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VDVSDHPSAGVGASNAYQGEGGKDHPTIQLPPVPHQPPQLGEPPVAGGSDAPTRAFAGFRTERRSAARAE GAEAPDVAQWESGPDTGPVAGLPRVDPTAYGAYYNGPPEPPAEPQYRPESVPQTPYPELSTSMLLRPVKS PPTEGWRRLVYVLSGQLINLGESPRATRYNNLVAQINRPMRGCYRIALVSLKGGVGKTTITATLGSTFAS VRGDRVVAVDANPDRGTLSQKVPLETPATVRHLIRDAEGIERYSDVRGYTSQAKNGFEVLASDTDPAASE AFSADDYTRTLDILERFYGLVLTDCGTGLLHSAMSAILAKSDILIVVSSGSIDGARSASATLDWLEAHGY EELVRNSIAVINAVRPRSSKVDMQKVIDHFARRCRAVRLVPFDPHLEEGAEIVLDRMKRETREALAELAA VVAEGFGPDQRRSSPSFG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_0876 | - | - | 100% (438) | hypothetical protein MMAR_0876 |
| M. marinum M | MMAR_5451 | - | 2e-55 | 33.25% (412) | hypothetical protein MMAR_5451 |
| M. marinum M | MMAR_5436 | - | 4e-33 | 28.68% (387) | hypothetical protein MMAR_5436 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0543 | - | 1e-176 | 69.93% (439) | hypothetical protein Mb0543 |
| M. gilvum PYR-GCK | Mflv_0048 | - | 1e-124 | 62.89% (353) | hypothetical protein Mflv_0048 |
| M. tuberculosis H37Rv | Rv0530 | - | 1e-176 | 69.93% (439) | hypothetical protein Rv0530 |
| M. leprae Br4923 | MLBr_00798 | - | 7e-51 | 36.39% (316) | hypothetical protein MLBr_00798 |
| M. abscessus ATCC 19977 | MAB_3972c | - | 1e-135 | 59.03% (432) | hypothetical protein MAB_3972c |
| M. avium 104 | MAV_4615 | - | 1e-166 | 69.18% (438) | hypothetical protein MAV_4615 |
| M. smegmatis MC2 155 | MSMEG_0975 | - | 1e-139 | 60.66% (427) | hypothetical protein MSMEG_0975 |
| M. thermoresistible (build 8) | TH_0884 | - | 1e-126 | 69.68% (310) | conserved hypothetical protein |
| M. ulcerans Agy99 | - | - | - | - | - |
| M. vanbaalenii PYR-1 | Mvan_0870 | - | 1e-121 | 65.67% (335) | hypothetical protein Mvan_0870 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0543|M.bovis_AF2122/97 --------------------------------------------------
Rv0530|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0876|M.marinum_M --------------------------------------------------
MAV_4615|M.avium_104 --------------------------------------------------
MSMEG_0975|M.smegmatis_MC2_155 --------------------------------------------------
TH_0884|M.thermoresistible__bu --------------------------------------------------
Mflv_0048|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0870|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_3972c|M.abscessus_ATCC_199 ----------------------------MSDYPAHRAPDGPSPYAADEAQ
MLBr_00798|M.leprae_Br4923 MTTFRERRTMFDAAVASYQSGDKTSAGAAFARLTVENPDMSDSWLGRLAC
Mb0543|M.bovis_AF2122/97 -----------------------------------------MLVTEHPRT
Rv0530|M.tuberculosis_H37Rv -----------------------------------------MLVTEHPRT
MMAR_0876|M.marinum_M -----------------------------------------MDVSDHPSA
MAV_4615|M.avium_104 -------------------------------------------MSEHPTA
MSMEG_0975|M.smegmatis_MC2_155 --------------------------------------------------
TH_0884|M.thermoresistible__bu --------------------------------------------------
Mflv_0048|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0870|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_3972c|M.abscessus_ATCC_199 GGPTAPPWAAQEPAQPVMYGQSTPQQPHEMTQQFQAVPFQDPFAPQQDIA
MLBr_00798|M.leprae_Br4923 GDHNLDTLAGAHQHSEVLYSETRRVGLKDGDLRAEIAAPMYLTLTTWSRA
Mb0543|M.bovis_AF2122/97 GVGAPDS----GNGGTDHPTVQLPP-------------------------
Rv0530|M.tuberculosis_H37Rv GVGAPDS----GNGGTDHPTVQLPP-------------------------
MMAR_0876|M.marinum_M GVGASNAY--QGEGGKDHPTIQLPP-------------------------
MAV_4615|M.avium_104 GVGAPEE-----------QTTQIPP-------------------------
MSMEG_0975|M.smegmatis_MC2_155 -----------MSASSEHPVPDSVD-------------------------
TH_0884|M.thermoresistible__bu --------------------------------------------------
Mflv_0048|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0870|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_3972c|M.abscessus_ATCC_199 GLGHDPAVPSLNSLGGSFAPLDFTP-------------------------
MLBr_00798|M.leprae_Br4923 TIGLAYASALINAGRYDEASVALDDPVVTEDDDAALARQFVMATLFHQTR
Mb0543|M.bovis_AF2122/97 ----------VPS-------VGAPPAAAGGETPTRSVAGFRTQR------
Rv0530|M.tuberculosis_H37Rv ----------VPS-------VGAPPAAAGGETPTRSVAGFRTQR------
MMAR_0876|M.marinum_M ----------VPHQ---PPQLGEPPVAGGSDAPTRAFAGFRTERRSAARA
MAV_4615|M.avium_104 ----------AAAAGDDKKDAAEPQPEPGGDAPTKAFAGFRTERRVPERE
MSMEG_0975|M.smegmatis_MC2_155 ----------VPAP------EHPAAETPEAPSVFAPVPGFRGQQRFSDPA
TH_0884|M.thermoresistible__bu --------------------------------------------------
Mflv_0048|M.gilvum_PYR-GCK -------------------------------------MSFRAQQRFSD--
Mvan_0870|M.vanbaalenii_PYR-1 ---------------------------------MDAPGSFRAQQRFSD--
MAB_3972c|M.abscessus_ATCC_199 ----------SGSQ------EAGDPTAVGAAGSSGGPGGFRADNRFSDSG
MLBr_00798|M.leprae_Br4923 SWSNVLKVAEVPPQNSNTDDRNELTDAVAALASTAASNLGQFQFALELTE
Mb0543|M.bovis_AF2122/97 -------------------------LDPTAYGAYYSGPDEGPASPAERPP
Rv0530|M.tuberculosis_H37Rv -------------------------LDPTAYGAYYSGPDEGPASPAERPP
MMAR_0876|M.marinum_M EGAEAPDVAQWESGPDTGPVAGLPRVDPTAYGAYYNGPPEPPAEPQYRP-
MAV_4615|M.avium_104 PAPPTAPRPGGMPPWDSTPVTGIPRVDPTAYGAYYAGPDAPPTQIQGPPP
MSMEG_0975|M.smegmatis_MC2_155 QAGVSTPLP---AEWTA---------PTPPHGIPVSAPQTAQTPPQNSHQ
TH_0884|M.thermoresistible__bu --------------------------------------------------
Mflv_0048|M.gilvum_PYR-GCK ---PMAPVP---AEWTA---------PTPPEGVVPVVAAATPSTE-----
Mvan_0870|M.vanbaalenii_PYR-1 ---PMAPVP---AEWTA---------PTPPEGAPPVVTADP---------
MAB_3972c|M.abscessus_ATCC_199 EQ-PAQPTPFTADRWAS---------DTPPSGIPQQAQQPPVGGSRYYTP
MLBr_00798|M.leprae_Br4923 RVSTTNPQVAADVALNRAWCLRELGDDNAARAALTAAPVNDIPTTHNTAE
Mb0543|M.bovis_AF2122/97 Y---------------------RLEPVPHTPYPELATTTLLRPVKPPPSE
Rv0530|M.tuberculosis_H37Rv Y---------------------RLEPVPHTPYPELATTTLLRPVKPPPSE
MMAR_0876|M.marinum_M ------------------------ESVPQTPYPELSTSMLLRPVKSPPTE
MAV_4615|M.avium_104 ----------------------RQEHLPHTPYPELSTGMLLRPVQPPPSE
MSMEG_0975|M.smegmatis_MC2_155 PMASGLPPLPPAPLTPPAAAAEQPPADFATPYEDLTTTALLGRRKSPPTA
TH_0884|M.thermoresistible__bu --------------------------------VDLSTTALLGQRRPAPSR
Mflv_0048|M.gilvum_PYR-GCK ----------------------------LVPYRELSTVALLGALPKAPSA
Mvan_0870|M.vanbaalenii_PYR-1 -----------------------------APYLDLSTVALLGNASRGPSA
MAB_3972c|M.abscessus_ATCC_199 VGGQ------------QTGVGGQIRPELPPSSRDLSTSALLRPHKPAPSA
MLBr_00798|M.leprae_Br4923 PAS-------------------RPQPTTFRHPYDDGRDLLVARRRPAAGD
: *: .
Mb0543|M.bovis_AF2122/97 GWRRLLYLLSGRLINAGEGPRAAHLNDLVAQVNRPLRGCYRIAVLSLKGG
Rv0530|M.tuberculosis_H37Rv GWRRLLYLLSGRLINAGEGPRAAHLNDLVAQVNRPLRGCYRIAVLSLKGG
MMAR_0876|M.marinum_M GWRRLVYVLSGQLINLGESPRATRYNNLVAQINRPMRGCYRIALVSLKGG
MAV_4615|M.avium_104 GWRLLLYKLSGGLINLGESPRAARYNNLVAQVNRPLRGSYRVAFLSLKGG
MSMEG_0975|M.smegmatis_MC2_155 GWRRWLYLASFKQVNVGESPKVTHRQSLVSQVSHPLQGCYRIAVLSLKGG
TH_0884|M.thermoresistible__bu GWRRWLYRATFRTVNLGESPKVARHNELLNRVRHPLQDCYRIAVLSLKGG
Mflv_0048|M.gilvum_PYR-GCK GWRKWVYRASGRLINPGESPKVIRHDDLLARVQQPLQGCYRVAMLSQKGG
Mvan_0870|M.vanbaalenii_PYR-1 GWRKWLYWGSGRLIDVGESPKVIRRNALVAQVQRPLRDCYRIAMLSQKGG
MAB_3972c|M.abscessus_ATCC_199 GWRKTVYRASFGTINLGEGTKKTEENDLIAQVNQPLQGCYKIALLSLKGG
MLBr_00798|M.leprae_Br4923 GWRKFVTKATLGRVNPEPSAKAEQTNELHRRICAPLADVHKVAFVSAKGG
*** : : :: ..: . : * :: *: . :::*.:* ***
Mb0543|M.bovis_AF2122/97 VGKTTITATLGATFADLRGDRVVAVDANPDRGTLSQKVP-LETPATVRHL
Rv0530|M.tuberculosis_H37Rv VGKTTITATLGATFADLRGDRVVAVDANPDRGTLSQKVP-LETPATVRHL
MMAR_0876|M.marinum_M VGKTTITATLGSTFASVRGDRVVAVDANPDRGTLSQKVP-LETPATVRHL
MAV_4615|M.avium_104 VGKTTIAATLGATFASIRGDRVVAVDANPDRGTLSQKIP-LETAATVRQL
MSMEG_0975|M.smegmatis_MC2_155 VGKTTITATLGSTFASIRGDRVIAVDANPDRGTLSQKVP-LETAATVRHL
TH_0884|M.thermoresistible__bu VGKTTITATLGSTFGSARGDRVVAVDANPDRGTLSQKVP-LQTRATVRDL
Mflv_0048|M.gilvum_PYR-GCK VGKTTITATLGATFAGARGDRVIAVDANPDRGTLSQKVP-VETPATVRHL
Mvan_0870|M.vanbaalenii_PYR-1 VGKTTITATLGATFATTRGDRVIAVDANPDRGTLSQKVP-LETPATVRHL
MAB_3972c|M.abscessus_ATCC_199 VGKTTVTATLGATFASIRGDRVIAVDANPDRGTLSQKVP-LETPATVRHL
MLBr_00798|M.leprae_Br4923 VGKTTITVALGNTMARLRGDRVIAVDVDADLGDLSARFRERGGPQTNIEH
*****::.:** *:. *****:***.:.* * ** :. * .
Mb0543|M.bovis_AF2122/97 LRDADGIERYSDVRGYTSKGPSGLEVLASDSDPASSDAFSADDYTRTLDI
Rv0530|M.tuberculosis_H37Rv LRDADGIERYSDVRGYTSKGPSGLEVLASDSDPASSDAFSADDYTRTLDI
MMAR_0876|M.marinum_M IRDAEGIERYSDVRGYTSQAKNGFEVLASDTDPAASEAFSADDYTRTLDI
MAV_4615|M.avium_104 LHDAGTIERYSDVRRYTSKGPSGLEVLASETDPAVSEAFSADDYVRILDI
MSMEG_0975|M.smegmatis_MC2_155 LRDAEGIERYSDVRAYTSQGPSRLEVLASESDPAVSEAFSSEDYLRTLEV
TH_0884|M.thermoresistible__bu LRDADRIQTYSDMRAYTSQSPSRLEVLASESDPAVSEAFSSDDYTRTLRV
Mflv_0048|M.gilvum_PYR-GCK LRDAEGVSAYSDVRRYTSQGPSRLEVLASESDPAVSEAFSATDYVRALNI
Mvan_0870|M.vanbaalenii_PYR-1 LRDAEGIAAYSDVRQYTSQGPSRLEVLASESDPAVSEAFSAADYCRAVDV
MAB_3972c|M.abscessus_ATCC_199 LRDANSIQRYSDVRSYTSQGPSRLEVLASESDPAVSEAFSAEDYSRTLEI
MLBr_00798|M.leprae_Br4923 FVSARNAKRYADVRVHTVMNNDRLEMLGAQNDPRSTYRLGPDDYETAMKI
: .* *:*:* :* . :*:*.::.** : :.. ** : :
Mb0543|M.bovis_AF2122/97 LERFYGLVLTDCGTGLLHSAMSAVLPRSDVLVVVSSGSIDGARSAAATLD
Rv0530|M.tuberculosis_H37Rv LERFYGLVLTDCGTGLLHSAMSAVLPRSDVLVVVSSGSIDGARSAAATLD
MMAR_0876|M.marinum_M LERFYGLVLTDCGTGLLHSAMSAILAKSDILIVVSSGSIDGARSASATLD
MAV_4615|M.avium_104 LERFYGLVLTDCGPGLLHSVMKSVLDKADALVVVSSASIDGARSASATLD
MSMEG_0975|M.smegmatis_MC2_155 LERFYSLVLTDCGTGLIHSAMSAVLSKADVLIVVSSGSVDGARSAAATLD
TH_0884|M.thermoresistible__bu LERFYSLVLTDCGTGLIHSAMSAVLANADVLIVISSGSVDGARSAAATLD
Mflv_0048|M.gilvum_PYR-GCK LERFYSMVLTDCGTGMLHSAMSAVIDKADVLVVISSGSADGARSASATLD
Mvan_0870|M.vanbaalenii_PYR-1 LERFYSVVLTDCGTGMLHSAMSGVIDKADVLVVISSGSVDGARSASATLD
MAB_3972c|M.abscessus_ATCC_199 LEKFYSVVLTDCGTGLMHSAMSSVLEQADTLVVISSGSVDGARSASATLD
MLBr_00798|M.leprae_Br4923 LENHCNVILLDCGTPVNGPLFNKIVSTVTGLVVVASDDVRGVEGALATLD
**.. .::* ***. : . :. :: *:*::* . *...* ****
Mb0543|M.bovis_AF2122/97 WLQAHGHDDQVRNSIAVVNAVRPR--------AGKVDVGKVVEHFSRRCR
Rv0530|M.tuberculosis_H37Rv WLQAHGHDDQVRNSIAVVNAVRPR--------AGKVDVGKVVEHFSRRCR
MMAR_0876|M.marinum_M WLEAHGYEELVRNSIAVINAVRPR--------SSKVDMQKVIDHFARRCR
MAV_4615|M.avium_104 WLDAHGHEDLVRNSIAVINGVRPR--------PGKVDMNKVIDHFSRRCR
MSMEG_0975|M.smegmatis_MC2_155 WLDAHGHQDLVRNSVAVLNAVRPR--------AGKVDLSKVVDHFSRRCR
TH_0884|M.thermoresistible__bu WLDAHGHQDMVRNSIAVINAVRPR--------SGKVDLQKVVDHFSRRCR
Mflv_0048|M.gilvum_PYR-GCK WLDAHGHDDMVRNSIAVINAVRPRGRRGTSRGTAKVDLDKIVDHFTRRCR
Mvan_0870|M.vanbaalenii_PYR-1 WLDAHGHGDMVGNSIAVINGVRRGARKGAGKGTAKVDLNKVVDHFARRCR
MAB_3972c|M.abscessus_ATCC_199 WLDAHGHRELVRRSIAVINAVRPR--------SGKVDMQKVVDHFSRRCR
MLBr_00798|M.leprae_Br4923 WLDAHGYARLLQHTVVVLNAIQKT--------KPFVDFGIVENQFRKRVP
**:***: : .::.*:*.:: **. : ::* :*
Mb0543|M.bovis_AF2122/97 AVRVVPFDPHLEEGAEIALDRLRRETREALTELAAVVAAGFP--------
Rv0530|M.tuberculosis_H37Rv AVRVVPFDPHLEEGAEIALDRLRRETREALTELAAVVAAGFP--------
MMAR_0876|M.marinum_M AVRLVPFDPHLEEGAEIVLDRMKRETREALAELAAVVAEGFG--------
MAV_4615|M.avium_104 AVQLVPFDPHLEEGAEIDLDRLRRGTREALTELAAIVADGFP--------
MSMEG_0975|M.smegmatis_MC2_155 AVRLVPFDPHLEEGAEISLDRLKPKTREALLELAAVVAGDFGSDRTGALG
TH_0884|M.thermoresistible__bu AVKMVPFDPHLEEGAEIDLDQLKPQTRQALLELAAVVADGFP--------
Mflv_0048|M.gilvum_PYR-GCK AVCQVPFDAHLEEGAEISLDRLRPQTRESLLELAAAVADGFP--------
Mvan_0870|M.vanbaalenii_PYR-1 AVCQVPFDPHLEEGAEISLDRLRADTRESLLELAAAVADGFP--------
MAB_3972c|M.abscessus_ATCC_199 AVRLVPFDPHLEEGAEISLDRLRPQTRRALIELAAVVAQGFT--------
MLBr_00798|M.leprae_Br4923 DFYPMPYDPHLATGLAVEYTSLKRKTRKALKELVGGVAQYYP--------
. :*:*.** * : :: **.:* **.. ** :
Mb0543|M.bovis_AF2122/97 -----GDPRRCKPSFT--------------
Rv0530|M.tuberculosis_H37Rv -----GDPRRCKPSFT--------------
MMAR_0876|M.marinum_M -----PDQRRSSPSFG--------------
MAV_4615|M.avium_104 -----G-AQRNPGVLG--------------
MSMEG_0975|M.smegmatis_MC2_155 GADSAGSRRIADPRV---------------
TH_0884|M.thermoresistible__bu -----GAQQLQSPPF---------------
Mflv_0048|M.gilvum_PYR-GCK -----GARNRSDPAD---------------
Mvan_0870|M.vanbaalenii_PYR-1 -----GAR-RTDPVG---------------
MAB_3972c|M.abscessus_ATCC_199 -----GTQRQQQTFQG--------------
MLBr_00798|M.leprae_Br4923 ---VIRAQQRDEDGLGTWIETIRQVEMTSR