYE
TH_3113|M.thermoresistible__bu PAPGVARRSAGARRAASIVEPAGSAAAAAAARESAPIRRRRGQKDGLHGH
Mb3124c|M.bovis_AF2122/97 T------------------WQISQAWAGNLAVNDPLVSPLYGSLNGLPPT
Rv3097c|M.tuberculosis_H37Rv T------------------WQISQAWAGNLAVNDPLVSPLYGSLNGLPPT
MMAR_1547|M.marinum_M MTNPNIAFVQDPLLPFGPAQQIGKAWAGNLAVTDPMVSPLYGSLSGLPPT
Mflv_4426|M.gilvum_PYR-GCK MSDPRSAEIRDPLLDIPNLVRSGAKWAGSAGVTDPLASPLFGSLEGLPPT
Mvan_1822|M.vanbaalenii_PYR-1 MSDPRSAEIRDPLLDLANPTKSGAKWAGEAGTADPQASPLFGSLKGLPPT
MAV_4704|M.avium_104 --------------------------------------------------
MUL_0964|M.ulcerans_Agy99 NSGDGNSGFENSNTCVSANGHSGVRNSGDATNVGFSNSGSNNTGIFNTGT
MLBr_01182|M.leprae_Br4923 PGGGSGTGGVNTALRLQPRAFVMPRNPAAG--------------------
MAB_0809c|M.abscessus_ATCC_199 ARCEEPAP----DTTASHRGAGTMGFAGTVIKTGATASGLAMLSRDDDLF
MSMEG_0619|M.smegmatis_MC2_155 EPDEDPAPQPEPRVRASERGSDAMGFTGTVTRHDVTAAGLTTLTG-DTFD
TH_3113|M.thermoresistible__bu RHEHQQPASMSAATAPSAAGIRVLGGAGRISRTRGSVPHAEITPGDPTEP
Mb3124c|M.bovis_AF2122/97 YVYSGSLDPLAQQAVVLEHTAVVQGAP-FSFVLAPWQIHDWILLTPW--G
Rv3097c|M.tuberculosis_H37Rv YVYSGSLDPLAQQAVVLEHTAVVQGAP-FSFVLAPWQIHDWILLTPW--G
MMAR_1547|M.marinum_M YVYAGSQEILAPDVLVLQQEAAAIGAP-FNFVLAHGQIHDWVLLTLD--G
Mflv_4426|M.gilvum_PYR-GCK YVYSSSRDLLSVDTLRLRERVGAEGIPNVEFRLRAGLIHDWFTFPFLPDA
Mvan_1822|M.vanbaalenii_PYR-1 YVYSSSLDLLTVDTLRLRDRVLAEQVPDVEFRLRKNLIHDWFTFPFLPEA
MAV_4704|M.avium_104 -------------------------------------
MUL_0964|M.ulcerans_Agy99 FNTGIANSGSDSSGLLISGTNSSGALNSGDDQSGFNN
MLBr_01182|M.leprae_Br4923 -------------------------------------
MAB_0809c|M.abscessus_ATCC_199 EGVRAPMVPNTWD-----------PEHGRQD------
MSMEG_0619|M.smegmatis_MC2_155 DRPVTPMLPGTWDGDENPAPSPDDPEGGPRR------
TH_3113|M.thermoresistible__bu SSPTDRAHRPAEPN-----------------------
Mb3124c|M.bovis_AF2122/97 LLSWPQINQQLGIAA----------------------
Rv3097c|M.tuberculosis_H37Rv LLSWPQINQQLGIAA----------------------
MMAR_1547|M.marinum_M PRYLAQINQELGIAA----------------------
Mflv_4426|M.gilvum_PYR-GCK HEDRAGVYSDLLGAASPVS------------------
Mvan_1822|M.vanbaalenii_PYR-1 HEDRPGVYRDLLGSAGSRAVGLAR-------------