For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
SLILDRVRELGTQIPDAAALSFVNDRGLVTESMSRVDVVTEMNKVAQFVRQDCGLAPGDRAVLVYPPGLD FVCGLLGCMAAGVIAVPVFPPDPINPQKSGAAFRRVALDCGATAVLTSHHYADARQLEVAAPVGTAFDED WPNALPWHVTSRGASGRGKSAPRAVSEAISEWAPSPQTPALLQYTSGSTSDPKGVVITHGNVVHQAEFNR RFIGLGPGHRAVFWVPPYHDFGLISGILSALAGNFDLTMMSPMSFIQRPALWFEVMDRVRATVTVAPNFG FELAMRKTTAEQRAGWDLSPLQVIVSAAEPVREDTTRRFFEAFAASGIRREAFCPCYGLAEHTVGITVSG RSSLRVDRSQLEARQLAVPSDAPDAQVLMGCGQPTDDVDVRIVDPELCVPLGDGQVGEIWADSPSKAAGY WGLSAKSRATFQAALAGVEGGRGYLRTGDLGFLHDGELYVCGRIKDLLILAGRNIYPQDIEDSLRDCHPA IRPGGFAAFAVVDGNSETLAVLVEVRTDGSPDLLAGVVAAIRAAVLKDHQLRCGVVVLGPPGSVSKTTSG KVQRSRCRARFLDGTLQAQALLVDRRTDDEPVGAAPTTEQLLSVVCGQAAEVLGIGAASVDIDRSLGDQG LNSIGVTELASRLTQVLGQDVQPVDIFNHPTVGDLVQILSPGEKTRHQRGVRERLGHHAASGAGAVALPA DPVAIVGIGCRFPGGVDSADSLWDMVVSARDVISDFPGDRGWDAGRLFDPDPDALGKTYCAVGGFLEDAA GFDAGFFGIAPREALAMDPQQRVLLEVSWEALEDAGIDPKALRGSATGVFVGTWAQPYGDGGSDSADGYA MTGTATSVASGRVAYVLGLEGPAVSVDTACSSSLVAVHQAVQSLRLGECDLALAGGVTVMATPSVFVGFS RQRGLAPDGRCKAFAEAADGVGWGEGAGVLVLQRLSDARRQGRVVLGVVRGSAVNQDGASHGLTAPNGPA QQRVIRAALAGAGLGPADVDVVEAHGTGTRLGDPIEAQALLAVYGQDREPGRPLWVGSIKSNMGHAQAAA GVAGVIKMVQAMRHGLLPETLHVDEPSGQVDWSAGAVEVLSRARSWLGVPGRPRRAGVSSFGISGTNAHV IVEQALPEVAESGGVSGVCGQGVGSVESVVRASVVPWVLSAQSRQALVAQASRLLGRVGGDDGLDPVDVG LSLAQRCVFEHRAVVVGRDREALLAGLTGLARGGPGAGVVVGQAAAVGKTVLVFPGQGAQWTGMGRGLHG QFPAFARAFDAAVDELDQHLPMPLREVMWGTDKGLLDSTEFAQPALFALEVGLWALLEHWGIRPDFVLGH SVGELSAAHVAGVLSLADAAMLVAARGRLMQGLPAGGVMVALGVGEQEVDPLLAESAHPVSIAAINAPEQ VVISGAQAAVMTIADQLAARGHRVQQLAVSHAFHSPLMEPIVEEFAEIAGRVTVEAPRIGVISNLTGELA GPGYGSKAYWREHIRRPVRFSDSVACARAQGATHFVEAGPGAGLTAAIEQSLGSVAATVVAVLGKQRPEP DSLLDAAAQLFASGARLDWPAVFLGWGGRRVSLPTYAFMRQRFWLTPHLAGSVGAAELGSGNPRHPLLDA VVEHPDSGEVILAGRLSRRAQPWLADHVIGGLVLLPGTGFVELVIRAGDQLGCAAIDELTLTNPLIVPDG SEVQVQVVVGAAERSGRRTVSVYSRADHIGAAWVQHAEGALGVDPMPASGDFSVWPPSGAEAVRVSDAYE RLAQLGYRYGPAFRGIEAIWRRGTEVYAEVAIPADAELGINGYGIHPVLLDAVLQAAAVAVDSGDTRLPY SWRGISLHAAAAKRIRARIAPVGEVGYAVECADVAGLPVLTMGSLVTRPVSAEQLHAGAATAIGRPAQGL LELAWSPISPAHGALDGGGHQTVLSWADFTAGAAAAADGVGGRAVAVVWESRTAETDVVGSVYARIHAAL SVLQHWLAQDQLASLVVVTHGAVGLPGEAITDLAGSAVWGLARSAQAESPGRIVLVDIDTPNTPDLGVLL AGREPQLVVRGDSVFCARLRPVEAPLEVPVGQSAWQLSTGGGGTLADIVVQPCPPAQAPLEPGQVRVAVA AAGVNFRDVLMALGMYPGAQPVLGGEGSGVVLEVGPQVSGVGVGDAVMGLIAGVGPLAVVDARLLVRVPS GWSLAEAAGVPVAFLTAWYGLADLAGVRAGESVLVHAGTGGVGMAAVQLARLWGAKVFVTASRGKWDTLR SMGFDDSRIGDSRSLEFAEKFFAATRGRGVDVVLNSLAGEFVDASLRLLAPGGRFIEMGKTDIRDPQQIA VEYPGVIYEAFDLIEAGPARIQPMLGQLHTLFEASALESLPTRTWDARCAPAAYRFVSQARQIGKVVLTM PTQISDAVAAGTVLITGGTGMVASVLARHLVSSYGVKHVVLASRRADATAGVAELVADLAAAGAAVAVVA CDVADRAAVTRLLDHVSTCHPPLTGVIHAAGTLDDAVIASLTPDRVDAVLRAKVDGAWNLHEATRHLGLS MFVLCSSIAATVGSSGQANYAAGNAFLDGLAAYRRAGGLPGMSLGWGLWEQSSTMTAHLSDRDMARIRRI GLAAISPEQAMQLFDAALAVGQPTVLAAHLDHAVLANHTLSSTLPPLFSTLIKRPLRRLVDNDTPSSTAG FAQRLYGLKPEKQQDLLVDLVCTQAAAVLGHPSATDLNPASTFQNMGFDSLTAVELRNRLKTVTGLGLSP TLVFDHPTPTALAGLIAELIGIAAKGLSPLEEALNNVEETLPAIEAGDKHRVADRLRALLSTITDEEHRL DERIQAASTLDEVLLLVDSELANLEKGPGL*
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. marinum M | MMAR_3099 | - | - | 100% (2831) | polyketide synthase and peptide synthetase |
M. marinum M | MMAR_3098 | - | 0.0 | 66.32% (2102) | polyketide synthase PKS |
M. marinum M | MMAR_1762 | pks15/1 | 0.0 | 63.09% (2081) | polyketide synthase Pks15/1 |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb2971c | pks1 | 0.0 | 65.74% (2058) | polyketide synthase PKS1 |
M. gilvum PYR-GCK | Mflv_0405 | - | 0.0 | 37.36% (2262) | beta-ketoacyl synthase |
M. tuberculosis H37Rv | Rv2048c | pks12 | 0.0 | 55.72% (2272) | polyketide synthase pks12 |
M. leprae Br4923 | MLBr_00135 | - | 0.0 | 64.13% (2060) | putative polyketide synthase |
M. abscessus ATCC 19977 | MAB_0939 | - | 0.0 | 36.64% (2276) | polyketide synthase |
M. avium 104 | MAV_3108 | - | 0.0 | 59.09% (2112) | erythronolide synthase, modules 3 and 4 |
M. smegmatis MC2 155 | MSMEG_0408 | - | 0.0 | 36.89% (2247) | type I modular polyketide synthase |
M. thermoresistible (build 8) | TH_4458 | - | 0.0 | 39.74% (1364) | PUTATIVE putative Fatty acyl-AMP ligase FadD28_1 and polyketide |
M. ulcerans Agy99 | MUL_2005 | pks15/1 | 0.0 | 62.81% (2081) | polyketide synthase Pks15/1 |
M. vanbaalenii PYR-1 | Mvan_1003 | - | 0.0 | 36.42% (2474) | beta-ketoacyl synthase |
CLUSTAL 2.0.9 multiple sequence alignment Mflv_0405|M.gilvum_PYR-GCK ----------------------MGSAAHQGE-SAHRFAIVGYAGRFPG-A MAB_0939|M.abscessus_ATCC_1997 ----------------------MDSAENPIE-STPRFAIIGYAARFPG-A MSMEG_0408|M.smegmatis_MC2_155 ----------------------MVSAEHPIE-PTPSFAIIGYAARFPG-A Mvan_1003|M.vanbaalenii_PYR-1 --------MTDLQKRALQAIEVLRARVRELEGAGDGYAIVGYALRFPG-A Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MMAR_3099|M.marinum_M -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv MVDQLQHATEALRKALVQVERLKRTNRALLERSSEPIAIVGMSCRFPGGV TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK RDAESFWELLADGRDAISEVPEDR-WDVEAFFDPDPSTPGKVVTRRAGFV MAB_0939|M.abscessus_ATCC_1997 ADAEEFWDVLREGRDAISEVPADR-WDAEEFFDPEPGAPGKVVTRRAGFV MSMEG_0408|M.smegmatis_MC2_155 ASAEEYWALLRDGREAISDVPKDR-WDIEEFFDPDPSTPGKVVTRRAGFV Mvan_1003|M.vanbaalenii_PYR-1 ADADEFWDVLRGGRDAISEVPQDR-WDADEFFDADPEAAGKMVTRRAGFV Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MMAR_3099|M.marinum_M -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv DSPEGLWQMVADARDVMSEFPTDRGWDLAGLFDPDPDVRHKSYARTGGFV TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK DDVSGFDAPFFGMSTREVRLMDPQHRLLLETAWRAIEHSGTAPSELANTN MAB_0939|M.abscessus_ATCC_1997 EDVTGFDAPFFGMSTREVRLMDPQHRLLLETAWRAVEHSGIAPTDLAETN MSMEG_0408|M.smegmatis_MC2_155 DDVTGFDAPFFGMSAREVRLMDPQHRILMETAWRAVEHSGIAPTSLANSN Mvan_1003|M.vanbaalenii_PYR-1 EDVAGFDAPFFGVSAREAMFMDPQHRLLLETAWRAVEHSGTAPSALAGTR Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MMAR_3099|M.marinum_M -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv DGVADFDPAFFGISPSEALAMDPQHRMLLELSWEALERAGIDPTGLRGSA TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK TGVFVGLATHDYLGMASDELSYPEIEAYMAIGTSNAAAAGRISYRLGLQG MAB_0939|M.abscessus_ATCC_1997 SGVFVGLATHDYLGMASDELTFPEIEAYMAIGTSNAAAAGRISYRLGLQG MSMEG_0408|M.smegmatis_MC2_155 TGVFVGLATHDYLGMASDELTYPEIEAYMAIGTSNAAAAGRISYRLGLQG Mvan_1003|M.vanbaalenii_PYR-1 TGVFMGLSTHDYLGMLTDNLTHDAIEAYLGTGTSPAAAIGRISYRLGLQG Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MMAR_3099|M.marinum_M -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv TGVFAGLIVGGYG------MLAEEIEGYRLTGMTSSVASGRVAYVLGLEG TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK PAVAVDTACSSSLVAIHQACQALRLGECDLALAGGANVILTPATMITFSN MAB_0939|M.abscessus_ATCC_1997 PSVAVDTACSSSLVAIHQACQALQLGECDLALAGGANVLLTPATMITFSH MSMEG_0408|M.smegmatis_MC2_155 PAVAVDTACSSSLVAIHQACQALRLNECDLALAGGANVLLTPATMITFSN Mvan_1003|M.vanbaalenii_PYR-1 PAVAVDTACSSSLVAVHQACQALRLAECDVALAGGVNVLLSPATMINFSR Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MMAR_3099|M.marinum_M -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv PAVSVDTACSSSLVALHMAVGSLRSGECDLALAGGVTVNATPTVFVEFSR TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK AHMLAPDGRCKTFDAAADGYVRGEGCGVIVIKRLEDAVRDGDRIRAVIRG MAB_0939|M.abscessus_ATCC_1997 AHMLAPDGKCKTFDAAADGYVRGEGSGVIVIKRLEDAIRDGDRIRAVIRG MSMEG_0408|M.smegmatis_MC2_155 AHMLAPDGRCKTFDAAADGYVRGEGCGVVVVKRLEDAVRDGDRIRAVIRG Mvan_1003|M.vanbaalenii_PYR-1 ARMLAPDGRCKTFDATADGYVRGEGCGVVVVKRLADAIRHGDRIRAVIRG Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MMAR_3099|M.marinum_M -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv HRGLAPDGRCKPYAGRADGVGWSEGGGMLVLQRLSDARRLGHPVLAVVVG TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK SAINQDGASGGLTVPNGVAQQRVIGDALSRAGLAPGDVDYLEAHGTGTSL MAB_0939|M.abscessus_ATCC_1997 SAINQDGASGGLTVPNGVAQQRVIADALKRAGVAPSEVGYLEAHGTGTSL MSMEG_0408|M.smegmatis_MC2_155 SAINQDGASGGLTVPNGVAQQRVIADALKRAGLRPADVGYLEAHGTGTSL Mvan_1003|M.vanbaalenii_PYR-1 SAVNQDGASGGLTVPNGAAQQRVIADALTNAGLTAADVDYLEAHGTGTPL Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MMAR_3099|M.marinum_M -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv SAVNQDGASNGLTAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGTGTTL TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK GDPIEAQAAGAALGPGR-EPQRPLLIGSAKTNIGHLEAAAGIAGVIKVVL MAB_0939|M.abscessus_ATCC_1997 GDPIEAQAAGAAYGIGR-ETNDPLLIGSAKTNIGHLEAAAGIAGVIKVIL MSMEG_0408|M.smegmatis_MC2_155 GDPIEAQAAGEVLGAGR-APEEPLLIGSAKTNIGHLEAAAGIAGVIKVVM Mvan_1003|M.vanbaalenii_PYR-1 GDPIEVQAAGAVLGVGR-EPDRPLLIGSVKTNIGHLEAASGIAGLLKVIL Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MMAR_3099|M.marinum_M -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv GDPIEAQALLATYGQDRGEPGEPLWLGSVKSNMGHTQAAAGVAGVIKMVL TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK SLEHETLPKHLNFENPSPHIPWDRLPVEVVKESIPWRRGQRGGRPRIAGV MAB_0939|M.abscessus_ATCC_1997 SLENELLPQHRNFQNPSPHIPWDRLPVEVVREARPWGR---NGRPRIAGV MSMEG_0408|M.smegmatis_MC2_155 ALENETLPKHLNFETPSPHIPWERLPIEVVRETVPWQR---NGKPRIAGV Mvan_1003|M.vanbaalenii_PYR-1 SLEHQVLPKHLNFRSPSPHIPWNRLPVRIVDDPVPWTR---SGRSRVAGI Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MMAR_3099|M.marinum_M -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv AMRHELLPATLHVDVPSPHVDWSAGAVELLTAPRVWPAG---ARTRRAGV TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK SSFGFAGTNAHVILEEAPLAAEPAQES---VDDGRFTLLPLSARTPAALM MAB_0939|M.abscessus_ATCC_1997 SSFGFAGTNAHVILEEAPVVSRDAVEPPAPAGGRKFSILPLSARTPAALA MSMEG_0408|M.smegmatis_MC2_155 SSFGFAGTNAHVILEEAPAVGTPATTEP-VEDPRRYSVLPLSARTPEALV Mvan_1003|M.vanbaalenii_PYR-1 SSFGFSGTNAHVLVEEAPRADRAGAAPQ-PAAPGGFGMLPLSARTPDALA Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MMAR_3099|M.marinum_M -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv SSFGISGTNAHVIIEAVPVVPRREAGWA-----GPVVPWVVSAKSESALR TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK AVADRYRDWLVANPDATLADLCFTAGTARSHLEHRAALVVNTREAALDLL MAB_0939|M.abscessus_ATCC_1997 QLADKYRAWLNAHPEAALADLCFTAGVGRAHLEHRAALVVNTREAAVELL MSMEG_0408|M.smegmatis_MC2_155 RLAGEYRDWLRAHPQARLADVSHTAGTARAHLEQRAALVVNSRESAIELL Mvan_1003|M.vanbaalenii_PYR-1 ATAHRLRTWLAANPDASWPDLCFTAAVGRSHLRHRAALVVDSRSSVEELL Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MMAR_3099|M.marinum_M -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv GQAARLAAYVRGDDGLDVADVGWSL-AGRSVFEHRAVVVGGDRDRLLAGL TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK GALADDRPAPGLVRGESHDTPKTAWLFTGQGSQYPGMSRELFDTEPLFAE MAB_0939|M.abscessus_ATCC_1997 SAVADDRPAPGLGRGESHDTPKTAWLFTGQGSQYPGMARELFETEPVFAD MSMEG_0408|M.smegmatis_MC2_155 GALADDRPAPGLVRGESHEAPKTAWLFTGQGSQYPGMARELFDTEPVFAE Mvan_1003|M.vanbaalenii_PYR-1 GALAEDRPGPGLARGECGDPPKTAWLFTGQGSQYPGMGRELFDTEPVYRE Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MMAR_3099|M.marinum_M -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv DELAGDQLGGSVVRGTATAAGKTVFVFPGQGSQWLGMGIELLDTAPAFAQ TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK TLRECAAAVDGMLEKPLLDVIFDTDGVLDTDSNETLRHTSYAQPALFAVE MAB_0939|M.abscessus_ATCC_1997 TLNRCAAAVADVLEKPLLDVIFDVD---GPEAEETLRQTSYAQPALFAVE MSMEG_0408|M.smegmatis_MC2_155 TVRKCAEAVADILEKPLLDVIFDAD-ELDGDTESPLRHTTYAQPALFAVE Mvan_1003|M.vanbaalenii_PYR-1 VMTRCAEAVADVLERPLLDVVFDAD------GGEALRHTSYAQPALYAVE Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MMAR_3099|M.marinum_M -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv QIDACAEAFAEFVDWSLVDVLRGAP------GAPGLDRVDVVQPVLFAVM TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK MGLARLWQSWGFEPDVVLGHSVGQYAAACVAGVLSLRDGARLMAERGRLF MAB_0939|M.abscessus_ATCC_1997 MGLARLWQSWGFEPDVVLGHSVGQYSAACVAEVFSLEDGARLIAERGRLF MSMEG_0408|M.smegmatis_MC2_155 LGLARLWQSWGFEPDVVVGHSVGQYSAACVAGVFDVEDGARLIAERGRLF Mvan_1003|M.vanbaalenii_PYR-1 MGLARLWQSWGIEPDVVLGHSVGQYAAACVAGVMGLEDGAVLLAERGRLF Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MMAR_3099|M.marinum_M -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv VSLAELWKSVAVHPDAVIGHSQGEIAAAYVAGALSLRDAARVVTLRSKLL TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK GSLPSGGRMAAVFAAAERVEALTDEYPALS--VAAYNGANTVLSGPATDL MAB_0939|M.abscessus_ATCC_1997 SSLPAGGRMAAVFTDAERAERLTDEFPSLS--VAAYNGANTVLSGPAQDL MSMEG_0408|M.smegmatis_MC2_155 GSLPAGGRMAAVFTAPERAERLTDEYPSLS--VAAYNGANTVLSGPAKDL Mvan_1003|M.vanbaalenii_PYR-1 GSLPEGGRMAAVFAPADRVESCTVDSPLLS--VAAYNGDNTVLSGPAGDL Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MMAR_3099|M.marinum_M -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv AGLAGPGGMVSIACGADQARDLLAPFGDRVSIAVVNGPSAVVVSGEVGAL TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK ERAVAGLVADGVRCDWLETSHAFHSALLDPILDDFESYARGITFTAPQRI MAB_0939|M.abscessus_ATCC_1997 EKAIAALVADGVRCDFLETSHAFHSALLDPILDEFEAYANQFNYKTPQRI MSMEG_0408|M.smegmatis_MC2_155 ESAVATLVADGVRCDWLDTSHAFHSALLDPILDDFESFAQKLEYREPQRI Mvan_1003|M.vanbaalenii_PYR-1 ERAVAGFSAAGVRCDWLDTSHAFHSALLDPVLEEFESCADRFEFGTPQRT Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MMAR_3099|M.marinum_M -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv EELIAVCSTKELRTRRIEVDYASHSVEVEAIRGPLAEALSGIEPRSTRTV TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK LIDNRTGAALGRSVTLDAAYWRRHARQPVEFAKSVH-------------- MAB_0939|M.abscessus_ATCC_1997 LIDNRTGTALGRSVKLDGAYWRRHARQPVEFAKSVR-------------- MSMEG_0408|M.smegmatis_MC2_155 LIDNRTGSALGRSTRLDGAYWRRHARQPVEFAKSVR-------------- Mvan_1003|M.vanbaalenii_PYR-1 LVCNRSGEVLSRHARLDGQYWRRHARQPVRFAESVR-------------- Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MMAR_3099|M.marinum_M -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv FFSTVTGNRL-DTAGLDADYWYRNVRQTVLFDQAVRNACEQGYRTFIESS TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_1003|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MMAR_3099|M.marinum_M -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv PHPALITGVEETFAACTDGDSEAIVVPTLGRGDGGLHRFLLSAASAFVAG TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_1003|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MMAR_3099|M.marinum_M -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv VAVNWRGTLDGAGYVELPTYAFDKRRFWLSAEGSGADVSGLGLGASEHPL TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_1003|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MMAR_3099|M.marinum_M -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv LGAVVDLPASGGVVLTGRLSPNVQPWLADHAVSDVVLFPGTGFVELAIRA TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_1003|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MMAR_3099|M.marinum_M -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv GDEVGCSVLDELTLAAPLLLPATGSVAVQVVVDAGRDSNSRGVSIFSRAD TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_1003|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MMAR_3099|M.marinum_M -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv AQAGWLLHAEGILRPGSVEPGADLSVWPPAGAVTVDVADGYERLATRGYR TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_1003|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MMAR_3099|M.marinum_M -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv YGPAFRGLTAMWARGEEIFAEVRLPEAAGGVGGFGVHPALLDAVLHAVVI TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_1003|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MMAR_3099|M.marinum_M -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv AGDPDELALPFAWQGVSLHATGASAVRARIAPAGPSAVSVELADGLGLPV TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK -------------------------------------------------- MAB_0939|M.abscessus_ATCC_1997 -------------------------------------------------- MSMEG_0408|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_1003|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MMAR_3099|M.marinum_M -------------------------------------------------- MAV_3108|M.avium_104 -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv LSVASMVARPVTERQLLAAVSGSGPDRLFEVIWSPASAATSPGPTPAYQI TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK -TLADMNCKLLVEIGPRPVLTAAALSAWPDPATSPRVIASLRRTTADQRQ MAB_0939|M.abscessus_ATCC_1997 -TLADMNCKVLLEIGPQPVLTAAALRAWPDPATAPRAIASLRRNTADHRQ MSMEG_0408|M.smegmatis_MC2_155 -TLADMNCRVLLEIGPRPVLTATALAAWPDPATTPQVLASLRPTTADHRQ Mvan_1003|M.vanbaalenii_PYR-1 -TLADLGCRLLMEIGPQPVLTAAAMRTWPGTVTAPRVAASMRRKGSDRRQ Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MMAR_3099|M.marinum_M -MSLILDRVRELGTQIPDAAALSFVNDRGLVTES------------MSRV MAV_3108|M.avium_104 -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv FESVAADQDPVAGSYVRSHQALAAVQSWLTDHESGVLVVATRGAMALPRE TH_4458|M.thermoresistible__bu -------------------LLSLLRQRSERYGDKIAFDYCTGEQEHSRLT Mflv_0405|M.gilvum_PYR-GCK ITEAVADAYVLGHLPRFAAFRRDGARVLDLPTYPFEH---RQYWFSDSRE MAB_0939|M.abscessus_ATCC_1997 ITEAAADAYVLGHLPDFGAFQHAPARKLDLPTYPFER---RQYWFSDKRD MSMEG_0408|M.smegmatis_MC2_155 ITEAVAAAYAAGHLPDFRAFRQPDARKLDLPTYPFEH---RQFWFSDNRA Mvan_1003|M.vanbaalenii_PYR-1 ITEALAQAYVAGHRPETAARQHGRGRLLDLPTYPFQH---RAYWFP---- Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MMAR_3099|M.marinum_M DVVTEMNKVAQFVRQDCGLAPGDRAVLVYPPGLDFVCGLLGCMAAG---- MAV_3108|M.avium_104 -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv DVADLAGAAVWGLVRSAQTEHPGRIVLVDSDAATDDAAIAMALATGEPQV TH_4458|M.thermoresistible__bu YQELDIRARAIAAHLQDQGVAGERVLVLCPSGLDFITAMFGCFYVG---- Mflv_0405|M.gilvum_PYR-GCK ---PVAAAPQR---GARTETVRLLEDGRIEELAALLGGTVDDPFTFDVLN MAB_0939|M.abscessus_ATCC_1997 GDNRDAGNRQQNNGGPRTEAVRLLEDGKIEELANLLGGVDGDQQTLNVLT MSMEG_0408|M.smegmatis_MC2_155 IDRDTQTASAGSVTPHRTQAVRLLEDGQIEELAALIDGETVDEQTLRVLN Mvan_1003|M.vanbaalenii_PYR-1 ----QGQARTAPTDPVHTETVRFLDEERIDELAALLDGPTGSAQTVDVLS Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MMAR_3099|M.marinum_M ---------------VIAVPVFPPDPINPQKSGAAFRRVALDCGATAVLT MAV_3108|M.avium_104 -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv VLRGGQVYTARVRGSRAADAILVPPGDGPWRLGLGSAGTFENLRLEPVPN TH_4458|M.thermoresistible__bu ------------------AVAVPVHPPVHNRLLSRVASIVADVRATSVLT Mflv_0405|M.gilvum_PYR-GCK RLAAQHNQQRSTESIADDRYQIRWETAAEPPVGADAADGITWLLVGDDTD MAB_0939|M.abscessus_ATCC_1997 KLAAQHNLQRTTQTIADDRYQFRWEKSPTPLSGSQAAGGVTWLLVADAAG MSMEG_0408|M.smegmatis_MC2_155 KLAARHNQQRSTHVDPDARYEIRWDAIASAAASTGAAA--DWILVGDDTA Mvan_1003|M.vanbaalenii_PYR-1 KLAARHRQQRGAQSIADARYQIRWEKSEAPGAARPTTEATTWLLVTHDSR Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MMAR_3099|M.marinum_M SHHYADARQLEVAAPVGTAFDEDWPNALPWHVTSRGASGRGKSAPRAVSE MAV_3108|M.avium_104 -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv ADAPLGPGQVRVAMRAIAANFRDIMITLGMFTHDALLGGEGAGVVVEVGP TH_4458|M.thermoresistible__bu TAATRADLKEILDGLHDG------DPLRWLAVDTIEADDETSWTPTTVDT Mflv_0405|M.gilvum_PYR-GCK ATRPLVDVLAARGHRYRILGLPKSG------------------------- MAB_0939|M.abscessus_ATCC_1997 AAQPLLDVLTARGQQHRVLALPVSD------------------------- MSMEG_0408|M.smegmatis_MC2_155 AVLEFADALTAGGHRHQIVALPGSD------------------------- Mvan_1003|M.vanbaalenii_PYR-1 AAQPIAEVLERRGHPYHIVGLPGSD------------------------- Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MMAR_3099|M.marinum_M AISEWAPSPQTPALLQYTSGSTSDPKGVVITHG----------------- MAV_3108|M.avium_104 -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv GVTEFSVGDSVFGFFPDGSGTLVAGDVRLLLPMPADWSYAEAAAISAVFT TH_4458|M.thermoresistible__bu DSVAFVQYTSGSTSTPKGVVLTHHN------------------------- Mflv_0405|M.gilvum_PYR-GCK ---------AEEHELADTLRDAAADATDLRIVHVAALDAAESDTSMKSLL MAB_0939|M.abscessus_ATCC_1997 ---------ADEAELVEALRSAADEDSALRIVHVAALAGQGS-SSAQSLL MSMEG_0408|M.smegmatis_MC2_155 ---------ADEAQLVDTLRAASAG--ELYVVHIAAGDGAAA--PMRDLL Mvan_1003|M.vanbaalenii_PYR-1 ---------ADAAPAEEALRATVSQ-PRPHILYLAALEEPGG-SAAETLG Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MMAR_3099|M.marinum_M -------NVVHQAEFNRRFIGLGPGHRAVFWVPPYHDFGLISGILSALAG MAV_3108|M.avium_104 -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv TAYYAFIHLADVQPGQRVLIHAGTGGVGMAAVQLARHLGLEVFATASKGK TH_4458|M.thermoresistible__bu --------LLANLESISRDAGQGDEARVVSWLPLHHDMGLIGGIFGVVHF Mflv_0405|M.gilvum_PYR-GCK RMQHRVLGGTRRLFGAAVAAQLRSP------------------------M MAB_0939|M.abscessus_ATCC_1997 RIQHQVLGGTRRLFRAAAAAELRAP------------------------I MSMEG_0408|M.smegmatis_MC2_155 RVQHRTLGGLRRLFRAANDAELRSP------------------------I Mvan_1003|M.vanbaalenii_PYR-1 WMQHRVLAAARRLFQLAATAGARAP------------------------I Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MMAR_3099|M.marinum_M NFDLTMMSPMSFIQRPALWFEVMDRVRATVT------------------- MAV_3108|M.avium_104 -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv WDTLRAMGFDDDHISDSRSLEFEDKFRAATGGRGFDVVLDSLAGEFVDAS TH_4458|M.thermoresistible__bu GGTAYLMPPSSFIQRPMSWLEAISWHG---------------------AN Mflv_0405|M.gilvum_PYR-GCK WLVTRGAQHVTDTDVVAPDQTCLWGFGRAASLEHPQIWGGLADLGGGTSD MAB_0939|M.abscessus_ATCC_1997 WIVTRGAQHVIEGDTVAPEQSALWGFGRAAALELPQVWGGLADLSDAGTD MSMEG_0408|M.smegmatis_MC2_155 WLVTRDGQRVTDTDTVVPEQSCLWGFGRAAALELPHIWGGLADLSGADT- Mvan_1003|M.vanbaalenii_PYR-1 WLITAGAQRITGDETVEPAQTSLWGFGRAAALEQPELWGGLADVTTGDAE Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MMAR_3099|M.marinum_M --VAPNFGFELAMRKTTAEQRAGWDLSPLQVIVSAAEPVREDTTRRFFEA MAV_3108|M.avium_104 -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv LRLVAPGGVFLEMGKTDIRDPGVIAQQYPGVRYRAFDLFEPGRPRMHQYM TH_4458|M.thermoresistible__bu ISVGPNFGYQLCVERSTPEERATLDLSTWVRAYCGAEPVRAATMRRFTEA Mflv_0405|M.gilvum_PYR-GCK EWSRLLNRIAATHDPAVMEDQVAVRGSTSYVPRLVHRDT----LPSGKPL MAB_0939|M.abscessus_ATCC_1997 EWAQFIGRVSVSGEASTREDQLALRGQAVHVPRLVRREE----LPSGKPL MSMEG_0408|M.smegmatis_MC2_155 EWPRLIARITSPRDG---EDQIALRGDAVYAPRLVRRTG----EPSDTPL Mvan_1003|M.vanbaalenii_PYR-1 EWSALIDHIVAAPTS---EDQIAVRGREIHVARLTRCAE----KANAAAL Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MMAR_3099|M.marinum_M FAASGIRREAFCPCYGLAEHTVGITVSGRSSLRVDRSQL----EARQLAV MAV_3108|M.avium_104 -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv LELATLFGDGVLRPLPVTTFDVRRAPAALRYLSQARHTG----KVVMLMP TH_4458|M.thermoresistible__bu FAPAGFRADAFHPVYGLAEATLFVSGRPENVLPTVRSLDNAALREHRVVP Mflv_0405|M.gilvum_PYR-GCK HLRADATYLVTGGLGSLGLEIAGYLAA-NGAGHLVLTSRRTPDEAAASRI MAB_0939|M.abscessus_ATCC_1997 EVRSDATYLVTGGLGSIGLEIAGYLAG-RGAKHLVLTSRREPGEAARQRI MSMEG_0408|M.smegmatis_MC2_155 PVREDRTYLVTGGLGAIGLEVAGYLAS-HGAGHVVLTSRREPGDDARRRL Mvan_1003|M.vanbaalenii_PYR-1 ELRREATYLVTGGLGALGLEVAEFLAS-HGAGHLVLTGRRSASDTVRQRI Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MMAR_3099|M.marinum_M PSDAPDAQVLMG-CGQPTDDVDVRIVDPELCVPLGDGQVGEIWADSPSKA MAV_3108|M.avium_104 -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv GSWAAGTVLITGGTGMAGSAVARHVVARHGVRNLVLVSRRGPDAPGAAEL TH_4458|M.thermoresistible__bu AAADDANAAAVVGCGPAAYGEEIVIVDPATRREFPPDVVGEIWVAGENVA Mflv_0405|M.gilvum_PYR-GCK EALRERHGCEVRVVTADVADAHAVARLLATVQAEMPPLAGIVHAAGEIGT MAB_0939|M.abscessus_ATCC_1997 DALAA-QGCEVRAVTADVADGHDVARLLAGIQAELPPLAGIVHAAGEIGT MSMEG_0408|M.smegmatis_MC2_155 DGLREQYACDVRVITADVADAHDVARLMTTVAAELPPLAGIVHAAGEIGT Mvan_1003|M.vanbaalenii_PYR-1 DAMRERFDCQVLVATADVADRDDVARLFSTMRSELPPLAGIVHAAGEIGT Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MMAR_3099|M.marinum_M AGYWGLSAKSRATFQAALAGVEGGRGYLRTGDLGFL-HDGELYVCGRIKD MAV_3108|M.avium_104 -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv VAELAAAGAQVQVVACDAADRAALAKVIADIPVQHP-LSGVIHTAGALDD TH_4458|M.thermoresistible__bu QGYLGKPSESAETFAAHLADSGRGPFLRTG-------DYGFLLDGELFVT Mflv_0405|M.gilvum_PYR-GCK TPLADLDDAEVDRVFAGKVWGAWHLSEATSDLQ--LDFFISTSSIASVWG MAB_0939|M.abscessus_ATCC_1997 TPLSDLEDAEVDRVFAGKVWGAWHLSEAAAGLK--LDFFINTSSIAAVWG MSMEG_0408|M.smegmatis_MC2_155 TPLSGLDDAEVDRVFAGKVWGAWHLSEALTDLRTDLDFFVSTSSIASVWG Mvan_1003|M.vanbaalenii_PYR-1 SPLRTLDDAEMDRVFAGKVWGAVYLCEEVADMG--LDFFLATSSIASVWG Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MMAR_3099|M.marinum_M LLILAGR----NIYPQDIEDSLRDCHPAIRPGG--FAAFAVVDGNSETLA MAV_3108|M.avium_104 -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv AVVMSLTPDRVDVVLRSKVDAAWHLHELTRDLD--VSAFVMFSSMAGLVG TH_4458|M.thermoresistible__bu GRLKDLIIIRGRNYHPNDIEATVQEVHPALMSGRGAAFAVSPDPSGTEQL Mflv_0405|M.gilvum_PYR-GCK GFGQAAYGAANAFLDGLAWRLREQGVAGVSVNFGPWSAGMADAQSRARLE MAB_0939|M.abscessus_ATCC_1997 GYGQTAYSAANAFLDGLAWRLREQGIAGTSVNFGPWSAGMADAESRARLE MSMEG_0408|M.smegmatis_MC2_155 GFGQTAYGAANAFLDGLAWRLRERGVTAVSVNFGPWAAGMADAESRARLE Mvan_1003|M.vanbaalenii_PYR-1 SHGQTAYGAANAFLDGLADSLRARGIPGISVNFGPWAAGMADAKAREQLS Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MMAR_3099|M.marinum_M VLVEVRTDGSPDLLAGVVAAIRAAVLKDHQLRCGVVVLGPPGSVSKTTSG MAV_3108|M.avium_104 -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv SSGQANYAAANSFLDALAAHRRAHGLPAISLGWGLWDQASAMTGGLDAAD TH_4458|M.thermoresistible__bu VIVQEVDRGRLGEVDTDELIAAIRTAVTSQHDIGVHTVVLVDPLRIPTTS Mflv_0405|M.gilvum_PYR-GCK QRGIKTLSPADALAGLSDAVISAAP---HPVVARVDWSRFLPLYQQAGRR MAB_0939|M.abscessus_ATCC_1997 QRGIKTLSPTDALAGLADVVAASGSNAVQGVIARIDWARFLPLYQQAGKR MSMEG_0408|M.smegmatis_MC2_155 QRGVRTLSPAEALAGMADVVAGPVQ----GVVAKIDWSRFLPLYQQAGRR Mvan_1003|M.vanbaalenii_PYR-1 RRGVKTLAPADALAGMADVIAASTA---HAVVARIDWATFLPVYQLQRRR Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MMAR_3099|M.marinum_M KVQRSRC-------------------------------------RARFLD MAV_3108|M.avium_104 -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv LARLGREGVLALSTAEALELFDTAMIVDEPFLAPARIDLTALRAHAVAVP TH_4458|M.thermoresistible__bu SGKIRRRTCRQRFLDGELDAFAEWR--------------------LATPR Mflv_0405|M.gilvum_PYR-GCK GFLAELERELPAAPAQQGPAVTASGRTPLVERLTTAPLQQRKRLLTDYLR MAB_0939|M.abscessus_ATCC_1997 GFLAELDREVPSHLA--GVAGAQSGSTQLVERLANAPVQQRKKLLTDYLR MSMEG_0408|M.smegmatis_MC2_155 AFLSELESELPAAATGAAAPATVPGKPPLVEQLTKAPVQQRKSLITNYLR Mvan_1003|M.vanbaalenii_PYR-1 AFLSQLEREVPDVPD--ASAPAPSGTTRFVEELTLAPVEQRRKLVLEYLR Mb2971c|M.bovis_AF2122/97 ---------MIEEQRTMSVEGADQQSEKLFHYLKKVAVELD--------- MLBr_00135|M.leprae_Br4923 --------------MTASVEGADQKSEKLISYLKKVVVELD--------- MUL_2005|M.ulcerans_Agy99 --------------MTTSGESADQQNDKLFRYLKKVAVELD--------- MMAR_3099|M.marinum_M GTLQAQA-LLVDRRTDDEPVGAAPTTEQLLSVVCGQAAEVLGIGAASVDI MAV_3108|M.avium_104 ----------------------MPGTEQHLDYLKRLTADLR--------- Rv2048c|M.tuberculosis_H37Rv PMFSDLA-SAPTRRQVDDSVAAAKSKSALAHRLHGLPEAEQHAVLLGLVR TH_4458|M.thermoresistible__bu PAQPVPAADEQADEQAGAGPGAGPGADEIRAWFVAQLAGELGLSPDDIDT . Mflv_0405|M.gilvum_PYR-GCK DAVAEVTRVDAAEIREDAGFFDLGMDSLMAVELRRRIETGVGKEIPVTLV MAB_0939|M.abscessus_ATCC_1997 DAVAEVTRVDVSEIREDAGFFDLGMDSLMAVELRRRMEQGVGKEIPVTLV MSMEG_0408|M.smegmatis_MC2_155 NAVAEVTRVDADEIRDEAGFFDLGMDSLMAVELRRRIEQGVGKDIPVTLV Mvan_1003|M.vanbaalenii_PYR-1 AAVAEVTRVDAAEIRDEAGFFDLGMDSLMAIELRRRLEQGLGKELPVTLA Mb2971c|M.bovis_AF2122/97 -------------------------------------------------- MLBr_00135|M.leprae_Br4923 -------------------------------------------------- MUL_2005|M.ulcerans_Agy99 -------------------------------------------------- MMAR_3099|M.marinum_M DRSLGDQGLNSIGVTELASRLTQVLGQDVQPVDIFNHPTVGDLVQILSPG MAV_3108|M.avium_104 -------------------------------------------------- Rv2048c|M.tuberculosis_H37Rv LHIATVLGNITPEAIDPDKAFQDLGFDSLTAVEMRNRLKSATG---LSLS TH_4458|M.thermoresistible__bu GQPFAYYGLDSVRAIQLMTALEAWSGIKVAPTLAYDHPTIDLAAEHLAGL Mflv_0405|M.gilvum_PYR-GCK MDHPRLSDAADYLLGDVLGLTEAAT-APKAATVVSTAADEPIAIVAVSCR MAB_0939|M.abscessus_ATCC_1997 MDHPRISDVADYLLGDVLGLAEQAKPAAQLASAVTGRTDEPIAIVAVSCR MSMEG_0408|M.smegmatis_MC2_155 MDHPRLSDAADYLLVEVLGLGEQTN--VRQASTVTARTDDPIAVVAVSCR Mvan_1003|M.vanbaalenii_PYR-1 MDHPHLSDAAEYVLGDVLGLSEHTV--AQPDTPSTVRTDDPIAIVGMACR Mb2971c|M.bovis_AF2122/97 -------ETRARLREYEQR------------------ATEPVAVVGIGCR MLBr_00135|M.leprae_Br4923 -------ETRARLREYEQR------------------ATEPVAVVGIGCR MUL_2005|M.ulcerans_Agy99 -------EARARLREYEQR------------------ATEPVAVVGIGCR MMAR_3099|M.marinum_M EKTRHQRGVRERLGHHAASGAG-----------AVALPADPVAIVGIGCR MAV_3108|M.avium_104 -------RTRRRVAELEGR------------------LSEPVAVVGMACR Rv2048c|M.tuberculosis_H37Rv PTLIFDYPTPNRLASYIRTELAGLPQEIKHTPAVRTTSEDPIAIVGMACR TH_4458|M.thermoresistible__bu THTATSTAADAGVSTGAGRRPEHGP--------APDRADEPIAIIGIGCR . : :*:*::.:.** Mflv_0405|M.gilvum_PYR-GCK FPG-APNPEAFWDLLSGGVDAIREVPEDR-FDIDEFYDPDPDAAGKTYTR MAB_0939|M.abscessus_ATCC_1997 FPG-APDPEAFWDVLSGGVDAIREVPEDR-FDIDEFYDPDPEVAGKTYTR MSMEG_0408|M.smegmatis_MC2_155 FPG-APDPESFWELLAGGVDAIREVPEDR-WDIDEFYDPDPDTPGKTYTR Mvan_1003|M.vanbaalenii_PYR-1 FPG-ADDTDAFWSVLAEGADLIREIPDDR-FDINEFYDPDPEAAGKIYSR Mb2971c|M.bovis_AF2122/97 FPGGVDGPDGLWDVVSAGRDVVSEFPTDRGWDVEGLYDPDPDAEGKTYTR MLBr_00135|M.leprae_Br4923 FPGGVDSPDRLWDVVSECRDVVSEFPTDRGWDVDGLFDPDPDAEGKTYTR MUL_2005|M.ulcerans_Agy99 FPGGADGPEGLWDLVSQGRDAVTEFPNDRGWDTEGLFDPDPDAEGKTYTR MMAR_3099|M.marinum_M FPGGVDSADSLWDMVVSARDVISDFPGDRGWDAGRLFDPDPDALGKTYCA MAV_3108|M.avium_104 YAGGVDSPEALWDLVIEGRDTVSDFPVDRGWDVEGLYDPDPDAKGKMYTR Rv2048c|M.tuberculosis_H37Rv YPGGVNSPDDMWDMLIQGRDVLSEFPADRGWDLAGLYNPDPDAAGACYTR TH_4458|M.thermoresistible__bu FPG-ADGPAAYWRLLREGRDAITATPPER-WDTDSVGDG---------TR :.* . .. * :: * : * :* :* . : Mflv_0405|M.gilvum_PYR-GCK YGGFLDHIDEFDPEFFGLSPREAVWIEPQQRLMLETVWEGLERAGYAPSA MAB_0939|M.abscessus_ATCC_1997 FGGFLDGIDGFDPEFFGISPREAVWIEPQQRLMLETVWEGLERAGYSPAA MSMEG_0408|M.smegmatis_MC2_155 FGGFLDGIDGFDPEFFGISPREAVWIEPQQRLMLETVWEGLERAGYAPSD Mvan_1003|M.vanbaalenii_PYR-1 YGGFLDGVDGFDPEFFGISPREAVWIDPQQRLVLETAWEGLERAGYSAAA Mb2971c|M.bovis_AF2122/97 WGAFLDDATGFDAGFFGIAPSEVLAMDPQQRLMLEVSWEALEHAGIDPLS MLBr_00135|M.leprae_Br4923 WGAFLDDAAGFDAGFFGIAPSEVLAMDPQQRLMLEVSWEALEYAGIDPLS MUL_2005|M.ulcerans_Agy99 WGAFVENATNFDAGFFGIPPSEVLAMDPQQRLMLEVSWEALEHAGIDPMS MMAR_3099|M.marinum_M VGGFLEDAAGFDAGFFGIAPREALAMDPQQRVLLEVSWEALEDAGIDPKA MAV_3108|M.avium_104 QGSFLQHAGDFDAGFFGIGPSEALAMDPQQRIMLEICWEALERAGIDPSA Rv2048c|M.tuberculosis_H37Rv TGGFVDGVGDFDPAFFGVGPSEALAMDPQHRMLLELSWEALERAGIDPTG TH_4458|M.thermoresistible__bu WGGFLERIDGFDAGFFGISPREAVRIDPQQRLLLEVAWEALEDAGLVPDR *.*:: **. ***: * *.: ::**:*::** **.** ** . Mflv_0405|M.gilvum_PYR-GCK LRGSRTGVFVGVAANEYAHLLSAESIDKIEPHFITGNALNAISGRVAFAL MAB_0939|M.abscessus_ATCC_1997 LRGSRTGIFAGVGANEYAHLLSSESIDKIEPYFITGNALNAISGRVAFAL MSMEG_0408|M.smegmatis_MC2_155 LRGSRTGVFTGVAANEYAHLLSAESIDKIEPHFITGNALNAISGRVAFAL Mvan_1003|M.vanbaalenii_PYR-1 LRGSRSGVYVGVGANEYSHLLSGGSLDGIEAQFITGNALNVIAGRVSFTL Mb2971c|M.bovis_AF2122/97 LRGSATGVYTGIFAASYGNRDT----GGLQGYGLTGTSISVASGRVSYVL MLBr_00135|M.leprae_Br4923 LRGSATGVFTGIFAPSYGSRDT----GGLQGYGLTGTAVSVASGRVSYVL MUL_2005|M.ulcerans_Agy99 LRGSSTGVFTGIFAPSYGGKDV----GALQGYGLTGSPVSVASGRVAYVL MMAR_3099|M.marinum_M LRGSATGVFVGTWAQPYGDGGS----DSADGYAMTGTATSVASGRVAYVL MAV_3108|M.avium_104 LRGTATGVFAGVIHAGYGGEVK----GELEGYGLTGSTLSVTSGRVSYVL Rv2048c|M.tuberculosis_H37Rv LRGSATGVFAGVMTQGYGMFAA----EPVEGFRLTGQLSSVASGRVAYVL TH_4458|M.thermoresistible__bu LAGSRTGVFTGVSTYDYLHLQLSHP-ELIDAYSGTGTASSIAANRLSYVF * *: :*::.* * : ** . :.*:::.: Mflv_0405|M.gilvum_PYR-GCK GLEGPAVAVDTACSSSLVAVHQATQALRSGDCDMALAGGVNVLLSPVTVV MAB_0939|M.abscessus_ATCC_1997 GFEGPAVAVDTACSSALVAVHQAVQALHSGDCDLALAGGVNVLLSPVTVI MSMEG_0408|M.smegmatis_MC2_155 GFEGPAVAVDTACSSALVAVHQACQALQSGDCDLALAGGVNVLLSPVTVV Mvan_1003|M.vanbaalenii_PYR-1 GLEGPAVAVDTACSSSLVAVHQACQGLQSGDCDLALAGGVNVLLSPATTI Mb2971c|M.bovis_AF2122/97 GLQGPAVSVDTACSSSLVAIHWAMSSLRSGECDLALAGGVTVMGLPSIFV MLBr_00135|M.leprae_Br4923 GLEGPAVSVDTACSSSLVAIHWAMSSLRSGECDLALAGGVTVMGLPSIFV MUL_2005|M.ulcerans_Agy99 GLEGPALSVDTACSSSLVAIHWAMASLRSGECDMALAGGVTVMGLPSIFV MMAR_3099|M.marinum_M GLEGPAVSVDTACSSSLVAVHQAVQSLRLGECDLALAGGVTVMATPSVFV MAV_3108|M.avium_104 GLEGPAVSVDTACSSSLVAMHLAAQSLRSGECDLALAGGVTVMATPAAFV Rv2048c|M.tuberculosis_H37Rv GLEGPAVSVDTACSSSLVALHMAVGSLRSGECDLALAGGVTVNATPDIFV TH_4458|M.thermoresistible__bu DFRGPSLTLDSACSSSLVAVHQACRSLRDGECDLALAGGVNIMLSAGIGL .:.**::::*:****:***:* * .*: *:**:******.: . : Mflv_0405|M.gilvum_PYR-GCK AASRARMLSPVGRCKTFDASADGYVRSEGCGILVLKRLSDAVRDGDRVCA MAB_0939|M.abscessus_ATCC_1997 AASRARMLSPVGRCKTFDASADGYVRSEGCGILVLKRLSDAERDGDRVLA MSMEG_0408|M.smegmatis_MC2_155 AASRARMLSPVGRCKTFDASADGYVRSEGCGVLVLKRLSDAVRDGDRVCA Mvan_1003|M.vanbaalenii_PYR-1 ATSRARMLSPDGRCKTFDAAADGYVRGEGCGILVLKRLSDAVRDGDRIQA Mb2971c|M.bovis_AF2122/97 GFSRQRGLAADGRCKAFAAAADGTGWGEGAGVVVLERLSDARRLGHSVLA MLBr_00135|M.leprae_Br4923 GFSRQRGLAADGRCKAFARAADGTGWGEGAGVVVLERLSDAQRLGHTVLA MUL_2005|M.ulcerans_Agy99 GFSRQRGLAADGRCKAFAAAADGTGWGEGAGVLVLERLSDAQRNGHNVLA MMAR_3099|M.marinum_M GFSRQRGLAPDGRCKAFAEAADGVGWGEGAGVLVLQRLSDARRQGRVVLG MAV_3108|M.avium_104 EFSRQRALAPDGRCKVYAGAADGTSWSEGAGVLVLERLADARRLGHPVWA Rv2048c|M.tuberculosis_H37Rv EFSRWRGLSPDGRCKAFAAAADGTGFSEGGGMLVLQRLSDARRLGHPVLA TH_4458|M.thermoresistible__bu NFTRAGVMATDGRCKTFDARADGWVRGEGAGIVVLKPLREALADEDPIYA :* ::. ****.: *** .** *::**: * :* : . Mflv_0405|M.gilvum_PYR-GCK VIAGSAVNQDGASSGLTVPNGGAQQRLIGTVLARAGITGGEVDYLEAHGT MAB_0939|M.abscessus_ATCC_1997 VIPGSAVNQDGASSGLTVPNGGAQQRLIGSVLARAGLVGGDVDYLEAHGT MSMEG_0408|M.smegmatis_MC2_155 VIPASSVNQDGASSGLTVPNGGAQQRLIEATLARAGLSGADVDYLEAHGT Mvan_1003|M.vanbaalenii_PYR-1 VIRGSAVNQDGASGGLTVPNGGAQQRVIAAALTRAGLSGSDIDYLEAHGT Mb2971c|M.bovis_AF2122/97 VVRGSAVNQDGASNGLTAPNGLAQQRVIQAALANAGLSAADVDVVEAHGT MLBr_00135|M.leprae_Br4923 VVRGSAVNQDGASNGLTAPNGLAQQRVIQAALTNAGLSSADVDVVEAHGT MUL_2005|M.ulcerans_Agy99 VVRGSAINQDGASNGLTAPNGLTQQRVIQAALANCGLTSADVDVVEAHGT MMAR_3099|M.marinum_M VVRGSAVNQDGASHGLTAPNGPAQQRVIRAALAGAGLGPADVDVVEAHGT MAV_3108|M.avium_104 VLRGSAVNQDGASNGLTAPNGPSQQRVIRAALANAGLSAVDVDVVEGHGT Rv2048c|M.tuberculosis_H37Rv VVVGSAVNQDGASNGLTAPNGPSQQRVVRAALANAGLSAAEVDVVEGHGT TH_4458|M.thermoresistible__bu VIRGSAVNQDGRTNGLMAPSRTAQEVVLTDAYRRAGVSPGVVQYVEAQGI *: .*::**** : ** .*. :*: :: . .*: :: :*.:* Mflv_0405|M.gilvum_PYR-GCK GTPLGDPIEVQAAAAAYAGAR-DADRPLLMGSVKTNIGHTESASGAAGLI MAB_0939|M.abscessus_ATCC_1997 GTPLGDPIEVQAAAAAYGGSR-DADRPLLMGSVKSNIGHTESASGAAGLI MSMEG_0408|M.smegmatis_MC2_155 GTPLGDPIEVQAAAAAYGAGR-DADRPLLMGSVKTNIGHTESASGAAGLI Mvan_1003|M.vanbaalenii_PYR-1 GTSLGDPIEVQAAGAVLGAGR-DPDRPLLMGSVKTNVGHLESASGVAGLI Mb2971c|M.bovis_AF2122/97 ATTLGDPIEAQALLSTYGQGR-PAEQPLWVGSIKSNMGHTQAAAGVAGVI MLBr_00135|M.leprae_Br4923 ATTLGDPIEAQALLATYGQGR-PADQPLWVGSIKSNMGHTQAAAGVAGVI MUL_2005|M.ulcerans_Agy99 ATTLGDPIEAEALLATYGQGR-PTDQPLWVGSIKSNMGHTQAAAGVAGVI MMAR_3099|M.marinum_M GTRLGDPIEAQALLAVYGQDR-EPGRPLWVGSIKSNMGHAQAAAGVAGVI MAV_3108|M.avium_104 GTVLGDPIEAQALLATYGQDR-PADRPLWLGSIKSNIGHTSAAAGVAGVI Rv2048c|M.tuberculosis_H37Rv GTTLGDPIEAQALLATYGQDRGEPGEPLWLGSVKSNMGHTQAAAGVAGVI TH_4458|M.thermoresistible__bu GTPVGDAIEVGALGTVLAEDR-PPDSPCLIGSVKTNIGHLEAAAGIAGLI .* :**.**. * :. . * . * :**:*:*:** .:*:* **:* Mflv_0405|M.gilvum_PYR-GCK KVVLSLQHETLPQSLHFDTPSPHIPWDSLPVRVVDTAMPWQ-PNGRPRRA MAB_0939|M.abscessus_ATCC_1997 KVVLSLQNGVLPQSLHFDNPSPHIPWESLPVRVVDKAIPWQ-ANGRPRRA MSMEG_0408|M.smegmatis_MC2_155 KVVLSLQHGVLPQSLHFENPSPHIPWDALPVRVIDEPVPWQ-TNGRVRRA Mvan_1003|M.vanbaalenii_PYR-1 KVVLSLQHEMLPRHLHFKTPSPHIPWDRLAVRVVAEPTPWR-ADGRPRRA Mb2971c|M.bovis_AF2122/97 KMVQAMRHGVMPATLHVDEPSPRVDWTSGAVSVLTEAREWS-VDGRPRRA MLBr_00135|M.leprae_Br4923 KMVQAMRHHVMPATLHVDEPSPRVDWTTGAVSVLTEARDWS-VEGRPRRA MUL_2005|M.ulcerans_Agy99 KMVQAMRHGLMPASLHVDEPSKRVDWESGAVSVLAEARDWP-DAGRPRRA MMAR_3099|M.marinum_M KMVQAMRHGLLPETLHVDEPSGQVDWSAGAVEVLSRARSWLGVPGRPRRA MAV_3108|M.avium_104 KMVQALRHGVMPKTMHVDVPSPHVDWSAGAVSLLTDPRPWP-EHGGPRRA Rv2048c|M.tuberculosis_H37Rv KMVLAMRHELLPATLHVDVPSPHVDWSAGAVELLTAPRVWP-AGARTRRA TH_4458|M.thermoresistible__bu KVALALRHRMIPPTLNFTEPNPTIEFDKLPVRVAQTLTPWP-DDSGRAVA *:. :::: :* ::. *. : : .* : * . * Mflv_0405|M.gilvum_PYR-GCK GVSSFGFTGTNAHVLIEEAPTDLAGPTEPTAPAEPVDEDAAADPAPAPVE MAB_0939|M.abscessus_ATCC_1997 GVSSFGFTGTNAHVLIEEAPQPQATP----------DEDDASTPQSAPVS MSMEG_0408|M.smegmatis_MC2_155 GVSSFGFTGTNAHVLVEEAPPQLHTADAAP----VEPAATAEAGTDDSPQ Mvan_1003|M.vanbaalenii_PYR-1 GVSSFGFSGTNAHVVLEEPPAQSADLRQPPTDGKDGAAGLESATAPEPAG Mb2971c|M.bovis_AF2122/97 AVSSFGISGTNAHLILEEAPVPAPAEAPVEASE------STGGP-RPSMV MLBr_00135|M.leprae_Br4923 GVSSFGISGTNAHVILEEAPT------PVEASY------STADQQRLSVV MUL_2005|M.ulcerans_Agy99 GVSSFGISGTNAHVILEEAPAP----EAVPDSE------SNKGEPSLPVV MMAR_3099|M.marinum_M GVSSFGISGTNAHVIVEQALPEVAESGGVSGVCGQ-GVGSVESVVRASVV MAV_3108|M.avium_104 GVSSFGISGTNAHVIVEQAPAA----AETEAAP-------ASSTMPDAVV Rv2048c|M.tuberculosis_H37Rv GVSSFGISGTNAHVIIEAVPVVP----------------RREAGWAGPVV TH_4458|M.thermoresistible__bu GVSAFGFGGTNAHVVLAEAPQVR-------------AAATADDHADGFVE .**:**: *****::: Mflv_0405|M.gilvum_PYR-GCK VLPLSARSPEALVALAQRYETWLTAHPEADLADVCRTAGTGRSHFEHRAA MAB_0939|M.abscessus_ATCC_1997 VLPLSARSPEALAAVAQRYESWLAAHPDVDLEDVCLTAGRGRSHFEHRAA MSMEG_0408|M.smegmatis_MC2_155 VLALSARSPEALVELARRYDDWLSATPGLDIADVCHTAGVGRSHFEYRAA Mvan_1003|M.vanbaalenii_PYR-1 VLPISARSPEALTALARRYESWLTAHPDADIADVCYTAGAGRSHFEHRAA Mb2971c|M.bovis_AF2122/97 PWVISARSAEALTAQAGRLMAHVQANPGLDPIDVGCSLAS-RSVFEHRAV MLBr_00135|M.leprae_Br4923 PWVVSGRSTAALMAQASRLAFYVQADPEVDPVDVGCALAA-RSVFEHRAV MUL_2005|M.ulcerans_Agy99 PWVISARSAEALTAQAGRLLAHVQADPQSNPVDIGFSLAG-RSAFEHRAV MMAR_3099|M.marinum_M PWVLSAQSRQALVAQASRLLGRVGGDDGLDPVDVGLSLAQ-RCVFEHRAV MAV_3108|M.avium_104 PWVVSARSAEALAGQARRLLDHVTADAQASPLDVGWSLVSTRAVFEHRAV Rv2048c|M.tuberculosis_H37Rv PWVVSAKSESALRGQAARLAAYVRGDDGLDVADVGWSLAG-RSVFEHRAV TH_4458|M.thermoresistible__bu ILPLSARSQAALDALAERYESALTG--GVPPADLCHTAGARRAHHDHRLA :*.:* ** * * : . *: : *. .::* . Mflv_0405|M.gilvum_PYR-GCK LVVDSVESARIALTDLAQNRLRPGVVRG--EHLNHPTTAWMFTGQGSQYP MAB_0939|M.abscessus_ATCC_1997 LVVDSIQTAREGLLELAQNRLRPGVVRG--EHTNHPTTAWLFTGQGSQYP MSMEG_0408|M.smegmatis_MC2_155 LVVDSVERAREGLAALAEGRTPAGVVRG--EHVHRPTTAWLFTGQGSQYP Mvan_1003|M.vanbaalenii_PYR-1 LVVDSVDGARDLLAGLAEDRLGPGAVRG--VCGDPPKTAWLFTGQGSQYP Mb2971c|M.bovis_AF2122/97 VVGASREQLIAGLAGLAAGEPGAGVAVG--QPGSVGKTVVVFPGQGAQRI MLBr_00135|M.leprae_Br4923 VVGESREQLIAGLAGLAVGESGAGVAIG--QAAPLGKTVVVFPGQGAQRI MUL_2005|M.ulcerans_Agy99 VVGADRQQLLTGLATLADGAPGAGVVTG--QAGSVGKTAVVFPGQGSQRI MMAR_3099|M.marinum_M VVGRDREALLAGLTGLARGGPGAGVVVG--QAAAVGKTVLVFPGQGAQWT MAV_3108|M.avium_104 VVGRERGALATGLAGLASGRPGPATVVG--RARSTGKTVLVFPGQGSQTL Rv2048c|M.tuberculosis_H37Rv VVGGDRDRLLAGLDELAGDQLGGSVVRG--TATAAGKTVFVFPGQGSQWL TH_4458|M.thermoresistible__bu VVGASRAELIGALAAYRRGEPHPGVFTGRSQSGHRSGVVFVFSDEGSQWR :* . * . .. * .. :*..:*:* Mflv_0405|M.gilvum_PYR-GCK GMARELFDTEPVFADTVTRCADAVADLLPRPLLDVMFAGGREAGVPPTET MAB_0939|M.abscessus_ATCC_1997 GMARELFDAEPVFAETVTRCAEAVKDIVTRPLLEVMFATDRETGGKAGEA MSMEG_0408|M.smegmatis_MC2_155 GMARELFDTQPVFAQTVRQCAEAVADMLPRPLLDVLFATDRET----ADL Mvan_1003|M.vanbaalenii_PYR-1 GMARELFDTEPVFRDTVTRCAEAIGDTLPRPLLEVLFDTDGDN----GQT Mb2971c|M.bovis_AF2122/97 GMGRELYGELPVFAQAFDAVADELDRHLRLPLRDVIWGADADL------- MLBr_00135|M.leprae_Br4923 GMGRELCSQLPVFAEEFDAVTGELDRHMRLPLRDVVWGADAGL------- MUL_2005|M.ulcerans_Agy99 GMARELHDQLPVFAEAFDAVADELDRHLRIPLCEVMWGSDVAL------- MMAR_3099|M.marinum_M GMGRGLHGQFPAFARAFDAAVDELDQHLPMPLREVMWGTDKGL------- MAV_3108|M.avium_104 GMGRQLYERFEVFAGALDEAVAVVDEHSRLSVREVMWGADPEL------- Rv2048c|M.tuberculosis_H37Rv GMGMGLHAGYPVFAEAFNTVVGELDRHLLRPLREVMWGHDENL------- TH_4458|M.thermoresistible__bu GMAQRLYAEDQVFRTALAECDRALRRHMEISPLSELLADPSHSR------ **. * .* . : . . : Mflv_0405|M.gilvum_PYR-GCK LRHTSFAQPALFAVEMGLARLWQSWGIVPDVVLGHSVGQYAAACVAGVFS MAB_0939|M.abscessus_ATCC_1997 LRHTSFAQPALFAVEMGLARLWQSWGIEPDVVLGHSVGQYAAACVAGVFS MSMEG_0408|M.smegmatis_MC2_155 LQHTSFAQPALFAVEMGLARLWQSWAIEPDVVLGHSVGQYAAACVAGVFS Mvan_1003|M.vanbaalenii_PYR-1 LRHTSYAQPALFAIEMGLARLWQARGIEPDVVLGHSVGQYAAACVAGVFG Mb2971c|M.bovis_AF2122/97 LDSTEFAQPALFAVEVASFAVLRDWGVLPDFVMGHSVGELAAAHAAGVLT MLBr_00135|M.leprae_Br4923 LDSTEFAQPALFAVEVALFAVLQHWGLQPDFVMGHSIGELAAAYVAGVLA MUL_2005|M.ulcerans_Agy99 LDSTEFAQAALFAVEVALFAALQRWGLQPDFVMGHSVGELSAAYVAGVLT MMAR_3099|M.marinum_M LDSTEFAQPALFALEVGLWALLEHWGIRPDFVLGHSVGELSAAHVAGVLS MAV_3108|M.avium_104 LQSTEFAQPALFVFEVALAALWESLGVTPDVVMGHSVGEIAAACVAGVLS Rv2048c|M.tuberculosis_H37Rv LNSTEFAQPALFAVEVALFRLLGSWGVRPDFVMGHSIGELSAAHVAGVLS TH_4458|M.thermoresistible__bu MDEVTIASPALFAVQVALAALWQSWGVEPAAVIGHRMGEVAAAHVAGVLG : . *..***..::. .: * *:** :*: :** .***: Mflv_0405|M.gilvum_PYR-GCK LEDGARLMAERGRLFGSLPEGGRMVAVFADAKRVEQVAADFP-RVSVGAY MAB_0939|M.abscessus_ATCC_1997 IEDGARLIAERGRLFGGLPAGGRMVAVFSDAKHVEQIAGEFP-RVSVGAY MSMEG_0408|M.smegmatis_MC2_155 LDDGARLMAERGRMFGSLPEGGRMVAVFADAEHVEQVAGEFP-RVSVGAY Mvan_1003|M.vanbaalenii_PYR-1 LEDGARLVADRGRLFGGLPVGGRMVAVFTDAEVVEDFADEFP-QVSVAAY Mb2971c|M.bovis_AF2122/97 LADAAMLVVARGRLMQALPAGGAMVAVAASEDEVEPLLGEG---VGIAAI MLBr_00135|M.leprae_Br4923 PADAAMLVVARGRLMQSMPAGGTMWAVAASEDEVVSLLGEG---VGIAAI MUL_2005|M.ulcerans_Agy99 LVDAAMLVVARGRLMQALPAGGAMVAVAAAEDEVLPSLTDG---VGIAAI MMAR_3099|M.marinum_M LADAAMLVAARGRLMQGLPAGGVMVALGVGEQEVDPLLAESAHPVSIAAI MAV_3108|M.avium_104 LRDAARLVAARGALMAALPPGGVMVAVTAGESQVGPLLGGG---VSIAAV Rv2048c|M.tuberculosis_H37Rv LENAAVLVAARGRLMQALPAGGAMVAVQAAEEEVRPLLSAE---VDIAAV TH_4458|M.thermoresistible__bu LDDAAALLCGRTRLSRLASTG----------------------------- :.* *: * : . * Mflv_0405|M.gilvum_PYR-GCK NGP-NTVLSGPGEDLEQIVGTFGEDGIRCTWLETSHAFHSELLDPVLDEF MAB_0939|M.abscessus_ATCC_1997 NGP-NTVLSGPGEDLEQAVARFQEEGIRCTWLETSHAFHSELLDPILDEF MSMEG_0408|M.smegmatis_MC2_155 NGP-NTVLSGPGEDLEEIVERFEDEGIRCTWLATSHAFHSELLDPVLDEF Mvan_1003|M.vanbaalenii_PYR-1 NGP-NTVLAGPASDLEQIVAGCSGEGIRTTWLDTSHAFHSALLDPVLDEF Mb2971c|M.bovis_AF2122/97 NAPESVVISGAQAAANAIADRFAAQGRRVHQLAVSHAFHSPLMEPMLEEF MLBr_00135|M.leprae_Br4923 NAPESVVISGPQAAVSAIADKFAAQGRRVHQLAVSHAFHSPLMEPMLEEF MUL_2005|M.ulcerans_Agy99 NAPKSVVISGAEAAVTAISDQFAQQGRRVHRLAVSHAFHSPLMEPMLEEF MMAR_3099|M.marinum_M NAPEQVVISGAQAAVMTIADQLAARGHRVQQLAVSHAFHSPLMEPIVEEF MAV_3108|M.avium_104 NGPDAVVLSGEQEAVAAVADRLAGSGARVHRLAVSHAFHSALMEPMLDGF Rv2048c|M.tuberculosis_H37Rv NGPASLVISGAQNAVAAVADQLRADGRRVHQLAVSHAFHSPLMDPMIDEF TH_4458|M.thermoresistible__bu --------------------------------------------AVREGL .: : : Mflv_0405|M.gilvum_PYR-GCK ESYAAQLQFAAPTLPLVCNRTGAVLTGQT-SLDAQYWRRHSRQPVQFAES MAB_0939|M.abscessus_ATCC_1997 ESYAAQVQFAAPTLPLVCNRTGAVLTAQT-PIDGQYWRRHSRQPVQFAES MSMEG_0408|M.smegmatis_MC2_155 EAYAAQFQFAAPTLPLVCNRTGAVLTGQT-PLDAQYWRRHSRQPVQFAES Mvan_1003|M.vanbaalenii_PYR-1 ESCAARLAYAAPTRPLVCNRTGAVVTGPG-VIDAQYWRRHARQPVQFAES Mb2971c|M.bovis_AF2122/97 ARVAARVQAREPQLGLVSNVTGELAGPD--FGSAQYWVDHVRRPVRFADS MLBr_00135|M.leprae_Br4923 VRVAAQVEVRKPQIGLVSNVTGELAGPD--FGSPQYWGEHVSRAVRFVDS MUL_2005|M.ulcerans_Agy99 ARIAAQVEAREPQIALVSNVTGELASADGGFGSAQYWVEHVRRAVRFADS MMAR_3099|M.marinum_M AEIAGRVTVEAPRIGVISNLTGELAGPG--YGSKAYWREHIRRPVRFSDS MAV_3108|M.avium_104 AAAAAGIEPRPPRIPLVSNLTGQLAGPG--YGTPQYWVDHVRRPVRFVDG Rv2048c|M.tuberculosis_H37Rv AAVAAGIAIGRPTIGVISNVTGQLAGDD--FGSAAYWRRHIRQAVRFADS TH_4458|M.thermoresistible__bu DGLLANLRPDDPRIPLYSTVTGDAVTGRG--FGAAHWMENLHSPVRFSAA . . * : .. ** :* : .*:* . Mflv_0405|M.gilvum_PYR-GCK VRTVAALGCSVLMEIGPQPVLTGAAVQVWPEHLAAPRAIASLRKGVADRR MAB_0939|M.abscessus_ATCC_1997 VRTVAALGCSVLMEIGPQPVLTGAAVQVWPEHLAPPRAIVSLRKGVEDRR MSMEG_0408|M.smegmatis_MC2_155 VRTVAALGCSVLMEIGPQPVLTGAAVQVWPEHMAAPRAVASLRKGVADRR Mvan_1003|M.vanbaalenii_PYR-1 VRTLADLGCSVLMEIGPQPFLIAAALRVWPESAATPRAIPSLRKGPDARR Mb2971c|M.bovis_AF2122/97 ARHLQTLGATHFIEAGPGSGLTGSIEQSLAP--AEAMVVSMLGKDRPELA MLBr_00135|M.leprae_Br4923 ARHLQTLGATHFIESGPSSGLMGAIEQSLAP--AEAVVVSMMGKDRPELA MUL_2005|M.ulcerans_Agy99 ARQLHTLGVTHFVEVGPGSGLTGSIEQSLAP--AEAVVVSMLGKDRPEVA MMAR_3099|M.marinum_M VACARAQGATHFVEAGPGAGLTAAIEQSLGS--VAATVVAVLGKQRPEPD MAV_3108|M.avium_104 VRLAESQGAGVFLEVGPGAALTSAVEQSLTS--DRAMSVVTMPKGRPEVD Rv2048c|M.tuberculosis_H37Rv VRFAQAAGGSRFLEVGPSGGLVASIEESLPD--VAVTTMSALRKDRPEPA TH_4458|M.thermoresistible__bu VRRLLGRGHDAFLEISAHPMLLSAVQEDAADLGRSCTTLVSMRRGECGRD . * ::* .. * .: . : : : Mflv_0405|M.gilvum_PYR-GCK QIADALAAAYIGGHKPDFAALHEQ-RGVRLELPTYPFQRRRFWPK---SA MAB_0939|M.abscessus_ATCC_1997 QIADALASAYVSGHRPNFAALQRH-PRRTVELPTYPFQRRRFWPK---SS MSMEG_0408|M.smegmatis_MC2_155 QIADALASAYVGGHRPDFAAVHRQ-PRRPVELPTYPFQRRRFWPK---AS Mvan_1003|M.vanbaalenii_PYR-1 QLAEAVAAAYIAGHRLDFTGHDGG-PHRRLPLPTYPFQHRSYWPK---TA Mb2971c|M.bovis_AF2122/97 SALGAAGQVFTTGVPVQWSAVFAGSGGRRVQLPTYAFQRRRFWETPGADG MLBr_00135|M.leprae_Br4923 SVLGAAGQLFATGMPVEWPAVFAGSSRRRVTLPTYAFQRRRFWETPGTDG MUL_2005|M.ulcerans_Agy99 SVLTAFGQLFSTGMSVDWPAVFAGSGATRVDLPTYAFQRRRFWEVPGADG MMAR_3099|M.marinum_M SLLDAAAQLFASGARLDWPAVFLGWGGRRVSLPTYAFMRQRFWLTPHLAG MAV_3108|M.avium_104 SLLTAAARLFTAGADVRWSAAFTGLHARRVDLPTYAFARRRFWLSGDAVG Rv2048c|M.tuberculosis_H37Rv TLTNAVAQGFVTGMDLDWRAVVG--EAQFVELPTYAFQRRRFWLS-GDGV TH_4458|M.thermoresistible__bu VLMTSLAALYASGHAVDWARVHPH-GSHCTAAPTYPWQRQRFWLDIDRCD : . : * : ***.: :: :* Mflv_0405|M.gilvum_PYR-GCK GMAIDGRVGASAGSGILGSGKD-LASGDSVYTSRLSVKTQPWLSDHVIYG MAB_0939|M.abscessus_ATCC_1997 GTAIEG--GGGLPSGILGRGED-LASGDSVYISRLSVRSQPWLSDHVIYG MSMEG_0408|M.smegmatis_MC2_155 SIAVDG---GTAASGILGSGKD-LASGDTIYTSRLSVKSQPWLADHVIYG Mvan_1003|M.vanbaalenii_PYR-1 GIRSDG----SSGSGLLGSAQD-LASGDIVHTSRLSVKTQPWLSDHVIYG Mb2971c|M.bovis_AF2122/97 PADAAGLGLGATEHALLGAVVERPDSDEVVLTGRLSLADQPWLADHVVNG MLBr_00135|M.leprae_Br4923 TASVSGLGLGSTEHALLGAVVERPDSGGVVLTGRLSLANQPWLADHVIGG MUL_2005|M.ulcerans_Agy99 PADATGLGLGGAEHALLGAVVERPDSGGVVLTGRLALADQPWLADHVIGG MMAR_3099|M.marinum_M SVGAAELGSGNPRHPLLDAVVEHPDSGEVILAGRLSRRAQPWLADHVIGG MAV_3108|M.avium_104 SANIASLGLAEAEHPLLGAVLDRPDSGGVVLTGRLSTAAQPWLADHAVAG Rv2048c|M.tuberculosis_H37Rv AADAAGLGLAASEHALLGAVIDLPASGGVVLTGRLSPSVQGWLADHSVAG TH_4458|M.thermoresistible__bu TGDGAGTG------------------------------------------ Mflv_0405|M.gilvum_PYR-GCK TVVVPGATYAAMALAAVGTP--AHAKDVFFYEPIILPEKSSREVQLTVHP MAB_0939|M.abscessus_ATCC_1997 TVVVPGATYAAMALAAVGTP--ARAKDVFFYEPIILPEKSSREVQLTLHP MSMEG_0408|M.smegmatis_MC2_155 TVVVPGATYAAMALAAVGTP--ARLKDVFFYEPIILPEKASREVQLTLHP Mvan_1003|M.vanbaalenii_PYR-1 TVVVPGATYAAMALAAMPTP--ARVQEVFFYEPIILGDKDSREVQLMLHR Mb2971c|M.bovis_AF2122/97 VVLFPGAGFVELVIRAGDEVGCALIEELVLAAPLVMHPGVGVQVQVVVG- MLBr_00135|M.leprae_Br4923 VVLFPGAGFVELVIRAGDEVGCAGVEELVLAAPLVLHPGSGVQVQVVVA- MUL_2005|M.ulcerans_Agy99 VVLFPGAGFVELAIRAGDEVGCAVVEELVLAAPLVLHPGMGVQVQVIVG- MMAR_3099|M.marinum_M LVLLPGTGFVELVIRAGDQLGCAAIDELTLTNPLIVPDGSEVQVQVVVG- MAV_3108|M.avium_104 TVLFPGAGFVELALRAGDEVGCPVVEELTLSAPLSLPAGGTVQLQVVVAD Rv2048c|M.tuberculosis_H37Rv VTIFPGAGFVELAIRAGDEVGCGVVDESTLAAPLVLPASGSVAVQVVVN- TH_4458|M.thermoresistible__bu ----------------------GTAERTVVPAPLPAPS------------ . . *: Mflv_0405|M.gilvum_PYR-GCK SVDGE-SKFQVHSRPYGERGAEWALNAEGVVASGVGD---SPAAAGDLED MAB_0939|M.abscessus_ATCC_1997 LEDGSGSKFQVHSRPYGERDVDWSLNAEGTVVTGIGDDAEPAPEAAEPAE MSMEG_0408|M.smegmatis_MC2_155 ADGGSVLSFQIHSRPYGERGADWSLNAEGTVDTAGSD---PDAAADEQSD Mvan_1003|M.vanbaalenii_PYR-1 TDDADGWTFEVHSRPYGDRDADWSRNASGTVAAGVGD-----AAPDAAAD Mb2971c|M.bovis_AF2122/97 AADESGHRAVSVYSRGDQSQG-WLLNAEGMLG---------VAAAETPMD MLBr_00135|M.leprae_Br4923 AADESSRRAVSVYSRGDQSHGGWLLNAEGLLE---------VDAAEATVD MUL_2005|M.ulcerans_Agy99 TADDSGNRALSVYSRGDKSED-WLLNAEGMLG---------VEAASSGAD MMAR_3099|M.marinum_M AAERSGRRTVSVYSRADHIGAAWVQHAEGALG---------VDPMPASGD MAV_3108|M.avium_104 AAGQPGSRSVAVYSR--VAQSEWTLHAEGVLS---------EAAPAPAAE Rv2048c|M.tuberculosis_H37Rv GPDESGVRGVSVYSRGDVGTG-WVLHAEGALR---------AGSAEPTAD TH_4458|M.thermoresistible__bu ------------------------------------------ASAAPTVD : Mflv_0405|M.gilvum_PYR-GCK PVDEAIERLNRMRPQELFETFADLELAWGPTWSGSLKSLWLGEGEAIGDI MAB_0939|M.abscessus_ATCC_1997 PVDAAIERMERMRPMELFEIFADLELAWGPTWSGSLKSLWLGEGEAIGDV MSMEG_0408|M.smegmatis_MC2_155 PVDEVIERLERMRPQDLFETFADLELAWGPTWSGSLKSLWLGDGEAVGDI Mvan_1003|M.vanbaalenii_PYR-1 PVDNAIERLTRTRPQQLFDAFADNDLAWGPAWCSSLRSLWVGTGEAVGDI Mb2971c|M.bovis_AF2122/97 LSVWPPEGAESVDISDGYAQLAERGYAYGPAFQG-LVAIWRRGSELFAEV MLBr_00135|M.leprae_Br4923 LSLWPPEGAESVDISDAYPQLAERGYAYGPAFQG-LVAIWRRGSELFAEV MUL_2005|M.ulcerans_Agy99 LSVWPPEGAESVDISDGYAQLADRGYAYGPGFQG-LVGVWRRDSELFAEV MMAR_3099|M.marinum_M FSVWPPSGAEAVRVSDAYERLAQLGYRYGPAFRG-IEAIWRRGTEVYAEV MAV_3108|M.avium_104 LSVWPPADAEAVDVAGGYDDLAGRGYGYGPAFRG-LRAVWRRGAETFAEV Rv2048c|M.tuberculosis_H37Rv LAMWPPAGAVPVEVADGYQQLAERGYGYGPAFRG-LTAMWRRGDEVFAEV TH_4458|M.thermoresistible__bu EVLLCADQRERRELLESYLR------------------------------ : Mflv_0405|M.gilvum_PYR-GCK LVGAELAEQLGTEPMHPVLMDLCTGVAFPAFPALLAAEQGVNDLYLPLRY MAB_0939|M.abscessus_ATCC_1997 LVGEELAEQLGTEPMHPVLMDLCTGVAFPAFPALLAAEQGVNDLFLPLRY MSMEG_0408|M.smegmatis_MC2_155 LVGAELAEQLGSEPMHPVLMDLCTGVAFPAFPALLAAEQGVNDLFLPLRY Mvan_1003|M.vanbaalenii_PYR-1 AVGAELGEHLGREPIHPVLLDLCTGIAGAALLAAAAQTDADPELFLPLRY Mb2971c|M.bovis_AF2122/97 VAPGEAGVAVDRMGMHPAVLDAVLHALG---LAVEKTQ-ASTETRLPFCW MLBr_00135|M.leprae_Br4923 VAP--TGVVVDGMGMHPALLDAVLHALG---LAIENTQ-ATTEMRLPFCW MUL_2005|M.ulcerans_Agy99 VAP--SGVAVDKMGMHPVVLDAVLHALG---LTAEQNP-DSDETKLPFCW MMAR_3099|M.marinum_M AIPADAELGINGYGIHPVLLDAVLQAAA---VAVD-----SGDTRLPYSW MAV_3108|M.avium_104 ELPEQAGVSTGRFGIHPVLLDAALHALG---VADKR-----LETVLPFSW Rv2048c|M.tuberculosis_H37Rv ALPADAGVSVTGFGVHPVLLDAALHAVV---LSAESAERGQGSVLVPFSW TH_4458|M.thermoresistible__bu ------DRVAAELGVLPPLLDVAAPLST---------------------- : * ::* Mflv_0405|M.gilvum_PYR-GCK GQVSLQEKMPRRFYCRATWHEAPLDSETQVFDLEYLDRDGRHLGGVREFT MAB_0939|M.abscessus_ATCC_1997 GQVTLKEKMPRRFYCRARWHESPLDSETQVFDLDYLDRDGRHLGGIREFT MSMEG_0408|M.smegmatis_MC2_155 GQVTLAEKMPRRFYCRARWHRSALDSETQVFELEFVDLGGRALGGIREFT Mvan_1003|M.vanbaalenii_PYR-1 GRVEVRERMPRRFYCRARWQTGGIDSETQVFDLDFLDHDGRNLGGIREFT Mb2971c|M.bovis_AF2122/97 RGVSLHAGGAGRVRARFASAG------ADAISVDVCDATGLPVLTVRSLV MLBr_00135|M.leprae_Br4923 RGVSLHAGGAGRVRARFTSAG------ADAIAVDIADSAGLPVLTVRSLV MUL_2005|M.ulcerans_Agy99 RGVSLHAGGAGRVRARLTMSG------PDSISVEIADAAGLPVLTVGALV MMAR_3099|M.marinum_M RGISLHAAAAKRIRARIAPVG------EVGYAVECADVAGLPVLTMGSLV MAV_3108|M.avium_104 QGVSLHAAGASRVRVRLAPAG------AGAVSVELADASGVPVLSVRELV Rv2048c|M.tuberculosis_H37Rv QGVSLHAAGASAVRARIAPVG------PSAVSIELADGLGLPVLSVASML TH_4458|M.thermoresistible__bu ------------------------------------------------LG : Mflv_0405|M.gilvum_PYR-GCK VKRAPREALLRGLGGDAT----RLLYTLGWHEVPVP----ESGDGAAPQG MAB_0939|M.abscessus_ATCC_1997 VKRAPREALLRGLGGDAT----RLLYTLGWHEVAVPPVAGEGEESAASIG MSMEG_0408|M.smegmatis_MC2_155 VKRAPREALLRGLGGDAT----RLLYTLGWHEVPPP------PSADDAVG Mvan_1003|M.vanbaalenii_PYR-1 VKRAPREALLRGLGADAT----RLIYRVGWRETSPP---VRDDGALGPSS Mb2971c|M.bovis_AF2122/97 TRPITAEQLRAAVTAAGG-ASDQGPLEVVWSPISVV------SGGANGSA MLBr_00135|M.leprae_Br4923 TRAMTAEQLRTAVTAAGG-ALEQGPMDLVWSPIPLS------SDGHGG-G MUL_2005|M.ulcerans_Agy99 TRAMSAAQLRAAVAEAGGGAPDQGPLDVIWSPIPLS------GSGTNGSA MMAR_3099|M.marinum_M TRPVSAEQLHAGAATAIG-RPAQGLLELAWSPISPA------HGALDGGG MAV_3108|M.avium_104 TRAVSAEQLAAAVAVRSG---SGELLDVAWSVIEPR------NSLPDNPI Rv2048c|M.tuberculosis_H37Rv ARPVTDQQLRAAVSSSGP----DRLFEVTWSPQP-----------SAAVE TH_4458|M.thermoresistible__bu IDSLTAAELRARVERDLG-------------------------------- . * Mflv_0405|M.gilvum_PYR-GCK TWLIGGFDELAVSVPGCIPADR----------------TNPESLRQLLTD MAB_0939|M.abscessus_ATCC_1997 TWLIAGFDELAAKVPGCIPLNRE---------------TDPELLGEVLVA MSMEG_0408|M.smegmatis_MC2_155 TWLIAGFDELAAKVPGCVPIDRN---------------TDLQVLGEVLSQ Mvan_1003|M.vanbaalenii_PYR-1 TWLVAGLDALADDVPGSIRIGFDRIWDPDRDGRVVLDPADDEHWRRLFAL Mb2971c|M.bovis_AF2122/97 PPAPVSWADFCAGSDG---------------------------------- MLBr_00135|M.leprae_Br4923 LPSVVSWADYCAGRGN---------------------------------- MUL_2005|M.ulcerans_Agy99 QPAVVSWADFCAGGDGGAA---G--------------------------- MMAR_3099|M.marinum_M HQTVLSWADFTAGAAAAADGVGG--------------------------- MAV_3108|M.avium_104 SEGVTVWEPAAVDGAG---------------------------------- Rv2048c|M.tuberculosis_H37Rv PLPVCAWGTTEDSAAV---------------------------------- TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK AHGRGLPFSGVVWRAARSDGDES--DAEVAARLEAEIAELLGAVHTVQ-- MAB_0939|M.abscessus_ATCC_1997 AKERGVPFSGVVWRAAGPGATES--TTESAARLEGEIAHLLSAVHTVQNS MSMEG_0408|M.smegmatis_MC2_155 AHARGAGFSGVVWRCATPGRKESGSASAESARLEAEITNLLSAVHAAQ-- Mvan_1003|M.vanbaalenii_PYR-1 ADERRAPVAGVVLGVTGRARPEE-PSADFAARLEAQIRDVLGAVHSLS-- Mb2971c|M.bovis_AF2122/97 -------DASVVVWELESAGGQASS---VVGSVYAATHTALEVLQSWLG- MLBr_00135|M.leprae_Br4923 -------DTGVVVWEFGSASAGAQAPVDSVAAVYSATHAALQVLQFWFG- MUL_2005|M.ulcerans_Agy99 -------DAGVVVWEPNPAG------EDVVGPVYAATHAALEVLQSWFD- MMAR_3099|M.marinum_M -------RAVAVVWESRTAET------DVVGSVYARIHAALSVLQHWLA- MAV_3108|M.avium_104 -----------------------------PAAVHAATHQALGVLQSRLA- Rv2048c|M.tuberculosis_H37Rv ------------VFESVPLAG------DVVAGVYAATSSVLDVLQSWLT- TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK -GGEVKLPGGLWIVTERAVATESGEPVDPVQAALWGFGRTAINEEPALRC MAB_0939|M.abscessus_ATCC_1997 AQNGVKLPGGLWIVTERAVATESGEPVDPVQAALWGFGRTTINEEPALRA MSMEG_0408|M.smegmatis_MC2_155 -GPSVKLPGGLWIVTEHGVACESGEPVDPVQAALWGFGRTTINEEPALHC Mvan_1003|M.vanbaalenii_PYR-1 -ALGAKPAAGLWIVTERAVAAEAGEPVDPVQSALWGLGRTLIAEEPGLRC Mb2971c|M.bovis_AF2122/97 ----ADRAATLVVLTHGGVGLAGEDISDLAAAAVWGMARSAQAENP-GRI MLBr_00135|M.leprae_Br4923 ----QDRAGTLVVLTRGAVGLVGEGISDLAAAAVWGMVRSAQSEHS-GKI MUL_2005|M.ulcerans_Agy99 ----GDRAGTLVVLTHGAVAMPGENVSDLAGAAVWGIVRSAQAENP-GRI MMAR_3099|M.marinum_M ----QDQLASLVVVTHGAVGLPGEAITDLAGSAVWGLARSAQAESP-GRI MAV_3108|M.avium_104 ----GEAGGVLVVSTRGAVGLPGEDVADLAGAAVWGLVRSAQAEHP-GRV Rv2048c|M.tuberculosis_H37Rv ----RDGAGVLVVMTRGAVALPGEDVTDLAGAAVWGLVRSAQTEHP-GRI TH_4458|M.thermoresistible__bu ---------IVIPVAQLLNGPSVSDLAEWISTTMVGFGSTTPEPES---- : :. . : ::: *: : . Mflv_0405|M.gilvum_PYR-GCK RLVDCDGSPQAVQALAALLSTP-VDEPELAVRQGKLLASRLLPWSRSGHL MAB_0939|M.abscessus_ATCC_1997 KLVDGDGSPEAVQALARLLVTP-VDEPEIAVRQGKLLASRLLPWSRTGHL MSMEG_0408|M.smegmatis_MC2_155 RLVDCDGSSEAVDLLAALLAAPGIQEPEIAVRQGKLLASRLLPWARSGHL Mvan_1003|M.vanbaalenii_PYR-1 LLVDLDGSEDAGPALARLLGAP-GDEPELALRQGRLLVPRLLPWSRSGQL Mb2971c|M.bovis_AF2122/97 VLIDTDA----AVDASVLAGVG---EPQLLVRGGTVHAPRLSPAP--ALL MLBr_00135|M.leprae_Br4923 VLIDTDS----AVDVAVLADLG---ESQLLVRCNTVHAARLSPAP--QLL MUL_2005|M.ulcerans_Agy99 VLVDADA----AVEAAELVAVG---EPQLVVRSGAAHAARLAPAA--PLL MMAR_3099|M.marinum_M VLVDIDTP-N-TPDLGVLLAGR---EPQLVVRGDSVFCARLRPVE--APL MAV_3108|M.avium_104 VLVDTDG----SLDLATVIGCG---EPQLVVRDGVAYRARLRPAGRRALL Rv2048c|M.tuberculosis_H37Rv VLVDSDAP-LDDSALAAVVTTG---EPQVLWRRGEVYTARVHGSRAVGGL TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK TVPRGGD-YVLAPTERGAIDNLRLTDSEVPPPAE--GYVQVRVEAAGLNF MAB_0939|M.abscessus_ATCC_1997 TVPRGSD-YVLAPTERGAIDNLRITEKEVPAPDE--GYVQVRVEAAGLNF MSMEG_0408|M.smegmatis_MC2_155 TLPRGGD-FVLAPTERGAIDNLRLTETDVPEPDE--GYVQVRVEAAGLNF Mvan_1003|M.vanbaalenii_PYR-1 AIPRGTD-YVLAPTERGVLDNLRVSETEVTAPPE--GHVQVRVEAAGLNF Mb2971c|M.bovis_AF2122/97 ALPAAESAWRLAAGGGGTLEDLVIQPCPEVQAPLQAGQVRVAVAAVGVNF MLBr_00135|M.leprae_Br4923 ALPVGESMWRLAADGGGTLEDLVIQPCPEVQAPLQAGHMRVAVAAVGVNF MUL_2005|M.ulcerans_Agy99 AVPADESAWRLAAGGGGTLEDLVIEPCPEVQAPLAAGQVRVAVRAVGVNF MMAR_3099|M.marinum_M EVPVGQSAWQLSTGGGGTLADIVVQPCPPAQAPLEPGQVRVAVAAAGVNF MAV_3108|M.avium_104 ELPGPPAVWRLAAGDAGTLEDLAVQEHP--AAELAPGQVRVRVAAAGVNF Rv2048c|M.tuberculosis_H37Rv LVPPSDRPWRLAMSTAGTFENLRLELIPDADAPLGPGQVRVAVSAIAANF TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK RDVLNVLGLYPGDPGPIGGDFAGTVTQLGEGVTGLDVGQRVYGSMQGAFA MAB_0939|M.abscessus_ATCC_1997 RDVLNVLGLYPGDPGPIGGDFAGIVTQLGEGVTGVEVGQRVYGSMQGAFG MSMEG_0408|M.smegmatis_MC2_155 RDVLNVLGLYPGDPGPIGGDFAGTVTQLGAGVSGLEIGQRVYGSMQGAFA Mvan_1003|M.vanbaalenii_PYR-1 RDVLNALGLYPGDPGPIGGELAGVVTAPGPDVDGFDVGQRVFGFAVGAFA Mb2971c|M.bovis_AF2122/97 RDVVAALGMYPGQAPPLGAEGAGVVLETGPEVTDLAVGDAVMGFLGG-AG MLBr_00135|M.leprae_Br4923 RDVVAALGMYPGQAPPLGAEGAGVVIEIGPEVTGVAVGDAVMGFLGG-AG MUL_2005|M.ulcerans_Agy99 RDVVAALGMYPGAAPPLGAEGAGVVLEVGPQVSGVAVGDSVMGFLGG-AG MMAR_3099|M.marinum_M RDVLMALGMYPGAQPVLGGEGSGVVLEVGPQVSGVGVGDAVMGLIAG-VG MAV_3108|M.avium_104 RDVLVALGMYPGAA-QLGAEGAGVVTEVGAGVTDVAVGDAVMGIFGL-VG Rv2048c|M.tuberculosis_H37Rv RDVMIALGLYPDPDAVMGVEACGVVIETSLNKGSFAVGDRVMGLFPEGTG TH_4458|M.thermoresistible__bu ---------------------AGVPGRSRPPDGAVASGSGDGGRWIELLN .* . *. * Mflv_0405|M.gilvum_PYR-GCK SRFNVPGQFLAPIPDGVSAVEAATIPAAALTVRLSF-DWAQVKSGDKVLI MAB_0939|M.abscessus_ATCC_1997 SRFNVPAQFLAPIPDGISGVEAATIPAAALTVRLSF-DWAQLKPGDKVLI MSMEG_0408|M.smegmatis_MC2_155 SRFNVPAQFLAPIPDGIGAVEAATIPAAALTVRLAF-DWAQLKPGDKVLI Mvan_1003|M.vanbaalenii_PYR-1 SRVNVPVQFLAPVPEGISAVAAATTPAAVLTAGLAF-DWAALRAGDRVLI Mb2971c|M.bovis_AF2122/97 PLAVVDQQLVTRVPQGWSFAQAAAVPVVFLTAWYGLADLAEIKAGESVLI MLBr_00135|M.leprae_Br4923 PLAVVHQQLITQMPQGWSLAEAAAVPVVFLTALFGLADLAGIRAGESVLI MUL_2005|M.ulcerans_Agy99 PLSVVDQQLITRMPQGWSFAQAAAVPVVFLTALFGLQDLAKIQPGESVLI MMAR_3099|M.marinum_M PLAVVDARLLVRVPSGWSLAEAAGVPVAFLTAWYGLADLAGVRAGESVLV MAV_3108|M.avium_104 SEAAVDRRLVTRVPPGWSMAQAAGIPVVFLTAYYGLSVLAGLRAGQRVLV Rv2048c|M.tuberculosis_H37Rv TVASTDQRLLVKVPAGWSHTAAATTSVVFATAHYALVDLAAARSGQRVLI TH_4458|M.thermoresistible__bu QMPEVSDDTVDELLRQLLAAGENHDDTQLH-------------------- . : : . . Mflv_0405|M.gilvum_PYR-GCK HAASGGVGLAAVQMAQQCGAEVYATASTFKRATLRKLGVK--HVYDSRTT MAB_0939|M.abscessus_ATCC_1997 HAASGGVGLAAIQMAQQFGAEVFATASTFKRATLRKLGVK--YVYDSRTT MSMEG_0408|M.smegmatis_MC2_155 HAASGGVGLAAIQMAQQSGAEVFATASTFKRSTLRRLGVK--YVYDSRTT Mvan_1003|M.vanbaalenii_PYR-1 HAASGGVGLAAVQLARQRGATVFATASGYKRPMLRAMGVD--HVYDSRTT Mb2971c|M.bovis_AF2122/97 HAGTGGVGMAAVQLARQWGVEVFVTASRGKWDTLRAMGFDDDHIGDSRTC MLBr_00135|M.leprae_Br4923 HAGTGGVGMAAVQFARHWGVEIFVTASRGKWDTLRDMGFDDDHIGDSRTL MUL_2005|M.ulcerans_Agy99 HAGTGGVGMAAVQLARHWGVEIFVTASRGKWDTLRAMGFDDDHIGDSRTL MMAR_3099|M.marinum_M HAGTGGVGMAAVQLARLWGAKVFVTASRGKWDTLRSMGFDDSRIGDSRSL MAV_3108|M.avium_104 HAATGGVGMAAVQLARHWGAEVFATASRGKWDTLRAMGFDDAHIADSRTL Rv2048c|M.tuberculosis_H37Rv HAGTGGVGMAAVQLARHLGLEVFATASKGKWDTLRAMGFDDDHISDSRSL TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK DFAEQILADTDGAGVDVVLNSLTSEGFIEATLRATAQHGRFAEIAKRDIW MAB_0939|M.abscessus_ATCC_1997 DFADQILADTDGAGVDVVLNSLTSEGFIEATLRATAKNGRFAEIAKRDIW MSMEG_0408|M.smegmatis_MC2_155 DFADQILADTNGAGVDVVLNSLTSAGFVEATLKATAQGGRFAEIAKRDIW Mvan_1003|M.vanbaalenii_PYR-1 DFADQILADTDGAGVDVVLNSLTNDGFVAATVRATARNGRFAEIAKRDIW Mb2971c|M.bovis_AF2122/97 EFEEKFLAVTEGRGVDVVLDSLAGE-FVDASLRLLVRGGRFLEMGKTDIR MLBr_00135|M.leprae_Br4923 EFEEKFLAVTDGRGVDVVLDSLAGD-FVDASLRLLVRGGRFLEMGKTDIR MUL_2005|M.ulcerans_Agy99 DFEEKFLAVTDGRGVDVVLDSLAGD-FVDASLRLLVRGGRFLEMGKTDIR MMAR_3099|M.marinum_M EFAEKFFAATRGRGVDVVLNSLAGE-FVDASLRLLAPGGRFIEMGKTDIR MAV_3108|M.avium_104 DFEQKFGAAPGG--MDVVLNSLAGE-FNDASLRLLGPGGRFIEMGKTDLR Rv2048c|M.tuberculosis_H37Rv EFEDKFRAATGGRGFDVVLDSLAGE-FVDASLRLVAPGGVFLEMGKTDIR TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK TVEQMAAARPDLAYEIVALDTVMFTEPDRIRDLLTEVSAGLRDGAWTPLP MAB_0939|M.abscessus_ATCC_1997 TTEQMAQSRPDIAYEIVALDTVMFQEPDRIRVLLTEVSEGLAKGEWTPLP MSMEG_0408|M.smegmatis_MC2_155 SHEQMAEARPDIAYEIVALDTVMFTEPDRIRDLLTEVSDGMARGEWTPLP Mvan_1003|M.vanbaalenii_PYR-1 SPEQMAAARPDIDYEVLALDAVMQQDPDRIQLLLADLADSLARGETAPLP Mb2971c|M.bovis_AF2122/97 DAQEIAANYPGVQYRAFDLSEAG---PARMQEMLAEVRELFDTRELHRLP MLBr_00135|M.leprae_Br4923 DAQEIAANYPGVQYRAFDLSEAG---PVRMQEMLCEVRELFDTQVLHRLP MUL_2005|M.ulcerans_Agy99 DADKIAANYPGVWYRAFDLSEAG---PVRMQEMLAEVRELFDTAVLHRLP MMAR_3099|M.marinum_M DPQQIAVEYPGVIYEAFDLIEAG---PARIQPMLGQLHTLFEASALESLP MAV_3108|M.avium_104 DPDVVARAHPGVRYRAFDLMEAG---PDRIAAMLAEVMELFAAGALTPLP Rv2048c|M.tuberculosis_H37Rv DPGVIAQQYPGVRYRAFDLFEPG---PDRIAQILAELATLFGDGVLRPLP TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK AEVYPLTEARAAFRRMQQARHIGKIVVQIPNPLQP-QPDRSYLITGGLGA MAB_0939|M.abscessus_ATCC_1997 AEIYPLTEARTAFRRMQQARHIGKIVCQMPNPLAP-RPDRTYLITGGLGA MSMEG_0408|M.smegmatis_MC2_155 AEIYPITEARSAFRRMQQARHIGKIVLQVPKPLQP-QQDRSYLITGGLGA Mvan_1003|M.vanbaalenii_PYR-1 FEAYPLAEATTAFRRMQQARHTGKIILQMPKPLQP-HGDRSYLITGGLGA Mb2971c|M.bovis_AF2122/97 VTTWDVRCAPAAFRFMSQARHIGKVVLTMPSALADRLADGTVVITGATGA MLBr_00135|M.leprae_Br4923 VTSWDVRCAPAAFRFMSQARHIGKVVLTMPSALADGLAEGTVLITGASGA MUL_2005|M.ulcerans_Agy99 VTTWDVRCAPAAFRFMSQARHIGKVVLTMPSALADGLADATVLITGATGA MMAR_3099|M.marinum_M TRTWDARCAPAAYRFVSQARQIGKVVLTMPTQISDAVAAGTVLITGGTGM MAV_3108|M.avium_104 VKAFDARCAADAYRFVSAARHIGKVVLTMPDGPAG-LSGGTALITGATGM Rv2048c|M.tuberculosis_H37Rv VTTFDVRCAPAALRYLSQARHTGKVVMLMP----GSWAAGTVLITGGTGM TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK IG-LHTAGYLAQLGAGDIVLTSRRAPDAAAQQAIADIADRTKARLHVFTA MAB_0939|M.abscessus_ATCC_1997 IG-LHTAAYLAQLGAGDIVLTSRRAPDTDAQRVIGEITERSKTRIHVFTA MSMEG_0408|M.smegmatis_MC2_155 IG-LHTAAYLAQLGAGDIVLTSRRDPDESAQRAIDEITERHKCRIHTYAA Mvan_1003|M.vanbaalenii_PYR-1 LG-LHAAAYLAQLGAGDIVLTGRRMPDAATERAISEIAERYHCRIHTFAA Mb2971c|M.bovis_AF2122/97 VGGVLARHLVGAYGVRHLVLASRRGDRAEGAAELAADLTEAGAKGQVVAC MLBr_00135|M.leprae_Br4923 IGGVLARHMVSAYGVRHLVLASRRGDRAEGAVELAAELVGAGAKIQVVAC MUL_2005|M.ulcerans_Agy99 VGAVLARHMLDGYGVRHLVLASRRGDRAEGAAELAAELSEAGANVQVVAC MMAR_3099|M.marinum_M VASVLARHLVSSYGVKHVVLASRRADATAGVAELVADLAAAGAAVAVVAC MAV_3108|M.avium_104 AGAALARHLVARHRVPHLMLVGRRGEAAPGMAELAAELRGAGASVSVLSC Rv2048c|M.tuberculosis_H37Rv AGSAVARHVVARHGVRNLVLVSRRGPDAPGAAELVAELAAAGAQVQVVAC TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK DVGVEADVAALLERIRAELPPLAGVAHLAGVLDDALLSQQSVERFRTALA MAB_0939|M.abscessus_ATCC_1997 DVGAESEVAGLLERIRAELPPLAGVAHLAGVLDDALLGQQSVERFRTTLA MSMEG_0408|M.smegmatis_MC2_155 DVGDEAQVADLLARIRAELPPLAGIAHLAGVLDDALLSAQNPERFRTTLA Mvan_1003|M.vanbaalenii_PYR-1 DVGDESAVRDLLERIRTELPPLAGVAHLAGVLDDALLPQQSPERFRTTLA Mb2971c|M.bovis_AF2122/97 DVADRAAVAGLFAQLSREYPPVRGVIHAAGVLDDAVITSLTPDRIDTVLR MLBr_00135|M.leprae_Br4923 DVADNDAVRGLFAQLSREFPPVRGVIHAAGVLDDGAITSLTPDRVDTVLR MUL_2005|M.ulcerans_Agy99 DVADRDAVEAMLARLSGEYPPVRGVIHAAGVLDDAVISSLTPERIDTVLR MMAR_3099|M.marinum_M DVADRAAVTRLLDHVSTCHPPLTGVIHAAGTLDDAVIASLTPDRVDAVLR MAV_3108|M.avium_104 DVGDRDAVAAMLAQVPARYP-LRSVFHAAGVLDDAVIASLTPARIDTVLR Rv2048c|M.tuberculosis_H37Rv DAADRAALAKVIADIPVQHP-LSGVIHTAGALDDAVVMSLTPDRVDVVLR TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK PKAFGAVHLDRLTRVDDLDFFLVSSSVSSLFGSPGQSNYATANAFLDGLV MAB_0939|M.abscessus_ATCC_1997 PKAFGAEYLDRLTKGDDLDFFIVSSSVSSLFGSPGQSNYATANALLDGLI MSMEG_0408|M.smegmatis_MC2_155 PKAYGASHLDRLTRDDDLDFFIVSSSVSSLFGSPGQANYATANAMLDGLV Mvan_1003|M.vanbaalenii_PYR-1 PKAFGAWHLHRLTRDTELEFFIVYSSGSSVLGSPGQANYATANAVLDGLV Mb2971c|M.bovis_AF2122/97 AKVDAAWNLHQATSDLDLSMFVLCSSIAATVGSPGQGNYSAANAFLDGLA MLBr_00135|M.leprae_Br4923 AKVDAAWNLHEATRDLDLLMFVLCSSIAATVGSPGQGNYSAANAFLDGLA MUL_2005|M.ulcerans_Agy99 AKVDAAWNLHEATLDLDLSMFVLCSSIAATVGSPGQGNYSAANSFLDGLA MMAR_3099|M.marinum_M AKVDGAWNLHEATRHLGLSMFVLCSSIAATVGSSGQANYAAGNAFLDGLA MAV_3108|M.avium_104 AKVDGAWNLHELTKDLDLSAFVVFSSMAGIVGAPGQGNYAAANSFLDALA Rv2048c|M.tuberculosis_H37Rv SKVDAAWHLHELTRDLDVSAFVMFSSMAGLVGSSGQANYAAANSFLDALA TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK AQRRAQGLPATGVNFGPWARGGMASSEAAAAN---ISAQGLIPLEPSAAL MAB_0939|M.abscessus_ATCC_1997 AQRRAQGLPATGINFGPWGQGGMASSEAATAN---ISAQGLIPLDPSAAL MSMEG_0408|M.smegmatis_MC2_155 AKRRAQGLVATGINFGPWGQGGMASSEAATAN---ITAQGLIPLDPSAAL Mvan_1003|M.vanbaalenii_PYR-1 AHRKARGLPATGVNWGPWAQGGMATSDAARAN---LGAQGLIPLEPTAAL Mb2971c|M.bovis_AF2122/97 AHRQAAGLAGISLAWGLWEQPGGMTAHLSSRDLARMSRSGLAPMSPAEAV MLBr_00135|M.leprae_Br4923 AYRQAAGLAGTSLAWGLWEQPGGMNAHLSSRDLARISRSGLAPMNPAQAL MUL_2005|M.ulcerans_Agy99 AHRQAAGLAGISVAWGLWEQSGGMAAHLSSRDLARMSRSGLAPMNPEQAV MMAR_3099|M.marinum_M AYRRAGGLPGMSLGWGLWEQSSTMTAHLSDRDMARIRRIGLAAISPEQAM MAV_3108|M.avium_104 IHRHAHGLPALSVAWGMWEEPSAMTAHLEERDKARMSRAGLSALSTRQAL Rv2048c|M.tuberculosis_H37Rv AHRRAHGLPAISLGWGLWDQASAMTGGLATVDFKRFARDGIVAMSSADAL TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK TAMAEVVANGTAQATVLKAN-WQRAAKVLGSSRPPILDLVLPSAVG---- MAB_0939|M.abscessus_ATCC_1997 AALAEVVANGTGQATILKAN-WQRAAKVLGSSRPPILDLVLPSAVG---- MSMEG_0408|M.smegmatis_MC2_155 HALAEVIANGSGQATVLKAN-WQRAAKVLGSARPPILDLVLPSAAG---- Mvan_1003|M.vanbaalenii_PYR-1 NALGEIVAHGIASAVVLKAN-WQRAAKLLGATRPPILDHVLPSAVA---- Mb2971c|M.bovis_AF2122/97 ELFDAALAIDHPLAVATLLDRAALDARAQAGALPALFSGLARRPRRRQID MLBr_00135|M.leprae_Br4923 ELFDAALVIDHPFMVTALLDRAALDAQAQAGALPPLFSRLVRRSRRRQIE MUL_2005|M.ulcerans_Agy99 GLLDAVLAINHPLMVATLLDRPALEARAQAGGLPPLFAGVVRRPRRRQIE MMAR_3099|M.marinum_M QLFDAALAVGQPTVLAAHLDHAVLANHTLSSTLPPLFSTLIKRPLRRLVD MAV_3108|M.avium_104 DLLDDALLGEQPLVVGTRLDRAALAQHRAA--LPPLLSELAGRPARRMLE Rv2048c|M.tuberculosis_H37Rv QLFDTAMIVDEPFMLPAHIDFAALKVKFDGGTLPPMFVDLINAPTRRQVD TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK ----EITGDSELLKQLQEIPVPQRAGFVTEFLQKEVQNFLRLAQPP--AA MAB_0939|M.abscessus_ATCC_1997 ----EVTGDSELLKQLMEIPVPQRAGFVTEFLQREVQNFLRLAQPP--AA MSMEG_0408|M.smegmatis_MC2_155 ----EATGDSELLKQLMEIPIPQRAGFVTEFLQREVQNFLRLASPP--AA Mvan_1003|M.vanbaalenii_PYR-1 ----AGPGDSALLKQLQDVPEAQRGSFVTEHLQRELQQILGLAQPP--AA Mb2971c|M.bovis_AF2122/97 DTGDATSSKSALAQRLHGLAADEQLELLVGLVCLQAAAVLGRPSAEDVDP MLBr_00135|M.leprae_Br4923 DPGDATQSKLALVQRLQGLAANRQLELLVGVVCLQAAAVLGRPSPEDIDP MUL_2005|M.ulcerans_Agy99 DTGDAAQSKSALAERLNGLSAGERQDALVGLVCLQAAAVLGRPSPEDIDP MMAR_3099|M.marinum_M N--DTPSSTAGFAQRLYGLKPEKQQDLLVDLVCTQAAAVLGHPSATDLNP MAV_3108|M.avium_104 HT--DMVSLTGLRARLAGMNPEQRQAELVELVCGNAAAVLG-HSTADVDP Rv2048c|M.tuberculosis_H37Rv DSLAAAKSKSALLQRLEGLPEDEQHAVLLDLVRSHIATVLGSASPEAIDP TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK TSRFLDLGTDSLMAIELRNRLHSQFGGAFTINATAVFDYPTIGGLAEYLV MAB_0939|M.abscessus_ATCC_1997 TSRFLDLGTDSLMAIELRNRLHSQFGGKFTINATAVFDYPTIGGLAEYLV MSMEG_0408|M.smegmatis_MC2_155 SSRFLDLGTDSLMAIELRNRLHSQFGGKFTINATAVFDYPTIGGLAEYLV Mvan_1003|M.vanbaalenii_PYR-1 TGRFLELGMDSLMAVELRNRLVGQFGSGFTITATAVFDYPTIGALAEYLA Mb2971c|M.bovis_AF2122/97 DTEFGDLGFDSLTAVELRNRLKTATG--LTLPPTVIFDHPTPTAVAEYVA MLBr_00135|M.leprae_Br4923 NTKFQDLGFDSLTAVELRNRLKSATG--LTLPPTVIFDHPTPTAVAEYVA MUL_2005|M.ulcerans_Agy99 EAGFQDLGFDSLTAVELRNRFKSATG--LTLPPTVIFDHPTPTAIAEYVG MMAR_3099|M.marinum_M ASTFQNMGFDSLTAVELRNRLKTVTG--LGLSPTLVFDHPTPTALAGLIA MAV_3108|M.avium_104 GDAFSDLGFDSLTAVELRNRLKIATG--LTLSPTVIFDHPTPAALAEHLG Rv2048c|M.tuberculosis_H37Rv DRAFQELGFDSLTAVEMRNRLKSATG--LALSPTLIFDYPNSAALAGYMR TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK AQLPDAET----------------------------------PQAAP--- MAB_0939|M.abscessus_ATCC_1997 GQLPDADA----------------------------------ESAEAPPA MSMEG_0408|M.smegmatis_MC2_155 GQLPDAEA----------------------------------PETA---- Mvan_1003|M.vanbaalenii_PYR-1 AQTPESTE----------------------------------EGTEMKTA Mb2971c|M.bovis_AF2122/97 QQMSGSRP---------------------------------TESGDPTSQ MLBr_00135|M.leprae_Br4923 QQMLKSRP---------------------------------AESGDETSQ MUL_2005|M.ulcerans_Agy99 RQIPDSQA---------------------------------TQAEEE--K MMAR_3099|M.marinum_M ELIGIAAKGLSPLEEALNNVEE---------------TLPAIEAGDKHRV MAV_3108|M.avium_104 GQLTSAGPTPAAPAETAAPPDRSSRIDEVVSELQTLLTQPGLSPGDRAQL Rv2048c|M.tuberculosis_H37Rv RELLGSSPQDTSAVAAGEAELQR---------------IVASIPVKRLRQ TH_4458|M.thermoresistible__bu -------------------------------------------------- Mflv_0405|M.gilvum_PYR-GCK ----QSESEPGPDVTE--------------------------------- MAB_0939|M.abscessus_ATCC_1997 VESAEAESGAGPAAASDAVSELKE------------------------- MSMEG_0408|M.smegmatis_MC2_155 ------------------------------------------------- Mvan_1003|M.vanbaalenii_PYR-1 DPDGQPATVGHADVVLQTS------------------------------ Mb2971c|M.bovis_AF2122/97 VVEPAAAEVSVHA------------------------------------ MLBr_00135|M.leprae_Br4923 AVEPKVEEVSVHA------------------------------------ MUL_2005|M.ulcerans_Agy99 LPESDGEMVSVTA------------------------------------ MMAR_3099|M.marinum_M ADRLRALLSTITDEEHRLDERIQAASTLDEVLLLVDSELANLEKGPGL- MAV_3108|M.avium_104 VTRLQSLLSTPPQPSG--HPEFPEDAFDDDIATATDSQLFAILDDEAGP Rv2048c|M.tuberculosis_H37Rv AGVLDLLLALANETETSGQDPALAPTAEQEIADMDLDDLVNAAFRNDDE TH_4458|M.thermoresistible__bu -------------------------------------------------