For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
aa seq not available
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. thermoresistible (build 8) | TH_4458 | - | - | 100% (1694) | putative Fatty acyl-AMP ligase FadD28_1 and polyketide synthase |
M. thermoresistible (build 8) | TH_2454 | - | e-146 | 39.00% (900) | PUTATIVE beta-ketoacyl synthase |
M. thermoresistible (build 8) | TH_4621 | - | e-137 | 44.28% (664) | PUTATIVE mycocerosic acid synthase |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb2956 | ppsA | 1e-164 | 44.50% (764) | phenolpthiocerol synthesis type-I polyketide synthase PPSA |
M. gilvum PYR-GCK | Mflv_0405 | - | 1e-172 | 39.13% (971) | beta-ketoacyl synthase |
M. tuberculosis H37Rv | Rv0405 | pks6 | 1e-168 | 36.45% (1122) | membrane bound polyketide synthase |
M. leprae Br4923 | MLBr_02357 | - | 1e-159 | 43.43% (753) | polyketide synthase |
M. abscessus ATCC 19977 | MAB_0939 | - | 1e-165 | 44.86% (740) | polyketide synthase |
M. marinum M | MMAR_1180 | - | 0.0 | 39.42% (1451) | Fatty acyl-AMP ligase FadD28_1 and polyketide synthase |
M. avium 104 | MAV_1763 | - | 1e-167 | 48.48% (660) | tylactone synthase modules 4 & 5 |
M. smegmatis MC2 155 | MSMEG_0408 | - | 1e-167 | 44.59% (749) | type I modular polyketide synthase |
M. ulcerans Agy99 | MUL_2019 | ppsA | 1e-161 | 41.26% (875) | phenolpthiocerol synthesis type-I polyketide synthase PpsA |
M. vanbaalenii PYR-1 | Mvan_1003 | - | 1e-173 | 47.60% (750) | beta-ketoacyl synthase |
CLUSTAL 2.0.9 multiple sequence alignment Mflv_0405|M.gilvum_PYR-GCK ---------------MGSAAHQGESAHRFAIVGYAGRFPGARDAESFWEL MAB_0939|M.abscessus_ATCC_1997 ---------------MDSAENPIESTPRFAIIGYAARFPGAADAEEFWDV MSMEG_0408|M.smegmatis_MC2_155 ---------------MVSAEHPIEPTPSFAIIGYAARFPGAASAEEYWAL MAV_1763|M.avium_104 ---------------MSTVEGLRDPASSFAIVGYAARFPGAADADEFWRV Mvan_1003|M.vanbaalenii_PYR-1 MTDLQKRALQAIEVLRARVRELEGAGDGYAIVGYALRFPGAADADEFWDV Mb2956|M.bovis_AF2122/97 -------------------------------------------------- MLBr_02357|M.leprae_Br4923 -------------------------------------------------- MUL_2019|M.ulcerans_Agy99 -------------------------------------------------- Rv0405|M.tuberculosis_H37Rv -------------------------------------------------- TH_4458|M.thermoresistible__bu -------------------------------------------------- MMAR_1180|M.marinum_M -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK LADGRDAISEVPEDRWDVEAFFDPDPSTPGKVVTRRAGFVDDVSGFDAPF MAB_0939|M.abscessus_ATCC_1997 LREGRDAISEVPADRWDAEEFFDPEPGAPGKVVTRRAGFVEDVTGFDAPF MSMEG_0408|M.smegmatis_MC2_155 LRDGREAISDVPKDRWDIEEFFDPDPSTPGKVVTRRAGFVDDVTGFDAPF MAV_1763|M.avium_104 LAEGRDAVSEVPKDRWDADEFFDPDPDAPGKVVTRRAGFVDDVTGFDAPF Mvan_1003|M.vanbaalenii_PYR-1 LRGGRDAISEVPQDRWDADEFFDADPEAAGKMVTRRAGFVEDVAGFDAPF Mb2956|M.bovis_AF2122/97 -------------------------------------------------- MLBr_02357|M.leprae_Br4923 -------------------------------------------------- MUL_2019|M.ulcerans_Agy99 -------------------------------------------------- Rv0405|M.tuberculosis_H37Rv -------------------------------------------------- TH_4458|M.thermoresistible__bu -------------------------------------------------- MMAR_1180|M.marinum_M -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK FGMSTREVRLMDPQHRLLLETAWRAIEHSGTAPSELANTNTGVFVGLATH MAB_0939|M.abscessus_ATCC_1997 FGMSTREVRLMDPQHRLLLETAWRAVEHSGIAPTDLAETNSGVFVGLATH MSMEG_0408|M.smegmatis_MC2_155 FGMSAREVRLMDPQHRILMETAWRAVEHSGIAPTSLANSNTGVFVGLATH MAV_1763|M.avium_104 FGMSAREARLLDPQHRLLLETAWRAVEHSGTAPTDLANTNTGVFIGISTH Mvan_1003|M.vanbaalenii_PYR-1 FGVSAREAMFMDPQHRLLLETAWRAVEHSGTAPSALAGTRTGVFMGLSTH Mb2956|M.bovis_AF2122/97 -------------------------------------------------- MLBr_02357|M.leprae_Br4923 -------------------------------------------------- MUL_2019|M.ulcerans_Agy99 -------------------------------------------------- Rv0405|M.tuberculosis_H37Rv -------------------------------------------------- TH_4458|M.thermoresistible__bu -------------------------------------------------- MMAR_1180|M.marinum_M -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK DYLGMASDELSYPEIEAYMAIGTSNAAAAGRISYRLGLQGPAVAVDTACS MAB_0939|M.abscessus_ATCC_1997 DYLGMASDELTFPEIEAYMAIGTSNAAAAGRISYRLGLQGPSVAVDTACS MSMEG_0408|M.smegmatis_MC2_155 DYLGMASDELTYPEIEAYMAIGTSNAAAAGRISYRLGLQGPAVAVDTACS MAV_1763|M.avium_104 DYLGMASDELTYDQIEAYTAIGTSSAAAAGRISYRLGLQGPAVAVDTACS Mvan_1003|M.vanbaalenii_PYR-1 DYLGMLTDNLTHDAIEAYLGTGTSPAAAIGRISYRLGLQGPAVAVDTACS Mb2956|M.bovis_AF2122/97 -------------------------------------------------- MLBr_02357|M.leprae_Br4923 -------------------------------------------------- MUL_2019|M.ulcerans_Agy99 -------------------------------------------------- Rv0405|M.tuberculosis_H37Rv -------------------------------------------------- TH_4458|M.thermoresistible__bu -------------------------------------------------- MMAR_1180|M.marinum_M -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK SSLVAIHQACQALRLGECDLALAGGANVILTPATMITFSNAHMLAPDGRC MAB_0939|M.abscessus_ATCC_1997 SSLVAIHQACQALQLGECDLALAGGANVLLTPATMITFSHAHMLAPDGKC MSMEG_0408|M.smegmatis_MC2_155 SSLVAIHQACQALRLNECDLALAGGANVLLTPATMITFSNAHMLAPDGRC MAV_1763|M.avium_104 SSLVAIHQACQALRLGECDLALAGGANVLLTPATMITFSQAHMLAPDGRC Mvan_1003|M.vanbaalenii_PYR-1 SSLVAVHQACQALRLAECDVALAGGVNVLLSPATMINFSRARMLAPDGRC Mb2956|M.bovis_AF2122/97 -------------------------------------------------- MLBr_02357|M.leprae_Br4923 -------------------------------------------------- MUL_2019|M.ulcerans_Agy99 -------------------------------------------------- Rv0405|M.tuberculosis_H37Rv -------------------------------------------------- TH_4458|M.thermoresistible__bu -------------------------------------------------- MMAR_1180|M.marinum_M -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK KTFDAAADGYVRGEGCGVIVIKRLEDAVRDGDRIRAVIRGSAINQDGASG MAB_0939|M.abscessus_ATCC_1997 KTFDAAADGYVRGEGSGVIVIKRLEDAIRDGDRIRAVIRGSAINQDGASG MSMEG_0408|M.smegmatis_MC2_155 KTFDAAADGYVRGEGCGVVVVKRLEDAVRDGDRIRAVIRGSAINQDGASG MAV_1763|M.avium_104 KTFDAAADGYVRGEGCGVLVVKRLEDAIRDGDRIRAVIRGSAINQDGASG Mvan_1003|M.vanbaalenii_PYR-1 KTFDATADGYVRGEGCGVVVVKRLADAIRHGDRIRAVIRGSAVNQDGASG Mb2956|M.bovis_AF2122/97 -------------------------------------------------- MLBr_02357|M.leprae_Br4923 -------------------------------------------------- MUL_2019|M.ulcerans_Agy99 -------------------------------------------------- Rv0405|M.tuberculosis_H37Rv -------------------------------------------------- TH_4458|M.thermoresistible__bu -------------------------------------------------- MMAR_1180|M.marinum_M -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK GLTVPNGVAQQRVIGDALSRAGLAPGDVDYLEAHGTGTSLGDPIEAQAAG MAB_0939|M.abscessus_ATCC_1997 GLTVPNGVAQQRVIADALKRAGVAPSEVGYLEAHGTGTSLGDPIEAQAAG MSMEG_0408|M.smegmatis_MC2_155 GLTVPNGVAQQRVIADALKRAGLRPADVGYLEAHGTGTSLGDPIEAQAAG MAV_1763|M.avium_104 GLTVPNGVAQQRVIAEALQRAGIAPGDVDYLEAHGTGTSLGDPIEVQAAG Mvan_1003|M.vanbaalenii_PYR-1 GLTVPNGAAQQRVIADALTNAGLTAADVDYLEAHGTGTPLGDPIEVQAAG Mb2956|M.bovis_AF2122/97 -------------------------------------------------- MLBr_02357|M.leprae_Br4923 -------------------------------------------------- MUL_2019|M.ulcerans_Agy99 -------------------------------------------------- Rv0405|M.tuberculosis_H37Rv -------------------------------------------------- TH_4458|M.thermoresistible__bu -------------------------------------------------- MMAR_1180|M.marinum_M -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK AALGPGREPQRPLLIGSAKTNIGHLEAAAGIAGVIKVVLSLEHETLPKHL MAB_0939|M.abscessus_ATCC_1997 AAYGIGRETNDPLLIGSAKTNIGHLEAAAGIAGVIKVILSLENELLPQHR MSMEG_0408|M.smegmatis_MC2_155 EVLGAGRAPEEPLLIGSAKTNIGHLEAAAGIAGVIKVVMALENETLPKHL MAV_1763|M.avium_104 AVLGAGREASRPLLIGSVKTNIGHLEAAAGIAGVIKVILALEHGMLPQHL Mvan_1003|M.vanbaalenii_PYR-1 AVLGVGREPDRPLLIGSVKTNIGHLEAASGIAGLLKVILSLEHQVLPKHL Mb2956|M.bovis_AF2122/97 -------------------------------------------------- MLBr_02357|M.leprae_Br4923 -------------------------------------------------- MUL_2019|M.ulcerans_Agy99 -------------------------------------------------- Rv0405|M.tuberculosis_H37Rv -------------------------------------------------- TH_4458|M.thermoresistible__bu -------------------------------------------------- MMAR_1180|M.marinum_M -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK NFENPSPHIPWDRLPVEVVKESIPWRRGQRGGRPRIAGVSSFGFAGTNAH MAB_0939|M.abscessus_ATCC_1997 NFQNPSPHIPWDRLPVEVVREARPWGR---NGRPRIAGVSSFGFAGTNAH MSMEG_0408|M.smegmatis_MC2_155 NFETPSPHIPWERLPIEVVRETVPWQR---NGKPRIAGVSSFGFAGTNAH MAV_1763|M.avium_104 HFRDPSPHIPWDRLAVQVVKEATAWQR---NGRPRVAGVSSFGFAGTNAH Mvan_1003|M.vanbaalenii_PYR-1 NFRSPSPHIPWNRLPVRIVDDPVPWTR---SGRSRVAGISSFGFSGTNAH Mb2956|M.bovis_AF2122/97 -------------------------------------------------- MLBr_02357|M.leprae_Br4923 -------------------------------------------------- MUL_2019|M.ulcerans_Agy99 -------------------------------------------------- Rv0405|M.tuberculosis_H37Rv -------------------------------------------------- TH_4458|M.thermoresistible__bu -------------------------------------------------- MMAR_1180|M.marinum_M -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK VILEEAPLAAEPAQES------VDDGRFTLLPLSARTPAALMAVADRYRD MAB_0939|M.abscessus_ATCC_1997 VILEEAPVVSRDAVEPPA---PAGGRKFSILPLSARTPAALAQLADKYRA MSMEG_0408|M.smegmatis_MC2_155 VILEEAPAVGTPATTEP----VEDPRRYSVLPLSARTPEALVRLAGEYRD MAV_1763|M.avium_104 VILEEAPDGTGRAAVPPAAVRPPGQRRFHVLPLSARTPAALVQIAGEYRD Mvan_1003|M.vanbaalenii_PYR-1 VLVEEAPRADRAGAAPQP----AAPGGFGMLPLSARTPDALAATAHRLRT Mb2956|M.bovis_AF2122/97 -------------------------------------------------- MLBr_02357|M.leprae_Br4923 -------------------------------------------------- MUL_2019|M.ulcerans_Agy99 -------------------------------------------------- Rv0405|M.tuberculosis_H37Rv -------------------------------------------------- TH_4458|M.thermoresistible__bu -------------------------------------------------- MMAR_1180|M.marinum_M -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK WLVANPDATLADLCFTAGTARSHLEHRAALVVNTREAALDLLGALADDRP MAB_0939|M.abscessus_ATCC_1997 WLNAHPEAALADLCFTAGVGRAHLEHRAALVVNTREAAVELLSAVADDRP MSMEG_0408|M.smegmatis_MC2_155 WLRAHPQARLADVSHTAGTARAHLEQRAALVVNSRESAIELLGALADDRP MAV_1763|M.avium_104 WLSAHPDTALADLCLTAGAGRAHFEHRAALVVDSTGSAGELLAALADDRP Mvan_1003|M.vanbaalenii_PYR-1 WLAANPDASWPDLCFTAAVGRSHLRHRAALVVDSRSSVEELLGALAEDRP Mb2956|M.bovis_AF2122/97 -------------------------------------------------- MLBr_02357|M.leprae_Br4923 -------------------------------------------------- MUL_2019|M.ulcerans_Agy99 -------------------------------------------------- Rv0405|M.tuberculosis_H37Rv -------------------------------------------------- TH_4458|M.thermoresistible__bu -------------------------------------------------- MMAR_1180|M.marinum_M -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK APGLVRGESHDTPKTAWLFTGQGSQYPGMSRELFDTEPLFAETLRECAAA MAB_0939|M.abscessus_ATCC_1997 APGLGRGESHDTPKTAWLFTGQGSQYPGMARELFETEPVFADTLNRCAAA MSMEG_0408|M.smegmatis_MC2_155 APGLVRGESHEAPKTAWLFTGQGSQYPGMARELFDTEPVFAETVRKCAEA MAV_1763|M.avium_104 APGLLRGVCEDAPKTAWLFTGQGSQYAGMARELFDTEPVFAETLTRCATV Mvan_1003|M.vanbaalenii_PYR-1 GPGLARGECGDPPKTAWLFTGQGSQYPGMGRELFDTEPVYREVMTRCAEA Mb2956|M.bovis_AF2122/97 -------------------------------------------------- MLBr_02357|M.leprae_Br4923 -------------------------------------------------- MUL_2019|M.ulcerans_Agy99 -------------------------------------------------- Rv0405|M.tuberculosis_H37Rv -------------------------------------------------- TH_4458|M.thermoresistible__bu -------------------------------------------------- MMAR_1180|M.marinum_M -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK VDGMLEKPLLDVIFDTDGVLDTDSNETLRHTSYAQPALFAVEMGLARLWQ MAB_0939|M.abscessus_ATCC_1997 VADVLEKPLLDVIFDVD---GPEAEETLRQTSYAQPALFAVEMGLARLWQ MSMEG_0408|M.smegmatis_MC2_155 VADILEKPLLDVIFDAD-ELDGDTESPLRHTTYAQPALFAVELGLARLWQ MAV_1763|M.avium_104 LADVLEKPLLDVIFDTD---DPASEATLRQTSYAQPALFAVEMGLARLWQ Mvan_1003|M.vanbaalenii_PYR-1 VADVLERPLLDVVFDAD------GGEALRHTSYAQPALYAVEMGLARLWQ Mb2956|M.bovis_AF2122/97 -------------------------------------------------- MLBr_02357|M.leprae_Br4923 -------------------------------------------------- MUL_2019|M.ulcerans_Agy99 -------------------------------------------------- Rv0405|M.tuberculosis_H37Rv -------------------------------------------------- TH_4458|M.thermoresistible__bu -------------------------------------------------- MMAR_1180|M.marinum_M -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK SWGFEPDVVLGHSVGQYAAACVAGVLSLRDGARLMAERGRLFGSLPSGGR MAB_0939|M.abscessus_ATCC_1997 SWGFEPDVVLGHSVGQYSAACVAEVFSLEDGARLIAERGRLFSSLPAGGR MSMEG_0408|M.smegmatis_MC2_155 SWGFEPDVVVGHSVGQYSAACVAGVFDVEDGARLIAERGRLFGSLPAGGR MAV_1763|M.avium_104 SWGFEPDVVLGHSVGQYSAACVAGVLRVEDGARLIAERGRLFGSLPAGGR Mvan_1003|M.vanbaalenii_PYR-1 SWGIEPDVVLGHSVGQYAAACVAGVMGLEDGAVLLAERGRLFGSLPEGGR Mb2956|M.bovis_AF2122/97 -------------------------------------------------- MLBr_02357|M.leprae_Br4923 -------------------------------------------------- MUL_2019|M.ulcerans_Agy99 -------------------------------------------------- Rv0405|M.tuberculosis_H37Rv -------------------------------------------------- TH_4458|M.thermoresistible__bu -------------------------------------------------- MMAR_1180|M.marinum_M -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK MAAVFAAAERVEALTDEYPALSVAAYNGANTVLSGPATDLERAVAGLVAD MAB_0939|M.abscessus_ATCC_1997 MAAVFTDAERAERLTDEFPSLSVAAYNGANTVLSGPAQDLEKAIAALVAD MSMEG_0408|M.smegmatis_MC2_155 MAAVFTAPERAERLTDEYPSLSVAAYNGANTVLSGPAKDLESAVATLVAD MAV_1763|M.avium_104 MVAAFAAAARVEGLTDEFPSLSVAAYNGANTVLSGPGQELEQAVARLTAE Mvan_1003|M.vanbaalenii_PYR-1 MAAVFAPADRVESCTVDSPLLSVAAYNGDNTVLSGPAGDLERAVAGFSAA Mb2956|M.bovis_AF2122/97 -------------------------------------------------- MLBr_02357|M.leprae_Br4923 -------------------------------------------------- MUL_2019|M.ulcerans_Agy99 -------------------------------------------------- Rv0405|M.tuberculosis_H37Rv -------------------------------------------------- TH_4458|M.thermoresistible__bu -------------------------------------------------- MMAR_1180|M.marinum_M -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK GVRCDWLETSHAFHSALLDPILDDFESYARGITFTAPQRILIDNRTGAAL MAB_0939|M.abscessus_ATCC_1997 GVRCDFLETSHAFHSALLDPILDEFEAYANQFNYKTPQRILIDNRTGTAL MSMEG_0408|M.smegmatis_MC2_155 GVRCDWLDTSHAFHSALLDPILDDFESFAQKLEYREPQRILIDNRTGSAL MAV_1763|M.avium_104 KVRCDWLDTSHAFHSALLDPILDEFESYANQFDFGPPQRILICNRTGSAL Mvan_1003|M.vanbaalenii_PYR-1 GVRCDWLDTSHAFHSALLDPVLEEFESCADRFEFGTPQRTLVCNRSGEVL Mb2956|M.bovis_AF2122/97 -------------------------------------------------- MLBr_02357|M.leprae_Br4923 -------------------------------------------------- MUL_2019|M.ulcerans_Agy99 -------------------------------------------------- Rv0405|M.tuberculosis_H37Rv -------------------------------------------------- TH_4458|M.thermoresistible__bu -------------------------------------------------- MMAR_1180|M.marinum_M -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK GRSVTLDAAYWRRHARQPVEFAKSVHTLADMNCKLLVEIGPRPVLTAAAL MAB_0939|M.abscessus_ATCC_1997 GRSVKLDGAYWRRHARQPVEFAKSVRTLADMNCKVLLEIGPQPVLTAAAL MSMEG_0408|M.smegmatis_MC2_155 GRSTRLDGAYWRRHARQPVEFAKSVRTLADMNCRVLLEIGPRPVLTATAL MAV_1763|M.avium_104 GRSVKLDGAYWRRHARQPVEFAKSVHTLADLGCKVLLEIGPQPVLTAAAL Mvan_1003|M.vanbaalenii_PYR-1 SRHARLDGQYWRRHARQPVRFAESVRTLADLGCRLLMEIGPQPVLTAAAM Mb2956|M.bovis_AF2122/97 -------------------------------------------------- MLBr_02357|M.leprae_Br4923 -------------------------------------------------- MUL_2019|M.ulcerans_Agy99 -------------------------------------------------- Rv0405|M.tuberculosis_H37Rv -------------------------------------------------- TH_4458|M.thermoresistible__bu --------------------------------LLSLLRQRSERYGDKIAF MMAR_1180|M.marinum_M ---------------------------MLDHSISAVLRERASLRPSETAF Mflv_0405|M.gilvum_PYR-GCK SAWPDPATSPRVIASLRRTTADQRQITEAVADAYVLGHLPRFAAFRRDGA MAB_0939|M.abscessus_ATCC_1997 RAWPDPATAPRAIASLRRNTADHRQITEAAADAYVLGHLPDFGAFQHAPA MSMEG_0408|M.smegmatis_MC2_155 AAWPDPATTPQVLASLRPTTADHRQITEAVAAAYAAGHLPDFRAFRQPDA MAV_1763|M.avium_104 RAWPDPATAPRAIASLRRNTADHRQITEALAEAYIVGHLPDFGAAVG-PA Mvan_1003|M.vanbaalenii_PYR-1 RTWPGTVTAPRVAASMRRKGSDRRQITEALAQAYVAGHRPETAARQHGRG Mb2956|M.bovis_AF2122/97 -------------------------------------------------- MLBr_02357|M.leprae_Br4923 -------------------------------------------------- MUL_2019|M.ulcerans_Agy99 -------------------------------------------------- Rv0405|M.tuberculosis_H37Rv -------------------------------------------------- TH_4458|M.thermoresistible__bu DYCTGEQEHS----RLTYQELDIRARAIAAHLQDQGVAGERVLVLCPSGL MMAR_1180|M.marinum_M TFIDYERDWAGIAETLTWSQLHRRTCNVARELKACGATGDRAVVLAPQGL Mflv_0405|M.gilvum_PYR-GCK RVLDLPTYPFEHRQYWFSDSRE---PVAAAPQR---GARTETVRLLEDGR MAB_0939|M.abscessus_ATCC_1997 RKLDLPTYPFERRQYWFSDKRDGDNRDAGNRQQNNGGPRTEAVRLLEDGK MSMEG_0408|M.smegmatis_MC2_155 RKLDLPTYPFEHRQFWFSDNRAIDRDTQTASAGSVTPHRTQAVRLLEDGQ MAV_1763|M.avium_104 RKLDLPTYPFQHRQYWFSEQRVPPGSQQT-------STQTTAVRLLEDGR Mvan_1003|M.vanbaalenii_PYR-1 RLLDLPTYPFQHRAYWFPQGQARTAPTDP--------VHTETVRFLDEER Mb2956|M.bovis_AF2122/97 -------------------------------------------------- MLBr_02357|M.leprae_Br4923 -------------------------------------------------- MUL_2019|M.ulcerans_Agy99 -------------------------------------------------- Rv0405|M.tuberculosis_H37Rv -------------------------------------------------- TH_4458|M.thermoresistible__bu DFITAMFGCFYVGAVAVPVHPPVHNRLLSRVASIVADVRATSVLTTAATR MMAR_1180|M.marinum_M DYIVAFLGALQAGQIAVPLSAPLGGASDERVGSVLRDALPSAILTTSPIA Mflv_0405|M.gilvum_PYR-GCK IEELAALLGGTVDDPFTFDVLNRLAAQHNQQRSTESIADDRYQIRWETAA MAB_0939|M.abscessus_ATCC_1997 IEELANLLGGVDGDQQTLNVLTKLAAQHNLQRTTQTIADDRYQFRWEKSP MSMEG_0408|M.smegmatis_MC2_155 IEELAALIDGETVDEQTLRVLNKLAARHNQQRSTHVDPDARYEIRWDAIA MAV_1763|M.avium_104 IAELAELLDGASADQHTLDVLTKLAAQHNQQRKSRSIAEDRYEIRWEKST Mvan_1003|M.vanbaalenii_PYR-1 IDELAALLDGPTGSAQTVDVLSKLAARHRQQRGAQSIADARYQIRWEKSE Mb2956|M.bovis_AF2122/97 -------------------------------------------------- MLBr_02357|M.leprae_Br4923 -------------------------------------------------- MUL_2019|M.ulcerans_Agy99 -------------------------------------------------- Rv0405|M.tuberculosis_H37Rv -------------------------------------------------- TH_4458|M.thermoresistible__bu ADLKEILDGLHDGDPLRWLAVDTIEADDETSWTPTTVDTDSVAFVQYTSG MMAR_1180|M.marinum_M GDVAECITLTPGKRAPSVIEIDLLDPDSGQGPAAESDSGSDIAYLQYTSG Mflv_0405|M.gilvum_PYR-GCK EPPVGADAADGITWLLVGDDTDATRPLVDVLAARGHRYRILGLPKSGAEE MAB_0939|M.abscessus_ATCC_1997 TPLSGSQAAGGVTWLLVADAAGAAQPLLDVLTARGQQHRVLALPVSDADE MSMEG_0408|M.smegmatis_MC2_155 SAAASTGAAA--DWILVGDDTAAVLEFADALTAGGHRHQIVALPGSDADE MAV_1763|M.avium_104 VPG----PEAEATWLVVGDDDDAVAPLVDALTARGHQHRILVLPASDADE Mvan_1003|M.vanbaalenii_PYR-1 APGAARPTTEATTWLLVTHDSRAAQPIAEVLERRGHPYHIVGLPGSDADA Mb2956|M.bovis_AF2122/97 -------------------------------------------------- MLBr_02357|M.leprae_Br4923 -------------------------------------------------- MUL_2019|M.ulcerans_Agy99 -------------------------------------------------- Rv0405|M.tuberculosis_H37Rv -------------------------------------------------- TH_4458|M.thermoresistible__bu STSTPKGVVLTHHNLLANLES-ISRDAGQG-----DEARVVSWLPLHHDM MMAR_1180|M.marinum_M STRTPAGVVVSHRNLLANVEQGMSAYFGDHGRAAPPDTTVVSWLPFFHDM Mflv_0405|M.gilvum_PYR-GCK HELADTLRDAAADATDLRIVHVAALDAAESDTSMKSLLRMQHRVLGGTRR MAB_0939|M.abscessus_ATCC_1997 AELVEALRSAADEDSALRIVHVAALAGQGS-SSAQSLLRIQHQVLGGTRR MSMEG_0408|M.smegmatis_MC2_155 AQLVDTLRAASAG--ELYVVHIAAGDGAAA--PMRDLLRVQHRTLGGLRR MAV_1763|M.avium_104 ERLEIVLRAAAAEEAPLRIALVAALDSGTA-PSMRSLLRMQHRVLAGTRR Mvan_1003|M.vanbaalenii_PYR-1 APAEEALRATVSQ-PRPHILYLAALEEPGG-SAAETLGWMQHRVLAAARR Mb2956|M.bovis_AF2122/97 -------------------------------------------------- MLBr_02357|M.leprae_Br4923 -------------------------------------------------- MUL_2019|M.ulcerans_Agy99 -------------------------------------------------- Rv0405|M.tuberculosis_H37Rv -------------------------------------------------- TH_4458|M.thermoresistible__bu GLIGGIFGVVHFGGTAYLMPPSSFIQRPMSWLEAISWHGANISVGPNFGY MMAR_1180|M.marinum_M GLMFGIIMPLLEGFHSVLTSPISFLQRPARWMQLLASNCQVFSAAPNIAF Mflv_0405|M.gilvum_PYR-GCK LFGAAVAAQLRSPMWLVTRGAQHVTDTDVVAPDQTCLWGFGRAASLEHPQ MAB_0939|M.abscessus_ATCC_1997 LFRAAAAAELRAPIWIVTRGAQHVIEGDTVAPEQSALWGFGRAAALELPQ MSMEG_0408|M.smegmatis_MC2_155 LFRAANDAELRSPIWLVTRDGQRVTDTDTVVPEQSCLWGFGRAAALELPH MAV_1763|M.avium_104 LFRAAAAAELRQPIWLVTRGAQRVTDADTVFPDQSCLWGFGRAASLEYPQ Mvan_1003|M.vanbaalenii_PYR-1 LFQLAATAGARAPIWLITAGAQRITGDETVEPAQTSLWGFGRAAALEQPE Mb2956|M.bovis_AF2122/97 -------------------------------------------------- MLBr_02357|M.leprae_Br4923 -------------------------------------------------- MUL_2019|M.ulcerans_Agy99 -------------------------------------------------- Rv0405|M.tuberculosis_H37Rv -------------------------------------------------- TH_4458|M.thermoresistible__bu QLCVERSTPEERATLDLSTWVRAYCGAEPVRAATMRRFTEAFAPAGFRAD MMAR_1180|M.marinum_M ELAARKTSDDDLAGLDLGGVRNILSGAERVQPATLARFAQRFARFHLHPR Mflv_0405|M.gilvum_PYR-GCK IWGGLADLGGGTSDEWSRLLNRIAATHDPAVMEDQVAVRGSTSYVPRLVH MAB_0939|M.abscessus_ATCC_1997 VWGGLADLSDAGTDEWAQFIGRVSVSGEASTREDQLALRGQAVHVPRLVR MSMEG_0408|M.smegmatis_MC2_155 IWGGLADLSGADT-EWPRLIARITSPRDG---EDQIALRGDAVYAPRLVR MAV_1763|M.avium_104 LWGGLADLAQGSAEEWSRLVRVASAPRDPAVGEDQIALRGSDIYVPRLTR Mvan_1003|M.vanbaalenii_PYR-1 LWGGLADVTTGDAEEWSALIDHIVAAPTS---EDQIAVRGREIHVARLTR Mb2956|M.bovis_AF2122/97 -------------------------------------------------- MLBr_02357|M.leprae_Br4923 -------------------------------------------------- MUL_2019|M.ulcerans_Agy99 -------------------------------------------------- Rv0405|M.tuberculosis_H37Rv -------------------------------------------------- TH_4458|M.thermoresistible__bu AFHPVYGLAEATLFVSGRPENVLPTVRSLDNAALREHRVVPAAADDANAA MMAR_1180|M.marinum_M ALRPSYGLAEATVFVATREWGQPPVTVYFDSDELTAGHAKRCATGTG--T Mflv_0405|M.gilvum_PYR-GCK RDTLPSGKPLHLRADATYLVTGGLGSLGLEIAGYLAANGAGHLVLTSRRT MAB_0939|M.abscessus_ATCC_1997 REELPSGKPLEVRSDATYLVTGGLGSIGLEIAGYLAGRGAKHLVLTSRRE MSMEG_0408|M.smegmatis_MC2_155 RTGEPSDTPLPVREDRTYLVTGGLGAIGLEVAGYLASHGAGHVVLTSRRE MAV_1763|M.avium_104 RSGQPAAAALTLRADATYLVTGGLGSIGLEIAGHLAAQGARHLVLTGRRA Mvan_1003|M.vanbaalenii_PYR-1 CAEKANAAALELRREATYLVTGGLGALGLEVAEFLASHGAGHLVLTGRRS Mb2956|M.bovis_AF2122/97 -------------------------------------------------- MLBr_02357|M.leprae_Br4923 -------------------------------------------------- MUL_2019|M.ulcerans_Agy99 -------------------------------------------------- Rv0405|M.tuberculosis_H37Rv -------------------------------------------------- TH_4458|M.thermoresistible__bu AVVGCGPAAYGEEIVIVDPATRREFPPDVVGEIWVAGENVAQGYLGKPSE MMAR_1180|M.marinum_M ALISYG-AAQSPTVRIVDPQTATECPAGVVGEIWVHGDNVAAGYWHRPQE Mflv_0405|M.gilvum_PYR-GCK PDEAAASRIEALRERHGCEVRVVTADVADAHAVARLLATVQAEMPPLAGI MAB_0939|M.abscessus_ATCC_1997 PGEAARQRIDALAA-QGCEVRAVTADVADGHDVARLLAGIQAELPPLAGI MSMEG_0408|M.smegmatis_MC2_155 PGDDARRRLDGLREQYACDVRVITADVADAHDVARLMTTVAAELPPLAGI MAV_1763|M.avium_104 PGEAAQRRIDALSQQHGCEVRVIAADVADAHHVARLLGAVRAELPPVAGI Mvan_1003|M.vanbaalenii_PYR-1 ASDTVRQRIDAMRERFDCQVLVATADVADRDDVARLFSTMRSELPPLAGI Mb2956|M.bovis_AF2122/97 -------------------------------------------------- MLBr_02357|M.leprae_Br4923 -------------------------------------------------- MUL_2019|M.ulcerans_Agy99 -------------------------------------------------- Rv0405|M.tuberculosis_H37Rv -------------------------------------------------- TH_4458|M.thermoresistible__bu SAETFAAHLADSGR----GPFLRTGDYGFLLDGELFVTGRLKDLIIIRGR MMAR_1180|M.marinum_M TERTFGATLVGPSPGTPPGPWLRTGDLGAFSEGELFIIGRIKDLLIIYGR Mflv_0405|M.gilvum_PYR-GCK VHAAGEIGTTPLADLDDAEVDRVFAGKVWGAWHLSEATSDLQ--LDFFIS MAB_0939|M.abscessus_ATCC_1997 VHAAGEIGTTPLSDLEDAEVDRVFAGKVWGAWHLSEAAAGLK--LDFFIN MSMEG_0408|M.smegmatis_MC2_155 VHAAGEIGTTPLSGLDDAEVDRVFAGKVWGAWHLSEALTDLRTDLDFFVS MAV_1763|M.avium_104 VHAAGEIGTTPLSDLEDAEIDRVFAGKVWGAWHLSEAAADLR--LDFFVS Mvan_1003|M.vanbaalenii_PYR-1 VHAAGEIGTSPLRTLDDAEMDRVFAGKVWGAVYLCEEVADMG--LDFFLA Mb2956|M.bovis_AF2122/97 -------------------------------------------------- MLBr_02357|M.leprae_Br4923 -------------------------------------------------- MUL_2019|M.ulcerans_Agy99 -------------------------------------------------- Rv0405|M.tuberculosis_H37Rv -------------------------------------------------- TH_4458|M.thermoresistible__bu NYHPNDIEATVQEVHPALMSGRGAAFAVS--------------------- MMAR_1180|M.marinum_M NHSPDDIEATIQEVT----RGRCVAIAV---------------------- Mflv_0405|M.gilvum_PYR-GCK TSSIASVWGGFGQAAYGAANAFLDGLAWRLREQGVAGVSVNFGPWSAGMA MAB_0939|M.abscessus_ATCC_1997 TSSIAAVWGGYGQTAYSAANAFLDGLAWRLREQGIAGTSVNFGPWSAGMA MSMEG_0408|M.smegmatis_MC2_155 TSSIASVWGGFGQTAYGAANAFLDGLAWRLRERGVTAVSVNFGPWAAGMA MAV_1763|M.avium_104 TSSIASVWGGLGQTAYGAANAFLDGLAWRLREQGVNGISVNFGPWAAGMA Mvan_1003|M.vanbaalenii_PYR-1 TSSIASVWGSHGQTAYGAANAFLDGLADSLRARGIPGISVNFGPWAAGMA Mb2956|M.bovis_AF2122/97 -------------------------------------------------- MLBr_02357|M.leprae_Br4923 -------------------------------------------------- MUL_2019|M.ulcerans_Agy99 -------------------------------------------------- Rv0405|M.tuberculosis_H37Rv -------------------------------------------------- TH_4458|M.thermoresistible__bu ---------------------------PDPSGTEQLVIVQEVDRGRLGEV MMAR_1180|M.marinum_M ---------------------------PDDGGVEKLVVIVEFKTRETSHE Mflv_0405|M.gilvum_PYR-GCK DAQSRARLEQRGIKTLSPADALAGLSDAVISAAP---HPVVARVDWSRFL MAB_0939|M.abscessus_ATCC_1997 DAESRARLEQRGIKTLSPTDALAGLADVVAASGSNAVQGVIARIDWARFL MSMEG_0408|M.smegmatis_MC2_155 DAESRARLEQRGVRTLSPAEALAGMADVVAGPVQ----GVVAKIDWSRFL MAV_1763|M.avium_104 DENARARLAQRGIKTLSPADALAGLADVMATAAA---QGVVARIDWTRFL Mvan_1003|M.vanbaalenii_PYR-1 DAKAREQLSRRGVKTLAPADALAGMADVIAASTA---HAVVARIDWATFL Mb2956|M.bovis_AF2122/97 -------------------------------------------------- MLBr_02357|M.leprae_Br4923 -------------------------------------------------- MUL_2019|M.ulcerans_Agy99 -------------------------------------------------- Rv0405|M.tuberculosis_H37Rv -------------------------------------------------- TH_4458|M.thermoresistible__bu DTDELIAAIR----TAVTSQHDIGVHTVVLVDPLRIPTTSSGKIRRRTCR MMAR_1180|M.marinum_M ATMHRMGVVRRDVIAAISKTHGLNVADLVLVPPGSIPLTTSGKVRRRECL Mflv_0405|M.gilvum_PYR-GCK PLYQQAGRRGFLAELERELPAAPAQQGPAVTASGRTPLVERLTTAPLQQR MAB_0939|M.abscessus_ATCC_1997 PLYQQAGKRGFLAELDREVPSHLA--GVAGAQSGSTQLVERLANAPVQQR MSMEG_0408|M.smegmatis_MC2_155 PLYQQAGRRAFLSELESELPAAATGAAAPATVPGKPPLVEQLTKAPVQQR MAV_1763|M.avium_104 PLYQQAGQRSLLAELAREIPDFAP----APTPSGKTGLVERLAGAPVQQR Mvan_1003|M.vanbaalenii_PYR-1 PVYQLQRRRAFLSQLEREVPDVPD--ASAPAPSGTTRFVEELTLAPVEQR Mb2956|M.bovis_AF2122/97 -------------------------------------------MTGSISG MLBr_02357|M.leprae_Br4923 -------------------------------------------MTASIGS MUL_2019|M.ulcerans_Agy99 -------------------------------------------MTPSIGG Rv0405|M.tuberculosis_H37Rv -------------------------------------------MTDGSVT TH_4458|M.thermoresistible__bu QRFLDGELDAFAEWRLATPRPAQPVPAADEQADEQAGAGPGAGPGADEIR MMAR_1180|M.marinum_M QRYLHDEFTRLDGQLREPGPRVADAAAADADAGADSGLVQRLRLLRHQQH Mflv_0405|M.gilvum_PYR-GCK KRLLTDYLRDAVAEVTRVDAAEIREDAGFFDLGMDSLMAVELRRRIETGV MAB_0939|M.abscessus_ATCC_1997 KKLLTDYLRDAVAEVTRVDVSEIREDAGFFDLGMDSLMAVELRRRMEQGV MSMEG_0408|M.smegmatis_MC2_155 KSLITNYLRNAVAEVTRVDADEIRDEAGFFDLGMDSLMAVELRRRIEQGV MAV_1763|M.avium_104 RKLMTEFLRNAVAEVTRVDAAEIREDAGFFDLGMDSLMAIELRRHIEQGV Mvan_1003|M.vanbaalenii_PYR-1 RKLVLEYLRAAVAEVTRVDAAEIRDEAGFFDLGMDSLMAIELRRRLEQGL Mb2956|M.bovis_AF2122/97 EADLRHWLIDYLVTNIGCTPDEVDPDLSLADLGVSSRDAVVLSGELSELL MLBr_02357|M.leprae_Br4923 EADLCHWLVNYLVTNIGCTPDEVDLNLSLTDLGMSSRDAVVLSGELTDLL MUL_2019|M.ulcerans_Agy99 EADLRHWLVDYLVTNIGCPPDEVDPNLSLADLGVSSRDAVVLSGELTELL Rv0405|M.tuberculosis_H37Rv ADKLQKWFREYLSTHIECHPNEVSLDVPIRDLGLKSIDVLAIPGDLGDRF TH_4458|M.thermoresistible__bu AWFVAQLAGELG-----LSPDDIDTGQPFAYYGLDSVRAIQLMTALEAWS MMAR_1180|M.marinum_M DLLVGVVCAQAATVLDYPSPNDIDPEWAFQDLGFDSVKATELLDRLQTVT : :: : *..* . : : Mflv_0405|M.gilvum_PYR-GCK GKEIPVTLVMDHPRLSDAADYLLGDVLGLTEAAT-APKAAT--------V MAB_0939|M.abscessus_ATCC_1997 GKEIPVTLVMDHPRISDVADYLLGDVLGLAEQAKPAAQLAS--------A MSMEG_0408|M.smegmatis_MC2_155 GKDIPVTLVMDHPRLSDAADYLLVEVLGLGEQTN--VRQAS--------T MAV_1763|M.avium_104 GKQIPATLAMDYPRLSDVAEYLLGDVLDLRGQPDAKPAPPAG-----TPA Mvan_1003|M.vanbaalenii_PYR-1 GKELPVTLAMDHPHLSDAAEYVLGDVLGLSEHTVAQPDTPS--------- Mb2956|M.bovis_AF2122/97 GRTVSPIDFWEHPTINALAAYLAAPEPSPDSDAAVKRGARN--------- MLBr_02357|M.leprae_Br4923 GKTVSPIDFWEHPTINALAAYLIAPAPDPESESAPRRSVQG--------- MUL_2019|M.ulcerans_Agy99 GRTVSPIDFWEHPTINDLAAYLTAPEPSTGAEAAVSRTVRG--------- Rv0405|M.tuberculosis_H37Rv GFCIPDLAVWDNPSANDLIDSLLNQRSADSLRESHGHADRN-------TQ TH_4458|M.thermoresistible__bu GIKVAPTLAYDHPTIDLAAEHLAGLTHTATSTAADAGVSTGAGRRPEHGP MMAR_1180|M.marinum_M ELTLPPTLAFDYPTPAALATHLGQLLSGSVAVAAPVQPRVST-------- :. : * : Mflv_0405|M.gilvum_PYR-GCK VSTAADEPIAIVAVSCRFPG-APNPEAFWDLLSGGVDAIREVPEDR-FDI MAB_0939|M.abscessus_ATCC_1997 VTGRTDEPIAIVAVSCRFPG-APDPEAFWDVLSGGVDAIREVPEDR-FDI MSMEG_0408|M.smegmatis_MC2_155 VTARTDDPIAVVAVSCRFPG-APDPESFWELLAGGVDAIREVPEDR-WDI MAV_1763|M.avium_104 PAGRTDEPIAIVAMACRFPG-AADPEAFWELLSGGVDAIREVPEDR-FDI Mvan_1003|M.vanbaalenii_PYR-1 -TVRTDDPIAIVGMACRFPG-ADDTDAFWSVLAEGADLIREIPDDR-FDI Mb2956|M.bovis_AF2122/97 ---SLDEPIAVVGMGCRFPGGISCPEALWDFLCERRSSISQVPPQR-WQP MLBr_02357|M.leprae_Br4923 ---ALEEPIAVIGMGCRFPGGISGPEALWQFLCDRRSSIGQVPNER-WEL MUL_2019|M.ulcerans_Agy99 ---SLEEPIAVVGMGCRFPGGISGPEALWQFLCDRKSSIGRVPDER-WAQ Rv0405|M.tuberculosis_H37Rv GRGSINEPVAVIGVGCRFPGDIDGPERLWDFLTEKKCAITAYPDRG-FTN TH_4458|M.thermoresistible__bu APDRADEPIAIIGIGCRFPG-ADGPAAYWRLLREGRDAITATPPER---- MMAR_1180|M.marinum_M -----DEPVAVVGMACRFPGGVDSAAALWDLVAGGTEAVGEFPADRGWNL ::*:*::.:.***** . * .: : * Mflv_0405|M.gilvum_PYR-GCK DEFYDPDPDAAGKTYTRYGGFLDHIDEFDPEFFGLSPREAVWIEPQQRLM MAB_0939|M.abscessus_ATCC_1997 DEFYDPDPEVAGKTYTRFGGFLDGIDGFDPEFFGISPREAVWIEPQQRLM MSMEG_0408|M.smegmatis_MC2_155 DEFYDPDPDTPGKTYTRFGGFLDGIDGFDPEFFGISPREAVWIEPQQRLM MAV_1763|M.avium_104 DEFYDPDPETPGKMYSRFGGYLDQIDEFDPEFFGISPREAVWIDPQQRLV Mvan_1003|M.vanbaalenii_PYR-1 NEFYDPDPEAAGKIYSRYGGFLDGVDGFDPEFFGISPREAVWIDPQQRLV Mb2956|M.bovis_AF2122/97 FEGGPPEVAAALARTTRWGSFLPDIDAFDAEFFEISPSEADKMDPQQRLL MLBr_02357|M.leprae_Br4923 FDDGSPEVKALLARTTRWGSFLEDIDAFDSEFFEISPSEADKMDPQQRLL MUL_2019|M.ulcerans_Agy99 FDDGSPAVKALLARTTRWGSYLTDIDAFDADFFEISASEADKMDPQQRLL Rv0405|M.tuberculosis_H37Rv AG-----------TFAESGGFLKDVAGFDNRFFDIPPDEALRMDPQQRLL TH_4458|M.thermoresistible__bu -----WDTDSVGDG-TRWGGFLERIDGFDAGFFGISPREAVRIDPQQRLL MMAR_1180|M.marinum_M AELFDPDPDAVGKTYARAGSFVADVAGFDAEFFGISAREAQTMDPQQRLL :. *.:: : ** ** :.. ** ::*****: Mflv_0405|M.gilvum_PYR-GCK LETVWEGLERAGYAPSALRGSRTGVFVGVAANEYAHLLSAESIDKIEPHF MAB_0939|M.abscessus_ATCC_1997 LETVWEGLERAGYSPAALRGSRTGIFAGVGANEYAHLLSSESIDKIEPYF MSMEG_0408|M.smegmatis_MC2_155 LETVWEGLERAGYAPSDLRGSRTGVFTGVAANEYAHLLSAESIDKIEPHF MAV_1763|M.avium_104 LETVWEGLERAGYSPAALRGSRSGIFVGVGANEYSHLLSAESVDKIEPHF Mvan_1003|M.vanbaalenii_PYR-1 LETAWEGLERAGYSAAALRGSRSGVYVGVGANEYSHLLSGGSLDGIEAQF Mb2956|M.bovis_AF2122/97 LEVAWEALEHAGIPPGTLRRSATGVFAGACLSEYGAMAS-ADLSQVDGWS MLBr_02357|M.leprae_Br4923 LEVAWEALEHAGISSNSLRRSQTGVFAGSCLSEYGAIAS-TDLSQVDGWS MUL_2019|M.ulcerans_Agy99 LEVAWEALEHAGIPPSSLRRSQTGVFAGSCLSEYGAIAS-TDLTQVDGWS Rv0405|M.tuberculosis_H37Rv LEVSWEALEHAGIIPESLRLSRTGVFVGVSSTDYVRLVSASAQQKSTIWD TH_4458|M.thermoresistible__bu LEVAWEALEDAGLVPDRLAGSRTGVFTGVSTYDYLHLQL-SHPELIDAYS MMAR_1180|M.marinum_M LEVCWEALETAQIDPAALLRSKTGVFVGAWSQQYG-----GGSEGAEGYG **. **.** * . * * :*::.* :* Mflv_0405|M.gilvum_PYR-GCK ITGNALNAISGRVAFALGLEGPAVAVDTACSSSLVAVHQATQALRSGDCD MAB_0939|M.abscessus_ATCC_1997 ITGNALNAISGRVAFALGFEGPAVAVDTACSSALVAVHQAVQALHSGDCD MSMEG_0408|M.smegmatis_MC2_155 ITGNALNAISGRVAFALGFEGPAVAVDTACSSALVAVHQACQALQSGDCD MAV_1763|M.avium_104 ITGNALNAISGRVAFALGLEGPAVAVDTACSSSLVAVHQACQALHSGDCD Mvan_1003|M.vanbaalenii_PYR-1 ITGNALNVIAGRVSFTLGLEGPAVAVDTACSSSLVAVHQACQGLQSGDCD Mb2956|M.bovis_AF2122/97 NSGGAMSIIANRLSYFLDLRGPSVAVDTACSSSLVAIHLACQSLRTQDCH MLBr_02357|M.leprae_Br4923 NTGGAMSIIANRLSYFLDLRGPSVAVDTACSSSLVAIHLACQSLRTADAN MUL_2019|M.ulcerans_Agy99 NTGGAMSIIANRLSYFLDLRGPSVAVDTACSSSLVAIHLACQSLRMQDSN Rv0405|M.tuberculosis_H37Rv NTGGSSSIIANRISYFLDIQGPSIVIDTACSSSLVAVHLACRSLSTWDCD TH_4458|M.thermoresistible__bu GTGTASSIAANRLSYVFDFRGPSLTLDSACSSSLVAVHQACRSLRDGECD MMAR_1180|M.marinum_M LTGLSTSVASGRVAYALGLQGPAITIDTACSSSLVAAHLACQSLHTGEST :* : . :.*::: :.:.**::.:*:****:*** * * :.* :. Mflv_0405|M.gilvum_PYR-GCK MALAGGVNVLLSPVTVVAASRARMLSPVGRCKTFDASADGYVRSEGCGIL MAB_0939|M.abscessus_ATCC_1997 LALAGGVNVLLSPVTVIAASRARMLSPVGRCKTFDASADGYVRSEGCGIL MSMEG_0408|M.smegmatis_MC2_155 LALAGGVNVLLSPVTVVAASRARMLSPVGRCKTFDASADGYVRSEGCGVL MAV_1763|M.avium_104 LALAGGVNVLLSPVSNIAASRARMLSPVGRCKTFDATADGYVRSEGCGIL Mvan_1003|M.vanbaalenii_PYR-1 LALAGGVNVLLSPATTIATSRARMLSPDGRCKTFDAAADGYVRGEGCGIL Mb2956|M.bovis_AF2122/97 LAIAAGVNLLLSPAVFRGFDQVGALSPTGQCRAFDATADGFVRGEGAGVV MLBr_02357|M.leprae_Br4923 LAIAAGVNLLLSPAVFRGFDQVGALSPTGCCRAFDAAADGFVRGEGAGVV MUL_2019|M.ulcerans_Agy99 LAIAAGVNLLLSPAVFRGFDQVGALSPTGNCRAFDAAADGFVRGEGAGVV Rv0405|M.tuberculosis_H37Rv IALVGGTNVLISPEPWGGFREAGILSQTGCCHAFDKSADGMVRGEGCGVI TH_4458|M.thermoresistible__bu LALAGGVNIMLSAGIGLNFTRAGVMATDGRCKTFDARADGWVRGEGAGIV MMAR_1180|M.marinum_M LALAGGVTVMTTPAVFTEFARQRGLAADGRCKAFSAAADGTGWGEGAAVL :*:..*..:: :. . :: * *::*. *** .**..:: Mflv_0405|M.gilvum_PYR-GCK VLKRLSDAVRDGDRVCAVIAGSAVNQDGASSGLTVPNGGAQQRLIGTVLA MAB_0939|M.abscessus_ATCC_1997 VLKRLSDAERDGDRVLAVIPGSAVNQDGASSGLTVPNGGAQQRLIGSVLA MSMEG_0408|M.smegmatis_MC2_155 VLKRLSDAVRDGDRVCAVIPASSVNQDGASSGLTVPNGGAQQRLIEATLA MAV_1763|M.avium_104 VLKRMSDAVRDGDRVCAVIPASAVNQDGASSGLTVPNGGAQQRLIATALS Mvan_1003|M.vanbaalenii_PYR-1 VLKRLSDAVRDGDRIQAVIRGSAVNQDGASGGLTVPNGGAQQRVIAAALT Mb2956|M.bovis_AF2122/97 VLKRLTDAQRDGDRVLAVICGSAVTQDGRSNGLMAPNPAAQMAVLRAAYT MLBr_02357|M.leprae_Br4923 VLKRLTDAQRDGDRVLAIIRGSAVNQDGRSNGLMAPNPAAQVAVLRTAYA MUL_2019|M.ulcerans_Agy99 VLKRLTDAQQDGDRVLAVICGSAINQDGRSNGLMAPNPAAQQAVLRAAYT Rv0405|M.tuberculosis_H37Rv VLQRLSDARLEGRRILAILTGSAVNQDGKSNGIMAPNPSAQIGVLENACK TH_4458|M.thermoresistible__bu VLKPLREALADEDPIYAVIRGSAVNQDGRTNGLMAPSRTAQEVVLTDAYR MMAR_1180|M.marinum_M VLERLSDANRNGHPVLAVIAGSAINQDGASNGLTAPSGPAQQRVITQAVA **: : :* : : *:: .*::.*** :.*: .*. ** :: . Mflv_0405|M.gilvum_PYR-GCK RAGITGGEVDYLEAHGTGTPLGDPIEVQAAAAAYAGARDADRPLLMGSVK MAB_0939|M.abscessus_ATCC_1997 RAGLVGGDVDYLEAHGTGTPLGDPIEVQAAAAAYGGSRDADRPLLMGSVK MSMEG_0408|M.smegmatis_MC2_155 RAGLSGADVDYLEAHGTGTPLGDPIEVQAAAAAYGAGRDADRPLLMGSVK MAV_1763|M.avium_104 RAGLSGDDVDYLEAHGTGTALGDPIEVQAAGAVYGATRDTDRPLLIGSVK Mvan_1003|M.vanbaalenii_PYR-1 RAGLSGSDIDYLEAHGTGTSLGDPIEVQAAGAVLGAGRDPDRPLLMGSVK Mb2956|M.bovis_AF2122/97 NAGMQPSEVDYVEAHGTGTLLGDPIEARALGTVLGRGRPEDSPLLIGSVK MLBr_02357|M.leprae_Br4923 NAAMPPTAIDYVETHGTGTLLGDPIEARALGAVLGRGRAEDSPLLIGAVK MUL_2019|M.ulcerans_Agy99 NAGMQPSEVDYVEAHGTGTLLGDPIEARALGSVLGRGRPEESPLLIGAVK Rv0405|M.tuberculosis_H37Rv SARVDPLEIGYVEAHGTGTSLGDRIEAHALGMVFGRKRPGSGPLMIGSIK TH_4458|M.thermoresistible__bu RAGVSPGVVQYVEAQGIGTPVGDAIEVGALGTVLAEDRPPDSPCLIGSVK MMAR_1180|M.marinum_M NAGVGLDEVDAVEAHGTGTTLGDPIEAGALIATYGAAHHPDHPLWLGSIK * : : :*::* ** :** **. * . . : . * :*::* Mflv_0405|M.gilvum_PYR-GCK TNIGHTESASGAAGLIKVVLSLQHETLPQSLHFDTPSPHIPWDSLPVRVV MAB_0939|M.abscessus_ATCC_1997 SNIGHTESASGAAGLIKVVLSLQNGVLPQSLHFDNPSPHIPWESLPVRVV MSMEG_0408|M.smegmatis_MC2_155 TNIGHTESASGAAGLIKVVLSLQHGVLPQSLHFENPSPHIPWDALPVRVI MAV_1763|M.avium_104 TNIGHLEAASGVAGLIKVVLSLQHEMLPQSLHFETPSPHIPWDSLPLRVV Mvan_1003|M.vanbaalenii_PYR-1 TNVGHLESASGVAGLIKVVLSLQHEMLPRHLHFKTPSPHIPWDRLAVRVV Mb2956|M.bovis_AF2122/97 TNLGHTEAAAGIAGFIKTVLAVQHGQIPPNQHFETANPHIPFTDLRMKVV MLBr_02357|M.leprae_Br4923 TNLGHLEAAAGIAGFIKTVLAVQRGQIPPNQRFESPNLHIPFAELRMKVV MUL_2019|M.ulcerans_Agy99 TNLGHTEAAAGIAGFIKAVLAVQHGRIPPNQRFESPNPHIAFADLRMKVV Rv0405|M.tuberculosis_H37Rv PNIGHLEGAAGIAGLIKAVLMVERGSLLPSGGFTEPNPAIPFTELGLRVV TH_4458|M.thermoresistible__bu TNIGHLEAAAGIAGLIKVALALRHRMIPPTLNFTEPNPTIEFDKLPVRVA MMAR_1180|M.marinum_M SNIGHTQAAAGVAGLIKMIAALNHDSLPPTLNVDRPSPHVDWSAGTVRVL .*:** :.*:* **:** :.. : . .. : : ::* Mflv_0405|M.gilvum_PYR-GCK DTAMPWQPNG-RPRRAGVSSFGFTGTNAHVLIEEAPTDLAGPTEPTAPAE MAB_0939|M.abscessus_ATCC_1997 DKAIPWQANG-RPRRAGVSSFGFTGTNAHVLIEEAPQPQATP-------- MSMEG_0408|M.smegmatis_MC2_155 DEPVPWQTNG-RVRRAGVSSFGFTGTNAHVLVEEAPPQLHTADAAP---- MAV_1763|M.avium_104 DKAVPWQTNG-RPRRAGVSSFGFTGTNAHVLIEEAPQPVTTQ-------- Mvan_1003|M.vanbaalenii_PYR-1 AEPTPWRADG-RPRRAGVSSFGFSGTNAHVVLEEPPAQSADLRQPPTDGK Mb2956|M.bovis_AF2122/97 DTQTEWPATG-HPRRAGVSSFGFGGTNAHVVIEQGQE------------- MLBr_02357|M.leprae_Br4923 DKHMEWPDTG-HLRRAAVSSFGFGGTNAHVVIEQGPE------------- MUL_2019|M.ulcerans_Agy99 DELTDWPDTG-HPRRAGVSSFGFGGTNAHVVIEQGQE------------- Rv0405|M.tuberculosis_H37Rv DELQEWPVVAGRPRRAGVSSFGFGGTNAHVIVEEAGSVGADT-------- TH_4458|M.thermoresistible__bu QTLTPWPDDS-GRAVAGVSAFGFGGTNAHVVLAEAPQVR----------- MMAR_1180|M.marinum_M TEPVPWPVTD-HPRTAAVSSFGISGTNAHLILQQAPTPSSGS-------- * *.**:**: *****::: : Mflv_0405|M.gilvum_PYR-GCK PVDEDAAADPAPAPVEVLPLSARSPEALVALAQRYETWLTAH-PEADLAD MAB_0939|M.abscessus_ATCC_1997 --DEDDASTPQSAPVSVLPLSARSPEALAAVAQRYESWLAAH-PDVDLED MSMEG_0408|M.smegmatis_MC2_155 VEPAATAEAGTDDSPQVLALSARSPEALVELARRYDDWLSAT-PGLDIAD MAV_1763|M.avium_104 --DATPAAESDARPVDVLPLSARSPEALLALAQRYGEWLHAH-PDADIGD Mvan_1003|M.vanbaalenii_PYR-1 DGAAGLESATAPEPAGVLPISARSPEALTALARRYESWLTAH-PDADIAD Mb2956|M.bovis_AF2122/97 --VRPAPGQGLSPAVSTLVVAGKTMQRVSATAGMLADWMEGPGADVALAD MLBr_02357|M.leprae_Br4923 --LTPVTECSSNTAVSTLVVTGKTASRVAAMAGMLADWVEGPGAEVALAD MUL_2019|M.ulcerans_Agy99 --AASSPEADLTPALSTLVVAGKTPARVAATAGMLADWMEGPGAEVALAD Rv0405|M.tuberculosis_H37Rv -VSGRADVGGSGGGVVAWVISGKTASALAAQAGRLGRYVRAR-PALDVVD TH_4458|M.thermoresistible__bu --AAATADDHADGFVEILPLSARSQAALDALAERYES-ALTGG--VPPAD MMAR_1180|M.marinum_M PEPAGRPQHGAELGLPMWPVSARTPAGLAAQAERLHQ-HLLRHRDLDLTD ::.:: : * * Mflv_0405|M.gilvum_PYR-GCK VCRTAGTGRSHFEHRAALVVD-----SVESARIALTDLAQNRLRPGVVRG MAB_0939|M.abscessus_ATCC_1997 VCLTAGRGRSHFEHRAALVVD-----SIQTAREGLLELAQNRLRPGVVRG MSMEG_0408|M.smegmatis_MC2_155 VCHTAGVGRSHFEYRAALVVD-----SVERAREGLAALAEGRTPAGVVRG MAV_1763|M.avium_104 LCFTVGAGRAHFEHRAALVVD-----SVRSAREALADLADNRTRPGVARG Mvan_1003|M.vanbaalenii_PYR-1 VCYTAGAGRSHFEHRAALVVD-----SVDGARDLLAGLAEDRLGPGAVRG Mb2956|M.bovis_AF2122/97 VAHTLNHHRSRQPKFGTVVAR-----DRTQAIAGLRALAAGQHAPGVVNP MLBr_02357|M.leprae_Br4923 VAHTLNHHRSRHAKFGTVVAR-----DRIQAVAGLRALAAGKQAPGVVGQ MUL_2019|M.ulcerans_Agy99 VAHTLNHHRSRQARFGTVVAR-----ERAQAVAGLRALAANQHAPGVVNP Rv0405|M.tuberculosis_H37Rv VGYSLVSTRSVFDHRAVVVGQ-----TRDELLAGLAGVVAGRPEAGVVCG TH_4458|M.thermoresistible__bu LCHTAGARRAHHDHRLAVVG-----ASRAELIGALAAYRRGEPHPGVFTG MMAR_1180|M.marinum_M VGYSLGCTRTHHPHRAVVTVPAASPDPRAELLAALQALAAGDPHPQLVQH : : *: .:. * . . Mflv_0405|M.gilvum_PYR-GCK EHLNH--PTTAWMFTGQGSQYPGMARELFDTEPVFADTVTRCADAVADLL MAB_0939|M.abscessus_ATCC_1997 EHTNH--PTTAWLFTGQGSQYPGMARELFDAEPVFAETVTRCAEAVKDIV MSMEG_0408|M.smegmatis_MC2_155 EHVHR--PTTAWLFTGQGSQYPGMARELFDTQPVFAQTVRQCAEAVADML MAV_1763|M.avium_104 ECTDP--PTTAWLFTGQGSQYPGMARELFDAEPVFAETVTRCADAVDGLL Mvan_1003|M.vanbaalenii_PYR-1 VCGDP--PKTAWLFTGQGSQYPGMARELFDTEPVFRDTVTRCAEAIGDTL Mb2956|M.bovis_AF2122/97 AEGSPG-PGTVFVYSGRGSQWAGMGRQLLADEPAFAAAVAELEPVFVEQA MLBr_02357|M.leprae_Br4923 QDGTPG-SGTVFVYSGRGSQWAGMGRQLLADEPAFTAAVAELEPVFVVHA MUL_2019|M.ulcerans_Agy99 ADAPPE-PGTVFVYSGRGSQWAGMGRQLLADEPAFAAAVAELEPVFLAEA Rv0405|M.tuberculosis_H37Rv -VGKPA-GKTAFVFAGQGSQWLGMGSELYAAYPVFAEALDAVVDELDRHL TH_4458|M.thermoresistible__bu RSQSGHRSGVVFVFSDEGSQWRGMAQRLYAEDQVFRTALAECDRALRRHM MMAR_1180|M.marinum_M HLRSTSAGKTVFVFPGQGGQYPGMAAELYRRHQVFSRALDECDQALFGWT ..:::...*.*: **. .* .* :: . Mflv_0405|M.gilvum_PYR-GCK PRPLLDVMFAGGREAGVPPTETLRHTSFAQPALFAVEMGLARLWQSWGIV MAB_0939|M.abscessus_ATCC_1997 TRPLLEVMFATDRETGGKAGEALRHTSFAQPALFAVEMGLARLWQSWGIE MSMEG_0408|M.smegmatis_MC2_155 PRPLLDVLFATDRET----ADLLQHTSFAQPALFAVEMGLARLWQSWAIE MAV_1763|M.avium_104 PRPLTEVIFATDKDTGGEAGKTLRNTAFAQPALFAVEMGLARLWQSWGVE Mvan_1003|M.vanbaalenii_PYR-1 PRPLLEVLFDTDGDN----GQTLRHTSYAQPALFAIEMGLARLWQARGIE Mb2956|M.bovis_AF2122/97 GFSLHDVLAN---------GEELVGIEQIQLGLIGMQLALTELWCSYGVQ MLBr_02357|M.leprae_Br4923 GFSLHDVLAN---------GKELVGIEQIQLGLIGMQLTLTELWRSYGVQ MUL_2019|M.ulcerans_Agy99 GFSLHDVLAN---------GTELVGIEQIQLGLIGMQLTLTELWRSYGIQ Rv0405|M.tuberculosis_H37Rv RYPLRDVIWG-------HDQDLLNTTEFAQPALFAVEVALYRLLMSWGVR TH_4458|M.thermoresistible__bu EISPLSELLADPS------HSRMDEVTIASPALFAVQVALAALWQSWGVE MMAR_1180|M.marinum_M GWSVGAVVRGEPS------AMALQRVDVVQPVLFAVMVSLARTLISYGIE . : : . *:.: : * : .: Mflv_0405|M.gilvum_PYR-GCK PDVVLGHSVGQYAAACVAGVFSLEDGARLMAERGRLFGSLPEGGRMVAVF MAB_0939|M.abscessus_ATCC_1997 PDVVLGHSVGQYAAACVAGVFSIEDGARLIAERGRLFGGLPAGGRMVAVF MSMEG_0408|M.smegmatis_MC2_155 PDVVLGHSVGQYAAACVAGVFSLDDGARLMAERGRMFGSLPEGGRMVAVF MAV_1763|M.avium_104 PDVVLGHSVGQYAAACVAGVFSLEDGARLMAERGRLFGGLPDGGRMVAVF Mvan_1003|M.vanbaalenii_PYR-1 PDVVLGHSVGQYAAACVAGVFGLEDGARLVADRGRLFGGLPVGGRMVAVF Mb2956|M.bovis_AF2122/97 PDLVIGHSMGEVAAAVVAGALTPAEGLRVTATRSRLMAPLSGQGGMALLE MLBr_02357|M.leprae_Br4923 PDLVIGHSLGEVAAAVVAGALTAAEGLRVTATRSRLMAPLSGQGGMALLE MUL_2019|M.ulcerans_Agy99 PDLVIGHSMGEVAAAVVAGALTPAEGLRVTAVRSRLMAPLSGQGGMALLG Rv0405|M.tuberculosis_H37Rv PGLVLGHSVGELAAAHVAGALCLPDAAMLVAARGRLMQALPAGGAMFAVQ TH_4458|M.thermoresistible__bu PAAVIGHRMGEVAAAHVAGVLGLDDAAALLCGR-TRLSRLASTG------ MMAR_1180|M.marinum_M PDAVIGHSQGEIAAAYVAGVFTLEQAAKIVALRSAALADLSGTGGMASVL * *:** *: *** ***.: :. : . * : *. * Mflv_0405|M.gilvum_PYR-GCK ADAKR-VEQVAADFPRVSVGAYNGP-NTVLSGPGEDLEQIVGTFGEDGIR MAB_0939|M.abscessus_ATCC_1997 SDAKH-VEQIAGEFPRVSVGAYNGP-NTVLSGPGEDLEQAVARFQEEGIR MSMEG_0408|M.smegmatis_MC2_155 ADAEH-VEQVAGEFPRVSVGAYNGP-NTVLSGPGEDLEEIVERFEDEGIR MAV_1763|M.avium_104 ADAQY-VEELANDCPRVSVAAYNGP-NTVLSGPGADLEQIVARGASDGIR Mvan_1003|M.vanbaalenii_PYR-1 TDAEV-VEDFADEFPQVSVAAYNGP-NTVLAGPASDLEQIVAGCSGEGIR Mb2956|M.bovis_AF2122/97 LDAPT-TEALIADFPQVTLGIYNSPRQTVIAGPTEQIDELITRVRARDRF MLBr_02357|M.leprae_Br4923 LDAVE-TEALIVDYSQVTLAIYNSPRQTVIAGPTEQIDELIDRVRAQNRF MUL_2019|M.ulcerans_Agy99 LDASQ-TEALIADYPQVTLGIYNSPRQTVISGPTDQIDELITVVRARDRF Rv0405|M.tuberculosis_H37Rv AREDE-VAPMLG--HDVSIAAVNGPASVVISGAHDAVSAIADRLRGQGRR TH_4458|M.thermoresistible__bu -------------------------------------------------- MMAR_1180|M.marinum_M LGADEVAARLQPYGDALTVAAVNGPTHTIISGDPPAIEAFVAAGEADGIQ Mflv_0405|M.gilvum_PYR-GCK CTWLETSHAFHSELLDPVLDEFESYAAQLQFAAPTLPLVCNRTGAVLTG- MAB_0939|M.abscessus_ATCC_1997 CTWLETSHAFHSELLDPILDEFESYAAQVQFAAPTLPLVCNRTGAVLTA- MSMEG_0408|M.smegmatis_MC2_155 CTWLATSHAFHSELLDPVLDEFEAYAAQFQFAAPTLPLVCNRTGAVLTG- MAV_1763|M.avium_104 CSWLETSHAFHSELLDPVLDEFESYAAHLDFAVPTLPLVCNRTGTVLTT- Mvan_1003|M.vanbaalenii_PYR-1 TTWLDTSHAFHSALLDPVLDEFESCAARLAYAAPTRPLVCNRTGAVVTG- Mb2956|M.bovis_AF2122/97 ASRVNIEVAPHNPAMDALQPAMRSELADLTPRTPTIGIISTTYADLHTQ- MLBr_02357|M.leprae_Br4923 ASRVNIEVAPHNPAMDALQPQMRSELADVAPRTPTIPILSTTYADLGSC- MUL_2019|M.ulcerans_Agy99 ATRVNIEVAPHNPAMDALQPQMRSELADLAPRTPTIPIISTTYADLGAAR Rv0405|M.tuberculosis_H37Rv VHRLAVSHAFHSALMEPMIAEFTAVAAELSVGLPTIPVISNVTGQLVAD- TH_4458|M.thermoresistible__bu ----------------AVREGLDGLLANLRPDDPRIPLYSTVTGDAVTG- MMAR_1180|M.marinum_M IRSITVDYASHCGQVEPARERLLGELAGLTPAPGRIALYSTVHGVTSDQP . : . * . : .. . Mflv_0405|M.gilvum_PYR-GCK --QTSLDAQYWRRHSRQPVQFAESVRTVAALG---CSVLMEIGPQPVLTG MAB_0939|M.abscessus_ATCC_1997 --QTPIDGQYWRRHSRQPVQFAESVRTVAALG---CSVLMEIGPQPVLTG MSMEG_0408|M.smegmatis_MC2_155 --QTPLDAQYWRRHSRQPVQFAESVRTVAALG---CSVLMEIGPQPVLTG MAV_1763|M.avium_104 --ETPLDARYWRRHSRQPVQFAESVRTVAALG---CTVLMEIGPQPVLTG Mvan_1003|M.vanbaalenii_PYR-1 --PGVIDAQYWRRHARQPVQFAESVRTLADLG---CSVLMEIGPQPFLIA Mb2956|M.bovis_AF2122/97 ---PVFDAEHWATNMRNPVHFQQAIASAGSGADGAYHTFIEISAHPLLTQ MLBr_02357|M.leprae_Br4923 ---PVFDAQHWATNMRNPVHFQQAIMTAGT----DHRTFIEISAHPLLTQ MUL_2019|M.ulcerans_Agy99 ESGPTFDAEHWAINMRNPVHFQQAITAAAT----DKHNFIEISAHPLLTQ Rv0405|M.tuberculosis_H37Rv ---DFASADYWARHIRAVVRFGDSVRSAHCAG---ASRFIEVGPGGGLTS TH_4458|M.thermoresistible__bu ---RGFGAAHWMENLHSPVRFSAAVRRLLGRG---HDAFLEISAHPMLLS MMAR_1180|M.marinum_M LDTTTMTADYWYANLRQPVRFYDSIKVLLAAA---EQVFVEISPHPVLAP . :* : : *:* :: ::*:.. * Mflv_0405|M.gilvum_PYR-GCK AAVQVWPEHL---AAPRAIASLRKGVADRRQIADALAAAYIGGHKPDFAA MAB_0939|M.abscessus_ATCC_1997 AAVQVWPEHL---APPRAIVSLRKGVEDRRQIADALASAYVSGHRPNFAA MSMEG_0408|M.smegmatis_MC2_155 AAVQVWPEHM---AAPRAVASLRKGVADRRQIADALASAYVGGHRPDFAA MAV_1763|M.avium_104 AAVQVWPEHL---AAPRAIVSLRKGVGDRRQIAEGLAAAYVSGHRPEFAA Mvan_1003|M.vanbaalenii_PYR-1 AALRVWPESA---ATPRAIPSLRKGPDARRQLAEAVAAAYIAGHRLDFTG Mb2956|M.bovis_AF2122/97 AIIDTLHSAQ---PGARYTSLGTLQRDTDDVVTFRTNLNKAHTIHPPHTP MLBr_02357|M.leprae_Br4923 AITDTLH-------GTRCISIGTLQRDADDTVTFHTNLNNVHTVHPPHTP MUL_2019|M.ulcerans_Agy99 AILETLHTVQ---PGSKYTSLGTLQRDSDDTIVFRTNLDTVRTA-PPQTP Rv0405|M.tuberculosis_H37Rv LIEASLAD-----AQIVSVPTLRKDRPEPVSVMTAAAQGFVSGMGLDWAS TH_4458|M.thermoresistible__bu AVQEDAADLG---RSCTTLVSMRRGECGRDVLMTSLAALYASGHAVDWAR MMAR_1180|M.marinum_M AITDTLAASNGQRPGSVVIPTLHRERPDLDALTTTLARLQVHGRGPAWPV : . Mflv_0405|M.gilvum_PYR-GCK LHEQRG-VRLELPTYPFQRRRFWPKSAGMA-IDGRVGASAGSGILGSGKD MAB_0939|M.abscessus_ATCC_1997 LQRHPR-RTVELPTYPFQRRRFWPKSSGTA-IEG--GGGLPSGILGRGED MSMEG_0408|M.smegmatis_MC2_155 VHRQPR-RPVELPTYPFQRRRFWPKASSIA-VDG---GTAASGILGSGKD MAV_1763|M.avium_104 LHRRPR-RKLELPTYPFQRRRFWPKASGIAGIDG--QGAAASGLLGSAKE Mvan_1003|M.vanbaalenii_PYR-1 HDGGPH-RRLPLPTYPFQHRSYWPKTAGIR-SDG----SSGSGLLGSAQD Mb2956|M.bovis_AF2122/97 HPPEP---HPPIPTTPWQHTRHWITTKYPAGSVG--SAPRAGTLLGQHTT MLBr_02357|M.leprae_Br4923 HPAEP---HVTIPSTPWQHTRHWIPRKRSVNSIG--LAPQVGTLLGQHT- MUL_2019|M.ulcerans_Agy99 HPPEP---HPQIPTTPWHHTHHWIDTPAVASRSA--STPDKD-------- Rv0405|M.tuberculosis_H37Rv VFSGYRPKRVELPTYAFQHQKFWLAPAPSVSDPT---------------- TH_4458|M.thermoresistible__bu VHPHG-SHCTAAPTYPWQRQRFWLDIDRCDTGDGAGTG-----------G MMAR_1180|M.marinum_M VYPH--ARPVPLPTYPFQHHRYWLTTGPGNDAAGLGLDRVGHPLLGAITA *: .::: .* Mflv_0405|M.gilvum_PYR-GCK LASGDSVYTSRLSVKTQPWLSDHVIYGTVVVPGATYAAMALAAVGTPAHA MAB_0939|M.abscessus_ATCC_1997 LASGDSVYISRLSVRSQPWLSDHVIYGTVVVPGATYAAMALAAVGTPARA MSMEG_0408|M.smegmatis_MC2_155 LASGDTIYTSRLSVKSQPWLADHVIYGTVVVPGATYAAMALAAVGTPARL MAV_1763|M.avium_104 LASGDSVYTSRLSVKSQPWLADHVIYGTVVVPGATYAAMALAAVGPPARV Mvan_1003|M.vanbaalenii_PYR-1 LASGDIVHTSRLSVKTQPWLSDHVIYGTVVVPGATYAAMALAAMPTPARV Mb2956|M.bovis_AF2122/97 VATVSASPPSHLWQARLAPDAKPYQGGHRFHQVEVVPASVVLHTILSAAT MLBr_02357|M.leprae_Br4923 --AVSGILPIHLWQARLAPQAKPYRGWHRVHGVEVVPASIVLRTILCAAA MUL_2019|M.ulcerans_Agy99 --AAGSSEPSVSGDSDDAVDSCHYR------------------------- Rv0405|M.tuberculosis_H37Rv -------------------------------------------------- TH_4458|M.thermoresistible__bu TAERTVVPAP-------------------------------LPAPSASAA MMAR_1180|M.marinum_M LADRDEVIATGRLALGVQGWLGAHRVGDVVVLPGTAFVDMALAVGDYVGC Mflv_0405|M.gilvum_PYR-GCK KDVFFYEPIILPEKSSREVQLTVHPSVDGE-SKFQVHSRPYGERGAEWAL MAB_0939|M.abscessus_ATCC_1997 KDVFFYEPIILPEKSSREVQLTLHPLEDGSGSKFQVHSRPYGERDVDWSL MSMEG_0408|M.smegmatis_MC2_155 KDVFFYEPIILPEKASREVQLTLHPADGGSVLSFQIHSRPYGERGADWSL MAV_1763|M.avium_104 QNVYFYEPIILPDKASREVQLSLHPLQEGG-WSFRVDSRPYGVPDAEWSL Mvan_1003|M.vanbaalenii_PYR-1 QEVFFYEPIILGDKDSREVQLMLHRTDDADGWTFEVHSRPYGDRDADWSR Mb2956|M.bovis_AF2122/97 ELGYSALSEVRFEQPIFADRPRLIQVVADNRAISLASSPAAGTPSDRWTR MLBr_02357|M.leprae_Br4923 ELGYSTLFEIRFEQPIFANLPRLIQVVVDNQLISLASSPATETPQHRWTR MUL_2019|M.ulcerans_Agy99 -------------------------VGWPTKPLADAKASTETASGTRWLV Rv0405|M.tuberculosis_H37Rv ------------------------------------AAGQIGASDGGAEL TH_4458|M.thermoresistible__bu PTVDEVLLCA-------------------DQRERREL------------- MMAR_1180|M.marinum_M PAVAELVLHAPLVLAEDTPTDIQIGVAGADGGARRAFNVHARTGTGHRGE Mflv_0405|M.gilvum_PYR-GCK NAEGVVASGVGD---SPAAAGDLEDPVDEAIERLNRMRPQELFETFADLE MAB_0939|M.abscessus_ATCC_1997 NAEGTVVTGIGDDAEPAPEAAEPAEPVDAAIERMERMRPMELFEIFADLE MSMEG_0408|M.smegmatis_MC2_155 NAEGTVDTAGSD---PDAAADEQSDPVDEVIERLERMRPQDLFETFADLE MAV_1763|M.avium_104 NADGTVVAGIED-----EPAADPADHIDAVIERLDRNRPQLLFDSFAESE Mvan_1003|M.vanbaalenii_PYR-1 NASGTVAAGVGD-----AAPDAAADPVDNAIERLTRTRPQQLFDAFADND Mb2956|M.bovis_AF2122/97 HVTAQLSSSPSD-------------------------------------- MLBr_02357|M.leprae_Br4923 HVTAQLSSASAR-------------------------------------- MUL_2019|M.ulcerans_Agy99 FADAELGAELGL-------------------------------------- Rv0405|M.tuberculosis_H37Rv LASSGFAARLAG-------------------------------------- TH_4458|M.thermoresistible__bu -----------------------------------------LESYLRDR- MMAR_1180|M.marinum_M TGWVLHASGILA------AEPAAAGQPPMAALPVTEFDVADFYQRLADRG Mflv_0405|M.gilvum_PYR-GCK LAWGPTWSGSLKSLWLGEGEAIGDILVGAELAEQLGTEPMHPVLMDLCTG MAB_0939|M.abscessus_ATCC_1997 LAWGPTWSGSLKSLWLGEGEAIGDVLVGEELAEQLGTEPMHPVLMDLCTG MSMEG_0408|M.smegmatis_MC2_155 LAWGPTWSGSLKSLWLGDGEAVGDILVGAELAEQLGSEPMHPVLMDLCTG MAV_1763|M.avium_104 LEWGTTWSTSLKSLWMGDGEAVGDVTVGDELAEHLGTEPMHPVLLDLCTG Mvan_1003|M.vanbaalenii_PYR-1 LAWGPAWCSSLRSLWVGTGEAVGDIAVGAELGEHLGREPIHPVLLDLCTG Mb2956|M.bovis_AF2122/97 --------------------SASSLNEHHRANGQPPERAHRDLIPDLAEL MLBr_02357|M.leprae_Br4923 --------------------SAVPSDHPDQING--HLEVISDPIPDVASL MUL_2019|M.ulcerans_Agy99 --------------------AAG--------------------------- Rv0405|M.tuberculosis_H37Rv -------------------------------------------------- TH_4458|M.thermoresistible__bu --------------------------VAAELG-------VLPPLLDVAAP MMAR_1180|M.marinum_M LHYGPPFCSVLGIGHEPADPDHIYAEVALPAGTDITGYGIHPALLDAALH Mflv_0405|M.gilvum_PYR-GCK VAFPAFPALLAAEQGVNDLYLPLRYGQVSLQEKMPRRFYCRATWHEAPLD MAB_0939|M.abscessus_ATCC_1997 VAFPAFPALLAAEQGVNDLFLPLRYGQVTLKEKMPRRFYCRARWHESPLD MSMEG_0408|M.smegmatis_MC2_155 VAFPAFPALLAAEQGVNDLFLPLRYGQVTLAEKMPRRFYCRARWHRSALD MAV_1763|M.avium_104 VVFPAFPALLAAEQGFNDLLLPLRYGQVSLREKMPRRFYCRGKWRPSALD Mvan_1003|M.vanbaalenii_PYR-1 IAGAALLAAAAQTDADPELFLPLRYGRVEVRERMPRRFYCRARWQTGGID Mb2956|M.bovis_AF2122/97 LAMRGIDGLPFSWTVASWT---QHSSNLTVAIDLPEALPE---------- MLBr_02357|M.leprae_Br4923 LALCGVDGLPFEWSVKSWAKKTQQSTSRTVEIEFPDTLPD---------- MUL_2019|M.ulcerans_Agy99 -------------------------AQTRVDVIDPSALTE---------- Rv0405|M.tuberculosis_H37Rv -------------------------------------------------- TH_4458|M.thermoresistible__bu ----------------------LSTLGIDSLTAAELRARVERDLG----- MMAR_1180|M.marinum_M PMAAALGAGADSESAAVRLPFVLSGVTLHATAATRLQVWLTRSSADTFTL Mflv_0405|M.gilvum_PYR-GCK SETQVFDLEYLDRDGRHLGGVREFTVKRAPREALLRGLGGDATRLLYTLG MAB_0939|M.abscessus_ATCC_1997 SETQVFDLDYLDRDGRHLGGIREFTVKRAPREALLRGLGGDATRLLYTLG MSMEG_0408|M.smegmatis_MC2_155 SETQVFELEFVDLGGRALGGIREFTVKRAPREALLRGLGGDATRLLYTLG MAV_1763|M.avium_104 SETQVFDIDFIDRDGRHLGGIREFTVKRAPREALLRGLGGDATRLLYTLG Mvan_1003|M.vanbaalenii_PYR-1 SETQVFDLDFLDHDGRNLGGIREFTVKRAPREALLRGLGADATRLIYRVG Mb2956|M.bovis_AF2122/97 -------------------------------------------------- MLBr_02357|M.leprae_Br4923 -------------------------------------------------- MUL_2019|M.ulcerans_Agy99 -------------------------------------------------- Rv0405|M.tuberculosis_H37Rv -------------------------------------------------- TH_4458|M.thermoresistible__bu ----------IVIPVAQLLNGPSVSDLAEWISTTMVG---FGSTTPEPES MMAR_1180|M.marinum_M YASDPAGAPVISIDTVVVRALPDLATLTPPTTATSSGRGLWELAWPPLSS Mflv_0405|M.gilvum_PYR-GCK WHEVPVP----ESGDGAAPQGTWLIGGFDELAVSVPG--CIPADR-TNPE MAB_0939|M.abscessus_ATCC_1997 WHEVAVPPVAGEGEESAASIGTWLIAGFDELAAKVPG--CIPLNRETDPE MSMEG_0408|M.smegmatis_MC2_155 WHEVPPP------PSADDAVGTWLIAGFDELAAKVPG--CVPIDRNTDLQ MAV_1763|M.avium_104 WHEVPPQP---SNDGVANPSGTWLIAGFDELGAQLPG--CIPFDRNTDPE Mvan_1003|M.vanbaalenii_PYR-1 WRETSPPVR---DDGALGPSSTWLVAGLDALADDVPGSIRIGFDRIWDPD Mb2956|M.bovis_AF2122/97 -------------------------------------------------- MLBr_02357|M.leprae_Br4923 -------------------------------------------------- MUL_2019|M.ulcerans_Agy99 -------------------------------------------------- Rv0405|M.tuberculosis_H37Rv -------------------------------------------------- TH_4458|M.thermoresistible__bu AGVPGRSRPPD-----------GAVASGSGDGGR---------------- MMAR_1180|M.marinum_M AGAPGAAVVAEPPAWVVVAEDPDAVSAGLRNGVRRPD------------- Mflv_0405|M.gilvum_PYR-GCK SLR-------------QLLTDAHGRGLPFSGVVWRAARSDGDES--DAEV MAB_0939|M.abscessus_ATCC_1997 LLG-------------EVLVAAKERGVPFSGVVWRAAGPGATES--TTES MSMEG_0408|M.smegmatis_MC2_155 VLG-------------EVLSQAHARGAGFSGVVWRCATPGRKESGSASAE MAV_1763|M.avium_104 SFG-------------QLLARAEDRGGPVTGIVWRATQSGGRES--SAES Mvan_1003|M.vanbaalenii_PYR-1 RDGRVVLDPADDEHWRRLFALADERRAPVAGVVLGVTGRARPEE-PSADF Mb2956|M.bovis_AF2122/97 -------------------------------------------------- MLBr_02357|M.leprae_Br4923 -------------------------------------------------- MUL_2019|M.ulcerans_Agy99 -------------------------------------------------- Rv0405|M.tuberculosis_H37Rv -------------------------------------------------- TH_4458|M.thermoresistible__bu -------------------------------------------------- MMAR_1180|M.marinum_M --------------------------LDAVRPCPPVVIWSLSPPDLRGDD Mflv_0405|M.gilvum_PYR-GCK AARLEAEIAELLGAVHTVQ---GGEVKLPGGLWIVTERAVATESGEPVDP MAB_0939|M.abscessus_ATCC_1997 AARLEGEIAHLLSAVHTVQNSAQNGVKLPGGLWIVTERAVATESGEPVDP MSMEG_0408|M.smegmatis_MC2_155 SARLEAEITNLLSAVHAAQ---GPSVKLPGGLWIVTEHGVACESGEPVDP MAV_1763|M.avium_104 VARLETEIAGLLTAVHALQNADGSAVKLPGGLWIVTERGVATESGEPVDP Mvan_1003|M.vanbaalenii_PYR-1 AARLEAQIRDVLGAVHSLS---ALGAKPAAGLWIVTERAVAAEAGEPVDP Mb2956|M.bovis_AF2122/97 ---------------------GSTGPLLDAAVHLAALSDVADSRLYVPAS MLBr_02357|M.leprae_Br4923 ---------------------GAIAPLLDAAILIPALADVTETQFYVPAS MUL_2019|M.ulcerans_Agy99 ---------------------GSE--------LLAALAGVEHVVYAPPA- Rv0405|M.tuberculosis_H37Rv ---------------------RSADEQLAAAIEVVCEHAAAVLGR----- TH_4458|M.thermoresistible__bu -------------------------------------------------- MMAR_1180|M.marinum_M DAVVSSMHSLTRHALAAVAAWLARPDTAETVLVVLTCRAVAINAYERAPN Mflv_0405|M.gilvum_PYR-GCK VQAALWGFGRTAINEEPALRCRLVDCDGSPQAVQALAALLSTP-VDEPEL MAB_0939|M.abscessus_ATCC_1997 VQAALWGFGRTTINEEPALRAKLVDGDGSPEAVQALARLLVTP-VDEPEI MSMEG_0408|M.smegmatis_MC2_155 VQAALWGFGRTTINEEPALHCRLVDCDGSSEAVDLLAALLAAPGIQEPEI MAV_1763|M.avium_104 VQAALWGLGRTIVNEEPALRCRLVDSDGSEQAVRSLAGLLGAP-LDEPEL Mvan_1003|M.vanbaalenii_PYR-1 VQSALWGLGRTLIAEEPGLRCLLVDLDGSEDAGPALARLLGAP-GDEPEL Mb2956|M.bovis_AF2122/97 IEQISLGDVVTGPRSSVTLNRTAHDDDGITVDVTVAAHGEVPS------- MLBr_02357|M.leprae_Br4923 IKQVWLGDTATGPCGAVTLNRTACDDDGITVDVTVADGSGVPL------- MUL_2019|M.ulcerans_Agy99 ---------------------------GKSLDVNAAY------------- Rv0405|M.tuberculosis_H37Rv -------------------------------------------------- TH_4458|M.thermoresistible__bu -------------------WIELLN-QMPEVSDDTVDELLR--------- MMAR_1180|M.marinum_M PAQAAVWALLHSAQSEHPGRIRLVDTDHAASSTDTLLQLLGSCTGTGGEP Mflv_0405|M.gilvum_PYR-GCK AVRQGKLLASRLLPWSRSGHLTVPRGGDYVLAPTERGAIDNLRLTDSEVP MAB_0939|M.abscessus_ATCC_1997 AVRQGKLLASRLLPWSRTGHLTVPRGSDYVLAPTERGAIDNLRITEKEVP MSMEG_0408|M.smegmatis_MC2_155 AVRQGKLLASRLLPWARSGHLTLPRGGDFVLAPTERGAIDNLRLTETDVP MAV_1763|M.avium_104 AVRQGKLLASRLLPWARSGHLAVPRGTDYVLAPTERGAIDNLRLIEQEAP Mvan_1003|M.vanbaalenii_PYR-1 ALRQGRLLVPRLLPWSRSGQLAIPRGTDYVLAPTERGVLDNLRVSETEVT Mb2956|M.bovis_AF2122/97 ------------------------------------LSMRSLRYRALDFG MLBr_02357|M.leprae_Br4923 ------------------------------------ALMRSLRYRALDLD MUL_2019|M.ulcerans_Agy99 -------------------------------------------------- Rv0405|M.tuberculosis_H37Rv -------------------------------------------------- TH_4458|M.thermoresistible__bu -------------------------------------------------- MMAR_1180|M.marinum_M QLALRAGVAHMPRLAPARALTPPPTPHWRLITSGSGDLADLTLAPTPAPA Mflv_0405|M.gilvum_PYR-GCK PPAEGYVQVRVEAAGLNFRDVLNVLGLYPGDPGPIGGDFAGTVTQLGEGV MAB_0939|M.abscessus_ATCC_1997 APDEGYVQVRVEAAGLNFRDVLNVLGLYPGDPGPIGGDFAGIVTQLGEGV MSMEG_0408|M.smegmatis_MC2_155 EPDEGYVQVRVEAAGLNFRDVLNVLGLYPGDPGPIGGDFAGTVTQLGAGV MAV_1763|M.avium_104 PPAEGCVQVRVEAGGLNFREVLNVLGLYPGDPGPLGGDFAGTVTQLGSGV Mvan_1003|M.vanbaalenii_PYR-1 APPEGHVQVRVEAAGLNFRDVLNALGLYPGDPGPIGGELAGVVTAPGPDV Mb2956|M.bovis_AF2122/97 LDVGRAQPPASTGPVEAYCDATNFVHTIDWQPQTVPDATHPGAEQVTHPG MLBr_02357|M.leprae_Br4923 NAQQDYSTVFVESHVDALTDARNFVHAIDWQPRTDLDCSN---TPVASSG MUL_2019|M.ulcerans_Agy99 -------------------------------------------------- Rv0405|M.tuberculosis_H37Rv -------------------------------------------------- TH_4458|M.thermoresistible__bu ---------QLLAAGENHDDTQLH-------------------------- MMAR_1180|M.marinum_M ELGPGQIRVQIRAAGLNSDDVAVASAATSHRDAGGEGQQDHQGLGVEAAG Mflv_0405|M.gilvum_PYR-GCK TGLDVGQRVYGSMQGAFASRFNVPGQFLAPIPDGVSAVEAATI------- MAB_0939|M.abscessus_ATCC_1997 TGVEVGQRVYGSMQGAFGSRFNVPAQFLAPIPDGISGVEAATI------- MSMEG_0408|M.smegmatis_MC2_155 SGLEIGQRVYGSMQGAFASRFNVPAQFLAPIPDGIGAVEAATI------- MAV_1763|M.avium_104 TGLEVGTRVYGFMQGAFASRFNVPVQLLAPIPDGVSAVDAATI------- Mvan_1003|M.vanbaalenii_PYR-1 DGFDVGQRVFGFAVGAFASRVNVPVQFLAPVPEGISAVAAATT------- Mb2956|M.bovis_AF2122/97 PVAIIGDDGAALCETLEGAGYQPAVMSDGVSQARYVVYVADSD------- MLBr_02357|M.leprae_Br4923 SVAVIGDARAGFGLLLKEAGYTLAAPADGVSEVRYVVYVADPH------- MUL_2019|M.ulcerans_Agy99 -------------QLFHQVRRLVAVMTKASLTAKLLLVTRNAQ------- Rv0405|M.tuberculosis_H37Rv ------DGAAGLDAGQAFADSGFNSLSAVELRNRLTAVTAVTL------- TH_4458|M.thermoresistible__bu -------------------------------------------------- MMAR_1180|M.marinum_M IVIDTAGDVDDLAPGDAVMGIFPNNAFAPTAATDHRAVVAIPPGWSCPQA Mflv_0405|M.gilvum_PYR-GCK ----PAAALTVRLSFDWAQVKSGDKVLIHAASGGVGLAAVQMAQQCGAEV MAB_0939|M.abscessus_ATCC_1997 ----PAAALTVRLSFDWAQLKPGDKVLIHAASGGVGLAAIQMAQQFGAEV MSMEG_0408|M.smegmatis_MC2_155 ----PAAALTVRLAFDWAQLKPGDKVLIHAASGGVGLAAIQMAQQSGAEV MAV_1763|M.avium_104 ----PAAALTARLAFDWAQLKPGDRVLIHAASGGVGLAAIQLAQRHGATV Mvan_1003|M.vanbaalenii_PYR-1 ----PAAVLTAGLAFDWAALRAGDRVLIHAASGGVGLAAVQLARQRGATV Mb2956|M.bovis_AF2122/97 ----PAGADETDVDFAVRICTEITGLVRTLAERDADKPAALWILTRGVHE MLBr_02357|M.leprae_Br4923 ----PATTAETDVDFAVRITAEISDLVRALAKREPGKPVALWIVTRGVYE MUL_2019|M.ulcerans_Agy99 ----PIAEGD---------------------------------------- Rv0405|M.tuberculosis_H37Rv ----PATAIFDHP------------------------------------- TH_4458|M.thermoresistible__bu -------------------------------------------------- MMAR_1180|M.marinum_M ASVPVAFVTAYSALIDIAALRAGQRVLIHSGAGAVGRAAIRIAQHLGAEV Mflv_0405|M.gilvum_PYR-GCK YATASTFKRATLRKLGVKHVYDSRTTDFAE-QILADTDGAGVDVVLNSLT MAB_0939|M.abscessus_ATCC_1997 FATASTFKRATLRKLGVKYVYDSRTTDFAD-QILADTDGAGVDVVLNSLT MSMEG_0408|M.smegmatis_MC2_155 FATASTFKRSTLRRLGVKYVYDSRTTDFAD-QILADTNGAGVDVVLNSLT MAV_1763|M.avium_104 FATASTYKRATLRKLGVEYVYDSRSTDFAD-QILADTDGAGVDVVLNSLT Mvan_1003|M.vanbaalenii_PYR-1 FATASGYKRPMLRAMGVDHVYDSRTTDFAD-QILADTDGAGVDVVLNSLT Mb2956|M.bovis_AF2122/97 SVAPSALRQSFLWGLAG--------------------------------- MLBr_02357|M.leprae_Br4923 SVASSALRQSFLWGFGG--------------------------------- MUL_2019|M.ulcerans_Agy99 ---RANPAHGVLWGLGR--------------------------------- Rv0405|M.tuberculosis_H37Rv --TPTELAQYLITQIDG--------------------------------- TH_4458|M.thermoresistible__bu -------------------------------------------------- MMAR_1180|M.marinum_M FATADPAEQHILRGLGIPEDHIASSRARDFGDTLAAATGGRGMDVVLNDL Mflv_0405|M.gilvum_PYR-GCK SEGFIEATLRATAQHGRFAEIAKRDIWTVEQMAAARPDLAYEIVALDTVM MAB_0939|M.abscessus_ATCC_1997 SEGFIEATLRATAKNGRFAEIAKRDIWTTEQMAQSRPDIAYEIVALDTVM MSMEG_0408|M.smegmatis_MC2_155 SAGFVEATLKATAQGGRFAEIAKRDIWSHEQMAEARPDIAYEIVALDTVM MAV_1763|M.avium_104 NEGFIEATVRATAQHGRFVEIAKRDIWTREQMAAARPDIAYEIVALDWAC Mvan_1003|M.vanbaalenii_PYR-1 NDGFVAATVRATARNGRFAEIAKRDIWSPEQMAAARPDIDYEVLALDAVM Mb2956|M.bovis_AF2122/97 ------------------------------VIAAEHPELWGGLVDLAIN- MLBr_02357|M.leprae_Br4923 ------------------------------VIAAEHPEMWGGLVDLAASA MUL_2019|M.ulcerans_Agy99 ------------------------------TIALEHPEIWRGIIDLDESM Rv0405|M.tuberculosis_H37Rv -------------------------------------HGSSAAAAANPAE TH_4458|M.thermoresistible__bu -------------------------------------------------- MMAR_1180|M.marinum_M RGDLVDASLRLLAAPGCFVEIARRDIREATDVAQTHPGLRYVVYDISTAT Mflv_0405|M.gilvum_PYR-GCK F--TEPDRIRDLLTEVSAGLRDGAWTPLPAEVYPLTEARAAFRRMQQARH MAB_0939|M.abscessus_ATCC_1997 F--QEPDRIRVLLTEVSEGLAKGEWTPLPAEIYPLTEARTAFRRMQQARH MSMEG_0408|M.smegmatis_MC2_155 F--TEPDRIRDLLTEVSDGMARGEWTPLPAEIYPITEARSAFRRMQQARH MAV_1763|M.avium_104 V--EQPEHIHALLTEVSDGLASGEWRPLPAEIYPLAEAKTAFRRMQQARH Mvan_1003|M.vanbaalenii_PYR-1 Q--QDPDRIQLLLADLADSLARGETAPLPFEAYPLAEATTAFRRMQQARH Mb2956|M.bovis_AF2122/97 ------DDLGEFGPALAELLAKPSKSILVRRDGVVLAPALAPVRGEPARK MLBr_02357|M.leprae_Br4923 LGADRDDILDQFGPTLASLLQTPTRSIVVLRDGVVLAPTLVPIRSEPVRK MUL_2019|M.ulcerans_Agy99 P-----AELAAP-KILGEVTGTDGEDQVVYRCGSRHVPRLQ-RRTAPAVA Rv0405|M.tuberculosis_H37Rv R----IDALTDLFLQACDAGRDADGWKMVALASNTRERMSSPVRNN---- TH_4458|M.thermoresistible__bu -------------------------------------------------- MMAR_1180|M.marinum_M P-----ERLQRTWAAVSELINAAVIEPPPVTAYGLLRARQAFRDISEARP Mflv_0405|M.gilvum_PYR-GCK IGKIVVQIPNPLQPQPDRSYLITGGLGAIG-LHTAGYLAQLGAGDIVLTS MAB_0939|M.abscessus_ATCC_1997 IGKIVCQMPNPLAPRPDRTYLITGGLGAIG-LHTAAYLAQLGAGDIVLTS MSMEG_0408|M.smegmatis_MC2_155 IGKIVLQVPKPLQPQQDRSYLITGGLGAIG-LHTAAYLAQLGAGDIVLTS MAV_1763|M.avium_104 IGKIVLQMPKPLQPRGDRSYLITGGLGAIG-LHLAAYLAQLGAGEIVLTS Mvan_1003|M.vanbaalenii_PYR-1 TGKIILQMPKPLQPHGDRSYLITGGLGALG-LHAAAYLAQLGAGDIVLTG Mb2956|M.bovis_AF2122/97 S----------LQCRPDAAYLITGGLGALG-LLMADWLADRGAHRLVLTG MLBr_02357|M.leprae_Br4923 S----------LQCKSDGAYLITGGMGALG-LLMADWLADRGARRLVLMG MUL_2019|M.ulcerans_Agy99 P----------VTLDPNSSQLVIGATGNIG-PYLIRQLAQMGAKTVVAVS Rv0405|M.tuberculosis_H37Rv --------------VSKNVALLADGISDVV-VICIPTLTVLSD------- TH_4458|M.thermoresistible__bu -------------------------------------------------- MMAR_1180|M.marinum_M SGKVVLIAP--AALDPAGTVLITGGTGMLGGLFAEHLLTHYGVRRLLLTS Mflv_0405|M.gilvum_PYR-GCK RRAP-------------DAAAQQAIADIADRTKARLHVFTADVGVEADVA MAB_0939|M.abscessus_ATCC_1997 RRAP-------------DTDAQRVIGEITERSKTRIHVFTADVGAESEVA MSMEG_0408|M.smegmatis_MC2_155 RRDP-------------DESAQRAIDEITERHKCRIHTYAADVGDEAQVA MAV_1763|M.avium_104 RRAP-------------DAAAWRAIDDITERYRCRVHTFAADVGDAAQVE Mvan_1003|M.vanbaalenii_PYR-1 RRMP-------------DAATERAISEIAERYHCRIHTFAADVGDESAVR Mb2956|M.bovis_AF2122/97 RTPLPPRRDWQLDTLDTELRRRIDAIRALEMRGVTVEAVAADVGCREDVQ MLBr_02357|M.leprae_Br4923 RTPLPPRRDWELDTLDAGLRQKIDAICALEMRGVTVEAVAVDVGHHDDVQ MUL_2019|M.ulcerans_Agy99 RNPG---------------QRLQELAESLAAEGTNLVIEAADATDEAAMT Rv0405|M.tuberculosis_H37Rv ---------------------QREYRDIANAMTGRHSVYSLTLPGFDSSD TH_4458|M.thermoresistible__bu -------------------------------------------------- MMAR_1180|M.marinum_M RRGPSGVG-------------AAELAERLNGLGAQVTISACDCADPAQLA Mflv_0405|M.gilvum_PYR-GCK ALLER-IRAELPPLAGVAHLAGVLDDALLSQQSVERFRTALAPKAFGAVH MAB_0939|M.abscessus_ATCC_1997 GLLER-IRAELPPLAGVAHLAGVLDDALLGQQSVERFRTTLAPKAFGAEY MSMEG_0408|M.smegmatis_MC2_155 DLLAR-IRAELPPLAGIAHLAGVLDDALLSAQNPERFRTTLAPKAYGASH MAV_1763|M.avium_104 QLLAR-IRAELPPLAGVAHLAGVLDDALLSQQSPERFRVALAPKAFGASY Mvan_1003|M.vanbaalenii_PYR-1 DLLER-IRTELPPLAGVAHLAGVLDDALLPQQSPERFRTTLAPKAFGAWH Mb2956|M.bovis_AF2122/97 ALLAARDRDGAAPIRGIIHAAGITNDQLVTSMTGDAVRQVMWPKIGGSQV MLBr_02357|M.leprae_Br4923 ALLAKRDRDGAAPIRGIIHAAGVTNDQLVTNMTDDPVRQVMWPKIAGCQV MUL_2019|M.ulcerans_Agy99 ALFDRFGAD-LPPLDGIYLAAFAGGPVLLNEMTDADVRAMFAPKLDAAAL Rv0405|M.tuberculosis_H37Rv ALPQNADMIVETVSNAIIDVVGGSCRFVLSGYSSGGVLAYALCSHLSVKH TH_4458|M.thermoresistible__bu -------------------------------------------------- MMAR_1180|M.marinum_M ALIDS--IPTEHPLTAVIHAAGVLDDAVTSQLTAQQLDTVLAAKADSAWH Mflv_0405|M.gilvum_PYR-GCK LDRLTRVDDLDFFLVSSSVSSLFGSPGQSNYATANAFLDGLVAQRRAQGL MAB_0939|M.abscessus_ATCC_1997 LDRLTKGDDLDFFIVSSSVSSLFGSPGQSNYATANALLDGLIAQRRAQGL MSMEG_0408|M.smegmatis_MC2_155 LDRLTRDDDLDFFIVSSSVSSLFGSPGQANYATANAMLDGLVAKRRAQGL MAV_1763|M.avium_104 LDHATRTDDLDFFIVSSSVSSLLGSPGQANYSTANAWLDGLVAARQARGL Mvan_1003|M.vanbaalenii_PYR-1 LHRLTRDTELEFFIVYSSGSSVLGSPGQANYATANAVLDGLVAHRKARGL Mb2956|M.bovis_AF2122/97 LHDAFPPGSVDFFYLTASAAGIFGIPGQGSYAAANSYLDALARARRQQGC MLBr_02357|M.leprae_Br4923 LHEAFPPGSVDFFYLTSSAAGIFGIPGQGSYAAANSYLDALARTRRQQGC MUL_2019|M.ulcerans_Agy99 LHRLSLKVPARHFVLFSSISGLIGSRWLAHYTATSGYLDALAYARHALGL Rv0405|M.tuberculosis_H37Rv QRNPLGVALIDTYLPSQIANPSMNEGFSPNDTGKGLSREVIRVARMLNRL TH_4458|M.thermoresistible__bu -------------------------------------------------- MMAR_1180|M.marinum_M LHQLTANTELAAFVLFSSAAGVLGAPGQANYAAANAVLDALARERGPGAT Mflv_0405|M.gilvum_PYR-GCK PATGVNFGPWARGGMASSEAAAANISAQGLIPLEPSA---ALTAMAEVVA MAB_0939|M.abscessus_ATCC_1997 PATGINFGPWGQGGMASSEAATANISAQGLIPLDPSA---ALAALAEVVA MSMEG_0408|M.smegmatis_MC2_155 VATGINFGPWGQGGMASSEAATANITAQGLIPLDPSA---ALHALAEVIA MAV_1763|M.avium_104 PATGVNLGPWAQGGMASSEAARANIGAQGLIPLEPTA---ALAALAEVVA Mvan_1003|M.vanbaalenii_PYR-1 PATGVNWGPWAQGGMATSDAARANLGAQGLIPLEPTA---ALNALGEIVA Mb2956|M.bovis_AF2122/97 HTMSLDWVAWRGLG----LAADAQLVSEELARMGSRD---ITPSEAFTAW MLBr_02357|M.leprae_Br4923 HTMSIDWVAWRGLG----FAANAQIVSDELQRMGSRD---ITPSEAFTAW MUL_2019|M.ulcerans_Agy99 PATTVNWGLWKSLADAE-HDASQVSVGSGLLPMQDEV---AIGTLPLLMN Rv0405|M.tuberculosis_H37Rv TAT---------------RLTAAATYAAIFQAWEPGR---SMAPVLNIVA TH_4458|M.thermoresistible__bu -------------------------------------------------- MMAR_1180|M.marinum_M SLAWGYWQPSSGMTGHLDARDQARLTRSGMVPITTSAGLALFDAALGVQH Mflv_0405|M.gilvum_PYR-GCK NGTAQATVLKANWQRAAKVLGSSRPPILDLVLPSAVGEITGDSELLKQLQ MAB_0939|M.abscessus_ATCC_1997 NGTGQATILKANWQRAAKVLGSSRPPILDLVLPSAVGEVTGDSELLKQLM MSMEG_0408|M.smegmatis_MC2_155 NGSGQATVLKANWQRAAKVLGSARPPILDLVLPSAAGEATGDSELLKQLM MAV_1763|M.avium_104 NGTGQATVIKANWQRAAKLLGGARPPILDLVLPSAVGEASGDSELLKQLQ Mvan_1003|M.vanbaalenii_PYR-1 HGIASAVVLKANWQRAAKLLGATRPPILDHVLPSAVAAGPGDSALLKQLQ Mb2956|M.bovis_AF2122/97 EFVDGYDVAQAVVVPMPAPAGAD-----------GSGA-NAYLLPARNWS MLBr_02357|M.leprae_Br4923 EYVDAYDVAQAVVLPVPRSYGSA-----------GSTAGDSYLVPARNWS MUL_2019|M.ulcerans_Agy99 PAAGVHSVVVEADWPLLAAAYRTRW-SLHIVDDLLRDFAEASTIPARDWS Rv0405|M.tuberculosis_H37Rv KDR----------------------------------------------- TH_4458|M.thermoresistible__bu -------------------------------------------------- MMAR_1180|M.marinum_M PNLIPAPLSTRALAALARESSLPPIFSALISTRPQAAMADSRALGARLAG Mflv_0405|M.gilvum_PYR-GCK EIPVPQRAGFVTEFLQKEVQNFLRLAQPPAATSR-FLDLGTDSLMAIELR MAB_0939|M.abscessus_ATCC_1997 EIPVPQRAGFVTEFLQREVQNFLRLAQPPAATSR-FLDLGTDSLMAIELR MSMEG_0408|M.smegmatis_MC2_155 EIPIPQRAGFVTEFLQREVQNFLRLASPPAASSR-FLDLGTDSLMAIELR MAV_1763|M.avium_104 EIPVAQRAAFITEFLQREVQGFLRLAQPPAATSR-FLDLGTDSLMAVELR Mvan_1003|M.vanbaalenii_PYR-1 DVPEAQRGSFVTEHLQRELQQILGLAQPPAATGR-FLELGMDSLMAVELR Mb2956|M.bovis_AF2122/97 VMAATEVRSELEQGLRRIIAAELRVPEKELDTDRPFAELGLNSLMAMAIR MLBr_02357|M.leprae_Br4923 QMEAAEVRKELESGLRTIIAAELRVAEAELDTDRPFAELGLNSLMAMAIR MUL_2019|M.ulcerans_Agy99 HLSAQEVRTEFEAGLRRIVARELRVSESDLETDRPLAELGLNSLMAMAIR Rv0405|M.tuberculosis_H37Rv ---IATVENLREERINRWRTAAAEAAYSVAEVPG--DHFGMMSTSSEAIA TH_4458|M.thermoresistible__bu -------------------------------------------------- MMAR_1180|M.marinum_M LTPEQQHAMLTKLVLTATAAVLAHPDPAAMDPDQPFKDLGIDSLSALELR Mflv_0405|M.gilvum_PYR-GCK NRLHSQFGGAFTINATAVFDYPTIGGLAEYLVAQLPDAETPQAAP----- MAB_0939|M.abscessus_ATCC_1997 NRLHSQFGGKFTINATAVFDYPTIGGLAEYLVGQLPDADAESAEAPPAVE MSMEG_0408|M.smegmatis_MC2_155 NRLHSQFGGKFTINATAVFDYPTIGGLAEYLVGQLPDAEAPETA------ MAV_1763|M.avium_104 NRLHSQFGGAFTINATAVFDYPTIGGLAEYLAGQLPDAESEPGAAVAANP Mvan_1003|M.vanbaalenii_PYR-1 NRLVGQFGSGFTITATAVFDYPTIGALAEYLAAQTPESTEEGTEMKTADP Mb2956|M.bovis_AF2122/97 REAEQFVG--IELSATMLFNHPTVKSLASYLAKRVAPHDVSQDNQISALS MLBr_02357|M.leprae_Br4923 REAEQFIG--IELSAIMLFNHPTVALLAAYLTKVVAPQHDSQGDEMAALS MUL_2019|M.ulcerans_Agy99 REAEMFVG--IELSATMLFNHPTVASLASYLANRVAPQDNSSNDQMAELS Rv0405|M.tuberculosis_H37Rv TEIHDWISGLVRGPHR---------------------------------- TH_4458|M.thermoresistible__bu -------------------------------------------------- MMAR_1180|M.marinum_M GALSAQSG--VDLPATLIFDHPSPASVAVHLADLLSVAAVPAAAAAQVGK Mflv_0405|M.gilvum_PYR-GCK --QSESEPGPDVTE------------------------------------ MAB_0939|M.abscessus_ATCC_1997 SAEAESGAGPAAASDAVSELKE---------------------------- MSMEG_0408|M.smegmatis_MC2_155 -------------------------------------------------- MAV_1763|M.avium_104 NPGSETGTGEAEPEREAAPEPS---------------------------- Mvan_1003|M.vanbaalenii_PYR-1 DGQPATVGHADVVLQTS--------------------------------- Mb2956|M.bovis_AF2122/97 SSAGSVLDSLFDRIESAPPEAERSV------------------------- MLBr_02357|M.leprae_Br4923 ASAGGVLDSLFDRIESTSTEAEGLV------------------------- MUL_2019|M.ulcerans_Agy99 ASAGSTLDSLFDRIESSSLLPEGPG------------------------- Rv0405|M.tuberculosis_H37Rv -------------------------------------------------- TH_4458|M.thermoresistible__bu -------------------------------------------------- MMAR_1180|M.marinum_M RAAEPADDRLAYLDQAAFLGLRAGYGSLIQMIWIYDRAVDVEGLRRFHRN Mflv_0405|M.gilvum_PYR-GCK -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 -------------------------------------------------- MAV_1763|M.avium_104 -------------------------------------------------- Mvan_1003|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb2956|M.bovis_AF2122/97 -------------------------------------------------- MLBr_02357|M.leprae_Br4923 -------------------------------------------------- MUL_2019|M.ulcerans_Agy99 -------------------------------------------------- Rv0405|M.tuberculosis_H37Rv -------------------------------------------------- TH_4458|M.thermoresistible__bu -------------------------------------------------- MMAR_1180|M.marinum_M LGCGLLGRRIERSPLPFARDRWVSAPVSQQIDFATTPRRRADVGAWADER Mflv_0405|M.gilvum_PYR-GCK -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 -------------------------------------------------- MAV_1763|M.avium_104 -------------------------------------------------- Mvan_1003|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb2956|M.bovis_AF2122/97 -------------------------------------------------- MLBr_02357|M.leprae_Br4923 -------------------------------------------------- MUL_2019|M.ulcerans_Agy99 -------------------------------------------------- Rv0405|M.tuberculosis_H37Rv -------------------------------------------------- TH_4458|M.thermoresistible__bu -------------------------------------------------- MMAR_1180|M.marinum_M ARLPIDPEWGPGWHLGVVGLDDGGTAVSLVASHTIADAIAFGQAVVNAAE Mflv_0405|M.gilvum_PYR-GCK -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 -------------------------------------------------- MAV_1763|M.avium_104 -------------------------------------------------- Mvan_1003|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb2956|M.bovis_AF2122/97 -------------------------------------------------- MLBr_02357|M.leprae_Br4923 -------------------------------------------------- MUL_2019|M.ulcerans_Agy99 -------------------------------------------------- Rv0405|M.tuberculosis_H37Rv -------------------------------------------------- TH_4458|M.thermoresistible__bu -------------------------------------------------- MMAR_1180|M.marinum_M GRTQDLGYPAAGSRILRRALREDLRQTVNELPKIAHAFGGVVRRLRRDRQ Mflv_0405|M.gilvum_PYR-GCK -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 -------------------------------------------------- MAV_1763|M.avium_104 -------------------------------------------------- Mvan_1003|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb2956|M.bovis_AF2122/97 -------------------------------------------------- MLBr_02357|M.leprae_Br4923 -------------------------------------------------- MUL_2019|M.ulcerans_Agy99 -------------------------------------------------- Rv0405|M.tuberculosis_H37Rv -------------------------------------------------- TH_4458|M.thermoresistible__bu -------------------------------------------------- MMAR_1180|M.marinum_M ELQSSIKAAPPPPRMAGGDHSVEVPAVTAYIDLADWDACAKRLGAKSNSL Mflv_0405|M.gilvum_PYR-GCK -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 -------------------------------------------------- MAV_1763|M.avium_104 -------------------------------------------------- Mvan_1003|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb2956|M.bovis_AF2122/97 -------------------------------------------------- MLBr_02357|M.leprae_Br4923 -------------------------------------------------- MUL_2019|M.ulcerans_Agy99 -------------------------------------------------- Rv0405|M.tuberculosis_H37Rv -------------------------------------------------- TH_4458|M.thermoresistible__bu -------------------------------------------------- MMAR_1180|M.marinum_M VGGVACRLAARVGRVQGDGTVTLRIVVSLRTKDDTRGNALTAVDVAVDPA Mflv_0405|M.gilvum_PYR-GCK -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 -------------------------------------------------- MAV_1763|M.avium_104 -------------------------------------------------- Mvan_1003|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb2956|M.bovis_AF2122/97 -------------------------------------------------- MLBr_02357|M.leprae_Br4923 -------------------------------------------------- MUL_2019|M.ulcerans_Agy99 -------------------------------------------------- Rv0405|M.tuberculosis_H37Rv -------------------------------------------------- TH_4458|M.thermoresistible__bu -------------------------------------------------- MMAR_1180|M.marinum_M HAATDLREMHAKITRAILEGMEDLDNEFLAPLPLAAITPRWVARRLVGMA Mflv_0405|M.gilvum_PYR-GCK -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 -------------------------------------------------- MAV_1763|M.avium_104 -------------------------------------------------- Mvan_1003|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb2956|M.bovis_AF2122/97 -------------------------------------------------- MLBr_02357|M.leprae_Br4923 -------------------------------------------------- MUL_2019|M.ulcerans_Agy99 -------------------------------------------------- Rv0405|M.tuberculosis_H37Rv -------------------------------------------------- TH_4458|M.thermoresistible__bu -------------------------------------------------- MMAR_1180|M.marinum_M AGGPTLPVTCSNVGDVPPAANRPDGTDADFAYIRLVEPDIAKSVLEGTGG Mflv_0405|M.gilvum_PYR-GCK -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 -------------------------------------------------- MAV_1763|M.avium_104 -------------------------------------------------- Mvan_1003|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb2956|M.bovis_AF2122/97 -------------------------------------------------- MLBr_02357|M.leprae_Br4923 -------------------------------------------------- MUL_2019|M.ulcerans_Agy99 -------------------------------------------------- Rv0405|M.tuberculosis_H37Rv -------------------------------------------------- TH_4458|M.thermoresistible__bu -------------------------------------------------- MMAR_1180|M.marinum_M RMLLASGRGRGKMCIGISAYLVGHSNTKDELREVVSRTFAEFGLNAEIDC