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MTSLSIHQENAELQLNDQIYGDDPLSDRETGLYRAEYVMSFVEKWDELIDWDARSESEGRFFVDVLRARD KQNILDVATGTGFHSVRLTEAGFNVTSADGSAAMLAKAFENGRKRGLILRTVQADWRELNRDIQGKYDAI ICLGNSFTHLHDEHDRRRALAEFYAALRHDGILILDQRNYDEILDHGFKSKHKYYYCGDQVTAEPEYVDE GLARFKYDFPDGSEYTLNMFPLRKSYVRRLMREAGFTTVRTYGDFQESYEETEPDFFIHVAEKSLASEAL AEPDIDAALTGTRAEPEAYYDSDDANAFYSMIWGGEDIHVGCYEDTRDIGAAARKTVDRMVRQLTRFDGD TRVLDLGAGYGGCARHLASDYGSSVTCLNISEAQNETNRERNRNAGLDVKIRVVHGSFEAIPEPDGSYDV VWSQDAILHAADRRKVIEEAFRVLKAGGELIFTDPMQADEVPDGVLAPVYDRLNLADLGSMRFYRETALA VGFEVVDQIDLVHNLGVHYQRVLEELETRRRELEEHSSTEYLDKMRVGLRNWVDSAREGHLAWGIQHFRK PD
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_0861 | - | - | 100% (562) | glycine-sarcosine methyltransferase |
| M. marinum M | MMAR_0694 | - | 2e-16 | 29.26% (229) | hypothetical protein MMAR_0694 |
| M. marinum M | MMAR_3170 | - | 9e-08 | 31.86% (113) | methyltransferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0533 | - | 2e-50 | 81.42% (113) | hypothetical protein Mb0533 |
| M. gilvum PYR-GCK | Mflv_2862 | - | 1e-07 | 31.68% (161) | methyltransferase type 11 |
| M. tuberculosis H37Rv | Rv0520 | - | 2e-50 | 81.42% (113) | hypothetical protein Rv0520 |
| M. leprae Br4923 | MLBr_01723 | - | 1e-06 | 23.58% (212) | hypothetical protein MLBr_01723 |
| M. abscessus ATCC 19977 | MAB_0018c | - | 1e-08 | 27.37% (190) | putative methyltransferase |
| M. avium 104 | MAV_3570 | - | 3e-06 | 33.80% (71) | thiopurine S-methyltransferase (tpmt) superfamily protein |
| M. smegmatis MC2 155 | MSMEG_2350 | - | 3e-10 | 34.12% (170) | hypothetical protein MSMEG_2350 |
| M. thermoresistible (build 8) | TH_0087 | - | 2e-07 | 26.90% (145) | methyltransferase type 11 |
| M. ulcerans Agy99 | MUL_2377 | - | 8e-08 | 31.86% (113) | methyltransferase |
| M. vanbaalenii PYR-1 | Mvan_1888 | - | 2e-07 | 31.37% (102) | methyltransferase type 11 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0533|M.bovis_AF2122/97 --------------------------------------------------
Rv0520|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0861|M.marinum_M MTSLSIHQENAELQLNDQIYGDDPLSDRETGLYRAEYVMSFVEKWDELID
MAV_3570|M.avium_104 --------------------------------------------------
Mvan_1888|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_0087|M.thermoresistible__bu --------------------------------------------------
Mflv_2862|M.gilvum_PYR-GCK --------------------------------------------------
MAB_0018c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_2350|M.smegmatis_MC2_155 --------------------------------------------------
MUL_2377|M.ulcerans_Agy99 --------------------------------------------------
MLBr_01723|M.leprae_Br4923 --------------------------------------------------
Mb0533|M.bovis_AF2122/97 --------------------------------------------------
Rv0520|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0861|M.marinum_M WDARSESEGRFFVDVLRARDKQNILDVATGTGFHSVRLTEAGFNVTSADG
MAV_3570|M.avium_104 --------------------------------------------------
Mvan_1888|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_0087|M.thermoresistible__bu --------------------------------------------------
Mflv_2862|M.gilvum_PYR-GCK --------------------------------------------------
MAB_0018c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_2350|M.smegmatis_MC2_155 --------------------------------------------------
MUL_2377|M.ulcerans_Agy99 --------------------------------------------------
MLBr_01723|M.leprae_Br4923 --------------------------------------------------
Mb0533|M.bovis_AF2122/97 --------------------------------------------------
Rv0520|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0861|M.marinum_M SAAMLAKAFENGRKRGLILRTVQADWRELNRDIQGKYDAIICLGNSFTHL
MAV_3570|M.avium_104 --------------------------------------------------
Mvan_1888|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_0087|M.thermoresistible__bu --------------------------------------------------
Mflv_2862|M.gilvum_PYR-GCK --------------------------------------------------
MAB_0018c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_2350|M.smegmatis_MC2_155 --------------------------------------------------
MUL_2377|M.ulcerans_Agy99 --------------------------------------------------
MLBr_01723|M.leprae_Br4923 --------------------------------------------------
Mb0533|M.bovis_AF2122/97 --------------------------------------------------
Rv0520|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0861|M.marinum_M HDEHDRRRALAEFYAALRHDGILILDQRNYDEILDHGFKSKHKYYYCGDQ
MAV_3570|M.avium_104 --------------------------------------------------
Mvan_1888|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_0087|M.thermoresistible__bu --------------------------------------------------
Mflv_2862|M.gilvum_PYR-GCK --------------------------------------------------
MAB_0018c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_2350|M.smegmatis_MC2_155 --------------------------------------------------
MUL_2377|M.ulcerans_Agy99 --------------------------------------------------
MLBr_01723|M.leprae_Br4923 --------------------------------------------------
Mb0533|M.bovis_AF2122/97 --------------------------------------------------
Rv0520|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0861|M.marinum_M VTAEPEYVDEGLARFKYDFPDGSEYTLNMFPLRKSYVRRLMREAGFTTVR
MAV_3570|M.avium_104 --------------------------------------------------
Mvan_1888|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_0087|M.thermoresistible__bu --------------------------------------------------
Mflv_2862|M.gilvum_PYR-GCK --------------------------------------------------
MAB_0018c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_2350|M.smegmatis_MC2_155 --------------------------------------------------
MUL_2377|M.ulcerans_Agy99 --------------------------------------------------
MLBr_01723|M.leprae_Br4923 --------------------------------------------------
Mb0533|M.bovis_AF2122/97 --------------------------------------------------
Rv0520|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0861|M.marinum_M TYGDFQESYEETEPDFFIHVAEKSLASEALAEPDIDAALTGTRAEPEAYY
MAV_3570|M.avium_104 ---------------------------------------------MTASF
Mvan_1888|M.vanbaalenii_PYR-1 -----------------------------------------------MDL
TH_0087|M.thermoresistible__bu --------------------------------------------------
Mflv_2862|M.gilvum_PYR-GCK -------------------------------------------------M
MAB_0018c|M.abscessus_ATCC_199 -----MTTLTSDFTDESTGERLRRWADEWRRMAAVAVSSADGPKTGMVYD
MSMEG_2350|M.smegmatis_MC2_155 -------------------------------------------------M
MUL_2377|M.ulcerans_Agy99 ----------------MAFSPAHRLLARLGSTSIYKRVWRYWYPLMTRGL
MLBr_01723|M.leprae_Br4923 ----------------------MTRSTEISANAVPNPHATAEQVAAARKD
Mb0533|M.bovis_AF2122/97 --------------------------------------------------
Rv0520|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0861|M.marinum_M DSDDANAFYSMIWGGEDIHVGCYEDTRDIGAAARKTVDRMVRQLTRFDGD
MAV_3570|M.avium_104 DPADPARFEEMYRDQRTSHGLPAATPWDIGGPQPVVRQLVALGAVKG---
Mvan_1888|M.vanbaalenii_PYR-1 TPR-LSRFDEFYKNQTP--------PWVIGEPQQAIVELEQAGLIGG---
TH_0087|M.thermoresistible__bu ---------------------------------MLTVDYDRLGIGPG---
Mflv_2862|M.gilvum_PYR-GCK NMAETALINSAPR------------RWLQRVYEVPVLLRFGGRLVPD---
MAB_0018c|M.abscessus_ATCC_199 IVGPQNLFGEESLFINFGYWRDHPTTLDEASRDLARLVASSAGFTAS---
MSMEG_2350|M.smegmatis_MC2_155 GDPDNALPSALPLTGERTIPGLAEENYWFRRHEVVYQRLAHRCAGRD---
MUL_2377|M.ulcerans_Agy99 GADKIAFLNWAYEEDPPIDLTLEVSDEPNRDHINMYHRTATHVELSG---
MLBr_01723|M.leprae_Br4923 SKLAQVLYHDWEAENYDEKWSISYDQRCVDYVRHCFDAIVPDELFTELPY
Mb0533|M.bovis_AF2122/97 ---------MG-GCS----------ITCLNISEVPNETNR------KKNR
Rv0520|M.tuberculosis_H37Rv ---------MG-GCS----------ITCLNISEVPNETNR------KKNR
MMAR_0861|M.marinum_M TRVLDLGAGYG-GCARHLASDYGSSVTCLNISEAQNETNR------ERNR
MAV_3570|M.avium_104 -EVLDPGTGPG-HHAIYYASQG-FSATGIDGSAAAIERAR------ANAR
Mvan_1888|M.vanbaalenii_PYR-1 -RVLDVGCGTG-EHTILLARAG-YDVLGIDGAPTAVEQAR------RNAE
TH_0087|M.thermoresistible__bu VSVIDVGCGLG-RHSFEAYRRG-AHIVAFDQNAEELNEVDTILQAMAEQR
Mflv_2862|M.gilvum_PYR-GCK TQALEIGCGSGYGTQLILERFGAATVDAVDLDPAMIRRAG--------ER
MAB_0018c|M.abscessus_ATCC_199 DVVVDCGCGYGDQDILWANEFKVKKITGVNIAEEQIAIST------ERVA
MSMEG_2350|M.smegmatis_MC2_155 --VLEAGCGEGYGADLIADVAR--RVIGLDYDEATVAHVR----------
MUL_2377|M.ulcerans_Agy99 KRVLEVSCGHGGGASYLTRTLHPASYTGLDLNRAGIKLCQR---------
MLBr_01723|M.leprae_Br4923 DCALELGCGTGFFLLNLIQSGVARRGSVTDLSPGMVKIATR--------N
* :
Mb0533|M.bovis_AF2122/97 QAGLDRSIRVIHGSFDDI----PEPDSGYDVVWSQDAILHAPD--RRKVL
Rv0520|M.tuberculosis_H37Rv QAGLDRSIRVIHGSFDDI----PEPDSGYDVVWSQDAILHAPD--RRKVL
MMAR_0861|M.marinum_M NAGLDVKIRVVHGSFEAI----PEPDGSYDVVWSQDAILHAAD--RRKVI
MAV_3570|M.avium_104 TAGVSVNFELADATKLDG----FDGRFDTVVDCAFYHVFATEPELRSSYA
Mvan_1888|M.vanbaalenii_PYR-1 AQGVDARFELADALHLG-----PDPTYDTIVDSALFHIFDDAD--RATYV
TH_0087|M.thermoresistible__bu EAPAGARAEVVKGDALDL----PYADGTFDRVIASEILEHVPE--DDRAI
Mflv_2862|M.gilvum_PYR-GCK LARYGNRVRLVQGSATDLSTALDAGDGSYGAVFDFGIVHHIPD--WRNAV
MAB_0018c|M.abscessus_ATCC_199 EAGLSDTISYVKASATDL----PFENESCTKVVALESAFHFPS--RIDFF
MSMEG_2350|M.smegmatis_MC2_155 --ARYPRVDIRHGNLAEL----PLPDASVDVVVNFQVIEHLWD--QAQFV
MUL_2377|M.ulcerans_Agy99 -RHNLPGLDFVRGDAENL----PFEDESFDVVLKVEASHCYPH--FSRFL
MLBr_01723|M.leprae_Br4923 GQSLGLDINGRVADAEGI----PYDDNTFDLVVGHAVLHHIPD--VELSL
.
Mb0533|M.bovis_AF2122/97 EEAFRVLRPGG------------ELIFTDPMQADDVPDGVLQPVYDRL--
Rv0520|M.tuberculosis_H37Rv EEAFRVLRPGG------------ELIFTDPMQADDVPDGVLQPVYDRL--
MMAR_0861|M.marinum_M EEAFRVLKAGG------------ELIFTDPMQADEVPDGVLAPVYDRL--
MAV_3570|M.avium_104 RALHRATKPGA------------RLYMFEFGEHDVNGFKMMRSLSEND--
Mvan_1888|M.vanbaalenii_PYR-1 RSLHAATRPGS------------VVHLLALSD---SGRGFGPEVSEHT--
TH_0087|M.thermoresistible__bu AELVRVLKPGGKLVVTVPRWLPERICWLLSDEYHANEGGHVRIYRADE--
Mflv_2862|M.gilvum_PYR-GCK AEVARVLAPGG-------------RFYFDEVTAHALARPSYKRLFDHP--
MAB_0018c|M.abscessus_ATCC_199 REALRVLKPGG------------RMVTADIVPRRTALTAFARSQVARRG-
MSMEG_2350|M.smegmatis_MC2_155 SECFRVLRPGG----------VFLVSTPNRITFSPGRDTPLNPFHTRELN
MUL_2377|M.ulcerans_Agy99 AEVVRVLRPGG-------------YLLYTDLRPSNEIAEWEADLAGSP--
MLBr_01723|M.leprae_Br4923 REVLRVLKPGG-----------RFVFAGEPTDVGNRYARVFADLTWKVTI
. .*.
Mb0533|M.bovis_AF2122/97 -------------------NLRDLGSMRFYA-------------------
Rv0520|M.tuberculosis_H37Rv -------------------NLRDLGSMRFYA-------------------
MMAR_0861|M.marinum_M -------------------NLADLGSMRFYRETALAVGFEVVDQIDLVHN
MAV_3570|M.avium_104 -------------------FRDVLPAAGWEISYLGPTTYQVNLSAETIQM
Mvan_1888|M.vanbaalenii_PYR-1 -------------------IRAAF-GAGWEVEALTETTYRG---------
TH_0087|M.thermoresistible__bu -------------------LRDKITRHGLRLTHRHHAHALHSPFWWLKCA
Mflv_2862|M.gilvum_PYR-GCK -------------------TEDRFSAEQFSDELAHHG-------------
MAB_0018c|M.abscessus_ATCC_199 ------------------WQGAPANAVPWAVDVQGYRDLLLDMGFARSET
MSMEG_2350|M.smegmatis_MC2_155 ----------------AAELTELLETAGFEVEDTLGVFHGAGLAELDARH
MUL_2377|M.ulcerans_Agy99 --------------------LRQLSQREINAEVVRGIEKNSHTSRVLVDR
MLBr_01723|M.leprae_Br4923 RVVQLPGLSAWRRTQVEIDENSRAAALEWVVDLHTFEPKVLETMATNAGA
Mb0533|M.bovis_AF2122/97 --------------------------------------------------
Rv0520|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0861|M.marinum_M LGVHYQRVLEELETRRRELEEHSSTEYLDKMRVGLRNWVDSAREGHLAWG
MAV_3570|M.avium_104 M------------AARNPDMADEAAKLLERFRAMEPWLQAG-RVHAPFWE
Mvan_1888|M.vanbaalenii_PYR-1 ------------------VVIDAHTEALN--------LPAGTVVDEPAWS
TH_0087|M.thermoresistible__bu VGTNNDRHFAVRAYHQLLVWDMVRRPWVTRWAEEMLNPLIGKSVALYFDK
Mflv_2862|M.gilvum_PYR-GCK ------------------LVVLGSRTRIQG------DYLLGVAAKPLPTG
MAB_0018c|M.abscessus_ATCC_199 WSIANDVYPPLSKFLGKRLRQPDMKHVNPLLRAQFNSVGMRLFSLHSDYI
MSMEG_2350|M.smegmatis_MC2_155 GGSIIEAQVQRAVADAPWDEQLLADVAAVRTDDFDLTPAAERDIDDSLDL
MUL_2377|M.ulcerans_Agy99 N--------------LPAFLRFADRAVGRQLSRYLEGGELSYRMYCFTKD
MLBr_01723|M.leprae_Br4923 VQVKTVTEEFTAAMLGWPLRTFESTMPPSKLGWGWARFAFTSWKTLSWVD
Mb0533|M.bovis_AF2122/97 ------------------------
Rv0520|M.tuberculosis_H37Rv ------------------------
MMAR_0861|M.marinum_M IQHFRKPD----------------
MAV_3570|M.avium_104 VHATRVD-----------------
Mvan_1888|M.vanbaalenii_PYR-1 ARIRRL------------------
TH_0087|M.thermoresistible__bu PEVAGADS----------------
Mflv_2862|M.gilvum_PYR-GCK CE----------------------
MAB_0018c|M.abscessus_ATCC_199 VAVAHKA-----------------
MSMEG_2350|M.smegmatis_MC2_155 VAIAVRP-----------------
MUL_2377|M.ulcerans_Agy99 FAASR-------------------
MLBr_01723|M.leprae_Br4923 ANVWRRVIPKSWFYNIIITGVKPS