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MENEERLRKYLQKAANDLRKSNKRVRELERRTVEPVAVVGMACRFPGGADSPDGLWQMVSEGRDVLSEFP SDRGWDLGGLYDPEPDRVGYVHARAGGFLDGVADFDAGFFGISPREALGMDPQQRLILEIAWETLESASI DPQSLRGSQTGVFAGTMTSCYGVGIDNVTSAVSGRVAYAFGFEGPAVTVDTACSSSLVAIHQACQSLRGG ECSMALAGGVTVMATPDVFAEFARQRGLSADGRCKAFAASADGTGFGEGAGLVLLERLSDARRNRHPVLA VIRGSAVNQDGASNGLTAPNGPAQERVIRSAVAAAGLRVADVDVVEAHGTGTTLGDPIEAHALLATYGAD RDAEQPLWLGSVKSNMGHTQAAAGVAGLIKMIQAINHAVLPPTLHVDAPSPHIDWSAGAVRLLTEAVPWP DTGRARTAGISSFGISGTNAHLIAQEAPQESTADPSPSDVCEPLFRVWPVSGRTAEALNAQAERLGQYLV DHPDLDLTDLAYSLATTRAHHAYRAAVTVPGDTVNTRDDLLAGLRSLAVDQFHPGVTYHHYRLGQAGKTV FVFPGQGAQYAGMGAGLYRHHPVFTTAIDEICAVMDEHLDVPLRDVMFTEPGLLQQTVYAQPALFAFGVA MHAVLTQAGVNPDYLLGHSVGELTAAHVAGVLSLEEAAVLVCARGRLMQSCTPGAMMAISASEPAVAAML ENHPEVVIAAVNGPTSVAVAGPAEQLNALREHCNISNHKVTLLRVSHAFHSPAMDPILAEFEAIAKRLTY RPHSVPIMSNLTGSLATVEQLTSARYWAQHLRKPVRFYDGVTRLLAGGEQAFVELSPHPVLAAAITDTLT GVTDRVGSAVVTTLRRDRPDMDMVASAIANLHVHGHSPSWQKIYPGATTVELPTYPFQHRRYWLDPAPRA DVSAAGLDQPEHPLLAAVTELADQDQIVLSGRLSTSAHRWLAGHQLGDTVVLPATALIDMALYAGEHTGC PTIDELVLQTPLTLTPDAATDLQISVAAPDEQNRRTFSVHARTSEHPHQHSTWVLHASGTLSNAPSTTPP TKPLPGPQAITKVNQESFYDQLAQHGLHYSEAFRSIQGIGKDPLNPDAICAEVALPADIETHGYGIHPAL LDAALHPLTAALADTNTNSGPQLPFAIAGITLHATGASRMHVQLEPTATDTFRLSATDPVGAPVITIDSL TVRSLPDTDLTQPPTHKAQQGIFELTWPALPAETFPATGVLPPWALISPHPENLSPDLNQSPTYPNLTAL PTCPPLVIWDLTTPQPPQSDLLHQVHTLTQHTLAGLQNWLNRSDTLQAHLVVLTRHAVTTSPHDLAPDPA QAATAALIHTTQNEHPNRITLIDIDNTPTTSQTLTNILTTLTNPTSAPTEPQLALRHGTPHTPRLTPTQV LTPPAAPNWELATTGKGDLANLALLPTPPHTELGPGQIRVAVRAAGLNFRDVVVALGAIGEEGLGGEAAG IIIDTGPDVTAFRRGDAVMGLFPNNAFAATAVTDHRMVVPIPAGWSFAAAASIPVAFLTAYGAMVELGAL AAGRRVLIHAGAGGVGQAAIQIARHFGAEVYATAHPSKHHVLKALGVSGDRIASSRTFDFVDVFNQGTNG EGMDLVLNSLAGDFVDNSLRLLSQGGRLIEIGKTDIRVPNEVAAAHPGVIYRTYDLSSETPDRISQLWAA LIEMISAGVLRPLPTTSYGLLQATQALRHMSQGRHTGKIVLLPPGVFNSEGTVLVTGGTGMLGGVFAERL VAHYGARHLLLVSRSGPDAAGADELYQRLTQLGAQVTITACDTSNPDELAAVLAGIPPQHPLRAVVHTAG IVDDAVTTELTHEQLDTVLTAKADTAWHLHQLTTDADLDAFVVFSSVAGVLGAPGQANYAAANAFLDALA HQRHRNHLPATSLAWGYWQTTSGMTAHLDTVDQARLTRNSLTPITTEHGLAMFDVALACQHPCLVPAPLN TQVLAGYARQNALPAILSAVTTTRRQATTTNTETFTSRLASQTPQQQLAILSDLVTDMTAAVLAHPDSAA LDADLPFKDLGIDSLSALELRNSLARHTGLTLSATLVFDHPTPTAIAHHLVDQLSAAAPPAPVATPVKAN AEEPVVVVGMACRLPGGIESAAGLWDVVSGAADVMGAFPTDRGWDVAGLFDPDPDSVGKTYTRYGGFISS AAEFDAEFFGISAREAAAMDPQQRVLLEVCWEALEHAGIEPGTLEGSNTGVFIGAYAQRYGDSDSDSGEG FALTGGATSVASGRVAYVLGLQGPAITVDTACSSSLVAAHLACQSLRNGESSLALAGGVTIMATPAPFIE FARQRGLAADGRCKAFAAAADGTGWGEGAAVLVLERLSDARRNRHPVLAVIAGSAVNQDGASNGLSAPNG PAQQRVIAQAAANAGIALDQVDVVEAHGTGTTLGDPIEAGALIATYGTHRDPEHPLWLGSVKSNIGHTQA AAGAAGLIKMIQAMRHGVLPKTLHVNAPTPQVDWSAGTVRLLTETMPWPDTDHLRTAAVSSFGVSGTNAH LIVQQGSPGPAVAVHQASPSQECSLGVWPLSARSSAGLSAQAHRLHEYLLGHSDLDLIDLAYSLATTRTH HSYRAAVTVPGCTDNAHHDLLGGLTALAAGQTHPFVANHYCRAGQNGKTVFVFPGQGGQYPAMAAELYRQ HPGFATAVDECDAELRPYTGWSVRDVICQDPDAPSLELVEVIQPVLFAVMIALAETLRGYGIVPDAVIGH SQGEIAAAYIAGALTLAEAAKVVALRSAALAQLAGTGTMASVLLSPEELRPLLQPWNTQISIAAINGPAH TIISGDTTAVEQFIGTCEDGGVQIRPIAVDYASHSAHVERLREHLLHELADLNPQPARIPLYSTVASELS EHPLDTTAMDAEYWYRNLREPVEFYSCVAQLLAHSERVFVELSPHPVLASALTDALADTGQLTQSAVVTT LRRDRPDMDMVASAIANLHVHGHSPSWQKIYPGATTVELPTYAFQRRHYWLAAPTPTPATVSDPAEVALW DAVNDDAVDTVARVLRIDNAQSMVSLGPMVRALREWRKELGDRSVVGQLRYQVGWRNVTPNTFPQTRQRW LVLTLPEQSDDVWVAGFSARFADSVAMLAIDPHMFDRNSLAALLADEATRNKCDGVVSFMALRERTHQDF RGISTALLSTLHITQAYGDSGLDLPLWVITQGGAQVNPDEDLTPSQSAVWGLGQSACLEHPTWWGGLVDL PVSPAPQDFNRLQAILTCQQSEDQLAIRAAGVSARRLHKASLPQDRMRTWKISGTALVTGVTGHLGQHIA RWLAQAGASHLVLLSRTAAEHPQVAELEKELNSAGITTTSISVDVTDRDALAAVVAETRIEHGPIHTVVH AAAHIGLVTTAETTIDEFIKSFAAKALGAENLIAVLEDQPPQTFIMFSSAAATWGGTRQGAYAAANAYIE ALVTRLRGRGCRAIAPAWGAWTDDRTTTQEVVGYFSRIGLNQISPDIAFAALQQSLDVDDTLITIADVDW SQFRDVFTTTGRAHALLAELGTSQPQTAEIPAIAENSHFAAQLAKQAPQQQLATLIGLVTNVTAAVLAHP DPAVLDPDLSFKDLGIDSLSALELRNTLTRDTGLTLPATVVFDHPTPTAVAEHLLGLLSGVTGPTLAVVP TRVGVDVPVAVVGMACRLPGGIESAAGLWDVVSNGIDVMSGFPLDRGWDVAGLFDPDPDAEGKTYTRYGG FVADVAGFDAEFFGISAREAITMDPQQRVLLEVCWQALEHAGIDPTTLEGSDTGVFVGIGAQSYVSGHSG VEGYALTGASASVASGRVAYVLGLQGPAITVDTACSSSLVATHLACQSLRNGESSLALAGGATIMATPTP FIEFARQRGLAADGRCKAFAAAADGTGWGEGAAVLVLERLSDARRNRHPVLAVIAGSAVNQDGASNGLSA PNGPAQQRVISQALANAGLPFTHVDVVEAHGTGTTLGDPIEAGALIATYGTHRDPEHPLWLGSVKSNIGH TQHAAGAAGLIKMIQALNHAVLPATLHIDQPSPHIDWSTDTVRLLTEATPWPETEHLRTGAVSAFGVSGT NAHLIVQQAPPEVFESVPEPETARPSGQPLLRIWPVSAHTPAALTAQAERLSEYLTRHEDLSLTDLAYSL ACTRTHHPYRAAVTVPVDTSNPGHDLAAALRALAANQPHPYVTCHHYRARQPSKTVFVFPGQGGQYPAMA AELYRQHPGFATAVDECDAELRPYTGWSVRDVICQDPDAPSLELVEVIQPVLFAVMIALAETLRGYGIVP DAVIGHSQGEIAAAYIAGALTLAEAAKVVALRSAALAQLAGTGTMASVLLSPEELRPLLQPWNTQISIAA INGPAHTIISGDTTAVEQFIGTCEDGGVQIRPIAVDYASHSAHVERLREHLLHELADLNPQPARIPLYST VASELSEHPLDTTAMDAEYWYRNLREPVEFYSCVAQLLAHSERVFVELSPHPVLASALTDALADTGQLTQ SAVVTTLRRDRPDMDMVASAIANLHVHGHSPSWQKIYPGATTVELPTYPFQHRRYWLDPAPRADVSAAGL DQPEHPLLAAVTELADQDQIVLSGRLSTSAHRWLAGHQLGDTVVLPATALIDMALYAGEHTGCPTIDELV LQTPLTLTPDAATDLQISVAAPDEQNRRTFSVHARTSEHPHQHSTWVLHASGTLSNHPSRMFSPTTPFAA GRTPNAVDQDSFYEELAQHGVRYDGAFRALHSLENNPSDTDTTCAEVALPADTDVDGYGIHPALLDAALQ PLAAAFTDTDTDAPSAATPRMPFVITGVNLHATGARRLLVQLTATDADTFSLHATDPAGATVITINAVTL RALTDIGSLRTSGISRRGLLELAWPALPPDTFSTAAVLPPLALVSSHSDDLAHALGQSSQCTVYTDLAAV QPCPPLVLWDLTAGPDPTPTPEDGDTEDPLQRVHTLTRHTLAGLQNWLNRSDTTGTHLVILTRRAVTTVP DDRSPDPAHAATWAFAHSAQNEHPNRITLIDIDNTPATSQTLTNILTTLTNPTSAPTEPQLALRHGTPHT PRLTPTTTETTTTSPPLEFDPAGTVLITGGTGMLGAVFAEHMIARYGARHLLLVSRSGPDAPGADDLYQR LTQLGAQITITACDASDPTALAAVLANIPTEHPLRAVIHTAAVIDDAVVTELTVEQLDMVLAAKADTAWH LHRLTADINLDVFVVFSAAAAVLGAPGLANYAAANAFLDALAHHRHHHGLPATSLAWGYWQTPGIAAHLD TVSQARFTRNHLIPITTEHGLALFDAALACQQPNLVPAPLNTHTLARQARQGVLPAILSSLITTRRHATI GSVETLTAQLATQTPEQQLATLTRLVTTATAAVLAHPDPATLEPDLPFKDLGIDSLSALELRNTLTRDTG ASLPATLVFDHPTPSAIAQYLNIQLSGSSTTSRVQDPEEIEMQNLIAKIPAKQLIKSGVLNILREIADIE HSSSANEKQDNVATMNLDELLIALGDHKGENKNDH
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. marinum M | MMAR_3798 | - | - | 100% (5495) | type I modular polyketide synthase |
M. marinum M | MMAR_3799 | - | 0.0 | 92.89% (1392) | type I modular polyketide synthase |
M. marinum M | MMAR_3025 | pks12 | 0.0 | 45.23% (3111) | polyketide synthase, Pks12 |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb2074c | pks12 | 0.0 | 45.68% (3087) | polyketide synthase pks12 |
M. gilvum PYR-GCK | Mflv_0405 | - | 0.0 | 34.97% (3048) | beta-ketoacyl synthase |
M. tuberculosis H37Rv | Rv2048c | pks12 | 0.0 | 45.51% (3087) | polyketide synthase pks12 |
M. leprae Br4923 | MLBr_00135 | - | 0.0 | 45.54% (2130) | putative polyketide synthase |
M. abscessus ATCC 19977 | MAB_0939 | - | 0.0 | 34.08% (3072) | polyketide synthase |
M. avium 104 | MAV_2450 | - | 0.0 | 45.79% (3097) | erythronolide synthase, modules 3 and 4 |
M. smegmatis MC2 155 | MSMEG_0408 | - | 0.0 | 34.08% (3055) | type I modular polyketide synthase |
M. thermoresistible (build 8) | TH_2454 | - | 0.0 | 32.93% (1831) | PUTATIVE beta-ketoacyl synthase |
M. ulcerans Agy99 | MUL_2266 | pks12 | 0.0 | 45.49% (3073) | polyketide synthase, Pks12 |
M. vanbaalenii PYR-1 | Mvan_1003 | - | 0.0 | 35.00% (3037) | beta-ketoacyl synthase |
CLUSTAL 2.0.9 multiple sequence alignment Mb2074c|M.bovis_AF2122/97 -MVDQLQHATEALRKALVQVERLKRTNRALLERSSEPIAIVGMSCRFPGG Rv2048c|M.tuberculosis_H37Rv -MVDQLQHATEALRKALVQVERLKRTNRALLERSSEPIAIVGMSCRFPGG MUL_2266|M.ulcerans_Agy99 -MVDQLQHATEALRKALVQVERLKRTKRALLERSSEPIAIVGMSCRFPGG MAV_2450|M.avium_104 MMVDQLQHATEALRKALVQVERLKRTNRALLERSSEPIAIVGMSCRFPGG MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MMAR_3798|M.marinum_M --MENEERLRKYLQKAANDLRKSNKRVRELERRTVEPVAVVGMACRFPGG Mflv_0405|M.gilvum_PYR-GCK -----------------------MGSAAHQGE-SAHRFAIVGYAGRFPG- MAB_0939|M.abscessus_ATCC_1997 -----------------------MDSAENPIE-STPRFAIIGYAARFPG- MSMEG_0408|M.smegmatis_MC2_155 -----------------------MVSAEHPIE-PTPSFAIIGYAARFPG- Mvan_1003|M.vanbaalenii_PYR-1 ---------MTDLQKRALQAIEVLRARVRELEGAGDGYAIVGYALRFPG- TH_2454|M.thermoresistible__bu -------------------------------------------------- Mb2074c|M.bovis_AF2122/97 VDSPEGLWQMVADARDVMSEFPTDRGWDLAGLFDPDPDVRHKSYARTGGF Rv2048c|M.tuberculosis_H37Rv VDSPEGLWQMVADARDVMSEFPTDRGWDLAGLFDPDPDVRHKSYARTGGF MUL_2266|M.ulcerans_Agy99 VDSPEGLWQMVAEGRDVMSDFPTDRGWDLADLFDPDPDTPHKSYASTGGF MAV_2450|M.avium_104 VDSPEALWQMVAEGRDVISEFPTDRGWDLAALYDPDPDARHKCYVNTGGF MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MMAR_3798|M.marinum_M ADSPDGLWQMVSEGRDVLSEFPSDRGWDLGGLYDPEPDRVGYVHARAGGF Mflv_0405|M.gilvum_PYR-GCK ARDAESFWELLADGRDAISEVPEDR-WDVEAFFDPDPSTPGKVVTRRAGF MAB_0939|M.abscessus_ATCC_1997 AADAEEFWDVLREGRDAISEVPADR-WDAEEFFDPEPGAPGKVVTRRAGF MSMEG_0408|M.smegmatis_MC2_155 AASAEEYWALLRDGREAISDVPKDR-WDIEEFFDPDPSTPGKVVTRRAGF Mvan_1003|M.vanbaalenii_PYR-1 AADADEFWDVLRGGRDAISEVPQDR-WDADEFFDADPEAAGKMVTRRAGF TH_2454|M.thermoresistible__bu -------------------------------------------------- Mb2074c|M.bovis_AF2122/97 VDGVADFDPAFFGISPSEALAMDPQHRMLLELSWEALERAGIDPTGLRGS Rv2048c|M.tuberculosis_H37Rv VDGVADFDPAFFGISPSEALAMDPQHRMLLELSWEALERAGIDPTGLRGS MUL_2266|M.ulcerans_Agy99 VDGVADFDPGFFGIAPSEALAMDPQHRMLLELSWEALERSGIDPTGLRGS MAV_2450|M.avium_104 VDNVADFDPAFFGIAPSEALAMDPQHRMLLELSWEALERAGIDPSGLRGS MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MMAR_3798|M.marinum_M LDGVADFDAGFFGISPREALGMDPQQRLILEIAWETLESASIDPQSLRGS Mflv_0405|M.gilvum_PYR-GCK VDDVSGFDAPFFGMSTREVRLMDPQHRLLLETAWRAIEHSGTAPSELANT MAB_0939|M.abscessus_ATCC_1997 VEDVTGFDAPFFGMSTREVRLMDPQHRLLLETAWRAVEHSGIAPTDLAET MSMEG_0408|M.smegmatis_MC2_155 VDDVTGFDAPFFGMSAREVRLMDPQHRILMETAWRAVEHSGIAPTSLANS Mvan_1003|M.vanbaalenii_PYR-1 VEDVAGFDAPFFGVSAREAMFMDPQHRLLLETAWRAVEHSGTAPSALAGT TH_2454|M.thermoresistible__bu -------------------------------------------------- Mb2074c|M.bovis_AF2122/97 ATGVFAGLIVGGYG------MLAEEIEGYRLTGMTSSVASGRVAYVLGLE Rv2048c|M.tuberculosis_H37Rv ATGVFAGLIVGGYG------MLAEEIEGYRLTGMTSSVASGRVAYVLGLE MUL_2266|M.ulcerans_Agy99 ATGVFAGLIVQGYG------MFAEEIEGYRLTGMTSSVASGRVAYVLGLE MAV_2450|M.avium_104 ATGVFAGLIVQGYG------MLAEEIEGYRLTGMTSSVASGRVSYVLGLE MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MMAR_3798|M.marinum_M QTGVFAGTMTSCYG------VGIDNVT---------SAVSGRVAYAFGFE Mflv_0405|M.gilvum_PYR-GCK NTGVFVGLATHDYLGMASDELSYPEIEAYMAIGTSNAAAAGRISYRLGLQ MAB_0939|M.abscessus_ATCC_1997 NSGVFVGLATHDYLGMASDELTFPEIEAYMAIGTSNAAAAGRISYRLGLQ MSMEG_0408|M.smegmatis_MC2_155 NTGVFVGLATHDYLGMASDELTYPEIEAYMAIGTSNAAAAGRISYRLGLQ Mvan_1003|M.vanbaalenii_PYR-1 RTGVFMGLSTHDYLGMLTDNLTHDAIEAYLGTGTSPAAAIGRISYRLGLQ TH_2454|M.thermoresistible__bu -------------------------------------------------- Mb2074c|M.bovis_AF2122/97 GPAVSVDTACSSSLVALHMAVGSLRSGECDLALAGGVTVNATPTVFVEFS Rv2048c|M.tuberculosis_H37Rv GPAVSVDTACSSSLVALHMAVGSLRSGECDLALAGGVTVNATPTVFVEFS MUL_2266|M.ulcerans_Agy99 GPAVSVDTACSSSLVALHMAVQSLRSGECDLALAGGATVNATPTVFVEFS MAV_2450|M.avium_104 GPAVSVDTACSSSLVALHMAVQSLRSGECDLALAGGATVNATPTVFVEFS MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MMAR_3798|M.marinum_M GPAVTVDTACSSSLVAIHQACQSLRGGECSMALAGGVTVMATPDVFAEFA Mflv_0405|M.gilvum_PYR-GCK GPAVAVDTACSSSLVAIHQACQALRLGECDLALAGGANVILTPATMITFS MAB_0939|M.abscessus_ATCC_1997 GPSVAVDTACSSSLVAIHQACQALQLGECDLALAGGANVLLTPATMITFS MSMEG_0408|M.smegmatis_MC2_155 GPAVAVDTACSSSLVAIHQACQALRLNECDLALAGGANVLLTPATMITFS Mvan_1003|M.vanbaalenii_PYR-1 GPAVAVDTACSSSLVAVHQACQALRLAECDVALAGGVNVLLSPATMINFS TH_2454|M.thermoresistible__bu -------------------------------------------------- Mb2074c|M.bovis_AF2122/97 RHRGLAPDGRCKPYAGRADGVGWSEGGGMLVLQRLSDARRLGHPVLAVVV Rv2048c|M.tuberculosis_H37Rv RHRGLAPDGRCKPYAGRADGVGWSEGGGMLVLQRLSDARRLGHPVLAVVV MUL_2266|M.ulcerans_Agy99 RHRGLAPDGRSKAYAGAADGVGWSEGGAMLVVERLSDAQRLGHPVLALVR MAV_2450|M.avium_104 RHRGLAPDGRCKAYAGAADGVGWSEGGAMLVVERLSDARRLGHPVLAVVR MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MMAR_3798|M.marinum_M RQRGLSADGRCKAFAASADGTGFGEGAGLVLLERLSDARRNRHPVLAVIR Mflv_0405|M.gilvum_PYR-GCK NAHMLAPDGRCKTFDAAADGYVRGEGCGVIVIKRLEDAVRDGDRIRAVIR MAB_0939|M.abscessus_ATCC_1997 HAHMLAPDGKCKTFDAAADGYVRGEGSGVIVIKRLEDAIRDGDRIRAVIR MSMEG_0408|M.smegmatis_MC2_155 NAHMLAPDGRCKTFDAAADGYVRGEGCGVVVVKRLEDAVRDGDRIRAVIR Mvan_1003|M.vanbaalenii_PYR-1 RARMLAPDGRCKTFDATADGYVRGEGCGVVVVKRLADAIRHGDRIRAVIR TH_2454|M.thermoresistible__bu -------------------------------------------------- Mb2074c|M.bovis_AF2122/97 GSAVNQDGASNGLTAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTT Rv2048c|M.tuberculosis_H37Rv GSAVNQDGASNGLTAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTT MUL_2266|M.ulcerans_Agy99 GSAVNQDGASNGLTAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTT MAV_2450|M.avium_104 GSAVNQDGASNGLTAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTT MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MMAR_3798|M.marinum_M GSAVNQDGASNGLTAPNGPAQERVIRSAVAAAGLRVADVDVVEAHGTGTT Mflv_0405|M.gilvum_PYR-GCK GSAINQDGASGGLTVPNGVAQQRVIGDALSRAGLAPGDVDYLEAHGTGTS MAB_0939|M.abscessus_ATCC_1997 GSAINQDGASGGLTVPNGVAQQRVIADALKRAGVAPSEVGYLEAHGTGTS MSMEG_0408|M.smegmatis_MC2_155 GSAINQDGASGGLTVPNGVAQQRVIADALKRAGLRPADVGYLEAHGTGTS Mvan_1003|M.vanbaalenii_PYR-1 GSAVNQDGASGGLTVPNGAAQQRVIADALTNAGLTAADVDYLEAHGTGTP TH_2454|M.thermoresistible__bu -------------------------------------------------- Mb2074c|M.bovis_AF2122/97 LGDPIEAQALLATYGQDRGEP---GEPLWLGSVKSNMGHTQAAAGVAGVI Rv2048c|M.tuberculosis_H37Rv LGDPIEAQALLATYGQDRGEP---GEPLWLGSVKSNMGHTQAAAGVAGVI MUL_2266|M.ulcerans_Agy99 LGDPIEAQALLATYGQDRGSAGAAGKALWLGSIKSNMGHTQAAAGVAGVI MAV_2450|M.avium_104 LGDPIEAQALLATYGQDRGQP------LWLGSIKSNMGHTQAAAGVAGVI MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MMAR_3798|M.marinum_M LGDPIEAHALLATYGADRDAEQP----LWLGSVKSNMGHTQAAAGVAGLI Mflv_0405|M.gilvum_PYR-GCK LGDPIEAQAAGAALGPGREPQRP----LLIGSAKTNIGHLEAAAGIAGVI MAB_0939|M.abscessus_ATCC_1997 LGDPIEAQAAGAAYGIGRETNDP----LLIGSAKTNIGHLEAAAGIAGVI MSMEG_0408|M.smegmatis_MC2_155 LGDPIEAQAAGEVLGAGRAPEEP----LLIGSAKTNIGHLEAAAGIAGVI Mvan_1003|M.vanbaalenii_PYR-1 LGDPIEVQAAGAVLGVGREPDRP----LLIGSVKTNIGHLEAASGIAGLL TH_2454|M.thermoresistible__bu -------------------------------------------------- Mb2074c|M.bovis_AF2122/97 KMVLAMRHELLPATLHVDVPSPHVDWSAGAVELLTAPRVWP---AGARTR Rv2048c|M.tuberculosis_H37Rv KMVLAMRHELLPATLHVDVPSPHVDWSAGAVELLTAPRVWP---AGARTR MUL_2266|M.ulcerans_Agy99 KMVQAMRHEVLPATLHVDVPSPHVDWSAGAVELLTEAQPWPAESAGDRVR MAV_2450|M.avium_104 KMVLAMRHELLPATLHVDEPSPHVDWSAGAVSLLTEAQPWP----GERPR MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MMAR_3798|M.marinum_M KMIQAINHAVLPPTLHVDAPSPHIDWSAGAVRLLTEAVPWP---DTGRAR Mflv_0405|M.gilvum_PYR-GCK KVVLSLEHETLPKHLNFENPSPHIPWDRLPVEVVKESIPWRRGQRGGRPR MAB_0939|M.abscessus_ATCC_1997 KVILSLENELLPQHRNFQNPSPHIPWDRLPVEVVREARPWGR---NGRPR MSMEG_0408|M.smegmatis_MC2_155 KVVMALENETLPKHLNFETPSPHIPWERLPIEVVRETVPWQR---NGKPR Mvan_1003|M.vanbaalenii_PYR-1 KVILSLEHQVLPKHLNFRSPSPHIPWNRLPVRIVDDPVPWTR---SGRSR TH_2454|M.thermoresistible__bu -------------------------------------------------- Mb2074c|M.bovis_AF2122/97 RAGVSSFGISGTNAHVIIEAVP---VVPRR-EAGWAGP-VVPWVVSAKSE Rv2048c|M.tuberculosis_H37Rv RAGVSSFGISGTNAHVIIEAVP---VVPRR-EAGWAGP-VVPWVVSAKSE MUL_2266|M.ulcerans_Agy99 RAGVSSFGISGTNAHVIVEAAP---RVEVGGSSGGAVP-VVPWVVSAKSG MAV_2450|M.avium_104 RAGVSSFGISGTNAHVIIEAVP---AVEPAHADAPALP-VLPWVVSAKSA MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MMAR_3798|M.marinum_M TAGISSFGISGTNAHLIAQEAPQESTADPSPSDVCEPL-FRVWPVSGRTA Mflv_0405|M.gilvum_PYR-GCK IAGVSSFGFAGTNAHVILEEAPLAAEPAQES---VDDGRFTLLPLSARTP MAB_0939|M.abscessus_ATCC_1997 IAGVSSFGFAGTNAHVILEEAPVVSRDAVEPPAPAGGRKFSILPLSARTP MSMEG_0408|M.smegmatis_MC2_155 IAGVSSFGFAGTNAHVILEEAPAVGTPATTEP-VEDPRRYSVLPLSARTP Mvan_1003|M.vanbaalenii_PYR-1 VAGISSFGFSGTNAHVLVEEAPRADRAGAAPQ-PAAPGGFGMLPLSARTP TH_2454|M.thermoresistible__bu -------------------------------------------------- Mb2074c|M.bovis_AF2122/97 SALRGQAARLAAYVRGDDGLDVADVGWSLAG-RSVFEHRAVVVGG----- Rv2048c|M.tuberculosis_H37Rv SALRGQAARLAAYVRGDDGLDVADVGWSLAG-RSVFEHRAVVVGG----- MUL_2266|M.ulcerans_Agy99 SALGAQAARLAAHVRSHDELDVADVGWSLAG-RSTFEHRAVVLGA----- MAV_2450|M.avium_104 AALRAQAARLAEYVRAQGELDIADVGWTLAG-RATFEHRAVVVGG----- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MMAR_3798|M.marinum_M EALNAQAERLGQYLVDHPDLDLTDLAYSLATTRAHHAYRAAVTVPGDTVN Mflv_0405|M.gilvum_PYR-GCK AALMAVADRYRDWLVANPDATLADLCFTAGTARSHLEHRAALVVN----- MAB_0939|M.abscessus_ATCC_1997 AALAQLADKYRAWLNAHPEAALADLCFTAGVGRAHLEHRAALVVN----- MSMEG_0408|M.smegmatis_MC2_155 EALVRLAGEYRDWLRAHPQARLADVSHTAGTARAHLEQRAALVVN----- Mvan_1003|M.vanbaalenii_PYR-1 DALAATAHRLRTWLAANPDASWPDLCFTAAVGRSHLRHRAALVVD----- TH_2454|M.thermoresistible__bu -------------------------------------------------- Mb2074c|M.bovis_AF2122/97 DRDRLLAGLDELAGDQLG-GSVVRGTAT-AAGKTVFVFPGQGSQWLGMGI Rv2048c|M.tuberculosis_H37Rv DRDRLLAGLDELAGDQLG-GSVVRGTAT-AAGKTVFVFPGQGSQWLGMGI MUL_2266|M.ulcerans_Agy99 DRDGLLAGLDELAGDEFGGASVIRGVAG-AAGKTVFVFPGQGSQWIGMGI MAV_2450|M.avium_104 DRDRLLAGLDELAADDPA-ASIIRGVAT-PAGKTVFVFPGQGSQWLGMAT MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MMAR_3798|M.marinum_M TRDDLLAGLRSLAVDQFHPGVTYHHYRLGQAGKTVFVFPGQGAQYAGMGA Mflv_0405|M.gilvum_PYR-GCK TREAALDLLGALADDRPAPGLVRGESHD--TPKTAWLFTGQGSQYPGMSR MAB_0939|M.abscessus_ATCC_1997 TREAAVELLSAVADDRPAPGLGRGESHD--TPKTAWLFTGQGSQYPGMAR MSMEG_0408|M.smegmatis_MC2_155 SRESAIELLGALADDRPAPGLVRGESHE--APKTAWLFTGQGSQYPGMAR Mvan_1003|M.vanbaalenii_PYR-1 SRSSVEELLGALAEDRPGPGLARGECGD--PPKTAWLFTGQGSQYPGMGR TH_2454|M.thermoresistible__bu -------------------------------------------------- Mb2074c|M.bovis_AF2122/97 ELLDTAPAFAQQIDACAEAFAEFVDWSLVDVLRGAPGA------PGLDRV Rv2048c|M.tuberculosis_H37Rv ELLDTAPAFAQQIDACAEAFAEFVDWSLVDVLRGAPGA------PGLDRV MUL_2266|M.ulcerans_Agy99 ELLDTAPVFARHIESCGQAFAEFVDWSLLDVLRGAAGA------PGLDRI MAV_2450|M.avium_104 ELLDTAPVFAQHIQACEEAFAEFVDWSLIDALRGAPGA------AGMDRV MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MMAR_3798|M.marinum_M GLYRHHPVFTTAIDEICAVMDEHLDVPLRDVMFTEPG--------LLQQT Mflv_0405|M.gilvum_PYR-GCK ELFDTEPLFAETLRECAAAVDGMLEKPLLDVIFDTDGVLDTDSNETLRHT MAB_0939|M.abscessus_ATCC_1997 ELFETEPVFADTLNRCAAAVADVLEKPLLDVIFDVD---GPEAEETLRQT MSMEG_0408|M.smegmatis_MC2_155 ELFDTEPVFAETVRKCAEAVADILEKPLLDVIFDAD-ELDGDTESPLRHT Mvan_1003|M.vanbaalenii_PYR-1 ELFDTEPVYREVMTRCAEAVADVLERPLLDVVFDAD------GGEALRHT TH_2454|M.thermoresistible__bu -------------------------------------------------- Mb2074c|M.bovis_AF2122/97 DVVQPVLFAVMVSLAELWKSVAVHPDAVIGHSQGEIAAAYVAGALSLRDA Rv2048c|M.tuberculosis_H37Rv DVVQPVLFAVMVSLAELWKSVAVHPDAVIGHSQGEIAAAYVAGALSLRDA MUL_2266|M.ulcerans_Agy99 DVVQPVLFAVMVSLAELWKSVGVRPDAVIGHSQGEIAAAYVAGALSLRDA MAV_2450|M.avium_104 DVVQPALFAVMVSLAELWKSVGVSPDAVIGHSQGEIAAAYVAGALSLRDA MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MMAR_3798|M.marinum_M VYAQPALFAFGVAMHAVLTQAGVNPDYLLGHSVGELTAAHVAGVLSLEEA Mflv_0405|M.gilvum_PYR-GCK SYAQPALFAVEMGLARLWQSWGFEPDVVLGHSVGQYAAACVAGVLSLRDG MAB_0939|M.abscessus_ATCC_1997 SYAQPALFAVEMGLARLWQSWGFEPDVVLGHSVGQYSAACVAEVFSLEDG MSMEG_0408|M.smegmatis_MC2_155 TYAQPALFAVELGLARLWQSWGFEPDVVVGHSVGQYSAACVAGVFDVEDG Mvan_1003|M.vanbaalenii_PYR-1 SYAQPALYAVEMGLARLWQSWGIEPDVVLGHSVGQYAAACVAGVMGLEDG TH_2454|M.thermoresistible__bu -------------------------------------------------- Mb2074c|M.bovis_AF2122/97 ARVVTLRSKLLAGLAGPGGMVSIACGADQARDLLAPFGDRVSIAVVNGPS Rv2048c|M.tuberculosis_H37Rv ARVVTLRSKLLAGLAGPGGMVSIACGADQARDLLAPFGDRVSIAVVNGPS MUL_2266|M.ulcerans_Agy99 AKVVTLRSKLLVGLAGPGGMVSVACGEQQARELLEPFGDRVSIAAINGPS MAV_2450|M.avium_104 ARVVTLRSKLLRSLAGPGGMLSIACSTERARELLAPYGNRVSIAAVNGRS MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MMAR_3798|M.marinum_M AVLVCARGRLMQSCT-PGAMMAISASEPAVAAMLENHP-EVVIAAVNGPT Mflv_0405|M.gilvum_PYR-GCK ARLMAERGRLFGSLPSGGRMAAVFAAAERVEALTDEYPALSVAAYNG--A MAB_0939|M.abscessus_ATCC_1997 ARLIAERGRLFSSLPAGGRMAAVFTDAERAERLTDEFPSLSVAAYNG--A MSMEG_0408|M.smegmatis_MC2_155 ARLIAERGRLFGSLPAGGRMAAVFTAPERAERLTDEYPSLSVAAYNG--A Mvan_1003|M.vanbaalenii_PYR-1 AVLLAERGRLFGSLPEGGRMAAVFAPADRVESCTVDSPLLSVAAYNG--D TH_2454|M.thermoresistible__bu -------------------------------------------------- Mb2074c|M.bovis_AF2122/97 AVVVSGEVGALEELIAVCSTKELRTRRIEVDYASHSVEVEAIRGPLAEAL Rv2048c|M.tuberculosis_H37Rv AVVVSGEVGALEELIAVCSTKELRTRRIEVDYASHSVEVEAIRGPLAEAL MUL_2266|M.ulcerans_Agy99 AVVVSGEVAALEELIAQCADRELRTRRIDVDYASHSVEVEAIEGQLTEVL MAV_2450|M.avium_104 AVVVSGEGAALDELAAFCADLALRTRRIDVDYASHSVEVEAIREDLAQAL MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MMAR_3798|M.marinum_M SVAVAGPAEQLNALREHCNISNHKVTLLRVSHAFHSPAMDPILAEFEAIA Mflv_0405|M.gilvum_PYR-GCK NTVLSGPATDLERAVAGLVADGVRCDWLETSHAFHSALLDPILDDFESYA MAB_0939|M.abscessus_ATCC_1997 NTVLSGPAQDLEKAIAALVADGVRCDFLETSHAFHSALLDPILDEFEAYA MSMEG_0408|M.smegmatis_MC2_155 NTVLSGPAKDLESAVATLVADGVRCDWLDTSHAFHSALLDPILDDFESFA Mvan_1003|M.vanbaalenii_PYR-1 NTVLSGPAGDLERAVAGFSAAGVRCDWLDTSHAFHSALLDPVLEEFESCA TH_2454|M.thermoresistible__bu -------------------------------------------------- Mb2074c|M.bovis_AF2122/97 SGIEPRSTRTVFFSTVTGNRLDTAGLD-ADYWYRNVRQTVLFDQAVRNAC Rv2048c|M.tuberculosis_H37Rv SGIEPRSTRTVFFSTVTGNRLDTAGLD-ADYWYRNVRQTVLFDQAVRNAC MUL_2266|M.ulcerans_Agy99 AGIEPLSSRTAFFSSVTGSRLDTAELD-AEYWYRNIRQTVQFDQAVRSAC MAV_2450|M.avium_104 TGIEPRSSRIAFFSTVTGNRLDTAGLD-ADYWYRNIRQTVQFDQTVRSAA MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MMAR_3798|M.marinum_M KRLTYRPHSVPIMSNLTGSLATVEQLTSARYWAQHLRKPVRFYDGVTRLL Mflv_0405|M.gilvum_PYR-GCK RGITFTAPQRILIDNRTGAALGRSVTLDAAYWRRHARQPVEFAKSVHTLA MAB_0939|M.abscessus_ATCC_1997 NQFNYKTPQRILIDNRTGTALGRSVKLDGAYWRRHARQPVEFAKSVRTLA MSMEG_0408|M.smegmatis_MC2_155 QKLEYREPQRILIDNRTGSALGRSTRLDGAYWRRHARQPVEFAKSVRTLA Mvan_1003|M.vanbaalenii_PYR-1 DRFEFGTPQRTLVCNRSGEVLSRHARLDGQYWRRHARQPVRFAESVRTLA TH_2454|M.thermoresistible__bu -------------------------------------------------- Mb2074c|M.bovis_AF2122/97 EQGYRTFIESSPHPALITGVEETFAACTDGD-SEAIVVPTLGRGDGGLHR Rv2048c|M.tuberculosis_H37Rv EQGYRTFIESSPHPALITGVEETFAACTDGD-SEAIVVPTLGRGDGGLHR MUL_2266|M.ulcerans_Agy99 GHGYRTFIESSPHPALIAGIEDTYRNCAADSGADPIVVPTLGREDGGLQR MAV_2450|M.avium_104 EHGYRTFIESSPHPALVAGIEDTVNDSLPGD-TEAIVIPTLGRDDGGLER MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MMAR_3798|M.marinum_M AGGEQAFVELSPHPVLAAAITDTLTG--VTDRVGSAVVTTLRRDRPDMDM Mflv_0405|M.gilvum_PYR-GCK DMNCKLLVEIGPRPVLTAAALSAWPDPATSP----RVIASLRRTTADQRQ MAB_0939|M.abscessus_ATCC_1997 DMNCKVLLEIGPQPVLTAAALRAWPDPATAP----RAIASLRRNTADHRQ MSMEG_0408|M.smegmatis_MC2_155 DMNCRVLLEIGPRPVLTATALAAWPDPATTP----QVLASLRPTTADHRQ Mvan_1003|M.vanbaalenii_PYR-1 DLGCRLLMEIGPQPVLTAAAMRTWPGTVTAP----RVAASMRRKGSDRRQ TH_2454|M.thermoresistible__bu -------------------------------------------------- Mb2074c|M.bovis_AF2122/97 FLLSAASAFVAGVAVNWRGTLDG-AGYVELPTYAFDKRRFWLSAEGSGAD Rv2048c|M.tuberculosis_H37Rv FLLSAASAFVAGVAVNWRGTLDG-AGYVELPTYAFDKRRFWLSAEGSGAD MUL_2266|M.ulcerans_Agy99 FLASAAAAFVAGVNVDWRGPLDG-AGLVELPTYAFEKRRFWLSGEGVSVD MAV_2450|M.avium_104 FLTSAATAFVAGVNVAWRGVLDG-AGFVELPTYAFDRRRFWLSGEGAAAD MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MMAR_3798|M.marinum_M VASAIANLHVHGHSPSWQKIYPG-ATTVELPTYPFQHRRYWLDP-APRAD Mflv_0405|M.gilvum_PYR-GCK ITEAVADAYVLGHLPRFAAFRRDGARVLDLPTYPFEHRQYWFSDSRE--- MAB_0939|M.abscessus_ATCC_1997 ITEAAADAYVLGHLPDFGAFQHAPARKLDLPTYPFERRQYWFSDKRDGDN MSMEG_0408|M.smegmatis_MC2_155 ITEAVAAAYAAGHLPDFRAFRQPDARKLDLPTYPFEHRQFWFSDNRAIDR Mvan_1003|M.vanbaalenii_PYR-1 ITEALAQAYVAGHRPETAARQHGRGRLLDLPTYPFQHRAYWFP------- TH_2454|M.thermoresistible__bu -------------------------------------------------- Mb2074c|M.bovis_AF2122/97 VSGLGLGASEHPLLGAVVDLPASGGVVLTGRLSPNVQPWLADHAVSDVVL Rv2048c|M.tuberculosis_H37Rv VSGLGLGASEHPLLGAVVDLPASGGVVLTGRLSPNVQPWLADHAVSDVVL MUL_2266|M.ulcerans_Agy99 ASGLGLSAGGHALLGAVVELPESGGVVLTGRLALGAHGWLADHAVSGVVV MAV_2450|M.avium_104 ASGLGLGTSEHPLLSAVVELPASGGVVLTGRLSPSLQGWLTDHAVSGTVV MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MMAR_3798|M.marinum_M VSAAGLDQPEHPLLAAVTELADQDQIVLSGRLSTSAHRWLAGHQLGDTVV Mflv_0405|M.gilvum_PYR-GCK PVAAAPQR---GARTETVRLLEDGRIEELAALLG---------------- MAB_0939|M.abscessus_ATCC_1997 RDAGNRQQNNGGPRTEAVRLLEDGKIEELANLLG---------------- MSMEG_0408|M.smegmatis_MC2_155 DTQTASAGSVTPHRTQAVRLLEDGQIEELAALID---------------- Mvan_1003|M.vanbaalenii_PYR-1 -QGQARTAPTDPVHTETVRFLDEERIDELAALLD---------------- TH_2454|M.thermoresistible__bu -------------------------------------------------- Mb2074c|M.bovis_AF2122/97 FPGTGFVELAIRAGDEVGCSVLDELTLAAPLLLPAT----GSVAVQVVVD Rv2048c|M.tuberculosis_H37Rv FPGTGFVELAIRAGDEVGCSVLDELTLAAPLLLPAT----GSVAVQVVVD MUL_2266|M.ulcerans_Agy99 FPGTGFVELAIRAVDEVGCSVVNELTLRTPLVLPAS----GSVAVQVVVG MAV_2450|M.avium_104 FPGAGFVELAIRAGDEVGCSTVEELTLQAPLMLPAKDSGIGSVAVQVLVG MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MMAR_3798|M.marinum_M LPATALIDMALYAGEHTGCPTIDELVLQTPLTLTPD----AATDLQISVA Mflv_0405|M.gilvum_PYR-GCK -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_1003|M.vanbaalenii_PYR-1 -------------------------------------------------- TH_2454|M.thermoresistible__bu -------------------------------------------------- Mb2074c|M.bovis_AF2122/97 AGRDSNSRGVSIFSRADAQAG------WLLHAEGILRPGSVEPGADLSVW Rv2048c|M.tuberculosis_H37Rv AGRDSNSRGVSIFSRADAQAG------WLLHAEGILRPGSVEPGADLSVW MUL_2266|M.ulcerans_Agy99 AAADSAERSVSIYSRTDTDTDTDAGSVWVCHAEGTLGADSAQPAADLSAW MAV_2450|M.avium_104 EADESGRRDVSIFSRPDSDSP------WVCHAQGTLSTGSIEPGADLAAW MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MMAR_3798|M.marinum_M APDEQNRRTFSVHARTSEHPHQHS--TWVLHASGTLSNAPSTTPPTKPLP Mflv_0405|M.gilvum_PYR-GCK -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_1003|M.vanbaalenii_PYR-1 -------------------------------------------------- TH_2454|M.thermoresistible__bu -------------------------------------------------- Mb2074c|M.bovis_AF2122/97 PPAGAVTVDVADGYERLATRGYRYGPAFRGLTAMWAR---GEEIFAEVRL Rv2048c|M.tuberculosis_H37Rv PPAGAVTVDVADGYERLATRGYRYGPAFRGLTAMWAR---GEEIFAEVRL MUL_2266|M.ulcerans_Agy99 PPAGAIAVDVADGYERLDARGYGYGPAFRGLTAMWAR---GEELFAEARL MAV_2450|M.avium_104 PPAGATKVDIADGYQRLAARGYGYGPAFQGLTAAWVR---GDEVFAEVRL MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MMAR_3798|M.marinum_M GPQAITKVNQESFYDQLAQHGLHYSEAFRSIQGIGKDPLNPDAICAEVAL Mflv_0405|M.gilvum_PYR-GCK -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_1003|M.vanbaalenii_PYR-1 -------------------------------------------------- TH_2454|M.thermoresistible__bu -------------------------------------------------- Mb2074c|M.bovis_AF2122/97 PEAAGGVGGFGVHPALLDAVLHAVVI----AGDPDELALPFAWQGVSLHA Rv2048c|M.tuberculosis_H37Rv PEAAGGVGGFGVHPALLDAVLHAVVI----AGDPDELALPFAWQGVSLHA MUL_2266|M.ulcerans_Agy99 PEAAGSTSGFGVHPALLDAALHTAVI----ANPDADLVLPFSWQGVSLHA MAV_2450|M.avium_104 PDAAGGVTGFGVHPALLDAAMHALIVGHQIAGDTDEVALPFAWQGVSLHA MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MMAR_3798|M.marinum_M PADIETHG-YGIHPALLDAALHPLTAALADTNTNSGPQLPFAIAGITLHA Mflv_0405|M.gilvum_PYR-GCK -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_1003|M.vanbaalenii_PYR-1 -------------------------------------------------- TH_2454|M.thermoresistible__bu -------------------------------------------------- Mb2074c|M.bovis_AF2122/97 TGASAVRARIAPAGPS------AVSVELADGLGLPVLSVASMVARPVTER Rv2048c|M.tuberculosis_H37Rv TGASAVRARIAPAGPS------AVSVELADGLGLPVLSVASMVARPVTER MUL_2266|M.ulcerans_Agy99 AGAASVRVRIAPVGPS------SVSVELADDLGLPVLSVKAMVARPVSEQ MAV_2450|M.avium_104 AGASAVRARLAPAQAPGTAASRAVSLELADGLGLPVLSVRAMVARSVSER MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MMAR_3798|M.marinum_M TGASRMHVQLEPTATD------TFRLSATDPVGAPVITIDSLTVRSLPDT Mflv_0405|M.gilvum_PYR-GCK --------------------------------GTVDDPFTFDVLNRLAAQ MAB_0939|M.abscessus_ATCC_1997 --------------------------------GVDGDQQTLNVLTKLAAQ MSMEG_0408|M.smegmatis_MC2_155 --------------------------------GETVDEQTLRVLNKLAAR Mvan_1003|M.vanbaalenii_PYR-1 --------------------------------GPTGSAQTVDVLSKLAAR TH_2454|M.thermoresistible__bu -------------------------------------------------- Mb2074c|M.bovis_AF2122/97 QLLAAVSGSGPDRLFEVIWSPA---------------------------- Rv2048c|M.tuberculosis_H37Rv QLLAAVSGSGPDRLFEVIWSPA---------------------------- MUL_2266|M.ulcerans_Agy99 QMRAVVSASGPDRLFEVVWTPM---------------------------- MAV_2450|M.avium_104 QLRAAVSAAGPDRLFEVAWAPV---------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MMAR_3798|M.marinum_M DLTQPPTHKAQQGIFELTWPALPAETFPATGVLPPWALISPHPENLSPDL Mflv_0405|M.gilvum_PYR-GCK HNQQRSTESIADDRYQIRWETA---------------------------- MAB_0939|M.abscessus_ATCC_1997 HNLQRTTQTIADDRYQFRWEKS---------------------------- MSMEG_0408|M.smegmatis_MC2_155 HNQQRSTHVDPDARYEIRWDAI---------------------------- Mvan_1003|M.vanbaalenii_PYR-1 HRQQRGAQSIADARYQIRWEKS---------------------------- TH_2454|M.thermoresistible__bu -------------------------------------------------- Mb2074c|M.bovis_AF2122/97 ---------SAATSPGPTPAYQIFESVAADQDPVAGSYVRSHQALAAVQS Rv2048c|M.tuberculosis_H37Rv ---------SAATSPGPTPAYQIFESVAADQDPVAGSYVRSHQALAAVQS MUL_2266|M.ulcerans_Agy99 ---------TVAAT-DAAPAYELFESIAADGDPLSGTYQRTHQALAAVQS MAV_2450|M.avium_104 ---------TVPAAHGEPPVHQVFESLAAEGDPVGESYRRTHEALAAVQS MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MMAR_3798|M.marinum_M NQSPTYPNLTALPTCPPLVIWDLTTPQPPQSDLLHQVHTLTQHTLAGLQN Mflv_0405|M.gilvum_PYR-GCK -----------------------------------AEPPVGADAADGITW MAB_0939|M.abscessus_ATCC_1997 -----------------------------------PTPLSGSQAAGGVTW MSMEG_0408|M.smegmatis_MC2_155 -----------------------------------ASAAASTGAAA--DW Mvan_1003|M.vanbaalenii_PYR-1 -----------------------------------EAPGAARPTTEATTW TH_2454|M.thermoresistible__bu -------------------------------------------------- Mb2074c|M.bovis_AF2122/97 WLT--DHESGVLVVATRGAMALPREDVA-DLAGAAVWGLVRSAQTEHPGR Rv2048c|M.tuberculosis_H37Rv WLT--DHESGVLVVATRGAMALPREDVA-DLAGAAVWGLVRSAQTEHPGR MUL_2266|M.ulcerans_Agy99 WLT--EHDSGVLVVATRGAMALAGEDVT-DLAGAAVWGLVRSAQTENPGR MAV_2450|M.avium_104 WLT--EHDSGVLVVVTRGAMALAGEDVT-DLSGAAVWGLVRSAQTEHPGR MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MMAR_3798|M.marinum_M WLNRSDTLQAHLVVLTRHAVTTSPHDLAPDPAQAATAALIHTTQNEHPNR Mflv_0405|M.gilvum_PYR-GCK LLVGDDTDATRPLVDVLAARGHRYRILGLPKSGAEEHELADTLRDAAADA MAB_0939|M.abscessus_ATCC_1997 LLVADAAGAAQPLLDVLTARGQQHRVLALPVSDADEAELVEALRSAADED MSMEG_0408|M.smegmatis_MC2_155 ILVGDDTAAVLEFADALTAGGHRHQIVALPGSDADEAQLVDTLRAASAG- Mvan_1003|M.vanbaalenii_PYR-1 LLVTHDSRAAQPIAEVLERRGHPYHIVGLPGSDADAAPAEEALRATVSQ- TH_2454|M.thermoresistible__bu -------------------------------------------------- Mb2074c|M.bovis_AF2122/97 IVLVDSDAATDDAAIAM---------ALATGEPQVVLRGGQVYTARVRGS Rv2048c|M.tuberculosis_H37Rv IVLVDSDAATDDAAIAM---------ALATGEPQVVLRGGQVYTARVRGS MUL_2266|M.ulcerans_Agy99 LVLVDSDAAVDAAAVAT---------ALAVGEPQVVLRNGQPYTARVHAS MAV_2450|M.avium_104 IVLIDSDAALDDSALTA---------ALATGEPQVLLRDGTVYTARVHGS MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MMAR_3798|M.marinum_M ITLIDIDNTPTTSQTLTNILTTLTNPTSAPTEPQLALRHGTPHTPRLTP- Mflv_0405|M.gilvum_PYR-GCK TDLRIVHVAALDAAESD--------------------------------- MAB_0939|M.abscessus_ATCC_1997 SALRIVHVAALAGQGS---------------------------------- MSMEG_0408|M.smegmatis_MC2_155 -ELYVVHIAAGDGAAA---------------------------------- Mvan_1003|M.vanbaalenii_PYR-1 PRPHILYLAALEEPGG---------------------------------- TH_2454|M.thermoresistible__bu -------------------------------------------------- Mb2074c|M.bovis_AF2122/97 RAADAILVPPGDGPWRLGLGSAGTFENLRLEPVPNADAPLGPGQVRVAMR Rv2048c|M.tuberculosis_H37Rv RAADAILVPPGDGPWRLGLGSAGTFENLRLEPVPNADAPLGPGQVRVAMR MUL_2266|M.ulcerans_Agy99 RAADGILVPPVDGPWRLGLSSAGTFENLQLEPVPNAGAPLGPGQVRVAMR MAV_2450|M.avium_104 RAVDGIMTPPEDRPWRLGISSAGTFENLQLEPVPNPDAALQPGQVRVALR MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MMAR_3798|M.marinum_M ---TQVLTPPAAPNWELATTGKGDLANLALLPTP-PHTELGPGQIRVAVR Mflv_0405|M.gilvum_PYR-GCK ----------------TSMKSLLRMQHRVLGGTRRLFGAAVAAQLRSPMW MAB_0939|M.abscessus_ATCC_1997 ----------------SSAQSLLRIQHQVLGGTRRLFRAAAAAELRAPIW MSMEG_0408|M.smegmatis_MC2_155 -----------------PMRDLLRVQHRTLGGLRRLFRAANDAELRSPIW Mvan_1003|M.vanbaalenii_PYR-1 ----------------SAAETLGWMQHRVLAAARRLFQLAATAGARAPIW TH_2454|M.thermoresistible__bu -------------------------------------------------- Mb2074c|M.bovis_AF2122/97 AIAANFRDIMITLGMFTHDALLGGEGAGVVVEVGPGVTEFSVGDSVFGFF Rv2048c|M.tuberculosis_H37Rv AIAANFRDIMITLGMFTHDALLGGEGAGVVVEVGPGVTEFSVGDSVFGFF MUL_2266|M.ulcerans_Agy99 AIAANFRDIMITLGMFTHDALIGGEGAGVVVEIGPEVTEFAVGDAVYGFF MAV_2450|M.avium_104 AIATNFRDVMITLGMFTHDALLGGEGAGVVVEVGPGVTEFSVGDSVYGFF MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MMAR_3798|M.marinum_M AAGLNFRDVVVALGAIGEEG-LGGEAAGIIIDTGPDVTAFRRGDAVMGLF Mflv_0405|M.gilvum_PYR-GCK LVTR---------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 IVTR---------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 LVTR---------------------------------------------- Mvan_1003|M.vanbaalenii_PYR-1 LITA---------------------------------------------- TH_2454|M.thermoresistible__bu -------------------------------------------------- Mb2074c|M.bovis_AF2122/97 PD-GSGTLVAGDVRLLLPMPADWSYAEAAAISAVFTTAYYAFIHLADVQP Rv2048c|M.tuberculosis_H37Rv PD-GSGTLVAGDVRLLLPMPADWSYAEAAAISAVFTTAYYAFIHLADVQP MUL_2266|M.ulcerans_Agy99 PD-GSGTLVAGDVRLLLPKPADWSYAEAAAISAVFTTAYYAFVHLANVQP MAV_2450|M.avium_104 PD-GSGTLVPGDVRLLQHKPTHWSYPEAAGISAVFTTAYMAFIHLADVKP MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MMAR_3798|M.marinum_M PNNAFAATAVTDHRMVVPIPAGWSFAAAASIPVAFLTAYGAMVELGALAA Mflv_0405|M.gilvum_PYR-GCK ----GAQHVTDTDVVAPDQTCLWGFGRAASLEHPQIWGGLADLGGGTSDE MAB_0939|M.abscessus_ATCC_1997 ----GAQHVIEGDTVAPEQSALWGFGRAAALELPQVWGGLADLSDAGTDE MSMEG_0408|M.smegmatis_MC2_155 ----DGQRVTDTDTVVPEQSCLWGFGRAAALELPHIWGGLADLSGADT-E Mvan_1003|M.vanbaalenii_PYR-1 ----GAQRITGDETVEPAQTSLWGFGRAAALEQPELWGGLADVTTGDAEE TH_2454|M.thermoresistible__bu -------------------------------------------------- Mb2074c|M.bovis_AF2122/97 GQRVLIHAGTGGVGMAAVQLARHLGLEVFATASKGKWDTLRAMGFDDDHI Rv2048c|M.tuberculosis_H37Rv GQRVLIHAGTGGVGMAAVQLARHLGLEVFATASKGKWDTLRAMGFDDDHI MUL_2266|M.ulcerans_Agy99 GQRVLVHAATGGVGMAAVQLARHLGLEVYATASKGKWDILRAMGFDEDHI MAV_2450|M.avium_104 GQRVLVHAAAGGVGMAAVQLARHLGLEVFATASRGKWDTLRAMGFDDDHI MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MMAR_3798|M.marinum_M GRRVLIHAGAGGVGQAAIQIARHFGAEVYATAHPSKHHVLKALGVSGDRI Mflv_0405|M.gilvum_PYR-GCK WSRLLNRIAATHDPAVMEDQVAVRGSTSYVPRLVHRDTLPSGKPLHLR-- MAB_0939|M.abscessus_ATCC_1997 WAQFIGRVSVSGEASTREDQLALRGQAVHVPRLVRREELPSGKPLEVR-- MSMEG_0408|M.smegmatis_MC2_155 WPRLIARITSPRDG---EDQIALRGDAVYAPRLVRRTGEPSDTPLPVR-- Mvan_1003|M.vanbaalenii_PYR-1 WSALIDHIVAAPTS---EDQIAVRGREIHVARLTRCAEKANAAALELR-- TH_2454|M.thermoresistible__bu -------------------------------------------------- Mb2074c|M.bovis_AF2122/97 SDSRSLEFEDKFRAATGGRGFDVVLDSLAGEFVDASLRLVAPGGVFLEMG Rv2048c|M.tuberculosis_H37Rv SDSRSLEFEDKFRAATGGRGFDVVLDSLAGEFVDASLRLVAPGGVFLEMG MUL_2266|M.ulcerans_Agy99 SDSRSLEFEEKFREVTGGRSVDVVLDSLAGEFVDASLRLLGPGGVFLEMG MAV_2450|M.avium_104 GDSRTLEFEDKFRSATGGAGMDVVLDSLAGEFVDASLRLVAPGGVFLEMG MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MMAR_3798|M.marinum_M ASSRTFDFVDVFNQGTNGEGMDLVLNSLAGDFVDNSLRLLSQGGRLIEIG Mflv_0405|M.gilvum_PYR-GCK -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_1003|M.vanbaalenii_PYR-1 -------------------------------------------------- TH_2454|M.thermoresistible__bu -------------------------------------------------- Mb2074c|M.bovis_AF2122/97 KTDIRDPGVIAQQYPGVRYRAFDLFEAGPDRIAQILAELATLFGDGVLRP Rv2048c|M.tuberculosis_H37Rv KTDIRDPGVIAQQYPGVRYRAFDLFEPGRPRMHQYMLELATLFGDGVLRP MUL_2266|M.ulcerans_Agy99 KTDIRDPGVIAQEYPGVRYRAFDLFEPGRPRMHQYMLDLAGLFDAGVLRP MAV_2450|M.avium_104 KTDIRDPGVVAREYPGVRYRAFDLFEPGRPRMRQWMVELAGLFDAGVLNP MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MMAR_3798|M.marinum_M KTDIRVPNEVAAAHPGVIYRTYDLSSETPDRISQLWAALIEMISAGVLRP Mflv_0405|M.gilvum_PYR-GCK -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_1003|M.vanbaalenii_PYR-1 -------------------------------------------------- TH_2454|M.thermoresistible__bu -------------------------------------------------- Mb2074c|M.bovis_AF2122/97 LPVTTFDVRRAPAALRYLSQARHTGKVVMLMPG----SWAAGTVLITGGT Rv2048c|M.tuberculosis_H37Rv LPVTTFDVRRAPAALRYLSQARHTGKVVMLMPG----SWAAGTVLITGGT MUL_2266|M.ulcerans_Agy99 LPVTAFDVRRAPAALRYLSQARHVGKVVMTMPADQGGALGGGTVLITGGT MAV_2450|M.avium_104 LPVTTFDIRRGRAALRYLSQARHIGKVVMTVPG----ALSAGTVLITGGT MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MMAR_3798|M.marinum_M LPTTSYGLLQATQALRHMSQGRHTGKIVLLPPG---VFNSEGTVLVTGGT Mflv_0405|M.gilvum_PYR-GCK ---------------------------------------ADATYLVTGGL MAB_0939|M.abscessus_ATCC_1997 ---------------------------------------SDATYLVTGGL MSMEG_0408|M.smegmatis_MC2_155 ---------------------------------------EDRTYLVTGGL Mvan_1003|M.vanbaalenii_PYR-1 ---------------------------------------REATYLVTGGL TH_2454|M.thermoresistible__bu -------------------------------------------------- Mb2074c|M.bovis_AF2122/97 GMAGSAVARHVVARHGVRNLVLVSRRGPDAPGAAELVAELAAAGAQVQVV Rv2048c|M.tuberculosis_H37Rv GMAGSAVARHVVARHGVRNLVLVSRRGPDAPGAAELVAELAAAGAQVQVV MUL_2266|M.ulcerans_Agy99 GMAGSALARHLVAHHGVAHLVLISRRGPAAPGATELVAELSAAGAQVEVV MAV_2450|M.avium_104 GMAGSTLARHLVTGHGVRDLALLSRTGPDAPGAAEFVAELEAAGARVQVI MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MMAR_3798|M.marinum_M GMLGGVFAERLVAHYGARHLLLVSRSGPDAAGADELYQRLTQLGAQVTIT Mflv_0405|M.gilvum_PYR-GCK GSLGLEIAGYLAANG-AGHLVLTSRRTPDEAAASRIEALRERHGCEVRVV MAB_0939|M.abscessus_ATCC_1997 GSIGLEIAGYLAGRG-AKHLVLTSRREPGEAARQRIDALAA-QGCEVRAV MSMEG_0408|M.smegmatis_MC2_155 GAIGLEVAGYLASHG-AGHVVLTSRREPGDDARRRLDGLREQYACDVRVI Mvan_1003|M.vanbaalenii_PYR-1 GALGLEVAEFLASHG-AGHLVLTGRRSASDTVRQRIDAMRERFDCQVLVA TH_2454|M.thermoresistible__bu -------------------------------------------------- Mb2074c|M.bovis_AF2122/97 ACDAADRAALAKVIADIPVQHP-LSGVIHTAGALDDAVVMSLTPDRVDVV Rv2048c|M.tuberculosis_H37Rv ACDAADRAALAKVIADIPVQHP-LSGVIHTAGALDDAVVMSLTPDRVDVV MUL_2266|M.ulcerans_Agy99 ACDAADRPALAKVIAENPAQRP-LSAVVHAGGVLDDAVISSLTPERVDTV MAV_2450|M.avium_104 ACDAADRAALAGVIAGISAERP-LSGVIHAAGVLDDAMITSLTPERIDAV MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MMAR_3798|M.marinum_M ACDTSNPDELAAVLAGIPPQHP-LRAVVHTAGIVDDAVTTELTHEQLDTV Mflv_0405|M.gilvum_PYR-GCK TADVADAHAVARLLATVQAEMPPLAGIVHAAGEIGTTPLADLDDAEVDRV MAB_0939|M.abscessus_ATCC_1997 TADVADGHDVARLLAGIQAELPPLAGIVHAAGEIGTTPLSDLEDAEVDRV MSMEG_0408|M.smegmatis_MC2_155 TADVADAHDVARLMTTVAAELPPLAGIVHAAGEIGTTPLSGLDDAEVDRV Mvan_1003|M.vanbaalenii_PYR-1 TADVADRDDVARLFSTMRSELPPLAGIVHAAGEIGTSPLRTLDDAEMDRV TH_2454|M.thermoresistible__bu -------------------------------------------------- Mb2074c|M.bovis_AF2122/97 LRSKVDAAWHLHELTRDLD--VSAFVMFSSMAGLVGSSGQANYAAANSFL Rv2048c|M.tuberculosis_H37Rv LRSKVDAAWHLHELTRDLD--VSAFVMFSSMAGLVGSSGQANYAAANSFL MUL_2266|M.ulcerans_Agy99 LRAKVDAAWNLHELTRDLD--LSAFVMFSSMAGVVGSSGQANYAAANTFV MAV_2450|M.avium_104 LRAKVDAAWNLHELTRDMN--LSAFVMFSSMAGLVGSSGQGNYAAANSFL MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MMAR_3798|M.marinum_M LTAKADTAWHLHQLTTDAD--LDAFVVFSSVAGVLGAPGQANYAAANAFL Mflv_0405|M.gilvum_PYR-GCK FAGKVWGAWHLSEATSDLQ--LDFFISTSSIASVWGGFGQAAYGAANAFL MAB_0939|M.abscessus_ATCC_1997 FAGKVWGAWHLSEAAAGLK--LDFFINTSSIAAVWGGYGQTAYSAANAFL MSMEG_0408|M.smegmatis_MC2_155 FAGKVWGAWHLSEALTDLRTDLDFFVSTSSIASVWGGFGQTAYGAANAFL Mvan_1003|M.vanbaalenii_PYR-1 FAGKVWGAVYLCEEVADMG--LDFFLATSSIASVWGSHGQTAYGAANAFL TH_2454|M.thermoresistible__bu -------------------------------------------------- Mb2074c|M.bovis_AF2122/97 DALAAHRRAHGLPAISLGWGLWDQASAMTSGLDAADLARLGREGVLALST Rv2048c|M.tuberculosis_H37Rv DALAAHRRAHGLPAISLGWGLWDQASAMTGGLDAADLARLGREGVLALST MUL_2266|M.ulcerans_Agy99 DGLAAHRRAHGLPAISLGWGLWDQASDMTGGMDAADRARLGREGVLALSS MAV_2450|M.avium_104 DALAAHRRAHGLPAISLAWGLWDQASAMTGGLDAADLARLGRDGILALSS MLBr_00135|M.leprae_Br4923 ---------------------------MTASVEGADQK------------ MMAR_3798|M.marinum_M DALAHQRHRNHLPATSLAWGYWQTTSGMTAHLDTVDQARLTRNSLTPITT Mflv_0405|M.gilvum_PYR-GCK DGLAWRLREQGVAGVSVNFGPWSAGMADAQSRARLEQRGIKTLSPADALA MAB_0939|M.abscessus_ATCC_1997 DGLAWRLREQGIAGTSVNFGPWSAGMADAESRARLEQRGIKTLSPTDALA MSMEG_0408|M.smegmatis_MC2_155 DGLAWRLRERGVTAVSVNFGPWAAGMADAESRARLEQRGVRTLSPAEALA Mvan_1003|M.vanbaalenii_PYR-1 DGLADSLRARGIPGISVNFGPWAAGMADAKAREQLSRRGVKTLAPADALA TH_2454|M.thermoresistible__bu -------------------------------------------------- Mb2074c|M.bovis_AF2122/97 AEALELFDTAMIVDEPFLAPARIDLTALRAHAVAVPPMFSDLASAPTRRQ Rv2048c|M.tuberculosis_H37Rv AEALELFDTAMIVDEPFLAPARIDLTALRAHAVAVPPMFSDLASAPTRRQ MUL_2266|M.ulcerans_Agy99 DEAMELFDTALIVNQAFLAPARIDLAALRAHAVAVPPMFSDLVSAPTRRQ MAV_2450|M.avium_104 DEAMELFDTALIVDEPFLAPARIDLGALRAHAVAVPPMFADLVNAPTRRR MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MMAR_3798|M.marinum_M EHGLAMFDVALACQHPCLVPAPLNTQVLAGYARQNALPAILSAVTTTRR- Mflv_0405|M.gilvum_PYR-GCK GLSDAVISAAP---HPVVARVDWSRFLPLYQQAGRRGFLAELERELPAAP MAB_0939|M.abscessus_ATCC_1997 GLADVVAASGSNAVQGVIARIDWARFLPLYQQAGKRGFLAELDREVPSHL MSMEG_0408|M.smegmatis_MC2_155 GMADVVAGPVQ----GVVAKIDWSRFLPLYQQAGRRAFLSELESELPAAA Mvan_1003|M.vanbaalenii_PYR-1 GMADVIAASTA---HAVVARIDWATFLPVYQLQRRRAFLSQLEREVPDVP TH_2454|M.thermoresistible__bu -------------------------------------------------- Mb2074c|M.bovis_AF2122/97 VDDSVAAAKSKSALAHRLHGLPEAEQHAVLLGLVRLHIATVLGNITPEAI Rv2048c|M.tuberculosis_H37Rv VDDSVAAAKSKSALAHRLHGLPEAEQHAVLLGLVRLHIATVLGNITPEAI MUL_2266|M.ulcerans_Agy99 IDAALATAKSKSALAHRLHGLPELEQHAVVLDLVRSHIATVLGTITPEAI MAV_2450|M.avium_104 VDDSLAAAKSKSALAHRLDGLPEAEQHAVLLELVRSHIATVLGSPTAEAI MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MMAR_3798|M.marinum_M ----QATTTNTETFTSRLASQTPQQQLAILSDLVTDMTAAVLAHPDSAAL Mflv_0405|M.gilvum_PYR-GCK AQQGPAVTASGRTPLVERLTTAPLQQRKRLLTDYLRDAVAEVTRVDAAEI MAB_0939|M.abscessus_ATCC_1997 A--GVAGAQSGSTQLVERLANAPVQQRKKLLTDYLRDAVAEVTRVDVSEI MSMEG_0408|M.smegmatis_MC2_155 TGAAAPATVPGKPPLVEQLTKAPVQQRKSLITNYLRNAVAEVTRVDADEI Mvan_1003|M.vanbaalenii_PYR-1 D--ASAPAPSGTTRFVEELTLAPVEQRRKLVLEYLRAAVAEVTRVDAAEI TH_2454|M.thermoresistible__bu -------------------------------------------------- Mb2074c|M.bovis_AF2122/97 DPDKAFQDLGFDSLTAVEMRNRLKSATGLSLSPTLIFDYPTPNRLASYIR Rv2048c|M.tuberculosis_H37Rv DPDKAFQDLGFDSLTAVEMRNRLKSATGLSLSPTLIFDYPTPNRLASYIR MUL_2266|M.ulcerans_Agy99 DPDKAFQELGFDSLTAVEMRNRIKTVTGLSLSPTLIFDYPTPNGLANYIR MAV_2450|M.avium_104 DPDKAFQELGFDSLTAVEMRNRLKTATGLALSPTLIFDYPTPNALAGYIR MLBr_00135|M.leprae_Br4923 -----------------------------------------SEKLISYLK MMAR_3798|M.marinum_M DADLPFKDLGIDSLSALELRNSLARHTGLTLSATLVFDHPTPTAIAHHLV Mflv_0405|M.gilvum_PYR-GCK REDAGFFDLGMDSLMAVELRRRIETGVGKEIPVTLVMDHPRLSDAADYLL MAB_0939|M.abscessus_ATCC_1997 REDAGFFDLGMDSLMAVELRRRMEQGVGKEIPVTLVMDHPRISDVADYLL MSMEG_0408|M.smegmatis_MC2_155 RDEAGFFDLGMDSLMAVELRRRIEQGVGKDIPVTLVMDHPRLSDAADYLL Mvan_1003|M.vanbaalenii_PYR-1 RDEAGFFDLGMDSLMAIELRRRLEQGLGKELPVTLAMDHPHLSDAAEYVL TH_2454|M.thermoresistible__bu -------------------------------------------------- Mb2074c|M.bovis_AF2122/97 TELAGLPQEIK----HTPAVRTTSEDPIAIVGMACRYPGGVNSPDDMWDM Rv2048c|M.tuberculosis_H37Rv TELAGLPQEIK----HTPAVRTTSEDPIAIVGMACRYPGGVNSPDDMWDM MUL_2266|M.ulcerans_Agy99 AELAGAPQEVK----HTPAVRVTGDDPIAIVGMSCRYPGGIESPDDLWDM MAV_2450|M.avium_104 TELAGAPQETT----HAPVVRATDDDPIAIVGMSCRFPGGVDSPEALWQM MLBr_00135|M.leprae_Br4923 KVVVELDETRA----RLREYEQRATEPVAVVGIGCRFPGGVDSPDRLWDV MMAR_3798|M.marinum_M DQLSAAAPPAP----VATPVKANAEEPVVVVGMACRLPGGIESAAGLWDV Mflv_0405|M.gilvum_PYR-GCK GDVLGLTEAAT-APKAATVVSTAADEPIAIVAVSCRFPG-APNPEAFWDL MAB_0939|M.abscessus_ATCC_1997 GDVLGLAEQAKPAAQLASAVTGRTDEPIAIVAVSCRFPG-APDPEAFWDV MSMEG_0408|M.smegmatis_MC2_155 VEVLGLGEQTN--VRQASTVTARTDDPIAVVAVSCRFPG-APDPESFWEL Mvan_1003|M.vanbaalenii_PYR-1 GDVLGLSEHTV--AQPDTPSTVRTDDPIAIVGMACRFPG-ADDTDAFWSV TH_2454|M.thermoresistible__bu -------------MSVDVTAKARPDDPIAIIGIGCRLAGRITSPEEFWGF :*:.::.:.** .* .. :* . Mb2074c|M.bovis_AF2122/97 LIQGRDVLSEFPADRGWDLAGLYNPDPDAAGACYTRTGGFVDGVGDFDPA Rv2048c|M.tuberculosis_H37Rv LIQGRDVLSEFPADRGWDLAGLYNPDPDAAGACYTRTGGFVDGVGDFDPA MUL_2266|M.ulcerans_Agy99 LMARRDVLSDFPADRGWDLAGLFNPDPDVPGACYTRTGGFVDRVGDFEPA MAV_2450|M.avium_104 VAEGRDVLSEFPTDRGWDLAGVYNPDPDVPGTCYTRTGGFVDNVADFDPA MLBr_00135|M.leprae_Br4923 VSECRDVVSEFPTDRGWDVDGLFDPDPDAEGKTYTRWGAFLDDAAGFDAG MMAR_3798|M.marinum_M VSGAADVMGAFPTDRGWDVAGLFDPDPDSVGKTYTRYGGFISSAAEFDAE Mflv_0405|M.gilvum_PYR-GCK LSGGVDAIREVPEDR-FDIDEFYDPDPDAAGKTYTRYGGFLDHIDEFDPE MAB_0939|M.abscessus_ATCC_1997 LSGGVDAIREVPEDR-FDIDEFYDPDPEVAGKTYTRFGGFLDGIDGFDPE MSMEG_0408|M.smegmatis_MC2_155 LAGGVDAIREVPEDR-WDIDEFYDPDPDTPGKTYTRFGGFLDGIDGFDPE Mvan_1003|M.vanbaalenii_PYR-1 LAEGADLIREIPDDR-FDINEFYDPDPEAAGKIYSRYGGFLDGVDGFDPE TH_2454|M.thermoresistible__bu LLAGGSNVREIPAER-WEPYLRRDPRNAAVLREITPWGTFLDDLAGFDAE : . : .* :* :: :* : * *:. *:. Mb2074c|M.bovis_AF2122/97 FFGVGPSEALAMDPQQRMLLELSWEALERAGIDPTGLRGSATGVFAGVMT Rv2048c|M.tuberculosis_H37Rv FFGVGPSEALAMDPQHRMLLELSWEALERAGIDPTGLRGSATGVFAGVMT MUL_2266|M.ulcerans_Agy99 FFGVGPSEALAMDPQQRMFLELSWEALERAGIEPGGLRGSATGVFAGVMT MAV_2450|M.avium_104 FFGIAPSEALAMDPQQRMFLELSWEALERAGIDPVKLRGSATGMFAGVYT MLBr_00135|M.leprae_Br4923 FFGIAPSEVLAMDPQQRLMLEVSWEALEYAGIDPLSLRGSATGVFTGIFA MMAR_3798|M.marinum_M FFGISAREAAAMDPQQRVLLEVCWEALEHAGIEPGTLEGSNTGVFIGAYA Mflv_0405|M.gilvum_PYR-GCK FFGLSPREAVWIEPQQRLMLETVWEGLERAGYAPSALRGSRTGVFVGVAA MAB_0939|M.abscessus_ATCC_1997 FFGISPREAVWIEPQQRLMLETVWEGLERAGYSPAALRGSRTGIFAGVGA MSMEG_0408|M.smegmatis_MC2_155 FFGISPREAVWIEPQQRLMLETVWEGLERAGYAPSDLRGSRTGVFTGVAA Mvan_1003|M.vanbaalenii_PYR-1 FFGISPREAVWIDPQQRLVLETAWEGLERAGYSAAALRGSRSGVYVGVGA TH_2454|M.thermoresistible__bu FFGVSPREAELTDPQQRLALEVSWEALEHAGVPPRSLAGTDTAVLMGVNS ***:.. *. :**:*: ** **.** ** . * *: :.: * : Mb2074c|M.bovis_AF2122/97 QGYGMFAA----EPVEGFRLTGQLSSVASGRVAYVLGLEGPAVSVDTACS Rv2048c|M.tuberculosis_H37Rv QGYGMFAA----EPVEGFRLTGQLSSVASGRVAYVLGLEGPAVSVDTACS MUL_2266|M.ulcerans_Agy99 QGYGMFAA----EPVEGFRLTGQLSSVASGRVAYVLGLEGPAVSVDTACS MAV_2450|M.avium_104 QGYGMGAA----PIAEGFRLTGQSSSVASGRVSYVLGLEGPAVSVDTACS MLBr_00135|M.leprae_Br4923 PSYGSRDT----GGLQGYGLTGTAVSVASGRVSYVLGLEGPAVSVDTACS MMAR_3798|M.marinum_M QRYGDSDS----DSGEGFALTGGATSVASGRVAYVLGLQGPAITVDTACS Mflv_0405|M.gilvum_PYR-GCK NEYAHLLSAESIDKIEPHFITGNALNAISGRVAFALGLEGPAVAVDTACS MAB_0939|M.abscessus_ATCC_1997 NEYAHLLSSESIDKIEPYFITGNALNAISGRVAFALGFEGPAVAVDTACS MSMEG_0408|M.smegmatis_MC2_155 NEYAHLLSAESIDKIEPHFITGNALNAISGRVAFALGFEGPAVAVDTACS Mvan_1003|M.vanbaalenii_PYR-1 NEYSHLLSGGSLDGIEAQFITGNALNVIAGRVSFTLGLEGPAVAVDTACS TH_2454|M.thermoresistible__bu DDYGRLLMED-LPGIEAWTGIGTSLCGIANRVSHLLDLRGPSVALDAACA *. : * :.**:. *.:.**::::*:**: Mb2074c|M.bovis_AF2122/97 SSLVALHMAVGSLRSGECDLALAGGVTVNATPDIFVEFSRWRGLSPDGRC Rv2048c|M.tuberculosis_H37Rv SSLVALHMAVGSLRSGECDLALAGGVTVNATPDIFVEFSRWRGLSPDGRC MUL_2266|M.ulcerans_Agy99 SSLVALHMAVQSLRSGECDLALAGGVTINATPDIFVEFSRWRGLSADGRC MAV_2450|M.avium_104 SSLVALHMAVQSLRSGECDLALAGGVTVNATPDIFVEFSRMRGLSVDGRC MLBr_00135|M.leprae_Br4923 SSLVAIHWAMSSLRSGECDLALAGGVTVMGLPSIFVGFSRQRGLAADGRC MMAR_3798|M.marinum_M SSLVAAHLACQSLRNGESSLALAGGVTIMATPAPFIEFARQRGLAADGRC Mflv_0405|M.gilvum_PYR-GCK SSLVAVHQATQALRSGDCDMALAGGVNVLLSPVTVVAASRARMLSPVGRC MAB_0939|M.abscessus_ATCC_1997 SALVAVHQAVQALHSGDCDLALAGGVNVLLSPVTVIAASRARMLSPVGRC MSMEG_0408|M.smegmatis_MC2_155 SALVAVHQACQALQSGDCDLALAGGVNVLLSPVTVVAASRARMLSPVGRC Mvan_1003|M.vanbaalenii_PYR-1 SSLVAVHQACQGLQSGDCDLALAGGVNVLLSPATTIATSRARMLSPDGRC TH_2454|M.thermoresistible__bu ASLVAVHNACQLLRAGETGLAIAGGVSALIGPGLTRVLDKAGATAPDGRC ::*** * * *: *: .:*:****. * : : *** Mb2074c|M.bovis_AF2122/97 KAFAAAADGTGFSEGGGMLVLQRLSDARRLGHPVLAVVVGSAVNQDGASN Rv2048c|M.tuberculosis_H37Rv KAFAAAADGTGFSEGGGMLVLQRLSDARRLGHPVLAVVVGSAVNQDGASN MUL_2266|M.ulcerans_Agy99 KAFAGAADGTGFSEGGGMLVVERLSDAQRLGHPVLALVRGSAVNQDGASN MAV_2450|M.avium_104 KAYAGAADGTGFSEGGGMLVVERLSDARRLGHPVLAVVRGSAVNQDGASN MLBr_00135|M.leprae_Br4923 KAFARAADGTGWGEGAGVVVLERLSDAQRLGHTVLAVVRGSAVNQDGASN MMAR_3798|M.marinum_M KAFAAAADGTGWGEGAAVLVLERLSDARRNRHPVLAVIAGSAVNQDGASN Mflv_0405|M.gilvum_PYR-GCK KTFDASADGYVRSEGCGILVLKRLSDAVRDGDRVCAVIAGSAVNQDGASS MAB_0939|M.abscessus_ATCC_1997 KTFDASADGYVRSEGCGILVLKRLSDAERDGDRVLAVIPGSAVNQDGASS MSMEG_0408|M.smegmatis_MC2_155 KTFDASADGYVRSEGCGVLVLKRLSDAVRDGDRVCAVIPASSVNQDGASS Mvan_1003|M.vanbaalenii_PYR-1 KTFDAAADGYVRGEGCGILVLKRLSDAVRDGDRIQAVIRGSAVNQDGASG TH_2454|M.thermoresistible__bu KSFDASADGYGRGEGAAVVILKRLPDALRDGDRVIAVIRGGAVAQDGRTV *:: :*** .** .:::::**.** * . : *:: ..:* *** : Mb2074c|M.bovis_AF2122/97 GLTAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQALL Rv2048c|M.tuberculosis_H37Rv GLTAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQALL MUL_2266|M.ulcerans_Agy99 GLTAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQALL MAV_2450|M.avium_104 GLTAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTLGDPIEAQALL MLBr_00135|M.leprae_Br4923 GLTAPNGLAQQRVIQAALTNAGLSSADVDVVEAHGTATTLGDPIEAQALL MMAR_3798|M.marinum_M GLSAPNGPAQQRVIAQAAANAGIALDQVDVVEAHGTGTTLGDPIEAGALI Mflv_0405|M.gilvum_PYR-GCK GLTVPNGGAQQRLIGTVLARAGITGGEVDYLEAHGTGTPLGDPIEVQAAA MAB_0939|M.abscessus_ATCC_1997 GLTVPNGGAQQRLIGSVLARAGLVGGDVDYLEAHGTGTPLGDPIEVQAAA MSMEG_0408|M.smegmatis_MC2_155 GLTVPNGGAQQRLIEATLARAGLSGADVDYLEAHGTGTPLGDPIEVQAAA Mvan_1003|M.vanbaalenii_PYR-1 GLTVPNGGAQQRVIAAALTRAGLSGSDIDYLEAHGTGTSLGDPIEVQAAG TH_2454|M.thermoresistible__bu GIMSPNGAAQRDLFRHTCEITGTSPATVDFVEAHGTGTPTGDPVELDALA *: *** :*: :. . :* :* :*.***.*. ***:* * Mb2074c|M.bovis_AF2122/97 ATYGQDRGEP---GEPLWLGSVKSNMGHTQAAAGVAGVIKMVLAMRHELL Rv2048c|M.tuberculosis_H37Rv ATYGQDRGEP---GEPLWLGSVKSNMGHTQAAAGVAGVIKMVLAMRHELL MUL_2266|M.ulcerans_Agy99 ATYGQDRGSAGAAGKALWLGSIKSNMGHTQAAAGVAGVIKMVQAMRHEVL MAV_2450|M.avium_104 ATYGQDRGQP------LWLGSIKSNMGHTQAAAGVAGVIKMVLAMRHELL MLBr_00135|M.leprae_Br4923 ATYGQGRPAD----QPLWVGSIKSNMGHTQAAAGVAGVIKMVQAMRHHVM MMAR_3798|M.marinum_M ATYGTHRDPE----HPLWLGSVKSNIGHTQAAAGAAGLIKMIQAMRHGVL Mflv_0405|M.gilvum_PYR-GCK AAYAGARDAD----RPLLMGSVKTNIGHTESASGAAGLIKVVLSLQHETL MAB_0939|M.abscessus_ATCC_1997 AAYGGSRDAD----RPLLMGSVKSNIGHTESASGAAGLIKVVLSLQNGVL MSMEG_0408|M.smegmatis_MC2_155 AAYGAGRDAD----RPLLMGSVKTNIGHTESASGAAGLIKVVLSLQHGVL Mvan_1003|M.vanbaalenii_PYR-1 AVLGAGRDPD----RPLLMGSVKTNVGHLESASGVAGLIKVVLSLQHEML TH_2454|M.thermoresistible__bu AVYGAAHGPD----DPCRVGSVKPNTGHLEGGAGVVGLIKAALALQHGVI *. . : :**:*.* ** :..:*..*:** :::: : Mb2074c|M.bovis_AF2122/97 PATLHVDVPSPHVDWSAGAVELLTAPRVWP---AGARTRRAGVSSFGISG Rv2048c|M.tuberculosis_H37Rv PATLHVDVPSPHVDWSAGAVELLTAPRVWP---AGARTRRAGVSSFGISG MUL_2266|M.ulcerans_Agy99 PATLHVDVPSPHVDWSAGAVELLTEAQPWPAESAGDRVRRAGVSSFGISG MAV_2450|M.avium_104 PATLHVDEPSPHVDWSAGAVSLLTEAQPWP----GERPRRAGVSSFGISG MLBr_00135|M.leprae_Br4923 PATLHVDEPSPRVDWTTGAVSVLTEARDWS---VEGRPRRAGVSSFGISG MMAR_3798|M.marinum_M PKTLHVNAPTPQVDWSAGTVRLLTETMPWP---DTDHLRTAAVSSFGVSG Mflv_0405|M.gilvum_PYR-GCK PQSLHFDTPSPHIPWDSLPVRVVDTAMPWQ---PNGRPRRAGVSSFGFTG MAB_0939|M.abscessus_ATCC_1997 PQSLHFDNPSPHIPWESLPVRVVDKAIPWQ---ANGRPRRAGVSSFGFTG MSMEG_0408|M.smegmatis_MC2_155 PQSLHFENPSPHIPWDALPVRVIDEPVPWQ---TNGRVRRAGVSSFGFTG Mvan_1003|M.vanbaalenii_PYR-1 PRHLHFKTPSPHIPWDRLAVRVVAEPTPWR---ADGRPRRAGVSSFGFSG TH_2454|M.thermoresistible__bu PPTAGIRELTPAVDWATNGLHVPTTVEPFPR--RADSPRRAAVCSYGYGG * . :* : * : : : * *.*.*:* * Mb2074c|M.bovis_AF2122/97 TNAHVIIEAVP---------------VVPRR-EAGWAGPVVPWVVSAKSE Rv2048c|M.tuberculosis_H37Rv TNAHVIIEAVP---------------VVPRR-EAGWAGPVVPWVVSAKSE MUL_2266|M.ulcerans_Agy99 TNAHVIVEAAP---------------RVEVGGSSGGAVPVVPWVVSAKSG MAV_2450|M.avium_104 TNAHVIIEAVP---------------AVEPAHADAPALPVLPWVVSAKSA MLBr_00135|M.leprae_Br4923 TNAHVILEEAPT------------PVEASYSTADQQRLSVVPWVVSGRST MMAR_3798|M.marinum_M TNAHLIVQQGSPG-----------PAVAVHQASPSQECSLGVWPLSARSS Mflv_0405|M.gilvum_PYR-GCK TNAHVLIEEAPTDLAGPTEPTAPAEPVDEDAAADPAPAPVEVLPLSARSP MAB_0939|M.abscessus_ATCC_1997 TNAHVLIEEAPQPQATP----------DEDDASTPQSAPVSVLPLSARSP MSMEG_0408|M.smegmatis_MC2_155 TNAHVLVEEAPPQLHTADAAP----VEPAATAEAGTDDSPQVLALSARSP Mvan_1003|M.vanbaalenii_PYR-1 TNAHVVLEEPPAQSADLRQPPTDGKDGAAGLESATAPEPAGVLPISARSP TH_2454|M.thermoresistible__bu TIAHLLLEEAPAVDETPAAAP-----APAADAADANSPRFHVIPVSARSG * **:::: . :*.:* Mb2074c|M.bovis_AF2122/97 SALRGQAARLAAYVRGDDGLDVADVGWSLAG-RSVFEHRAVVVGG----- Rv2048c|M.tuberculosis_H37Rv SALRGQAARLAAYVRGDDGLDVADVGWSLAG-RSVFEHRAVVVGG----- MUL_2266|M.ulcerans_Agy99 SALGAQAARLAAHVRSHDELDVADVGWSLAG-RSTFEHRAVVLGA----- MAV_2450|M.avium_104 AALRAQAARLAEYVRAQGELDIADVGWTLAG-RATFEHRAVVVGG----- MLBr_00135|M.leprae_Br4923 AALMAQASRLAFYVQADPEVDPVDVGCALAA-RSVFEHRAVVVGE----- MMAR_3798|M.marinum_M AGLSAQAHRLHEYLLGHSDLDLIDLAYSLATTRTHHSYRAAVTVPGCTDN Mflv_0405|M.gilvum_PYR-GCK EALVALAQRYETWLTAHPEADLADVCRTAGTGRSHFEHRAALVVD----- MAB_0939|M.abscessus_ATCC_1997 EALAAVAQRYESWLAAHPDVDLEDVCLTAGRGRSHFEHRAALVVD----- MSMEG_0408|M.smegmatis_MC2_155 EALVELARRYDDWLSATPGLDIADVCHTAGVGRSHFEYRAALVVD----- Mvan_1003|M.vanbaalenii_PYR-1 EALTALARRYESWLTAHPDADIADVCYTAGAGRSHFEHRAALVVD----- TH_2454|M.thermoresistible__bu ARLARHAAALRGHLSAG--ADLTAVAATMWQRRSHEPVRAAVIAR----- * * : . * : : *: **.: Mb2074c|M.bovis_AF2122/97 DRDRLLAGLDELAGDQLG--GSVVRGTATAAGKTVFVFPGQGSQWLGMGM Rv2048c|M.tuberculosis_H37Rv DRDRLLAGLDELAGDQLG--GSVVRGTATAAGKTVFVFPGQGSQWLGMGM MUL_2266|M.ulcerans_Agy99 DRDGLLAGLDELAGDEFGG-ASVIRGVAGAAGKTVFVFPGQGSQLLGMGM MAV_2450|M.avium_104 DRDRLLAGLDELAADDPA--ASIIRGVATPAGKTVFVFPGQGSQTLGMGR MLBr_00135|M.leprae_Br4923 SREQLIAGLAGLAVGESG--AGVAIGQAAPLGKTVVVFPGQGAQRIGMGR MMAR_3798|M.marinum_M AHHDLLGGLTALAAGQTHPFVANHYCRAGQNGKTVFVFPGQGGQYPAMAA Mflv_0405|M.gilvum_PYR-GCK SVESARIALTDLAQNRLR--PGVVRGEHLNHPTTAWMFTGQGSQYPGMAR MAB_0939|M.abscessus_ATCC_1997 SIQTAREGLLELAQNRLR--PGVVRGEHTNHPTTAWLFTGQGSQYPGMAR MSMEG_0408|M.smegmatis_MC2_155 SVERAREGLAALAEGRTP--AGVVRGEHVHRPTTAWLFTGQGSQYPGMAR Mvan_1003|M.vanbaalenii_PYR-1 SVDGARDLLAGLAEDRLG--PGAVRGVCGDPPKTAWLFTGQGSQYPGMAR TH_2454|M.thermoresistible__bu HPGELVAGLDAIATDTRHPAVVAGSVLPAAEAGAVWVFSGHGSHWPGMGR * :* . :. :*.*:*.: .*. Mb2074c|M.bovis_AF2122/97 GLHAGYPVFAEAFNTVVGELDRHLLRPLREVMWGH--------DENLLNS Rv2048c|M.tuberculosis_H37Rv GLHAGYPVFAEAFNTVVGELDRHLLRPLREVMWGH--------DENLLNS MUL_2266|M.ulcerans_Agy99 GLHAGYPVFAEAFNTVVGELDRHLLRPLREVIWGH--------DENLLNT MAV_2450|M.avium_104 QLHAGYPVFAEAFDAVVAELDRHLLRPLRDVIWGD--------DENVLNS MLBr_00135|M.leprae_Br4923 ELCSQLPVFAEEFDAVTGELDRHMRLPLRDVVWGA--------DAGLLDS MMAR_3798|M.marinum_M ELYRQHPGFATAVDECDAELRPYTGWSVRDVICQD-------PDAPSLEL Mflv_0405|M.gilvum_PYR-GCK ELFDTEPVFADTVTRCADAVADLLPRPLLDVMFAGGREAGVP-PTETLRH MAB_0939|M.abscessus_ATCC_1997 ELFDAEPVFAETVTRCAEAVKDIVTRPLLEVMFATDRETGGK-AGEALRH MSMEG_0408|M.smegmatis_MC2_155 ELFDTQPVFAQTVRQCAEAVADMLPRPLLDVLFATDRET-----ADLLQH Mvan_1003|M.vanbaalenii_PYR-1 ELFDTEPVFRDTVTRCAEAIGDTLPRPLLEVLFDTDGDN-----GQTLRH TH_2454|M.thermoresistible__bu ELLEHEPVFAAVIDEIEPVFRAELGFSPRQALQSG-----------ELGG * * * . . . :.: * Mb2074c|M.bovis_AF2122/97 TEFAQPALFAVEVALFRLLGSWGVRPDFVMGHSIGELSAAHVAGVLSLEN Rv2048c|M.tuberculosis_H37Rv TEFAQPALFAVEVALFRLLGSWGVRPDFVMGHSIGELSAAHVAGVLSLEN MUL_2266|M.ulcerans_Agy99 TEFAQPALFAVEVALYRLLESWGVRPDFVMGHSVGELSAAHVAGVLSLEN MAV_2450|M.avium_104 TEFAQPALFAVEVALFRLLESWGVRPDFVMGHSIGELSAAHVAGVLSLQN MLBr_00135|M.leprae_Br4923 TEFAQPALFAVEVALFAVLQHWGLQPDFVMGHSIGELAAAYVAGVLAPAD MMAR_3798|M.marinum_M VEVIQPVLFAVMIALAETLRGYGIVPDAVIGHSQGEIAAAYIAGALTLAE Mflv_0405|M.gilvum_PYR-GCK TSFAQPALFAVEMGLARLWQSWGIVPDVVLGHSVGQYAAACVAGVFSLED MAB_0939|M.abscessus_ATCC_1997 TSFAQPALFAVEMGLARLWQSWGIEPDVVLGHSVGQYAAACVAGVFSIED MSMEG_0408|M.smegmatis_MC2_155 TSFAQPALFAVEMGLARLWQSWAIEPDVVLGHSVGQYAAACVAGVFSLDD Mvan_1003|M.vanbaalenii_PYR-1 TSYAQPALFAIEMGLARLWQARGIEPDVVLGHSVGQYAAACVAGVFGLED TH_2454|M.thermoresistible__bu TDRVQALTFAVQAGLAAVLRDRGVKPAAVIGHSVGEVAACVAAGVFDLAR .. *. **: .* .: * *:*** *: :*. **.: Mb2074c|M.bovis_AF2122/97 AAVLVAARGRLMQALPAGGAMVAVQAAEEEVRPLLS---AEVDIAAVNGP Rv2048c|M.tuberculosis_H37Rv AAVLVAARGRLMQALPAGGAMVAVQAAEEEVRPLLS---AEVDIAAVNGP MUL_2266|M.ulcerans_Agy99 AAVLVAARGRLMQALPDGGAMIAVQATEQEVLPLLG---AQVSIATINGP MAV_2450|M.avium_104 AAVLVAARGRFMQALPEGGAMIAVQATEAQVRPLLG---PDVGIAAVNGP MLBr_00135|M.leprae_Br4923 AAMLVVARGRLMQSMPAGGTMWAVAASEDEVVSLLG---EGVGIAAINAP MMAR_3798|M.marinum_M AAKVVALRSAALAQLAGTGTMASVLLSPEELRPLLQPWNTQISIAAINGP Mflv_0405|M.gilvum_PYR-GCK GARLMAERGRLFGSLPEGGRMVAVFADAKRVEQVAA-DFPRVSVGAYNGP MAB_0939|M.abscessus_ATCC_1997 GARLIAERGRLFGGLPAGGRMVAVFSDAKHVEQIAG-EFPRVSVGAYNGP MSMEG_0408|M.smegmatis_MC2_155 GARLMAERGRMFGSLPEGGRMVAVFADAEHVEQVAG-EFPRVSVGAYNGP Mvan_1003|M.vanbaalenii_PYR-1 GARLVADRGRLFGGLPVGGRMVAVFTDAEVVEDFAD-EFPQVSVAAYNGP TH_2454|M.thermoresistible__bu GAAVACYRARGFRSVAGKGAMALVGLPFEDARQRLG-ERTDVVAAISASP .* : *. : :. * * * : . .* Mb2074c|M.bovis_AF2122/97 ASLVISGAQNAVAAVADQLRADGRRVHQLAVSHAFHSPLMDPMIDEFAAV Rv2048c|M.tuberculosis_H37Rv ASLVISGAQNAVAAVADQLRADGRRVHQLAVSHAFHSPLMDPMIDEFAAV MUL_2266|M.ulcerans_Agy99 ASVVISGAQDAVSAVAEQLRADGRRVHRLAVSHAFHSPLMDPMIDEFATV MAV_2450|M.avium_104 AAVVISGDHDAAVAIAERLRAEGHRVHRLSVSHAFHSPLMEPMIDEFGTV MLBr_00135|M.leprae_Br4923 ESVVISGPQAAVSAIADKFAAQGRRVHQLAVSHAFHSPLMEPMLEEFVRV MMAR_3798|M.marinum_M AHTIISGDTTAVEQFIGTCEDGGVQIRPIAVDYASHSAHVERLREHLLHE Mflv_0405|M.gilvum_PYR-GCK N-TVLSGPGEDLEQIVGTFGEDGIRCTWLETSHAFHSELLDPVLDEFESY MAB_0939|M.abscessus_ATCC_1997 N-TVLSGPGEDLEQAVARFQEEGIRCTWLETSHAFHSELLDPILDEFESY MSMEG_0408|M.smegmatis_MC2_155 N-TVLSGPGEDLEEIVERFEDEGIRCTWLATSHAFHSELLDPVLDEFEAY Mvan_1003|M.vanbaalenii_PYR-1 N-TVLAGPASDLEQIVAGCSGEGIRTTWLDTSHAFHSALLDPVLDEFESC TH_2454|M.thermoresistible__bu LSTVISGTVDAVGEVSAAWAEQGVMVRKVNTDVAFHSPAMDALTAELARL :::* * : .. * ** :: : .: Mb2074c|M.bovis_AF2122/97 AAGIAIGRPTIGVISNVTGQLAGDDFGS----AAYWRRHIRQAVRFADSV Rv2048c|M.tuberculosis_H37Rv AAGIAIGRPTIGVISNVTGQLAGDDFGS----AAYWRRHIRQAVRFADSV MUL_2266|M.ulcerans_Agy99 AGELTVNAPTIGIISNLTGQLAGEDFGS----AAYWKRHVRDAVRFADSI MAV_2450|M.avium_104 AAGLAIDKPVIPIISNLTGQPAADDFGS----PEYWKCHVRDAVRFADSV MLBr_00135|M.leprae_Br4923 AAQVEVRKPQIGLVSNVTGELAGPDFGS----PQYWGEHVSRAVRFVDSA MMAR_3798|M.marinum_M LADLNPQPARIPLYSTVASELSEHPLDTTAMDAEYWYRNLREPVEFYSCV Mflv_0405|M.gilvum_PYR-GCK AAQLQFAAPTLPLVCNRTGAVLTGQTSLD---AQYWRRHSRQPVQFAESV MAB_0939|M.abscessus_ATCC_1997 AAQVQFAAPTLPLVCNRTGAVLTAQTPID---GQYWRRHSRQPVQFAESV MSMEG_0408|M.smegmatis_MC2_155 AAQFQFAAPTLPLVCNRTGAVLTGQTPLD---AQYWRRHSRQPVQFAESV Mvan_1003|M.vanbaalenii_PYR-1 AARLAYAAPTRPLVCNRTGAVVTGPGVID---AQYWRRHARQPVQFAESV TH_2454|M.thermoresistible__bu TSTLTPKPAAVPLYSTALADPRSTAARD----EHYWVANLRGRVRFAEAV . . . : .. . ** : *.* .. Mb2074c|M.bovis_AF2122/97 RFAQAAGGSRFLEVGPSGGLVASIEESLPDVAVT----TMSALRKDRPEP Rv2048c|M.tuberculosis_H37Rv RFAQAAGGSRFLEVGPSGGLVASIEESLPDVAVT----TMSALRKDRPEP MUL_2266|M.ulcerans_Agy99 RFAQSAGAARFLEVGPSIGLTASIEEVLSDAAVTNPVATASALRKDRPEP MAV_2450|M.avium_104 RFAQSAGATRFLEVGPSSGLTAAIEETLADAPVV----TVSALRKDRPEP MLBr_00135|M.leprae_Br4923 RHLQTLGATHFIESGPSSGLMGAIEQSLAPAEAV----VVSMMGKDRPEL MMAR_3798|M.marinum_M AQLLAHSERVFVELSPHPVLASALTDALADTGQLTQSAVVTTLRRDRPDM Mflv_0405|M.gilvum_PYR-GCK RTVAALGCSVLMEIGPQPVLTGAAVQVWPEHLAAPR--AIASLRKGVADR MAB_0939|M.abscessus_ATCC_1997 RTVAALGCSVLMEIGPQPVLTGAAVQVWPEHLAPPR--AIVSLRKGVEDR MSMEG_0408|M.smegmatis_MC2_155 RTVAALGCSVLMEIGPQPVLTGAAVQVWPEHMAAPR--AVASLRKGVADR Mvan_1003|M.vanbaalenii_PYR-1 RTLADLGCSVLMEIGPQPFLIAAALRVWPESAATPR--AIPSLRKGPDAR TH_2454|M.thermoresistible__bu TAAAEDGHRLFLEVSAHPVVCHSMAETLALAEVGEH-AVLPVLRREQPEL . ::* .. : : . . : : Mb2074c|M.bovis_AF2122/97 ATLTNAVAQGFVTGMDLDWRAVVG--EAQFVELPTYAFQRRRFWLS-GDG Rv2048c|M.tuberculosis_H37Rv ATLTNAVAQGFVTGMDLDWRAVVG--EAQFVELPTYAFQRRRFWLS-GDG MUL_2266|M.ulcerans_Agy99 VSLVSALAGVFVAGTAVDWRAVVG--QSHFVELPTYAFERRRFWLS-GDA MAV_2450|M.avium_104 VALVNAVAQGWVCGMDVDWRGALG--TGHLVDLPTYAFDRRRFWLS-GDG MLBr_00135|M.leprae_Br4923 ASVLGAAGQLFATGMPVEWPAVFAGSSRRRVTLPTYAFQRRRFWETPGTD MMAR_3798|M.marinum_M DMVASAIANLHVHGHSPSWQKIYP--GATTVELPTYAFQRRHYWLAAPTP Mflv_0405|M.gilvum_PYR-GCK RQIADALAAAYIGGHKPDFAALHEQ-RGVRLELPTYPFQRRRFWPKSAGM MAB_0939|M.abscessus_ATCC_1997 RQIADALASAYVSGHRPNFAALQRH-PRRTVELPTYPFQRRRFWPKSSGT MSMEG_0408|M.smegmatis_MC2_155 RQIADALASAYVGGHRPDFAAVHRQ-PRRPVELPTYPFQRRRFWPKASSI Mvan_1003|M.vanbaalenii_PYR-1 RQLAEAVAAAYIAGHRLDFTGHDGG-PHRRLPLPTYPFQHRSYWPKTAGI TH_2454|M.thermoresistible__bu PAVAAVVGALYCHGAPVRPAFPPG--TRWATGLPGTQWQHRRFWRTPGTP : . . * ** :::* :* Mb2074c|M.bovis_AF2122/97 VAADAAS------------------------------------------- Rv2048c|M.tuberculosis_H37Rv VAADAAG------------------------------------------- MUL_2266|M.ulcerans_Agy99 VPADAAG------------------------------------------- MAV_2450|M.avium_104 AASDAAG------------------------------------------- MLBr_00135|M.leprae_Br4923 GTASVSG------------------------------------------- MMAR_3798|M.marinum_M TPATVSDPAEVALWDAVNDDAVDTVARVLRIDNAQSMVSLGPMVRALREW Mflv_0405|M.gilvum_PYR-GCK AIDGRVG------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 AIEG--G------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 AVDG---------------------------------------------- Mvan_1003|M.vanbaalenii_PYR-1 RSDG---------------------------------------------- TH_2454|M.thermoresistible__bu PGGVGVH------------------------------------------- Mb2074c|M.bovis_AF2122/97 ---LG--------------------------------------------- Rv2048c|M.tuberculosis_H37Rv ---LG--------------------------------------------- MUL_2266|M.ulcerans_Agy99 ---LG--------------------------------------------- MAV_2450|M.avium_104 ---LG--------------------------------------------- MLBr_00135|M.leprae_Br4923 ---LG--------------------------------------------- MMAR_3798|M.marinum_M RKELGDRSVVGQLRYQVGWRNVTPNTFPQTRQRWLVLTLPEQSDDVWVAG Mflv_0405|M.gilvum_PYR-GCK -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_1003|M.vanbaalenii_PYR-1 -------------------------------------------------- TH_2454|M.thermoresistible__bu -------------------------------------------------- Mb2074c|M.bovis_AF2122/97 -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 -------------------------------------------------- MAV_2450|M.avium_104 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MMAR_3798|M.marinum_M FSARFADSVAMLAIDPHMFDRNSLAALLADEATRNKCDGVVSFMALRERT Mflv_0405|M.gilvum_PYR-GCK -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_1003|M.vanbaalenii_PYR-1 -------------------------------------------------- TH_2454|M.thermoresistible__bu -------------------------------------------------- Mb2074c|M.bovis_AF2122/97 ---------------------------------------------LAASE Rv2048c|M.tuberculosis_H37Rv ---------------------------------------------LAASE MUL_2266|M.ulcerans_Agy99 ---------------------------------------------LQAGE MAV_2450|M.avium_104 ---------------------------------------------LAAGD MLBr_00135|M.leprae_Br4923 ---------------------------------------------LGSTE MMAR_3798|M.marinum_M HQDFRGISTALLSTLHITQAYGDSGLDLPLWVITQGGAQVNPDEDLTPSQ Mflv_0405|M.gilvum_PYR-GCK ----------------------------------------------ASAG MAB_0939|M.abscessus_ATCC_1997 ----------------------------------------------GGLP MSMEG_0408|M.smegmatis_MC2_155 ----------------------------------------------GTAA Mvan_1003|M.vanbaalenii_PYR-1 -----------------------------------------------SSG TH_2454|M.thermoresistible__bu ----------------------------------------------DVDS Mb2074c|M.bovis_AF2122/97 HALLG--------------AVIDLPASGG--------------------- Rv2048c|M.tuberculosis_H37Rv HALLG--------------AVIDLPASGG--------------------- MUL_2266|M.ulcerans_Agy99 HALLG--------------AVVELPASGG--------------------- MAV_2450|M.avium_104 HALLG--------------AVVELPASGG--------------------- MLBr_00135|M.leprae_Br4923 HALLG--------------AVVERPDSGG--------------------- MMAR_3798|M.marinum_M SAVWGLGQSACLEHPTWWGGLVDLPVSPAPQDFNRLQAILTCQQSEDQLA Mflv_0405|M.gilvum_PYR-GCK SGILG--------------SGKDLASGDS--------------------- MAB_0939|M.abscessus_ATCC_1997 SGILG--------------RGEDLASGDS--------------------- MSMEG_0408|M.smegmatis_MC2_155 SGILG--------------SGKDLASGDT--------------------- Mvan_1003|M.vanbaalenii_PYR-1 SGLLG--------------SAQDLASGDI--------------------- TH_2454|M.thermoresistible__bu HTLLG--------------GRIDVAGAVP--------------------- : * : . . Mb2074c|M.bovis_AF2122/97 --------------------------------VVLTGRLSPSVQGWLADH Rv2048c|M.tuberculosis_H37Rv --------------------------------VVLTGRLSPSVQGWLADH MUL_2266|M.ulcerans_Agy99 --------------------------------VVLTGRLSLAAQGWLADH MAV_2450|M.avium_104 --------------------------------VLLTGRLSPASQGWLADH MLBr_00135|M.leprae_Br4923 --------------------------------VVLTGRLSLANQPWLADH MMAR_3798|M.marinum_M IRAAGVSARRLHKASLPQDRMRTWKISGTALVTGVTGHLGQHIARWLAQA Mflv_0405|M.gilvum_PYR-GCK ---------------------------------VYTSRLSVKTQPWLSDH MAB_0939|M.abscessus_ATCC_1997 ---------------------------------VYISRLSVRSQPWLSDH MSMEG_0408|M.smegmatis_MC2_155 ---------------------------------IYTSRLSVKSQPWLADH Mvan_1003|M.vanbaalenii_PYR-1 ---------------------------------VHTSRLSVKTQPWLSDH TH_2454|M.thermoresistible__bu -------------------------------ARVWQTRLDLSTRPYPGDH :*. : .: Mb2074c|M.bovis_AF2122/97 SVAGVTIFP----------------------------------------- Rv2048c|M.tuberculosis_H37Rv SVAGVTIFP----------------------------------------- MUL_2266|M.ulcerans_Agy99 AVGGVVIFP----------------------------------------- MAV_2450|M.avium_104 AVGGVVLFP----------------------------------------- MLBr_00135|M.leprae_Br4923 VIGGVVLFP----------------------------------------- MMAR_3798|M.marinum_M GASHLVLLSRTAAEHPQVAELEKELNSAGITTTSISVDVTDRDALAAVVA Mflv_0405|M.gilvum_PYR-GCK VIYGTVVVP----------------------------------------- MAB_0939|M.abscessus_ATCC_1997 VIYGTVVVP----------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 VIYGTVVVP----------------------------------------- Mvan_1003|M.vanbaalenii_PYR-1 VIYGTVVVP----------------------------------------- TH_2454|M.thermoresistible__bu PVQGTEIVP----------------------------------------- :.. Mb2074c|M.bovis_AF2122/97 ----GAGFVELAIRAGDEVGCGVVDELTLAAPLVLPASGSVAVQVVVNGP Rv2048c|M.tuberculosis_H37Rv ----GAGFVELAIRAGDEVGCGVVDESTLAAPLVLPASGSVAVQVVVNGP MUL_2266|M.ulcerans_Agy99 ----GAGFVELAIRAGDEVGCRVVDELTLAAPLVLPSGGSVAVQVVVGSP MAV_2450|M.avium_104 ----GAGFVELAIRAGDEVGCGIIDELNLAAPLVLPAGGSVAIQVVVDGP MLBr_00135|M.leprae_Br4923 ----GAGFVELVIRAGDEVGCAGVEELVLAAPLVLHPGSGVQVQVVVAAA MMAR_3798|M.marinum_M ETRIEHGPIHTVVHAAAHIGLVTTAETTIDEFIKSFAAKALGAENLIAVL Mflv_0405|M.gilvum_PYR-GCK ------GATYAAMALAAVGTPAHAKDVFFYEPIILPEKSSREVQLTVHPS MAB_0939|M.abscessus_ATCC_1997 ------GATYAAMALAAVGTPARAKDVFFYEPIILPEKSSREVQLTLHPL MSMEG_0408|M.smegmatis_MC2_155 ------GATYAAMALAAVGTPARLKDVFFYEPIILPEKASREVQLTLHPA Mvan_1003|M.vanbaalenii_PYR-1 ------GATYAAMALAAMPTPARVQEVFFYEPIILGDKDSREVQLMLHRT TH_2454|M.thermoresistible__bu ----------AAVLLNTFLTAAGSDIADVRLRTPVAPARTRDVQVVLQDR .: . : : Mb2074c|M.bovis_AF2122/97 DESGVRGVSVYSRGDVGTG--WVLHAEGALRA------------GSAEPT Rv2048c|M.tuberculosis_H37Rv DESGVRGVSVYSRGDVGTG--WVLHAEGALRA------------GSAEPT MUL_2266|M.ulcerans_Agy99 DDSGARAVSVYSRGDAGSD--WVLHAEGSLGS------------GSPEPA MAV_2450|M.avium_104 DDSGARAVSVFSRADAGAG--WLLHAEGVLRA------------GSAQPA MLBr_00135|M.leprae_Br4923 DESSRRAVSVYSRGDQSHGG-WLLNAEGLLEV------------DAAEAT MMAR_3798|M.marinum_M EDQPPQTFIMFSSAAATWGG-TRQGAYAAANAYIEALVTRLRGRGCRAIA Mflv_0405|M.gilvum_PYR-GCK VDGE-SKFQVHSRPYGERGAEWALNAEGVVASGVGD------SPAAAGDL MAB_0939|M.abscessus_ATCC_1997 EDGSGSKFQVHSRPYGERDVDWSLNAEGTVVTGIGDDA---EPAPEAAEP MSMEG_0408|M.smegmatis_MC2_155 DGGSVLSFQIHSRPYGERGADWSLNAEGTVDTAGSD------PDAAADEQ Mvan_1003|M.vanbaalenii_PYR-1 DDADGWTFEVHSRPYGDRDADWSRNASGTVAAGVGD--------AAPDAA TH_2454|M.thermoresistible__bu ALALASRIVGEDTTARATAG-----------------------RDTTDRD . . Mb2074c|M.bovis_AF2122/97 ADLAMWPPAGAVPVEVADGYQQLAERGYGYGPAFR-----GLTA------ Rv2048c|M.tuberculosis_H37Rv ADLAMWPPAGAVPVEVADGYQQLAERGYGYGPAFR-----GLTA------ MUL_2266|M.ulcerans_Agy99 TDLSTWPPVGAVEVENADGYQQLAERGYGYGPAFR-----GLNA------ MAV_2450|M.avium_104 TDLSAWPPVGAVPVDLGDGYEQLAERGYRYGPAFR-----GLTS------ MLBr_00135|M.leprae_Br4923 VDLSLWPPEGAESVDISDAYPQLAERGYAYGPAFQ-----GLVA------ MMAR_3798|M.marinum_M PAWGAWTDDRTTTQEVVGYFSRIGLNQISPDIAFA-----ALQQSLDVDD Mflv_0405|M.gilvum_PYR-GCK EDPVDEAIERLNRMRPQELFETFADLELAWGPTWS-----GSLKS----- MAB_0939|M.abscessus_ATCC_1997 AEPVDAAIERMERMRPMELFEIFADLELAWGPTWS-----GSLKS----- MSMEG_0408|M.smegmatis_MC2_155 SDPVDEVIERLERMRPQDLFETFADLELAWGPTWS-----GSLKS----- Mvan_1003|M.vanbaalenii_PYR-1 ADPVDNAIERLTRTRPQQLFDAFADNDLAWGPAWC-----SSLRS----- TH_2454|M.thermoresistible__bu TTACDTTDRDTTACDDPGVWLTHCTARVADDHVGAEGVLD---------- : . . Mb2074c|M.bovis_AF2122/97 --------MWRRGDEVFAEV----ALPADAGVSVTGFGVHPVLLDAALHA Rv2048c|M.tuberculosis_H37Rv --------MWRRGDEVFAEV----ALPADAGVSVTGFGVHPVLLDAALHA MUL_2266|M.ulcerans_Agy99 --------MWRRGDEVFAEV----ALPADAGVSVSGFGIHPVMLDAALHA MAV_2450|M.avium_104 --------MWRRGDEIFAEV----NLPTDAGVSTTGFGVHPVMLDAALHA MLBr_00135|M.leprae_Br4923 --------IWRRGSELFAEV----VAPT--GVVVDGMGMHPALLDAVLHA MMAR_3798|M.marinum_M TLITIADVDWSQFRDVFTTTGRAHALLAELGTSQPQTAEIPAIAENSHFA Mflv_0405|M.gilvum_PYR-GCK --------LWLGEGEAIGDILVGAELAEQLGTEPMHPVLMDLCTGVAFPA MAB_0939|M.abscessus_ATCC_1997 --------LWLGEGEAIGDVLVGEELAEQLGTEPMHPVLMDLCTGVAFPA MSMEG_0408|M.smegmatis_MC2_155 --------LWLGDGEAVGDILVGAELAEQLGSEPMHPVLMDLCTGVAFPA Mvan_1003|M.vanbaalenii_PYR-1 --------LWVGTGEAVGDIAVGAELGEHLGREPIHPVLLDLCTGIAGAA TH_2454|M.thermoresistible__bu ----------------------EEAIRARCPQPLPAGHVVDTLAGLG--- Mb2074c|M.bovis_AF2122/97 VVLSAESAERG--------------------------------------- Rv2048c|M.tuberculosis_H37Rv VVLSAESAERG--------------------------------------- MUL_2266|M.ulcerans_Agy99 VILASDGADDFGV------------------------------------- MAV_2450|M.avium_104 VMLASDGDDLP--------------------------------------- MLBr_00135|M.leprae_Br4923 LGLAIENTQAT--------------------------------------- MMAR_3798|M.marinum_M AQLAKQAPQQQLATLIGLVTNVTAAVLAHPDPAVLDPDLSFKDLGIDSLS Mflv_0405|M.gilvum_PYR-GCK FPALLAA-EQG--------------------------------------- MAB_0939|M.abscessus_ATCC_1997 FPALLAA-EQG--------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 FPALLAA-EQG--------------------------------------- Mvan_1003|M.vanbaalenii_PYR-1 LLAAAAQ-TDA--------------------------------------- TH_2454|M.thermoresistible__bu -------------------------------------------------- Mb2074c|M.bovis_AF2122/97 -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 -------------------------------------------------- MAV_2450|M.avium_104 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MMAR_3798|M.marinum_M ALELRNTLTRDTGLTLPATVVFDHPTPTAVAEHLLGLLSGVTGPTLAVVP Mflv_0405|M.gilvum_PYR-GCK -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_1003|M.vanbaalenii_PYR-1 -------------------------------------------------- TH_2454|M.thermoresistible__bu -------------------------------------------------- Mb2074c|M.bovis_AF2122/97 -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 -------------------------------------------------- MAV_2450|M.avium_104 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MMAR_3798|M.marinum_M TRVGVDVPVAVVGMACRLPGGIESAAGLWDVVSNGIDVMSGFPLDRGWDV Mflv_0405|M.gilvum_PYR-GCK -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_1003|M.vanbaalenii_PYR-1 -------------------------------------------------- TH_2454|M.thermoresistible__bu -------------------------------------------------- Mb2074c|M.bovis_AF2122/97 ---------------------------------------------QGSVL Rv2048c|M.tuberculosis_H37Rv ---------------------------------------------QGSVL MUL_2266|M.ulcerans_Agy99 --------------------------------------------PEGSVL MAV_2450|M.avium_104 ---------------------------------------------AGSML MLBr_00135|M.leprae_Br4923 ----------------------------------------------TEMR MMAR_3798|M.marinum_M AGLFDPDPDAEGKTYTRYGGFVADVAGFDAEFFGISAREAITMDPQQRVL Mflv_0405|M.gilvum_PYR-GCK ---------------------------------------------VNDLY MAB_0939|M.abscessus_ATCC_1997 ---------------------------------------------VNDLF MSMEG_0408|M.smegmatis_MC2_155 ---------------------------------------------VNDLF Mvan_1003|M.vanbaalenii_PYR-1 ---------------------------------------------DPELF TH_2454|M.thermoresistible__bu -----------------------------------------------VAA Mb2074c|M.bovis_AF2122/97 VPFSWQGVSLHAAGASAVRAR------------------------IAPVG Rv2048c|M.tuberculosis_H37Rv VPFSWQGVSLHAAGASAVRAR------------------------IAPVG MUL_2266|M.ulcerans_Agy99 VPFAWQGVTLHAAGASAVRAR------------------------IAPAG MAV_2450|M.avium_104 VPFSWQRVSLHAAGAAAVRAR------------------------IVPVS MLBr_00135|M.leprae_Br4923 LPFCWRGVSLHAGGAGRVRAR------------------------FTSAG MMAR_3798|M.marinum_M LEVCWQALEHAGIDPTTLEGSDTGVFVGIGAQSYVSGHSGVEGYALTGAS Mflv_0405|M.gilvum_PYR-GCK LPLRYGQVSLQEKMPRRFYCRATWHEAPLDSETQVFDLEYLDRDGRHLGG MAB_0939|M.abscessus_ATCC_1997 LPLRYGQVTLKEKMPRRFYCRARWHESPLDSETQVFDLDYLDRDGRHLGG MSMEG_0408|M.smegmatis_MC2_155 LPLRYGQVTLAEKMPRRFYCRARWHRSALDSETQVFELEFVDLGGRALGG Mvan_1003|M.vanbaalenii_PYR-1 LPLRYGRVEVRERMPRRFYCRARWQTGGIDSETQVFDLDFLDHDGRNLGG TH_2454|M.thermoresistible__bu MGFGWEVLELHR-------------------------------------- : . : : Mb2074c|M.bovis_AF2122/97 PSAVSIELADGLGLP-------VLSVASMLARPVTDQQLR---------- Rv2048c|M.tuberculosis_H37Rv PSAVSIELADGLGLP-------VLSVASMLARPVTDQQLR---------- MUL_2266|M.ulcerans_Agy99 PSAVSIELSDGLGLP-------VLSVASMLARPVTDQQLR---------- MAV_2450|M.avium_104 PSAVSIELADGLGLP-------VLSVASMVARPVTDQQLL---------- MLBr_00135|M.leprae_Br4923 ADAIAVDIADSAGLP-------VLTVRSLVTRAMTAEQLR---------- MMAR_3798|M.marinum_M ASVASGRVAYVLGLQGPAITVDTACSSSLVATHLACQSLRNGESSLALAG Mflv_0405|M.gilvum_PYR-GCK VREFTVKRAPREALLRG-----LGGDATRLLYTLGWHEVPVP-------- MAB_0939|M.abscessus_ATCC_1997 IREFTVKRAPREALLRG-----LGGDATRLLYTLGWHEVAVPPVA----- MSMEG_0408|M.smegmatis_MC2_155 IREFTVKRAPREALLRG-----LGGDATRLLYTLGWHEVPPP-------- Mvan_1003|M.vanbaalenii_PYR-1 IREFTVKRAPREALLRG-----LGADATRLIYRVGWRETSPP-------- TH_2454|M.thermoresistible__bu -------------------------------------------------- Mb2074c|M.bovis_AF2122/97 ----------------------------AAVSSSG---PDRLFEVTWSPQ Rv2048c|M.tuberculosis_H37Rv ----------------------------AAVSSSG---PDRLFEVTWSPQ MUL_2266|M.ulcerans_Agy99 ----------------------------AAVSGAG---PDRLFGVDWTAQ MAV_2450|M.avium_104 ----------------------------AAVSNSG---PDRLFELIWSAQ MLBr_00135|M.leprae_Br4923 ----------------------------TAVTAAGGALEQGPMDLVWSPI MMAR_3798|M.marinum_M GATIMATPTPFIEFARQRGLAADGRCKAFAAAADGTGWGEGAAVLVLERL Mflv_0405|M.gilvum_PYR-GCK -------------------------ESGDGAAPQGTWLIGGFDELAVSVP MAB_0939|M.abscessus_ATCC_1997 ------------------------GEGEESAASIGTWLIAGFDELAAKVP MSMEG_0408|M.smegmatis_MC2_155 ---------------------------PSADDAVGTWLIAGFDELAAKVP Mvan_1003|M.vanbaalenii_PYR-1 ------------------------VRDDGALGPSSTWLVAGLDALADDVP TH_2454|M.thermoresistible__bu -------------------------------------------------- Mb2074c|M.bovis_AF2122/97 PSAAVEP-----------LPVCAWGTTEDS-------------AAVVFES Rv2048c|M.tuberculosis_H37Rv PSAAVEP-----------LPVCAWGTTEDS-------------AAVVFES MUL_2266|M.ulcerans_Agy99 PSAELQP-----------VPVRIWGTVESEGDDDPG-------ASVVFES MAV_2450|M.avium_104 PSTAVQP-----------VSLLNWGATELDATDTDSDS---GRFAVLFES MLBr_00135|M.leprae_Br4923 PLSSDGHG-------GGLPSVVSWADYCAGRGNDTG--------VVVWEF MMAR_3798|M.marinum_M SDARRNRH-------PVLAVIAGSAVNQDGASNGLSAPNGPAQQRVISQA Mflv_0405|M.gilvum_PYR-GCK GCIPADR----------------TNPESLRQLLTDAHGRGLPFSGVVWRA MAB_0939|M.abscessus_ATCC_1997 GCIPLNRE---------------TDPELLGEVLVAAKERGVPFSGVVWRA MSMEG_0408|M.smegmatis_MC2_155 GCVPIDRN---------------TDLQVLGEVLSQAHARGAGFSGVVWRC Mvan_1003|M.vanbaalenii_PYR-1 GSIRIGFDRIWDPDRDGRVVLDPADDEHWRRLFALADERRAPVAGVVLGV TH_2454|M.thermoresistible__bu -------------------------------------------------- Mb2074c|M.bovis_AF2122/97 VPLAG------DVVAGVYAATSS--------------------------- Rv2048c|M.tuberculosis_H37Rv VPLAG------DVVAGVYAATSS--------------------------- MUL_2266|M.ulcerans_Agy99 VPQAG------EVVAGVYAATAA--------------------------- MAV_2450|M.avium_104 APVAG------DVVTEVYAATRA--------------------------- MLBr_00135|M.leprae_Br4923 GSASAGAQAPVDSVAAVYSATHA--------------------------- MMAR_3798|M.marinum_M LANAGLPFTHVDVVEAHGTGTTLGDPIEAGALIATYGTHRDPEHPLWLGS Mflv_0405|M.gilvum_PYR-GCK ARSDGDES--DAEVAARLEAEIA--------------------------- MAB_0939|M.abscessus_ATCC_1997 AGPGATES--TTESAARLEGEIA--------------------------- MSMEG_0408|M.smegmatis_MC2_155 ATPGRKESGSASAESARLEAEIT--------------------------- Mvan_1003|M.vanbaalenii_PYR-1 TGRARPEE-PSADFAARLEAQIR--------------------------- TH_2454|M.thermoresistible__bu -------------------------------------------------- Mb2074c|M.bovis_AF2122/97 -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 -------------------------------------------------- MAV_2450|M.avium_104 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MMAR_3798|M.marinum_M VKSNIGHTQHAAGAAGLIKMIQALNHAVLPATLHIDQPSPHIDWSTDTVR Mflv_0405|M.gilvum_PYR-GCK -------------------------------------------------E MAB_0939|M.abscessus_ATCC_1997 -------------------------------------------------H MSMEG_0408|M.smegmatis_MC2_155 -------------------------------------------------N Mvan_1003|M.vanbaalenii_PYR-1 -------------------------------------------------D TH_2454|M.thermoresistible__bu -------------------------------------------------- Mb2074c|M.bovis_AF2122/97 VLDVLQSWLT-----RDGAGVLVVMTRGAVALPGEDVTDLAGAAVWGLVR Rv2048c|M.tuberculosis_H37Rv VLDVLQSWLT-----RDGAGVLVVMTRGAVALPGEDVTDLAGAAVWGLVR MUL_2266|M.ulcerans_Agy99 VLEVLRSWLS-----RDGAGQLIITTRGAVALPDEDVTDLAGSAVWGLVR MAV_2450|M.avium_104 VLPVLQSWLA-----RDGAGTLVVSTRGAMTLPGEDVTDLAGAAVWGLVR MLBr_00135|M.leprae_Br4923 ALQVLQFWFG-----QDRAGTLVVLTRGAVGLVGEGISDLAAAAVWGMVR MMAR_3798|M.marinum_M LLTEATPWPE-----TEHLRTGAVSAFGVSGTNAHLIVQQAPPEVFESVP Mflv_0405|M.gilvum_PYR-GCK LLGAVHTVQ---GGEVKLPGGLWIVTERAVATESGEPVDPVQAALWGFGR MAB_0939|M.abscessus_ATCC_1997 LLSAVHTVQNSAQNGVKLPGGLWIVTERAVATESGEPVDPVQAALWGFGR MSMEG_0408|M.smegmatis_MC2_155 LLSAVHAAQ---GPSVKLPGGLWIVTEHGVACESGEPVDPVQAALWGFGR Mvan_1003|M.vanbaalenii_PYR-1 VLGAVHSLS---ALGAKPAAGLWIVTERAVAAEAGEPVDPVQSALWGLGR TH_2454|M.thermoresistible__bu -------------------------GEGELFARVAAEPDKSAPATWAGLI : . : Mb2074c|M.bovis_AF2122/97 SAQTEHPG------------------------------------------ Rv2048c|M.tuberculosis_H37Rv SAQTEHPG------------------------------------------ MUL_2266|M.ulcerans_Agy99 SAQTEHPG------------------------------------------ MAV_2450|M.avium_104 SAQTEHPG------------------------------------------ MLBr_00135|M.leprae_Br4923 SAQSEHSG------------------------------------------ MMAR_3798|M.marinum_M EPETARPSGQPLLRIWPVSAHTPAALTAQAERLSEYLTRHEDLSLTDLAY Mflv_0405|M.gilvum_PYR-GCK TAINEEPA------------------------------------------ MAB_0939|M.abscessus_ATCC_1997 TTINEEPA------------------------------------------ MSMEG_0408|M.smegmatis_MC2_155 TTINEEPA------------------------------------------ Mvan_1003|M.vanbaalenii_PYR-1 TLIAEEPG------------------------------------------ TH_2454|M.thermoresistible__bu DAATSTAS------------------------------------------ .. Mb2074c|M.bovis_AF2122/97 -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 -------------------------------------------------- MAV_2450|M.avium_104 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MMAR_3798|M.marinum_M SLACTRTHHPYRAAVTVPVDTSNPGHDLAAALRALAANQPHPYVTCHHYR Mflv_0405|M.gilvum_PYR-GCK -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_1003|M.vanbaalenii_PYR-1 -------------------------------------------------- TH_2454|M.thermoresistible__bu -------------------------------------------------- Mb2074c|M.bovis_AF2122/97 -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 -------------------------------------------------- MAV_2450|M.avium_104 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MMAR_3798|M.marinum_M ARQPSKTVFVFPGQGGQYPAMAAELYRQHPGFATAVDECDAELRPYTGWS Mflv_0405|M.gilvum_PYR-GCK -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_1003|M.vanbaalenii_PYR-1 -------------------------------------------------- TH_2454|M.thermoresistible__bu -------------------------------------------------- Mb2074c|M.bovis_AF2122/97 ------------------------------------------RIVLVDSD Rv2048c|M.tuberculosis_H37Rv ------------------------------------------RIVLVDSD MUL_2266|M.ulcerans_Agy99 ------------------------------------------RIVLVDTD MAV_2450|M.avium_104 ------------------------------------------RIVLVDTD MLBr_00135|M.leprae_Br4923 ------------------------------------------KIVLIDTD MMAR_3798|M.marinum_M VRDVICQDPDAPSLELVEVIQPVLFAVMIALAETLRGYGIVPDAVIGHSQ Mflv_0405|M.gilvum_PYR-GCK -----------------------------------------LRCRLVDCD MAB_0939|M.abscessus_ATCC_1997 -----------------------------------------LRAKLVDGD MSMEG_0408|M.smegmatis_MC2_155 -----------------------------------------LHCRLVDCD Mvan_1003|M.vanbaalenii_PYR-1 -----------------------------------------LRCLLVDLD TH_2454|M.thermoresistible__bu --------------------------------------------TIFDGP : . Mb2074c|M.bovis_AF2122/97 APLDDSALAAVVTTGE----PQVLWRRGEVYTARVHGSRAVGGLLVPPSD Rv2048c|M.tuberculosis_H37Rv APLDDSALAAVVTTGE----PQVLWRRGEVYTARVHGSRAVGGLLVPPSD MUL_2266|M.ulcerans_Agy99 AQLDEHAVAAVLAAGE----PQVLWRNGEVYTARVHGSRAVAGLLVPPGD MAV_2450|M.avium_104 APLDADAVAAVLAVGE----PQTLLRNGTVYTARVLGSRAVGALLVPPED MLBr_00135|M.leprae_Br4923 SAVD---VAVLADLGE----SQLLVRCNTVHAARLS--PAPQLLALPVGE MMAR_3798|M.marinum_M GEIAAAYIAGALTLAE----AAKVVALRSAALAQLAGTGTMASVLLSPEE Mflv_0405|M.gilvum_PYR-GCK GSPQAVQALAALLSTP-VDEPELAVRQGKLLASRLLPWSRSGHLTVPRGG MAB_0939|M.abscessus_ATCC_1997 GSPEAVQALARLLVTP-VDEPEIAVRQGKLLASRLLPWSRTGHLTVPRGS MSMEG_0408|M.smegmatis_MC2_155 GSSEAVDLLAALLAAPGIQEPEIAVRQGKLLASRLLPWARSGHLTLPRGG Mvan_1003|M.vanbaalenii_PYR-1 GSEDAGPALARLLGAP-GDEPELALRQGRLLVPRLLPWSRSGQLAIPRGT TH_2454|M.thermoresistible__bu PRLRMPARIERVHVRD-------KPPAIALLHVRRRPEGTVTDVTIAEES : : :. Mb2074c|M.bovis_AF2122/97 R-----PWRLAMSTA---------------------GTFEN--------- Rv2048c|M.tuberculosis_H37Rv R-----PWRLAMSTA---------------------GTFEN--------- MUL_2266|M.ulcerans_Agy99 G-----PWRLGMSTA---------------------GTFEN--------- MAV_2450|M.avium_104 G-----PWRLGMSSY---------------------GTIEN--------- MLBr_00135|M.leprae_Br4923 S-----MWRLAADGG---------------------GTLED--------- MMAR_3798|M.marinum_M LRPLLQPWNTQISIAAINGPAHTIISGDTTAVEQFIGTCEDGGVQIRPIA Mflv_0405|M.gilvum_PYR-GCK D------YVLAPTER---------------------GAIDN--------- MAB_0939|M.abscessus_ATCC_1997 D------YVLAPTER---------------------GAIDN--------- MSMEG_0408|M.smegmatis_MC2_155 D------FVLAPTER---------------------GAIDN--------- Mvan_1003|M.vanbaalenii_PYR-1 D------YVLAPTER---------------------GVLDN--------- TH_2454|M.thermoresistible__bu G------------------------------------------------- Mb2074c|M.bovis_AF2122/97 -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 -------------------------------------------------- MAV_2450|M.avium_104 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MMAR_3798|M.marinum_M VDYASHSAHVERLREHLLHELADLNPQPARIPLYSTVASELSEHPLDTTA Mflv_0405|M.gilvum_PYR-GCK -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_1003|M.vanbaalenii_PYR-1 -------------------------------------------------- TH_2454|M.thermoresistible__bu -------------------------------------------------- Mb2074c|M.bovis_AF2122/97 -------------------------------LRLELIPDADAPLG---PG Rv2048c|M.tuberculosis_H37Rv -------------------------------LRLELIPDADAPLG---PG MUL_2266|M.ulcerans_Agy99 -------------------------------LRLEPIPDADAALQ---PG MAV_2450|M.avium_104 -------------------------------LRLEPIPDADAPLG---PG MLBr_00135|M.leprae_Br4923 -------------------------------LVIQPCPEVQAPLQ---AG MMAR_3798|M.marinum_M MDAEYWYRNLREPVEFYSCVAQLLAHSERVFVELSPHPVLASALTDALAD Mflv_0405|M.gilvum_PYR-GCK -------------------------------LRLTDSEVPPPAEG----- MAB_0939|M.abscessus_ATCC_1997 -------------------------------LRITEKEVPAPDEG----- MSMEG_0408|M.smegmatis_MC2_155 -------------------------------LRLTETDVPEPDEG----- Mvan_1003|M.vanbaalenii_PYR-1 -------------------------------LRVSETEVTAPPEG----- TH_2454|M.thermoresistible__bu -------------------------------------------------- Mb2074c|M.bovis_AF2122/97 QVRVAVSAIAANFR-------DVMIALG---------------LYP---- Rv2048c|M.tuberculosis_H37Rv QVRVAVSAIAANFR-------DVMIALG---------------LYP---- MUL_2266|M.ulcerans_Agy99 HVRVALSAMAANFR-------DVMIALG---------------LYP---- MAV_2450|M.avium_104 QVRVATSALAANFR-------DVMIALG---------------LYP---- MLBr_00135|M.leprae_Br4923 HMRVAVAAVGVNFR-------DVVAALG---------------MYP---- MMAR_3798|M.marinum_M TGQLTQSAVVTTLRRDRPDMDMVASAIANLHVHGHSPSWQ--KIYPGATT Mflv_0405|M.gilvum_PYR-GCK YVQVRVEAAGLNFR-------DVLNVLG-----------LYP-------- MAB_0939|M.abscessus_ATCC_1997 YVQVRVEAAGLNFR-------DVLNVLG-----------LYP-------- MSMEG_0408|M.smegmatis_MC2_155 YVQVRVEAAGLNFR-------DVLNVLG-----------LYP-------- Mvan_1003|M.vanbaalenii_PYR-1 HVQVRVEAAGLNFR-------DVLNALG-----------LYP-------- TH_2454|M.thermoresistible__bu --AVSVTLTGMGFE------------------------------------ : :. Mb2074c|M.bovis_AF2122/97 ---------------DPDAVMGVEACG----------VVIETSLNKGSFA Rv2048c|M.tuberculosis_H37Rv ---------------DPDAVMGVEACG----------VVIETSLNKGSFA MUL_2266|M.ulcerans_Agy99 ---------------DPDAAMGVEGAG----------VVVETASPDGRFA MAV_2450|M.avium_104 ---------------DPDAVMGIEASG----------VVIETASQDGRVA MLBr_00135|M.leprae_Br4923 ---------------GQAPPLGAEGAG----------VVIEIGPEVTGVA MMAR_3798|M.marinum_M VELPTYPFQHRRYWLDPAPRADVSAAGLDQPEHPLLAAVTELADQDQIVL Mflv_0405|M.gilvum_PYR-GCK ---------------GDPGPIGGDFAG----------TVTQLGEGVTGLD MAB_0939|M.abscessus_ATCC_1997 ---------------GDPGPIGGDFAG----------IVTQLGEGVTGVE MSMEG_0408|M.smegmatis_MC2_155 ---------------GDPGPIGGDFAG----------TVTQLGAGVSGLE Mvan_1003|M.vanbaalenii_PYR-1 ---------------GDPGPIGGELAG----------VVTAPGPDVDGFD TH_2454|M.thermoresistible__bu ---------------ELENPGGGGSSG----------------------- . .* Mb2074c|M.bovis_AF2122/97 VG------------------------DRVMGLFPEGTGTVASTDQRLLVK Rv2048c|M.tuberculosis_H37Rv VG------------------------DRVMGLFPEGTGTVASTDQRLLVK MUL_2266|M.ulcerans_Agy99 VG------------------------DRVVGLFPEGTGTIAITDHRLLVK MAV_2450|M.avium_104 VG------------------------DRVMGLFPDGTGTVATTDQRLLVK MLBr_00135|M.leprae_Br4923 VG------------------------DAVMG-FLGGAGPLAVVHQQLITQ MMAR_3798|M.marinum_M SGRLSTSAHRWLAGHQLGDTVVLPATALIDMALYAGEHTGCPTIDELVLQ Mflv_0405|M.gilvum_PYR-GCK VG------------------------QRVYGSMQGAFASRFNVPGQFLAP MAB_0939|M.abscessus_ATCC_1997 VG------------------------QRVYGSMQGAFGSRFNVPAQFLAP MSMEG_0408|M.smegmatis_MC2_155 IG------------------------QRVYGSMQGAFASRFNVPAQFLAP Mvan_1003|M.vanbaalenii_PYR-1 VG------------------------QRVFGFAVGAFASRVNVPVQFLAP TH_2454|M.thermoresistible__bu -----------------------------------DLTGMLHHLRWHPVD Mb2074c|M.bovis_AF2122/97 VPAGWSHTAAATTSVVFATAHYALVDLADVQPGQRVLIHAGTGGVGMAAV Rv2048c|M.tuberculosis_H37Rv VPAGWSHTAAATTSVVFATAHYALVDLAAARSGQRVLIHAGTGGVGMAAV MUL_2266|M.ulcerans_Agy99 IPAGWSDTAAATTSVVFATAFYALRDLASVQPGQRILVHAATGGVGMAAV MAV_2450|M.avium_104 VPAGWSHTAAATASVVFATAYYALVDLADARPGQRVLVHAAAGGVGMAAV MLBr_00135|M.leprae_Br4923 MPQGWSLAEAAAVPVVFLTALFGLADLAGIRAGESVLIHAGTGGVGMAAV MMAR_3798|M.marinum_M TPLTLTPDAATDLQISVAAPDEQNRRTFSVHARTSEHPHQHSTWVLHASG Mflv_0405|M.gilvum_PYR-GCK IPDGVSAVEAATIPAAALTVR-LSFDWAQVKSGDKVLIHAASGGVGLAAV MAB_0939|M.abscessus_ATCC_1997 IPDGISGVEAATIPAAALTVR-LSFDWAQLKPGDKVLIHAASGGVGLAAI MSMEG_0408|M.smegmatis_MC2_155 IPDGIGAVEAATIPAAALTVR-LAFDWAQLKPGDKVLIHAASGGVGLAAI Mvan_1003|M.vanbaalenii_PYR-1 VPEGISAVAAATTPAAVLTAG-LAFDWAALRAGDRVLIHAASGGVGLAAV TH_2454|M.thermoresistible__bu WPDTDPPAAVVLVGGDARTRAFVTRDLDEARVAHRSYADPAALPPDLTAG * .. : : . : :: Mb2074c|M.bovis_AF2122/97 QLARHLG-----------------------LEVFATASKGKWDTLRAMGF Rv2048c|M.tuberculosis_H37Rv QLARHLG-----------------------LEVFATASKGKWDTLRAMGF MUL_2266|M.ulcerans_Agy99 QLARHWG-----------------------LEVFATASKGKWDTLRAMGF MAV_2450|M.avium_104 QLARHLG-----------------------LEVFATASRGKWDTLRDMGF MLBr_00135|M.leprae_Br4923 QFARHWG-----------------------VEIFVTASRGKWDTLRDMGF MMAR_3798|M.marinum_M TLSNHPSRMFSPTTPFAAGRTPNAVDQDSFYEELAQHGVRYDGAFRALHS Mflv_0405|M.gilvum_PYR-GCK QMAQQCG-----------------------AEVYATASTFKRATLRKLGV MAB_0939|M.abscessus_ATCC_1997 QMAQQFG-----------------------AEVFATASTFKRATLRKLGV MSMEG_0408|M.smegmatis_MC2_155 QMAQQSG-----------------------AEVFATASTFKRSTLRRLGV Mvan_1003|M.vanbaalenii_PYR-1 QLARQRG-----------------------ATVFATASGYKRPMLRAMGV TH_2454|M.thermoresistible__bu TVVLVLP------------------------RTAARPAASAQLVLHTLQR . . . :: : Mb2074c|M.bovis_AF2122/97 DDDHISDSRSLEFEDKFRAATGGRG-------FDVVLDSLAGE-FVDAS- Rv2048c|M.tuberculosis_H37Rv DDDHISDSRSLEFEDKFRAATGGRG-------FDVVLDSLAGE-FVDAS- MUL_2266|M.ulcerans_Agy99 DEDHIGDSRSLEFEDKFRAATGGRG-------MDVVLDSLAGE-FVDAS- MAV_2450|M.avium_104 DDDHLGDSRGLDFEDKFRAVTGGAG-------MDIVLDSLSGD-SVDAS- MLBr_00135|M.leprae_Br4923 DDDHIGDSRTLEFEEKFLAVTDGRG-------VDVVLDSLAGD-FVDAS- MMAR_3798|M.marinum_M LENNPSDTDTTCAEVALPADTDVDGYGIHPALLDAALQPLAAA-FTDTDT Mflv_0405|M.gilvum_PYR-GCK K--HVYDSRTTDFAEQILADTDGAG-------VDVVLNSLTSEGFIEAT- MAB_0939|M.abscessus_ATCC_1997 K--YVYDSRTTDFADQILADTDGAG-------VDVVLNSLTSEGFIEAT- MSMEG_0408|M.smegmatis_MC2_155 K--YVYDSRTTDFADQILADTNGAG-------VDVVLNSLTSAGFVEAT- Mvan_1003|M.vanbaalenii_PYR-1 D--HVYDSRTTDFADQILADTDGAG-------VDVVLNSLTNDGFVAAT- TH_2454|M.thermoresistible__bu LSATNSGARLWVLTRGVHEGTDPGHG---------PLWGLARVAAAEHP- .: . *. * *: Mb2074c|M.bovis_AF2122/97 ----------------------------LRLVAPGGVFLEMGKTDIRDPG Rv2048c|M.tuberculosis_H37Rv ----------------------------LRLVAPGGVFLEMGKTDIRDPG MUL_2266|M.ulcerans_Agy99 ----------------------------LRLVAPGGVFLEMGKTDIREAA MAV_2450|M.avium_104 ----------------------------LRLVAPGGIFLEMGKTDIRDPE MLBr_00135|M.leprae_Br4923 ----------------------------LRLLVRGGRFLEMGKTDIRDAQ MMAR_3798|M.marinum_M DAPSAATPRMPFVITGVNLHATGARRLLVQLTATDADTFSLHATDPAGAT Mflv_0405|M.gilvum_PYR-GCK ----------------------------LRATAQHGRFAEIAKRDIWTVE MAB_0939|M.abscessus_ATCC_1997 ----------------------------LRATAKNGRFAEIAKRDIWTTE MSMEG_0408|M.smegmatis_MC2_155 ----------------------------LKATAQGGRFAEIAKRDIWSHE Mvan_1003|M.vanbaalenii_PYR-1 ----------------------------VRATARNGRFAEIAKRDIWSPE TH_2454|M.thermoresistible__bu --------------------------------QLWGGLLDIGEDRLPVRA . .: Mb2074c|M.bovis_AF2122/97 VIAQQYPGVR-------YRAFDLFEAGPDRIAQILAELATLFGDGVLRPL Rv2048c|M.tuberculosis_H37Rv VIAQQYPGVR-------YRAFDLFEPGPDRIAQILAELATLFGDGVLRPL MUL_2266|M.ulcerans_Agy99 VVAQQHTGVR-------YRAFDLFEAGPDHIAQILAELAALFSEDVLRPL MAV_2450|M.avium_104 VVAAEHPGVR-------YRAFDLFEAGPDRIARLLDELAAMFGEDVLRPL MLBr_00135|M.leprae_Br4923 EIAANYPGVQ-------YRAFDLSEAGPVRMQEMLCEVRELFDTQVLHRL MMAR_3798|M.marinum_M VITINAVTLRALTDIGSLRTSGISRRGLLELAWPALPPDTFSTAAVLPPL Mflv_0405|M.gilvum_PYR-GCK QMAAARPDLAY----EIVALDTVMFTEPDRIRDLLTEVSAGLRDGAWTPL MAB_0939|M.abscessus_ATCC_1997 QMAQSRPDIAY----EIVALDTVMFQEPDRIRVLLTEVSEGLAKGEWTPL MSMEG_0408|M.smegmatis_MC2_155 QMAEARPDIAY----EIVALDTVMFTEPDRIRDLLTEVSDGMARGEWTPL Mvan_1003|M.vanbaalenii_PYR-1 QMAAARPDIDY----EVLALDAVMQQDPDRIQLLLADLADSLARGETAPL TH_2454|M.thermoresistible__bu LTALTG-------------HGVVVVRDGVAHTARLAPAGPGARDSAGEGL : : * Mb2074c|M.bovis_AF2122/97 PVTT---------------------------------FDVRRAP------ Rv2048c|M.tuberculosis_H37Rv PVTT---------------------------------FDVRCAP------ MUL_2266|M.ulcerans_Agy99 PVTT---------------------------------FDVRRAP------ MAV_2450|M.avium_104 PVTR---------------------------------FDVRRAP------ MLBr_00135|M.leprae_Br4923 PVTS---------------------------------WDVRCAP------ MMAR_3798|M.marinum_M ALVSSHSDDLAHALGQSSQCTVYTDLAAVQPCPPLVLWDLTAGPDPTPTP Mflv_0405|M.gilvum_PYR-GCK PAEV-------------------------YPLTEAR-------------- MAB_0939|M.abscessus_ATCC_1997 PAEI-------------------------YPLTEAR-------------- MSMEG_0408|M.smegmatis_MC2_155 PAEI-------------------------YPITEAR-------------- Mvan_1003|M.vanbaalenii_PYR-1 PFEA-------------------------YPLAEAT-------------- TH_2454|M.thermoresistible__bu RCSP---------------------------------------------- Mb2074c|M.bovis_AF2122/97 -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv -------------------------------------------------- MUL_2266|M.ulcerans_Agy99 -------------------------------------------------- MAV_2450|M.avium_104 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MMAR_3798|M.marinum_M EDGDTEDPLQRVHTLTRHTLAGLQNWLNRSDTTGTHLVILTRRAVTTVPD Mflv_0405|M.gilvum_PYR-GCK -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_1003|M.vanbaalenii_PYR-1 -------------------------------------------------- TH_2454|M.thermoresistible__bu -------------------------------------------------- Mb2074c|M.bovis_AF2122/97 -----------AALRYLSQARHTGKVVMLMP------------------- Rv2048c|M.tuberculosis_H37Rv -----------AALRYLSQARHTGKVVMLMP------------------- MUL_2266|M.ulcerans_Agy99 -----------AALRYLSQARHVGKVVLTMP------------------- MAV_2450|M.avium_104 -----------AALRYLSQARHVGKVVMTMP------------------- MLBr_00135|M.leprae_Br4923 -----------AAFRFMSQARHIGKVVLTMPS------------------ MMAR_3798|M.marinum_M DRSPDPAHAATWAFAHSAQNEHPNRITLIDIDNTPATSQTLTNILTTLTN Mflv_0405|M.gilvum_PYR-GCK -----------AAFRRMQQARHIGKIVVQIPN------------------ MAB_0939|M.abscessus_ATCC_1997 -----------TAFRRMQQARHIGKIVCQMPN------------------ MSMEG_0408|M.smegmatis_MC2_155 -----------SAFRRMQQARHIGKIVLQVPK------------------ Mvan_1003|M.vanbaalenii_PYR-1 -----------TAFRRMQQARHTGKIILQMPK------------------ TH_2454|M.thermoresistible__bu -------------------------------------------------- Mb2074c|M.bovis_AF2122/97 ------------------------------------GSWAAGTVLITGGT Rv2048c|M.tuberculosis_H37Rv ------------------------------------GSWAAGTVLITGGT MUL_2266|M.ulcerans_Agy99 ------------------------------------DAWAAGTVLITGGT MAV_2450|M.avium_104 ------------------------------------DAWTAGTVLITGAT MLBr_00135|M.leprae_Br4923 ---------------------------------ALADGLAEGTVLITGAS MMAR_3798|M.marinum_M PTSAPTEPQLALRHGTPHTPRLTPTTTETTTTSPPLEFDPAGTVLITGGT Mflv_0405|M.gilvum_PYR-GCK ----------------------------------PLQPQPDRSYLITGGL MAB_0939|M.abscessus_ATCC_1997 ----------------------------------PLAPRPDRTYLITGGL MSMEG_0408|M.smegmatis_MC2_155 ----------------------------------PLQPQQDRSYLITGGL Mvan_1003|M.vanbaalenii_PYR-1 ----------------------------------PLQPHGDRSYLITGGL TH_2454|M.thermoresistible__bu ----------------------------------------GGTYLITGGT : ****. Mb2074c|M.bovis_AF2122/97 GMAGSAVARHVVARHGVRNLVLVSRRGPDA---------PGAAELVAELA Rv2048c|M.tuberculosis_H37Rv GMAGSAVARHVVARHGVRNLVLVSRRGPDA---------PGAAELVAELA MUL_2266|M.ulcerans_Agy99 GMAGSALARHVVAHHGVRQLVLVSRRGPDA---------PGAAELAEELS MAV_2450|M.avium_104 GMAGSAVARHVVTRHGARNLVLVSRRGLDA---------PDAAELVAELT MLBr_00135|M.leprae_Br4923 GAIGGVLARHMVSAYGVRHLVLASRRGDRA---------EGAVELAAELV MMAR_3798|M.marinum_M GMLGAVFAEHMIARYGARHLLLVSRSGPDA---------PGADDLYQRLT Mflv_0405|M.gilvum_PYR-GCK GAIG-LHTAGYLAQLGAGDIVLTSRRAPDA---------AAQQAIADIAD MAB_0939|M.abscessus_ATCC_1997 GAIG-LHTAAYLAQLGAGDIVLTSRRAPDT---------DAQRVIGEITE MSMEG_0408|M.smegmatis_MC2_155 GAIG-LHTAAYLAQLGAGDIVLTSRRDPDE---------SAQRAIDEITE Mvan_1003|M.vanbaalenii_PYR-1 GALG-LHAAAYLAQLGAGDIVLTGRRMPDA---------ATERAISEIAE TH_2454|M.thermoresistible__bu GALG-LRLAHRLADLGARRLVLVSRSGMPARDSWGRAGDSDTVAAITALE * * :: *. ::*..* Mb2074c|M.bovis_AF2122/97 AAGAQVQVVACDAADRAALAKVIADIPVQHP-LSGVIHTAGALDDAVVMS Rv2048c|M.tuberculosis_H37Rv AAGAQVQVVACDAADRAALAKVIADIPVQHP-LSGVIHTAGALDDAVVMS MUL_2266|M.ulcerans_Agy99 AFGAQVQVVACDAADRAALAKLIADIPMQHP-LSAVIHTAGALDDAVVTS MAV_2450|M.avium_104 AAGAHAEVVACDAADREALAKVIADIPMQHP-LTGVIHAAGVLDDAVVTS MLBr_00135|M.leprae_Br4923 GAGAKIQVVACDVADNDAVRGLFAQLSREFPPVRGVIHAAGVLDDGAITS MMAR_3798|M.marinum_M QLGAQITITACDASDPTALAAVLANIPTEHP-LRAVIHTAAVIDDAVVTE Mflv_0405|M.gilvum_PYR-GCK RTKARLHVFTADVGVEADVAALLERIRAELPPLAGVAHLAGVLDDALLSQ MAB_0939|M.abscessus_ATCC_1997 RSKTRIHVFTADVGAESEVAGLLERIRAELPPLAGVAHLAGVLDDALLGQ MSMEG_0408|M.smegmatis_MC2_155 RHKCRIHTYAADVGDEAQVADLLARIRAELPPLAGIAHLAGVLDDALLSA Mvan_1003|M.vanbaalenii_PYR-1 RYHCRIHTFAADVGDESAVRDLLERIRTELPPLAGVAHLAGVLDDALLPQ TH_2454|M.thermoresistible__bu ERGVSVRVAALDIG-APGAAARLREVLADLPDVRGVIHAAGVEAGALLTN : * . : : : * : .: * *.. .. : Mb2074c|M.bovis_AF2122/97 LTPDRVDVVLRSKVDAAWHLHELTRDLDVSAFVMFSSMAGLVGSSGQANY Rv2048c|M.tuberculosis_H37Rv LTPDRVDVVLRSKVDAAWHLHELTRDLDVSAFVMFSSMAGLVGSSGQANY MUL_2266|M.ulcerans_Agy99 LTPERIETVLRAKVDAAWNLHELTRDMDLSAFVMFSSMAGLVGSSGQGNY MAV_2450|M.avium_104 LTPQRIDTVLRAKVDAAWNLHELTRDLDVGAFVMFSSIAGLAGASGQGNY MLBr_00135|M.leprae_Br4923 LTPDRVDTVLRAKVDAAWNLHEATRDLDLLMFVLCSSIAATVGSPGQGNY MMAR_3798|M.marinum_M LTVEQLDMVLAAKADTAWHLHRLTADINLDVFVVFSAAAAVLGAPGLANY Mflv_0405|M.gilvum_PYR-GCK QSVERFRTALAPKAFGAVHLDRLTRVDDLDFFLVSSSVSSLFGSPGQSNY MAB_0939|M.abscessus_ATCC_1997 QSVERFRTTLAPKAFGAEYLDRLTKGDDLDFFIVSSSVSSLFGSPGQSNY MSMEG_0408|M.smegmatis_MC2_155 QNPERFRTTLAPKAYGASHLDRLTRDDDLDFFIVSSSVSSLFGSPGQANY Mvan_1003|M.vanbaalenii_PYR-1 QSPERFRTTLAPKAFGAWHLHRLTRDTELEFFIVYSSGSSVLGSPGQANY TH_2454|M.thermoresistible__bu TTAEDIEATMRPKVDGVLALHEVFPPGRLDWLVLFSSCGYLGGFPGQGAY . : . .: .*. . *.. : ::: *: . * .* . * Mb2074c|M.bovis_AF2122/97 AAANSFLDALAAHRRAHGLPAISLGWGLWDQASAMTSGLATVDFKRFARD Rv2048c|M.tuberculosis_H37Rv AAANSFLDALAAHRRAHGLPAISLGWGLWDQASAMTGGLATVDFKRFARD MUL_2266|M.ulcerans_Agy99 AAANSFLDGLAVHRQAHGLPAISLGWGLWDQASNMTGGLAAVDFKRFARD MAV_2450|M.avium_104 AAGNSFLDGLAAHRRAHGLPAISLGWGLWDQASAMTGGLGAADLARFGRD MLBr_00135|M.leprae_Br4923 SAANAFLDGLAAYRQAAGLAGTSLAWGLWEQPGGMNAHLSSRDLARISRS MMAR_3798|M.marinum_M AAANAFLDALAHHRHHHGLPATSLAWGYWQTPG-IAAHLDTVSQARFTRN Mflv_0405|M.gilvum_PYR-GCK ATANAFLDGLVAQRRAQGLPATGVNFGPWARGGMASSEAAAANISAQGLI MAB_0939|M.abscessus_ATCC_1997 ATANALLDGLIAQRRAQGLPATGINFGPWGQGGMASSEAATANISAQGLI MSMEG_0408|M.smegmatis_MC2_155 ATANAMLDGLVAKRRAQGLVATGINFGPWGQGGMASSEAATANITAQGLI Mvan_1003|M.vanbaalenii_PYR-1 ATANAVLDGLVAHRKARGLPATGVNWGPWAQGGMATSDAARANLGAQGLI TH_2454|M.thermoresistible__bu ACGNAYLDAFARYRRASGDATTSVAWTAWRGLG--MGSASDFVAAQLDAL : .*: **.: *: * .: : * . . Mb2074c|M.bovis_AF2122/97 GIVAMSSADALQLFDTAMIVDEPFMLPAHIDFAALKVKFDGGTLPPMFVD Rv2048c|M.tuberculosis_H37Rv GIVAMSSADALQLFDTAMIVDEPFMLPAHIDFAALKVKFDGGTLPPMFVD MUL_2266|M.ulcerans_Agy99 GIVAMSSDEALGLLDTAMVLGEPFMLPAHIDFAALRVKFDGGTLPPMFVD MAV_2450|M.avium_104 GIVAMSSQEALELMDTALIVDEPFLLPAHIDLAALRVKFDGGTLPPMFVD MLBr_00135|M.leprae_Br4923 GLAPMNPAQALELFDAALVIDHPFMVTALLDRAALDAQAQAGALPPLFSR MMAR_3798|M.marinum_M HLIPITTEHGLALFDAALACQQPNLVPAPLNTHTLARQARQGVLPAILSS Mflv_0405|M.gilvum_PYR-GCK PLEPSAALTAMAEVVANGTAQATVLKANWQRAAKVLGSSRPPILDLVLPS MAB_0939|M.abscessus_ATCC_1997 PLDPSAALAALAEVVANGTGQATILKANWQRAAKVLGSSRPPILDLVLPS MSMEG_0408|M.smegmatis_MC2_155 PLDPSAALHALAEVIANGSGQATVLKANWQRAAKVLGSARPPILDLVLPS Mvan_1003|M.vanbaalenii_PYR-1 PLEPTAALNALGEIVAHGIASAVVLKANWQRAAKLLGATRPPILDHVLPS TH_2454|M.thermoresistible__bu GMGTVDVDDAMRALDAAIRDGDPNVVVLPLSPAAAAVPMFADVAPADPDA : . .: . : : Mb2074c|M.bovis_AF2122/97 LINAPTRRQVDDSLAAAKSKSALAHRLHGLPEDEQHAVLLDLVRSHIATV Rv2048c|M.tuberculosis_H37Rv LINAPTRRQVDDSLAAAKSKSALLQRLEGLPEDEQHAVLLDLVRSHIATV MUL_2266|M.ulcerans_Agy99 LINAPTRRQVDDSLAAAKSKSALLQRLEGLPEDEQHAILLNLVRSHIATV MAV_2450|M.avium_104 LINAPTRRQVDDSLAAAKSKSALLQRLEGLPEDEQQAVLLDLVRSNIATV MLBr_00135|M.leprae_Br4923 LVRRSRRRQIEDPGDATQSKLALVQRLQGLAANRQLELLVGVVCLQAAAV MMAR_3798|M.marinum_M LITTRRHATIG-------SVETLTAQLATQTPEQQLATLTRLVTTATAAV Mflv_0405|M.gilvum_PYR-GCK AVGEIT------------GDSELLKQLQEIPVPQRAGFVTEFLQKEVQNF MAB_0939|M.abscessus_ATCC_1997 AVGEVT------------GDSELLKQLMEIPVPQRAGFVTEFLQREVQNF MSMEG_0408|M.smegmatis_MC2_155 AAGEAT------------GDSELLKQLMEIPIPQRAGFVTEFLQREVQNF Mvan_1003|M.vanbaalenii_PYR-1 AVAAGP------------GDSALLKQLQDVPEAQRGSFVTEHLQRELQQI TH_2454|M.thermoresistible__bu DAPGGE------------VPDGLSDGFPADGFPDDGDLAEWVHRRVIAAV * : . Mb2074c|M.bovis_AF2122/97 LGSA--SPEAIDPDRAFQDLGFDSLTAVEMRNRLKSATG--LSLSPTLIF Rv2048c|M.tuberculosis_H37Rv LGSA--SPEAIDPDRAFQELGFDSLTAVEMRNRLKSATG--LALSPTLIF MUL_2266|M.ulcerans_Agy99 LGNS--SPDAIDPDRAFQELGFDSLTAVEMRNRLKSATG--LALSPTLIF MAV_2450|M.avium_104 LGSS--SPEAIHPDRAFQELGFDSLTAVEMRNRLKAATG--LALSPTLIF MLBr_00135|M.leprae_Br4923 LGRP--SPEDIDPNTKFQDLGFDSLTAVELRNRLKSATG--LTLPPTVIF MMAR_3798|M.marinum_M LAHP--DPATLEPDLPFKDLGIDSLSALELRNTLTRDTG--ASLPATLVF Mflv_0405|M.gilvum_PYR-GCK LRLA--QPPAATS--RFLDLGTDSLMAIELRNRLHSQFGGAFTINATAVF MAB_0939|M.abscessus_ATCC_1997 LRLA--QPPAATS--RFLDLGTDSLMAIELRNRLHSQFGGKFTINATAVF MSMEG_0408|M.smegmatis_MC2_155 LRLA--SPPAASS--RFLDLGTDSLMAIELRNRLHSQFGGKFTINATAVF Mvan_1003|M.vanbaalenii_PYR-1 LGLA--QPPAATG--RFLELGMDSLMAVELRNRLVGQFGSGFTITATAVF TH_2454|M.thermoresistible__bu AGELGLAETDVDPRLPLVEIGVDSIMTVALRRQLERQTG--LTLPPTLLW : ::* **: :: :*. * * :: .* :: Mb2074c|M.bovis_AF2122/97 DYPNSAALAGYMRRELLGSSPQ-DTSAVAAGEAELQRIVASIPVKRLRQA Rv2048c|M.tuberculosis_H37Rv DYPNSAALAGYMRRELLGSSPQ-DTSAVAAGEAELQRIVASIPVKRLRQA MUL_2266|M.ulcerans_Agy99 DYPNSAALAGYMHRELVGASPQSDTTAEAPGEAELQRVVASIPVKRLRQA MAV_2450|M.avium_104 DYPNSAALAGYMYRELVGTSEQ-PTAAAAPGEAEIQRVVGSIPVKRLRQA MLBr_00135|M.leprae_Br4923 DHPTPTAVAEYVAQQMLKSRPA------ESGDETSQAVEPKVEEVSVHA- MMAR_3798|M.marinum_M DHPTPSAIAQYLNIQLSGSSTT--SRVQDPEEIEMQNLIAKIPAKQLIKS Mflv_0405|M.gilvum_PYR-GCK DYPTIGGLAEYLVAQLPDAETPQAAP-------QSESEPGPDVTE----- MAB_0939|M.abscessus_ATCC_1997 DYPTIGGLAEYLVGQLPDADAESAEAPPAVESAEAESGAGPAAASDAVSE MSMEG_0408|M.smegmatis_MC2_155 DYPTIGGLAEYLVGQLPDAEAPETA------------------------- Mvan_1003|M.vanbaalenii_PYR-1 DYPTIGALAEYLAAQTPESTEEGTEMKTADPDGQPATVGHADVVLQTS-- TH_2454|M.thermoresistible__bu EHPTAGAVSDRIVEMLRARG------------------------------ ::*. .:: : Mb2074c|M.bovis_AF2122/97 GVLDLLLALANETETSGQDPALAPTAEQEIADMDLDDLVNAAFRNDDE- Rv2048c|M.tuberculosis_H37Rv GVLDLLLALANETETSGQDPALAPTAEQEIADMDLDDLVNAAFRNDDE- MUL_2266|M.ulcerans_Agy99 GVLELLLALANETGGNGQAAVTAETSEEDLADMDLDALVNAAFMNDDE- MAV_2450|M.avium_104 GVLELLLALANESTGTAQSATPAVTTEKDIADMDLDDLVNAALLDDDDE MLBr_00135|M.leprae_Br4923 ------------------------------------------------- MMAR_3798|M.marinum_M GVLNILREIADIEHSSSANEKQDNVATMNLDELLIALGDHKGENKNDH- Mflv_0405|M.gilvum_PYR-GCK ------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 LKE---------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 ------------------------------------------------- Mvan_1003|M.vanbaalenii_PYR-1 ------------------------------------------------- TH_2454|M.thermoresistible__bu -------------------------------------------------