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TTFRERRTMFDAAVASYQSGDKTSAGAAFARLTVENPDMSDSWLGRLACGDHNLDTLAGAHQHSEVLYSE TRRVGLKDGDLRAEIAAPMYLTLTTWSRATIGLAYASALINAGRYDEASVALDDPVVTEDDDAALARQFV MATLFHQTRSWSNVLKVAEVPPQNSNTDDRNELTDAVAALASTAASNLGQFQFALELTERVSTTNPQVAA DVALNRAWCLRELGDDNAARAALTAAPVNDIPTTHNTAEPASRPQPTTFRHPYDDGRDLLVARRRPAAGD GWRKFVTKATLGRVNPEPSAKAEQTNELHRRICAPLADVHKVAFVSAKGGVGKTTITVALGNTMARLRGD RVIAVDVDADLGDLSARFRERGGPQTNIEHFVSARNAKRYADVRVHTVMNNDRLEMLGAQNDPRSTYRLG PDDYETAMKILENHCNVILLDCGTPVNGPLFNKIVSTVTGLVVVASDDVRGVEGALATLDWLDAHGYARL LQHTVVVLNAIQKTKPFVDFGIVENQFRKRVPDFYPMPYDPHLATGLAVEYTSLKRKTRKALKELVGGVA QYYPVIRAQQRDEDGLGTWIETIRQVEMTSR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. leprae Br4923 | MLBr_00798 | - | - | 100% (592) | hypothetical protein MLBr_00798 |
| M. leprae Br4923 | MLBr_00048 | - | 4e-37 | 30.99% (284) | hypothetical protein MLBr_00048 |
| M. leprae Br4923 | MLBr_01536 | - | 7e-20 | 31.40% (207) | hypothetical protein MLBr_01536 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2810 | - | 0.0 | 76.49% (587) | hypothetical protein Mb2810 |
| M. gilvum PYR-GCK | Mflv_0048 | - | 1e-47 | 34.76% (328) | hypothetical protein Mflv_0048 |
| M. tuberculosis H37Rv | Rv2787 | - | 0.0 | 76.49% (587) | hypothetical protein Rv2787 |
| M. abscessus ATCC 19977 | MAB_3972c | - | 8e-55 | 37.91% (306) | hypothetical protein MAB_3972c |
| M. marinum M | MMAR_0876 | - | 4e-50 | 36.39% (316) | hypothetical protein MMAR_0876 |
| M. avium 104 | MAV_4615 | - | 1e-50 | 35.49% (355) | hypothetical protein MAV_4615 |
| M. smegmatis MC2 155 | MSMEG_0975 | - | 5e-54 | 37.42% (326) | hypothetical protein MSMEG_0975 |
| M. thermoresistible (build 8) | TH_0884 | - | 1e-54 | 38.26% (298) | conserved hypothetical protein |
| M. ulcerans Agy99 | MUL_3077 | - | 3e-20 | 34.30% (207) | hypothetical protein MUL_3077 |
| M. vanbaalenii PYR-1 | Mvan_0870 | - | 5e-46 | 35.01% (337) | hypothetical protein Mvan_0870 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2810|M.bovis_AF2122/97 ----MSTFRECRSMFDAAVKSY--------QSGDLANARAAFGRLTVENP
Rv2787|M.tuberculosis_H37Rv ----MSTFRECRSMFDAAVKSY--------QSGDLANARAAFGRLTVENP
MLBr_00798|M.leprae_Br4923 ----MTTFRERRTMFDAAVASY--------QSGDKTSAGAAFARLTVENP
MSMEG_0975|M.smegmatis_MC2_155 --------------------------------------------------
TH_0884|M.thermoresistible__bu --------------------------------------------------
MAB_3972c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_0048|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0870|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_0876|M.marinum_M --------------------------------------------------
MAV_4615|M.avium_104 --------------------------------------------------
MUL_3077|M.ulcerans_Agy99 MTRAQSAADDARNAMVAGLLASGISVNGLQPSHNPQVAAKMFITATKLDP
Mb2810|M.bovis_AF2122/97 DMSDGWLGLLACGDHHLDTLAGAHQHSEALYSETRRVGLTDGELSAVVMA
Rv2787|M.tuberculosis_H37Rv DMSDGWLGLLACGDHHLDTLAGAHQHSEALYSETRRVGLTDGELSAVVMA
MLBr_00798|M.leprae_Br4923 DMSDSWLGRLACGDHNLDTLAGAHQHSEVLYSETRRVGLKDGDLRAEIAA
MSMEG_0975|M.smegmatis_MC2_155 --------------------------------------------------
TH_0884|M.thermoresistible__bu --------------------------------------------------
MAB_3972c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_0048|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0870|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_0876|M.marinum_M --------------------------------------------------
MAV_4615|M.avium_104 --------------------------------------------------
MUL_3077|M.ulcerans_Agy99 AMCDAWLARLLAGDQTMDVLAGAWAAVRTFGWETRRLGVTDLQFRPEVSD
Mb2810|M.bovis_AF2122/97 PMYLGLRVWSRATIGLAYASALIIADRHDEAAATLDDPVITEDTGAAQYR
Rv2787|M.tuberculosis_H37Rv PMYLGLRVWSRATIGLAYASALIIADRHDEAAATLDDPVITEDTGAAQYR
MLBr_00798|M.leprae_Br4923 PMYLTLTTWSRATIGLAYASALINAGRYDEASVALDDPVVTEDDDAALAR
MSMEG_0975|M.smegmatis_MC2_155 -------MSASSEHPVPDS----------VDVPAPEHP---------AAE
TH_0884|M.thermoresistible__bu --------------------------------------------------
MAB_3972c|M.abscessus_ATCC_199 -------MSDYPAHRAPDG----------PSPYAADEAQGGPTAPPWAAQ
Mflv_0048|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0870|M.vanbaalenii_PYR-1 ------------------------------------------------MD
MMAR_0876|M.marinum_M -----MDVSDHPSAGVGASNAYQGEGGKDHPTIQLPPVPHQ---PPQLGE
MAV_4615|M.avium_104 -------MSEHPTAGVGAP---------EEQTTQIPPAAAAGDDKKDAAE
MUL_3077|M.ulcerans_Agy99 GLFLRLAVTSVDSLACAYAAVLAGNKRYQEASDLLGTTDPKHPFDAELVS
Mb2810|M.bovis_AF2122/97 QFVMATLFHKTRSWSNLLKVTEISPPSGATDVRDEVADAVAALASTAAAS
Rv2787|M.tuberculosis_H37Rv QFVMATLFHKTRSWSNLLKVTEISPPSGATDVRDEVADAVAALASTAAAS
MLBr_00798|M.leprae_Br4923 QFVMATLFHQTRSWSNVLKVAEVPPQNSNTDDRNELTDAVAALASTAASN
MSMEG_0975|M.smegmatis_MC2_155 TPEAPSVFAPVPG------------------FRGQQRFS----DPAQAGV
TH_0884|M.thermoresistible__bu --------------------------------------------------
MAB_3972c|M.abscessus_ATCC_199 EPAQPVMYGQSTPQQPHEMTQQFQAVPFQDPFAPQQDIAGLGHDPAVPSL
Mflv_0048|M.gilvum_PYR-GCK --MS---------------------------FRAQQRFS----DPMAP--
Mvan_0870|M.vanbaalenii_PYR-1 APGS---------------------------FRAQQRFS----DPMAP--
MMAR_0876|M.marinum_M PPVAGGSDAPTRAFAG---------------FRTERRSAA---RAEGAEA
MAV_4615|M.avium_104 PQPEPGGDAPTKAFAG---------------FRTERRVPE---REPAPPT
MUL_3077|M.ulcerans_Agy99 YVRGVLYFRTKRWPDVLAQFPEATP-----WRHPELKAAGAAMATTALAS
Mb2810|M.bovis_AF2122/97 LGQFQFALELAEQVSTTNPRVTADVTLTRAWCLRELGDDDAARVALSATT
Rv2787|M.tuberculosis_H37Rv LGQFQFALELAEQVSTTNPRVTADVTLTRAWCLRELGDDDAARVALSATT
MLBr_00798|M.leprae_Br4923 LGQFQFALELTERVSTTNPQVAADVALNRAWCLRELGDDNAARAALTAAP
MSMEG_0975|M.smegmatis_MC2_155 STPLPAEWTAPTPPHGIPVSAPQTAQTPPQNSHQP---------MASGLP
TH_0884|M.thermoresistible__bu --------------------------------------------------
MAB_3972c|M.abscessus_ATCC_199 NSLGGSFAPLDFTPSGSQEAGDPTAVGAAGSSGGPGGFRADNRFSDSGEQ
Mflv_0048|M.gilvum_PYR-GCK ---VPAEWTAPTPPEG----------------------------------
Mvan_0870|M.vanbaalenii_PYR-1 ---VPAEWTAPTPPEG----------------------------------
MMAR_0876|M.marinum_M PDVAQWESGPDTGPVAGLPRVDPTAYGAYYNG------------------
MAV_4615|M.avium_104 APRPGGMPPWDSTPVTGIPRVDPTAYGAYYAG------------------
MUL_3077|M.ulcerans_Agy99 LGVFEEAFRRAQEAIEGDRVPGAANIALYTQGMCLRHVGREEEAVVLLRR
Mb2810|M.bovis_AF2122/97 TGDAPRTNTTAEQAGSPQPK------------------------------
Rv2787|M.tuberculosis_H37Rv TGDAPRTNTTAEQAGSPQPK------------------------------
MLBr_00798|M.leprae_Br4923 VNDIPTTHNTAEPASRPQPTT-----------------------------
MSMEG_0975|M.smegmatis_MC2_155 PLPPAPLTPPAAAAEQPPA-------------------------------
TH_0884|M.thermoresistible__bu --------------------------------------------------
MAB_3972c|M.abscessus_ATCC_199 PAQPTPFTADRWASDTPPSGIPQQAQQPPVGGSRYYTPVGGQQTGVGGQI
Mflv_0048|M.gilvum_PYR-GCK -------VVPVVAAATPST-------------------------------
Mvan_0870|M.vanbaalenii_PYR-1 -------APPVVTADP----------------------------------
MMAR_0876|M.marinum_M -----PPEPPAEPQYRP---------------------------------
MAV_4615|M.avium_104 -----PDAPPTQIQGPPPRQ------------------------------
MUL_3077|M.ulcerans_Agy99 VYSRDAKFSPAREALDNPNYRLVLTDPETIEARKD-----------PWDP
Mb2810|M.bovis_AF2122/97 ----FRHPYDDGRDLLVARRRPPAGDGWRKAVTKMTFGRVNPEPSAKREQ
Rv2787|M.tuberculosis_H37Rv ----FRHPYDDGRDLLVARRRPPAGDGWRKAVTKMTFGRVNPEPSAKREQ
MLBr_00798|M.leprae_Br4923 ----FRHPYDDGRDLLVARRRPAAGDGWRKFVTKATLGRVNPEPSAKAEQ
MSMEG_0975|M.smegmatis_MC2_155 --DFATPYEDLTTTALLGRRKSPPTAGWRRWLYLASFKQVNVGESPKVTH
TH_0884|M.thermoresistible__bu --------VDLSTTALLGQRRPAPSRGWRRWLYRATFRTVNLGESPKVAR
MAB_3972c|M.abscessus_ATCC_199 RPELPPSSRDLSTSALLRPHKPAPSAGWRKTVYRASFGTINLGEGTKKTE
Mflv_0048|M.gilvum_PYR-GCK ---ELVPYRELSTVALLGALPKAPSAGWRKWVYRASGRLINPGESPKVIR
Mvan_0870|M.vanbaalenii_PYR-1 -----APYLDLSTVALLGNASRGPSAGWRKWLYWGSGRLIDVGESPKVIR
MMAR_0876|M.marinum_M ESVPQTPYPELSTSMLLRPVKSPPTEGWRRLVYVLSGQLINLGESPRATR
MAV_4615|M.avium_104 EHLPHTPYPELSTGMLLRPVQPPPSEGWRLLLYKLSGGLINLGESPRAAR
MUL_3077|M.ulcerans_Agy99 DSAPTRAQTEAARHAEMAAKYLAEGDAELNAMLGMEQAKKEIKLIKSTTK
: : . : : .
Mb2810|M.bovis_AF2122/97 TDELIQRICAPLADVHKLAFVSAKGGVGKTTMTVLVGNAVARLRGDRVMA
Rv2787|M.tuberculosis_H37Rv TDELIQRICAPLADVHKLAFVSAKGGVGKTTMTVLVGNAVARLRGDRVMA
MLBr_00798|M.leprae_Br4923 TNELHRRICAPLADVHKVAFVSAKGGVGKTTITVALGNTMARLRGDRVIA
MSMEG_0975|M.smegmatis_MC2_155 RQSLVSQVSHPLQGCYRIAVLSLKGGVGKTTITATLGSTFASIRGDRVIA
TH_0884|M.thermoresistible__bu HNELLNRVRHPLQDCYRIAVLSLKGGVGKTTITATLGSTFGSARGDRVVA
MAB_3972c|M.abscessus_ATCC_199 ENDLIAQVNQPLQGCYKIALLSLKGGVGKTTVTATLGATFASIRGDRVIA
Mflv_0048|M.gilvum_PYR-GCK HDDLLARVQQPLQGCYRVAMLSQKGGVGKTTITATLGATFAGARGDRVIA
Mvan_0870|M.vanbaalenii_PYR-1 RNALVAQVQRPLRDCYRIAMLSQKGGVGKTTITATLGATFATTRGDRVIA
MMAR_0876|M.marinum_M YNNLVAQINRPMRGCYRIALVSLKGGVGKTTITATLGSTFASVRGDRVVA
MAV_4615|M.avium_104 YNNLVAQVNRPLRGSYRVAFLSLKGGVGKTTIAATLGATFASIRGDRVVA
MUL_3077|M.ulcerans_Agy99 VNLARAKMGLPVPVTSRHTLLLGPPGTGKTSVARAFTKQLCGLTVLRKPL
: :: *: : :.: *.***::: . . *
Mb2810|M.bovis_AF2122/97 VDVDADLGDLSARFSERGGPQTNIEHFVSSQHTKRYADVRVHTVMNKDR-
Rv2787|M.tuberculosis_H37Rv VDVDADLGDLSARFSERGGPQTNIEHFVSSQHTKRYADVRVHTVMNKDR-
MLBr_00798|M.leprae_Br4923 VDVDADLGDLSARFRERGGPQTNIEHFVSARNAKRYADVRVHTVMNNDR-
MSMEG_0975|M.smegmatis_MC2_155 VDANPDRGTLSQKVP-LETAATVRHLLRDAEGIERYSDVRAYTSQGPSR-
TH_0884|M.thermoresistible__bu VDANPDRGTLSQKVP-LQTRATVRDLLRDADRIQTYSDMRAYTSQSPSR-
MAB_3972c|M.abscessus_ATCC_199 VDANPDRGTLSQKVP-LETPATVRHLLRDANSIQRYSDVRSYTSQGPSR-
Mflv_0048|M.gilvum_PYR-GCK VDANPDRGTLSQKVP-VETPATVRHLLRDAEGVSAYSDVRRYTSQGPSR-
Mvan_0870|M.vanbaalenii_PYR-1 VDANPDRGTLSQKVP-LETPATVRHLLRDAEGIAAYSDVRQYTSQGPSR-
MMAR_0876|M.marinum_M VDANPDRGTLSQKVP-LETPATVRHLIRDAEGIERYSDVRGYTSQAKNG-
MAV_4615|M.avium_104 VDANPDRGTLSQKIP-LETAATVRQLLHDAGTIERYSDVRRYTSKGPSG-
MUL_3077|M.ulcerans_Agy99 VVETSRTKLLGRYMADAEKN-TEEMLEGSLGGAVFFDEMHTLHEKGYSQG
* . *. . * . : ::: .
Mb2810|M.bovis_AF2122/97 ---------LEMLGAQNDPRSTYKFGPEDYGAAMQILETHCNVILLDCGT
Rv2787|M.tuberculosis_H37Rv ---------LEMLGAQNDPRSTYKFGPEDYGAAMQILETHCNVILLDCGT
MLBr_00798|M.leprae_Br4923 ---------LEMLGAQNDPRSTYRLGPDDYETAMKILENHCNVILLDCGT
MSMEG_0975|M.smegmatis_MC2_155 ---------LEVLASESDPAVSEAFSSEDYLRTLEVLERFYSLVLTDCGT
TH_0884|M.thermoresistible__bu ---------LEVLASESDPAVSEAFSSDDYTRTLRVLERFYSLVLTDCGT
MAB_3972c|M.abscessus_ATCC_199 ---------LEVLASESDPAVSEAFSAEDYSRTLEILEKFYSVVLTDCGT
Mflv_0048|M.gilvum_PYR-GCK ---------LEVLASESDPAVSEAFSATDYVRALNILERFYSMVLTDCGT
Mvan_0870|M.vanbaalenii_PYR-1 ---------LEVLASESDPAVSEAFSAADYCRAVDVLERFYSVVLTDCGT
MMAR_0876|M.marinum_M ---------FEVLASDTDPAASEAFSADDYTRTLDILERFYGLVLTDCGT
MAV_4615|M.avium_104 ---------LEVLASETDPAVSEAFSADDYVRILDILERFYGLVLTDCGP
MUL_3077|M.ulcerans_Agy99 DPYGNAIINTLLLYMENHRDELVVFGAGYAKAMEKMLEVNQGLRRRFSTV
:* :.. :.. :** .: .
Mb2810|M.bovis_AF2122/97 PVNGPLFSNILNDVTGLVVVASEDVRGVEGALVTLDWLGAHGFGRLLQHT
Rv2787|M.tuberculosis_H37Rv PVNGPLFSNILNDVTGLVVVASEDVRGVEGALVTLDWLGAHGFGRLLQHT
MLBr_00798|M.leprae_Br4923 PVNGPLFNKIVSTVTGLVVVASDDVRGVEGALATLDWLDAHGYARLLQHT
MSMEG_0975|M.smegmatis_MC2_155 GLIHSAMSAVLSKADVLIVVSSGSVDGARSAAATLDWLDAHGHQDLVRNS
TH_0884|M.thermoresistible__bu GLIHSAMSAVLANADVLIVISSGSVDGARSAAATLDWLDAHGHQDMVRNS
MAB_3972c|M.abscessus_ATCC_199 GLMHSAMSSVLEQADTLVVISSGSVDGARSASATLDWLDAHGHRELVRRS
Mflv_0048|M.gilvum_PYR-GCK GMLHSAMSAVIDKADVLVVISSGSADGARSASATLDWLDAHGHDDMVRNS
Mvan_0870|M.vanbaalenii_PYR-1 GMLHSAMSGVIDKADVLVVISSGSVDGARSASATLDWLDAHGHGDMVGNS
MMAR_0876|M.marinum_M GLLHSAMSAILAKSDILIVVSSGSIDGARSASATLDWLEAHGYEELVRNS
MAV_4615|M.avium_104 GLLHSVMKSVLDKADALVVVSSASIDGARSASATLDWLDAHGHEDLVRNS
MUL_3077|M.ulcerans_Agy99 IEFFSYTPEELIALTKLMGHENEDVITEEEAQVLLPSYTRFYNDQNYSED
. : *: . . . * . * . .
Mb2810|M.bovis_AF2122/97 VVVLNAIQKT--------RSLVDCGAAENQFRKRVPDFFRIPYDPHLATG
Rv2787|M.tuberculosis_H37Rv VVVLNAIQKT--------RSLVDCGAAENQFRKRVPDFFRIPYDPHLATG
MLBr_00798|M.leprae_Br4923 VVVLNAIQKT--------KPFVDFGIVENQFRKRVPDFYPMPYDPHLATG
MSMEG_0975|M.smegmatis_MC2_155 VAVLNAVRPR--------AGKVDLSKVVDHFSRRCRAVRLVPFDPHLEEG
TH_0884|M.thermoresistible__bu IAVINAVRPR--------SGKVDLQKVVDHFSRRCRAVKMVPFDPHLEEG
MAB_3972c|M.abscessus_ATCC_199 IAVINAVRPR--------SGKVDMQKVVDHFSRRCRAVRLVPFDPHLEEG
Mflv_0048|M.gilvum_PYR-GCK IAVINAVRPRGRRGTSRGTAKVDLDKIVDHFTRRCRAVCQVPFDAHLEEG
Mvan_0870|M.vanbaalenii_PYR-1 IAVINGVRRGARKGAGKGTAKVDLNKVVDHFARRCRAVCQVPFDPHLEEG
MMAR_0876|M.marinum_M IAVINAVRPR--------SSKVDMQKVIDHFARRCRAVRLVPFDPHLEEG
MAV_4615|M.avium_104 IAVINGVRPR--------PGKVDMNKVIDHFSRRCRAVQLVPFDPHLEEG
MUL_3077|M.ulcerans_Agy99 GDLIRGIDMLG--NAGFVRNVVEKARDHRSFRLDDEDLDAV-LNSDLMEF
::..: *: * . : :..*
Mb2810|M.bovis_AF2122/97 LAVDFSSLKRRTRNAVLD-LAGGLAQHYPASRVRPRGEDSWKTWIETMRQ
Rv2787|M.tuberculosis_H37Rv LAVDFSSLKRRTRNAVLD-LAGGLAQHYPASRVRPRGEDSWKTWIETMRQ
MLBr_00798|M.leprae_Br4923 LAVEYTSLKRKTRKALKE-LVGGVAQYYPVIRAQQRDEDGLGTWIETIRQ
MSMEG_0975|M.smegmatis_MC2_155 AEISLDRLKPKTREALLE-LAAVVAGDFGSDRTGALGGADSAGSRRIADP
TH_0884|M.thermoresistible__bu AEIDLDQLKPQTRQALLE-LAAVVADGFP-------------GAQQLQSP
MAB_3972c|M.abscessus_ATCC_199 AEISLDRLRPQTRRALIE-LAAVVAQGFT-------------GTQRQQQT
Mflv_0048|M.gilvum_PYR-GCK AEISLDRLRPQTRESLLE-LAAAVADGFP-------------GARNRSDP
Mvan_0870|M.vanbaalenii_PYR-1 AEISLDRLRADTRESLLE-LAAAVADGFP-------------GAR-RTDP
MMAR_0876|M.marinum_M AEIVLDRMKRETREALAE-LAAVVAEGFG------------PDQRRSSPS
MAV_4615|M.avium_104 AEIDLDRLRRGTREALTE-LAAIVADGF-------------PGAQRNPGV
MUL_3077|M.ulcerans_Agy99 SELQMRRFRELTKEDLAEGLSAAVAEKKTN--------------------
: :: *:. : : * . :*
Mb2810|M.bovis_AF2122/97 VG----
Rv2787|M.tuberculosis_H37Rv VG----
MLBr_00798|M.leprae_Br4923 VEMTSR
MSMEG_0975|M.smegmatis_MC2_155 RV----
TH_0884|M.thermoresistible__bu PF----
MAB_3972c|M.abscessus_ATCC_199 FQG---
Mflv_0048|M.gilvum_PYR-GCK AD----
Mvan_0870|M.vanbaalenii_PYR-1 VG----
MMAR_0876|M.marinum_M FG----
MAV_4615|M.avium_104 LG----
MUL_3077|M.ulcerans_Agy99 ------