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DFGILPPEINSARMYSGPGSSPLLTVASAWSGLAAELSATANDYETVISGLQSQGWVGPSSEAMANSIWP YVAWLRATAAATEQSASKARIAASAYEAAFAATVPPPQIAANRAELTGLISTNVVGQNSAAIAAAEAQYG EMWSQDAATMYAYAASCATATSLTPFVSPPQTTNPTAAATQAGTLSRAAATTTGTAQSTLSRLISEVPGV LQALTSPLASAASSTAGPIERFLEWYAPFANFFYDTLGLPFFGAGITSFFAATAKTAGAIGPAAAAPAAT VAATGAAEAVGAGPVSASLAQASTVGKLSVPHTWEGATPATSPTTASKFISDVIEPESVEAGGNVIGGVP MPGPGKGSAGAGPRYGVRLTVMPHPPSAG*
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. marinum M | MMAR_1094 | - | - | 100% (380) | PPE family protein |
M. marinum M | MMAR_2516 | - | e-107 | 50.26% (392) | PPE family protein |
M. marinum M | MMAR_1904 | - | 1e-95 | 46.12% (399) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb1731c | PPE22 | 1e-121 | 55.32% (385) | PPE family protein |
M. gilvum PYR-GCK | Mflv_0325 | - | 1e-31 | 29.52% (376) | PPE protein |
M. tuberculosis H37Rv | Rv1705c | PPE22 | 1e-121 | 55.06% (385) | PPE family protein |
M. leprae Br4923 | MLBr_01182 | - | 1e-52 | 34.69% (418) | PPE-family protein |
M. abscessus ATCC 19977 | MAB_4783 | - | 4e-32 | 29.35% (402) | PPE family protein |
M. avium 104 | MAV_2926 | - | 1e-89 | 44.72% (407) | PPE family protein |
M. smegmatis MC2 155 | MSMEG_0619 | - | 5e-30 | 29.51% (366) | PPE family protein |
M. thermoresistible (build 8) | TH_3113 | - | 1e-32 | 29.15% (398) | PUTATIVE PPE protein |
M. ulcerans Agy99 | MUL_5078 | - | 0.0 | 98.16% (380) | PPE family protein |
M. vanbaalenii PYR-1 | Mvan_0415 | - | 3e-33 | 34.31% (274) | PPE protein |
CLUSTAL 2.0.9 multiple sequence alignment MMAR_1094|M.marinum_M -------------MDFGILPPEINSARMYSGPGSSPLLTVASAWSGLAAE MUL_5078|M.ulcerans_Agy99 -------------MDFRILPPEINSARMYSGPGSSPLLTVASAWSGLAAE Mb1731c|M.bovis_AF2122/97 -------------MDFGALPPEVNSGRMYCGPGSAPMVAAASAWNGLAAE Rv1705c|M.tuberculosis_H37Rv -------------MDFGALPPEVNSGRMYCGPGSAPMVAAASAWNGLAAE MAV_2926|M.avium_104 -----------MMLDYGTFPPEFNSARIYSGPGSGSLVAAASAWSSLAAE MLBr_01182|M.leprae_Br4923 ------------MFDFAALSPETNSTRMYLGPGSSPILTAAAAWVVLAKE Mflv_0325|M.gilvum_PYR-GCK MTSPVASLAPVTSPVWMALPPEVHSTMLSSGPGPGSLLAAGVAWQSLSAE Mvan_0415|M.vanbaalenii_PYR-1 ----------MSSPVWMALPPEVHSALLSSGPGPGSMLAAAATWQSLSAE MSMEG_0619|M.smegmatis_MC2_155 ----------MTAPIWMALPPEVHSSLLSSGPGPGSLLAAAGAWQSLSAE MAB_4783|M.abscessus_ATCC_1997 ----------MTAPVWMAAPPEVHSALLSSGPGPGSLFAAADAWRSLSTE TH_3113|M.thermoresistible__bu ----------------MALPPEVHSTLLRTGPGPGALSAAADAWRMLSDE .** :* : ***...: :.. :* *: * MMAR_1094|M.marinum_M LSATANDYETVISGLQSQGWVGPSSEAMANSIWPYVAWLRATAAATEQSA MUL_5078|M.ulcerans_Agy99 LSATANDYETVISGLQSQGWVGPSSEAMANSIWPYVAWLRATAAATEQSA Mb1731c|M.bovis_AF2122/97 LSVAAVGYERVITTLQTEEWLGPASTLMVEAVAPYVAWMRATAIQAEQAA Rv1705c|M.tuberculosis_H37Rv LSVAAVGYERVITTLQTEEWLGPASTLMVEAVAPYVAWMRATAIQAEQAA MAV_2926|M.avium_104 LNAAALSYDKVVTALASEEWLGSASASMASAVAPYVGWMSTTAAQAEEAA MLBr_01182|M.leprae_Br4923 LTAAAQGLQSAVEALLTT-FEGESAAALAERVTPYEKWLTQNAASAELTA Mflv_0325|M.gilvum_PYR-GCK YASAAAELTSILAGVQSGAWEGPSSQQYVAAHTPYLAWLAQQSAVSAATA Mvan_0415|M.vanbaalenii_PYR-1 YAAAAAELSSILADVQAGAWEGPSSEQYVAAHTPYLAWLAQQSAAGAAAA MSMEG_0619|M.smegmatis_MC2_155 YAAAAAELTSVLSAVQAGSWEGPSSEQYVAAHAPYLQWLAQQSANSAAAA MAB_4783|M.abscessus_ATCC_1997 YSSAANELTTTLGSVRAGVWDGASAEQYQTAHVPYLSWLHETSAVSAGVA TH_3113|M.thermoresistible__bu YRAAAVELAAVVSQTCATAWEGVGADAYAAAHGPYLFWLTDTAAAAAAAG :* : : : * .: ** *: : . MMAR_1094|M.marinum_M SKARIAASAYEAAFAATVPPPQIAANRAELTGLISTNVVGQNSAAIAAAE MUL_5078|M.ulcerans_Agy99 SKARIAASAYEAAFAATVPPPQIAANRAELTGLISTNVVGQNSAAIAAAE Mb1731c|M.bovis_AF2122/97 SQARAAAAAYETAFAAIVPPPLIAANRARLTSLVTHNVFGQNTASIAATE Rv1705c|M.tuberculosis_H37Rv SQARAAAAAYETAFAAIVPPPLIAANRARLTSLVTHNVFGQNTASIAATE MAV_2926|M.avium_104 SQARAAAAAYEAALAASVPPPLIAANRMQVSQLQATNVLGQNTPLIAQLE MLBr_01182|M.leprae_Br4923 TQLTVAANAYETAFTMTVPPLMVFVNRAQACLLIMSNIFGQNSTAIAEKE Mflv_0325|M.gilvum_PYR-GCK VQHDTAAAAYTTALATMPTLPELALNHTTHAVLVGTNFLGINTIPIALNE Mvan_0415|M.vanbaalenii_PYR-1 AQHEAAAAAYSTALATMPTLPELALNHTTHAVLVATNFLGINTIPIAMTE MSMEG_0619|M.smegmatis_MC2_155 VQHETAAAAYSTALATMPTMAELALNHTMHGVLVATNFFGINTIPIALNE MAB_4783|M.abscessus_ATCC_1997 AQTETAATAYSEALATMPTLGELAANHATHGALVATNFFGINTIPIAVNE TH_3113|M.thermoresistible__bu AQLEAAAAAHASALAAMPTMAELTANRTTHAALVATNFFGVNTIPIAVNE : ** *: *:: . : *: * *..* *: ** * MMAR_1094|M.marinum_M AQYGEMWSQDAATMYAYAASCATATSLTPFVSPP---------------- MUL_5078|M.ulcerans_Agy99 AQYGEMWSQDAATMYAYAASCATATSVTPFVSPP---------------- Mb1731c|M.bovis_AF2122/97 AQYAEMWAQDAMAMYGYAGSSATATKVTPFAPPP---------------- Rv1705c|M.tuberculosis_H37Rv AQYAEMWAQDAMAMYGYAGSSATATKVTPFAPPP---------------- MAV_2926|M.avium_104 AQYGEYWAQDAAAMYSYAGQSASASKVTPFQKAP---------------- MLBr_01182|M.leprae_Br4923 AEYTEMWIQDAAAMTSYQASVLEAVGATKAFTAPPLGVNEVGLAQEVVEE Mflv_0325|M.gilvum_PYR-GCK ADYVRMWIQAATTMATYQSVSGAALAATPTSAPAPSVLLP--------GV Mvan_0415|M.vanbaalenii_PYR-1 ADYVRMWIQAATTMATYQAVSGAALAATPTATPAPFVLAP--------GV MSMEG_0619|M.smegmatis_MC2_155 ADYVRMWIQAATTMSTYQAVSGAAVAAAPVSAPAPFLLKP--------GV MAB_4783|M.abscessus_ATCC_1997 ADYIRMWIQAATVMSTYQAVSESSVSAAPPTSPAPPVLSP--------DS TH_3113|M.thermoresistible__bu ADYARMWIQAATTMATYEAVASAAVSATPRTVAPPPILGA--------GT *:* . * * * .* * . : : .. MMAR_1094|M.marinum_M ---QTTNPTAAATQAGTLSRAAATTTGTAQSTLSRLISEVP--------- MUL_5078|M.ulcerans_Agy99 ---QTTSPTAAATQAGTLARAAATTAGTAQSTLSRLISEVP--------- Mb1731c|M.bovis_AF2122/97 ---NTTSPSAAATQLSAVAKAAGTSAGAAQSAIAELIAHLP--------- Rv1705c|M.tuberculosis_H37Rv ---NTTSPSAAATQLSAVAKAAGTSAGAAQSAIAELIAHLP--------- MAV_2926|M.avium_104 ---QVTNPSGQAAQSAAVSTATANSTSTNTTKALQSLAQPA--------- MLBr_01182|M.leprae_Br4923 VVEEVVEEVVEAEQAISQAALDQAVNEGMEATVVPQVDQQV--------- Mflv_0325|M.gilvum_PYR-GCK GEAGRAAADMSAFAAQPMAAQAGAAFD-VSNIIADIIRLYG------EVL Mvan_0415|M.vanbaalenii_PYR-1 GEAGRAAADVTAFAAQAQAAEAGSALD-LSNIIADLIRAYG------ELL MSMEG_0619|M.smegmatis_MC2_155 GEAGSASASVQQMSAQATAAESGSSLD-LSSIISDLLNQYL------QGV MAB_4783|M.abscessus_ATCC_1997 GAAART-------AAQDATKPPPIVPD-PNDPIEMLLKNS-------QHF TH_3113|M.thermoresistible__bu GESATAAITGAHVTAELRAAESRTLLDEINELIDRLFAPLFPPGFADALP . : . MMAR_1094|M.marinum_M -----------------------GVLQALTSPLASAASSTAGP------- MUL_5078|M.ulcerans_Agy99 -----------------------GVLQALTSPLASAASSTAGP------- Mb1731c|M.bovis_AF2122/97 -----------------------NTLLGLTSPLSSALTAAATPGW----- Rv1705c|M.tuberculosis_H37Rv -----------------------NTLLGLTSPLSSALTAAATPGW----- MAV_2926|M.avium_104 -----------------------SSSTTATKAATTAASTTSTDPLSEIWF MLBr_01182|M.leprae_Br4923 -----------------------NVDVATPQTAVPDSSSAAAPQLWG--- Mflv_0325|M.gilvum_PYR-GCK RFLFEPIFNFLR-------DPIGNTFALITDFLTNPVQALITWGPFLLAV Mvan_0415|M.vanbaalenii_PYR-1 RFLFEPIFDFLR-------DPLGNTIKLITDFLTNPAQALITWGPFLAAV MSMEG_0619|M.smegmatis_MC2_155 PGG-QAILDFLK-------DPLGNLGRLLTDFMTNPAGALATWWPFLFGV MAB_4783|M.abscessus_ATCC_1997 LGMYRALKGLIT-------DPVGTIVRIIIDFSTNPAAAIVTWTPLFYVF TH_3113|M.thermoresistible__bu DGLLGTLLAPLLPGATGDGPPMATIMSFLLMGLSNPAYLFPVLVYLLFTG MMAR_1094|M.marinum_M -----------IERFLEWYAPFANFFYDTLGLPFFGAGITS--------- MUL_5078|M.ulcerans_Agy99 -----------IERFLEWYAPFANFFYDTLGLPFFGAGITS--------- Mb1731c|M.bovis_AF2122/97 -----------LEWFINWYLPISQLFYNTVGLPYFAIGIGN--------- Rv1705c|M.tuberculosis_H37Rv -----------LEWFINWYLPISQLFYNTVGLPYFAIGIGN--------- MAV_2926|M.avium_104 LLTGQTTLPTSLGSAVNGYSPFASLFYNTEGLPYFSTGMAN--------- MLBr_01182|M.leprae_Br4923 ----------GFAQHLSPINDTLSMINNHAGMANAGLSLVN--------- Mflv_0325|M.gilvum_PYR-GCK VYQA----VSWVGASILYPSLFLLPLLATT--LAIVAGVGQ---HLLSLL Mvan_0415|M.vanbaalenii_PYR-1 AYQA----VSWVGASILYPSLLLLPLVATT--LAIVLGVGA---YLLENL MSMEG_0619|M.smegmatis_MC2_155 AYQVFFNLVGWPTWGMIFASPFLIPALAALGITGLVLLIDH---VLNNPV MAB_4783|M.abscessus_ATCC_1997 AYAA-----TFAVMGTPIYAAIMGPAAGISIPLAITLAS------LSQMP TH_3113|M.thermoresistible__bu VVHTTVAVSGMLAQLVPLMPALLPVAVAALGGLAGVWAGLSGLAGLAGLT MMAR_1094|M.marinum_M --------------------FFAATAKTAGAIGPAAAAPAATVAATG--- MUL_5078|M.ulcerans_Agy99 --------------------LFAATAKTAGAIGPAAAAPAATVAATG--- Mb1731c|M.bovis_AF2122/97 --------------------SLITSWRALGWIGPEAAEAAAAAPAAV--- Rv1705c|M.tuberculosis_H37Rv --------------------SLITSWRALGWIGPEAAEAAAAAPAAV--- MAV_2926|M.avium_104 --------------------TFTQIAKSVGAIGGAAPAAAKALPGLGGLG MLBr_01182|M.leprae_Br4923 --------------------GMGSAMKSLAPTTTKAAESAFKAMGSAVQS Mflv_0325|M.gilvum_PYR-GCK NTPPAEEAAEEPAPAQSAPSRPDQQSFPATMSAPPPPSGAPIAANTVSAG Mvan_0415|M.vanbaalenii_PYR-1 PAPAEDAPAEEPAASSPAPTRADQPSPAIAVSAPPPPSSAAATVGTVATG MSMEG_0619|M.smegmatis_MC2_155 DVPAEDEAPQEVAAAP----RTDQP-LAVGISPAGVPGSAATAAAPAPAP MAB_4783|M.abscessus_ATCC_1997 EAPPVDAPAETVPARIDQPHAVAMGGAPAPTASTAAP--TPTTTSPATPG TH_3113|M.thermoresistible__bu AVPAADGGASAAPVPAGGPSLPSGSSAPPAPTGSAAPTTGTAPGGAGSPP . . MMAR_1094|M.marinum_M ------------AAEAVGAGPVSASLAQASTVGKLSVPHTWEGATPATSP MUL_5078|M.ulcerans_Agy99 ------------AAEAVGAGPVSASLAQASTVGKLSVPHTWEGATPATSP Mb1731c|M.bovis_AF2122/97 ------------GAAVGGTGPVSAGLGNAATIGKLSVPPNWAGASPSLAP Rv1705c|M.tuberculosis_H37Rv ------------GAAVGGTGPVSAGLGNAATIGKLSLPPNWAGASPSLAP MAV_2926|M.avium_104 GML---------GGGAAAAHPVAALGGAGSIGGKLSVPVAWSGAPATPAL MLBr_01182|M.leprae_Br4923 TGRG--------LLGSSSGGHVTAQLGRAASIGSLRVPQTWTTASQPVTA Mflv_0325|M.gilvum_PYR-GCK SP-----PAPGAPAAAAATFVPYVVAGRDPYEGFSPTVRDSTGAKAPAGT Mvan_0415|M.vanbaalenii_PYR-1 TA-----PAPGAPAAATASFVPYAVAGRDPGTGFSPTVRDSTSAKAPASG MSMEG_0619|M.smegmatis_MC2_155 AG-----TTVAAPAPAAATFVPYAVANRDPGEGFTPTLGNKSQVAAPASG MAB_4783|M.abscessus_ATCC_1997 SA-----PAP-TPPPAGAEGLGYAVRGDGPGFGFGPTIGASTGATAHAPS TH_3113|M.thermoresistible__bu PAGHSVPPAPHSAPPVGTSGPPYLIAAQ-PAPGVARRSAGARRAASIVEP . * . MMAR_1094|M.marinum_M TTASK---FISDVIEPESVEAG-GNVIGG--------------------- MUL_5078|M.ulcerans_Agy99 TTASK---FISDVIEPESVEAG-GNVIGG--------------------- Mb1731c|M.bovis_AF2122/97 TVGSASAPLVSDIVEQPEAGAA-GNLLGG--------------------- Rv1705c|M.tuberculosis_H37Rv TVGSASAPLVSDIVEQPEAGAA-GNLLGG--------------------- MAV_2926|M.avium_104 GHAIP----VSSISAAPEAAGGPGNLLGG--------------------- MLBr_01182|M.leprae_Br4923 ATRALSPARVAVATESESAPLLGGGLPMA--------------------- Mflv_0325|M.gilvum_PYR-GCK IPAAASGIAASAAERRKRRRRQKEEIKGRGYADAYADYEELPDDGPPEQP Mvan_0415|M.vanbaalenii_PYR-1 IPAAASGVAASAAERRKRRRRQKDEIAGRAYADAYADYEPEPDDEPPVRQ MSMEG_0619|M.smegmatis_MC2_155 VPAAASGVAASLASRRKRRRKKGAQIEERGYADAYMDYEE-PDEDPAPQP MAB_4783|M.abscessus_ATCC_1997 SAVSAAAALACNPATGKSRRRRRRTIDDRGYRHEYATMDDHTPTGP--QD TH_3113|M.thermoresistible__bu AGSAAAAAAARESAPIRRRRGQKDGLHGHRHEHQQPASMS---------- : MMAR_1094|M.marinum_M ---VPMPGPGKG--SAGAGPRYGVRLTVMPHPPSAG-------------- MUL_5078|M.ulcerans_Agy99 ---VPMPGPGEG--SAGAGPRYGVRLTVMPHPPSAG-------------- Mb1731c|M.bovis_AF2122/97 ---MPLAGSGTG--TGGAGPRYGFRVTVMSRPPFAG-------------- Rv1705c|M.tuberculosis_H37Rv ---MPLAGSGTG--TGGAGPRYGFRVTVMSRPPFAG-------------- MAV_2926|M.avium_104 ---MPLAGAGAGG-HGAAGPKYGFRPTVMARPPFAG-------------- MLBr_01182|M.leprae_Br4923 ---PMVPGGGSGTGGVNTALRLQPRAFVMPRNPAAG-------------- Mflv_0325|M.gilvum_PYR-GCK APRVTASTRGAGPMGFAGTVSRG-DEQAGGLTTLAGDSFGGGPREPMLPG Mvan_0415|M.vanbaalenii_PYR-1 EPRIAATERGAGPMGFAGTVSRD-AAQAGGLTTLPGDPFGGGPKAPMLPG MSMEG_0619|M.smegmatis_MC2_155 EPRVRASERGSDAMGFTGTVTRH-DVTAAGLTTLTGDTFDDRPVTPMLPG MAB_4783|M.abscessus_ATCC_1997 PVTAVASGTGAGRLGFAGVHTATTAVEATGLSTLDGDAEN--RTIPMLPG TH_3113|M.thermoresistible__bu -AATAPSAAGIRVLGGAGRISRT-RGSVPHAEITPGDPTE--PSSPTDRA . * . * MMAR_1094|M.marinum_M --------------------------- MUL_5078|M.ulcerans_Agy99 --------------------------- Mb1731c|M.bovis_AF2122/97 --------------------------- Rv1705c|M.tuberculosis_H37Rv --------------------------- MAV_2926|M.avium_104 --------------------------- MLBr_01182|M.leprae_Br4923 --------------------------- Mflv_0325|M.gilvum_PYR-GCK TWDPDATDDRHTDGRDGHDGHDGKEKP Mvan_0415|M.vanbaalenii_PYR-1 TWDPDTEPD------ERHNHHDGKDSQ MSMEG_0619|M.smegmatis_MC2_155 TWDGDENPAP------SPDDPEGGPRR MAB_4783|M.abscessus_ATCC_1997 TWDVTDDDR------------------ TH_3113|M.thermoresistible__bu HRPAEPN--------------------