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MTERRIRPSIGRASAWAGAWTVAVGAGAVIACSATAPAWASEDDTSAEPRTAAAAPSKPSQDRPSRASAE RRADTDTGADPSETRVSLRPSRTRATDGDGGDPDTTTVELAVADEPSDPGDVEEPAPESPVAAPALWSLV GSARPQDSGDTATAAVPGTATEAPPTADTTDTDTVPAAADAPVVDQPVYTGRPSFVQQVVIAGLNVLKVV LKPFGGLLAFTSLKIPFFTDGVPPFFLTPGLDVERTEFDGMKVWSLAPRRDQTDKVVVALHGGAYVATAS IFHWWTYADMARDTGATVVVPLQTLVPRGGTAATEVPRTADFLTEMIDAHGAHNVSVFGDSAGGGLALAA VQELNRRSAATPSRLVLLAPWLDVSMSDPRSAEIRDPLLDIPNLVRSGAKWAGSAGVTDPLASPLFGSLE GLPPTYVYSSSRDLLSVDTLRLRERVGAEGIPNVEFRLRAGLIHDWFTFPFLPDAHEDRAGVYSDLLGAA SPVS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4426 | - | - | 100% (494) | alpha/beta hydrolase domain-containing protein |
| M. gilvum PYR-GCK | Mflv_4715 | - | 8e-52 | 34.91% (444) | alpha/beta hydrolase domain-containing protein |
| M. gilvum PYR-GCK | Mflv_4606 | - | 3e-12 | 27.27% (242) | alpha/beta hydrolase domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3124c | PE_PGRS63 | 3e-49 | 41.01% (317) | PE-PGRS family protein |
| M. tuberculosis H37Rv | Rv3097c | lipY | 3e-49 | 41.01% (317) | triacylglycerol lipase |
| M. leprae Br4923 | MLBr_00314 | - | 4e-09 | 25.66% (226) | putative esterase |
| M. abscessus ATCC 19977 | MAB_2584 | - | 7e-20 | 29.20% (250) | putative esterase |
| M. marinum M | MMAR_1547 | - | 5e-61 | 35.25% (505) | PE-PGRS family protein |
| M. avium 104 | MAV_1200 | - | 1e-13 | 28.70% (230) | alpha/beta hydrolase domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_3010 | - | 2e-19 | 30.38% (237) | acetyl-hydrolase |
| M. thermoresistible (build 8) | TH_1370 | lipF | 3e-11 | 27.43% (226) | PROBABLE ESTERASE/LIPASE LIPF |
| M. ulcerans Agy99 | MUL_2832 | lipU_1 | 7e-13 | 26.96% (230) | lipase LipU_1 |
| M. vanbaalenii PYR-1 | Mvan_1822 | - | 1e-162 | 58.63% (527) | alpha/beta hydrolase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
MLBr_00314|M.leprae_Br4923 --------------------------------------------------
MAV_1200|M.avium_104 --------------------------------------------------
TH_1370|M.thermoresistible__bu --------------------------------------------------
MUL_2832|M.ulcerans_Agy99 --------------------------------------------------
Mflv_4426|M.gilvum_PYR-GCK MTERRIRPSIGRASAWAG------AWTVAVGAGAVIACSATAPAWASEDD
Mvan_1822|M.vanbaalenii_PYR-1 MADRNK-----LVVARVG------GLAIAAGAGAVIACSAPAPAFASAED
Mb3124c|M.bovis_AF2122/97 --------MVSYVVALP------------------EVMSAAATDVASIGS
Rv3097c|M.tuberculosis_H37Rv --------MVSYVVALP------------------EVMSAAATDVASIGS
MMAR_1547|M.marinum_M MSFWMWPPEVNSVLLLDGPGPGPMLEAAAAWDGIGTELSAAASAFGSVTS
MSMEG_3010|M.smegmatis_MC2_155 --------------------------------------------------
MAB_2584|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00314|M.leprae_Br4923 --------------------------------------------------
MAV_1200|M.avium_104 --------------------------------------------------
TH_1370|M.thermoresistible__bu --------------------------------------------------
MUL_2832|M.ulcerans_Agy99 --------------------------------------------------
Mflv_4426|M.gilvum_PYR-GCK TSAEPRTAAAAPSKP-SQDRPSR-------ASAERRADTDTGADPSETRV
Mvan_1822|M.vanbaalenii_PYR-1 VGSSANVSTSEPSRPQSTKAPSRQDNADESAASGTSDDNDLGDDRSDESA
Mb3124c|M.bovis_AF2122/97 VVA-------------------------TASQGVAGATTTVLAAAEDEVS
Rv3097c|M.tuberculosis_H37Rv VVA-------------------------TASQGVAGATTTVLAAAEDEVS
MMAR_1547|M.marinum_M ELAGQAWQGPASASMRAAAVRYLDWLGGTAAQAEQSATQARAAAVAYEAA
MSMEG_3010|M.smegmatis_MC2_155 --------------------------------------------------
MAB_2584|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00314|M.leprae_Br4923 --------------------------------------------------
MAV_1200|M.avium_104 --------------------------------------------------
TH_1370|M.thermoresistible__bu --------------------------------------------------
MUL_2832|M.ulcerans_Agy99 --------------------------------------------------
Mflv_4426|M.gilvum_PYR-GCK SLRPS-------------RTRATDGDGGDPDTTTVELAVAD---EPSDPG
Mvan_1822|M.vanbaalenii_PYR-1 ASGTSDDN----DLGDDRSDEAEEPRHSDETVTDEEEAVADQEVATPDLG
Mb3124c|M.bovis_AF2122/97 AA---------------IAALFS-AHGQDYQALSAQLAVFHERFVQALTG
Rv3097c|M.tuberculosis_H37Rv AA---------------IAALFS-GHGQDYQALSAQLAVFHERFVQALTG
MMAR_1547|M.marinum_M LATIVDPGLIVANRGQLVSLAFSNLFGQNAPAIAAAEAAYEQMWAQDVAA
MSMEG_3010|M.smegmatis_MC2_155 --------------------------------------------------
MAB_2584|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00314|M.leprae_Br4923 --------------------------------------------------
MAV_1200|M.avium_104 ------------------------MTAPSEVSGSQSPVRVHDVLKARRAR
TH_1370|M.thermoresistible__bu ------------------------MTAPSKVPRTSPLATR----AARGHY
MUL_2832|M.ulcerans_Agy99 ------------------------MSGVTTFDKLFGPPYDAIRPRRNRRV
Mflv_4426|M.gilvum_PYR-GCK DVEEPA----------------------PESPVAAPALWSLVGSARPQDS
Mvan_1822|M.vanbaalenii_PYR-1 PVDKPAGVPSVHTIDDGFAPAGGDHATPPAGPNLSPAAWTLLGSARRDTE
Mb3124c|M.bovis_AF2122/97 AAKGYAAAELANASL---------LQSEFASGIGNGFATIHQEIQRAPTA
Rv3097c|M.tuberculosis_H37Rv AAKGYAAAELANASL---------LQSEFASGIGNGFATIHQEIQRAPTA
MMAR_1547|M.marinum_M MGGYYSSASATVAALGPWARALENLPGEFARALDNGLVLVEQEIEQAATT
MSMEG_3010|M.smegmatis_MC2_155 --------------------------------------------------
MAB_2584|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_00314|M.leprae_Br4923 -----------------------------MAISAGAPVEIVESGPSIAAR
MAV_1200|M.avium_104 IRK--------------------------FAISDGAPVEVLESGPSVAAR
TH_1370|M.thermoresistible__bu SRT--------------------------FPVSDGTPSEYVEDGPSLAGR
MUL_2832|M.ulcerans_Agy99 GRR--------------------------AASGHGAHVEVVESGPSIAAR
Mflv_4426|M.gilvum_PYR-GCK ---GDTATAAVPG----------------TATEAPPTADTTDTDTVPAAA
Mvan_1822|M.vanbaalenii_PYR-1 ---AAAVPPSQPD----------------TTSETVNTDAAAATDPATAVA
Mb3124c|M.bovis_AF2122/97 ---LAAG------FTQV--------------PPFAAAQAGIFTGTPSGAA
Rv3097c|M.tuberculosis_H37Rv ---LAAG------FTQV--------------PPFAAAQAGIFTGTPSGAA
MMAR_1547|M.marinum_M ---LATE------FTQVSNTLFTTIFGAPADPPFAASQTGTFTGTPSLIT
MSMEG_3010|M.smegmatis_MC2_155 ------------------------------MIQACVILRHHGNGLVTAHT
MAB_2584|M.abscessus_ATCC_1997 ------------------------------------------MVSVRARA
MLBr_00314|M.leprae_Br4923 LASLTSRLTIRPI-LAVGSYVPQLPWP-FGLIDHAARVLLPVTNAARAEV
MAV_1200|M.avium_104 LANLTSRLTIRPI-LAVGSHAPNLPWP-WGLIDLTARVLLPVSATVRETV
TH_1370|M.thermoresistible__bu LTALAAYLTVRPT-LAIGSFAPRLPWP-WGLLDFAARAVRPVPGTVRATI
MUL_2832|M.ulcerans_Agy99 VVSLASRLTVRPV-IAVASHFPHLPWP-WSLVDFALLPITWASGIIGERV
Mflv_4426|M.gilvum_PYR-GCK ---DAPVVDQPVY-TGRPSFVQQVVIAGLNVLKVVLKPFGGLLAFTSLKI
Mvan_1822|M.vanbaalenii_PYR-1 SLKDPLGEDESRY-TGKPSFVHDVVTFGLYVLKAVLKPFGGLLAFTGLKV
Mb3124c|M.bovis_AF2122/97 GFDIASLWPVKPL-LSLSALETHFAIPNNPLLALIASDIPPLSWFLGNSP
Rv3097c|M.tuberculosis_H37Rv GFDIASLWPVKPL-LSLSALETHFAIPNNPLLALIASDIPPLSWFLGNSP
MMAR_1547|M.marinum_M RFENTALLPLKPL-LSVSGLDSQIAVPGNPLLALVASDIPPLSWFIGNSP
MSMEG_3010|M.smegmatis_MC2_155 LAPMSINQPNDPLGVIYAEWTEEFVANPDMSLRLMRWVFEDWQRVTSEPE
MAB_2584|M.abscessus_ATCC_1997 FIAAARLQRKKSFYATAAGMRRRLSAHQSAARCEPPRSVRRHRRITR---
. . .
MLBr_00314|M.leprae_Br4923 N----------------LSNTSAQLVRAAGVRP-ADGSGRIVLYLHGGAF
MAV_1200|M.avium_104 A----------------LPHASAQLVRAPGVLP-ADGTRRVVVYLHGGAF
TH_1370|M.thermoresistible__bu R----------------LPHCTAQLVRAPGVLP-ADGRRSVVLYLHGGAF
MUL_2832|M.ulcerans_Agy99 S----------------LPNASGHLVRASGVPP-PDGSRRVVLYMHGGAF
Mflv_4426|M.gilvum_PYR-GCK PFFTDGVPPFFLTPGLDVERTEFDGMKVWSLAPRRDQTDKVVVALHGGAY
Mvan_1822|M.vanbaalenii_PYR-1 PFFTDGIPPFFLTPGLDVERSEFEGMKVWTLTPRKNATEKTVVALHGGAY
Mb3124c|M.bovis_AF2122/97 PPLLN------SLLGQTVQYTTYDGMSVVQITP-AHPTGEYVVAIHGGAF
Rv3097c|M.tuberculosis_H37Rv PPLLN------SLLGQTVQYTTYDGMSVVQITP-AHPTGEYVVAIHGGAF
MMAR_1547|M.marinum_M PPLLN------LLLGETVQYSTYDGMSVVQITP-AHPTGDYVVAIHGGAF
MSMEG_3010|M.smegmatis_MC2_155 D--------------VTYASTRIGGVPGILVKPLDADPGQMLVVLHGGGF
MAB_2584|M.abscessus_ATCC_1997 --------------------HEVQGHSCYTLHPDGRWDGLHVFHLHGGGF
: * :. :***.:
MLBr_00314|M.leprae_Br4923 LGCGANSHRRLVETLSKLADSPILVVNYRLLPKHSIGMALDDCHDGYQWL
MAV_1200|M.avium_104 LTCGANSHGRLVEALSTFADAPVLVVNYRLLPKNSVGMALQDCHDAYQWL
TH_1370|M.thermoresistible__bu LTCGAHTHGRLVTALSEFADSPVLVVNYRMIPKHSVGTAIDDCYDGYQWL
MUL_2832|M.ulcerans_Agy99 LKGGIHSHARLAGTLSKFADSPLLVVNYRLVPKHTVGMALEDCHDAYLWL
Mflv_4426|M.gilvum_PYR-GCK VATASIFHWWTYADMARDTGATVVVPLQTLVPRGGTAATEVPRTADFLTE
Mvan_1822|M.vanbaalenii_PYR-1 VATASIFHWWTYADMARDTGATVIVPLQTLVPAGGTAASEVPRTANFISK
Mb3124c|M.bovis_AF2122/97 ILPPSIFHWLNYSVTAYQTGATVQVPIYPLVQEGGTAGTVVPAMAGLIST
Rv3097c|M.tuberculosis_H37Rv ILPPSIFHWLNYSVTAYQTGATVQVPIYPLVQEGGTAGTVVPAMAGLIST
MMAR_1547|M.marinum_M IFPPSFLHWINYSVMAHQTGATVQVPIYPLLQEGGTAGTVVPAMAGLISN
MSMEG_3010|M.smegmatis_MC2_155 ALGSSASHRKLAGHLARAFGAHAFVADFRLAPEHPYPAQIDDATAVFTSL
MAB_2584|M.abscessus_ATCC_1997 VEQPEKHHWRFADNLVGALGCRYSMFMYPLAPEHDHREITAVSRRAYREM
* .. : :
MLBr_00314|M.leprae_Br4923 RRLGYDPEQIVLAGDSAGGYLALALAQRLQDVGEE-PAALVAISPLLQLA
MAV_1200|M.avium_104 RLRGYQPDQIVLAGDSAGGYLALTLAQRLQRDGEE-PAALVMISPLLQLA
TH_1370|M.thermoresistible__bu RAKGYEPDQIVLAGDSAGGYLALSLAQRLLDEGEE-PAALVALSPLFEID
MUL_2832|M.ulcerans_Agy99 RLRGHAPEQIVLAGDSAGGYLAFALAQRLRARGEE-PAALVAISPLLQLA
Mflv_4426|M.gilvum_PYR-GCK MIDAHGAHNVSVFGDSAGGGLALAAVQELNRRSAATPSRLVLLAPWLDVS
Mvan_1822|M.vanbaalenii_PYR-1 VIEDHGADNVSVIGDSAGGGLALAAIQELARRNSRNPSRLVLISPWLDVS
Mb3124c|M.bovis_AF2122/97 QIAQHGVSNVSVVGDSAGGNLALAAAQYMVSQGNPVPSSMVLLSPWLDVG
Rv3097c|M.tuberculosis_H37Rv QIAQHGVSNVSVVGDSAGGNLALAAAQYMVSQGNPVPSSMVLLSPWLDVG
MMAR_1547|M.marinum_M QIMQHGAANVSVIGDSAGGNLALGAVEYMASQGSQVPSSMVLLSPWLDLG
MSMEG_3010|M.smegmatis_MC2_155 LDNGIDASSITFVGDSAGASIAVATTLRLLRDGAPVPGRVITISPWLDME
MAB_2584|M.abscessus_ATCC_1997 MADTPQ-SGRVLFGDSAGGSLSLGITQELRDRGEAQPACIALFSPWLNMA
. *****. ::. : . *. : ::* :::
MLBr_00314|M.leprae_Br4923 KKGKQAHPNAKTDAMFPPKAFDALGRLVASSAAKNKVDDKPEELYEPLDH
MAV_1200|M.avium_104 KEPKQAHPNIDTDAMFGAGAFDALAELVAGAAAKNIVDGKPEEIYEPLEH
TH_1370|M.thermoresistible__bu NESRAQHPNIRTDAMFPPRAFSALIELVEEAAERRTTNGRPEEVYEPLDN
MUL_2832|M.ulcerans_Agy99 MRSKKAHPNIKSDAMFPARAFDALVAIVAGAAARNETAGRREEIYEPLEH
Mflv_4426|M.gilvum_PYR-GCK MS--------DPRSAEIRDPLLDIPNLVRSGAKWAGSAGVTDPLASPLFG
Mvan_1822|M.vanbaalenii_PYR-1 MS--------DPRSAEIRDPLLDLANPTKSGAKWAGEAGTADPQASPLFG
Mb3124c|M.bovis_AF2122/97 T--------------------------WQISQAWAGNLAVNDPLVSPLYG
Rv3097c|M.tuberculosis_H37Rv T--------------------------WQISQAWAGNLAVNDPLVSPLYG
MMAR_1547|M.marinum_M MT--------NPNIAFVQDPLLPFGPAQQIGKAWAGNLAVTDPMVSPLYG
MSMEG_3010|M.smegmatis_MC2_155 NSGSTIESNDATDFLITREGLQG-----NIDRYLSGGASPTDPLVNPLYA
MAB_2584|M.abscessus_ATCC_1997 VD------HELSQVIEPHDPELGLAGLQQAGRWYAADRPLDDPELSPEHA
: .*
MLBr_00314|M.leprae_Br4923 IAPGLPRTLIHVSGSEVLLHDAQLAATKLAAVGVP-AEIRVWPGQVHVFQ
MAV_1200|M.avium_104 IEPGLPRTLIHVSGSEVLLHDARLAASRLAAAGVP-AEVRVWPGQIHDFQ
TH_1370|M.thermoresistible__bu IEPGLPRTLIHVSGSEALISDARKAARRLAAAGVP-VEIRVWPGQMHVFQ
MUL_2832|M.ulcerans_Agy99 IAPGLPPTLIHVSGAEALLHDARLAAGKLAAAGVR-AEVRVWPGQLHDFQ
Mflv_4426|M.gilvum_PYR-GCK SLEGLPPTYVYSSSRDLLSVDTLRLRERVGAEGIPNVEFRLRAGLIHDWF
Mvan_1822|M.vanbaalenii_PYR-1 SLKGLPPTYVYSSSLDLLTVDTLRLRDRVLAEQVPDVEFRLRKNLIHDWF
Mb3124c|M.bovis_AF2122/97 SLNGLPPTYVYSGSLDPLAQQAVVLEHTAVVQGAP-FSFVLAPWQIHDWI
Rv3097c|M.tuberculosis_H37Rv SLNGLPPTYVYSGSLDPLAQQAVVLEHTAVVQGAP-FSFVLAPWQIHDWI
MMAR_1547|M.marinum_M SLSGLPPTYVYAGSQEILAPDVLVLQQEAAAIGAP-FNFVLAHGQIHDWV
MSMEG_3010|M.smegmatis_MC2_155 DFTGFPRLYITVSDTESLYADATRLAEKARAAGVD-VTFEVASGQQHVFP
MAB_2584|M.abscessus_ATCC_1997 NLAGIAALSIFIGTRDILLPDALLLHFNACTVGTT-SRLQIYDGMFHNWA
*:. : . : * :. . . : * :
MLBr_00314|M.leprae_Br4923 AAAPMVPEATLSLRQISQYIREATASKASRDRQSL---------------
MAV_1200|M.avium_104 LAAPMVPEARRSLRQIGDYIREATG-------------------------
TH_1370|M.thermoresistible__bu IAAPFVPEAKRSLRQIGEYIREATW-------------------------
MUL_2832|M.ulcerans_Agy99 VAAPMLPEATYSLRQIGEYIRQATG-------------------------
Mflv_4426|M.gilvum_PYR-GCK TFPFLP-DAHEDRAGVYSDLLGAASPVS----------------------
Mvan_1822|M.vanbaalenii_PYR-1 TFPFLP-EAHEDRPGVYRDLLGSAGSRAVGLAR-----------------
Mb3124c|M.bovis_AF2122/97 LLTPW---GLLSWPQINQQLGIAA--------------------------
Rv3097c|M.tuberculosis_H37Rv LLTPW---GLLSWPQINQQLGIAA--------------------------
MMAR_1547|M.marinum_M LLTLD---GPRYLAQINQELGIAA--------------------------
MSMEG_3010|M.smegmatis_MC2_155 LQAGVLPEADAAIESMAAWYRSAKPLAV----------------------
MAB_2584|M.abscessus_ATCC_1997 MKPIP--EAHRARRQLIEFLAESTRAAALSEKEQTHHDRSDNRRDHRNRP
. . : :
MLBr_00314|M.leprae_Br4923 ----------------
MAV_1200|M.avium_104 ----------------
TH_1370|M.thermoresistible__bu ----------------
MUL_2832|M.ulcerans_Agy99 ----------------
Mflv_4426|M.gilvum_PYR-GCK ----------------
Mvan_1822|M.vanbaalenii_PYR-1 ----------------
Mb3124c|M.bovis_AF2122/97 ----------------
Rv3097c|M.tuberculosis_H37Rv ----------------
MMAR_1547|M.marinum_M ----------------
MSMEG_3010|M.smegmatis_MC2_155 ----------------
MAB_2584|M.abscessus_ATCC_1997 TARHRELDVEADRSRG