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VLDHSISAVLRERASLRPSETAFTFIDYERDWAGIAETLTWSQLHRRTCNVARELKACGATGDRAVVLAP QGLDYIVAFLGALQAGQIAVPLSAPLGGASDERVGSVLRDALPSAILTTSPIAGDVAECITLTPGKRAPS VIEIDLLDPDSGQGPAAESDSGSDIAYLQYTSGSTRTPAGVVVSHRNLLANVEQGMSAYFGDHGRAAPPD TTVVSWLPFFHDMGLMFGIIMPLLEGFHSVLTSPISFLQRPARWMQLLASNCQVFSAAPNIAFELAARKT SDDDLAGLDLGGVRNILSGAERVQPATLARFAQRFARFHLHPRALRPSYGLAEATVFVATREWGQPPVTV YFDSDELTAGHAKRCATGTGTALISYGAAQSPTVRIVDPQTATECPAGVVGEIWVHGDNVAAGYWHRPQE TERTFGATLVGPSPGTPPGPWLRTGDLGAFSEGELFIIGRIKDLLIIYGRNHSPDDIEATIQEVTRGRCV AIAVPDDGGVEKLVVIVEFKTRETSHEATMHRMGVVRRDVIAAISKTHGLNVADLVLVPPGSIPLTTSGK VRRRECLQRYLHDEFTRLDGQLREPGPRVADAAAADADAGADSGLVQRLRLLRHQQHDLLVGVVCAQAAT VLDYPSPNDIDPEWAFQDLGFDSVKATELLDRLQTVTELTLPPTLAFDYPTPAALATHLGQLLSGSVAVA APVQPRVSTDEPVAVVGMACRFPGGVDSAAALWDLVAGGTEAVGEFPADRGWNLAELFDPDPDAVGKTYA RAGSFVADVAGFDAEFFGISAREAQTMDPQQRLLLEVCWEALETAQIDPAALLRSKTGVFVGAWSQQYGG GSEGAEGYGLTGLSTSVASGRVAYALGLQGPAITIDTACSSSLVAAHLACQSLHTGESTLALAGGVTVMT TPAVFTEFARQRGLAADGRCKAFSAAADGTGWGEGAAVLVLERLSDANRNGHPVLAVIAGSAINQDGASN GLTAPSGPAQQRVITQAVANAGVGLDEVDAVEAHGTGTTLGDPIEAGALIATYGAAHHPDHPLWLGSIKS NIGHTQAAAGVAGLIKMIAALNHDSLPPTLNVDRPSPHVDWSAGTVRVLTEPVPWPVTDHPRTAAVSSFG ISGTNAHLILQQAPTPSSGSPEPAGRPQHGAELGLPMWPVSARTPAGLAAQAERLHQHLLRHRDLDLTDV GYSLGCTRTHHPHRAVVTVPAASPDPRAELLAALQALAAGDPHPQLVQHHLRSTSAGKTVFVFPGQGGQY PGMAAELYRRHQVFSRALDECDQALFGWTGWSVGAVVRGEPSAMALQRVDVVQPVLFAVMVSLARTLISY GIEPDAVIGHSQGEIAAAYVAGVFTLEQAAKIVALRSAALADLSGTGGMASVLLGADEVAARLQPYGDAL TVAAVNGPTHTIISGDPPAIEAFVAAGEADGIQIRSITVDYASHCGQVEPARERLLGELAGLTPAPGRIA LYSTVHGVTSDQPLDTTTMTADYWYANLRQPVRFYDSIKVLLAAAEQVFVEISPHPVLAPAITDTLAASN GQRPGSVVIPTLHRERPDLDALTTTLARLQVHGRGPAWPVVYPHARPVPLPTYPFQHHRYWLTTGPGNDA AGLGLDRVGHPLLGAITALADRDEVIATGRLALGVQGWLGAHRVGDVVVLPGTAFVDMALAVGDYVGCPA VAELVLHAPLVLAEDTPTDIQIGVAGADGGARRAFNVHARTGTGHRGETGWVLHASGILAAEPAAAGQPP MAALPVTEFDVADFYQRLADRGLHYGPPFCSVLGIGHEPADPDHIYAEVALPAGTDITGYGIHPALLDAA LHPMAAALGAGADSESAAVRLPFVLSGVTLHATAATRLQVWLTRSSADTFTLYASDPAGAPVISIDTVVV RALPDLATLTPPTTATSSGRGLWELAWPPLSSAGAPGAAVVAEPPAWVVVAEDPDAVSAGLRNGVRRPDL DAVRPCPPVVIWSLSPPDLRGDDDAVVSSMHSLTRHALAAVAAWLARPDTAETVLVVLTCRAVAINAYER APNPAQAAVWALLHSAQSEHPGRIRLVDTDHAASSTDTLLQLLGSCTGTGGEPQLALRAGVAHMPRLAPA RALTPPPTPHWRLITSGSGDLADLTLAPTPAPAELGPGQIRVQIRAAGLNSDDVAVASAATSHRDAGGEG QQDHQGLGVEAAGIVIDTAGDVDDLAPGDAVMGIFPNNAFAPTAATDHRAVVAIPPGWSCPQAASVPVAF VTAYSALIDIAALRAGQRVLIHSGAGAVGRAAIRIAQHLGAEVFATADPAEQHILRGLGIPEDHIASSRA RDFGDTLAAATGGRGMDVVLNDLRGDLVDASLRLLAAPGCFVEIARRDIREATDVAQTHPGLRYVVYDIS TATPERLQRTWAAVSELINAAVIEPPPVTAYGLLRARQAFRDISEARPSGKVVLIAPAALDPAGTVLITG GTGMLGGLFAEHLLTHYGVRRLLLTSRRGPSGVGAAELAERLNGLGAQVTISACDCADPAQLAALIDSIP TEHPLTAVIHAAGVLDDAVTSQLTAQQLDTVLAAKADSAWHLHQLTANTELAAFVLFSSAAGVLGAPGQA NYAAANAVLDALARERGPGATSLAWGYWQPSSGMTGHLDARDQARLTRSGMVPITTSAGLALFDAALGVQ HPNLIPAPLSTRALAALARESSLPPIFSALISTRPQAAMADSRALGARLAGLTPEQQHAMLTKLVLTATA AVLAHPDPAAMDPDQPFKDLGIDSLSALELRGALSAQSGVDLPATLIFDHPSPASVAVHLADLLSVAAVP AAAAAQVGKRAAEPADDRLAYLDQAAFLGLRAGYGSLIQMIWIYDRAVDVEGLRRFHRNLGCGLLGRRIE RSPLPFARDRWVSAPVSQQIDFATTPRRRADVGAWADERARLPIDPEWGPGWHLGVVGLDDGGTAVSLVA SHTIADAIAFGQAVVNAAEGRTQDLGYPAAGSRILRRALREDLRQTVNELPKIAHAFGGVVRRLRRDRQE LQSSIKAAPPPPRMAGGDHSVEVPAVTAYIDLADWDACAKRLGAKSNSLVGGVACRLAARVGRVQGDGTV TLRIVVSLRTKDDTRGNALTAVDVAVDPAHAATDLREMHAKITRAILEGMEDLDNEFLAPLPLAAITPRW VARRLVGMAAGGPTLPVTCSNVGDVPPAANRPDGTDADFAYIRLVEPDIAKSVLEGTGGRMLLASGRGRG KMCIGISAYLVGHSNTKDELREVVSRTFAEFGLNAEIDC
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. marinum M | MMAR_1180 | - | - | 100% (3259) | Fatty acyl-AMP ligase FadD28_1 and polyketide synthase |
M. marinum M | MMAR_3798 | - | 0.0 | 54.42% (2117) | type I modular polyketide synthase |
M. marinum M | MMAR_3099 | - | 0.0 | 41.45% (2876) | polyketide synthase and peptide synthetase |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb2074c | pks12 | 0.0 | 46.73% (2108) | polyketide synthase pks12 |
M. gilvum PYR-GCK | Mflv_0405 | - | 0.0 | 35.22% (2331) | beta-ketoacyl synthase |
M. tuberculosis H37Rv | Rv2048c | pks12 | 0.0 | 46.63% (2108) | polyketide synthase pks12 |
M. leprae Br4923 | MLBr_00135 | - | 0.0 | 44.41% (2137) | putative polyketide synthase |
M. abscessus ATCC 19977 | MAB_0939 | - | 0.0 | 34.92% (2305) | polyketide synthase |
M. avium 104 | MAV_2450 | - | 0.0 | 46.82% (2123) | erythronolide synthase, modules 3 and 4 |
M. smegmatis MC2 155 | MSMEG_0408 | - | 0.0 | 35.15% (2310) | type I modular polyketide synthase |
M. thermoresistible (build 8) | TH_4458 | - | 0.0 | 39.42% (1451) | PUTATIVE putative Fatty acyl-AMP ligase FadD28_1 and polyketide |
M. ulcerans Agy99 | MUL_2266 | pks12 | 0.0 | 46.44% (2121) | polyketide synthase, Pks12 |
M. vanbaalenii PYR-1 | Mvan_1003 | - | 0.0 | 36.88% (2329) | beta-ketoacyl synthase |
CLUSTAL 2.0.9 multiple sequence alignment Mflv_0405|M.gilvum_PYR-GCK -----------------------MGSAAHQGE-SAHRFAIVGYAGRFPG- MAB_0939|M.abscessus_ATCC_1997 -----------------------MDSAENPIE-STPRFAIIGYAARFPG- MSMEG_0408|M.smegmatis_MC2_155 -----------------------MVSAEHPIE-PTPSFAIIGYAARFPG- Mvan_1003|M.vanbaalenii_PYR-1 ---------MTDLQKRALQAIEVLRARVRELEGAGDGYAIVGYALRFPG- Mb2074c|M.bovis_AF2122/97 -MVDQLQHATEALRKALVQVERLKRTNRALLERSSEPIAIVGMSCRFPGG Rv2048c|M.tuberculosis_H37Rv -MVDQLQHATEALRKALVQVERLKRTNRALLERSSEPIAIVGMSCRFPGG MUL_2266|M.ulcerans_Agy99 -MVDQLQHATEALRKALVQVERLKRTKRALLERSSEPIAIVGMSCRFPGG MAV_2450|M.avium_104 MMVDQLQHATEALRKALVQVERLKRTNRALLERSSEPIAIVGMSCRFPGG MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MMAR_1180|M.marinum_M -------------------------------------------------- TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK ARDAESFWELLADGRDAISEVPEDR-WDVEAFFDPDPSTPGKVVTRRAGF MAB_0939|M.abscessus_ATCC_1997 AADAEEFWDVLREGRDAISEVPADR-WDAEEFFDPEPGAPGKVVTRRAGF MSMEG_0408|M.smegmatis_MC2_155 AASAEEYWALLRDGREAISDVPKDR-WDIEEFFDPDPSTPGKVVTRRAGF Mvan_1003|M.vanbaalenii_PYR-1 AADADEFWDVLRGGRDAISEVPQDR-WDADEFFDADPEAAGKMVTRRAGF Mb2074c|M.bovis_AF2122/97 VDSPEGLWQMVADARDVMSEFPTDRGWDLAGLFDPDPDVRHKSYARTGGF Rv2048c|M.tuberculosis_H37Rv VDSPEGLWQMVADARDVMSEFPTDRGWDLAGLFDPDPDVRHKSYARTGGF MUL_2266|M.ulcerans_Agy99 VDSPEGLWQMVAEGRDVMSDFPTDRGWDLADLFDPDPDTPHKSYASTGGF MAV_2450|M.avium_104 VDSPEALWQMVAEGRDVISEFPTDRGWDLAALYDPDPDARHKCYVNTGGF MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MMAR_1180|M.marinum_M -------------------------------------------------- TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK VDDVSGFDAPFFGMSTREVRLMDPQHRLLLETAWRAIEHSGTAPSELANT MAB_0939|M.abscessus_ATCC_1997 VEDVTGFDAPFFGMSTREVRLMDPQHRLLLETAWRAVEHSGIAPTDLAET MSMEG_0408|M.smegmatis_MC2_155 VDDVTGFDAPFFGMSAREVRLMDPQHRILMETAWRAVEHSGIAPTSLANS Mvan_1003|M.vanbaalenii_PYR-1 VEDVAGFDAPFFGVSAREAMFMDPQHRLLLETAWRAVEHSGTAPSALAGT Mb2074c|M.bovis_AF2122/97 VDGVADFDPAFFGISPSEALAMDPQHRMLLELSWEALERAGIDPTGLRGS Rv2048c|M.tuberculosis_H37Rv VDGVADFDPAFFGISPSEALAMDPQHRMLLELSWEALERAGIDPTGLRGS MUL_2266|M.ulcerans_Agy99 VDGVADFDPGFFGIAPSEALAMDPQHRMLLELSWEALERSGIDPTGLRGS MAV_2450|M.avium_104 VDNVADFDPAFFGIAPSEALAMDPQHRMLLELSWEALERAGIDPSGLRGS MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MMAR_1180|M.marinum_M --------------------------------------MLDHSISAVLRE TH_4458|M.thermoresistible__bu -------------------------------------------LLSLLRQ Mflv_0405|M.gilvum_PYR-GCK NTGVFVGLATHDYLGMASDELSYPEIEAYMAIGTSNAAAAGRISYRLGLQ MAB_0939|M.abscessus_ATCC_1997 NSGVFVGLATHDYLGMASDELTFPEIEAYMAIGTSNAAAAGRISYRLGLQ MSMEG_0408|M.smegmatis_MC2_155 NTGVFVGLATHDYLGMASDELTYPEIEAYMAIGTSNAAAAGRISYRLGLQ Mvan_1003|M.vanbaalenii_PYR-1 RTGVFMGLSTHDYLGMLTDNLTHDAIEAYLGTGTSPAAAIGRISYRLGLQ Mb2074c|M.bovis_AF2122/97 ATGVFAGLIVGGYG------MLAEEIEGYRLTGMTSSVASGRVAYVLGLE Rv2048c|M.tuberculosis_H37Rv ATGVFAGLIVGGYG------MLAEEIEGYRLTGMTSSVASGRVAYVLGLE MUL_2266|M.ulcerans_Agy99 ATGVFAGLIVQGYG------MFAEEIEGYRLTGMTSSVASGRVAYVLGLE MAV_2450|M.avium_104 ATGVFAGLIVQGYG------MLAEEIEGYRLTGMTSSVASGRVSYVLGLE MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MMAR_1180|M.marinum_M RASLRPSETAFTFIDYERDWAGIAETLTWSQLHRRTCNVARELKACGATG TH_4458|M.thermoresistible__bu RSERYGDKIAFDYCTGEQEHS----RLTYQELDIRARAIAAHLQDQGVAG Mflv_0405|M.gilvum_PYR-GCK GPAVAVDTACSSSLVAIHQACQALRLGECDLALAGGANVILTPATMITFS MAB_0939|M.abscessus_ATCC_1997 GPSVAVDTACSSSLVAIHQACQALQLGECDLALAGGANVLLTPATMITFS MSMEG_0408|M.smegmatis_MC2_155 GPAVAVDTACSSSLVAIHQACQALRLNECDLALAGGANVLLTPATMITFS Mvan_1003|M.vanbaalenii_PYR-1 GPAVAVDTACSSSLVAVHQACQALRLAECDVALAGGVNVLLSPATMINFS Mb2074c|M.bovis_AF2122/97 GPAVSVDTACSSSLVALHMAVGSLRSGECDLALAGGVTVNATPTVFVEFS Rv2048c|M.tuberculosis_H37Rv GPAVSVDTACSSSLVALHMAVGSLRSGECDLALAGGVTVNATPTVFVEFS MUL_2266|M.ulcerans_Agy99 GPAVSVDTACSSSLVALHMAVQSLRSGECDLALAGGATVNATPTVFVEFS MAV_2450|M.avium_104 GPAVSVDTACSSSLVALHMAVQSLRSGECDLALAGGATVNATPTVFVEFS MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MMAR_1180|M.marinum_M DRAVVLAPQGLDYIVAFLGALQAGQIAVPLSAPLGGASDERVGSVLRDAL TH_4458|M.thermoresistible__bu ERVLVLCPSGLDFITAMFGCFYVGAVAVPVHPPVHNRLLSRVASIVADVR Mflv_0405|M.gilvum_PYR-GCK NAHMLAPDGRCKTFDAAADGYVRGEGCGVIVIKRLEDAVRDGDRIRAVIR MAB_0939|M.abscessus_ATCC_1997 HAHMLAPDGKCKTFDAAADGYVRGEGSGVIVIKRLEDAIRDGDRIRAVIR MSMEG_0408|M.smegmatis_MC2_155 NAHMLAPDGRCKTFDAAADGYVRGEGCGVVVVKRLEDAVRDGDRIRAVIR Mvan_1003|M.vanbaalenii_PYR-1 RARMLAPDGRCKTFDATADGYVRGEGCGVVVVKRLADAIRHGDRIRAVIR Mb2074c|M.bovis_AF2122/97 RHRGLAPDGRCKPYAGRADGVGWSEGGGMLVLQRLSDARRLGHPVLAVVV Rv2048c|M.tuberculosis_H37Rv RHRGLAPDGRCKPYAGRADGVGWSEGGGMLVLQRLSDARRLGHPVLAVVV MUL_2266|M.ulcerans_Agy99 RHRGLAPDGRSKAYAGAADGVGWSEGGAMLVVERLSDAQRLGHPVLALVR MAV_2450|M.avium_104 RHRGLAPDGRCKAYAGAADGVGWSEGGAMLVVERLSDARRLGHPVLAVVR MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MMAR_1180|M.marinum_M PSAILTTSPIAGDVAECITLTPGKRAPSVIEIDLLDPDSGQGPAAESDSG TH_4458|M.thermoresistible__bu ATSVLTTAATRADLKEILDGLHDGDPLRWLAVDTIEADDETSWTPTTVDT Mflv_0405|M.gilvum_PYR-GCK GSAINQDGASGGLTVPNGVAQQRVIGDALSRAGLAPGDVDYLEAHGTGTS MAB_0939|M.abscessus_ATCC_1997 GSAINQDGASGGLTVPNGVAQQRVIADALKRAGVAPSEVGYLEAHGTGTS MSMEG_0408|M.smegmatis_MC2_155 GSAINQDGASGGLTVPNGVAQQRVIADALKRAGLRPADVGYLEAHGTGTS Mvan_1003|M.vanbaalenii_PYR-1 GSAVNQDGASGGLTVPNGAAQQRVIADALTNAGLTAADVDYLEAHGTGTP Mb2074c|M.bovis_AF2122/97 GSAVNQDGASNGLTAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTT Rv2048c|M.tuberculosis_H37Rv GSAVNQDGASNGLTAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTT MUL_2266|M.ulcerans_Agy99 GSAVNQDGASNGLTAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTT MAV_2450|M.avium_104 GSAVNQDGASNGLTAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTT MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MMAR_1180|M.marinum_M SDIAYLQYTSGSTRTPAGVVVSHRNLLANVEQGMSAYFGDHGRAAPPDTT TH_4458|M.thermoresistible__bu DSVAFVQYTSGSTSTPKGVVLTHHNLLANLES-ISRDAGQG-----DEAR Mflv_0405|M.gilvum_PYR-GCK LGDPIEAQAAGAALGPGREPQ----RPLLIGSAKTNIGHLEAAAGIAGVI MAB_0939|M.abscessus_ATCC_1997 LGDPIEAQAAGAAYGIGRETN----DPLLIGSAKTNIGHLEAAAGIAGVI MSMEG_0408|M.smegmatis_MC2_155 LGDPIEAQAAGEVLGAGRAPE----EPLLIGSAKTNIGHLEAAAGIAGVI Mvan_1003|M.vanbaalenii_PYR-1 LGDPIEVQAAGAVLGVGREPD----RPLLIGSVKTNIGHLEAASGIAGLL Mb2074c|M.bovis_AF2122/97 LGDPIEAQALLATYGQDRGEP---GEPLWLGSVKSNMGHTQAAAGVAGVI Rv2048c|M.tuberculosis_H37Rv LGDPIEAQALLATYGQDRGEP---GEPLWLGSVKSNMGHTQAAAGVAGVI MUL_2266|M.ulcerans_Agy99 LGDPIEAQALLATYGQDRGSAGAAGKALWLGSIKSNMGHTQAAAGVAGVI MAV_2450|M.avium_104 LGDPIEAQALLATYGQDRGQP------LWLGSIKSNMGHTQAAAGVAGVI MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MMAR_1180|M.marinum_M VVS--------------------------------WLPFFHDMGLMFGII TH_4458|M.thermoresistible__bu VVS--------------------------------WLPLHHDMGLIGGIF Mflv_0405|M.gilvum_PYR-GCK KVVLSLEHETLPKHLNFENPSPHIPWDRLPVEVVKESIPWRRGQRGGRPR MAB_0939|M.abscessus_ATCC_1997 KVILSLENELLPQHRNFQNPSPHIPWDRLPVEVVREARPWGR---NGRPR MSMEG_0408|M.smegmatis_MC2_155 KVVMALENETLPKHLNFETPSPHIPWERLPIEVVRETVPWQR---NGKPR Mvan_1003|M.vanbaalenii_PYR-1 KVILSLEHQVLPKHLNFRSPSPHIPWNRLPVRIVDDPVPWTR---SGRSR Mb2074c|M.bovis_AF2122/97 KMVLAMRHELLPATLHVDVPSPHVDWSAGAVELLTAPRVWP---AGARTR Rv2048c|M.tuberculosis_H37Rv KMVLAMRHELLPATLHVDVPSPHVDWSAGAVELLTAPRVWP---AGARTR MUL_2266|M.ulcerans_Agy99 KMVQAMRHEVLPATLHVDVPSPHVDWSAGAVELLTEAQPWPAESAGDRVR MAV_2450|M.avium_104 KMVLAMRHELLPATLHVDEPSPHVDWSAGAVSLLTEAQPWP----GERPR MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MMAR_1180|M.marinum_M MPLLEGFHSVLTSPISFLQR------------------------------ TH_4458|M.thermoresistible__bu GVVHFGGTAYLMPPSSFIQR------------------------------ Mflv_0405|M.gilvum_PYR-GCK IAGVSSFGFAGTNAHVILEEAPLAAEPAQES---VDDGRFTLLPLSARTP MAB_0939|M.abscessus_ATCC_1997 IAGVSSFGFAGTNAHVILEEAPVVSRDAVEPPAPAGGRKFSILPLSARTP MSMEG_0408|M.smegmatis_MC2_155 IAGVSSFGFAGTNAHVILEEAPAVGTPATTEP-VEDPRRYSVLPLSARTP Mvan_1003|M.vanbaalenii_PYR-1 VAGISSFGFSGTNAHVLVEEAPRADRAGAAPQ-PAAPGGFGMLPLSARTP Mb2074c|M.bovis_AF2122/97 RAGVSSFGISGTNAHVIIEAVPVVPRR-EAGWAGPVVP----WVVSAKSE Rv2048c|M.tuberculosis_H37Rv RAGVSSFGISGTNAHVIIEAVPVVPRR-EAGWAGPVVP----WVVSAKSE MUL_2266|M.ulcerans_Agy99 RAGVSSFGISGTNAHVIVEAAPRVEVGGSSGGAVPVVP----WVVSAKSG MAV_2450|M.avium_104 RAGVSSFGISGTNAHVIIEAVPAVEPAHADAPALPVLP----WVVSAKSA MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MMAR_1180|M.marinum_M -------------------------------------------------- TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK AALMAVADRYRDWLVANPDATLADLCFTAGTARSHLEHRAALVVNTREAA MAB_0939|M.abscessus_ATCC_1997 AALAQLADKYRAWLNAHPEAALADLCFTAGVGRAHLEHRAALVVNTREAA MSMEG_0408|M.smegmatis_MC2_155 EALVRLAGEYRDWLRAHPQARLADVSHTAGTARAHLEQRAALVVNSRESA Mvan_1003|M.vanbaalenii_PYR-1 DALAATAHRLRTWLAANPDASWPDLCFTAAVGRSHLRHRAALVVDSRSSV Mb2074c|M.bovis_AF2122/97 SALRGQAARLAAYVRGDDGLDVADVGWSLAG-RSVFEHRAVVVGGDRDRL Rv2048c|M.tuberculosis_H37Rv SALRGQAARLAAYVRGDDGLDVADVGWSLAG-RSVFEHRAVVVGGDRDRL MUL_2266|M.ulcerans_Agy99 SALGAQAARLAAHVRSHDELDVADVGWSLAG-RSTFEHRAVVLGADRDGL MAV_2450|M.avium_104 AALRAQAARLAEYVRAQGELDIADVGWTLAG-RATFEHRAVVVGGDRDRL MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MMAR_1180|M.marinum_M -------------------------------------------------- TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK LDLLGALADDRPA-PGLVRGESHDTPKTAWLFTGQGSQYPGMSRELFDTE MAB_0939|M.abscessus_ATCC_1997 VELLSAVADDRPA-PGLGRGESHDTPKTAWLFTGQGSQYPGMARELFETE MSMEG_0408|M.smegmatis_MC2_155 IELLGALADDRPA-PGLVRGESHEAPKTAWLFTGQGSQYPGMARELFDTE Mvan_1003|M.vanbaalenii_PYR-1 EELLGALAEDRPG-PGLARGECGDPPKTAWLFTGQGSQYPGMGRELFDTE Mb2074c|M.bovis_AF2122/97 LAGLDELAGDQLG-GSVVRGTATAAGKTVFVFPGQGSQWLGMGIELLDTA Rv2048c|M.tuberculosis_H37Rv LAGLDELAGDQLG-GSVVRGTATAAGKTVFVFPGQGSQWLGMGIELLDTA MUL_2266|M.ulcerans_Agy99 LAGLDELAGDEFGGASVIRGVAGAAGKTVFVFPGQGSQWIGMGIELLDTA MAV_2450|M.avium_104 LAGLDELAADDPA-ASIIRGVATPAGKTVFVFPGQGSQWLGMATELLDTA MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MMAR_1180|M.marinum_M --------------------------------PARWMQLLASNCQVFSAA TH_4458|M.thermoresistible__bu --------------------------------PMSWLEAISWHGANISVG Mflv_0405|M.gilvum_PYR-GCK PLFAETLRECAAAVDGMLEKPLLDVIFDTDGVLDTDSNETLRHTSYAQPA MAB_0939|M.abscessus_ATCC_1997 PVFADTLNRCAAAVADVLEKPLLDVIFDVD---GPEAEETLRQTSYAQPA MSMEG_0408|M.smegmatis_MC2_155 PVFAETVRKCAEAVADILEKPLLDVIFDAD-ELDGDTESPLRHTTYAQPA Mvan_1003|M.vanbaalenii_PYR-1 PVYREVMTRCAEAVADVLERPLLDVVFDAD------GGEALRHTSYAQPA Mb2074c|M.bovis_AF2122/97 PAFAQQIDACAEAFAEFVDWSLVDVLRGAP------GAPGLDRVDVVQPV Rv2048c|M.tuberculosis_H37Rv PAFAQQIDACAEAFAEFVDWSLVDVLRGAP------GAPGLDRVDVVQPV MUL_2266|M.ulcerans_Agy99 PVFARHIESCGQAFAEFVDWSLLDVLRGAA------GAPGLDRIDVVQPV MAV_2450|M.avium_104 PVFAQHIQACEEAFAEFVDWSLIDALRGAP------GAAGMDRVDVVQPA MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MMAR_1180|M.marinum_M PNIAFELAARKTSDDDLAGLDLGGVRNILSG---------------AERV TH_4458|M.thermoresistible__bu PNFGYQLCVERSTPEERATLDLSTWVRAYCG---------------AEPV Mflv_0405|M.gilvum_PYR-GCK LFAVEMGLARLWQSWGFEPDVVLGHSVGQYAAACVAGVLSLRDGARLMAE MAB_0939|M.abscessus_ATCC_1997 LFAVEMGLARLWQSWGFEPDVVLGHSVGQYSAACVAEVFSLEDGARLIAE MSMEG_0408|M.smegmatis_MC2_155 LFAVELGLARLWQSWGFEPDVVVGHSVGQYSAACVAGVFDVEDGARLIAE Mvan_1003|M.vanbaalenii_PYR-1 LYAVEMGLARLWQSWGIEPDVVLGHSVGQYAAACVAGVMGLEDGAVLLAE Mb2074c|M.bovis_AF2122/97 LFAVMVSLAELWKSVAVHPDAVIGHSQGEIAAAYVAGALSLRDAARVVTL Rv2048c|M.tuberculosis_H37Rv LFAVMVSLAELWKSVAVHPDAVIGHSQGEIAAAYVAGALSLRDAARVVTL MUL_2266|M.ulcerans_Agy99 LFAVMVSLAELWKSVGVRPDAVIGHSQGEIAAAYVAGALSLRDAAKVVTL MAV_2450|M.avium_104 LFAVMVSLAELWKSVGVSPDAVIGHSQGEIAAAYVAGALSLRDAARVVTL MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MMAR_1180|M.marinum_M QPATLARFAQRFARFHLHPRALRPSYGLAEATVFVA-------------- TH_4458|M.thermoresistible__bu RAATMRRFTEAFAPAGFRADAFHPVYGLAEATLFVS-------------- Mflv_0405|M.gilvum_PYR-GCK RGRLFGSLPSGGRMAAVFAAAERVEALTDEYPALS--VAAYNGANTVLSG MAB_0939|M.abscessus_ATCC_1997 RGRLFSSLPAGGRMAAVFTDAERAERLTDEFPSLS--VAAYNGANTVLSG MSMEG_0408|M.smegmatis_MC2_155 RGRLFGSLPAGGRMAAVFTAPERAERLTDEYPSLS--VAAYNGANTVLSG Mvan_1003|M.vanbaalenii_PYR-1 RGRLFGSLPEGGRMAAVFAPADRVESCTVDSPLLS--VAAYNGDNTVLSG Mb2074c|M.bovis_AF2122/97 RSKLLAGLAGPGGMVSIACGADQARDLLAPFGDRVSIAVVNGPSAVVVSG Rv2048c|M.tuberculosis_H37Rv RSKLLAGLAGPGGMVSIACGADQARDLLAPFGDRVSIAVVNGPSAVVVSG MUL_2266|M.ulcerans_Agy99 RSKLLVGLAGPGGMVSVACGEQQARELLEPFGDRVSIAAINGPSAVVVSG MAV_2450|M.avium_104 RSKLLRSLAGPGGMLSIACSTERARELLAPYGNRVSIAAVNGRSAVVVSG MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MMAR_1180|M.marinum_M -TREWGQPPVTVYFDSDELTAGHAKRCATGTG--TALISYG-AAQSPTVR TH_4458|M.thermoresistible__bu -GRPENVLPTVRSLDNAALREHRVVPAAADDANAAAVVGCGPAAYGEEIV Mflv_0405|M.gilvum_PYR-GCK PATDLERAVAGLVADGVRCDWLETSHAFHSALLDPILDDFESYARGITFT MAB_0939|M.abscessus_ATCC_1997 PAQDLEKAIAALVADGVRCDFLETSHAFHSALLDPILDEFEAYANQFNYK MSMEG_0408|M.smegmatis_MC2_155 PAKDLESAVATLVADGVRCDWLDTSHAFHSALLDPILDDFESFAQKLEYR Mvan_1003|M.vanbaalenii_PYR-1 PAGDLERAVAGFSAAGVRCDWLDTSHAFHSALLDPVLEEFESCADRFEFG Mb2074c|M.bovis_AF2122/97 EVGALEELIAVCSTKELRTRRIEVDYASHSVEVEAIRGPLAEALSGIEPR Rv2048c|M.tuberculosis_H37Rv EVGALEELIAVCSTKELRTRRIEVDYASHSVEVEAIRGPLAEALSGIEPR MUL_2266|M.ulcerans_Agy99 EVAALEELIAQCADRELRTRRIDVDYASHSVEVEAIEGQLTEVLAGIEPL MAV_2450|M.avium_104 EGAALDELAAFCADLALRTRRIDVDYASHSVEVEAIREDLAQALTGIEPR MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MMAR_1180|M.marinum_M IVDPQTATECPAGVVGEIWVHGDNVAAGYWHRPQETERTFGATLVGPSPG TH_4458|M.thermoresistible__bu IVDPATRREFPPDVVGEIWVAGENVAQGYLGKPSESAETFAAHLADSGR- Mflv_0405|M.gilvum_PYR-GCK APQRILIDNRTG----AALGRSVTLDAAYWRRHARQPVEFAKSVHTLADM MAB_0939|M.abscessus_ATCC_1997 TPQRILIDNRTG----TALGRSVKLDGAYWRRHARQPVEFAKSVRTLADM MSMEG_0408|M.smegmatis_MC2_155 EPQRILIDNRTG----SALGRSTRLDGAYWRRHARQPVEFAKSVRTLADM Mvan_1003|M.vanbaalenii_PYR-1 TPQRTLVCNRSG----EVLSRHARLDGQYWRRHARQPVRFAESVRTLADL Mb2074c|M.bovis_AF2122/97 STRTVFFSTVTG----NRLD-TAGLDADYWYRNVRQTVLFDQAVRNACEQ Rv2048c|M.tuberculosis_H37Rv STRTVFFSTVTG----NRLD-TAGLDADYWYRNVRQTVLFDQAVRNACEQ MUL_2266|M.ulcerans_Agy99 SSRTAFFSSVTG----SRLD-TAELDAEYWYRNIRQTVQFDQAVRSACGH MAV_2450|M.avium_104 SSRIAFFSTVTG----NRLD-TAGLDADYWYRNIRQTVQFDQTVRSAAEH MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MMAR_1180|M.marinum_M TPPGPWLRTGDLGAFSE--------------------------------- TH_4458|M.thermoresistible__bu ---GPFLRTGDYGFLLD--------------------------------- Mflv_0405|M.gilvum_PYR-GCK NCKLLVEIGPRPVLTAAALSAWPDPATSP----RVIASLRRTTADQRQIT MAB_0939|M.abscessus_ATCC_1997 NCKVLLEIGPQPVLTAAALRAWPDPATAP----RAIASLRRNTADHRQIT MSMEG_0408|M.smegmatis_MC2_155 NCRVLLEIGPRPVLTATALAAWPDPATTP----QVLASLRPTTADHRQIT Mvan_1003|M.vanbaalenii_PYR-1 GCRLLMEIGPQPVLTAAAMRTWPGTVTAP----RVAASMRRKGSDRRQIT Mb2074c|M.bovis_AF2122/97 GYRTFIESSPHPALITGVEETFAACTDGD-SEAIVVPTLGRGDGGLHRFL Rv2048c|M.tuberculosis_H37Rv GYRTFIESSPHPALITGVEETFAACTDGD-SEAIVVPTLGRGDGGLHRFL MUL_2266|M.ulcerans_Agy99 GYRTFIESSPHPALIAGIEDTYRNCAADSGADPIVVPTLGREDGGLQRFL MAV_2450|M.avium_104 GYRTFIESSPHPALVAGIEDTVNDSLPGD-TEAIVIPTLGRDDGGLERFL MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MMAR_1180|M.marinum_M -------------------------------------------------- TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK EAVADAYVLGHLPRFAAFRRDGARVLDLPTYPFEHRQYWFSDSRE---PV MAB_0939|M.abscessus_ATCC_1997 EAAADAYVLGHLPDFGAFQHAPARKLDLPTYPFERRQYWFSDKRDGDNRD MSMEG_0408|M.smegmatis_MC2_155 EAVAAAYAAGHLPDFRAFRQPDARKLDLPTYPFEHRQFWFSDNRAIDRDT Mvan_1003|M.vanbaalenii_PYR-1 EALAQAYVAGHRPETAARQHGRGRLLDLPTYPFQHRAYWFP--------Q Mb2074c|M.bovis_AF2122/97 LSAASAFVAGVAVNWRGTLDG-AGYVELPTYAFDKRRFWLSAEGSGADVS Rv2048c|M.tuberculosis_H37Rv LSAASAFVAGVAVNWRGTLDG-AGYVELPTYAFDKRRFWLSAEGSGADVS MUL_2266|M.ulcerans_Agy99 ASAAAAFVAGVNVDWRGPLDG-AGLVELPTYAFEKRRFWLSGEGVSVDAS MAV_2450|M.avium_104 TSAATAFVAGVNVAWRGVLDG-AGFVELPTYAFDRRRFWLSGEGAAADAS MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MMAR_1180|M.marinum_M -------------------------------------------------- TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK AAAPQR---GARTETVRLLEDGRIEELAALLGGTV--------------- MAB_0939|M.abscessus_ATCC_1997 AGNRQQNNGGPRTEAVRLLEDGKIEELANLLGGVD--------------- MSMEG_0408|M.smegmatis_MC2_155 QTASAGSVTPHRTQAVRLLEDGQIEELAALIDGET--------------- Mvan_1003|M.vanbaalenii_PYR-1 GQARTAPTDPVHTETVRFLDEERIDELAALLDGPT--------------- Mb2074c|M.bovis_AF2122/97 GLGLGASEHPLLGAVVDLPASGGVVLTGRLSPNVQPWLADHAVSDVVLFP Rv2048c|M.tuberculosis_H37Rv GLGLGASEHPLLGAVVDLPASGGVVLTGRLSPNVQPWLADHAVSDVVLFP MUL_2266|M.ulcerans_Agy99 GLGLSAGGHALLGAVVELPESGGVVLTGRLALGAHGWLADHAVSGVVVFP MAV_2450|M.avium_104 GLGLGTSEHPLLSAVVELPASGGVVLTGRLSPSLQGWLTDHAVSGTVVFP MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MMAR_1180|M.marinum_M -------------------------------------------------- TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK ----------------------------------------DDPFTFDVLN MAB_0939|M.abscessus_ATCC_1997 ----------------------------------------GDQQTLNVLT MSMEG_0408|M.smegmatis_MC2_155 ----------------------------------------VDEQTLRVLN Mvan_1003|M.vanbaalenii_PYR-1 ----------------------------------------GSAQTVDVLS Mb2074c|M.bovis_AF2122/97 GTGFVELAIRAGDEVGCSVLDELTLAAPLLLPAT----GSVAVQVVVDAG Rv2048c|M.tuberculosis_H37Rv GTGFVELAIRAGDEVGCSVLDELTLAAPLLLPAT----GSVAVQVVVDAG MUL_2266|M.ulcerans_Agy99 GTGFVELAIRAVDEVGCSVVNELTLRTPLVLPAS----GSVAVQVVVGAA MAV_2450|M.avium_104 GAGFVELAIRAGDEVGCSTVEELTLQAPLMLPAKDSGIGSVAVQVLVGEA MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MMAR_1180|M.marinum_M -------------------------------------------------- TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK RLAAQHNQQRSTESIADDR------YQIRWETAAEPPVGADAADGITWLL MAB_0939|M.abscessus_ATCC_1997 KLAAQHNLQRTTQTIADDR------YQFRWEKSPTPLSGSQAAGGVTWLL MSMEG_0408|M.smegmatis_MC2_155 KLAARHNQQRSTHVDPDAR------YEIRWDAIASAAASTGAAA--DWIL Mvan_1003|M.vanbaalenii_PYR-1 KLAARHRQQRGAQSIADAR------YQIRWEKSEAPGAARPTTEATTWLL Mb2074c|M.bovis_AF2122/97 RDSNSRGVSIFSRADAQAG------WLLHAEGILRPGSVEPGADLSVWPP Rv2048c|M.tuberculosis_H37Rv RDSNSRGVSIFSRADAQAG------WLLHAEGILRPGSVEPGADLSVWPP MUL_2266|M.ulcerans_Agy99 ADSAERSVSIYSRTDTDTDTDAGSVWVCHAEGTLGADSAQPAADLSAWPP MAV_2450|M.avium_104 DESGRRDVSIFSRPDSDSP------WVCHAQGTLSTGSIEPGADLAAWPP MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MMAR_1180|M.marinum_M -------------------------------------------------- TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK VGDDTDATRPLVDVLAARGHRY---------------------------- MAB_0939|M.abscessus_ATCC_1997 VADAAGAAQPLLDVLTARGQQH---------------------------- MSMEG_0408|M.smegmatis_MC2_155 VGDDTAAVLEFADALTAGGHRH---------------------------- Mvan_1003|M.vanbaalenii_PYR-1 VTHDSRAAQPIAEVLERRGHPY---------------------------- Mb2074c|M.bovis_AF2122/97 AGAVTVDVADGYERLATRGYRYGPAFRGLTAMWARGEEIFAEVRLPEAAG Rv2048c|M.tuberculosis_H37Rv AGAVTVDVADGYERLATRGYRYGPAFRGLTAMWARGEEIFAEVRLPEAAG MUL_2266|M.ulcerans_Agy99 AGAIAVDVADGYERLDARGYGYGPAFRGLTAMWARGEELFAEARLPEAAG MAV_2450|M.avium_104 AGATKVDIADGYQRLAARGYGYGPAFQGLTAAWVRGDEVFAEVRLPDAAG MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MMAR_1180|M.marinum_M --GELFIIGRIKDLLIIYGRNHS--------------------------- TH_4458|M.thermoresistible__bu --GELFVTGRLKDLIIIRGRNYH--------------------------- Mflv_0405|M.gilvum_PYR-GCK -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_1003|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb2074c|M.bovis_AF2122/97 GVGGFGVHPALLDAVLHAVVI----AGDPDELALPFAWQGVSLHATGASA Rv2048c|M.tuberculosis_H37Rv GVGGFGVHPALLDAVLHAVVI----AGDPDELALPFAWQGVSLHATGASA MUL_2266|M.ulcerans_Agy99 STSGFGVHPALLDAALHTAVI----ANPDADLVLPFSWQGVSLHAAGAAS MAV_2450|M.avium_104 GVTGFGVHPALLDAAMHALIVGHQIAGDTDEVALPFAWQGVSLHAAGASA MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MMAR_1180|M.marinum_M -------------------------------------------------- TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK --------------------------------RILGLPKSGAEEHELADT MAB_0939|M.abscessus_ATCC_1997 --------------------------------RVLALPVSDADEAELVEA MSMEG_0408|M.smegmatis_MC2_155 --------------------------------QIVALPGSDADEAQLVDT Mvan_1003|M.vanbaalenii_PYR-1 --------------------------------HIVGLPGSDADAAPAEEA Mb2074c|M.bovis_AF2122/97 VRARIAPAGPS------AVSVELADGLGLPVLSVASMVARPVTERQLLAA Rv2048c|M.tuberculosis_H37Rv VRARIAPAGPS------AVSVELADGLGLPVLSVASMVARPVTERQLLAA MUL_2266|M.ulcerans_Agy99 VRVRIAPVGPS------SVSVELADDLGLPVLSVKAMVARPVSEQQMRAV MAV_2450|M.avium_104 VRARLAPAQAPGTAASRAVSLELADGLGLPVLSVRAMVARSVSERQLRAA MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MMAR_1180|M.marinum_M -------------------------------------------PDDIEAT TH_4458|M.thermoresistible__bu -------------------------------------------PNDIEAT Mflv_0405|M.gilvum_PYR-GCK LRDAAADATDLRIVHVAALDAAESDTSMKSLLRMQHRVLGGTRRLFGAAV MAB_0939|M.abscessus_ATCC_1997 LRSAADEDSALRIVHVAALAGQGS-SSAQSLLRIQHQVLGGTRRLFRAAA MSMEG_0408|M.smegmatis_MC2_155 LRAASAG--ELYVVHIAAGDGAAA--PMRDLLRVQHRTLGGLRRLFRAAN Mvan_1003|M.vanbaalenii_PYR-1 LRATVSQ-PRPHILYLAALEEPGG-SAAETLGWMQHRVLAAARRLFQLAA Mb2074c|M.bovis_AF2122/97 VSGSGPDRLFEVIWSPASAATSPGPTPAYQIFESVAADQDPVAGSYVRSH Rv2048c|M.tuberculosis_H37Rv VSGSGPDRLFEVIWSPASAATSPGPTPAYQIFESVAADQDPVAGSYVRSH MUL_2266|M.ulcerans_Agy99 VSASGPDRLFEVVWTPMTVAAT-DAAPAYELFESIAADGDPLSGTYQRTH MAV_2450|M.avium_104 VSAAGPDRLFEVAWAPVTVPAAHGEPPVHQVFESLAAEGDPVGESYRRTH MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MMAR_1180|M.marinum_M IQEVT----RGRCVAIAV-PDDGGVEKLVVIVEFKTRETS---------- TH_4458|M.thermoresistible__bu VQEVHPALMSGRGAAFAVSPDPSGTEQLVIVQEVDRGRLG---------- Mflv_0405|M.gilvum_PYR-GCK AAQLRSPMWLVTRGA----------QHVTDTDVVAPDQTCLWGFGRAASL MAB_0939|M.abscessus_ATCC_1997 AAELRAPIWIVTRGA----------QHVIEGDTVAPEQSALWGFGRAAAL MSMEG_0408|M.smegmatis_MC2_155 DAELRSPIWLVTRDG----------QRVTDTDTVVPEQSCLWGFGRAAAL Mvan_1003|M.vanbaalenii_PYR-1 TAGARAPIWLITAGA----------QRITGDETVEPAQTSLWGFGRAAAL Mb2074c|M.bovis_AF2122/97 QALAAVQSWLTDHESGVLVVATRGAMALPREDVADLAGAAVWGLVRSAQT Rv2048c|M.tuberculosis_H37Rv QALAAVQSWLTDHESGVLVVATRGAMALPREDVADLAGAAVWGLVRSAQT MUL_2266|M.ulcerans_Agy99 QALAAVQSWLTEHDSGVLVVATRGAMALAGEDVTDLAGAAVWGLVRSAQT MAV_2450|M.avium_104 EALAAVQSWLTEHDSGVLVVVTRGAMALAGEDVTDLSGAAVWGLVRSAQT MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MMAR_1180|M.marinum_M -------------------------------------------------- TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK EHP----------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 ELP----------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 ELP----------------------------------------------- Mvan_1003|M.vanbaalenii_PYR-1 EQP----------------------------------------------- Mb2074c|M.bovis_AF2122/97 EHPGRIVLVDSDAATDDAAIAMALATGEPQVVLRGGQVYTARVRGSRAAD Rv2048c|M.tuberculosis_H37Rv EHPGRIVLVDSDAATDDAAIAMALATGEPQVVLRGGQVYTARVRGSRAAD MUL_2266|M.ulcerans_Agy99 ENPGRLVLVDSDAAVDAAAVATALAVGEPQVVLRNGQPYTARVHASRAAD MAV_2450|M.avium_104 EHPGRIVLIDSDAALDDSALTAALATGEPQVLLRDGTVYTARVHGSRAVD MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MMAR_1180|M.marinum_M -------------------------------------------------- TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK ------QIWGGLADLGGGTSDEWSRLLNRIAATHDPAVMEDQVAVRGSTS MAB_0939|M.abscessus_ATCC_1997 ------QVWGGLADLSDAGTDEWAQFIGRVSVSGEASTREDQLALRGQAV MSMEG_0408|M.smegmatis_MC2_155 ------HIWGGLADLSGADT-EWPRLIARITSPRDG---EDQIALRGDAV Mvan_1003|M.vanbaalenii_PYR-1 ------ELWGGLADVTTGDAEEWSALIDHIVAAPTS---EDQIAVRGREI Mb2074c|M.bovis_AF2122/97 AILVPPGDGPWRLGLGSAGTFENLRLEPVPNADAPLGPGQVRVAMRAIAA Rv2048c|M.tuberculosis_H37Rv AILVPPGDGPWRLGLGSAGTFENLRLEPVPNADAPLGPGQVRVAMRAIAA MUL_2266|M.ulcerans_Agy99 GILVPPVDGPWRLGLSSAGTFENLQLEPVPNAGAPLGPGQVRVAMRAIAA MAV_2450|M.avium_104 GIMTPPEDRPWRLGISSAGTFENLQLEPVPNPDAALQPGQVRVALRAIAT MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MMAR_1180|M.marinum_M -------------------------------------------------- TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK YVPRLVHRDTLPSGKPLHLRADA--------------------------- MAB_0939|M.abscessus_ATCC_1997 HVPRLVRREELPSGKPLEVRSDA--------------------------- MSMEG_0408|M.smegmatis_MC2_155 YAPRLVRRTGEPSDTPLPVREDR--------------------------- Mvan_1003|M.vanbaalenii_PYR-1 HVARLTRCAEKANAAALELRREA--------------------------- Mb2074c|M.bovis_AF2122/97 NFRDIMITLGMFTHDALLGGEGAGVVVEVGPGVTEFSVGDSVFGFFPDGS Rv2048c|M.tuberculosis_H37Rv NFRDIMITLGMFTHDALLGGEGAGVVVEVGPGVTEFSVGDSVFGFFPDGS MUL_2266|M.ulcerans_Agy99 NFRDIMITLGMFTHDALIGGEGAGVVVEIGPEVTEFAVGDAVYGFFPDGS MAV_2450|M.avium_104 NFRDVMITLGMFTHDALLGGEGAGVVVEVGPGVTEFSVGDSVYGFFPDGS MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MMAR_1180|M.marinum_M -------------------------------------------------- TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_1003|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb2074c|M.bovis_AF2122/97 GTLVAGDVRLLLPMPADWSYAEAAAISAVFTTAYYAFIHLADVQPGQRVL Rv2048c|M.tuberculosis_H37Rv GTLVAGDVRLLLPMPADWSYAEAAAISAVFTTAYYAFIHLADVQPGQRVL MUL_2266|M.ulcerans_Agy99 GTLVAGDVRLLLPKPADWSYAEAAAISAVFTTAYYAFVHLANVQPGQRVL MAV_2450|M.avium_104 GTLVPGDVRLLQHKPTHWSYPEAAGISAVFTTAYMAFIHLADVKPGQRVL MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MMAR_1180|M.marinum_M -------------------------------------------------- TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_1003|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb2074c|M.bovis_AF2122/97 IHAGTGGVGMAAVQLARHLGLEVFATASKGKWDTLRAMGFDDDHISDSRS Rv2048c|M.tuberculosis_H37Rv IHAGTGGVGMAAVQLARHLGLEVFATASKGKWDTLRAMGFDDDHISDSRS MUL_2266|M.ulcerans_Agy99 VHAATGGVGMAAVQLARHLGLEVYATASKGKWDILRAMGFDEDHISDSRS MAV_2450|M.avium_104 VHAAAGGVGMAAVQLARHLGLEVFATASRGKWDTLRAMGFDDDHIGDSRT MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MMAR_1180|M.marinum_M -------------------------------------------------- TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_1003|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb2074c|M.bovis_AF2122/97 LEFEDKFRAATGGRGFDVVLDSLAGEFVDASLRLVAPGGVFLEMGKTDIR Rv2048c|M.tuberculosis_H37Rv LEFEDKFRAATGGRGFDVVLDSLAGEFVDASLRLVAPGGVFLEMGKTDIR MUL_2266|M.ulcerans_Agy99 LEFEEKFREVTGGRSVDVVLDSLAGEFVDASLRLLGPGGVFLEMGKTDIR MAV_2450|M.avium_104 LEFEDKFRSATGGAGMDVVLDSLAGEFVDASLRLVAPGGVFLEMGKTDIR MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MMAR_1180|M.marinum_M -------------------------------------------------- TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_1003|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb2074c|M.bovis_AF2122/97 DPGVIAQQYPGVRYRAFDLFEAGPDRIAQILAELATLFGDGVLRPLPVTT Rv2048c|M.tuberculosis_H37Rv DPGVIAQQYPGVRYRAFDLFEPGRPRMHQYMLELATLFGDGVLRPLPVTT MUL_2266|M.ulcerans_Agy99 DPGVIAQEYPGVRYRAFDLFEPGRPRMHQYMLDLAGLFDAGVLRPLPVTA MAV_2450|M.avium_104 DPGVVAREYPGVRYRAFDLFEPGRPRMRQWMVELAGLFDAGVLNPLPVTT MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MMAR_1180|M.marinum_M -------------------------------------------------- TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK -------------------------------------TYLVTGGLGSLGL MAB_0939|M.abscessus_ATCC_1997 -------------------------------------TYLVTGGLGSIGL MSMEG_0408|M.smegmatis_MC2_155 -------------------------------------TYLVTGGLGAIGL Mvan_1003|M.vanbaalenii_PYR-1 -------------------------------------TYLVTGGLGALGL Mb2074c|M.bovis_AF2122/97 FDVRRAPAALRYLSQARHTGKVVMLMPG----SWAAGTVLITGGTGMAGS Rv2048c|M.tuberculosis_H37Rv FDVRRAPAALRYLSQARHTGKVVMLMPG----SWAAGTVLITGGTGMAGS MUL_2266|M.ulcerans_Agy99 FDVRRAPAALRYLSQARHVGKVVMTMPADQGGALGGGTVLITGGTGMAGS MAV_2450|M.avium_104 FDIRRGRAALRYLSQARHIGKVVMTVPG----ALSAGTVLITGGTGMAGS MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MMAR_1180|M.marinum_M -------------------------------------------------- TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK EIAGYLAA-NGAGHLVLTSRRTPDEAAASRIEALRERHGCEVRVVTADVA MAB_0939|M.abscessus_ATCC_1997 EIAGYLAG-RGAKHLVLTSRREPGEAARQRIDALAA-QGCEVRAVTADVA MSMEG_0408|M.smegmatis_MC2_155 EVAGYLAS-HGAGHVVLTSRREPGDDARRRLDGLREQYACDVRVITADVA Mvan_1003|M.vanbaalenii_PYR-1 EVAEFLAS-HGAGHLVLTGRRSASDTVRQRIDAMRERFDCQVLVATADVA Mb2074c|M.bovis_AF2122/97 AVARHVVARHGVRNLVLVSRRGPDAPGAAELVAELAAAGAQVQVVACDAA Rv2048c|M.tuberculosis_H37Rv AVARHVVARHGVRNLVLVSRRGPDAPGAAELVAELAAAGAQVQVVACDAA MUL_2266|M.ulcerans_Agy99 ALARHLVAHHGVAHLVLISRRGPAAPGATELVAELSAAGAQVEVVACDAA MAV_2450|M.avium_104 TLARHLVTGHGVRDLALLSRTGPDAPGAAEFVAELEAAGARVQVIACDAA MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MMAR_1180|M.marinum_M -------------------------------------------------- TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK DAHAVARLLATVQAEMPPLAGIVHAAGEIGTTPLADLDDAEVDRVFAGKV MAB_0939|M.abscessus_ATCC_1997 DGHDVARLLAGIQAELPPLAGIVHAAGEIGTTPLSDLEDAEVDRVFAGKV MSMEG_0408|M.smegmatis_MC2_155 DAHDVARLMTTVAAELPPLAGIVHAAGEIGTTPLSGLDDAEVDRVFAGKV Mvan_1003|M.vanbaalenii_PYR-1 DRDDVARLFSTMRSELPPLAGIVHAAGEIGTSPLRTLDDAEMDRVFAGKV Mb2074c|M.bovis_AF2122/97 DRAALAKVIADIPVQHP-LSGVIHTAGALDDAVVMSLTPDRVDVVLRSKV Rv2048c|M.tuberculosis_H37Rv DRAALAKVIADIPVQHP-LSGVIHTAGALDDAVVMSLTPDRVDVVLRSKV MUL_2266|M.ulcerans_Agy99 DRPALAKVIAENPAQRP-LSAVVHAGGVLDDAVISSLTPERVDTVLRAKV MAV_2450|M.avium_104 DRAALAGVIAGISAERP-LSGVIHAAGVLDDAMITSLTPERIDAVLRAKV MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MMAR_1180|M.marinum_M ----HEATMHRMGVVRRDVIAAISKTHGLNVADLVLVPPGSIPLTTSGKV TH_4458|M.thermoresistible__bu ----EVDTDELIAAIR----TAVTSQHDIGVHTVVLVDPLRIPTTSSGKI Mflv_0405|M.gilvum_PYR-GCK WGAWHLSEATSDLQ--LDFFISTSSIASVWGGFGQAAYGAANAFLDGLAW MAB_0939|M.abscessus_ATCC_1997 WGAWHLSEAAAGLK--LDFFINTSSIAAVWGGYGQTAYSAANAFLDGLAW MSMEG_0408|M.smegmatis_MC2_155 WGAWHLSEALTDLRTDLDFFVSTSSIASVWGGFGQTAYGAANAFLDGLAW Mvan_1003|M.vanbaalenii_PYR-1 WGAVYLCEEVADMG--LDFFLATSSIASVWGSHGQTAYGAANAFLDGLAD Mb2074c|M.bovis_AF2122/97 DAAWHLHELTRDLD--VSAFVMFSSMAGLVGSSGQANYAAANSFLDALAA Rv2048c|M.tuberculosis_H37Rv DAAWHLHELTRDLD--VSAFVMFSSMAGLVGSSGQANYAAANSFLDALAA MUL_2266|M.ulcerans_Agy99 DAAWNLHELTRDLD--LSAFVMFSSMAGVVGSSGQANYAAANTFVDGLAA MAV_2450|M.avium_104 DAAWNLHELTRDMN--LSAFVMFSSMAGLVGSSGQGNYAAANSFLDALAA MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MMAR_1180|M.marinum_M R-------------------------------RRECLQRYLHDEFTRLDG TH_4458|M.thermoresistible__bu R-------------------------------RRTCRQRFLDGELDAFAE Mflv_0405|M.gilvum_PYR-GCK RLREQGVAGVSVNFGPWSAGMADAQSRARLEQRGIKTLSPADALAGLSDA MAB_0939|M.abscessus_ATCC_1997 RLREQGIAGTSVNFGPWSAGMADAESRARLEQRGIKTLSPTDALAGLADV MSMEG_0408|M.smegmatis_MC2_155 RLRERGVTAVSVNFGPWAAGMADAESRARLEQRGVRTLSPAEALAGMADV Mvan_1003|M.vanbaalenii_PYR-1 SLRARGIPGISVNFGPWAAGMADAKAREQLSRRGVKTLAPADALAGMADV Mb2074c|M.bovis_AF2122/97 HRRAHGLPAISLGWGLWDQASAMTSGLDAADLARLGREGVLALSTAEALE Rv2048c|M.tuberculosis_H37Rv HRRAHGLPAISLGWGLWDQASAMTGGLDAADLARLGREGVLALSTAEALE MUL_2266|M.ulcerans_Agy99 HRRAHGLPAISLGWGLWDQASDMTGGMDAADRARLGREGVLALSSDEAME MAV_2450|M.avium_104 HRRAHGLPAISLAWGLWDQASAMTGGLDAADLARLGRDGILALSSDEAME MLBr_00135|M.leprae_Br4923 ----------------------MTASVEGADQK----------------- MMAR_1180|M.marinum_M QLREPGPRVADAAAADADAGADSGLVQR---------------------- TH_4458|M.thermoresistible__bu WRLATPRPAQPVPAADEQADEQAGAGPG---------------------- Mflv_0405|M.gilvum_PYR-GCK VISAAP---HPVVARVDWSRFLPLYQQAGRRGFLAELERELPAAPAQQGP MAB_0939|M.abscessus_ATCC_1997 VAASGSNAVQGVIARIDWARFLPLYQQAGKRGFLAELDREVPSHLA--GV MSMEG_0408|M.smegmatis_MC2_155 VAGPVQ----GVVAKIDWSRFLPLYQQAGRRAFLSELESELPAAATGAAA Mvan_1003|M.vanbaalenii_PYR-1 IAASTA---HAVVARIDWATFLPVYQLQRRRAFLSQLEREVPDVPD--AS Mb2074c|M.bovis_AF2122/97 LFDTAMIVDEPFLAPARIDLTALRAHAVAVPPMFSDLASAPTRRQVDDSV Rv2048c|M.tuberculosis_H37Rv LFDTAMIVDEPFLAPARIDLTALRAHAVAVPPMFSDLASAPTRRQVDDSV MUL_2266|M.ulcerans_Agy99 LFDTALIVNQAFLAPARIDLAALRAHAVAVPPMFSDLVSAPTRRQIDAAL MAV_2450|M.avium_104 LFDTALIVDEPFLAPARIDLGALRAHAVAVPPMFADLVNAPTRRRVDDSL MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MMAR_1180|M.marinum_M -------------------------------------------------- TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK AVTASGRTPLVERLTTAPLQQRKRLLTDYLRDAVAEVTRVDAAEIREDAG MAB_0939|M.abscessus_ATCC_1997 AGAQSGSTQLVERLANAPVQQRKKLLTDYLRDAVAEVTRVDVSEIREDAG MSMEG_0408|M.smegmatis_MC2_155 PATVPGKPPLVEQLTKAPVQQRKSLITNYLRNAVAEVTRVDADEIRDEAG Mvan_1003|M.vanbaalenii_PYR-1 APAPSGTTRFVEELTLAPVEQRRKLVLEYLRAAVAEVTRVDAAEIRDEAG Mb2074c|M.bovis_AF2122/97 AAAKSKSALAHRLHGLPEAEQHAVLLGLVRLHIATVLGNITPEAIDPDKA Rv2048c|M.tuberculosis_H37Rv AAAKSKSALAHRLHGLPEAEQHAVLLGLVRLHIATVLGNITPEAIDPDKA MUL_2266|M.ulcerans_Agy99 ATAKSKSALAHRLHGLPELEQHAVVLDLVRSHIATVLGTITPEAIDPDKA MAV_2450|M.avium_104 AAAKSKSALAHRLDGLPEAEQHAVLLELVRSHIATVLGSPTAEAIDPDKA MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MMAR_1180|M.marinum_M -------------LRLLRHQQHDLLVGVVCAQAATVLDYPSPNDIDPEWA TH_4458|M.thermoresistible__bu -------------AGPGADEIRAWFVAQLAGELG-----LSPDDIDTGQP Mflv_0405|M.gilvum_PYR-GCK FFDLGMDSLMAVELRRRIETGVGKEIPVTLVMDHPRLSDAADYLLGDVLG MAB_0939|M.abscessus_ATCC_1997 FFDLGMDSLMAVELRRRMEQGVGKEIPVTLVMDHPRISDVADYLLGDVLG MSMEG_0408|M.smegmatis_MC2_155 FFDLGMDSLMAVELRRRIEQGVGKDIPVTLVMDHPRLSDAADYLLVEVLG Mvan_1003|M.vanbaalenii_PYR-1 FFDLGMDSLMAIELRRRLEQGLGKELPVTLAMDHPHLSDAAEYVLGDVLG Mb2074c|M.bovis_AF2122/97 FQDLGFDSLTAVEMRNRLKSATGLSLSPTLIFDYPTPNRLASYIRTELAG Rv2048c|M.tuberculosis_H37Rv FQDLGFDSLTAVEMRNRLKSATGLSLSPTLIFDYPTPNRLASYIRTELAG MUL_2266|M.ulcerans_Agy99 FQELGFDSLTAVEMRNRIKTVTGLSLSPTLIFDYPTPNGLANYIRAELAG MAV_2450|M.avium_104 FQELGFDSLTAVEMRNRLKTATGLALSPTLIFDYPTPNALAGYIRTELAG MLBr_00135|M.leprae_Br4923 ------------------------------------SEKLISYLKKVVVE MMAR_1180|M.marinum_M FQDLGFDSVKATELLDRLQTVTELTLPPTLAFDYPTPAALATHLGQLLSG TH_4458|M.thermoresistible__bu FAYYGLDSVRAIQLMTALEAWSGIKVAPTLAYDHPTIDLAAEHLAGLTHT :: Mflv_0405|M.gilvum_PYR-GCK LTEAAT-APKAATVVSTAA--------DEPIAIVAVSCRFPG-APNPEAF MAB_0939|M.abscessus_ATCC_1997 LAEQAKPAAQLASAVTGRT--------DEPIAIVAVSCRFPG-APDPEAF MSMEG_0408|M.smegmatis_MC2_155 LGEQTN--VRQASTVTART--------DDPIAVVAVSCRFPG-APDPESF Mvan_1003|M.vanbaalenii_PYR-1 LSEHTV--AQPDTPSTVRT--------DDPIAIVGMACRFPG-ADDTDAF Mb2074c|M.bovis_AF2122/97 LPQEIK----HTPAVRTTS--------EDPIAIVGMACRYPGGVNSPDDM Rv2048c|M.tuberculosis_H37Rv LPQEIK----HTPAVRTTS--------EDPIAIVGMACRYPGGVNSPDDM MUL_2266|M.ulcerans_Agy99 APQEVK----HTPAVRVTG--------DDPIAIVGMSCRYPGGIESPDDL MAV_2450|M.avium_104 APQETT----HAPVVRATD--------DDPIAIVGMSCRFPGGVDSPEAL MLBr_00135|M.leprae_Br4923 LDETRA----RLREYEQRA--------TEPVAVVGIGCRFPGGVDSPDRL MMAR_1180|M.marinum_M SVAVAAPVQPRVST-------------DEPVAVVGMACRFPGGVDSAAAL TH_4458|M.thermoresistible__bu ATSTAADAGVSTGAGRRPEHGPAPDRADEPIAIIGIGCRFPG-ADGPAAY :*:*::.:.**:** .. Mflv_0405|M.gilvum_PYR-GCK WDLLSGGVDAIREVPEDR-FDIDEFYDPDPDAAGKTYTRYGGFLDHIDEF MAB_0939|M.abscessus_ATCC_1997 WDVLSGGVDAIREVPEDR-FDIDEFYDPDPEVAGKTYTRFGGFLDGIDGF MSMEG_0408|M.smegmatis_MC2_155 WELLAGGVDAIREVPEDR-WDIDEFYDPDPDTPGKTYTRFGGFLDGIDGF Mvan_1003|M.vanbaalenii_PYR-1 WSVLAEGADLIREIPDDR-FDINEFYDPDPEAAGKIYSRYGGFLDGVDGF Mb2074c|M.bovis_AF2122/97 WDMLIQGRDVLSEFPADRGWDLAGLYNPDPDAAGACYTRTGGFVDGVGDF Rv2048c|M.tuberculosis_H37Rv WDMLIQGRDVLSEFPADRGWDLAGLYNPDPDAAGACYTRTGGFVDGVGDF MUL_2266|M.ulcerans_Agy99 WDMLMARRDVLSDFPADRGWDLAGLFNPDPDVPGACYTRTGGFVDRVGDF MAV_2450|M.avium_104 WQMVAEGRDVLSEFPTDRGWDLAGVYNPDPDVPGTCYTRTGGFVDNVADF MLBr_00135|M.leprae_Br4923 WDVVSECRDVVSEFPTDRGWDVDGLFDPDPDAEGKTYTRWGAFLDDAAGF MMAR_1180|M.marinum_M WDLVAGGTEAVGEFPADRGWNLAELFDPDPDAVGKTYARAGSFVADVAGF TH_4458|M.thermoresistible__bu WRLLREGRDAITATPPER---------WDTDSVGDG-TRWGGFLERIDGF * :: : : * :* *.: * :* *.*: * Mflv_0405|M.gilvum_PYR-GCK DPEFFGLSPREAVWIEPQQRLMLETVWEGLERAGYAPSALRGSRTGVFVG MAB_0939|M.abscessus_ATCC_1997 DPEFFGISPREAVWIEPQQRLMLETVWEGLERAGYSPAALRGSRTGIFAG MSMEG_0408|M.smegmatis_MC2_155 DPEFFGISPREAVWIEPQQRLMLETVWEGLERAGYAPSDLRGSRTGVFTG Mvan_1003|M.vanbaalenii_PYR-1 DPEFFGISPREAVWIDPQQRLVLETAWEGLERAGYSAAALRGSRSGVYVG Mb2074c|M.bovis_AF2122/97 DPAFFGVGPSEALAMDPQQRMLLELSWEALERAGIDPTGLRGSATGVFAG Rv2048c|M.tuberculosis_H37Rv DPAFFGVGPSEALAMDPQHRMLLELSWEALERAGIDPTGLRGSATGVFAG MUL_2266|M.ulcerans_Agy99 EPAFFGVGPSEALAMDPQQRMFLELSWEALERAGIEPGGLRGSATGVFAG MAV_2450|M.avium_104 DPAFFGIAPSEALAMDPQQRMFLELSWEALERAGIDPVKLRGSATGMFAG MLBr_00135|M.leprae_Br4923 DAGFFGIAPSEVLAMDPQQRLMLEVSWEALEYAGIDPLSLRGSATGVFTG MMAR_1180|M.marinum_M DAEFFGISAREAQTMDPQQRLLLEVCWEALETAQIDPAALLRSKTGVFVG TH_4458|M.thermoresistible__bu DAGFFGISPREAVRIDPQQRLLLEVAWEALEDAGLVPDRLAGSRTGVFTG :. ***:.. *. ::**:*:.** **.** * . * * :*::.* Mflv_0405|M.gilvum_PYR-GCK VAANEYAHLLSAESIDKIEPHFITGNALNAISGRVAFALGLEGPAVAVDT MAB_0939|M.abscessus_ATCC_1997 VGANEYAHLLSSESIDKIEPYFITGNALNAISGRVAFALGFEGPAVAVDT MSMEG_0408|M.smegmatis_MC2_155 VAANEYAHLLSAESIDKIEPHFITGNALNAISGRVAFALGFEGPAVAVDT Mvan_1003|M.vanbaalenii_PYR-1 VGANEYSHLLSGGSLDGIEAQFITGNALNVIAGRVSFTLGLEGPAVAVDT Mb2074c|M.bovis_AF2122/97 VMTQGYGMFA----AEPVEGFRLTGQLSSVASGRVAYVLGLEGPAVSVDT Rv2048c|M.tuberculosis_H37Rv VMTQGYGMFA----AEPVEGFRLTGQLSSVASGRVAYVLGLEGPAVSVDT MUL_2266|M.ulcerans_Agy99 VMTQGYGMFA----AEPVEGFRLTGQLSSVASGRVAYVLGLEGPAVSVDT MAV_2450|M.avium_104 VYTQGYGMGA----APIAEGFRLTGQSSSVASGRVSYVLGLEGPAVSVDT MLBr_00135|M.leprae_Br4923 IFAPSYGSRD----TGGLQGYGLTGTAVSVASGRVSYVLGLEGPAVSVDT MMAR_1180|M.marinum_M AWSQQYG-----GGSEGAEGYGLTGLSTSVASGRVAYALGLQGPAITIDT TH_4458|M.thermoresistible__bu VSTYDYLHLQL-SHPELIDAYSGTGTASSIAANRLSYVFDFRGPSLTLDS : * : ** . :.*:::.:.:.**::::*: Mflv_0405|M.gilvum_PYR-GCK ACSSSLVAVHQATQALRSGDCDMALAGGVNVLLSPVTVVAASRARMLSPV MAB_0939|M.abscessus_ATCC_1997 ACSSALVAVHQAVQALHSGDCDLALAGGVNVLLSPVTVIAASRARMLSPV MSMEG_0408|M.smegmatis_MC2_155 ACSSALVAVHQACQALQSGDCDLALAGGVNVLLSPVTVVAASRARMLSPV Mvan_1003|M.vanbaalenii_PYR-1 ACSSSLVAVHQACQGLQSGDCDLALAGGVNVLLSPATTIATSRARMLSPD Mb2074c|M.bovis_AF2122/97 ACSSSLVALHMAVGSLRSGECDLALAGGVTVNATPDIFVEFSRWRGLSPD Rv2048c|M.tuberculosis_H37Rv ACSSSLVALHMAVGSLRSGECDLALAGGVTVNATPDIFVEFSRWRGLSPD MUL_2266|M.ulcerans_Agy99 ACSSSLVALHMAVQSLRSGECDLALAGGVTINATPDIFVEFSRWRGLSAD MAV_2450|M.avium_104 ACSSSLVALHMAVQSLRSGECDLALAGGVTVNATPDIFVEFSRMRGLSVD MLBr_00135|M.leprae_Br4923 ACSSSLVAIHWAMSSLRSGECDLALAGGVTVMGLPSIFVGFSRQRGLAAD MMAR_1180|M.marinum_M ACSSSLVAAHLACQSLHTGESTLALAGGVTVMTTPAVFTEFARQRGLAAD TH_4458|M.thermoresistible__bu ACSSSLVAVHQACRSLRDGECDLALAGGVNIMLSAGIGLNFTRAGVMATD ****:*** * * .*: *:. :******.: . :* :: Mflv_0405|M.gilvum_PYR-GCK GRCKTFDASADGYVRSEGCGILVLKRLSDAVRDGDRVCAVIAGSAVNQDG MAB_0939|M.abscessus_ATCC_1997 GRCKTFDASADGYVRSEGCGILVLKRLSDAERDGDRVLAVIPGSAVNQDG MSMEG_0408|M.smegmatis_MC2_155 GRCKTFDASADGYVRSEGCGVLVLKRLSDAVRDGDRVCAVIPASSVNQDG Mvan_1003|M.vanbaalenii_PYR-1 GRCKTFDAAADGYVRGEGCGILVLKRLSDAVRDGDRIQAVIRGSAVNQDG Mb2074c|M.bovis_AF2122/97 GRCKAFAAAADGTGFSEGGGMLVLQRLSDARRLGHPVLAVVVGSAVNQDG Rv2048c|M.tuberculosis_H37Rv GRCKAFAAAADGTGFSEGGGMLVLQRLSDARRLGHPVLAVVVGSAVNQDG MUL_2266|M.ulcerans_Agy99 GRCKAFAGAADGTGFSEGGGMLVVERLSDAQRLGHPVLALVRGSAVNQDG MAV_2450|M.avium_104 GRCKAYAGAADGTGFSEGGGMLVVERLSDARRLGHPVLAVVRGSAVNQDG MLBr_00135|M.leprae_Br4923 GRCKAFARAADGTGWGEGAGVVVLERLSDAQRLGHTVLAVVRGSAVNQDG MMAR_1180|M.marinum_M GRCKAFSAAADGTGWGEGAAVLVLERLSDANRNGHPVLAVIAGSAINQDG TH_4458|M.thermoresistible__bu GRCKTFDARADGWVRGEGAGIVVLKPLREALADEDPIYAVIRGSAVNQDG ****:: *** .** .::*:: * :* . : *:: .*::**** Mflv_0405|M.gilvum_PYR-GCK ASSGLTVPNGGAQQRLIGTVLARAGITGGEVDYLEAHGTGTPLGDPIEVQ MAB_0939|M.abscessus_ATCC_1997 ASSGLTVPNGGAQQRLIGSVLARAGLVGGDVDYLEAHGTGTPLGDPIEVQ MSMEG_0408|M.smegmatis_MC2_155 ASSGLTVPNGGAQQRLIEATLARAGLSGADVDYLEAHGTGTPLGDPIEVQ Mvan_1003|M.vanbaalenii_PYR-1 ASGGLTVPNGGAQQRVIAAALTRAGLSGSDIDYLEAHGTGTSLGDPIEVQ Mb2074c|M.bovis_AF2122/97 ASNGLTAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQ Rv2048c|M.tuberculosis_H37Rv ASNGLTAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQ MUL_2266|M.ulcerans_Agy99 ASNGLTAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQ MAV_2450|M.avium_104 ASNGLTAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQ MLBr_00135|M.leprae_Br4923 ASNGLTAPNGLAQQRVIQAALTNAGLSSADVDVVEAHGTATTLGDPIEAQ MMAR_1180|M.marinum_M ASNGLTAPSGPAQQRVITQAVANAGVGLDEVDAVEAHGTGTTLGDPIEAG TH_4458|M.thermoresistible__bu RTNGLMAPSRTAQEVVLTDAYRRAGVSPGVVQYVEAQGIGTPVGDAIEVG :.** .*. :*: :: . .**: :: :*.:* .*.:**.**. Mflv_0405|M.gilvum_PYR-GCK AAAAAYAGARDAD----RPLLMGSVKTNIGHTESASGAAGLIKVVLSLQH MAB_0939|M.abscessus_ATCC_1997 AAAAAYGGSRDAD----RPLLMGSVKSNIGHTESASGAAGLIKVVLSLQN MSMEG_0408|M.smegmatis_MC2_155 AAAAAYGAGRDAD----RPLLMGSVKTNIGHTESASGAAGLIKVVLSLQH Mvan_1003|M.vanbaalenii_PYR-1 AAGAVLGAGRDPD----RPLLMGSVKTNVGHLESASGVAGLIKVVLSLQH Mb2074c|M.bovis_AF2122/97 ALLATYGQDRGEP---GEPLWLGSVKSNMGHTQAAAGVAGVIKMVLAMRH Rv2048c|M.tuberculosis_H37Rv ALLATYGQDRGEP---GEPLWLGSVKSNMGHTQAAAGVAGVIKMVLAMRH MUL_2266|M.ulcerans_Agy99 ALLATYGQDRGSAGAAGKALWLGSIKSNMGHTQAAAGVAGVIKMVQAMRH MAV_2450|M.avium_104 ALLATYGQDRGQP------LWLGSIKSNMGHTQAAAGVAGVIKMVLAMRH MLBr_00135|M.leprae_Br4923 ALLATYGQGRPAD----QPLWVGSIKSNMGHTQAAAGVAGVIKMVQAMRH MMAR_1180|M.marinum_M ALIATYGAAHHPD----HPLWLGSIKSNIGHTQAAAGVAGLIKMIAALNH TH_4458|M.thermoresistible__bu ALGTVLAEDRPPD----SPCLIGSVKTNIGHLEAAAGIAGLIKVALALRH * :. . : :**:*:*:** ::*:* **:**: ::.: Mflv_0405|M.gilvum_PYR-GCK ETLPQSLHFDTPSPHIPWDSLPVRVVDTAMPWQ---PNGRPRRAGVSSFG MAB_0939|M.abscessus_ATCC_1997 GVLPQSLHFDNPSPHIPWESLPVRVVDKAIPWQ---ANGRPRRAGVSSFG MSMEG_0408|M.smegmatis_MC2_155 GVLPQSLHFENPSPHIPWDALPVRVIDEPVPWQ---TNGRVRRAGVSSFG Mvan_1003|M.vanbaalenii_PYR-1 EMLPRHLHFKTPSPHIPWDRLAVRVVAEPTPWR---ADGRPRRAGVSSFG Mb2074c|M.bovis_AF2122/97 ELLPATLHVDVPSPHVDWSAGAVELLTAPRVWP---AGARTRRAGVSSFG Rv2048c|M.tuberculosis_H37Rv ELLPATLHVDVPSPHVDWSAGAVELLTAPRVWP---AGARTRRAGVSSFG MUL_2266|M.ulcerans_Agy99 EVLPATLHVDVPSPHVDWSAGAVELLTEAQPWPAESAGDRVRRAGVSSFG MAV_2450|M.avium_104 ELLPATLHVDEPSPHVDWSAGAVSLLTEAQPWP----GERPRRAGVSSFG MLBr_00135|M.leprae_Br4923 HVMPATLHVDEPSPRVDWTTGAVSVLTEARDWS---VEGRPRRAGVSSFG MMAR_1180|M.marinum_M DSLPPTLNVDRPSPHVDWSAGTVRVLTEPVPWP---VTDHPRTAAVSSFG TH_4458|M.thermoresistible__bu RMIPPTLNFTEPNPTIEFDKLPVRVAQTLTPWP---DDSGRAVAGVSAFG :* *:. *.* : : .* : * *.**:** Mflv_0405|M.gilvum_PYR-GCK FTGTNAHVLIEEAPTDLAGPTEPTAPAEPVDEDAAADPAPAPVEVLPLSA MAB_0939|M.abscessus_ATCC_1997 FTGTNAHVLIEEAPQPQATP----------DEDDASTPQSAPVSVLPLSA MSMEG_0408|M.smegmatis_MC2_155 FTGTNAHVLVEEAPPQLHTADAAP----VEPAATAEAGTDDSPQVLALSA Mvan_1003|M.vanbaalenii_PYR-1 FSGTNAHVVLEEPPAQSADLRQPPTDGKDGAAGLESATAPEPAGVLPISA Mb2074c|M.bovis_AF2122/97 ISGTNAHVIIEAVP---------------VVPRR-EAGWAGPVVPWVVSA Rv2048c|M.tuberculosis_H37Rv ISGTNAHVIIEAVP---------------VVPRR-EAGWAGPVVPWVVSA MUL_2266|M.ulcerans_Agy99 ISGTNAHVIVEAAP---------------RVEVGGSSGGAVPVVPWVVSA MAV_2450|M.avium_104 ISGTNAHVIIEAVP---------------AVEPAHADAPALPVLPWVVSA MLBr_00135|M.leprae_Br4923 ISGTNAHVILEEAPTP------------VEASYSTADQQRLSVVPWVVSG MMAR_1180|M.marinum_M ISGTNAHLILQQAPTPSSGS--------PEPAGRPQHGAELGLPMWPVSA TH_4458|M.thermoresistible__bu FGGTNAHVVLAEAPQVR-------------AAATADDHADGFVEILPLSA : *****::: * :*. Mflv_0405|M.gilvum_PYR-GCK RSPEALVALAQRYETWLTAHPEADLADVCRTAGTGRSHFEHRAALVV--- MAB_0939|M.abscessus_ATCC_1997 RSPEALAAVAQRYESWLAAHPDVDLEDVCLTAGRGRSHFEHRAALVV--- MSMEG_0408|M.smegmatis_MC2_155 RSPEALVELARRYDDWLSATPGLDIADVCHTAGVGRSHFEYRAALVV--- Mvan_1003|M.vanbaalenii_PYR-1 RSPEALTALARRYESWLTAHPDADIADVCYTAGAGRSHFEHRAALVV--- Mb2074c|M.bovis_AF2122/97 KSESALRGQAARLAAYVRGDDGLDVADVGWSLAG-RSVFEHRAVVVG--- Rv2048c|M.tuberculosis_H37Rv KSESALRGQAARLAAYVRGDDGLDVADVGWSLAG-RSVFEHRAVVVG--- MUL_2266|M.ulcerans_Agy99 KSGSALGAQAARLAAHVRSHDELDVADVGWSLAG-RSTFEHRAVVLG--- MAV_2450|M.avium_104 KSAAALRAQAARLAEYVRAQGELDIADVGWTLAG-RATFEHRAVVVG--- MLBr_00135|M.leprae_Br4923 RSTAALMAQASRLAFYVQADPEVDPVDVGCALAA-RSVFEHRAVVVG--- MMAR_1180|M.marinum_M RTPAGLAAQAERLHQHLLRHRDLDLTDVGYSLGCTRTHHPHRAVVTVPAA TH_4458|M.thermoresistible__bu RSQAALDALAERYESALTGG--VPPADLCHTAGARRAHHDHRLAVVG--- :: .* * * : *: : . *: . :* .: Mflv_0405|M.gilvum_PYR-GCK --DSVESARIALTDLAQNRLR-PGVVRG-EHLNHPTTAWMFTGQGSQYPG MAB_0939|M.abscessus_ATCC_1997 --DSIQTAREGLLELAQNRLR-PGVVRG-EHTNHPTTAWLFTGQGSQYPG MSMEG_0408|M.smegmatis_MC2_155 --DSVERAREGLAALAEGRTP-AGVVRG-EHVHRPTTAWLFTGQGSQYPG Mvan_1003|M.vanbaalenii_PYR-1 --DSVDGARDLLAGLAEDRLG-PGAVRG-VCGDPPKTAWLFTGQGSQYPG Mb2074c|M.bovis_AF2122/97 --GDRDRLLAGLDELAGDQLG-GSVVRG-TATAAGKTVFVFPGQGSQWLG Rv2048c|M.tuberculosis_H37Rv --GDRDRLLAGLDELAGDQLG-GSVVRG-TATAAGKTVFVFPGQGSQWLG MUL_2266|M.ulcerans_Agy99 --ADRDGLLAGLDELAGDEFGGASVIRG-VAGAAGKTVFVFPGQGSQLLG MAV_2450|M.avium_104 --GDRDRLLAGLDELAADDPA-ASIIRG-VATPAGKTVFVFPGQGSQTLG MLBr_00135|M.leprae_Br4923 --ESREQLIAGLAGLAVGESG-AGVAIG-QAAPLGKTVVVFPGQGAQRIG MMAR_1180|M.marinum_M SPDPRAELLAALQALAAGDPHPQLVQHHLRSTSAGKTVFVFPGQGGQYPG TH_4458|M.thermoresistible__bu --ASRAELIGALAAYRRGEPHPGVFTGRSQSGHRSGVVFVFSDEGSQWRG * . .. :*..:*.* * Mflv_0405|M.gilvum_PYR-GCK MARELFDTEPVFADTVTRCADAVADLLPRPLLDVMFAGGREAGVPPTETL MAB_0939|M.abscessus_ATCC_1997 MARELFDAEPVFAETVTRCAEAVKDIVTRPLLEVMFATDRETGGKAGEAL MSMEG_0408|M.smegmatis_MC2_155 MARELFDTQPVFAQTVRQCAEAVADMLPRPLLDVLFATDRET----ADLL Mvan_1003|M.vanbaalenii_PYR-1 MARELFDTEPVFRDTVTRCAEAIGDTLPRPLLEVLFDTDGDN----GQTL Mb2074c|M.bovis_AF2122/97 MGMGLHAGYPVFAEAFNTVVGELDRHLLRPLREVMWGH-------DENLL Rv2048c|M.tuberculosis_H37Rv MGMGLHAGYPVFAEAFNTVVGELDRHLLRPLREVMWGH-------DENLL MUL_2266|M.ulcerans_Agy99 MGMGLHAGYPVFAEAFNTVVGELDRHLLRPLREVIWGH-------DENLL MAV_2450|M.avium_104 MGRQLHAGYPVFAEAFDAVVAELDRHLLRPLRDVIWGD-------DENVL MLBr_00135|M.leprae_Br4923 MGRELCSQLPVFAEEFDAVTGELDRHMRLPLRDVVWGA-------DAGLL MMAR_1180|M.marinum_M MAAELYRRHQVFSRALDECDQALFGWTGWSVGAVVRGEP------SAMAL TH_4458|M.thermoresistible__bu MAQRLYAEDQVFRTALAECDRALRRHMEISPLSELLADP------SHSRM *. * ** . : . : : Mflv_0405|M.gilvum_PYR-GCK RHTSFAQPALFAVEMGLARLWQSWGIVPDVVLGHSVGQYAAACVAGVFSL MAB_0939|M.abscessus_ATCC_1997 RHTSFAQPALFAVEMGLARLWQSWGIEPDVVLGHSVGQYAAACVAGVFSI MSMEG_0408|M.smegmatis_MC2_155 QHTSFAQPALFAVEMGLARLWQSWAIEPDVVLGHSVGQYAAACVAGVFSL Mvan_1003|M.vanbaalenii_PYR-1 RHTSYAQPALFAIEMGLARLWQARGIEPDVVLGHSVGQYAAACVAGVFGL Mb2074c|M.bovis_AF2122/97 NSTEFAQPALFAVEVALFRLLGSWGVRPDFVMGHSIGELSAAHVAGVLSL Rv2048c|M.tuberculosis_H37Rv NSTEFAQPALFAVEVALFRLLGSWGVRPDFVMGHSIGELSAAHVAGVLSL MUL_2266|M.ulcerans_Agy99 NTTEFAQPALFAVEVALYRLLESWGVRPDFVMGHSVGELSAAHVAGVLSL MAV_2450|M.avium_104 NSTEFAQPALFAVEVALFRLLESWGVRPDFVMGHSIGELSAAHVAGVLSL MLBr_00135|M.leprae_Br4923 DSTEFAQPALFAVEVALFAVLQHWGLQPDFVMGHSIGELAAAYVAGVLAP MMAR_1180|M.marinum_M QRVDVVQPVLFAVMVSLARTLISYGIEPDAVIGHSQGEIAAAYVAGVFTL TH_4458|M.thermoresistible__bu DEVTIASPALFAVQVALAALWQSWGVEPAAVIGHRMGEVAAAHVAGVLGL . ..*.***: :.* .: * *:** *: :** ****: Mflv_0405|M.gilvum_PYR-GCK EDGARLMAERGRLFGSLPEGGRMVAVFADAKRVEQVAADF-PRVSVGAYN MAB_0939|M.abscessus_ATCC_1997 EDGARLIAERGRLFGGLPAGGRMVAVFSDAKHVEQIAGEF-PRVSVGAYN MSMEG_0408|M.smegmatis_MC2_155 DDGARLMAERGRMFGSLPEGGRMVAVFADAEHVEQVAGEF-PRVSVGAYN Mvan_1003|M.vanbaalenii_PYR-1 EDGARLVADRGRLFGGLPVGGRMVAVFTDAEVVEDFADEF-PQVSVAAYN Mb2074c|M.bovis_AF2122/97 ENAAVLVAARGRLMQALPAGGAMVAVQAAEEEVRPLLS---AEVDIAAVN Rv2048c|M.tuberculosis_H37Rv ENAAVLVAARGRLMQALPAGGAMVAVQAAEEEVRPLLS---AEVDIAAVN MUL_2266|M.ulcerans_Agy99 ENAAVLVAARGRLMQALPDGGAMIAVQATEQEVLPLLG---AQVSIATIN MAV_2450|M.avium_104 QNAAVLVAARGRFMQALPEGGAMIAVQATEAQVRPLLG---PDVGIAAVN MLBr_00135|M.leprae_Br4923 ADAAMLVVARGRLMQSMPAGGTMWAVAASEDEVVSLLG---EGVGIAAIN MMAR_1180|M.marinum_M EQAAKIVALRSAALADLSGTGGMASVLLGADEVAARLQPYGDALTVAAVN TH_4458|M.thermoresistible__bu DDAAALLCGR-TRLSRLASTG----------------------------- :.* :: * : :. * Mflv_0405|M.gilvum_PYR-GCK GPN-TVLSGPGEDLEQIVGTFGEDGIRCTWLETSHAFHSELLDPVLDEFE MAB_0939|M.abscessus_ATCC_1997 GPN-TVLSGPGEDLEQAVARFQEEGIRCTWLETSHAFHSELLDPILDEFE MSMEG_0408|M.smegmatis_MC2_155 GPN-TVLSGPGEDLEEIVERFEDEGIRCTWLATSHAFHSELLDPVLDEFE Mvan_1003|M.vanbaalenii_PYR-1 GPN-TVLAGPASDLEQIVAGCSGEGIRTTWLDTSHAFHSALLDPVLDEFE Mb2074c|M.bovis_AF2122/97 GPASLVISGAQNAVAAVADQLRADGRRVHQLAVSHAFHSPLMDPMIDEFA Rv2048c|M.tuberculosis_H37Rv GPASLVISGAQNAVAAVADQLRADGRRVHQLAVSHAFHSPLMDPMIDEFA MUL_2266|M.ulcerans_Agy99 GPASVVISGAQDAVSAVAEQLRADGRRVHRLAVSHAFHSPLMDPMIDEFA MAV_2450|M.avium_104 GPAAVVISGDHDAAVAIAERLRAEGHRVHRLSVSHAFHSPLMEPMIDEFG MLBr_00135|M.leprae_Br4923 APESVVISGPQAAVSAIADKFAAQGRRVHQLAVSHAFHSPLMEPMLEEFV MMAR_1180|M.marinum_M GPTHTIISGDPPAIEAFVAAGEADGIQIRSITVDYASHCGQVEPARERLL TH_4458|M.thermoresistible__bu -------------------------------------------AVREGLD . : : Mflv_0405|M.gilvum_PYR-GCK SYAAQLQFAAPTLPLVCNRTGAVLTGQ---TSLDAQYWRRHSRQPVQFAE MAB_0939|M.abscessus_ATCC_1997 SYAAQVQFAAPTLPLVCNRTGAVLTAQ---TPIDGQYWRRHSRQPVQFAE MSMEG_0408|M.smegmatis_MC2_155 AYAAQFQFAAPTLPLVCNRTGAVLTGQ---TPLDAQYWRRHSRQPVQFAE Mvan_1003|M.vanbaalenii_PYR-1 SCAARLAYAAPTRPLVCNRTGAVVTGP---GVIDAQYWRRHARQPVQFAE Mb2074c|M.bovis_AF2122/97 AVAAGIAIGRPTIGVISNVTG-QLAGD---DFGSAAYWRRHIRQAVRFAD Rv2048c|M.tuberculosis_H37Rv AVAAGIAIGRPTIGVISNVTG-QLAGD---DFGSAAYWRRHIRQAVRFAD MUL_2266|M.ulcerans_Agy99 TVAGELTVNAPTIGIISNLTG-QLAGE---DFGSAAYWKRHVRDAVRFAD MAV_2450|M.avium_104 TVAAGLAIDKPVIPIISNLTG-QPAAD---DFGSPEYWKCHVRDAVRFAD MLBr_00135|M.leprae_Br4923 RVAAQVEVRKPQIGLVSNVTG-ELAGP---DFGSPQYWGEHVSRAVRFVD MMAR_1180|M.marinum_M GELAGLTPAPGRIALYSTVHGVTSDQPLDTTTMTADYWYANLRQPVRFYD TH_4458|M.thermoresistible__bu GLLANLRPDDPRIPLYSTVTGDAVTG----RGFGAAHWMENLHSPVRFSA . . : .. * :* : .*:* Mflv_0405|M.gilvum_PYR-GCK SVRTVAALGCSVLMEIGPQPVLTGAAVQVWPEHLAAPR---AIASLRKGV MAB_0939|M.abscessus_ATCC_1997 SVRTVAALGCSVLMEIGPQPVLTGAAVQVWPEHLAPPR---AIVSLRKGV MSMEG_0408|M.smegmatis_MC2_155 SVRTVAALGCSVLMEIGPQPVLTGAAVQVWPEHMAAPR---AVASLRKGV Mvan_1003|M.vanbaalenii_PYR-1 SVRTLADLGCSVLMEIGPQPFLIAAALRVWPESAATPR---AIPSLRKGP Mb2074c|M.bovis_AF2122/97 SVRFAQAAGGSRFLEVGPSGGLVASIEESLPDVAVT-----TMSALRKDR Rv2048c|M.tuberculosis_H37Rv SVRFAQAAGGSRFLEVGPSGGLVASIEESLPDVAVT-----TMSALRKDR MUL_2266|M.ulcerans_Agy99 SIRFAQSAGAARFLEVGPSIGLTASIEEVLSDAAVTNPV-ATASALRKDR MAV_2450|M.avium_104 SVRFAQSAGATRFLEVGPSSGLTAAIEETLADAPVV-----TVSALRKDR MLBr_00135|M.leprae_Br4923 SARHLQTLGATHFIESGPSSGLMGAIEQSLAPAEAV-----VVSMMGKDR MMAR_1180|M.marinum_M SIKVLLAAAEQVFVEISPHPVLAPAITDTLAASNGQRPGSVVIPTLHRER TH_4458|M.thermoresistible__bu AVRRLLGRGHDAFLEISAHPMLLSAVQEDAADLG---RSCTTLVSMRRGE : : . ::* .. * : . . : : Mflv_0405|M.gilvum_PYR-GCK ADRRQIADALAAAYIGGHKPDFAALHEQ--RGVRLELPTYPFQRRRFWPK MAB_0939|M.abscessus_ATCC_1997 EDRRQIADALASAYVSGHRPNFAALQRH--PRRTVELPTYPFQRRRFWPK MSMEG_0408|M.smegmatis_MC2_155 ADRRQIADALASAYVGGHRPDFAAVHRQ--PRRPVELPTYPFQRRRFWPK Mvan_1003|M.vanbaalenii_PYR-1 DARRQLAEAVAAAYIAGHRLDFTGHDGG--PHRRLPLPTYPFQHRSYWPK Mb2074c|M.bovis_AF2122/97 PEPATLTNAVAQGFVTGMDLDWRAVVG---EAQFVELPTYAFQRRRFWLS Rv2048c|M.tuberculosis_H37Rv PEPATLTNAVAQGFVTGMDLDWRAVVG---EAQFVELPTYAFQRRRFWLS MUL_2266|M.ulcerans_Agy99 PEPVSLVSALAGVFVAGTAVDWRAVVG---QSHFVELPTYAFERRRFWLS MAV_2450|M.avium_104 PEPVALVNAVAQGWVCGMDVDWRGALG---TGHLVDLPTYAFDRRRFWLS MLBr_00135|M.leprae_Br4923 PELASVLGAAGQLFATGMPVEWPAVFAG-SSRRRVTLPTYAFQRRRFWET MMAR_1180|M.marinum_M PDLDALTTTLARLQVHGRGPAWPVVYPH---ARPVPLPTYPFQHHRYWLT TH_4458|M.thermoresistible__bu CGRDVLMTSLAALYASGHAVDWARVHPHG--SHCTAAPTYPWQRQRFWLD : : . * : ***.:::: :* Mflv_0405|M.gilvum_PYR-GCK ---SAGMAIDGRVGASAGSGILGSGKD-LASGDSVYTSRLSVKTQPWLSD MAB_0939|M.abscessus_ATCC_1997 ---SSGTAIEG--GGGLPSGILGRGED-LASGDSVYISRLSVRSQPWLSD MSMEG_0408|M.smegmatis_MC2_155 ---ASSIAVDG---GTAASGILGSGKD-LASGDTIYTSRLSVKSQPWLAD Mvan_1003|M.vanbaalenii_PYR-1 ---TAGIRSDG----SSGSGLLGSAQD-LASGDIVHTSRLSVKTQPWLSD Mb2074c|M.bovis_AF2122/97 -GDGVAADAASLGLAASEHALLGAVIDLPASGGVVLTGRLSPSVQGWLAD Rv2048c|M.tuberculosis_H37Rv -GDGVAADAAGLGLAASEHALLGAVIDLPASGGVVLTGRLSPSVQGWLAD MUL_2266|M.ulcerans_Agy99 -GDAVPADAAGLGLQAGEHALLGAVVELPASGGVVLTGRLSLAAQGWLAD MAV_2450|M.avium_104 -GDGAASDAAGLGLAAGDHALLGAVVELPASGGVLLTGRLSPASQGWLAD MLBr_00135|M.leprae_Br4923 PGTDGTASVSGLGLGSTEHALLGAVVERPDSGGVVLTGRLSLANQPWLAD MMAR_1180|M.marinum_M --TGPGNDAAGLGLDRVGHPLLGAITALADRDEVIATGRLALGVQGWLGA TH_4458|M.thermoresistible__bu --IDRCDTGDGAGTG-----------GTAERTVVPAP------------- . Mflv_0405|M.gilvum_PYR-GCK HVIYGTVVVPGATYAAMALAAVGTP--AHAKDVFFYEPIILPEKSSREVQ MAB_0939|M.abscessus_ATCC_1997 HVIYGTVVVPGATYAAMALAAVGTP--ARAKDVFFYEPIILPEKSSREVQ MSMEG_0408|M.smegmatis_MC2_155 HVIYGTVVVPGATYAAMALAAVGTP--ARLKDVFFYEPIILPEKASREVQ Mvan_1003|M.vanbaalenii_PYR-1 HVIYGTVVVPGATYAAMALAAMPTP--ARVQEVFFYEPIILGDKDSREVQ Mb2074c|M.bovis_AF2122/97 HSVAGVTIFPGAGFVELAIRAGDEVGCGVVDELTLAAPLVLPASGSVAVQ Rv2048c|M.tuberculosis_H37Rv HSVAGVTIFPGAGFVELAIRAGDEVGCGVVDESTLAAPLVLPASGSVAVQ MUL_2266|M.ulcerans_Agy99 HAVGGVVIFPGAGFVELAIRAGDEVGCRVVDELTLAAPLVLPSGGSVAVQ MAV_2450|M.avium_104 HAVGGVVLFPGAGFVELAIRAGDEVGCGIIDELNLAAPLVLPAGGSVAIQ MLBr_00135|M.leprae_Br4923 HVIGGVVLFPGAGFVELVIRAGDEVGCAGVEELVLAAPLVLHPGSGVQVQ MMAR_1180|M.marinum_M HRVGDVVVLPGTAFVDMALAVGDYVGCPAVAELVLHAPLVLAEDTPTDIQ TH_4458|M.thermoresistible__bu ------------------LPAPSASAAPTVDEVLLCA------------- : . : : Mflv_0405|M.gilvum_PYR-GCK LTVHPSVDGE-SKFQVHSR-----------------------PYGERGAE MAB_0939|M.abscessus_ATCC_1997 LTLHPLEDGSGSKFQVHSR-----------------------PYGERDVD MSMEG_0408|M.smegmatis_MC2_155 LTLHPADGGSVLSFQIHSR-----------------------PYGERGAD Mvan_1003|M.vanbaalenii_PYR-1 LMLHRTDDADGWTFEVHSR-----------------------PYGDRDAD Mb2074c|M.bovis_AF2122/97 VVVNGPDESGVRGVSVYSR-----------------------GDVGTG-- Rv2048c|M.tuberculosis_H37Rv VVVNGPDESGVRGVSVYSR-----------------------GDVGTG-- MUL_2266|M.ulcerans_Agy99 VVVGSPDDSGARAVSVYSR-----------------------GDAGSD-- MAV_2450|M.avium_104 VVVDGPDDSGARAVSVFSR-----------------------ADAGAG-- MLBr_00135|M.leprae_Br4923 VVVAAADESSRRAVSVYSR-----------------------GDQSHGG- MMAR_1180|M.marinum_M IGVAGADGGARRAFNVHARTGTGHRGETGWVLHASGILAAEPAA------ TH_4458|M.thermoresistible__bu ------DQRERREL------------------------------------ . Mflv_0405|M.gilvum_PYR-GCK WALNAEGVVASGVGD---SPAAAGDLEDPVDEAIERLNRMRPQELFETFA MAB_0939|M.abscessus_ATCC_1997 WSLNAEGTVVTGIGDDAEPAPEAAEPAEPVDAAIERMERMRPMELFEIFA MSMEG_0408|M.smegmatis_MC2_155 WSLNAEGTVDTAGSD---PDAAADEQSDPVDEVIERLERMRPQDLFETFA Mvan_1003|M.vanbaalenii_PYR-1 WSRNASGTVAAGVGD-----AAPDAAADPVDNAIERLTRTRPQQLFDAFA Mb2074c|M.bovis_AF2122/97 WVLHAEGALRAGSAE---------PTADLAMWPPAGAVPVEVADGYQQLA Rv2048c|M.tuberculosis_H37Rv WVLHAEGALRAGSAE---------PTADLAMWPPAGAVPVEVADGYQQLA MUL_2266|M.ulcerans_Agy99 WVLHAEGSLGSGSPE---------PATDLSTWPPVGAVEVENADGYQQLA MAV_2450|M.avium_104 WLLHAEGVLRAGSAQ---------PATDLSAWPPVGAVPVDLGDGYEQLA MLBr_00135|M.leprae_Br4923 WLLNAEGLLEVDAAE---------ATVDLSLWPPEGAESVDISDAYPQLA MMAR_1180|M.marinum_M --------------------------AGQPPMAALPVTEFDVADFYQRLA TH_4458|M.thermoresistible__bu --------------------------------------------LESYLR : Mflv_0405|M.gilvum_PYR-GCK DLELAWGPTWSGSLKSLWLGEGEAIGDILVGAELAEQLGTEPMHPVLMDL MAB_0939|M.abscessus_ATCC_1997 DLELAWGPTWSGSLKSLWLGEGEAIGDVLVGEELAEQLGTEPMHPVLMDL MSMEG_0408|M.smegmatis_MC2_155 DLELAWGPTWSGSLKSLWLGDGEAVGDILVGAELAEQLGSEPMHPVLMDL Mvan_1003|M.vanbaalenii_PYR-1 DNDLAWGPAWCSSLRSLWVGTGEAVGDIAVGAELGEHLGREPIHPVLLDL Mb2074c|M.bovis_AF2122/97 ERGYGYGPAFRG-LTAMWRRGDEVFAEVALPADAGVSVTGFGVHPVLLDA Rv2048c|M.tuberculosis_H37Rv ERGYGYGPAFRG-LTAMWRRGDEVFAEVALPADAGVSVTGFGVHPVLLDA MUL_2266|M.ulcerans_Agy99 ERGYGYGPAFRG-LNAMWRRGDEVFAEVALPADAGVSVSGFGIHPVMLDA MAV_2450|M.avium_104 ERGYRYGPAFRG-LTSMWRRGDEIFAEVNLPTDAGVSTTGFGVHPVMLDA MLBr_00135|M.leprae_Br4923 ERGYAYGPAFQG-LVAIWRRGSELFAEVVAPT--GVVVDGMGMHPALLDA MMAR_1180|M.marinum_M DRGLHYGPPFCSVLGIGHEPADPDHIYAEVALPAGTDITGYGIHPALLDA TH_4458|M.thermoresistible__bu DR----------------------------------VAAELGVLPPLLDV : : * ::* Mflv_0405|M.gilvum_PYR-GCK CTGVAFPAFPALLAAEQGVNDLYLPLRYGQVSLQEKMPRRFYCRATWHEA MAB_0939|M.abscessus_ATCC_1997 CTGVAFPAFPALLAAEQGVNDLFLPLRYGQVTLKEKMPRRFYCRARWHES MSMEG_0408|M.smegmatis_MC2_155 CTGVAFPAFPALLAAEQGVNDLFLPLRYGQVTLAEKMPRRFYCRARWHRS Mvan_1003|M.vanbaalenii_PYR-1 CTGIAGAALLAAAAQTDADPELFLPLRYGRVEVRERMPRRFYCRARWQTG Mb2074c|M.bovis_AF2122/97 ALHAVVLSAESAERG---QGSVLVPFSWQGVSLHAAGASAVRARIAPVG- Rv2048c|M.tuberculosis_H37Rv ALHAVVLSAESAERG---QGSVLVPFSWQGVSLHAAGASAVRARIAPVG- MUL_2266|M.ulcerans_Agy99 ALHAVILASDGADDFGVPEGSVLVPFAWQGVTLHAAGASAVRARIAPAG- MAV_2450|M.avium_104 ALHAVMLASDGDDLP---AGSMLVPFSWQRVSLHAAGAAAVRARIVPVS- MLBr_00135|M.leprae_Br4923 VLHALGLAIENTQAT----TEMRLPFCWRGVSLHAGGAGRVRARFTSAG- MMAR_1180|M.marinum_M ALHPMAAALGAGADSE--SAAVRLPFVLSGVTLHATAATRLQVWLTRSSA TH_4458|M.thermoresistible__bu AAP------------------------LSTLGIDSLTAAELRARVERDLG : : . . Mflv_0405|M.gilvum_PYR-GCK PLDSETQVFDLEYLDRDGRHLGGVREFTVKRAPREALLRGLGGDA---TR MAB_0939|M.abscessus_ATCC_1997 PLDSETQVFDLDYLDRDGRHLGGIREFTVKRAPREALLRGLGGDA---TR MSMEG_0408|M.smegmatis_MC2_155 ALDSETQVFELEFVDLGGRALGGIREFTVKRAPREALLRGLGGDA---TR Mvan_1003|M.vanbaalenii_PYR-1 GIDSETQVFDLDFLDHDGRNLGGIREFTVKRAPREALLRGLGADA---TR Mb2074c|M.bovis_AF2122/97 -----PSAVSIELADGLGLPVLSVASMLARPVTDQQLRAAVSSSG---PD Rv2048c|M.tuberculosis_H37Rv -----PSAVSIELADGLGLPVLSVASMLARPVTDQQLRAAVSSSG---PD MUL_2266|M.ulcerans_Agy99 -----PSAVSIELSDGLGLPVLSVASMLARPVTDQQLRAAVSGAG---PD MAV_2450|M.avium_104 -----PSAVSIELADGLGLPVLSVASMVARPVTDQQLLAAVSNSG---PD MLBr_00135|M.leprae_Br4923 -----ADAIAVDIADSAGLPVLTVRSLVTRAMTAEQLRTAVTAAGGALEQ MMAR_1180|M.marinum_M D------TFTLYASDPAGAPVISIDTVVVRALPDLATLTPPTTAT-SSGR TH_4458|M.thermoresistible__bu ---------------------IVIPVAQLLNGPSVSDLAEWISTT-MVG- : . Mflv_0405|M.gilvum_PYR-GCK LLYTLGWHEVPVP----ESGDGAAPQGTWLIGGFDELAVSVPGCIPADR- MAB_0939|M.abscessus_ATCC_1997 LLYTLGWHEVAVPPVAGEGEESAASIGTWLIAGFDELAAKVPGCIPLNRE MSMEG_0408|M.smegmatis_MC2_155 LLYTLGWHEVPPP------PSADDAVGTWLIAGFDELAAKVPGCVPIDRN Mvan_1003|M.vanbaalenii_PYR-1 LIYRVGWRETSPP---VRDDGALGPSSTWLVAGLDALADDVPGSIRIGFD Mb2074c|M.bovis_AF2122/97 RLFEVTWSPQPSA-------AVEP----LPVCAWGTTEDS---------- Rv2048c|M.tuberculosis_H37Rv RLFEVTWSPQPSA-------AVEP----LPVCAWGTTEDS---------- MUL_2266|M.ulcerans_Agy99 RLFGVDWTAQPSA-------ELQP----VPVRIWGTVESEGDDDPG---- MAV_2450|M.avium_104 RLFELIWSAQPST-------AVQP----VSLLNWGATELDATDTDSDSGR MLBr_00135|M.leprae_Br4923 GPMDLVWSPIPLS-------SDGHGGGLPSVVSWADYCAGRGNDTG---- MMAR_1180|M.marinum_M GLWELAWPPLSSAGAPGAAVVAEPPAWVVVAEDPDAVSAGLRNGVRRPDL TH_4458|M.thermoresistible__bu --FGSTTPEPESAGVPGRSRPPD-----------GAVASGSGDGGR---- . Mflv_0405|M.gilvum_PYR-GCK ---------------TNPESLRQLLTDAHGRGLPFSGVVWRAARSDGDES MAB_0939|M.abscessus_ATCC_1997 ---------------TDPELLGEVLVAAKERGVPFSGVVWRAAGPGATES MSMEG_0408|M.smegmatis_MC2_155 ---------------TDLQVLGEVLSQAHARGAGFSGVVWRCATPGRKES Mvan_1003|M.vanbaalenii_PYR-1 RIWDPDRDGRVVLDPADDEHWRRLFALADERRAPVAGVVLGVTGRARPEE Mb2074c|M.bovis_AF2122/97 -----------------------------------AAVVFESVPLAG--- Rv2048c|M.tuberculosis_H37Rv -----------------------------------AAVVFESVPLAG--- MUL_2266|M.ulcerans_Agy99 -----------------------------------ASVVFESVPQAG--- MAV_2450|M.avium_104 -----------------------------------FAVLFESAPVAG--- MLBr_00135|M.leprae_Br4923 ------------------------------------VVVWEFGSASAGAQ MMAR_1180|M.marinum_M ------------------------------DAVRPCPPVVIWSLSPPDLR TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK --DAEVAARLEAEIAELLGAVHTVQ---GGEVKLPGGLWIVTERAVATES MAB_0939|M.abscessus_ATCC_1997 --TTESAARLEGEIAHLLSAVHTVQNSAQNGVKLPGGLWIVTERAVATES MSMEG_0408|M.smegmatis_MC2_155 GSASAESARLEAEITNLLSAVHAAQ---GPSVKLPGGLWIVTEHGVACES Mvan_1003|M.vanbaalenii_PYR-1 -PSADFAARLEAQIRDVLGAVHSLS---ALGAKPAAGLWIVTERAVAAEA Mb2074c|M.bovis_AF2122/97 ----DVVAGVYAATSSVLDVLQSWLT-----RDGAGVLVVMTRGAVALPG Rv2048c|M.tuberculosis_H37Rv ----DVVAGVYAATSSVLDVLQSWLT-----RDGAGVLVVMTRGAVALPG MUL_2266|M.ulcerans_Agy99 ----EVVAGVYAATAAVLEVLRSWLS-----RDGAGQLIITTRGAVALPD MAV_2450|M.avium_104 ----DVVTEVYAATRAVLPVLQSWLA-----RDGAGTLVVSTRGAMTLPG MLBr_00135|M.leprae_Br4923 -APVDSVAAVYSATHAALQVLQFWFG-----QDRAGTLVVLTRGAVGLVG MMAR_1180|M.marinum_M GDDDAVVSSMHSLTRHALAAVAAWLA--RPDTAETVLVVLTCRAVAINAY TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK GEPVDPVQAALWGFGRTAINEEPALRCRLVDCDGSPQAVQALAALLSTP- MAB_0939|M.abscessus_ATCC_1997 GEPVDPVQAALWGFGRTTINEEPALRAKLVDGDGSPEAVQALARLLVTP- MSMEG_0408|M.smegmatis_MC2_155 GEPVDPVQAALWGFGRTTINEEPALHCRLVDCDGSSEAVDLLAALLAAPG Mvan_1003|M.vanbaalenii_PYR-1 GEPVDPVQSALWGLGRTLIAEEPGLRCLLVDLDGSEDAGPALARLLGAP- Mb2074c|M.bovis_AF2122/97 EDVTDLAGAAVWGLVRSAQTEHP-GRIVLVDSDAPLDDSALAAVVTTGE- Rv2048c|M.tuberculosis_H37Rv EDVTDLAGAAVWGLVRSAQTEHP-GRIVLVDSDAPLDDSALAAVVTTGE- MUL_2266|M.ulcerans_Agy99 EDVTDLAGSAVWGLVRSAQTEHP-GRIVLVDTDAQLDEHAVAAVLAAGE- MAV_2450|M.avium_104 EDVTDLAGAAVWGLVRSAQTEHP-GRIVLVDTDAPLDADAVAAVLAVGE- MLBr_00135|M.leprae_Br4923 EGISDLAAAAVWGMVRSAQSEHS-GKIVLIDTDSAVD---VAVLADLGE- MMAR_1180|M.marinum_M ERAPNPAQAAVWALLHSAQSEHPGRIRLVDTDHAASSTDTLLQLLGSCT- TH_4458|M.thermoresistible__bu -----------WIELLNQMPEVS--------------DDTVDELLR---- * . * . Mflv_0405|M.gilvum_PYR-GCK VDEPELAVRQGKLLASRLLPWSRSGHLTVPRGGD-YVLAPTERGAIDNLR MAB_0939|M.abscessus_ATCC_1997 VDEPEIAVRQGKLLASRLLPWSRTGHLTVPRGSD-YVLAPTERGAIDNLR MSMEG_0408|M.smegmatis_MC2_155 IQEPEIAVRQGKLLASRLLPWARSGHLTLPRGGD-FVLAPTERGAIDNLR Mvan_1003|M.vanbaalenii_PYR-1 GDEPELALRQGRLLVPRLLPWSRSGQLAIPRGTD-YVLAPTERGVLDNLR Mb2074c|M.bovis_AF2122/97 ---PQVLWRRGEVYTARVHGSRAVGGLLVPPSDRPWRLAMSTAGTFENLR Rv2048c|M.tuberculosis_H37Rv ---PQVLWRRGEVYTARVHGSRAVGGLLVPPSDRPWRLAMSTAGTFENLR MUL_2266|M.ulcerans_Agy99 ---PQVLWRNGEVYTARVHGSRAVAGLLVPPGDGPWRLGMSTAGTFENLR MAV_2450|M.avium_104 ---PQTLLRNGTVYTARVLGSRAVGALLVPPEDGPWRLGMSSYGTIENLR MLBr_00135|M.leprae_Br4923 ---SQLLVRCNTVHAARLS--PAPQLLALPVGESMWRLAADGGGTLEDLV MMAR_1180|M.marinum_M --GTGGEPQLALRAGVAHMPRLAPARALTPPPTPHWRLITSGSGDLADLT TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK LTDSEVPPPAE--GYVQVRVEAAGLNFRDVLNVLGLYPG---------DP MAB_0939|M.abscessus_ATCC_1997 ITEKEVPAPDE--GYVQVRVEAAGLNFRDVLNVLGLYPG---------DP MSMEG_0408|M.smegmatis_MC2_155 LTETDVPEPDE--GYVQVRVEAAGLNFRDVLNVLGLYPG---------DP Mvan_1003|M.vanbaalenii_PYR-1 VSETEVTAPPE--GHVQVRVEAAGLNFRDVLNALGLYPG---------DP Mb2074c|M.bovis_AF2122/97 LELIPDADAPLGPGQVRVAVSAIAANFRDVMIALGLYPD---------PD Rv2048c|M.tuberculosis_H37Rv LELIPDADAPLGPGQVRVAVSAIAANFRDVMIALGLYPD---------PD MUL_2266|M.ulcerans_Agy99 LEPIPDADAALQPGHVRVALSAMAANFRDVMIALGLYPD---------PD MAV_2450|M.avium_104 LEPIPDADAPLGPGQVRVATSALAANFRDVMIALGLYPD---------PD MLBr_00135|M.leprae_Br4923 IQPCPEVQAPLQAGHMRVAVAAVGVNFRDVVAALGMYPG---------QA MMAR_1180|M.marinum_M LAPTPAP-AELGPGQIRVQIRAAGLNSDDVAVASAATSHRDAGGEGQQDH TH_4458|M.thermoresistible__bu ------------------QLLAAGENHDDTQLH----------------- * . * *. Mflv_0405|M.gilvum_PYR-GCK GPIGGDFAGTVTQLGEGVTGLDVGQRVYGSMQGAFAS-RFNVPGQFLAPI MAB_0939|M.abscessus_ATCC_1997 GPIGGDFAGIVTQLGEGVTGVEVGQRVYGSMQGAFGS-RFNVPAQFLAPI MSMEG_0408|M.smegmatis_MC2_155 GPIGGDFAGTVTQLGAGVSGLEIGQRVYGSMQGAFAS-RFNVPAQFLAPI Mvan_1003|M.vanbaalenii_PYR-1 GPIGGELAGVVTAPGPDVDGFDVGQRVFGFAVGAFAS-RVNVPVQFLAPV Mb2074c|M.bovis_AF2122/97 AVMGVEACGVVIETSLNKGSFAVGDRVMGLFPEGTGT-VASTDQRLLVKV Rv2048c|M.tuberculosis_H37Rv AVMGVEACGVVIETSLNKGSFAVGDRVMGLFPEGTGT-VASTDQRLLVKV MUL_2266|M.ulcerans_Agy99 AAMGVEGAGVVVETASPDGRFAVGDRVVGLFPEGTGT-IAITDHRLLVKI MAV_2450|M.avium_104 AVMGIEASGVVIETASQDGRVAVGDRVMGLFPDGTGT-VATTDQRLLVKV MLBr_00135|M.leprae_Br4923 PPLGAEGAGVVIEIGPEVTGVAVGDAVMG-FLGGAGP-LAVVHQQLITQM MMAR_1180|M.marinum_M QGLGVEAAGIVIDTAGDVDDLAPGDAVMGIFPNNAFAPTAATDHRAVVAI TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK PDGVSAVEAATIPAAALTVR-LSFDWAQVKSGDKVLIHAASGGVGLAAVQ MAB_0939|M.abscessus_ATCC_1997 PDGISGVEAATIPAAALTVR-LSFDWAQLKPGDKVLIHAASGGVGLAAIQ MSMEG_0408|M.smegmatis_MC2_155 PDGIGAVEAATIPAAALTVR-LAFDWAQLKPGDKVLIHAASGGVGLAAIQ Mvan_1003|M.vanbaalenii_PYR-1 PEGISAVAAATTPAAVLTAG-LAFDWAALRAGDRVLIHAASGGVGLAAVQ Mb2074c|M.bovis_AF2122/97 PAGWSHTAAATTSVVFATAHYALVDLADVQPGQRVLIHAGTGGVGMAAVQ Rv2048c|M.tuberculosis_H37Rv PAGWSHTAAATTSVVFATAHYALVDLAAARSGQRVLIHAGTGGVGMAAVQ MUL_2266|M.ulcerans_Agy99 PAGWSDTAAATTSVVFATAFYALRDLASVQPGQRILVHAATGGVGMAAVQ MAV_2450|M.avium_104 PAGWSHTAAATASVVFATAYYALVDLADARPGQRVLVHAAAGGVGMAAVQ MLBr_00135|M.leprae_Br4923 PQGWSLAEAAAVPVVFLTALFGLADLAGIRAGESVLIHAGTGGVGMAAVQ MMAR_1180|M.marinum_M PPGWSCPQAASVPVAFVTAYSALIDIAALRAGQRVLIHSGAGAVGRAAIR TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK MAQQCGAEVYATASTFKRATLRKLG--VKHVYDSRTTDFAEQILADTDGA MAB_0939|M.abscessus_ATCC_1997 MAQQFGAEVFATASTFKRATLRKLG--VKYVYDSRTTDFADQILADTDGA MSMEG_0408|M.smegmatis_MC2_155 MAQQSGAEVFATASTFKRSTLRRLG--VKYVYDSRTTDFADQILADTNGA Mvan_1003|M.vanbaalenii_PYR-1 LARQRGATVFATASGYKRPMLRAMG--VDHVYDSRTTDFADQILADTDGA Mb2074c|M.bovis_AF2122/97 LARHLGLEVFATASKGKWDTLRAMGFDDDHISDSRSLEFEDKFRAATGGR Rv2048c|M.tuberculosis_H37Rv LARHLGLEVFATASKGKWDTLRAMGFDDDHISDSRSLEFEDKFRAATGGR MUL_2266|M.ulcerans_Agy99 LARHWGLEVFATASKGKWDTLRAMGFDEDHIGDSRSLEFEDKFRAATGGR MAV_2450|M.avium_104 LARHLGLEVFATASRGKWDTLRDMGFDDDHLGDSRGLDFEDKFRAVTGGA MLBr_00135|M.leprae_Br4923 FARHWGVEIFVTASRGKWDTLRDMGFDDDHIGDSRTLEFEEKFLAVTDGR MMAR_1180|M.marinum_M IAQHLGAEVFATADPAEQHILRGLGIPEDHIASSRARDFGDTLAAATGGR TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK GVDVVLNSLTSEGFIEATLRATAQHGRFAEIAKRDIWTVEQMAAARPDLA MAB_0939|M.abscessus_ATCC_1997 GVDVVLNSLTSEGFIEATLRATAKNGRFAEIAKRDIWTTEQMAQSRPDIA MSMEG_0408|M.smegmatis_MC2_155 GVDVVLNSLTSAGFVEATLKATAQGGRFAEIAKRDIWSHEQMAEARPDIA Mvan_1003|M.vanbaalenii_PYR-1 GVDVVLNSLTNDGFVAATVRATARNGRFAEIAKRDIWSPEQMAAARPDID Mb2074c|M.bovis_AF2122/97 GFDVVLDSLAGE-FVDASLRLVAPGGVFLEMGKTDIRDPGVIAQQYPGVR Rv2048c|M.tuberculosis_H37Rv GFDVVLDSLAGE-FVDASLRLVAPGGVFLEMGKTDIRDPGVIAQQYPGVR MUL_2266|M.ulcerans_Agy99 GMDVVLDSLAGE-FVDASLRLVAPGGVFLEMGKTDIREAAVVAQQHTGVR MAV_2450|M.avium_104 GMDIVLDSLSGD-SVDASLRLVAPGGIFLEMGKTDIRDPEVVAAEHPGVR MLBr_00135|M.leprae_Br4923 GVDVVLDSLAGD-FVDASLRLLVRGGRFLEMGKTDIRDAQEIAANYPGVQ MMAR_1180|M.marinum_M GMDVVLNDLRGD-LVDASLRLLAAPGCFVEIARRDIREATDVAQTHPGLR TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK YEIVALDTVMFTEPDRIRDLLTEVSAGLRDGAWTPLPAEVYPLTEARAAF MAB_0939|M.abscessus_ATCC_1997 YEIVALDTVMFQEPDRIRVLLTEVSEGLAKGEWTPLPAEIYPLTEARTAF MSMEG_0408|M.smegmatis_MC2_155 YEIVALDTVMFTEPDRIRDLLTEVSDGMARGEWTPLPAEIYPITEARSAF Mvan_1003|M.vanbaalenii_PYR-1 YEVLALDAVMQQDPDRIQLLLADLADSLARGETAPLPFEAYPLAEATTAF Mb2074c|M.bovis_AF2122/97 YRAFDLFEAG---PDRIAQILAELATLFGDGVLRPLPVTTFDVRRAPAAL Rv2048c|M.tuberculosis_H37Rv YRAFDLFEPG---PDRIAQILAELATLFGDGVLRPLPVTTFDVRCAPAAL MUL_2266|M.ulcerans_Agy99 YRAFDLFEAG---PDHIAQILAELAALFSEDVLRPLPVTTFDVRRAPAAL MAV_2450|M.avium_104 YRAFDLFEAG---PDRIARLLDELAAMFGEDVLRPLPVTRFDVRRAPAAL MLBr_00135|M.leprae_Br4923 YRAFDLSEAG---PVRMQEMLCEVRELFDTQVLHRLPVTSWDVRCAPAAF MMAR_1180|M.marinum_M YVVYDISTAT---PERLQRTWAAVSELINAAVIEPPPVTAYGLLRARQAF TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK RRMQQARHIGKIVVQIPNP-LQPQPDRSYLITGGLGAIG-LHTAGYLAQL MAB_0939|M.abscessus_ATCC_1997 RRMQQARHIGKIVCQMPNP-LAPRPDRTYLITGGLGAIG-LHTAAYLAQL MSMEG_0408|M.smegmatis_MC2_155 RRMQQARHIGKIVLQVPKP-LQPQQDRSYLITGGLGAIG-LHTAAYLAQL Mvan_1003|M.vanbaalenii_PYR-1 RRMQQARHTGKIILQMPKP-LQPHGDRSYLITGGLGALG-LHAAAYLAQL Mb2074c|M.bovis_AF2122/97 RYLSQARHTGKVVMLMP----GSWAAGTVLITGGTGMAGSAVARHVVARH Rv2048c|M.tuberculosis_H37Rv RYLSQARHTGKVVMLMP----GSWAAGTVLITGGTGMAGSAVARHVVARH MUL_2266|M.ulcerans_Agy99 RYLSQARHVGKVVLTMP----DAWAAGTVLITGGTGMAGSALARHVVAHH MAV_2450|M.avium_104 RYLSQARHVGKVVMTMP----DAWTAGTVLITGATGMAGSAVARHVVTRH MLBr_00135|M.leprae_Br4923 RFMSQARHIGKVVLTMPSALADGLAEGTVLITGASGAIGGVLARHMVSAY MMAR_1180|M.marinum_M RDISEARPSGKVVLIAPAA---LDPAGTVLITGGTGMLGGLFAEHLLTHY TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK GAGDIVLTSRRAPDAAAQQAIADIADRTKARLHVFTADVGVEADVAALLE MAB_0939|M.abscessus_ATCC_1997 GAGDIVLTSRRAPDTDAQRVIGEITERSKTRIHVFTADVGAESEVAGLLE MSMEG_0408|M.smegmatis_MC2_155 GAGDIVLTSRRDPDESAQRAIDEITERHKCRIHTYAADVGDEAQVADLLA Mvan_1003|M.vanbaalenii_PYR-1 GAGDIVLTGRRMPDAATERAISEIAERYHCRIHTFAADVGDESAVRDLLE Mb2074c|M.bovis_AF2122/97 GVRNLVLVSRRGPDAPGAAELVAELAAAGAQVQVVACDAADRAALAKVIA Rv2048c|M.tuberculosis_H37Rv GVRNLVLVSRRGPDAPGAAELVAELAAAGAQVQVVACDAADRAALAKVIA MUL_2266|M.ulcerans_Agy99 GVRQLVLVSRRGPDAPGAAELAEELSAFGAQVQVVACDAADRAALAKLIA MAV_2450|M.avium_104 GARNLVLVSRRGLDAPDAAELVAELTAAGAHAEVVACDAADREALAKVIA MLBr_00135|M.leprae_Br4923 GVRHLVLASRRGDRAEGAVELAAELVGAGAKIQVVACDVADNDAVRGLFA MMAR_1180|M.marinum_M GVRRLLLTSRRGPSGVGAAELAERLNGLGAQVTISACDCADPAQLAALID TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK RIRAELPPLAGVAHLAGVLDDALLSQQSVERFRTALAPKAFGAVHLDRLT MAB_0939|M.abscessus_ATCC_1997 RIRAELPPLAGVAHLAGVLDDALLGQQSVERFRTTLAPKAFGAEYLDRLT MSMEG_0408|M.smegmatis_MC2_155 RIRAELPPLAGIAHLAGVLDDALLSAQNPERFRTTLAPKAYGASHLDRLT Mvan_1003|M.vanbaalenii_PYR-1 RIRTELPPLAGVAHLAGVLDDALLPQQSPERFRTTLAPKAFGAWHLHRLT Mb2074c|M.bovis_AF2122/97 DIPVQHP-LSGVIHTAGALDDAVVMSLTPDRVDVVLRSKVDAAWHLHELT Rv2048c|M.tuberculosis_H37Rv DIPVQHP-LSGVIHTAGALDDAVVMSLTPDRVDVVLRSKVDAAWHLHELT MUL_2266|M.ulcerans_Agy99 DIPMQHP-LSAVIHTAGALDDAVVTSLTPERIETVLRAKVDAAWNLHELT MAV_2450|M.avium_104 DIPMQHP-LTGVIHAAGVLDDAVVTSLTPQRIDTVLRAKVDAAWNLHELT MLBr_00135|M.leprae_Br4923 QLSREFPPVRGVIHAAGVLDDGAITSLTPDRVDTVLRAKVDAAWNLHEAT MMAR_1180|M.marinum_M SIPTEHP-LTAVIHAAGVLDDAVTSQLTAQQLDTVLAAKADSAWHLHQLT TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK RVDDLDFFLVSSSVSSLFGSPGQSNYATANAFLDGLVAQRRAQGLPATGV MAB_0939|M.abscessus_ATCC_1997 KGDDLDFFIVSSSVSSLFGSPGQSNYATANALLDGLIAQRRAQGLPATGI MSMEG_0408|M.smegmatis_MC2_155 RDDDLDFFIVSSSVSSLFGSPGQANYATANAMLDGLVAKRRAQGLVATGI Mvan_1003|M.vanbaalenii_PYR-1 RDTELEFFIVYSSGSSVLGSPGQANYATANAVLDGLVAHRKARGLPATGV Mb2074c|M.bovis_AF2122/97 RDLDVSAFVMFSSMAGLVGSSGQANYAAANSFLDALAAHRRAHGLPAISL Rv2048c|M.tuberculosis_H37Rv RDLDVSAFVMFSSMAGLVGSSGQANYAAANSFLDALAAHRRAHGLPAISL MUL_2266|M.ulcerans_Agy99 RDMDLSAFVMFSSMAGLVGSSGQGNYAAANSFLDGLAVHRQAHGLPAISL MAV_2450|M.avium_104 RDLDVGAFVMFSSIAGLAGASGQGNYAAGNSFLDGLAAHRRAHGLPAISL MLBr_00135|M.leprae_Br4923 RDLDLLMFVLCSSIAATVGSPGQGNYSAANAFLDGLAAYRQAAGLAGTSL MMAR_1180|M.marinum_M ANTELAAFVLFSSAAGVLGAPGQANYAAANAVLDALARERGPG---ATSL TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK NFGPWARGGMASSEAAAANIS---AQGLIPLEPSAALTAMAEVVANGTAQ MAB_0939|M.abscessus_ATCC_1997 NFGPWGQGGMASSEAATANIS---AQGLIPLDPSAALAALAEVVANGTGQ MSMEG_0408|M.smegmatis_MC2_155 NFGPWGQGGMASSEAATANIT---AQGLIPLDPSAALHALAEVIANGSGQ Mvan_1003|M.vanbaalenii_PYR-1 NWGPWAQGGMATSDAARANLG---AQGLIPLEPTAALNALGEIVAHGIAS Mb2074c|M.bovis_AF2122/97 GWGLWDQASAMTSGLATVDFKRFARDGIVAMSSADALQLFDTAMIVDEPF Rv2048c|M.tuberculosis_H37Rv GWGLWDQASAMTGGLATVDFKRFARDGIVAMSSADALQLFDTAMIVDEPF MUL_2266|M.ulcerans_Agy99 GWGLWDQASNMTGGLAAVDFKRFARDGIVAMSSDEALGLLDTAMVLGEPF MAV_2450|M.avium_104 GWGLWDQASAMTGGLGAADLARFGRDGIVAMSSQEALELMDTALIVDEPF MLBr_00135|M.leprae_Br4923 AWGLWEQPGGMNAHLSSRDLARISRSGLAPMNPAQALELFDAALVIDHPF MMAR_1180|M.marinum_M AWGYWQPSSGMTGHLDARDQARLTRSGMVPITTSAGLALFDAALGVQHPN TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK ATVLKANWQRAAKVLGS-SRPPILDLVLPSAVGEITGDS--------ELL MAB_0939|M.abscessus_ATCC_1997 ATILKANWQRAAKVLGS-SRPPILDLVLPSAVGEVTGDS--------ELL MSMEG_0408|M.smegmatis_MC2_155 ATVLKANWQRAAKVLGS-ARPPILDLVLPSAAGEATGDS--------ELL Mvan_1003|M.vanbaalenii_PYR-1 AVVLKANWQRAAKLLGA-TRPPILDHVLPSAVAAGPGDS--------ALL Mb2074c|M.bovis_AF2122/97 MLPAHIDFAALKVKFDGGTLPPMFVDLINAPTRRQVDDSLAAAKSKSALA Rv2048c|M.tuberculosis_H37Rv MLPAHIDFAALKVKFDGGTLPPMFVDLINAPTRRQVDDSLAAAKSKSALL MUL_2266|M.ulcerans_Agy99 MLPAHIDFAALRVKFDGGTLPPMFVDLINAPTRRQVDDSLAAAKSKSALL MAV_2450|M.avium_104 LLPAHIDLAALRVKFDGGTLPPMFVDLINAPTRRQVDDSLAAAKSKSALL MLBr_00135|M.leprae_Br4923 MVTALLDRAALDAQAQAGALPPLFSRLVRRSRRRQIEDPGDATQSKLALV MMAR_1180|M.marinum_M LIPAPLSTRALAALARESSLPPIFSALISTRPQAAMADSR-------ALG TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK KQLQEIPVPQRAGFVTEFLQKEVQNFLRLAQPPAATS--RFLDLGTDSLM MAB_0939|M.abscessus_ATCC_1997 KQLMEIPVPQRAGFVTEFLQREVQNFLRLAQPPAATS--RFLDLGTDSLM MSMEG_0408|M.smegmatis_MC2_155 KQLMEIPIPQRAGFVTEFLQREVQNFLRLASPPAASS--RFLDLGTDSLM Mvan_1003|M.vanbaalenii_PYR-1 KQLQDVPEAQRGSFVTEHLQRELQQILGLAQPPAATG--RFLELGMDSLM Mb2074c|M.bovis_AF2122/97 HRLHGLPEDEQHAVLLDLVRSHIATVLGSASPEAIDPDRAFQDLGFDSLT Rv2048c|M.tuberculosis_H37Rv QRLEGLPEDEQHAVLLDLVRSHIATVLGSASPEAIDPDRAFQELGFDSLT MUL_2266|M.ulcerans_Agy99 QRLEGLPEDEQHAILLNLVRSHIATVLGNSSPDAIDPDRAFQELGFDSLT MAV_2450|M.avium_104 QRLEGLPEDEQQAVLLDLVRSNIATVLGSSSPEAIHPDRAFQELGFDSLT MLBr_00135|M.leprae_Br4923 QRLQGLAANRQLELLVGVVCLQAAAVLGRPSPEDIDPNTKFQDLGFDSLT MMAR_1180|M.marinum_M ARLAGLTPEQQHAMLTKLVLTATAAVLAHPDPAAMDPDQPFKDLGIDSLS TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK AIELRNRLHSQFGGAFTINATAVFDYPTIGGLAEYLVAQLPDAETPQAAP MAB_0939|M.abscessus_ATCC_1997 AIELRNRLHSQFGGKFTINATAVFDYPTIGGLAEYLVGQLPDADAESAEA MSMEG_0408|M.smegmatis_MC2_155 AIELRNRLHSQFGGKFTINATAVFDYPTIGGLAEYLVGQLPDAEAPETA- Mvan_1003|M.vanbaalenii_PYR-1 AVELRNRLVGQFGSGFTITATAVFDYPTIGALAEYLAAQTPESTEEGTEM Mb2074c|M.bovis_AF2122/97 AVEMRNRLKSATG--LSLSPTLIFDYPNSAALAGYMRRELLGSSPQ-DTS Rv2048c|M.tuberculosis_H37Rv AVEMRNRLKSATG--LALSPTLIFDYPNSAALAGYMRRELLGSSPQ-DTS MUL_2266|M.ulcerans_Agy99 AVEMRNRLKSATG--LALSPTLIFDYPNSAALAGYMHRELVGASPQSDTT MAV_2450|M.avium_104 AVEMRNRLKAATG--LALSPTLIFDYPNSAALAGYMYRELVGTSEQ-PTA MLBr_00135|M.leprae_Br4923 AVELRNRLKSATG--LTLPPTVIFDHPTPTAVAEYVAQQMLKSRPA---- MMAR_1180|M.marinum_M ALELRGALSAQSG--VDLPATLIFDHPSPASVAVHLADLLSVAAVPAAAA TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK -------QSESEPGPDVTE------------------------------- MAB_0939|M.abscessus_ATCC_1997 PPAVESAEAESGAGPAAASDAVSELKE----------------------- MSMEG_0408|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_1003|M.vanbaalenii_PYR-1 KTADPDGQPATVGHADVVLQTS---------------------------- Mb2074c|M.bovis_AF2122/97 AVAAGEAELQRIVASIPVKRLRQAGVLDLLLALANETETSGQDPALAPTA Rv2048c|M.tuberculosis_H37Rv AVAAGEAELQRIVASIPVKRLRQAGVLDLLLALANETETSGQDPALAPTA MUL_2266|M.ulcerans_Agy99 AEAPGEAELQRVVASIPVKRLRQAGVLELLLALANETGGNGQAAVTAETS MAV_2450|M.avium_104 AAAPGEAEIQRVVGSIPVKRLRQAGVLELLLALANESTGTAQSATPAVTT MLBr_00135|M.leprae_Br4923 --ESGDETSQAVEPKVEEVSVHA--------------------------- MMAR_1180|M.marinum_M AQVGKRAAEPADDRLAYLDQAAFLGLRAGYGSLIQMIWIYDRAVDVEGLR TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_1003|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb2074c|M.bovis_AF2122/97 EQEIADMDLDDLVNAAFRNDDE---------------------------- Rv2048c|M.tuberculosis_H37Rv EQEIADMDLDDLVNAAFRNDDE---------------------------- MUL_2266|M.ulcerans_Agy99 EEDLADMDLDALVNAAFMNDDE---------------------------- MAV_2450|M.avium_104 EKDIADMDLDDLVNAALLDDDDE--------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MMAR_1180|M.marinum_M RFHRNLGCGLLGRRIERSPLPFARDRWVSAPVSQQIDFATTPRRRADVGA TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_1003|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb2074c|M.bovis_AF2122/97 -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 -------------------------------------------------- MAV_2450|M.avium_104 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MMAR_1180|M.marinum_M WADERARLPIDPEWGPGWHLGVVGLDDGGTAVSLVASHTIADAIAFGQAV TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_1003|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb2074c|M.bovis_AF2122/97 -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 -------------------------------------------------- MAV_2450|M.avium_104 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MMAR_1180|M.marinum_M VNAAEGRTQDLGYPAAGSRILRRALREDLRQTVNELPKIAHAFGGVVRRL TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_1003|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb2074c|M.bovis_AF2122/97 -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 -------------------------------------------------- MAV_2450|M.avium_104 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MMAR_1180|M.marinum_M RRDRQELQSSIKAAPPPPRMAGGDHSVEVPAVTAYIDLADWDACAKRLGA TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_1003|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb2074c|M.bovis_AF2122/97 -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 -------------------------------------------------- MAV_2450|M.avium_104 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MMAR_1180|M.marinum_M KSNSLVGGVACRLAARVGRVQGDGTVTLRIVVSLRTKDDTRGNALTAVDV TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_1003|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb2074c|M.bovis_AF2122/97 -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 -------------------------------------------------- MAV_2450|M.avium_104 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MMAR_1180|M.marinum_M AVDPAHAATDLREMHAKITRAILEGMEDLDNEFLAPLPLAAITPRWVARR TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_1003|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb2074c|M.bovis_AF2122/97 -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 -------------------------------------------------- MAV_2450|M.avium_104 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MMAR_1180|M.marinum_M LVGMAAGGPTLPVTCSNVGDVPPAANRPDGTDADFAYIRLVEPDIAKSVL TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_1003|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb2074c|M.bovis_AF2122/97 -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 -------------------------------------------------- MAV_2450|M.avium_104 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MMAR_1180|M.marinum_M EGTGGRMLLASGRGRGKMCIGISAYLVGHSNTKDELREVVSRTFAEFGLN TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK ----- MAB_0939|M.abscessus_ATCC_1997 ----- MSMEG_0408|M.smegmatis_MC2_155 ----- Mvan_1003|M.vanbaalenii_PYR-1 ----- Mb2074c|M.bovis_AF2122/97 ----- Rv2048c|M.tuberculosis_H37Rv ----- MUL_2266|M.ulcerans_Agy99 ----- MAV_2450|M.avium_104 ----- MLBr_00135|M.leprae_Br4923 ----- MMAR_1180|M.marinum_M AEIDC TH_4458|M.thermoresistible__bu -----