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SFRAQQRFSDPMAPVPAEWTAPTPPEGVVPVVAAATPSTELVPYRELSTVALLGALPKAPSAGWRKWVYR ASGRLINPGESPKVIRHDDLLARVQQPLQGCYRVAMLSQKGGVGKTTITATLGATFAGARGDRVIAVDAN PDRGTLSQKVPVETPATVRHLLRDAEGVSAYSDVRRYTSQGPSRLEVLASESDPAVSEAFSATDYVRALN ILERFYSMVLTDCGTGMLHSAMSAVIDKADVLVVISSGSADGARSASATLDWLDAHGHDDMVRNSIAVIN AVRPRGRRGTSRGTAKVDLDKIVDHFTRRCRAVCQVPFDAHLEEGAEISLDRLRPQTRESLLELAAAVAD GFPGARNRSDPAD*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_0048 | - | - | 100% (364) | hypothetical protein Mflv_0048 |
| M. gilvum PYR-GCK | Mflv_0765 | - | 3e-56 | 37.58% (314) | hypothetical protein Mflv_0765 |
| M. gilvum PYR-GCK | Mflv_0776 | - | 3e-39 | 31.08% (370) | hypothetical protein Mflv_0776 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0543 | - | 1e-127 | 68.13% (342) | hypothetical protein Mb0543 |
| M. tuberculosis H37Rv | Rv0530 | - | 1e-127 | 68.13% (342) | hypothetical protein Rv0530 |
| M. leprae Br4923 | MLBr_00048 | - | 4e-49 | 35.10% (359) | hypothetical protein MLBr_00048 |
| M. abscessus ATCC 19977 | MAB_3972c | - | 1e-132 | 65.97% (385) | hypothetical protein MAB_3972c |
| M. marinum M | MMAR_0876 | - | 1e-124 | 62.89% (353) | hypothetical protein MMAR_0876 |
| M. avium 104 | MAV_4615 | - | 1e-123 | 65.90% (349) | hypothetical protein MAV_4615 |
| M. smegmatis MC2 155 | MSMEG_0975 | - | 1e-140 | 64.89% (393) | hypothetical protein MSMEG_0975 |
| M. thermoresistible (build 8) | TH_0884 | - | 1e-132 | 73.73% (316) | conserved hypothetical protein |
| M. ulcerans Agy99 | MUL_3237 | - | 3e-06 | 36.72% (128) | Soj family ATPase |
| M. vanbaalenii PYR-1 | Mvan_0870 | - | 1e-168 | 82.27% (361) | hypothetical protein Mvan_0870 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0543|M.bovis_AF2122/97 --------------------------------------------------
Rv0530|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0876|M.marinum_M --------------------------------------------------
MAV_4615|M.avium_104 --------------------------------------------------
Mflv_0048|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0870|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0975|M.smegmatis_MC2_155 --------------------------------------------------
TH_0884|M.thermoresistible__bu --------------------------------------------------
MAB_3972c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_00048|M.leprae_Br4923 MAADYDKLFRLDDGAYASPDQAAEQLFDDAPLYPPPIIPTCTTTPNGEVA
MUL_3237|M.ulcerans_Agy99 --------------------------------------------------
Mb0543|M.bovis_AF2122/97 --------------------------------------------------
Rv0530|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0876|M.marinum_M --------------------------------------------------
MAV_4615|M.avium_104 --------------------------------------------------
Mflv_0048|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0870|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0975|M.smegmatis_MC2_155 --------------------------------------------------
TH_0884|M.thermoresistible__bu --------------------------------------------------
MAB_3972c|M.abscessus_ATCC_199 ----------------------MSDYPAHRAPDGPSPYAADEAQGGPTAP
MLBr_00048|M.leprae_Br4923 SPMPDWSEQLPPNPPAASKSPLPPMPIGSSVQPPPASSESPRAPMPVSAP
MUL_3237|M.ulcerans_Agy99 --------------------------------------------------
Mb0543|M.bovis_AF2122/97 -----------------------------------MLVTEHPRTGVGAPD
Rv0530|M.tuberculosis_H37Rv -----------------------------------MLVTEHPRTGVGAPD
MMAR_0876|M.marinum_M -----------------------------------MDVSDHPSAGVGASN
MAV_4615|M.avium_104 -------------------------------------MSEHPTAGVGAPE
Mflv_0048|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0870|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0975|M.smegmatis_MC2_155 --------------------------------------------------
TH_0884|M.thermoresistible__bu --------------------------------------------------
MAB_3972c|M.abscessus_ATCC_199 PWAAQEPAQPVMYGQSTPQQPHEMTQQFQAVPFQDPFAPQQDIAGLGHDP
MLBr_00048|M.leprae_Br4923 PRSPAASLMPISEPPQWPPAEAPEHQFAKAEPPSVPIPINEPSPAKPATP
MUL_3237|M.ulcerans_Agy99 --------------------------------------------------
Mb0543|M.bovis_AF2122/97 S----GNGGTDHPTVQLPPVPS-------VGAPPAAAGGETPTRSVAGFR
Rv0530|M.tuberculosis_H37Rv S----GNGGTDHPTVQLPPVPS-------VGAPPAAAGGETPTRSVAGFR
MMAR_0876|M.marinum_M AY--QGEGGKDHPTIQLPPVPHQ---PPQLGEPPVAGGSDAPTRAFAGFR
MAV_4615|M.avium_104 E-----------QTTQIPPAAAAGDDKKDAAEPQPEPGGDAPTKAFAGFR
Mflv_0048|M.gilvum_PYR-GCK ----------------------------------------------MSFR
Mvan_0870|M.vanbaalenii_PYR-1 ------------------------------------------MDAPGSFR
MSMEG_0975|M.smegmatis_MC2_155 -----MSASSEHPVPDSVDVPAP------EHPAAETPEAPSVFAPVPGFR
TH_0884|M.thermoresistible__bu --------------------------------------------------
MAB_3972c|M.abscessus_ATCC_199 AVPSLNSLGGSFAPLDFTPSGSQ------EAGDPTAVGAAGSSGGPGGFR
MLBr_00048|M.leprae_Br4923 MPMTPIDGSQRTPVTSPEPSLAEFEAQPPATPKPSLLPRPMSSPPEAPRP
MUL_3237|M.ulcerans_Agy99 --------------------------------------------------
Mb0543|M.bovis_AF2122/97 TQR-------------------------------LDPTAYGAYYSGPDEG
Rv0530|M.tuberculosis_H37Rv TQR-------------------------------LDPTAYGAYYSGPDEG
MMAR_0876|M.marinum_M TERRSAARAEGAEAPDVAQWESGPDTGPVAGLPRVDPTAYGAYYNGPPEP
MAV_4615|M.avium_104 TERRVPEREPAPPTAPRPGGMPPWDSTPVTGIPRVDPTAYGAYYAGPDAP
Mflv_0048|M.gilvum_PYR-GCK AQQRFSDP------MAPVPAE-WTAPTPPEGVVP----------------
Mvan_0870|M.vanbaalenii_PYR-1 AQQRFSDP------MAPVPAE-WTAPTPPEGAPP----------------
MSMEG_0975|M.smegmatis_MC2_155 GQQRFSDPA-QAGVSTPLPAE-WTAPTPPHGIPVSAPQTAQTPPQNSHQP
TH_0884|M.thermoresistible__bu --------------------------------------------------
MAB_3972c|M.abscessus_ATCC_199 ADNRFSDSGEQPAQPTPFTADRWASDTPPSGIPQQAQQPPVGGSRYYTPV
MLBr_00048|M.leprae_Br4923 SANQHSRHARRGHHHRDETQQANPASATEPMIAPRARTAELRQAPHAAAE
MUL_3237|M.ulcerans_Agy99 --------------------------------------------------
Mb0543|M.bovis_AF2122/97 PASP-----------AERPPYRLEPVPHTPYPELATTTLLRPVKPPPSEG
Rv0530|M.tuberculosis_H37Rv PASP-----------AERPPYRLEPVPHTPYPELATTTLLRPVKPPPSEG
MMAR_0876|M.marinum_M PAEP-----------QYRP----ESVPQTPYPELSTSMLLRPVKSPPTEG
MAV_4615|M.avium_104 PTQI-----------QGPPP-RQEHLPHTPYPELSTGMLLRPVQPPPSEG
Mflv_0048|M.gilvum_PYR-GCK -----------------VVAAATPSTELVPYRELSTVALLGALPKAPSAG
Mvan_0870|M.vanbaalenii_PYR-1 -----------------VVTADP-----APYLDLSTVALLGNASRGPSAG
MSMEG_0975|M.smegmatis_MC2_155 MASGLPPLPPAPLTPPAAAAEQPPADFATPYEDLTTTALLGRRKSPPTAG
TH_0884|M.thermoresistible__bu -------------------------------VDLSTTALLGQRRPAPSRG
MAB_3972c|M.abscessus_ATCC_199 GGQ------------QTGVGGQIRPELPPSSRDLSTSALLRPHKPAPSAG
MLBr_00048|M.leprae_Br4923 PAPTQHLTRPDGLVSHRTALHDSTATSAIGVQTGRSTGAKKPSKVVAKRG
MUL_3237|M.ulcerans_Agy99 ---------------------MPAGLPAQADAAVRLSCDVHPDVLHNASR
Mb0543|M.bovis_AF2122/97 WRRLLYLLSGRLINAGEGPRAAHLNDLVAQVNRPLRGCYRIAVLSLKGGV
Rv0530|M.tuberculosis_H37Rv WRRLLYLLSGRLINAGEGPRAAHLNDLVAQVNRPLRGCYRIAVLSLKGGV
MMAR_0876|M.marinum_M WRRLVYVLSGQLINLGESPRATRYNNLVAQINRPMRGCYRIALVSLKGGV
MAV_4615|M.avium_104 WRLLLYKLSGGLINLGESPRAARYNNLVAQVNRPLRGSYRVAFLSLKGGV
Mflv_0048|M.gilvum_PYR-GCK WRKWVYRASGRLINPGESPKVIRHDDLLARVQQPLQGCYRVAMLSQKGGV
Mvan_0870|M.vanbaalenii_PYR-1 WRKWLYWGSGRLIDVGESPKVIRRNALVAQVQRPLRDCYRIAMLSQKGGV
MSMEG_0975|M.smegmatis_MC2_155 WRRWLYLASFKQVNVGESPKVTHRQSLVSQVSHPLQGCYRIAVLSLKGGV
TH_0884|M.thermoresistible__bu WRRWLYRATFRTVNLGESPKVARHNELLNRVRHPLQDCYRIAVLSLKGGV
MAB_3972c|M.abscessus_ATCC_199 WRKTVYRASFGTINLGEGTKKTEENDLIAQVNQPLQGCYKIALLSLKGGV
MLBr_00048|M.leprae_Br4923 WRHWVHTVTR--INLGLSPDERYELDLRTRVRRPPRGSYQIGILGLKGGA
MUL_3237|M.ulcerans_Agy99 SGMNDHPDSGVSVGLTGRPPRAIPDPKPLSSHGPAK---VVAMCNQKGGV
: : :. . * : :.. . ***.
Mb0543|M.bovis_AF2122/97 GKTTITATLGATFADLRGDRVVAVDANPDRGTLS--QKVPLETPATVRHL
Rv0530|M.tuberculosis_H37Rv GKTTITATLGATFADLRGDRVVAVDANPDRGTLS--QKVPLETPATVRHL
MMAR_0876|M.marinum_M GKTTITATLGSTFASVRGDRVVAVDANPDRGTLS--QKVPLETPATVRHL
MAV_4615|M.avium_104 GKTTIAATLGATFASIRGDRVVAVDANPDRGTLS--QKIPLETAATVRQL
Mflv_0048|M.gilvum_PYR-GCK GKTTITATLGATFAGARGDRVIAVDANPDRGTLS--QKVPVETPATVRHL
Mvan_0870|M.vanbaalenii_PYR-1 GKTTITATLGATFATTRGDRVIAVDANPDRGTLS--QKVPLETPATVRHL
MSMEG_0975|M.smegmatis_MC2_155 GKTTITATLGSTFASIRGDRVIAVDANPDRGTLS--QKVPLETAATVRHL
TH_0884|M.thermoresistible__bu GKTTITATLGSTFGSARGDRVVAVDANPDRGTLS--QKVPLQTRATVRDL
MAB_3972c|M.abscessus_ATCC_199 GKTTVTATLGATFASIRGDRVIAVDANPDRGTLS--QKVPLETPATVRHL
MLBr_00048|M.leprae_Br4923 GKTTVTVTLGSMFARVRNDRILVVDADTSCGNLA--DRAGRFSEANIADL
MUL_3237|M.ulcerans_Agy99 GKTTSTINLGAALAEYDR-RVLLVDMDPQGALSAGLGVAHYELEKTIHNV
**** : .**: :. *:: ** :.. . : .: .:
Mb0543|M.bovis_AF2122/97 LRDADGIERYSDVRGYTS---KGPSGLEVLASDSDPASSDAFSADDYTRT
Rv0530|M.tuberculosis_H37Rv LRDADGIERYSDVRGYTS---KGPSGLEVLASDSDPASSDAFSADDYTRT
MMAR_0876|M.marinum_M IRDAEGIERYSDVRGYTS---QAKNGFEVLASDTDPAASEAFSADDYTRT
MAV_4615|M.avium_104 LHDAGTIERYSDVRRYTS---KGPSGLEVLASETDPAVSEAFSADDYVRI
Mflv_0048|M.gilvum_PYR-GCK LRDAEGVSAYSDVRRYTS---QGPSRLEVLASESDPAVSEAFSATDYVRA
Mvan_0870|M.vanbaalenii_PYR-1 LRDAEGIAAYSDVRQYTS---QGPSRLEVLASESDPAVSEAFSAADYCRA
MSMEG_0975|M.smegmatis_MC2_155 LRDAEGIERYSDVRAYTS---QGPSRLEVLASESDPAVSEAFSSEDYLRT
TH_0884|M.thermoresistible__bu LRDADRIQTYSDMRAYTS---QSPSRLEVLASESDPAVSEAFSSDDYTRT
MAB_3972c|M.abscessus_ATCC_199 LRDANSIQRYSDVRSYTS---QGPSRLEVLASESDPAVSEAFSAEDYSRT
MLBr_00048|M.leprae_Br4923 LADKD-VKSYNDIRTHTS---VNAVNLEVLPAAEYSTAQHALSGEDWNFA
MUL_3237|M.ulcerans_Agy99 LVEPRVSVDDVLIHTRVKNLDLVPSNIDLSAAEIQ-LVNEVGREQTLGRA
: : :: .. ::: .: ...
Mb0543|M.bovis_AF2122/97 LDILERFYGLVLTDCGTGLLHSAMSAVLPRSDVLVVVSSGSIDGARSAAA
Rv0530|M.tuberculosis_H37Rv LDILERFYGLVLTDCGTGLLHSAMSAVLPRSDVLVVVSSGSIDGARSAAA
MMAR_0876|M.marinum_M LDILERFYGLVLTDCGTGLLHSAMSAILAKSDILIVVSSGSIDGARSASA
MAV_4615|M.avium_104 LDILERFYGLVLTDCGPGLLHSVMKSVLDKADALVVVSSASIDGARSASA
Mflv_0048|M.gilvum_PYR-GCK LNILERFYSMVLTDCGTGMLHSAMSAVIDKADVLVVISSGSADGARSASA
Mvan_0870|M.vanbaalenii_PYR-1 VDVLERFYSVVLTDCGTGMLHSAMSGVIDKADVLVVISSGSVDGARSASA
MSMEG_0975|M.smegmatis_MC2_155 LEVLERFYSLVLTDCGTGLIHSAMSAVLSKADVLIVVSSGSVDGARSAAA
TH_0884|M.thermoresistible__bu LRVLERFYSLVLTDCGTGLIHSAMSAVLANADVLIVISSGSVDGARSAAA
MAB_3972c|M.abscessus_ATCC_199 LEILEKFYSVVLTDCGTGLMHSAMSSVLEQADTLVVISSGSVDGARSASA
MLBr_00048|M.leprae_Br4923 AATVSKYYNVMLADCGVGLFDPVTRGVLSTASGVVIVTSTSVDAARQAAI
MUL_3237|M.ulcerans_Agy99 LYPVLDRYDYVLVDCQPSLGLLTVNG-LACADGVVIPTECEYFSLRGLAL
: *. :*.** .: . . : :. ::: :. . . * :
Mb0543|M.bovis_AF2122/97 TLDWLQAHGHDDQVRNSIAVVNAVRPRA--------GKVDVGKVVEHFSR
Rv0530|M.tuberculosis_H37Rv TLDWLQAHGHDDQVRNSIAVVNAVRPRA--------GKVDVGKVVEHFSR
MMAR_0876|M.marinum_M TLDWLEAHGYEELVRNSIAVINAVRPRS--------SKVDMQKVIDHFAR
MAV_4615|M.avium_104 TLDWLDAHGHEDLVRNSIAVINGVRPRP--------GKVDMNKVIDHFSR
Mflv_0048|M.gilvum_PYR-GCK TLDWLDAHGHDDMVRNSIAVINAVRPRGRRGTSRGTAKVDLDKIVDHFTR
Mvan_0870|M.vanbaalenii_PYR-1 TLDWLDAHGHGDMVGNSIAVINGVRRGARKGAGKGTAKVDLNKVVDHFAR
MSMEG_0975|M.smegmatis_MC2_155 TLDWLDAHGHQDLVRNSVAVLNAVRPRA--------GKVDLSKVVDHFSR
TH_0884|M.thermoresistible__bu TLDWLDAHGHQDMVRNSIAVINAVRPRS--------GKVDLQKVVDHFSR
MAB_3972c|M.abscessus_ATCC_199 TLDWLDAHGHRELVRRSIAVINAVRPRS--------GKVDMQKVVDHFSR
MLBr_00048|M.leprae_Br4923 ALDWLRHNGYQDLLSRACVVINHVMPKE--------PNIASKDLVQQFEQ
MUL_3237|M.ulcerans_Agy99 LTDTVEKVRDRLNPRLDITGILLTRYDPRTVN----SREVMARVVERFGD
* : . : . . ::::*
Mb0543|M.bovis_AF2122/97 RCR---AVRVVPFDPHLEEGAEIALDRLRRETREALTELAAVVAAGFP--
Rv0530|M.tuberculosis_H37Rv RCR---AVRVVPFDPHLEEGAEIALDRLRRETREALTELAAVVAAGFP--
MMAR_0876|M.marinum_M RCR---AVRLVPFDPHLEEGAEIVLDRMKRETREALAELAAVVAEGFG--
MAV_4615|M.avium_104 RCR---AVQLVPFDPHLEEGAEIDLDRLRRGTREALTELAAIVADGFP--
Mflv_0048|M.gilvum_PYR-GCK RCR---AVCQVPFDAHLEEGAEISLDRLRPQTRESLLELAAAVADGFP--
Mvan_0870|M.vanbaalenii_PYR-1 RCR---AVCQVPFDPHLEEGAEISLDRLRADTRESLLELAAAVADGFP--
MSMEG_0975|M.smegmatis_MC2_155 RCR---AVRLVPFDPHLEEGAEISLDRLKPKTREALLELAAVVAGDFGSD
TH_0884|M.thermoresistible__bu RCR---AVKMVPFDPHLEEGAEIDLDQLKPQTRQALLELAAVVADGFP--
MAB_3972c|M.abscessus_ATCC_199 RCR---AVRLVPFDPHLEEGAEISLDRLRPQTRRALIELAAVVAQGFT--
MLBr_00048|M.leprae_Br4923 QIQP-GRVVVLPWDKHIAAGTEIRLDRLDPLYRRRILELAAALSDDFER-
MUL_3237|M.ulcerans_Agy99 LVFDTVITRTVRFPETSVAGEPITTWAPKSAGALAYRALAREFIDRFGV-
. : : * * ** . *
Mb0543|M.bovis_AF2122/97 -----------GDPRRCKPSFT
Rv0530|M.tuberculosis_H37Rv -----------GDPRRCKPSFT
MMAR_0876|M.marinum_M -----------PDQRRSSPSFG
MAV_4615|M.avium_104 -----------G-AQRNPGVLG
Mflv_0048|M.gilvum_PYR-GCK -----------GARNRSDPAD-
Mvan_0870|M.vanbaalenii_PYR-1 -----------GAR-RTDPVG-
MSMEG_0975|M.smegmatis_MC2_155 RTGALGGADSAGSRRIADPRV-
TH_0884|M.thermoresistible__bu -----------GAQQLQSPPF-
MAB_3972c|M.abscessus_ATCC_199 -----------GTQRQQQTFQG
MLBr_00048|M.leprae_Br4923 -------------AGRH-----
MUL_3237|M.ulcerans_Agy99 ----------------------