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LNALSPDAQQESGAACAIPSSGGAQPQSSTESGGPASHDYTDAMTRDFYDHEDSTYRGFWDPDGSLHWGV FEDDDTGFIAGCQHWNEQMLRAARIGPQSRVLDLGCGNGTVSAWLARQTGAQVTGIDLSAVRIANAQRLA ADNPQLQLEFMASSASALPFADGTFTHVFSQAVLYHVHDRERALAEVARVLQPQGLFVFDDLVTPQRPVS ALAREVVYDRLLFEPTFSADDYRKALARHGFVVYETRDLSPHLAQSYKLLADLAEPSCPRLATAYRQIPE VIQDAEVGWSFFLGKKVVDRLEWIYNSDPDLSLEQKYDAWAESYDSDLRDNYQENPRRAAALLAAHLPER SAPVLDAGAGTGLVGEELHKLGYDNLTALDRSLGMLSHARAKNVYRDVVHGALAAAPTLFPDQRFAAIVA VGVFTFAHAGPEDLAALDRVLEPGGWLVIAVRADYLDQHRTLEQTLAKLGYRIEARDEYEIFDAEPMVAL GCRKPINDDGASR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_0694 | - | - | 100% (504) | hypothetical protein MMAR_0694 |
| M. marinum M | MMAR_0861 | - | 2e-16 | 29.26% (229) | glycine-sarcosine methyltransferase |
| M. marinum M | MMAR_1663 | - | 5e-11 | 38.18% (110) | hypothetical protein MMAR_1663 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1440c | - | 4e-11 | 38.32% (107) | putative methyltransferase |
| M. gilvum PYR-GCK | Mflv_2862 | - | 3e-16 | 36.02% (161) | methyltransferase type 11 |
| M. tuberculosis H37Rv | Rv1405c | - | 4e-11 | 38.32% (107) | putative methyltransferase |
| M. leprae Br4923 | MLBr_02273 | ubiE | 6e-12 | 28.50% (193) | ubiquinone/menaquinone biosynthesis methyltransferase |
| M. abscessus ATCC 19977 | MAB_4018 | - | 1e-11 | 38.89% (108) | similarity with UbiE/COQ5 methyltransferase |
| M. avium 104 | MAV_3903 | - | 6e-11 | 37.27% (110) | methyltransferase, UbiE/COQ5 family protein |
| M. smegmatis MC2 155 | MSMEG_0098 | - | 9e-12 | 36.29% (124) | methyltransferase |
| M. thermoresistible (build 8) | TH_0087 | - | 5e-12 | 31.82% (154) | methyltransferase type 11 |
| M. ulcerans Agy99 | MUL_1900 | - | 3e-11 | 38.18% (110) | hypothetical protein MUL_1900 |
| M. vanbaalenii PYR-1 | Mvan_3244 | - | 3e-14 | 35.44% (158) | methyltransferase type 11 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1440c|M.bovis_AF2122/97 ----------------MTIDTPAREDQTLAAT-HRAMWALGDYALMAEEV
Rv1405c|M.tuberculosis_H37Rv ----------------MTIDTPAREDQTLAAT-HRAMWALGDYALMAEEV
Mflv_2862|M.gilvum_PYR-GCK -----------------------------MNM-AETALINSAPRRWLQRV
Mvan_3244|M.vanbaalenii_PYR-1 -----------------------------MNR-AETALINSPPRRWLQRL
MAV_3903|M.avium_104 ------MTRST----DAVPTPHATAEQVEAAR-HDSKLAQVLYHDWEAET
MUL_1900|M.ulcerans_Agy99 ------MTRSSEIPADAAPNPHATAEEVEAAR-HDSKLAQVLYHDWEAEN
MMAR_0694|M.marinum_M -MLNALSPDAQQESGAACAIPSSGGAQPQSST-ESGGPASHDYTDAMTRD
MSMEG_0098|M.smegmatis_MC2_155 --MDTALRRAMDLLIDPPAEPDFSKGYLDLLG-RGDSTAPKNTGLIQKAW
MAB_4018|M.abscessus_ATCC_1997 MLHHPTLADSLIDPARIDHPPRRDHGYLDVLGPESDEPVSVANRFMQSPL
MLBr_02273|M.leprae_Br4923 ---------MPPGSVDVVSRAALDKDPRDVVAMFDDVAHRYDLTNTVLSL
TH_0087|M.thermoresistible__bu --------------------------------------------------
Mb1440c|M.bovis_AF2122/97 MAPLGPILVAAAGIG----------------------------------P
Rv1405c|M.tuberculosis_H37Rv MAPLGPILVAAAGIG----------------------------------P
Mflv_2862|M.gilvum_PYR-GCK YEVPVLLRFGGRLV-----------------------------------P
Mvan_3244|M.vanbaalenii_PYR-1 YEVPVLLRFGGRLP-----------------------------------P
MAV_3903|M.avium_104 YDEKWSISYDQRCIDYARGRFDAIVPEHV----------------LRELP
MUL_1900|M.ulcerans_Agy99 YDEKWSISYDQRCVEYARGRFDAIVPAQV----------------HADLP
MMAR_0694|M.marinum_M FYDHEDSTYRGFWDPDGSLHWGVFEDDDTGFIAGCQHWNEQMLRAARIGP
MSMEG_0098|M.smegmatis_MC2_155 ASPLGSKLYDRAQLLNRRLVASTRPPVEWLR----------------IPP
MAB_4018|M.abscessus_ATCC_1997 LAAIYERAWRPMFTRGFSYGGKSTLKAHTALMDEIAG-----------RG
MLBr_02273|M.leprae_Br4923 GQDRYWRRATRSALR--------------------------------IGP
TH_0087|M.thermoresistible__bu ---MLTVDYDRLGIG----------------------------------P
Mb1440c|M.bovis_AF2122/97 GVRVLDVAAGSGNISLPAAKTG--ATVIS------TDLTPELLQRSQAR-
Rv1405c|M.tuberculosis_H37Rv GVRVLDVAAGSGNISLPAAKTG--ATVIS------TDLTPELLQRSQAR-
Mflv_2862|M.gilvum_PYR-GCK DTQALEIGCGSGYGTQLILERFGAATVDA------VDLDPAMIRRAGERL
Mvan_3244|M.vanbaalenii_PYR-1 GSGALEIGCGSGYGSQLVLQRFGAARIDA------VDLDPAMIERARTRL
MAV_3903|M.avium_104 YDRALELGCGTGFFLLNLIQSGVARRGSV------TDLSPGMVKVATR--
MUL_1900|M.ulcerans_Agy99 YERALELGCGTGFFLLNLIQAGVARRGSV------TDLSPGMVKVATR--
MMAR_0694|M.marinum_M QSRVLDLGCGNGTVSAWLARQTG-AQVTG------IDLSAVRIANAQR--
MSMEG_0098|M.smegmatis_MC2_155 GGTVLDIGCGPGNITAQLARAAGLDGLALG-----VDISEPMLARAVA--
MAB_4018|M.abscessus_ATCC_1997 DHKILDVACGPGLYTRELAAQLGTAGVCIG-----LDLSGPMLRRAVR--
MLBr_02273|M.leprae_Br4923 GQKVLDLAAGTAVSTAELSKSG---AWCVA-----ADFSVRMLATGGAR-
TH_0087|M.thermoresistible__bu GVSVIDVGCGLGRHSFEAYRRGAHIVAFDQNAEELNEVDTILQAMAEQR-
:::..* . :. .
Mb1440c|M.bovis_AF2122/97 ---AAQQGLTLQYQEANAQALPFADDEFDTVISAIGVMFAPDHQAAADEL
Rv1405c|M.tuberculosis_H37Rv ---AAQQGLTLQYQEANAQALPFADDEFDTVISAIGVMFAPDHQAAADEL
Mflv_2862|M.gilvum_PYR-GCK ARYGNRVRLVQGSATDLSTALDAGDGSYGAVFDFGIVHHIPDWRNAVAEV
Mvan_3244|M.vanbaalenii_PYR-1 APYGDRVHLATGSATDLREALNADDGSYDAVFDFGIIHHIPDWRAAVAEA
MAV_3903|M.avium_104 --NGQSLGLDIDGRVADAEGIPYEDDTFDLVVGHAVLHHIPDVELSLREV
MUL_1900|M.ulcerans_Agy99 --NGQSLGLDIDGRVADAEGIPYDDDTFDLVVGHAVLHHIPDVELSLREV
MMAR_0694|M.marinum_M -LAADNPQLQLEFMASSASALPFADGTFTHVFSQAVLYHVHDRERALAEV
MSMEG_0098|M.smegmatis_MC2_155 ----AEAGRQVGFVRADAQQLPFRDEVFDAATSLAVFQLIPDPVAAVSEI
MAB_4018|M.abscessus_ATCC_1997 ----DNSAERVDYIRGSAHSLPFADATFDTVVCLAALYLIPDPEQAVREL
MLBr_02273|M.leprae_Br4923 ---------KVPKVAADATQLPFSDGVFDAVTISFGLRNIADYQAALREM
TH_0087|M.thermoresistible__bu ---EAPAGARAEVVKGDALDLPYADGTFDRVIASEILEHVPEDDRAIAEL
: * : . . : : *
Mb1440c|M.bovis_AF2122/97 VRVCRPGGTIGVIS----------WTCEGFFGRMLATIRPYRPSVSADLP
Rv1405c|M.tuberculosis_H37Rv VRVCRPGGTIGVIS----------WTCEGFFGRMLATIRPYRPSVSADLP
Mflv_2862|M.gilvum_PYR-GCK ARVLAPGGRFYFD---------------EVTAHALARPSYKRL-------
Mvan_3244|M.vanbaalenii_PYR-1 ARVLIPGGRFYFE---------------EVTAHALSRPTYRLL-------
MAV_3903|M.avium_104 IRVLRPGGRFVFAGEP--------TSAGDVYARELSTLTWRIATNVTKLP
MUL_1900|M.ulcerans_Agy99 MRVLKPGGRFVFAGEP--------TTVGNEYARTLSTLTWRIATNVTKLP
MMAR_0694|M.marinum_M ARVLQPQGLFVFDDLVTPQRPVSALAREVVYDRLLFEPTFSADDYRKALA
MSMEG_0098|M.smegmatis_MC2_155 VRVLKPGGRVAIMVP---------------TAGAVKPVTFLARGGAR---
MAB_4018|M.abscessus_ATCC_1997 CRVAGPDGQIVVFTSLR------------TRAASLPGVTTAMRIGGFR--
MLBr_02273|M.leprae_Br4923 ARVTRPGGQLVVCEFS-------------TPTNALVANVYTEYLMRALPQ
TH_0087|M.thermoresistible__bu VRVLKPGGKLVVTVPR----------WLPERICWLLSDEYHANEGGHVR-
** * * . . :
Mb1440c|M.bovis_AF2122/97 PSALWGREAYVTG-------------------------------------
Rv1405c|M.tuberculosis_H37Rv PSALWGREAYVTG-------------------------------------
Mflv_2862|M.gilvum_PYR-GCK ----FDHPTEDR--------------------------------------
Mvan_3244|M.vanbaalenii_PYR-1 ----FDHPTDDR--------------------------------------
MAV_3903|M.avium_104 GLGSWRRPQAELDESSRA-------------------------AALEAIV
MUL_1900|M.ulcerans_Agy99 GLGGWRRPQEELDESSRA-------------------------AALEAIV
MMAR_0694|M.marinum_M RHGFVVYETRDLSPHLAQSYKLLADLAEPSCPRLATAYRQIPEVIQDAEV
MSMEG_0098|M.smegmatis_MC2_155 --------------------------------------------------
MAB_4018|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_02273|M.leprae_Br4923 VARLVSSNPDAY--------------------------------------
TH_0087|M.thermoresistible__bu --------------------------------------------------
Mb1440c|M.bovis_AF2122/97 ----LLGDGVTG-------------------------LKTARGLLEVKRF
Rv1405c|M.tuberculosis_H37Rv ----LLGDGVTG-------------------------LKTARGLLEVKRF
Mflv_2862|M.gilvum_PYR-GCK ----FSAEQFSD-------------------------ELAHHGLVVLG--
Mvan_3244|M.vanbaalenii_PYR-1 ----FTAEDFLD-------------------------ELGRHGLVILG--
MAV_3903|M.avium_104 DLHTFTPGDLER-------------------------MAANAGATEVR--
MUL_1900|M.ulcerans_Agy99 DLHTFAPEDLER-------------------------MAKNAGAIRVE--
MMAR_0694|M.marinum_M GWSFFLGKKVVDRLEWIYNSDPDLSLEQKYDAWAESYDSDLRDNYQENPR
MSMEG_0098|M.smegmatis_MC2_155 ---IFGDDELGD-------------------------IFENVGLVGVR--
MAB_4018|M.abscessus_ATCC_1997 ---AFGRDEVTG-------------------------WLRAQGWTDID--
MLBr_02273|M.leprae_Br4923 ---IYLAESIRAWP------------------------DQVTLACQLSRT
TH_0087|M.thermoresistible__bu ---IYRADELRD-------------------------KITRHGLRLTHRH
.
Mb1440c|M.bovis_AF2122/97 DTAQAVHDYFKNNYGPTIEAYAHIGDN----AVLAAELDRQLVELAAQYL
Rv1405c|M.tuberculosis_H37Rv DTAQAVHDYFKNNYGPTIEAYAHIGDN----AVLAAELDRQLVELAAQYL
Mflv_2862|M.gilvum_PYR-GCK SRTRIQGDYLLGVAAKPLPTGCE---------------------------
Mvan_3244|M.vanbaalenii_PYR-1 SVTRIQGDYLLGVAAKPLAADGGR--------------------------
MAV_3903|M.avium_104 TVSEEFTAAMFGWPVRTFEASVPPGRLGWGWAKFAFNGWKTLSWVDANIW
MUL_1900|M.ulcerans_Agy99 TASEEFSAAMFGWPVRTFESSVPPGRLGWNWARFAFNGWKALGWMDANVW
MMAR_0694|M.marinum_M RAAALLAAHLPERSAPVLDAGAGTGLVGEELHKLGYDNLTALDRSLGMLS
MSMEG_0098|M.smegmatis_MC2_155 ---VKTHGFIQWVRGTKL--------------------------------
MAB_4018|M.abscessus_ATCC_1997 QTVTGQGQFIRARRAVALRVAT----------------------------
MLBr_02273|M.leprae_Br4923 GWASPRWRNLTGGIVALHAADKPVR-------------------------
TH_0087|M.thermoresistible__bu HAHALHSPFWWLKCAVGTNNDRHFAVRAYHQLLVWDMVRRPWVTRWAEEM
Mb1440c|M.bovis_AF2122/97 SDG-VMEWEYLLLTAEKR--------------------------------
Rv1405c|M.tuberculosis_H37Rv SDG-VMEWEYLLLTAEKR--------------------------------
Mflv_2862|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3244|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_3903|M.avium_104 RRVVPKGWFYNVMVTGVKPT------------------------------
MUL_1900|M.ulcerans_Agy99 RHVAPKGWFYNVMVTGVKPS------------------------------
MMAR_0694|M.marinum_M HARAKNVYRDVVHGALAAAPTLFPDQRFAAIVAVGVFTFAHAGPEDLAAL
MSMEG_0098|M.smegmatis_MC2_155 --------------------------------------------------
MAB_4018|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_02273|M.leprae_Br4923 --------------------------------------------------
TH_0087|M.thermoresistible__bu LNPLIGKSVALYFDKPEVAGADS---------------------------
Mb1440c|M.bovis_AF2122/97 --------------------------------------------------
Rv1405c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_2862|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3244|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_3903|M.avium_104 --------------------------------------------------
MUL_1900|M.ulcerans_Agy99 --------------------------------------------------
MMAR_0694|M.marinum_M DRVLEPGGWLVIAVRADYLDQHRTLEQTLAKLGYRIEARDEYEIFDAEPM
MSMEG_0098|M.smegmatis_MC2_155 --------------------------------------------------
MAB_4018|M.abscessus_ATCC_1997 --------------------------------------------------
MLBr_02273|M.leprae_Br4923 --------------------------------------------------
TH_0087|M.thermoresistible__bu --------------------------------------------------
Mb1440c|M.bovis_AF2122/97 ----------------
Rv1405c|M.tuberculosis_H37Rv ----------------
Mflv_2862|M.gilvum_PYR-GCK ----------------
Mvan_3244|M.vanbaalenii_PYR-1 ----------------
MAV_3903|M.avium_104 ----------------
MUL_1900|M.ulcerans_Agy99 ----------------
MMAR_0694|M.marinum_M VALGCRKPINDDGASR
MSMEG_0098|M.smegmatis_MC2_155 ----------------
MAB_4018|M.abscessus_ATCC_1997 ----------------
MLBr_02273|M.leprae_Br4923 ----------------
TH_0087|M.thermoresistible__bu ----------------