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DFSLLPPEVNSARMYTGPGSGSLLAAAASWDALAAELGTTAETCGSILTGLTDLSWRGPASESMAASAAP YVGWLYRTAEQTQQAAIQARTAALAFEQAYAMTVPPPLVAANRAQLLVLIATNFFGQNTSAIAANEAQYA EMWAQDAAAMYGYATTSAAAGMLTPFSSPNQATSPAGLAAQSTAVTQANATAAATDPITQLVSSLTQSLG AIQAIPSILPDDFTILDGVFSAYATVGVTQDIESFCAGVIGAENNLGLIGSSENPAEVTPSDFGLGSLIS STAPASAASGGGLGSAVAASVGRSGSIGQLSVPPSWSAPSARMVSALSPSGLTTIPGTEEAAAAGSPGFP GMVAPPATRASGVLPRYGVRLTVMAHPPAAG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_1513 | - | - | 100% (382) | PPE family protein, PPE51 |
| M. marinum M | MMAR_0191 | - | e-145 | 68.23% (384) | PPE family protein, PPE51_2 |
| M. marinum M | MMAR_1514 | - | e-128 | 62.08% (385) | PPE family protein, PPE51_1 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3160 | PPE51 | 1e-152 | 70.95% (389) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0325 | - | 2e-33 | 31.44% (388) | PPE protein |
| M. tuberculosis H37Rv | Rv3136 | PPE51 | 1e-152 | 70.95% (389) | PPE family protein |
| M. leprae Br4923 | MLBr_01182 | - | 5e-45 | 32.86% (420) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_0047 | - | 7e-32 | 37.73% (220) | PPE family protein |
| M. avium 104 | MAV_4014 | - | 1e-100 | 50.38% (393) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0619 | - | 5e-37 | 33.07% (381) | PPE family protein |
| M. thermoresistible (build 8) | TH_3113 | - | 7e-34 | 31.54% (409) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_2428 | - | 0.0 | 99.74% (382) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0415 | - | 1e-32 | 37.96% (216) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE
Mvan_0415|M.vanbaalenii_PYR-1 ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE
MSMEG_0619|M.smegmatis_MC2_155 ----------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAE
MAB_0047|M.abscessus_ATCC_1997 ----------MSAPIWMASPPEVHSALLSAGPGPGALLAAAAQWQALSTQ
TH_3113|M.thermoresistible__bu ----------------MALPPEVHSTLLRTGPGPGALSAAADAWRMLSDE
MMAR_1513|M.marinum_M -------------MDFSLLPPEVNSARMYTGPGSGSLLAAAASWDALAAE
MUL_2428|M.ulcerans_Agy99 -------------MDFSLLPPEVNSARMYTGPGSGSLLAAAASWDALAAE
Mb3160|M.bovis_AF2122/97 -------------MDFALLPPEVNSARMYTGPGAGSLLAAAGGWDSLAAE
Rv3136|M.tuberculosis_H37Rv -------------MDFALLPPEVNSARMYTGPGAGSLLAAAGGWDSLAAE
MAV_4014|M.avium_104 -------------MDWAFLPPEINSARMYTGAGAASLLAAAGSWDALSAE
MLBr_01182|M.leprae_Br4923 ------------MFDFAALSPETNSTRMYLGPGSSPILTAAAAWVVLAKE
.** :*: : *.*...: :*. * *: :
Mflv_0325|M.gilvum_PYR-GCK YASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA
Mvan_0415|M.vanbaalenii_PYR-1 YAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA
MSMEG_0619|M.smegmatis_MC2_155 YAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAA
MAB_0047|M.abscessus_ATCC_1997 YATAATELTELLGSTVAGSWQGPSAMQYAASHAPYLAWLTQQSAMSATNA
TH_3113|M.thermoresistible__bu YRAAAVELAAVVSQTCATAWEGVGADAYAAAHGPYLFWLTDTAAAAAAAG
MMAR_1513|M.marinum_M LGTTAETCGSILTGLTDLSWRGPASESMAASAAPYVGWLYRTAEQTQQAA
MUL_2428|M.ulcerans_Agy99 LGTTAETCGSILTGLTDLSWRGPASESMAASAAPCVGWLYRTAEQTQQAA
Mb3160|M.bovis_AF2122/97 LATTAEAYGSVLSGLAALHWRGPAAESMAVTAAPYIGWLYTTAEKTQQTA
Rv3136|M.tuberculosis_H37Rv LATTAEAYGSVLSGLAALHWRGPAAESMAVTAAPYIGWLYTTAEKTQQTA
MAV_4014|M.avium_104 LTATADGYESVLSGLG-LQWHGPAADAMAFAAARYLTWLRATAEQTKQTA
MLBr_01182|M.leprae_Br4923 LTAAAQGLQSAVEALL-TTFEGESAAALAERVTPYEKWLTQNAASAELTA
::* : :.* .: . ** : .
Mflv_0325|M.gilvum_PYR-GCK VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE
Mvan_0415|M.vanbaalenii_PYR-1 AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE
MSMEG_0619|M.smegmatis_MC2_155 VQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNE
MAB_0047|M.abscessus_ATCC_1997 VLHETSAAAYTTALAAMPTLAELAANHMIHGVLLATNFFGINTIPIALNE
TH_3113|M.thermoresistible__bu AQLEAAAAAHASALAAMPTMAELTANRTTHAALVATNFFGVNTIPIAVNE
MMAR_1513|M.marinum_M IQARTAALAFEQAYAMTVPPPLVAANRAQLLVLIATNFFGQNTSAIAANE
MUL_2428|M.ulcerans_Agy99 IQARTAALAFEQAYAMTVPPPLVAANRAQLLVLIATNFFGQNTSAIAANE
Mb3160|M.bovis_AF2122/97 IQARAAALAFEQAYAMTLPPPVVAANRIQLLALIATNFFGQNTAAIAATE
Rv3136|M.tuberculosis_H37Rv IQARAAALAFEQAYAMTLPPPVVAANRIQLLALIATNFFGQNTAAIAATE
MAV_4014|M.avium_104 MQARTAAAAYEQAYAMTVPPPVIAANRTLLASLVATNIMGQNTAAIADTE
MLBr_01182|M.leprae_Br4923 TQLTVAANAYETAFTMTVPPLMVFVNRAQACLLIMSNIFGQNSTAIAEKE
.:* *. * : . : *: *: :*::* *: .** .*
Mflv_0325|M.gilvum_PYR-GCK ADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLPGVGEAGR---
Mvan_0415|M.vanbaalenii_PYR-1 ADYVRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAPGVGEAGR---
MSMEG_0619|M.smegmatis_MC2_155 ADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKPGVGEAGS---
MAB_0047|M.abscessus_ATCC_1997 ADYIRMWIQAATTMGVYQGVSSAALAATTPTQPSPMIMAPG-GEMSR---
TH_3113|M.thermoresistible__bu ADYARMWIQAATTMATYEAVASAAVSATPRTVAPPPILGAGTGESAT---
MMAR_1513|M.marinum_M AQYAEMWAQDAAAMYGYATTSAAAG-MLTPFSSPNQATSPA---------
MUL_2428|M.ulcerans_Agy99 AQYAEMWAQDAAAMYGYATTSAAAG-MLTPFSSPNQATSPA---------
Mb3160|M.bovis_AF2122/97 AQYAEMWAQDAAAMYGYATASAAAA-LLTPFSPPRQTTNPA---------
Rv3136|M.tuberculosis_H37Rv AQYAEMWAQDAAAMYGYATASAAAA-LLTPFSPPRQTTNPA---------
MAV_4014|M.avium_104 AQYADFWAQDTAAMAGYSASSTAAT-QLPRFASANNSTNES---------
MLBr_01182|M.leprae_Br4923 AEYTEMWIQDAAAMTSYQASVLEAVGATKAFTAPPLGVNEVGLAQEVVEE
*:* :* * :::* * * ..
Mflv_0325|M.gilvum_PYR-GCK -----AAADMSAFAAQPMAAQAGAAFDVSNIIADIIRLYGEVLRFLFEPI
Mvan_0415|M.vanbaalenii_PYR-1 -----AAADVTAFAAQAQAAEAGSALDLSNIIADLIRAYGELLRFLFEPI
MSMEG_0619|M.smegmatis_MC2_155 -----ASASVQQMSAQATAAESGSSLDLSSIISDLLNQYLQGVPGG-QAI
MAB_0047|M.abscessus_ATCC_1997 -----MSADMMSMAAQPQAAESGSALDSSNNIMDQL--------------
TH_3113|M.thermoresistible__bu -----AAITGAHVTAELRAAESRTLLDEINELIDRLFAPLFPPG----FA
MMAR_1513|M.marinum_M -------GLAAQSTAVTQANATAAATDPITQLVSSLTQSLGAIQA-----
MUL_2428|M.ulcerans_Agy99 -------GLAAQSTAVTQANATAAATDPITQLVSSLTQSLGAIQA-----
Mb3160|M.bovis_AF2122/97 -------GLTAQAAAVSQA------TDPLSLLIETVTQALQALT------
Rv3136|M.tuberculosis_H37Rv -------GLTAQAAAVSQA------TDPLSLLIETVTQALQALT------
MAV_4014|M.avium_104 -------GVTAQNAAVSAANANAAANKAVTQSFSPLADNPPGTTINNYYV
MLBr_01182|M.leprae_Br4923 VVEEVVEEVVEAEQAISQAALDQAVNEGMEATVVPQVDQQVNVDVATP--
* * .
Mflv_0325|M.gilvum_PYR-GCK FNFLRDPIGNTFALITDFLTNPVQALITWGPFLLAVVYQA----VSWVGA
Mvan_0415|M.vanbaalenii_PYR-1 FDFLRDPLGNTIKLITDFLTNPAQALITWGPFLAAVAYQA----VSWVGA
MSMEG_0619|M.smegmatis_MC2_155 LDFLKDPLGNLGRLLTDFMTNPAGALATWWPFLFGVAYQVFFNLVGWPTW
MAB_0047|M.abscessus_ATCC_1997 MRFMTNPLGTLQDMIEDFMRNPVAAFFAWFPLLFFIAYEAFFIPFGFTFW
TH_3113|M.thermoresistible__bu DALPDGLLGTLLAPLLPGATGDGPPMATIMSFLLMGLSNP---AYLFPVL
MMAR_1513|M.marinum_M ----IPSILPDDFTILDGVFSAYATVGVTQDIESFCAGVIG---------
MUL_2428|M.ulcerans_Agy99 ----IPSILPDDFTILDGVFSAYATVGVTQDIESFCAGVIG---------
Mb3160|M.bovis_AF2122/97 ----IPSFIPEDFTFLDAIFAGYATVGVTQDVESFVAGTIG---------
Rv3136|M.tuberculosis_H37Rv ----IPSFIPEDFTFLDAIFAGYATVGVTQDVESFVAGTIG---------
MAV_4014|M.avium_104 DASSTSAANSNAFRVLDVIQGTGLGFSAPYNMEQFVSGIIG---------
MLBr_01182|M.leprae_Br4923 ---QTAVPDSSSAAAPQLWGGFAQHLSPINDTLSMINNHAG---------
.
Mflv_0325|M.gilvum_PYR-GCK SILYPSLFLLPLLATT--LAIVAGVGQHLLSLLNTPPAEEAAEEPAPAQS
Mvan_0415|M.vanbaalenii_PYR-1 SILYPSLLLLPLVATT--LAIVLGVGAYLLENLPAPAEDAPAEEPAASSP
MSMEG_0619|M.smegmatis_MC2_155 GMIFASPFLIPALAALGITGLVLLIDHVLNNPVDVPAEDEAPQEVAAAP-
MAB_0047|M.abscessus_ATCC_1997 GVLLSAPAWLPIVLGLALSALVPPAG-----IEEPGQEDEPGREPTRIE-
TH_3113|M.thermoresistible__bu VYLLFTGVVHTTVAVSGMLAQLVPLMPALLPVAVAALGGLAGVWAGLSGL
MMAR_1513|M.marinum_M --------------------------------------------------
MUL_2428|M.ulcerans_Agy99 --------------------------------------------------
Mb3160|M.bovis_AF2122/97 --------------------------------------------------
Rv3136|M.tuberculosis_H37Rv --------------------------------------------------
MAV_4014|M.avium_104 --------------------------------------------------
MLBr_01182|M.leprae_Br4923 --------------------------------------------------
Mflv_0325|M.gilvum_PYR-GCK APSRPDQQSFPATMSAPPPPSGAPIAANTVSAG-SPPAPGAPAAAAATFV
Mvan_0415|M.vanbaalenii_PYR-1 APTRADQPSPAIAVSAPPPPSSAAATVGTVATG-TAPAPGAPAAATASFV
MSMEG_0619|M.smegmatis_MC2_155 ---RTDQP-LAVGISPAGVPGSAATAAAPAPAP-AGTTVAAPAPAAATFV
MAB_0047|M.abscessus_ATCC_1997 --RRSPQQDLQLAHVPSGSPTPGGSTTTTVTSGGSAPPAPAPATATPAYM
TH_3113|M.thermoresistible__bu AGLAGLTAVPAADGGASAAPVPAG--GPSLPSGSSAPPAPTGSAAPTTGT
MMAR_1513|M.marinum_M -----------AENN-LGLIGS-SENPAEVTPSDFGLGSLISSTAPAS--
MUL_2428|M.ulcerans_Agy99 -----------AENN-LGLIGS-SENPAEVTPSDFGLGSLISSTAPAS--
Mb3160|M.bovis_AF2122/97 -----------AESN-LGLLNVGDENPAEVTPGDFGIGELVSATSPGGGV
Rv3136|M.tuberculosis_H37Rv -----------AESN-LGLLNVGDENPAEVTPGDFGIGELVSATSPGGGV
MAV_4014|M.avium_104 -----------AENN-LGMLAKPGAAAANIAP-ALAAPALRGATAGLG--
MLBr_01182|M.leprae_Br4923 -----------MANAGLSLVNGMGSAMKSLAPTTTKAAESAFKAMGSAVQ
.. .
Mflv_0325|M.gilvum_PYR-GCK PYVVAGRDPYEGFSPTVRDSTGAKAPAGTIPAAASGIAASAAERRKRRRR
Mvan_0415|M.vanbaalenii_PYR-1 PYAVAGRDPGTGFSPTVRDSTSAKAPASGIPAAASGVAASAAERRKRRRR
MSMEG_0619|M.smegmatis_MC2_155 PYAVANRDPGEGFTPTLGNKSQVAAPASGVPAAASGVAASLASRRKRRRK
MAB_0047|M.abscessus_ATCC_1997 VYAVQEDPPAARFGPTLNEGSGAKAPAAGISAAA---AAAASARSRARRK
TH_3113|M.thermoresistible__bu APGGAGSPPPAGHSVPPAPHSAPPVGTSGPPYLIAAQPAPGVARRSAGAR
MMAR_1513|M.marinum_M AASGGG----LGSAVAASVGRSGSIGQLSVPPSWS---APSARMVSALSP
MUL_2428|M.ulcerans_Agy99 AASGGG----LGSAVAASVGRSGSIGQLSVPPSWS---APSARMVSALSP
Mb3160|M.bovis_AF2122/97 SASGAGGAASVGNTVLASVGRANSIGQLSVPPSWA---APSTRPVSALSP
Rv3136|M.tuberculosis_H37Rv SASGAGGAASVGNTVLASVGRANSIGQLSVPPSWA---APSTRPVSALSP
MAV_4014|M.avium_104 GGLGGG-----LGNVTATLSHAGTIGPMSVPATWS---APTSTHVSPLAP
MLBr_01182|M.leprae_Br4923 STGRGLLGSSSGGHVTAQLGRAASIGSLRVPQTWTTASQPVTAATRALSP
. .
Mflv_0325|M.gilvum_PYR-GCK QKEEIKGRG--YADAYADYEELPDDGP-PEQPAPRVTASTRGAGPMGFAG
Mvan_0415|M.vanbaalenii_PYR-1 QKDEIAGRA--YADAYADYEPEPDDEP-PVRQEPRIAATERGAGPMGFAG
MSMEG_0619|M.smegmatis_MC2_155 KGAQIEERG--YADAYMDYEE-PDEDP-APQPEPRVRASERGSDAMGFTG
MAB_0047|M.abscessus_ATCC_1997 RAARIKDPA--PQFMDMNSSVAPDFSESAARQTTGVGASARGAGRLGFAG
TH_3113|M.thermoresistible__bu RAASIVEPAGSAAAAAAARESAPIRRRRGQKDGLHGHRHEHQQPASMSAA
MMAR_1513|M.marinum_M S--GLTTIPGTEEAAAAGSPGFPGMVAPPATRAS--GVLPRYGVRLTVMA
MUL_2428|M.ulcerans_Agy99 S--GLTTIPGTEEAAAAGSPGFPGMVAPPATRAS--GVLPRYGVRLTVMA
Mb3160|M.bovis_AF2122/97 A--GLTTLPG-TDVAEHGMPGVPG-VPVAAGRAS--GVLPRYGVRLTVMA
Rv3136|M.tuberculosis_H37Rv A--GLTTLPG-TDVAEHGMPGVPG-VPVAAGRAS--GVLPRYGVRLTVMA
MAV_4014|M.avium_104 A--GFTTLPGTEEPMASGYPGYPGMPGGGAARSAGVGVPPRYGVRLTVMP
MLBr_01182|M.leprae_Br4923 ARVAVATESESAPLLGGGLPMAPMVPGGGSGTGG-VNTALRLQPRAFVMP
. * :
Mflv_0325|M.gilvum_PYR-GCK TVSRGD--EQAGGLT---TLAGDSFGGGPREPMLPGTWDPDATDDRHTDG
Mvan_0415|M.vanbaalenii_PYR-1 TVSRDA--AQAGGLT---TLPGDPFGGGPKAPMLPGTWDPDTEPD-----
MSMEG_0619|M.smegmatis_MC2_155 TVTRHD--VTAAGLT---TLTGDTFDDRPVTPMLPGTWDGDENPAP----
MAB_0047|M.abscessus_ATCC_1997 TAPAAAGTTAAAGLVERDSGTAEALDGARTVPMLPTSWGTDSEHGP----
TH_3113|M.thermoresistible__bu TAPSAAGIRVLGGAG----RISRTRGSVPHAEITPGDPTEPSSPTDR---
MMAR_1513|M.marinum_M HPPAAG--------------------------------------------
MUL_2428|M.ulcerans_Agy99 HPPAAG--------------------------------------------
Mb3160|M.bovis_AF2122/97 HPPAAG--------------------------------------------
Rv3136|M.tuberculosis_H37Rv HPPAAG--------------------------------------------
MAV_4014|M.avium_104 RPPAAG--------------------------------------------
MLBr_01182|M.leprae_Br4923 RNPAAG--------------------------------------------
.
Mflv_0325|M.gilvum_PYR-GCK RDGHDGHDGKEKP
Mvan_0415|M.vanbaalenii_PYR-1 -ERHNHHDGKDSQ
MSMEG_0619|M.smegmatis_MC2_155 --SPDDPEGGPRR
MAB_0047|M.abscessus_ATCC_1997 ---DRPAEGGSST
TH_3113|M.thermoresistible__bu --AHRPAEPN---
MMAR_1513|M.marinum_M -------------
MUL_2428|M.ulcerans_Agy99 -------------
Mb3160|M.bovis_AF2122/97 -------------
Rv3136|M.tuberculosis_H37Rv -------------
MAV_4014|M.avium_104 -------------
MLBr_01182|M.leprae_Br4923 -------------